MVB12B

The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Description

Multivesicular body subunit 12B

Tissue specificity

Tissue enhanced (brain)

Subcell location

Golgi apparatus, Vesicles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (126326829 - 126507041)

Ensembl ID

ENSG00000196814  (ver. 103.38)

Orthologs

Mouse Mvb12b: ENSMUSG00000038740

UniProt

Q9H7P6

neXtProt

NX_Q9H7P6

Human splice variants
Mouse splice variants

Protein structure