Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 11034-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11034-1-AP, RRID:AB_2096016
- Product name
- EIF2B2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated EIF2B2 antibody (Cat. #11034-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling.
A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation.
eIF2B conformation and assembly state regulate the integrated stress response.
Proteomic analysis of seminal extracellular vesicle proteins involved in asthenozoospermia by iTRAQ.
Cellular eIF2B subunit localization: implications for the integrated stress response and its control by small molecule drugs.
EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response.
The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes.
Stoichiometry of the eIF2B complex is maintained by mutual stabilization of subunits.
Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.
Zhang K, Huang M, Li A, Wen J, Yan L, Li Y, Guo L, Senthil KS, Zhou Y, Chen G, Liu Y, Zhang X, Yao X, Qin D, Su H
Cell reports 2023 Jan 31;42(1):111986
Cell reports 2023 Jan 31;42(1):111986
A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation.
Boone M, Wang L, Lawrence RE, Frost A, Walter P, Schoof M
eLife 2022 Apr 13;11
eLife 2022 Apr 13;11
eIF2B conformation and assembly state regulate the integrated stress response.
Schoof M, Boone M, Wang L, Lawrence R, Frost A, Walter P
eLife 2021 Mar 10;10
eLife 2021 Mar 10;10
Proteomic analysis of seminal extracellular vesicle proteins involved in asthenozoospermia by iTRAQ.
Lin Y, Liang A, He Y, Li Z, Li Z, Wang G, Sun F
Molecular reproduction and development 2019 Sep;86(9):1094-1105
Molecular reproduction and development 2019 Sep;86(9):1094-1105
Cellular eIF2B subunit localization: implications for the integrated stress response and its control by small molecule drugs.
Hodgson RE, Varanda BA, Ashe MP, Allen KE, Campbell SG
Molecular biology of the cell 2019 Apr 1;30(8):942-958
Molecular biology of the cell 2019 Apr 1;30(8):942-958
EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response.
Moon SL, Parker R
RNA (New York, N.Y.) 2018 Jun;24(6):841-852
RNA (New York, N.Y.) 2018 Jun;24(6):841-852
The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes.
Wong YL, LeBon L, Edalji R, Lim HB, Sun C, Sidrauski C
eLife 2018 Feb 28;7
eLife 2018 Feb 28;7
Stoichiometry of the eIF2B complex is maintained by mutual stabilization of subunits.
Wortham NC, Stewart JD, Harris S, Coldwell MJ, Proud CG
The Biochemical journal 2016 Mar 1;473(5):571-80
The Biochemical journal 2016 Mar 1;473(5):571-80
Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.
Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P
eLife 2015 Apr 15;4:e07314
eLife 2015 Apr 15;4:e07314
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 11034-1-AP(EIF2B2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The EIF2B2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human EIF2B2. This antibody recognizes human,mouse,rat antigen. The EIF2B2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.