BS5812

antibody from Bioworld Technology, Inc
Targeting: SCN4A HYKPP, HYPP, Nav1.4, SkM1
Provider product page for BS5812

Antibody data

Product number
BS5812 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Na+ CP type IVÏ« polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 472-517 of Human Na+ CP type IVÏ«.
Description
Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The three glycoproteins that comprise the voltagegated sodium channel proteins include a pore-forming Ï« subunit, a noncovalently associated ÉÇ1 subunit and a disulfide-linked ÉÇ2 subunit. The two ÉÇ subunits regulate the level of channel expression, modulate gating and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction. The Ï« subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type IIÏ« subunits are more abundant along axons. The ÉÇ1 subunit of sodium channel type I is expressed in brain, skeletal and cardiac muscle. In the brain, ÉÇ1 and ÉÇ2 are highly expressed in Purkinje cells, and ÉÇ1 is also expressed in the pyramidal cells of the deep cerebellar nuclei. Impaired voltage-gated sodium channels lead to a number of diseases including myotonia.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SCN4A protein structure - BS5812 shown in red.