12794-1-AP

antibody from Proteintech Group

Targeting: CETN1 CEN1, CETN

Provider product page for 12794-1-AP

Western blot

ELISA

Immunocytochemistry

Antibody data

Antibody Data
Antigen structure
References [25]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 12794-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12794-1-AP, RRID:AB_2077371
Product name: Centrin 1 antibody
Antibody type: Polyclonal
Description: Centrin 1 antibody (Cat. #12794-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CETN1 protein structure - 12794-1-AP shown in red.

Submitted references Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies.

Rosa E Silva I, Binó L, Johnson CM, Rutherford TJ, Neuhaus D, Andreeva A, Čajánek L, van Breugel M
Structure (London, England : 1993) 2022 Jan 6;30(1):114-128.e9

Loss of DRC1 function leads to multiple morphological abnormalities of the sperm flagella and male infertility in human and mouse.

Zhang J, He X, Wu H, Zhang X, Yang S, Liu C, Liu S, Hua R, Zhou S, Zhao S, Hu F, Zhang J, Liu W, Cheng H, Gao Y, Zhang F, Cao Y, Liu M
Human molecular genetics 2021 Oct 13;30(21):1996-2011

PLK4-phosphorylated NEDD1 facilitates cartwheel assembly and centriole biogenesis initiations.

Chi W, Wang G, Xin G, Jiang Q, Zhang C
The Journal of cell biology 2021 Jan 4;220(1)

O-GlcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis.

Yu F, Li T, Sui Y, Chen Q, Yang S, Yang J, Hong R, Li D, Yan X, Zhao W, Zhu X, Zhou J
Protein & cell 2020 Nov;11(11):852-857

ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia.

Ran J, Liu M, Feng J, Li H, Ma H, Song T, Cao Y, Zhou P, Wu Y, Yang Y, Yang Y, Yu F, Guo H, Zhang L, Xie S, Li D, Gao J, Zhang X, Zhu X, Zhou J
Developmental cell 2020 May 4;53(3):287-299.e5

Homozygous mutations in DZIP1 can induce asthenoteratospermia with severe MMAF.

Lv M, Liu W, Chi W, Ni X, Wang J, Cheng H, Li WY, Yang S, Wu H, Zhang J, Gao Y, Liu C, Li C, Yang C, Tan Q, Tang D, Zhang J, Song B, Chen YJ, Li Q, Zhong Y, Zhang Z, Saiyin H, Jin L, Xu Y, Zhou P, Wei Z, Zhang C, He X, Zhang F, Cao Y
Journal of medical genetics 2020 Jul;57(7):445-453

Secreted Wnt6 mediates diabetes-associated centrosome amplification via its receptor FZD4.

He QJ, Wang P, Liu QQ, Wu QG, Li YF, Wang J, Lee SC
American journal of physiology. Cell physiology 2020 Jan 1;318(1):C48-C62

Characterisation of centriole biogenesis during multiciliation in planarians.

Li Y, Guo F, Jing Q, Zhu X, Yan X
Biology of the cell 2020 Dec;112(12):398-408

Centrosomal Localization of RXRα Promotes PLK1 Activation and Mitotic Progression and Constitutes a Tumor Vulnerability.

Xie G, Zhou Y, Tu X, Ye X, Xu L, Xiao Z, Wang Q, Wang X, Du M, Chen Z, Chi X, Zhang X, Xia J, Zhang X, Zhou Y, Li Z, Xie C, Sheng L, Zeng Z, Zhou H, Yin Z, Su Y, Xu Y, Zhang XK
Developmental cell 2020 Dec 21;55(6):707-722.e9

Posterior Neocortex-Specific Regulation of Neuronal Migration by CEP85L Identifies Maternal Centriole-Dependent Activation of CDK5.

Kodani A, Kenny C, Lai A, Gonzalez DM, Stronge E, Sejourne GM, Isacco L, Partlow JN, O'Donnell A, McWalter K, Byrne AB, Barkovich AJ, Yang E, Hill RS, Gawlinski P, Wiszniewski W, Cohen JS, Fatemi SA, Baranano KW, Sahin M, Vossler DG, Yuskaitis CJ, Walsh CA
Neuron 2020 Apr 22;106(2):246-255.e6

Wdr47 Controls Neuronal Polarization through the Camsap Family Microtubule Minus-End-Binding Proteins.

Chen Y, Zheng J, Li X, Zhu L, Shao Z, Yan X, Zhu X
Cell reports 2020 Apr 21;31(3):107526

Bisphenol A disrupts mitotic progression via disturbing spindle attachment to kinetochore and centriole duplication in cancer cell lines.

Kim S, Gwon D, Kim JA, Choi H, Jang CY
Toxicology in vitro : an international journal published in association with BIBRA 2019 Sep;59:115-125

MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium.

Xie S, Farmer T, Naslavsky N, Caplan S
Journal of cell science 2019 Nov 14;132(22)

Resting cells rely on the DNA helicase component MCM2 to build cilia.

Casar Tena T, Maerz LD, Szafranski K, Groth M, Blätte TJ, Donow C, Matysik S, Walther P, Jeggo PA, Burkhalter MD, Philipp M
Nucleic acids research 2019 Jan 10;47(1):134-151

c-Cbl Acts as an E3 Ligase Against DDA3 for Spindle Dynamics and Centriole Duplication during Mitosis.

Gwon D, Hong J, Jang CY
Molecules and cells 2019 Dec 31;42(12):840-849

Parental centrioles are dispensable for deuterosome formation and function during basal body amplification.

Zhao H, Chen Q, Fang C, Huang Q, Zhou J, Yan X, Zhu X
EMBO reports 2019 Apr;20(4)

Vesicular trafficking plays a role in centriole disengagement and duplication.

Xie S, Reinecke JB, Farmer T, Bahl K, Yeow I, Nichols BJ, McLamarrah TA, Naslavsky N, Rogers GC, Caplan S
Molecular biology of the cell 2018 Nov 1;29(22):2622-2631

Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis.

Mori M, Hazan R, Danielian PS, Mahoney JE, Li H, Lu J, Miller ES, Zhu X, Lees JA, Cardoso WV
Nature communications 2017 Jul 4;8:15857

DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6.

Xu X, Huang S, Zhang B, Huang F, Chi W, Fu J, Wang G, Li S, Jiang Q, Zhang C
Nature communications 2017 Apr 27;8:15164

NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1.

Zhang C, Zhang W, Lu Y, Yan X, Yan X, Zhu X, Liu W, Yang Y, Zhou T
Cell research 2016 Feb;26(2):239-53

The tumor suppressor proteins ASPP1 and ASPP2 interact with C-Nap1 and regulate centrosome linker reassembly.

Zhang Y, Wang Y, Wei Y, Ma J, Peng J, Wumaier R, Shen S, Zhang P, Yu L
Biochemical and biophysical research communications 2015 Mar 13;458(3):494-500

Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication.

Kodani A, Yu TW, Johnson JR, Jayaraman D, Johnson TL, Al-Gazali L, Sztriha L, Partlow JN, Kim H, Krup AL, Dammermann A, Krogan NJ, Walsh CA, Reiter JF
eLife 2015 Aug 22;4

Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages.

Kodani A, Salomé Sirerol-Piquer M, Seol A, Garcia-Verdugo JM, Reiter JF
The EMBO journal 2013 Feb 20;32(4):597-607

The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis.

Zhao H, Zhu L, Zhu Y, Cao J, Li S, Huang Q, Xu T, Huang X, Yan X, Zhu X
Nature cell biology 2013 Dec;15(12):1434-44

Misfolded Gβ is recruited to cytoplasmic dynein by Nudel for efficient clearance.

Wan Y, Yang Z, Guo J, Zhang Q, Zeng L, Song W, Xiao Y, Zhu X
Cell research 2012 Jul;22(7):1140-54

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HL-60 cells were subjected to SDS PAGE followed by western blot with 12794-1-AP(CETN1 antibody) at dilution of 1:300
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of Hela cells, using CETN1 antibody 12794-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line