ADAMTS16

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may inhibit chondrosarcoma cell proliferation and migration. This gene may regulate blood pressure. [provided by RefSeq, May 2016]

Description

ADAM metallopeptidase with thrombospondin type 1 motif 16

Tissue specificity

Tissue enhanced (brain, ovary)

Subcell location

Nucleoplasm, Nuclear membrane, Midbody ring, Mitochondria

Predicted location

Secreted to extracellular matrix

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Kim et al 2014)

Chromosome

5 (5140330 - 5320304)

Ensembl ID

ENSG00000145536  (ver. 103.38)

Orthologs

Mouse Adamts16: ENSMUSG00000049538

UniProt

Q8TE57

neXtProt

NX_Q8TE57

Human splice variants
Mouse splice variants

Protein structure