21584-1-AP

antibody from Proteintech Group

Targeting: DLL4

Provider product page for 21584-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [17]
Comments [0]
Validations
Western blot [2]

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Product number: 21584-1-AP - Provider product page
Provider: Proteintech Group
Product name: DLL4 antibody
Antibody type: Polyclonal
Description: DLL4 antibody (Cat. #21584-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IP, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

DLL4 protein structure - 21584-1-AP shown in red.

Submitted references Vasorin Exocytosed from Glioma Cells Facilitates Angiogenesis via VEGFR2/AKT Signaling Pathway.

Zhong Y, Kang H, Ma Z, Li J, Qin Z, Zhang Z, Li P, Zhong Y, Wang L
Molecular cancer research : MCR 2024 Jul 2;22(7):668-681

LRP1 induces anti-PD-1 resistance by modulating the DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage polarisation in bladder cancer.

Lin H, Fu L, Zhou X, Yu A, Chen Y, Liao W, Shu G, Zhang L, Tan L, Liang H, Wang Z, Deng Q, Wang J, Jin M, Chen Z, Wei J, Cao J, Chen W, Li X, Li P, Lu J, Luo J
Cancer letters 2024 Jul 1;593:216807

Berberine promotes lacteal junction zippering and ameliorates diet-induced obesity through the RhoA/ROCK signaling pathway.

Wang H, Chen S, Tang Y, Nie K, Gao Y, Wang Z, Su H, Wu F, Gong J, Fang K, Dong H, Hu M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155268

APEX1 predicts poor prognosis of gallbladder cancer and affects biological properties of CD133(+) GBC-SD cells via upregulating Jagged1.

Wu Z, Liu Z, Sun Y, Yuan Y, Zou Q, Wen Y, Luo J, Liu R
Journal of Cancer 2023;14(8):1443-1457

Personalized drug screening in patient-derived organoids of biliary tract cancer and its clinical application.

Ren X, Huang M, Weng W, Xie Y, Wu Y, Zhu S, Zhang Y, Li D, Lai J, Shen S, Lin J, Kuang M, Li X, Yu J, Xu L
Cell reports. Medicine 2023 Nov 21;4(11):101277

Atractylenolide III Attenuates Angiogenesis in Gastric Precancerous Lesions Through the Downregulation of Delta-Like Ligand 4.

Gao Y, Wang J, Zhao M, Xia T, Liu Q, Chen N, Liao W, Zeng Z, You F, Zeng J
Frontiers in pharmacology 2022;13:797805

Endothelial PERK-ATF4-JAG1 axis activated by T-ALL remodels bone marrow vascular niche.

Liu C, Chen Q, Shang Y, Chen L, Myers J, Awadallah A, Sun J, Yu S, Umphred-Wilson K, Che D, Dou Y, Li L, Wearsch P, Ramírez-Bergeron D, Beck R, Xin W, Jin G, Adoro S, Zhou L
Theranostics 2022;12(6):2894-2907

Endothelial-Specific Molecule 1 Inhibition Lessens Productive Angiogenesis and Tumor Metastasis to Overcome Bevacizumab Resistance.

Kang N, Liang X, Fan B, Zhao C, Shen B, Ji X, Liu Y
Cancers 2022 Nov 18;14(22)

Dysregulation of the miR-30c/DLL4 axis by circHIPK3 is essential for KSHV lytic replication.

Harper KL, Mottram TJ, Anene CA, Foster B, Patterson MR, McDonnell E, Macdonald A, Westhead D, Whitehouse A
EMBO reports 2022 May 4;23(5):e54117

Electrochemically derived nanographene oxide activates endothelial tip cells and promotes angiogenesis by binding endogenous lysophosphatidic acid.

Liu W, Luo H, Wei Q, Liu J, Wu J, Zhang Y, Chen L, Ren W, Shao L
Bioactive materials 2022 Mar;9:92-104

Hibiscus syriacus L. cultivated in callus culture exerts cytotoxicity in colorectal cancer via Notch signaling-mediated cholesterol biosynthesis suppression.

Xu XY, Choi HS, Park SY, Kim JK, Seo KH, Kim H, Kim YJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153870

Anti-DLL4 ameliorates toluene diisocyanate-induced experimental asthma by inhibiting Th17 response.

Deng Y, Chen S, Song S, Huang Y, Chen R, Tao A
International immunopharmacology 2021 May;94:107444

Role of the Notch ligands Jagged1 and Delta4 in Th17/Treg immune imbalance in a mouse model of chronic asthma.

He Z, Wu J, Zeng X, Bao H, Liu X
Experimental lung research 2021 May-Aug;47(6):289-299

Angiogenic responses in a 3D micro-engineered environment of primary endothelial cells and pericytes.

Bai J, Khajavi M, Sui L, Fu H, Tarakkad Krishnaji S, Birsner AE, Bazinet L, Kamm RD, D'Amato RJ
Angiogenesis 2021 Feb;24(1):111-127

Knockdown of growth factor receptor bound protein 7 suppresses angiogenesis by inhibiting the secretion of vascular endothelial growth factor A in ovarian cancer cells.

Xu Q, Liu Z, Zhu ZQ, Fan Y, Chen R, Xie XH, Cheng M
Bioengineered 2021 Dec;12(2):12179-12190

Long non-coding RNA GAPLINC promotes angiogenesis by regulating miR-211 under hypoxia in human umbilical vein endothelial cells.

He Y, Wu Z, Qiu C, Wang X, Xiang Y, Lu T, He Y, Shang T, Zhu Q, Wang X, Zeng Q, Zhang H, Li D
Journal of cellular and molecular medicine 2019 Dec;23(12):8090-8100

Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.

Zhong X, Cui P, Cai Y, Wang L, He X, Long P, Lu K, Yan R, Zhang Y, Pan X, Zhao X, Li W, Zhang H, Zhou Q, Gao P
Cell metabolism 2019 Apr 2;29(4):979-992.e4

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with 21584-1-AP( DLL4 Antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The DLL4 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human DLL4. This antibody recognizes human, mouse antigen. The DLL4 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 21584-1-AP.pdf

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