Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 11-10033-25 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-DLL4 Antibody
- Antibody type
- Polyclonal
- Description
- Dll4 (Delta-like 4), a membrane-bound Notch ligand, plays a fundamental role in vascular development and angiogenesis. It is highly expressed in capillary endothelial tip cells and is involved in suppressing neighboring stalk cells to become tip cells during angiogenesis. Dll4-Notch signaling is mediated either by direct cell-cell contact or by Dll4 Containing exosomes from a distance. DLL4 signaling is extensively critical for tumor angiogenesis. Blockage of DLL4 signaling inhibits tumor growth by deregulating angiogenesis and promoting non productive angiogenesis. Additionally, DLL4 has been shown to help regulate the cellular actions of VEGF.
- Reactivity
- Human
- Host
- Rabbit
- Antigen sequence
A partial length recombinant DLL4 p
rotein (amino acids 423-650) was us
ed as the immunogen for this antibo
dy.- Vial size
- 25 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
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Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Expression analysis of DLL4. Anti-DLL4 antibody (11-10033) was used at 2 µg/ml on A549 lysate.