Antibody data

Product number
320815 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#320815, RRID:AB_2562746
Product name
Brilliant Violet 510™ anti-human CD314 (NKG2D)
Antibody type
Monoclonal
Antigen
0
Description
CD314 is a homodimeric C-type lectin-like protein also known as NKG2D. It is expressed on NK cells, CD8+ T cells, γ/δ T cells, and in vitro induced LAK cells. Several molecules have been identified as the ligands for NKG2D, including MHC class-I chain-related protein A (MICA), MICB, and UL16-binding proteins (ULBPs). NKG2D has no intrinsic signaling capacity, but attains this by non-covalent association with DAP10 or DAP12 adaptors. In addition to being a primary activation receptor on NK cells, NKG2D is also a costimulatory receptor for TCR-mediated T cell proliferation and cytokine production. The interaction of NKG2D with its ligands plays a role in the immune surveillance against pathogen and tumor cells, and in the pathogenesis of autoimmune diseases.
Reactivity
Human
Host
Mouse
Conjugate
Yellow dye
Antibody clone number
1D11
Vial size
25 tests
Storage
2°C-8°C
Handling
Ambient RT
KLRC4-KLRK1 protein structure - 320815 shown in red.