320809

antibody from BioLegend

Targeting: KLRC4-KLRK1

Immunoprecipitation

Functional assay

Antibody data

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Validation data

Product number: 320809 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#320809, RRID:AB_492964
Product name: LEAF™ purified anti-human CD314 (NKG2D) [1D11]
Antibody type: Monoclonal
Antigen: CD314 (NKG2D)
Description: NKG2D is a homodimeric C-type lectin-like protein also known as CD314. It is expressed on NK cells, CD8+ T cells, ????/???? T cells, and in vitro induced LAK cells. Several molecules have been identified as the ligands for NKG2D, including MHC class-I chain-related protein A (MICA), MICB, UL16-binding proteins (ULBPs). NKG2D has no intrinsic signaling capacity, but attains this by non-covalent association with DAP10 or DAP12 adaptors. In addition to be a primary activation receptor on NK cells, NKG2D is also a costimulatory receptor for TCR-mediated T cell proliferation and cytokine production. The interaction of NKG2D with its ligands plays a role in the immune surveillance against pathogen and tumor cells, and in the pathogenesis of autoimmune diseases. The 1D11 antibody blocks MICA binding to T cells, induces redirected lysis, and costimulates T cells activation and proliferation.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Vial size: 50 µg
Concentration: 1 mg/ml
Storage: The antibody solution should be stored undiluted at 4 °C. This LEAF™ solution contains no preservative; handle under aseptic conditions.

KLRC4-KLRK1 protein structure - 320809 shown in red.