Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations [0]
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- Product number
- ABIN362125 - Provider product page
- Provider
- antibodies-online
- Proper citation
- Antibodies-Online Cat#ABIN362125, RRID:AB_10955346
- Product name
- anti-Forkhead Box O4 (FOXO4) (pSer197) antibody
- Antibody type
- Polyclonal
- Antigen
- Peptide sequence around phosphorylation site of pSer197 (A-A-S (p) -M-D) derived from Human AFX. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
- Description
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- pSer197
- Isotype
- IgG
- Vial size
- 50 μL
- Concentration
- 1 mg/mL
- Storage
- Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Submitted references Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease.
Activation of Akt/FoxO signaling pathway contributes to induction of neuroprotection against transient global cerebral ischemia by hypoxic pre-conditioning in adult rats.
Protein kinase CK2 phosphorylates and upregulates Akt/PKB.
Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.
Direct control of the Forkhead transcription factor AFX by protein kinase B.
Pierce A, Podlutskaya N, Halloran JJ, Hussong SA, Lin PY, Burbank R, Hart MJ, Galvan V
Journal of neurochemistry 2013 Mar;124(6):880-93
Journal of neurochemistry 2013 Mar;124(6):880-93
Activation of Akt/FoxO signaling pathway contributes to induction of neuroprotection against transient global cerebral ischemia by hypoxic pre-conditioning in adult rats.
Zhan L, Wang T, Li W, Xu ZC, Sun W, Xu E
Journal of neurochemistry 2010 Aug;114(3):897-908
Journal of neurochemistry 2010 Aug;114(3):897-908
Protein kinase CK2 phosphorylates and upregulates Akt/PKB.
Di Maira G, Salvi M, Arrigoni G, Marin O, Sarno S, Brustolon F, Pinna LA, Ruzzene M
Cell death and differentiation 2005 Jun;12(6):668-77
Cell death and differentiation 2005 Jun;12(6):668-77
Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.
Brownawell AM, Kops GJ, Macara IG, Burgering BM
Molecular and cellular biology 2001 May;21(10):3534-46
Molecular and cellular biology 2001 May;21(10):3534-46
Direct control of the Forkhead transcription factor AFX by protein kinase B.
Kops GJ, de Ruiter ND, De Vries-Smits AM, Powell DR, Bos JL, Burgering BM
Nature 1999 Apr 15;398(6728):630-4
Nature 1999 Apr 15;398(6728):630-4
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