Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Other assay [2]
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- Product number
- BMS1033 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- VAP-1 Monoclonal Antibody (TK8-14), eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: VAP-1 (TK8-14) is a mouse monoclonal antibody raised against affinity purifiedVAP-1 from tonsil stroma of human origin. Lymphocyte binding to vascular endothelium is a prerequisite for the move-ment of immune cells from the blood into lymphoid tissues and into sites ofinflammation. Under inflammatory conditions, cell surface expression ofVAP-1 (vascular adhesion protein-1) which is an endothelial sialoglycoprotein,is induced. VAP-1 is a type II transmembrane protein of 84.6 kDa with a singletransmembrane domain and N and O-glycosylation sites in the extracellulardomain. In vivo, VAP-1 exists predominantly as a 180 kDa homodimer andfunctions both as an enzyme (monoamine oxidase) and an adhesion moleculefor lymphocytes. Applications Tested: ELISA, Flow Cytometry, Immunofluorescence, Western Blotting.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- TK8-14
- Vial size
- 100 µg
- Concentration
- 1 mg/mL
- Storage
- -20°C
Submitted references Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis.
Weston CJ, Shepherd EL, Claridge LC, Rantakari P, Curbishley SM, Tomlinson JW, Hubscher SG, Reynolds GM, Aalto K, Anstee QM, Jalkanen S, Salmi M, Smith DJ, Day CP, Adams DH
The Journal of clinical investigation 2015 Feb;125(2):501-20
The Journal of clinical investigation 2015 Feb;125(2):501-20
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Supportive validation
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- Invitrogen Antibodies (provider)
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- Experimental details
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- Invitrogen Antibodies (provider)
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- Experimental details
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