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- Antibody Data
- Antigen structure
- References [32]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 12587-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12587-1-AP, RRID:AB_2162296
- Product name
- PDCD4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PDCD4 antibody (Cat. #12587-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Knockdown of programmed cell death factor 4 restores erectile function by attenuating apoptosis in rats with bilateral cavernous nerve crush injury.
Programmed cell death factor 4-mediated hippocampal synaptic plasticity is involved in early life stress and susceptibility to depression.
Hyaluronan-CD44 Interaction Regulates Mouse Retinal Progenitor Cells Migration, Proliferation and Neuronal Differentiation.
Cold exposure protects against medial arterial calcification development via autophagy.
Protective Effects of PPARγ on Renal Ischemia-Reperfusion Injury by Regulating miR-21.
Phosphoproteome reveals molecular mechanisms of aberrant rhythm in neurotransmitter-mediated islet hormone secretion in diabetic mice.
Pdcd4 promotes lipid deposition by attenuating PPARα-mediated fatty acid oxidation in hepatocytes.
PDCD4-mediated downregulation of Listeria monocytogenes burden in macrophages.
miR-21-5p inhibits inflammation injuries in LPS-treated H9c2 cells by regulating PDCD4.
Elevated microRNA-21 Is a Brake of Inflammation Involved in the Development of Nasal Polyps.
Repressing PDCD4 activates JNK/ABCG2 pathway to induce chemoresistance to fluorouracil in colorectal cancer cells.
Delivery of microRNA-21-sponge and pre-microRNA-122 by MS2 virus-like particles to therapeutically target hepatocellular carcinoma cells.
Shear stress inhibits cardiac microvascular endothelial cells apoptosis to protect against myocardial ischemia reperfusion injury via YAP/miR-206/PDCD4 signaling pathway.
miR-21a in exosomes from Lewis lung carcinoma cells accelerates tumor growth through targeting PDCD4 to enhance expansion of myeloid-derived suppressor cells.
Pao Pereira extract suppresses benign prostatic hyperplasia by inhibiting inflammation-associated NFκB signaling.
MicroRNA‑21 serves an important role during PAOO‑facilitated orthodontic tooth movement.
Forkhead box P3 promotes breast cancer cell apoptosis by regulating programmed cell death 4 expression.
Localized injection of miRNA-21-enriched extracellular vesicles effectively restores cardiac function after myocardial infarction.
Inhibition of MCF-7 breast cancer cell proliferation by a synthetic peptide derived from the C-terminal sequence of Orai channel.
Long non-coding RNA SNHG1 functions as a competitive endogenous RNA to regulate PDCD4 expression by sponging miR-195-5p in hepatocellular carcinoma.
Upregulation of miR-96 promotes radioresistance in glioblastoma cells via targeting PDCD4.
MiR-208a-3p aggravates autophagy through the PDCD4-ATG5 pathway in Ang II-induced H9c2 cardiomyoblasts.
Lung adenocarcinoma cell-derived exosomal miR-21 facilitates osteoclastogenesis.
Combination of Rapamycin and Resveratrol for Treatment of Bladder Cancer.
Ischemic Postconditioning-Regulated miR-499 Protects the Rat Heart Against Ischemia/Reperfusion Injury by Inhibiting Apoptosis through PDCD4.
Tetramethylpyrazine enhances functional recovery after contusion spinal cord injury by modulation of MicroRNA-21, FasL, PDCD4 and PTEN expression.
Reduced PDCD4 Expression Promotes Cell Growth Through PI3K/Akt Signaling in Non-Small Cell Lung Cancer.
Effects of combining rapamycin and resveratrol on apoptosis and growth of TSC2-deficient xenograft tumors.
The combination of rapamycin and resveratrol blocks autophagy and induces apoptosis in breast cancer cells.
Resveratrol prevents rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells.
Anti-apoptotic effect of microRNA-21 after contusion spinal cord injury in rats.
miR-183 inhibits TGF-beta1-induced apoptosis by downregulation of PDCD4 expression in human hepatocellular carcinoma cells.
Ge Y, Xia T, Feng Z, Xi Y, Hu D, Hong Y, Tang B, Wu J, Chen J, Xiao H
Andrology 2024 Sep;12(6):1439-1448
Andrology 2024 Sep;12(6):1439-1448
Programmed cell death factor 4-mediated hippocampal synaptic plasticity is involved in early life stress and susceptibility to depression.
Cheng J, Yuan L, Yu S, Gu B, Luo Q, Wang X, Zhao Y, Gai C, Li T, Liu W, Wang Z, Liu D, Ho RCM, Ho CSH
Behavioural brain research 2024 Jun 25;468:115028
Behavioural brain research 2024 Jun 25;468:115028
Hyaluronan-CD44 Interaction Regulates Mouse Retinal Progenitor Cells Migration, Proliferation and Neuronal Differentiation.
Ma J, Fang X, Chen M, Wang Y, Zhang L
Stem cell reviews and reports 2023 Nov;19(8):2929-2942
Stem cell reviews and reports 2023 Nov;19(8):2929-2942
Cold exposure protects against medial arterial calcification development via autophagy.
Li FX, Liu JJ, Xu F, Shan SK, Zheng MH, Lei LM, Lin X, Guo B, Li CC, Wu F, Tang KX, Cao YC, Wu YY, Duan JY, Wu YL, He SY, Chen X, Yuan LQ
Journal of nanobiotechnology 2023 Jul 17;21(1):226
Journal of nanobiotechnology 2023 Jul 17;21(1):226
Protective Effects of PPARγ on Renal Ischemia-Reperfusion Injury by Regulating miR-21.
Huang R, Zou C, Zhang C, Wang X, Zou X, Xiang Z, Wang Z, Gui B, Lin T, Hu H
Oxidative medicine and cellular longevity 2022;2022:7142314
Oxidative medicine and cellular longevity 2022;2022:7142314
Phosphoproteome reveals molecular mechanisms of aberrant rhythm in neurotransmitter-mediated islet hormone secretion in diabetic mice.
He Y, Fu Q, Sun M, Qian Y, Liang Y, Zhang J, Gao R, Jiang H, Dai H, Liu Y, Xu X, Chen H, Xu K, Yang T
Clinical and translational medicine 2022 Jun;12(6):e890
Clinical and translational medicine 2022 Jun;12(6):e890
Pdcd4 promotes lipid deposition by attenuating PPARα-mediated fatty acid oxidation in hepatocytes.
Du X, Osoro EK, Chen Q, Yan X, Gao D, Wu L, Ren J, Feng L, Wu N, Lu K, Yang X, Zhong B, Han Y, Zhang F, Li D, Lan X, Lu S
Molecular and cellular endocrinology 2022 Apr 5;545:111562
Molecular and cellular endocrinology 2022 Apr 5;545:111562
PDCD4-mediated downregulation of Listeria monocytogenes burden in macrophages.
Zhang X, Zhang J, Li F, Luo Y, Jiang S
Central-European journal of immunology 2021;46(1):38-46
Central-European journal of immunology 2021;46(1):38-46
miR-21-5p inhibits inflammation injuries in LPS-treated H9c2 cells by regulating PDCD4.
Xue J, Liu J, Xu B, Yu J, Zhang A, Qin L, Liu C, Yang Y
American journal of translational research 2021;13(10):11450-11460
American journal of translational research 2021;13(10):11450-11460
Elevated microRNA-21 Is a Brake of Inflammation Involved in the Development of Nasal Polyps.
Liu R, Du J, Zhou J, Zhong B, Ba L, Zhang J, Liu Y, Liu S
Frontiers in immunology 2021;12:530488
Frontiers in immunology 2021;12:530488
Repressing PDCD4 activates JNK/ABCG2 pathway to induce chemoresistance to fluorouracil in colorectal cancer cells.
Hu L, Liang Y, Wu K, Wang C, Zhang T, Peng R, Zou F
Annals of translational medicine 2021 Jan;9(2):114
Annals of translational medicine 2021 Jan;9(2):114
Delivery of microRNA-21-sponge and pre-microRNA-122 by MS2 virus-like particles to therapeutically target hepatocellular carcinoma cells.
Zhang J, Li D, Zhang R, Peng R, Li J
Experimental biology and medicine (Maywood, N.J.) 2021 Dec;246(23):2463-2472
Experimental biology and medicine (Maywood, N.J.) 2021 Dec;246(23):2463-2472
Shear stress inhibits cardiac microvascular endothelial cells apoptosis to protect against myocardial ischemia reperfusion injury via YAP/miR-206/PDCD4 signaling pathway.
Zhang Q, Cao Y, Liu Y, Huang W, Ren J, Wang P, Song C, Fan K, Ba L, Wang L, Sun H
Biochemical pharmacology 2021 Apr;186:114466
Biochemical pharmacology 2021 Apr;186:114466
miR-21a in exosomes from Lewis lung carcinoma cells accelerates tumor growth through targeting PDCD4 to enhance expansion of myeloid-derived suppressor cells.
Zhang X, Li F, Tang Y, Ren Q, Xiao B, Wan Y, Jiang S
Oncogene 2020 Oct;39(40):6354-6369
Oncogene 2020 Oct;39(40):6354-6369
Pao Pereira extract suppresses benign prostatic hyperplasia by inhibiting inflammation-associated NFκB signaling.
Dong Y, Liu J, Xue Z, Sun J, Huang Z, Jing Y, Han B, Shen B, Yan J, Huang R
BMC complementary medicine and therapies 2020 May 16;20(1):150
BMC complementary medicine and therapies 2020 May 16;20(1):150
MicroRNA‑21 serves an important role during PAOO‑facilitated orthodontic tooth movement.
Zhang Y, Tian Y, Yang X, Zhao Z, Feng C, Zhang Y
Molecular medicine reports 2020 Jul;22(1):474-482
Molecular medicine reports 2020 Jul;22(1):474-482
Forkhead box P3 promotes breast cancer cell apoptosis by regulating programmed cell death 4 expression.
Fan D, Zeng C, Wang S, Han J, Zhu L, Zhao H, Zhang Y, Lu J, Xu Y
Oncology letters 2020 Dec;20(6):292
Oncology letters 2020 Dec;20(6):292
Localized injection of miRNA-21-enriched extracellular vesicles effectively restores cardiac function after myocardial infarction.
Song Y, Zhang C, Zhang J, Jiao Z, Dong N, Wang G, Wang Z, Wang L
Theranostics 2019;9(8):2346-2360
Theranostics 2019;9(8):2346-2360
Inhibition of MCF-7 breast cancer cell proliferation by a synthetic peptide derived from the C-terminal sequence of Orai channel.
Li S, Yao M, Niu C, Liu D, Tang Z, Gu C, Zhao H, Ke J, Wu S, Wang X, Wu F
Biochemical and biophysical research communications 2019 Sep 3;516(4):1066-1072
Biochemical and biophysical research communications 2019 Sep 3;516(4):1066-1072
Long non-coding RNA SNHG1 functions as a competitive endogenous RNA to regulate PDCD4 expression by sponging miR-195-5p in hepatocellular carcinoma.
Huang D, Wei Y, Zhu J, Wang F
Gene 2019 Sep 25;714:143994
Gene 2019 Sep 25;714:143994
Upregulation of miR-96 promotes radioresistance in glioblastoma cells via targeting PDCD4.
Guo P, Yu Y, Tian Z, Lin Y, Qiu Y, Yao W, Zhang L
International journal of oncology 2018 Oct;53(4):1591-1600
International journal of oncology 2018 Oct;53(4):1591-1600
MiR-208a-3p aggravates autophagy through the PDCD4-ATG5 pathway in Ang II-induced H9c2 cardiomyoblasts.
Wang L, Ye N, Lian X, Peng F, Zhang H, Gong H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Feb;98:1-8
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Feb;98:1-8
Lung adenocarcinoma cell-derived exosomal miR-21 facilitates osteoclastogenesis.
Xu Z, Liu X, Wang H, Li J, Dai L, Li J, Dong C
Gene 2018 Aug 5;666:116-122
Gene 2018 Aug 5;666:116-122
Combination of Rapamycin and Resveratrol for Treatment of Bladder Cancer.
Alayev A, Salamon RS, Schwartz NS, Berman AY, Wiener SL, Holz MK
Journal of cellular physiology 2017 Feb;232(2):436-446
Journal of cellular physiology 2017 Feb;232(2):436-446
Ischemic Postconditioning-Regulated miR-499 Protects the Rat Heart Against Ischemia/Reperfusion Injury by Inhibiting Apoptosis through PDCD4.
Zhu J, Yao K, Wang Q, Guo J, Shi H, Ma L, Liu H, Gao W, Zou Y, Ge J
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;39(6):2364-2380
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;39(6):2364-2380
Tetramethylpyrazine enhances functional recovery after contusion spinal cord injury by modulation of MicroRNA-21, FasL, PDCD4 and PTEN expression.
Huang JH, Cao Y, Zeng L, Wang G, Cao M, Lu HB, Hu JZ
Brain research 2016 Oct 1;1648(Pt A):35-45
Brain research 2016 Oct 1;1648(Pt A):35-45
Reduced PDCD4 Expression Promotes Cell Growth Through PI3K/Akt Signaling in Non-Small Cell Lung Cancer.
Zhen Y, Li D, Li W, Yao W, Wu A, Huang J, Gu H, Huang Y, Wang Y, Wu J, Chen M, Wu D, Lyu Q, Fang W, Wu B
Oncology research 2016 Jan 21;23(1-2):61-8
Oncology research 2016 Jan 21;23(1-2):61-8
Effects of combining rapamycin and resveratrol on apoptosis and growth of TSC2-deficient xenograft tumors.
Alayev A, Salamon RS, Sun Y, Schwartz NS, Li C, Yu JJ, Holz MK
American journal of respiratory cell and molecular biology 2015 Nov;53(5):637-46
American journal of respiratory cell and molecular biology 2015 Nov;53(5):637-46
The combination of rapamycin and resveratrol blocks autophagy and induces apoptosis in breast cancer cells.
Alayev A, Berger SM, Kramer MY, Schwartz NS, Holz MK
Journal of cellular biochemistry 2015 Mar;116(3):450-7
Journal of cellular biochemistry 2015 Mar;116(3):450-7
Resveratrol prevents rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells.
Alayev A, Sun Y, Snyder RB, Berger SM, Yu JJ, Holz MK
Cell cycle (Georgetown, Tex.) 2014;13(3):371-82
Cell cycle (Georgetown, Tex.) 2014;13(3):371-82
Anti-apoptotic effect of microRNA-21 after contusion spinal cord injury in rats.
Hu JZ, Huang JH, Zeng L, Wang G, Cao M, Lu HB
Journal of neurotrauma 2013 Aug 1;30(15):1349-60
Journal of neurotrauma 2013 Aug 1;30(15):1349-60
miR-183 inhibits TGF-beta1-induced apoptosis by downregulation of PDCD4 expression in human hepatocellular carcinoma cells.
Li J, Fu H, Xu C, Tie Y, Xing R, Zhu J, Qin Y, Sun Z, Zheng X
BMC cancer 2010 Jul 6;10:354
BMC cancer 2010 Jul 6;10:354
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 12587-1-AP(PDCD4 antibody) at dilution of 1:3000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PDCD4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PDCD4. This antibody recognizes human, mouse, rat antigen. The PDCD4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
