Antibody data
- Antibody Data
- Antigen structure
- References [20]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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- Product number
- 10975-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10975-2-AP, RRID:AB_2153760
- Product name
- Nurr1/NR4A2 antibody
- Antibody type
- Polyclonal
- Description
- Nurr1/NR4A2 antibody (Cat. #10975-2-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Human neural stem cells promote mitochondrial genesis to alleviate neuronal damage in MPTP-induced cynomolgus monkey models.
Promoting collateral formation in type 2 diabetes mellitus using ultra-small nanodots with autophagy activation and ROS scavenging.
A Graphene Composite Film Based Wearable Far-Infrared Therapy Apparatus (GRAFT) for Effective Prevention of Postoperative Peritoneal Adhesion.
The role of NF-κB signaling pathway in reactive astrocytes among neurodegeneration after methamphetamine exposure by integrated bioinformatics.
The Synergistic Effect Study of Lipopolysaccharide (LPS) and A53T-α-Synuclein: Intranasal LPS Exposure on the A53T-α-Synuclein Transgenic Mouse Model of Parkinson's Disease.
Single-nuclei RNA sequencing uncovers heterogenous transcriptional signatures in Parkinson's disease associated with nuclear receptor-related factor 1 defect.
Protective effect of Nr4a2 (Nurr1) against LPS-induced depressive-like behaviors via regulating activity of microglia and CamkII neurons in anterior cingulate cortex.
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma.
LincRNA-p21 Upregulates Nuclear Orphan Receptor Nr4a2 and Aggravates Myocardial Ischemia/Reperfusion Injury via Targeting MiR-466i-5p.
Itaconate Attenuates Neuroinflammation and Exerts Dopamine Neuroprotection in Parkinson's Disease through Inhibiting NLRP3 Inflammasome.
Transfer of neuron-derived α-synuclein to astrocytes induces neuroinflammation and blood-brain barrier damage after methamphetamine exposure: Involving the regulation of nuclear receptor-associated protein 1.
Dopamine-related oxidative stress and mitochondrial dysfunction in dopaminergic neurons differentiated from deciduous teeth-derived stem cells of children with Down syndrome.
Caveolin-1 facilitates cell migration by upregulating nuclear receptor 4A2/retinoid X receptor α-mediated β-galactoside α2,6-sialyltransferase I expression in human hepatocarcinoma cells.
Pramipexole attenuates 6-OHDA-induced Parkinson's disease by mediating the Nurr1/NF-κB pathway.
Attenuated macrophage activation mediated by microRNA-183 knockdown through targeting NR4A2.
Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Can Extensively Differentiate to Tyrosine-Hydroxylase-Expressing Dopamine-Secreting Neurons.
Wnt1 silencing enhances neurotoxicity induced by paraquat and maneb in SH-SY5Y cells.
Correlation between Nurr1 expression and drug resistance in the brain of rats with epilepsy.
miR-206 modulates lipopolysaccharide-mediated inflammatory cytokine production in human astrocytes.
Identification of low intratumoral gene expression heterogeneity in neuroblastic tumors by genome-wide expression analysis and game theory.
He Y, Li R, Yu Y, Huang C, Xu Z, Wang T, Chen M, Huang H, Qi Z
Neurochemistry international 2024 May;175:105700
Neurochemistry international 2024 May;175:105700
Promoting collateral formation in type 2 diabetes mellitus using ultra-small nanodots with autophagy activation and ROS scavenging.
Wang Y, Li F, Mao L, Liu Y, Chen S, Liu J, Huang K, Chen Q, Wu J, Lu L, Zheng Y, Shen W, Ying T, Dai Y, Shen Y
Journal of nanobiotechnology 2024 Mar 1;22(1):85
Journal of nanobiotechnology 2024 Mar 1;22(1):85
A Graphene Composite Film Based Wearable Far-Infrared Therapy Apparatus (GRAFT) for Effective Prevention of Postoperative Peritoneal Adhesion.
Lu X, Xu L, Song Y, Yu X, Li Q, Liu F, Li X, Xi J, Wang S, Wang L, Wang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(22):e2309330
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(22):e2309330
The role of NF-κB signaling pathway in reactive astrocytes among neurodegeneration after methamphetamine exposure by integrated bioinformatics.
Li K, Ling H, Wang X, Xie Q, Gu C, Luo W, Qiu P
Progress in neuro-psychopharmacology & biological psychiatry 2024 Feb 8;129:110909
Progress in neuro-psychopharmacology & biological psychiatry 2024 Feb 8;129:110909
The Synergistic Effect Study of Lipopolysaccharide (LPS) and A53T-α-Synuclein: Intranasal LPS Exposure on the A53T-α-Synuclein Transgenic Mouse Model of Parkinson's Disease.
He Q, Zhang S, Wang J, Ma T, Ma D, Wu L, Zhou M, Zhao L, Chen Y, Liu J, Chen W
Molecular neurobiology 2024 Feb 17;
Molecular neurobiology 2024 Feb 17;
Single-nuclei RNA sequencing uncovers heterogenous transcriptional signatures in Parkinson's disease associated with nuclear receptor-related factor 1 defect.
Kambey PA, Liu WY, Wu J, Bosco B, Nadeem I, Kanwore K, Gao DS
Neural regeneration research 2023 Sep;18(9):2037-2046
Neural regeneration research 2023 Sep;18(9):2037-2046
Protective effect of Nr4a2 (Nurr1) against LPS-induced depressive-like behaviors via regulating activity of microglia and CamkII neurons in anterior cingulate cortex.
He Y, Wang Y, Yu H, Tian Y, Chen X, Chen C, Ren Y, Chen Z, Ren Y, Gong X, Cheng K, Liu X, Zhong L, Guo Y, Xie P
Pharmacological research 2023 May;191:106717
Pharmacological research 2023 May;191:106717
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma.
Ye Z, Ai X, Yang K, Yang Z, Fei F, Liao X, Qiu Z, Gimple RC, Yuan H, Huang H, Gong Y, Xiao C, Yue J, Huang L, Saulnier O, Wang W, Zhang P, Dai L, Wang X, Wang X, Ahn YH, You C, Xu J, Wan X, Taylor MD, Zhao L, Rich JN, Zhou S
Cancer discovery 2023 Apr 3;13(4):974-1001
Cancer discovery 2023 Apr 3;13(4):974-1001
LincRNA-p21 Upregulates Nuclear Orphan Receptor Nr4a2 and Aggravates Myocardial Ischemia/Reperfusion Injury via Targeting MiR-466i-5p.
Zhai X, Liu R, Li J, Wang F, Liu L, Wei S, Bian Y, Pang J, Xue M, Qin D, Wang S, Xu T, Xu F, Cao S, Yuan Q, Chen Y
International heart journal 2022;63(5):1004-1014
International heart journal 2022;63(5):1004-1014
Itaconate Attenuates Neuroinflammation and Exerts Dopamine Neuroprotection in Parkinson's Disease through Inhibiting NLRP3 Inflammasome.
Sun G, Zhang R, Liu C, Meng W, Pang Q
Brain sciences 2022 Sep 16;12(9)
Brain sciences 2022 Sep 16;12(9)
Transfer of neuron-derived α-synuclein to astrocytes induces neuroinflammation and blood-brain barrier damage after methamphetamine exposure: Involving the regulation of nuclear receptor-associated protein 1.
Huang J, Ding J, Wang X, Gu C, He Y, Li Y, Fan H, Xie Q, Qi X, Wang Z, Qiu P
Brain, behavior, and immunity 2022 Nov;106:247-261
Brain, behavior, and immunity 2022 Nov;106:247-261
Dopamine-related oxidative stress and mitochondrial dysfunction in dopaminergic neurons differentiated from deciduous teeth-derived stem cells of children with Down syndrome.
Sun X, Kato H, Sato H, Han X, Hirofuji Y, Kato TA, Sakai Y, Ohga S, Fukumoto S, Masuda K
FASEB bioAdvances 2022 Jul;4(7):454-467
FASEB bioAdvances 2022 Jul;4(7):454-467
Caveolin-1 facilitates cell migration by upregulating nuclear receptor 4A2/retinoid X receptor α-mediated β-galactoside α2,6-sialyltransferase I expression in human hepatocarcinoma cells.
Chen X, Wang L, Yu X, Wang S, Zhang J
The international journal of biochemistry & cell biology 2021 Aug;137:106027
The international journal of biochemistry & cell biology 2021 Aug;137:106027
Pramipexole attenuates 6-OHDA-induced Parkinson's disease by mediating the Nurr1/NF-κB pathway.
Gao H, Wang D, Wang YL, Mao JP, Jiang S, Yang XL
Molecular biology reports 2021 Apr;48(4):3079-3087
Molecular biology reports 2021 Apr;48(4):3079-3087
Attenuated macrophage activation mediated by microRNA-183 knockdown through targeting NR4A2.
Gong FH, Long L, Yang YS, Shen DH, Zhang YS, Wang XS, Zhang XP, Xiao XQ
Experimental and therapeutic medicine 2021 Apr;21(4):300
Experimental and therapeutic medicine 2021 Apr;21(4):300
Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Can Extensively Differentiate to Tyrosine-Hydroxylase-Expressing Dopamine-Secreting Neurons.
Yamane M, Takaoka N, Obara K, Shirai K, Aki R, Hamada Y, Arakawa N, Hoffman RM, Amoh Y
Cells 2021 Apr 10;10(4)
Cells 2021 Apr 10;10(4)
Wnt1 silencing enhances neurotoxicity induced by paraquat and maneb in SH-SY5Y cells.
Huang C, Ma J, Li BX, Sun Y
Experimental and therapeutic medicine 2019 Nov;18(5):3643-3649
Experimental and therapeutic medicine 2019 Nov;18(5):3643-3649
Correlation between Nurr1 expression and drug resistance in the brain of rats with epilepsy.
Li HY, Liu F, Wang HR
European review for medical and pharmacological sciences 2018 Mar;22(5):1506-1513
European review for medical and pharmacological sciences 2018 Mar;22(5):1506-1513
miR-206 modulates lipopolysaccharide-mediated inflammatory cytokine production in human astrocytes.
Duan X, Zohaib A, Li Y, Zhu B, Ye J, Wan S, Xu Q, Song Y, Chen H, Cao S
Cellular signalling 2015 Jan;27(1):61-8
Cellular signalling 2015 Jan;27(1):61-8
Identification of low intratumoral gene expression heterogeneity in neuroblastic tumors by genome-wide expression analysis and game theory.
Albino D, Scaruffi P, Moretti S, Coco S, Truini M, Di Cristofano C, Cavazzana A, Stigliani S, Bonassi S, Tonini GP
Cancer 2008 Sep 15;113(6):1412-22
Cancer 2008 Sep 15;113(6):1412-22
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Supportive validation
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- Proteintech Group (provider)
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- Experimental details
- The Nurr1/NR4A2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Nurr1/NR4A2. This antibody recognizes human antigen. The Nurr1/NR4A2 antibody has been validated for the following applications: ELISA, IHC analysis.