10975-2-AP

antibody from Proteintech Group

Targeting: NR4A2 HZF-3, NOT, NURR1, RNR1, TINUR

Provider product page for 10975-2-AP

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Antibody data

Antibody Data
Antigen structure
References [32]
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Validations
Immunohistochemistry [1]

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Product number: 10975-2-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10975-2-AP, RRID:AB_2153760
Product name: Nurr1/NR4A2 antibody
Antibody type: Polyclonal
Description: Nurr1/NR4A2 antibody (Cat. #10975-2-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

NR4A2 protein structure - 10975-2-AP shown in red.

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The selenocysteine-containing protein SELENOT maintains dopamine signaling in the midbrain to protect mice from hyperactivity disorder.

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The endocannabinoid anandamide mediates anti-inflammatory effects through activation of NR4A nuclear receptors.

Teichmann T, Pflüger-Müller B, Giménez VMM, Sailer F, Dirks H, Zehr S, Warwick T, Brettner F, Munoz-Tello P, Zimmer A, Tegeder I, Thomas D, Gurke R, Günther S, Heering J, Proschak E, Geisslinger G, Bibli IS, Heringdorf DMZ, Manucha W, Windbergs M, Knapp S, Weigert A, Leisegang MS, Kojetin D, Brandes RP
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Dual nuclear receptor 4A1 (NR4A1/NR4A2) ligands inhibit glioblastoma growth and target TWIST1.

Upadhyay S, Lee M, Zhang L, Oany AR, Mikheeva SA, Mikheev AM, Rostomily RC, Safe S
Molecular pharmacology 2025 Feb;107(2):100009

Structurally Distinct Nurr1 Ligands Exhibit Different Pharmacological Characteristics in Regulating Inflammatory Responses of Microglial BV-2 Cells.

Nakanishi R, Kurauchi Y, Kotani S, Hitora-Imamura N, Seki T, Katsuki H
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The Synergistic Effect Study of Lipopolysaccharide (LPS) and A53T-α-Synuclein: Intranasal LPS Exposure on the A53T-α-Synuclein Transgenic Mouse Model of Parkinson's Disease.

He Q, Zhang S, Wang J, Ma T, Ma D, Wu L, Zhou M, Zhao L, Chen Y, Liu J, Chen W
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Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance.

Mao Y, Meng Y, Zou K, Qin N, Wang Y, Yan J, Chen P, Cheng Y, Shi W, Zhou C, Chen H, Sheng J, Liu X, Pan J, Huang H
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Ho DH, Kim H, Nam D, Seo MK, Park SW, Son I
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Nurr1 overexpression in the primary motor cortex alleviates motor dysfunction induced by intracerebral hemorrhage in the striatum in mice.

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Li K, Ling H, Wang X, Xie Q, Gu C, Luo W, Qiu P
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He Y, Li R, Yu Y, Xu Z, Gao J, Wang C, Huang C, Qi Z
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He Y, Wang Y, Yu H, Tian Y, Chen X, Chen C, Ren Y, Chen Z, Ren Y, Gong X, Cheng K, Liu X, Zhong L, Guo Y, Xie P
Pharmacological research 2023 May;191:106717

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Cancer discovery 2023 Apr 3;13(4):974-1001

LincRNA-p21 Upregulates Nuclear Orphan Receptor Nr4a2 and Aggravates Myocardial Ischemia/Reperfusion Injury via Targeting MiR-466i-5p.

Zhai X, Liu R, Li J, Wang F, Liu L, Wei S, Bian Y, Pang J, Xue M, Qin D, Wang S, Xu T, Xu F, Cao S, Yuan Q, Chen Y
International heart journal 2022;63(5):1004-1014

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Transfer of neuron-derived α-synuclein to astrocytes induces neuroinflammation and blood-brain barrier damage after methamphetamine exposure: Involving the regulation of nuclear receptor-associated protein 1.

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Wnt1 silencing enhances neurotoxicity induced by paraquat and maneb in SH-SY5Y cells.

Huang C, Ma J, Li BX, Sun Y
Experimental and therapeutic medicine 2019 Nov;18(5):3643-3649

Correlation between Nurr1 expression and drug resistance in the brain of rats with epilepsy.

Li HY, Liu F, Wang HR
European review for medical and pharmacological sciences 2018 Mar;22(5):1506-1513

miR-206 modulates lipopolysaccharide-mediated inflammatory cytokine production in human astrocytes.

Duan X, Zohaib A, Li Y, Zhu B, Ye J, Wan S, Xu Q, Song Y, Chen H, Cao S
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Identification of low intratumoral gene expression heterogeneity in neuroblastic tumors by genome-wide expression analysis and game theory.

Albino D, Scaruffi P, Moretti S, Coco S, Truini M, Di Cristofano C, Cavazzana A, Stigliani S, Bonassi S, Tonini GP
Cancer 2008 Sep 15;113(6):1412-22

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Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Nurr1/NR4A2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Nurr1/NR4A2. This antibody recognizes human antigen. The Nurr1/NR4A2 antibody has been validated for the following applications: ELISA, IHC analysis.
Appendix: 10975-2-AP.pdf

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