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- Antibody Data
- Antigen structure
- References [8]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 15072-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15072-1-AP, RRID:AB_2211507
- Product name
- TTBK2 antibody
- Antibody type
- Polyclonal
- Description
- TTBK2 antibody (Cat. #15072-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references XIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate HSC activation and liver fibrosis.
GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base.
NudCL2 is an autophagy receptor that mediates selective autophagic degradation of CP110 at mother centrioles to promote ciliogenesis.
Altered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive function.
Differential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repair.
Spinocerebellar ataxia type 11-associated alleles of Ttbk2 dominantly interfere with ciliogenesis and cilium stability.
MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment.
The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43.
Hong R, Tan Y, Tian X, Huang Z, Wang J, Ni H, Yang J, Bu W, Yang S, Li T, Yu F, Zhong W, Sun T, Wang X, Li D, Liu M, Yang Y, Zhou J
EMBO reports 2024 Mar;25(3):1055-1074
EMBO reports 2024 Mar;25(3):1055-1074
GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base.
Jang DG, Kwon KY, Kweon YC, Kim BG, Myung K, Lee HS, Young Park C, Kwon T, Park TJ
eLife 2022 Aug 25;11
eLife 2022 Aug 25;11
NudCL2 is an autophagy receptor that mediates selective autophagic degradation of CP110 at mother centrioles to promote ciliogenesis.
Liu M, Zhang W, Li M, Feng J, Kuang W, Chen X, Yang F, Sun Q, Xu Z, Hua J, Yang C, Liu W, Shu Q, Yang Y, Zhou T, Xie S
Cell research 2021 Nov;31(11):1199-1211
Cell research 2021 Nov;31(11):1199-1211
Altered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive function.
Flynn M, Whitton L, Donohoe G, Morrison CG, Morris DW
Human molecular genetics 2020 Feb 1;29(3):407-417
Human molecular genetics 2020 Feb 1;29(3):407-417
Differential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repair.
Khouj EM, Prosser SL, Tada H, Chong WM, Liao JC, Sugasawa K, Morrison CG
Journal of cell science 2019 Oct 3;132(19)
Journal of cell science 2019 Oct 3;132(19)
Spinocerebellar ataxia type 11-associated alleles of Ttbk2 dominantly interfere with ciliogenesis and cilium stability.
Bowie E, Norris R, Anderson KV, Goetz SC
PLoS genetics 2018 Dec;14(12):e1007844
PLoS genetics 2018 Dec;14(12):e1007844
MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment.
Lee SH, Lee MS, Choi TI, Hong H, Seo JY, Kim CH, Kim J
Scientific reports 2016 Jun 6;6:27284
Scientific reports 2016 Jun 6;6:27284
The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43.
Liachko NF, McMillan PJ, Strovas TJ, Loomis E, Greenup L, Murrell JR, Ghetti B, Raskind MA, Montine TJ, Bird TD, Leverenz JB, Kraemer BC
PLoS genetics 2014 Dec;10(12):e1004803
PLoS genetics 2014 Dec;10(12):e1004803
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- PC-3 cells were subjected to SDS PAGE followed by western blot with 15072-1-AP(TTBK2 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 15072-1-AP(TTBK2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TTBK2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TTBK2. This antibody recognizes human, mouse, rat antigen. The TTBK2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
