HPA000390

antibody from Atlas Antibodies

Targeting: AUTS2 FBRSL2, KIAA0442

Western blot (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

HPA000390

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA000390, RRID:AB_1845218

Product name

Anti-AUTS2

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human AUTS2, Gene description: autism susceptibility candidate 2, Alternative Gene Names: FBRSL2, KIAA0442, Validated applications: ICC, IHC, WB, Uniprot ID: Q8WXX7, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.2 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

Isolated loss of the AUTS2 long isoform, brain-wide or targeted to Calbindin-lineage cells, generates a specific suite of brain, behavioral, and molecular pathologies

Song Y, Seward C, Chen C, LeBlanc A, Leddy A, Stubbs L, Caspary T
GENETICS 2024;226(1)

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Cerebral organoids containing an AUTS2 missense variant model microcephaly

Fair S, Schwind W, Julian D, Biel A, Guo G, Rutherford R, Ramadesikan S, Westfall J, Miller K, Kararoudi M, Hickey S, Mosher T, McBride K, Neinast R, Fitch J, Lee D, White P, Wilson R, Bedrosian T, Koboldt D, Hester M
Brain 2023;146(1):387-404

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Auts2 deletion involves in DG hypoplasia and social recognition deficit: The developmental and neural circuit mechanisms

Li J, Sun X, You Y, Li Q, Wei C, Zhao L, Sun M, Meng H, Zhang T, Yue W, Wang L, Zhang D
Science Advances 2022;8(9)

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AUTS2 Regulates RNA Metabolism and Dentate Gyrus Development in Mice

Castanza A, Ramirez S, Tripathi P, Daza R, Kalume F, Ramirez J, Hevner R
Cerebral Cortex 2021

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A Mouse Mutation That Dysregulates NeighboringGalnt17andAuts2Genes Is Associated with Phenotypes Related to the Human AUTS2 Syndrome

Weisner P, Chen C, Sun Y, Yoo J, Kao W, Zhang H, Baltz E, Troy J, Stubbs L
G3 Genes|Genomes|Genetics 2019;9(11):3891-3906

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Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing

Parras A, Anta H, Santos-Galindo M, Swarup V, Elorza A, Nieto-González J, Picó S, Hernández I, Díaz-Hernández J, Belloc E, Rodolosse A, Parikshak N, Peñagarikano O, Fernández-Chacón R, Irimia M, Navarro P, Geschwind D, Méndez R, Lucas J
Nature 2018;560(7719):441-446

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Brain enhancer activities at the gene-poor 5p14.1 autism-associated locus.

Inoue YU, Inoue T
Scientific reports 2016 Aug 9;6:31227

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Genome-wide distribution of Auts2 binding localizes with active neurodevelopmental genes

Oksenberg N, Haliburton G, Eckalbar W, Oren I, Nishizaki S, Murphy K, Pollard K, Birnbaum R, Ahituv N
Translational Psychiatry 2014;4(9):e431-e431

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Cerebral organoids model human brain development and microcephaly

Lancaster M, Renner M, Martin C, Wenzel D, Bicknell L, Hurles M, Homfray T, Penninger J, Jackson A, Knoblich J
Nature 2013;501(7467):373-379

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Autism susceptibility candidate 2 (Auts2) encodes a nuclear protein expressed in developing brain regions implicated in autism neuropathology

Bedogni F, Hodge R, Nelson B, Frederick E, Shiba N, Daza R, Hevner R
Gene Expression Patterns 2010;10(1):9-15

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From Gene Expression Analysis to Tissue Microarrays

Ek S, Andréasson U, Hober S, Kampf C, Pontén F, Uhlén M, Merz H, Borrebaeck C
Molecular & Cellular Proteomics 2006;5(6):1072-1081