10992-1-AP

antibody from Proteintech Group

Targeting: CSNK2A1 Cka1, Cka2

Provider product page for 10992-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [26]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 10992-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10992-1-AP, RRID:AB_2245531
Product name: CSNK2A1 antibody
Antibody type: Polyclonal
Description: KD/KO validated CSNK2A1 antibody (Cat. #10992-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CSNK2A1 protein structure - 10992-1-AP shown in red.

Submitted references NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors.

Wang Y, Liu X, Zuo X, Wang C, Zhang Z, Zhang H, Zeng T, Chen S, Liu M, Chen H, Song Q, Li Q, Yang C, Le Y, Xing J, Zhang H, An J, Jia W, Kang L, Zhang H, Xie H, Ye J, Wu T, He F, Zhang X, Li Y, Zhou G
Cell genomics 2024 May 8;4(5):100550

CSNK2A1 confers gemcitabine resistance to pancreatic ductal adenocarcinoma via inducing autophagy.

Liu ZD, Shi YH, Xu QC, Zhao GY, Zhu YQ, Li FX, Ma MJ, Ye JY, Huang XT, Wang XY, Xu X, Wang JQ, Zhao W, Yin XY
Cancer letters 2024 Mar 31;585:216640

Epigenetic modification of TWIST1 in macrophages promotes hypertension-induced atherosclerotic plaque instability.

Sun Y, Yao J, Wang C, Jin Y, Wan X, Meng Q, Wu J, Liu Q, Sun H
International immunopharmacology 2024 Jan 25;127:111313

GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway.

Park AY, Leney-Greene M, Lynberg M, Gabrielski JQ, Xu X, Schwarz B, Zheng L, Balasubramaniyam A, Ham H, Chao B, Zhang Y, Matthews HF, Cui J, Yao Y, Kubo S, Chanchu JM, Morawski AR, Cook SA, Jiang P, Ravell JC, Cheng YH, George A, Faruqi A, Pagalilauan AM, Bergerson JRE, Ganesan S, Chauvin SD, Aluri J, Edwards-Hicks J, Bohrnsen E, Tippett C, Omar H, Xu L, Butcher GW, Pascall J, Karakoc-Aydiner E, Kiykim A, Maecker H, Tezcan İ, Esenboga S, Heredia RJ, Akata D, Tekin S, Kara A, Kuloglu Z, Unal E, Kendirli T, Dogu F, Karabiber E, Atkinson TP, Cochet C, Filhol O, Bosio CM, Davis MM, Lifton RP, Pearce EL, Daumke O, Aytekin C, Şahin GE, Aksu AÜ, Uzel G, Koneti Rao V, Sari S, Dalgıç B, Boztug K, Cagdas D, Haskologlu S, Ikinciogullari A, Schwefel D, Vilarinho S, Baris S, Ozen A, Su HC, Lenardo MJ
Nature immunology 2024 Feb;25(2):282-293

Multi-omics characterization of esophageal squamous cell carcinoma identifies molecular subtypes and therapeutic targets.

Zhao D, Guo Y, Wei H, Jia X, Zhi Y, He G, Nie W, Huang L, Wang P, Laster KV, Liu Z, Wang J, Lee MH, Dong Z, Liu K
JCI insight 2024 Apr 23;9(10)

CSNK2B modulates IRF1 binding to functional DNA elements and promotes basal and agonist-induced antiviral signaling.

Matsumoto M, Modliszewski JL, Shinozaki K, Maezawa R, Perez VM, Ishikawa Y, Suzuki R, McKnight KL, Masaki T, Hirai-Yuki A, Kohara M, Lemon SM, Selitsky SR, Yamane D
Nucleic acids research 2023 May 22;51(9):4451-4466

CircNDST1 promotes papillary thyroid cancer progression via its interaction with CSNK2A1 to activate the PI3K-Akt pathway and epithelial-mesenchymal transition.

Shu C, Wang S, Hu J, Xu M, Deng H, Maimaiti Y, Huang T
Journal of endocrinological investigation 2023 Mar;46(3):545-557

CX-4945 inhibits fibroblast-like synoviocytes functions through the CK2-p53 axis to reduce rheumatoid arthritis disease severity.

Luo Y, Lei Y, Guo X, Zhu D, Zhang H, Guo Z, Xu Z, Zhao H, Xi Y, Peng X, Xiao L, Wang Z, Niu X, Chen G
International immunopharmacology 2023 Jun;119:110163

Casein Kinase 2 Mediates HIV- and Opioid-Induced Pathologic Phosphorylation of TAR DNA Binding Protein 43 in the Basal Ganglia.

Ohene-Nyako M, Nass SR, Richard HT, Lukande R, Nicol MR, McRae M, Knapp PE, Hauser KF
ASN neuro 2023 Jan-Dec;15:17590914231158218

Inhibition of CK2/ING4 Pathway Facilitates Non-Small Cell Lung Cancer Immunotherapy.

Gou Q, Chen H, Chen M, Shi J, Jin J, Liu Q, Hou Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(34):e2304068

NCAPG promotes the proliferation of hepatocellular carcinoma through the CKII-dependent regulation of PTEN.

Zhang R, Ai J, Wang J, Sun C, Lu H, He A, Li M, Liao Y, Lei J, Zhou F, Wu L, Liao W
Journal of translational medicine 2022 Jul 21;20(1):325

CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis.

Guo Y, Zhu Z, Huang Z, Cui L, Yu W, Hong W, Zhou Z, Du P, Liu CY
Nature communications 2022 Aug 25;13(1):4995

ZWC complex-mediated SPT5 phosphorylation suppresses divergent antisense RNA transcription at active gene promoters.

Park K, Zhong J, Jang JS, Kim J, Kim HJ, Lee JH, Kim J
Nucleic acids research 2022 Apr 22;50(7):3835-3851

Lovastatin Alleviates α-Synuclein Aggregation and Phosphorylation in Cellular Models of Synucleinopathy.

Dai L, Wang J, He M, Xiong M, Tian Y, Liu C, Zhang Z
Frontiers in molecular neuroscience 2021;14:682320

Redox-sensitive activation of CCL7 by BRG1 in hepatocytes during liver injury.

Kong M, Dong W, Zhu Y, Fan Z, Miao X, Guo Y, Li C, Duan Y, Lu Y, Li Z, Xu Y
Redox biology 2021 Oct;46:102079

β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.

Lu Y, Li X, Liu H, Xue J, Zeng Z, Dong X, Zhang T, Wu G, Yang K, Xu S
Oncogene 2021 Feb;40(7):1269-1283

Structural insights into multifunctionality of human FACT complex subunit hSSRP1.

Li X, Li H, Jing Q, Wang M, Hu T, Li L, Zhang Q, Liu M, Fu YV, Han J, Su D
The Journal of biological chemistry 2021 Dec;297(6):101360

CSNK2A1-mediated phosphorylation of HMGA2 modulates cisplatin resistance in cervical cancer.

Shi Z, Wu D, Xu H, Yang J, Sun X
FEBS open bio 2021 Aug;11(8):2245-2255

CK2 kinase-mediated PHF8 phosphorylation controls TopBP1 stability to regulate DNA replication.

Feng H, Lu J, Song X, Thongkum A, Zhang F, Lou L, Reizes O, Almasan A, Gong Z
Nucleic acids research 2020 Nov 4;48(19):10940-10952

Long-wave Ultraviolet Ray Promotes Inflammation in Keloid-derived Fibroblasts by Activating P38-NFκB1 Signaling Pathway.

Niu X, Lin X, Chen X, Xu S, Huang Z, Tang Q
Journal of burn care & research : official publication of the American Burn Association 2020 Nov 30;41(6):1231-1239

β-catenin stimulates Tcf7l1 degradation through recruitment of casein kinase 2 in mouse embryonic stem cells.

Zhang Y, Zhu Z, Ding H, Wan S, Zhang X, Li Y, Ji J, Wang X, Zhang M, Ye SD
Biochemical and biophysical research communications 2020 Apr 2;524(2):280-287

Ginkgolic Acids Impair Mitochondrial Function by Decreasing Mitochondrial Biogenesis and Promoting FUNDC1-Dependent Mitophagy.

Wang W, Wang M, Ruan Y, Tan J, Wang H, Yang T, Li J, Zhou Q
Journal of agricultural and food chemistry 2019 Sep 11;67(36):10097-10106

The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H.

Yu G, Liao J, Wu J, Ding J, Zhang L
Bioscience, biotechnology, and biochemistry 2018 Oct;82(10):1694-1701

Lentivirus-mediated down-regulation of CK2α inhibits proliferation and induces apoptosis of malignant lymphoma and leukemia cells.

Jiang L, Zhang J, Hu N, Liu A, Zhu H, Li L, Tian Y, Chen X, Quan L
Biochemistry and cell biology = Biochimie et biologie cellulaire 2018 Dec;96(6):786-796

Increased expression of protein kinase CK2α correlates with poor patient prognosis in epithelial ovarian cancer.

Ma Z, Wang X, He J, Xia J, Li Y
PloS one 2017;12(3):e0174037

Protein kinase CK2α catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma.

Zhang HX, Jiang SS, Zhang XF, Zhou ZQ, Pan QZ, Chen CL, Zhao JJ, Tang Y, Xia JC, Weng DS
Oncotarget 2015 Oct 27;6(33):34800-17

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 10992-1-AP(CSNK2A1 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The CSNK2A1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CSNK2A1. This antibody recognizes human,mouse,rat antigen. The CSNK2A1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 10992-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human gliomas using 10992-1-AP(CSNK2A1 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue