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Learn19771-1-AP
antibody from Proteintech Group
Targeting: NLRP3
AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, DFNA34, FCAS, FCU, MWS, NALP3, PYPAF1
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [696]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 19771-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19771-1-AP, RRID:AB_10646484
- Product name
- NLRP3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NLRP3 antibody (Cat. #19771-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Salvia miltiorrhiza Bge. processed with porcine cardiac blood alleviates cerebral ischemia reperfusion injury through activating PPARγ/NF-κB pathway via suppressing arachidonic acid metabolism.
Cadmium targeting MLKL-Drp1 axis to trigger mitochondrial oxidative stress contributes to necroinflammation in rat kidney.
Microplastics release from infusion sets during intravenous infusion induces cardiovascular toxicity.
Research based on serine metabolism indicates mesenchymal stem cells alleviate psoriasis by regulating the PSPH-PINK1-Parkin-NLRP3 pathway in HaCaT.
Fibroblast-derived exosomes induce macrophage pyroptosis to mediate orthodontic bone remodeling through the mtDNA/NLRP3 axis.
Viscum coloratum polysaccharide ameliorates hyperuricemic nephropathy by upregulating Nrf2 to inhibit TGF-β1/Smad3 and NLRP3/ASC/Caspase-1 pathways.
Urban particulate matter induces NLRP3/NLRP6 inflammasomes, autophagy, senescence and fibrotic responses by increasing CSF2 signaling in kidney cells.
Flutamide exacerbates hepatic insulin resistance in type 2 diabetic mice through overproduction of ROS and activation of NLRP3 signaling.
Transducin-like enhancer of split 3 protects against lipopolysaccharide-induced inflammation through DEAD-box helicase 5-activating transcription factor 1-protein phosphatase 2 regulatory subunit 5A signaling.
A bioactive protein from Dioscorea polystachya residue alleviates hydrocortisone-induced erectile dysfunction in rats via TXNIP/NLRP3 pathway inhibition.
Human umbilical cord plasma derived exosome inhibit the NLRP3 inflammasome and neuro-apoptosis in traumatic spinal cord injury model.
Sex-Specific Downregulation of CDK5RAP3 Exacerbates ER Stress-Mediated Inflammation and Apoptosis in CCl(4)-Induced Acute Liver Injury.
Free Fatty Acids and Endotoxins Synergically Induce Pyroptosis in Bovine Hepatocytes.
RRx-001 ameliorates astrocyte pyroptosis by regulating LCN2-NLRP3 inflammasome activation in an MPTP-induced parkinson's disease mouse model.
Luteolin alleviates PCOS by inhibiting AR/STAT3/NLRP3-mediated granulosa cell pyroptosis.
Phafin2 modulates the aggregation of NLRP3 on dispersed trans-Golgi network.
Systematic Identification and Functional Validation of CASP10 as a DNA-Damage-Responsive Driver of Endothelial Pyroptosis in Atherosclerosis.
NLRP3-Caspase-1 Axis in Human Adipose Tissue Crown-Like Structures: A Potential Mediator of Inflammation and the Effects of Bariatric Surgery.
Tyrosinase Cross-Linked PEG Hydrogels with DAT and DATT as Artificial Substrates: Design, Structure, and Functions.
Sulfated Pelvetia siliquosa Polysaccharides Attenuate Pyroptosis via NF-κB Pathway Inhibition Against Calcium Oxalate Stone Formation.
Rift Valley fever virus activates multiple cell death pathways in neurons.
Carbon-based nanomaterials induce ovarian dysfunction via NLRP3 inflammasome-mediated pyroptosis in granulosa cells.
Micro/nanoplastics induce thyroid follicular cell pyroptosis to trigger thyrotoxicity by activating NF-κB signaling.
Biosynthesis of Lysosomally Escaped Apoptotic Bodies Inhibits Inflammasome Synthesis in Macrophages.
Perfluorooctane sulfonate induces hepatotoxicity through promoting inflammation, cell death and autophagy in a rat model.
G Protein-Coupled Receptor 30 Attenuates Neuronal Pyroptosis Induced by Subarachnoid Hemorrhage.
Subchronic Chlorpyrifos Exposure Induces Thyroid Follicular Cell Pyroptosis to Exacerbate Thyroid Toxicity by Modulating Nrf2/Keap1/NF-κB Pathway in Male Mice.
TMAO Induces Vascular Endothelial Cells Pyroptosis Through TET2-CYTB-ROS Pathway.
Reduced Thioredoxin Regulates IL-1β Secretion via NLRP3 of IL-1β+ Alveolar Macrophages in COPD.
Gubi Decoction Ameliorates Porous Cartilage Endplate in an Intervertebral Disc Degeneration Model Mouse Through Inhibition of NF-κB Activity and Pyroptosis.
Effect of Acupotomy Modulation of NLRP3/Caspase-1/GSDMD Pathway on Chondrocyte Pyroptosis in Knee Osteoarthritis.
Systemic Lupus Erythematosus Stimulates Chondrocyte Pyroptosis to Aggravate Arthritis via Suppression of NRF-2/KEAP-1 and NF-κB Pathway.
MCC950 Alleviates Experimental Autoimmune Neuritis by Inhibiting NLRP3 Inflammasome Activity and Down-Regulating Interleukin-23/Interleukin-17 Axis Expression.
Glycochenodeoxycholic acid induces the release of IL-1beta from L02 cells via the NLRP3/caspase-1/GSDMD pathway to activate LX2 cells.
Electroacupuncture Regulates Oxidative Stress-Mediated NLRP3/ASC/Caspase-1 Pathway to Inhibit Microglial Activation: Alleviating Neuroinflammation and Depression in IBD.
Electroacupuncture alleviates Parkinson's disease by inhibiting the NLRP3 inflammasome pathway.
Treadmill exercise alleviates Alzheimer's disease pathologies in APP/PS1 mice through modulation of microglial glucose metabolic reprogramming.
Shanling Jiangzhi Tea treats hyperuricemia by inhibition of COMT/MAOA signaling pathway and p53/SERPINE1/NLRP3 signaling pathway.
Trapidil attenuates diabetic cardiomyopathy via GPX3/Nrf2-mediated inhibition of myocardial pyroptosis.
Tetramethylpyrazine alleviates acute pancreatitis inflammation by inhibiting pyroptosis via the NRF2 pathway.
Rhodiola rosea-derived exosome-like nanovesicles inhibit vascular endothelial pyroptosis in the treatment of limb skeletal muscle ischemic injury through the TXNIP/NLNP3 pathway.
Combined effects of quinic acid and isochlorogenic acid B on LPS-induced inflammation and pyroptosis in MAC-T cells and mouse mammary glands.
Cold-Induced RNA-Binding Protein (CIRP) Affects Cerebral Ischemia-Reperfusion Injury Through NF-κB Pathway.
M2 Macrophages-Derived Exosomes Inhibited Podocyte Pyroptosis via lncRNA AFAP1-AS1/EZH2 Axis.
Tangzhiqing Exacerbates Oxidized Low-Density Lipoprotein-Induced Cell Pyroptosis Through Activation of NLRP3 Inflammasome in Human Umbilical Vein Endothelial Cells.
Multi-omics profiling reveals infectious bursal disease virus-induced alterations in gene expression and metabolism in chicken bursa of fabricius.
Curcumin mitigates testicular ischemia-reperfusion injury by suppressing NLRP3-mediated pyroptosis.
Tongxinluo alleviates myocardial ischemia-reperfusion injury by inhibiting the pyroptosis of endothelial cells via the NLRP3/Caspase-1/GSDMD signaling pathway.
A Novel Mechanism of Chlorogenic Acid in Cardioprotection: Blocking NLRP3 Inflammasome via Ca(2+)/CaMKIIα Signaling in Sepsis-Induced Cardiomyopathy.
Melatonin attenuates ischemia-reperfusion-induced acute kidney injury by regulating abnormal autophagy and pyroptosis through SIRT1-mediated p53 deacetylation.
Tetrabromophthalate bis(2-ethylhexyl) ester (TBPH) exposure induces renal inflammation injury by activating MAVS-IRF3 signaling pathway in vitro and in vivo models.
MAO-A inhibition alleviates sepsis-driven lung injury via Nrf2/HO-1 pathway activation and suppression of pyroptosis.
Gestational zearalenone causes fetal intrauterine growth restriction partially through deriving ROS-Drp1 mediated placental PANoptosis.
(Z)-Ligustilide alleviates intervertebral disc degeneration by suppressing nucleus pulposus cell pyroptosis via Atg5/NLRP3 axis.
Canagliflozin Attenuates Podocyte Inflammatory Injury through Suppressing the TXNIP/NLRP3 Signaling Pathway in Diabetic Kidney Disease Mice.
Baicalein Reduces Pyroptosis of Acinar Cells in Hyperlipidemic Acute Pancreatitis by Inhibiting M1 Polarization of Macrophages via the HMGB1/TLR4/NLRP3 Pathway.
Astragaloside IV-PESV facilitates pyroptosis by enhancing palmitoylation of GSDMD protein mediated by ZDHHC1.
Transcriptome profiling reveals a peculiarity of host immune responses to PA-X protein of H9N2 influenza A virus.
Indole-3 propionate inhibits NF-κB/NLRP3-mediated osteoclastogenesis and improves bone quality in high-fat-diet induced obese mice.
CTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway.
Macrophage NLRP3 activation and IL-1β release drive osimertinib-induced antitumor immunity.
TREM-1 Promotes Microglial Pyroptosis and Mitochondrial Fission in Intracerebral Hemorrhage via the PI3K/AKT Pathway.
Bisphenol S as an emerging osteotoxicant: Mechanistic insights from osteoblasts and zebrafish models.
The effect of puerarin on the NLRP3 Inflammasome pathway and MMP-9 in aortic dissection of ApoE(-/-) mice.
NEK7 mediates ESRD-associated endothelial injury by activating the NLRP3 inflammasome.
Monoclonal antibody SZ168 targeting Podoplanin alleviates neuroinflammation by suppressing microglial Pyroptosis in cerebral Hemorrhage.
PACAP inhibits high fat-induced NLRP3 inflammasome-mediated pyroptosis in vascular endothelial cells by regulating the SIRT1/ROS pathway.
Targeting STING alleviates pyroptosis of bladder epithelial cells and ameliorates bladder fibrosis in neurogenic bladder.
Activation of IRF2 signaling networks facilitates podocyte pyroptosis in lupus nephritis.
Traditional wisdom meets modern science: The protective role of sanhuang shu'ai decoction in ulcerative colitis models.
Persistent Activation of Monocytes/Macrophages and Cell Senescence in SIV-Infected Macaques on ART.
Pulsed electromagnetic fields inhibit atherosclerosis by regulating pyroptosis through membrane tension-mediated mechanosensitive channels.
Non-anticoagulant heparin alleviates myocardial ischemia-reperfusion injury through inhibiting GSDMD-mediated cardiomyocyte pyroptosis via the HMGB1/RAGE pathway.
Repurposing of FDA-approved drugs by targeting SIRT2 to alleviate inflammatory response and kidney injury.
Calycosin Protects Against Chronic Prostatitis via Regulating Cellular Pyroptosis.
Grafting of syringic acid onto fucoidan: Enhanced functional properties and therapeutic potential in histamine-induced liver injury.
IL-33 facilitates endoplasmic reticulum stress and pyroptosis in LPS-stimulated ARDS model in vitro.
Deoxynivalenol-induced pyroptosis and autophagy inhibition collectively promote inflammatory injury in the glandular stomach of chicken embryos.
Human umbilical cord mesenchymal stem cell-derived exosomes repair IBD by activating the SIRT1-FXR pathway in macrophages.
Aryl Hydrocarbon Receptor-Dependent miRNA-382-5p Mediates the Classical Pyroptosis Induced by Foodborne Benzo(a)pyrene through Targeting IκB in Liver.
Inhibition of NLRP3 Inflammasome Alleviates Postoperative Cognitive Impairment by Suppressing the HMGB-1/TLR4/NF-κB Pathway.
Icariin alleviates cardiomyocyte pyroptosis through AMPK-NLRP3 pathway to ameliorates diabetic cardiomyopathy.
Thioredoxin-1 inhibits NLRP3-mediated pyroptosis by regulating TXNIP in models of Alzheimer's disease.
p16INK4a Deletion Alleviated Obesity-Associated Kidney Fibrosis by Regulating Metabolic Reprogramming and the Inflammasome Pathway.
Aerobic Exercise Affected Lymphocyte Apoptosis by Modulating ROS Release and NLRP3 Inflammasome Activation.
Exploring vestibulocerebellum-vestibular nuclei-spinal trigeminal nucleus causals communication and TRPV2 ion channel in a mouse model of vestibular migraine.
Sinomenine alleviates neuroinflammation in chronic cerebral hypoperfusion by promoting M2 microglial polarization and inhibiting neuronal pyroptosis via exosomal miRNA-223-3p.
Viral expression of NE/PPE enhances anti-colorectal cancer efficacy of oncolytic adenovirus by promoting TAM M1 polarization to reverse insufficient effector memory/effector CD8(+) T cell infiltration.
Decoding CKD-induced muscle atrophy through the critical role of lncRNA GAS5 and pyroptosis.
Blocking GATA6 Alleviates Pyroptosis and Inhibits Abdominal Wall Endometriosis Lesion Growth Through Inactivating the PI3K/AKT Pathway.
Leveraging the interconnected unfolded protein response and NLRP3 inflammasome pathways to reactivate Epstein-Barr virus in diffuse large B-cell lymphomas.
Drug-free hyaluronic acid-microneedle with unexpected inhibition activity on benzalkonium chloride-induced corneal inflammation and stromal scarring.
MicroRNA-9-3p inhibits endothelial pyroptosis in atherosclerosis by targeting the PTEN/AKT axis.
Photobiomodulation regulates inflammation and autophagy in spinal cord injury through NLRP3/Caspase-1/IL-1β pathway by targeting TLR2.
LncRNA MIR503HG regulates NETs-mediated NLRP3 inflammasome activation and NSCLC metastasis by enhancing the ubiquitination of C/EBPβ.
Pretreatment with Citrus reticulata 'Chachi' Polysaccharide Alleviates Alcohol-Induced Gastric Ulcer by Inhibiting NLRP3/ASC/Caspase-1 and Nrf2/HO-1 Signaling Pathways.
The non-structural protein of SFTSV activates NLRP1 and CARD8 inflammasome through disrupting the DPP9-mediated ternary complex.
Mechanism of hydroxychloroquine in the treatment of obstetric antiphospholipid syndrome by inhibiting NETs-induced trophoblast pyroptosis.
Ginsenoside Rg3 alleviates brain damage caused by chlorpyrifos exposure by targeting and regulating the microbial-gut-brain axis.
Antler base (Cervus nippon Temminck) peptides modulate the NLRP3 inflammatory pyroptosis and Nrf2/HO-1/NQO1 signaling pathways to ameliorate osteoarthritis: a structural and mechanistic study.
Cornus officinalis loganin attenuates acute lung injury in mice via regulating the PI3K/AKT/NLRP3 axis.
Differences in macrophage pyroptosis and polarization induced by nano-/micro-calcium oxalate crystals.
Comparison of the effects of Liraglutide, Tirzepatide, and Retatrutide on diabetic kidney disease in db/db mice.
Highly BBB-permeable nanomedicine reverses neuroapoptosis and neuroinflammation to treat Alzheimer's disease.
Tanreqing Injection Inhibits Activation of NLRP3 Inflammasome in Macrophages Infected with Influenza A Virus by Promoting Mitophagy.
Xylo-oligosaccharides enhance intestinal and thymic immunity by modulating pyroptosis, gut microbiota, and Th17/Treg immune response in lipopolysaccharide-challenged piglets.
Neutrophil extracellular traps promote the activation of the NLRP3 inflammasome and PBMCs pyroptosis via the ROS-dependent signaling pathway in Kawasaki disease.
Mechanism of S100A9-mediated astrocyte activation via TLR4/NF-κB in Parkinson's disease.
Oridonin attenuates diabetic retinopathy progression by suppressing NLRP3 inflammasome pathway.
Disrupted mitochondrial morphology and function exacerbate inflammation in elderly-onset ulcerative colitis.
Knockdown of Leucine-rich alpha-2-glycoprotein 1 alleviates renal ischemia-reperfusion injury by inhibiting NOX4-mediated apoptosis, inflammation, and oxidative stress.
Functionalized Nanozyme Microcapsules Targeting Deafness Prevention via Mitochondrial Homeostasis Remodeling.
Influence of the ERK/CHGB pathway in breast cancer progression under chronic stress.
TRIM44 alleviates renal ischemia-reperfusion injury by inhibiting pyroptosis through the NLRP3 pathway.
Porphyromonas gingivalis and Its Outer Membrane Vesicles Induce Neuroinflammation in Mice Through Distinct Mechanisms.
Structural Characterization and Anti-Gouty Nephropathy Potential of Polysaccharides from Atractylodes chinensis.
Semen extender triggers a mild physiological inflammatory response in the uterus without disrupting sperm-uterine immune crosstalk in vitro in cattle.
Jingui Shenqi Wan alleviates bone loss induced by primary osteoporosis by inhibiting osteoblast pyroptosis.
α-Cyperone Alleviates LPS-Induced Pyroptosis in Rat Aortic Endothelial Cells via the PI3K/AKT Signaling Pathway.
The absence of IRG1 exacerbates bone loss in a mouse model of ovariectomy-induced osteoporosis by increasing osteoclastogenesis through the potentiation of NLRP3 inflammasome activation.
Integrated stress response-mediated metabolic reprogramming drives hepatic stellate cell activation and liver fibrosis via the noncanonical EIF3d-ATF4-S100P signaling pathway.
Suvorexant attenuates cognitive impairment associated with circadian rhythm sleep-wake disorders by modulating microglia activation via the BMAL1/NLRP3 pathway.
By inhibiting pyroptosis to reduce neuroinflammation, PEG-bHb may prevent the development of secondary injury after traumatic brain injury.
Cytosolic TOP3α facilitates mitochondrial DNA sensing by cGAS.
Fisetin carbon dots alleviate periodontitis by enhancing mitophagy through regulation of sirtuin 3 SUMOylation.
Activated oligoadenylate synthetase-ribonuclease L pathway promotes endothelial pyroptosis and impairs diabetic wound healing via thioredoxin-interacting protein m(6)A methylation.
Integrating Network Pharmacology, Molecular Docking, and Experimental Validation: Andrographolide Attenuates Acute Liver Injury via the NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis Pathway.
CD36-mediated fatty acid metabolic reprogramming activates synovial fibroblasts and promotes rheumatoid arthritis progression.
PML Is Limiting NLRP3 Inflammasome Activity in Human Endothelial Cells.
miR-23a-5p Alleviates Gouty Inflammation by Targeting Interleukin-17A and Inhibiting NLR Family Pyrin Domain Containing 3 Inflammasome Activation.
Inhibition of BRD4 alleviates pyroptosis induced by testicular ischemia/reperfusion injury through the NLRP3 pathway.
Gegen Qinlian Decoction improves Alzheimer's disease through TLR4/NF-κB/NLRP3 pathway.
Xuebijing inhibits alveolar macrophage M1 polarization by regulating ROS-mediated NLRP3 inflammasome signaling.
Inhibiting NLRP3 Inflammasome Activation to Alleviate Retinal Inflammation and Protect the Optic Nerve of OPTN(E50K)Mice.
Activation of pyroptosis impairs basal cell differentiation in the nasal epithelium in chronic rhinosinusitis with nasal polyps.
P2X7 receptor is essential for ST36-attenuated cardiac fibrosis upon beta-adrenergic insult.
Spatiotemporal Immunomodulation of Macrophages via NLRP3/IL-1β Pathway by Core-Shell Microneedles to Promote Healing of Biofilm-Infected Diabetic Ulcers.
Cilostazol attenuates vascular inflammation via the regulation of TICAM1/IRF3 signaling pathway.
Carbon Monoxide Alleviates Cardiomyocyte Pyroptosis in Diabetic Cardiomyopathy by Downregulating the IL-33/ST2L Axis.
Whey protein hydrolysate alleviated acetaminophen-induced hepatocyte pyroptosis by activating mitophagy.
HIIT and MICT mitigate endothelial dysfunction in early atherosclerotic mice via PCSK9 inhibition.
MiR-153 is Involved in Testicular Ischemia/Reperfusion Injury by Directly Targeting FOXO3 and Regulating Spermatogonia Pyroptosis.
Schistosoma mansoni soluble egg antigen suppresses colorectal cancer growth in vitro and in vivo.
WTAP Promotes Atherosclerosis by Inducing Macrophage Pyroptosis and M1 Polarization through Upregulating NLRP3.
PCSK9 Targeted Autophagosome-Tethering Compounds: Design, Synthesis, and Antiatherosclerosis Evaluation.
Formononetin ameliorates depression-like behaviors through rebalancing microglia M1/M2 polarization and inhibiting NLRP3 inflammasome: involvement of activating PPARα-mediated autophagy.
E3 ubiquitin ligase CHIP alleviates H/R-induced myocardial injury by inhibiting pyroptosis.
Card9 deficiency exacerbates vulvovaginal candidiasis by impairing the IL-17 production and vaginal epithelial barrier.
VEGF secreted by human dental pulp stem cell promotes spinal cord injury repair by inhibiting microglial pyroptosis through the PI3K/AKT pathway.
Xuebijing improves inflammation and pyroptosis of acute lung injury by up-regulating miR-181d-5p-mediated SPP1 inactivation.
25-hydroxycholesterol aggravates oxygen-glucose deprivation/reoxygenation-induced pyroptosis through promoting activation of NLRP3 inflammasome in H9C2 cardiomyocytes.
M2 Macrophage-Derived Small Extracellular Vesicles Ameliorate Pyroptosis and Intervertebral Disc Degeneration.
Therapeutic potential of HUC-MSC-exos primed with IFN-γ against LPS-induced acute lung injury.
Cryptotanshinone Inhibits Bladder Cancer Cell Malignant Progression in a Lipopolysaccharide-Induced Inflammatory Microenvironment through NLRP3 Inhibition.
Alkali burn injury model of meibomian gland dysfunction in mice.
Arctiin Alleviates Atopic Dermatitis Against Inflammation and Pyroptosis Through Suppressing TLR4/MyD88/NF-κB and NLRP3/Caspase-1/GSDMD Signaling Pathways.
The Onset of Systemic Lupus Erythematosus Triggers Nucleus Pulposus Cell Pyroptosis to Exacerbate Intervertebral Disc Degeneration.
The AGEs/RAGE Signaling Pathway Regulates NLRP3-Mediated Neuronal Pyroptosis After MCAO Injury in Lepr(-/-) Obese Rats.
Identification and Validation of a Necroptosis-Related Prognostic Model in Tumor Recurrence and Tumor Immune Microenvironment in Breast Cancer Management.
Lactobacillus Plantarum Promotes Wound Healing by Inhibiting the NLRP3 Inflammasome and Pyroptosis Activation in Diabetic Foot Wounds.
"Dictionary of immune responses" reveals the critical role of monocytes and the core target IRF7 in intervertebral disc degeneration.
Spermidine attenuates chondrocyte inflammation and cellular pyroptosis through the AhR/NF-κB axis and the NLRP3/caspase-1/GSDMD pathway.
KAE ameliorates LPS-mediated acute lung injury by inhibiting PANoptosis through the intracellular DNA-cGAS-STING axis.
(Pro)renin receptor aggravates myocardial pyroptosis in diabetic cardiomyopathy through AMPK-NLRP3 pathway.
TAK1 inhibition mitigates intracerebral hemorrhage-induced brain injury through reduction of oxidative stress and neuronal pyroptosis via the NRF2 signaling pathway.
Effect of Dl-3-n-Butylphthalide on olfaction in rotenone-induced Parkinson's rats.
Dexmedetomidine improves mitophagy and pyroptosis through the ALKBH5/FUNDC1 axis during epidural-related maternal fever.
The suppressive role of NLRP6 in host defense against Streptococcus suis infection.
Dipsacoside B ameliorates cognitive impairment in sepsis-associated encephalopathy by reducing Th17 cell infiltration and neuroinflammation.
Pseudorabies Virus UL4 protein promotes the ASC-dependent inflammasome activation and pyroptosis to exacerbate inflammation.
Osteoclast-derived exosomes influence osteoblast differentiation in osteoporosis progression via the lncRNA AW011738/ miR-24-2-5p/ TREM1 axis.
Punicalagin Inhibits African Swine Fever Virus Replication by Targeting Early Viral Stages and Modulating Inflammatory Pathways.
Helicobacter pylori CagA mediated mitophagy to attenuate the NLRP3 inflammasome activation and enhance the survival of infected cells.
Trim31 deficiency exacerbates airway inflammation in asthma by enhancing the activation of the NLRP3 inflammasome.
WTAP promotes fibroblast-like synoviocyte pyroptosis in Rheumatoid arthritis by upregulating N6-methyladenosine modification of NLRP3.
Toll-Like Receptor 9 Aggravates Pulmonary Fibrosis by Promoting NLRP3-Mediated Pyroptosis of Alveolar Epithelial Cells.
Ferulic Acid Interferes with Radioactive Intestinal Injury Through the DJ-1-Nrf2 and Sirt1-NF-κB-NLRP3 Pathways.
Hepatocyte-specific NR5A2 deficiency induces pyroptosis and exacerbates non-alcoholic steatohepatitis by downregulating ALDH1B1 expression.
LINC00365 promotes miR-221-5p to inhibit pyroptosis via Dicer in colorectal cancer.
Glutamine metabolism modulates microglial NLRP3 inflammasome activity through mitophagy in Alzheimer's disease.
Role for NLRP3 inflammasome-mediated, Caspase1-dependent response in glaucomatous trabecular meshwork cell death and regulation of aqueous humor outflow.
Ulinastatin modulates NLRP3 inflammasome pathway in PTZ-induced epileptic mice: A potential mechanistic insight.
miRNA-193a-mediated WT1 suppression triggers podocyte injury through activation of the EZH2/β-catenin/NLRP3 pathway in children with diabetic nephropathy.
Inhibition of BCAT1 expression improves recurrent miscarriage by regulating cellular dysfunction and inflammation of trophoblasts.
Polystyrene Microplastics Induce Injury to the Vascular Endothelial Through NLRP3-Mediated Pyroptosis.
Multifunctional Copper-Phenolic Nanopills Achieve Comprehensive Polyamines Depletion to Provoke Enhanced Pyroptosis and Cuproptosis for Cancer Immunotherapy.
Lycium barbarum polysaccharides (LBP) suppresses hypoxia/reoxygenation (H/R)-induced rat H9C2 cardiomyocytes pyroptosis via Nrf2/HO-1 signaling pathway.
HBSP inhibits tubular cell pyroptosis and apoptosis, promotes macrophage M2 polarization, and protects LPS-induced acute kidney injury.
Targeting GPR39 in structure-based drug discovery reduces Ang II-induced hypertension.
GEFT inhibits the GSDM-mediated proptosis signalling pathway, promoting the progression and drug resistance of rhabdomyosarcoma.
Ginsenoside Rg1 Alleviates Blood-Milk Barrier Disruption in Subclinical Bovine Mastitis by Regulating Oxidative Stress-Induced Excessive Autophagy.
DsbA-L activates TGF-β1/SMAD3 signaling and M2 macrophage polarization by stimulating AKT1 and NLRP3 to promote pulmonary fibrosis.
Paeoniflorin Inhibits the Activation of Microglia and Alleviates Depressive Behavior by Regulating SIRT1-NF-kB-NLRP3/Pyroptosis Pathway.
Microplastics Exposure Aggravates Synovitis and Pyroptosis in SLE by Activating NF-κB and NRF2/KEAP1 Signaling.
Insufficient FUNDC1-dependent mitophagy due to early environmental cadmium exposure triggers mitochondrial redox imbalance to aggravate diet-induced lipotoxicity.
Inhibition of the FOXO1-ROCK1 axis mitigates cardiomyocyte injury under chronic hypoxia in Tetralogy of Fallot by maintaining mitochondrial quality control.
Administration of USP7 inhibitor p22077 alleviates Angiotensin II (Ang II)-induced atrial fibrillation in Mice.
Ampelopsin facilitates diabetic wound healing and keratinocyte cell progression by inhibiting the NLRP3 inflammasome pathway in macrophages.
Supercritical CO(2) fluid extract from Stellariae Radix ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis by inhibit M1 macrophages polarization via AMPK activation.
Nattokinase attenuates endothelial inflammation through the activation of SRF and THBS1.
Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis.
Chinese medicinal formula Fu Xin decoction against chronic heart failure by inhibiting the NLRP3/caspase-1/GSDMD pyroptotic pathway.
Platelet-rich plasma-derived extracellular vesicles inhibit NF-κB/NLRP3 pathway-mediated pyroptosis in intervertebral disc degeneration via the MALAT1/microRNA-217/SIRT1 axis.
ZAP facilitates NLRP3 inflammasome activation via promoting the oligomerization of NLRP3.
A potential virulence factor: Brucella flagellin FliK does not affect the main biological properties but inhibits the inflammatory response in RAW264.7 cells.
The role of FGF-21 in promoting diabetic wound healing by modulating high glucose-induced inflammation.
Therapeutic Potential of Fucoidan in Alleviating Histamine-Induced Liver Injury: Insights from Mice Studies.
MSC-derived exosomal miR-140-3p improves cognitive dysfunction in sepsis-associated encephalopathy by HMGB1 and S-lactoylglutathione metabolism.
Salvianolic acid B attenuates diabetic nephropathy through alleviating ADORA2B, NALP3 in flammasome, and NFκB activity.
Pesticide avermectin-induced hepatotoxicity and growth inhibition in carp: Ameliorative capacity and potential mechanisms of quercetin as a dietary additive.
BRCC36 Deubiquitinates HMGCR to Regulate the Interplay Between Ferroptosis and Pyroptosis.
Exogenous hydrogen sulfide ameliorates diabetes-associated cognitive dysfunction by regulating the nrf-2/HO-1 axis and the NLRP3 inflammasome pathway in diabetic rats.
Rutaecarpine protects podocytes in diabetic kidney disease by targeting VEGFR2/NLRP3-mediated pyroptosis.
VDR and deubiquitination control neuronal oxidative stress and microglial inflammation in Parkinson's disease.
Lactococcus garvieae exerts a critical role in inducing inflammation in dairy mastitis by triggering NLRP3 inflammasome-mediated pyroptosis in MAC-T cells.
Atrazine exposure promotes cardiomyocyte pyroptosis to exacerbate cardiotoxicity by activating NF-κB pathway.
Cutting Edge: Cytosolic Receptor AIM2 Is Induced by Peroxisome Proliferator-activated Receptor γ following Mycobacterium tuberculosis Infection of Human Macrophages but Does Not Contribute to IL-1β Release.
Interleukin-33/ST2 axis involvement in atrial remodeling and arrhythmogenesis.
Paeoniflorin alleviates depression by inhibiting the activation of NLRP3 inflammasome via promoting mitochondrial autophagy.
Bile acids induce liver fibrosis through the NLRP3 inflammasome pathway and the mechanism of FXR inhibition of NLRP3 activation.
Bile acid metabolism is altered in learning and memory impairment induced by chronic lead exposure.
Revealing the Mechanism of NLRP3 Inflammatory Pathway Activation through K(+) Efflux Induced by PLO via Signal Point Mutations.
Augmented microglial endoplasmic reticulum-mitochondria contacts mediate depression-like behavior in mice induced by chronic social defeat stress.
MINK1 deficiency stimulates nucleus pulposus cell pyroptosis and exacerbates intervertebral disc degeneration.
Trim27 aggravates airway inflammation and oxidative stress in asthmatic mice via potentiating the NLRP3 inflammasome.
Butyrate attenuates sympathetic activation in rats with chronic heart failure by inhibiting microglial inflammation in the paraventricular nucleus.
miR-485-3p targets SIRT1 in vascular smooth muscle cells mediating the occurrence of aortic dissection.
Long Non-coding RNA ZFAS1 Regulates Fibrosis and Scortosis in the Cell Model of Diabetic Nephropathy Through miR-525-5p/SGK1 Axis.
Modified Danzhi XiaoyaoSan inhibits neuroinflammation via regulating TRIM31/NLRP3 inflammasome in the treatment of CUMS depression.
Adiponectin inhibits ROS/NLRP3 inflammatory pathway through FOXO3A to ameliorate oral submucosal fibrosis.
4-Octyl itaconate inhibits inflammation via the NLRP3 pathway in neuromyelitis optica spectrum disorders.
Glycolytic enzyme PGK1 promotes M1 macrophage polarization and induces pyroptosis of acute lung injury via regulation of NLRP3.
Baicalin and probenecid protect against Glaesserella parasuis challenge in a piglet model.
The downregulation of SCGN induced by lipotoxicity promotes NLRP3-mediated β-cell pyroptosis.
Acceleration of bone repairation by BMSCs overexpressing NGF combined with NSA and allograft bone scaffolds.
Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication.
ZIF-8-based Nanoparticles for Inflammation Treatment and Oxidative Stress Reduction in Periodontitis.
NADase CD38 is a key determinant of ovarian aging.
Empagliflozin reduces endoplasmic reticulum stress associated TXNIP/NLRP3 activation in tunicamycin-stimulated aortic endothelial cells.
GAS6 attenuates sepsis-induced cardiac dysfunction through NLRP3 inflammasome-dependent mechanism.
Extracellular ATP (eATP) inhibits the progression of endometriosis and enhances the immune function of macrophages.
Brassisterol A, a new ergosterol from co-cultivation of fungi attenuates neuroinflammation via targeting NLRP3/caspase-1/GSDMD pathway.
Bacteroides fragilis alleviates necrotizing enterocolitis through restoring bile acid metabolism balance using bile salt hydrolase and inhibiting FXR-NLRP3 signaling pathway.
Weizmannia coagulans BCF-01: a novel gastrogenic probiotic for Helicobacter pylori infection control.
Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress.
Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Ameliorate Aging-Induced BTB Impairment in Porcine Testes by Activating Autophagy and Inhibiting ROS/NLRP3 Inflammasomes via the AMPK/mTOR Signaling Pathway.
Colchicine ameliorates myocardial injury induced by coronary microembolization through suppressing pyroptosis via the AMPK/SIRT1/NLRP3 signaling pathway.
Knockdown of ChREBP ameliorates retinal microvascular endothelial cell injury and angiogenic responses in diabetic retinopathy.
Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.
Carvedilol induces pyroptosis through NLRP3-caspase1-ASC inflammasome by nuclear migration of NF-κB in prostate cancer models.
Endoplasmic reticulum aminopeptidase 2 regulates CD4(+) T cells pyroptosis in rheumatoid arthritis.
Rutin prevents pyroptosis and M1 microglia via Nrf2/Mac-1/caspase-1-mediated inflammasome axis to improve POCD.
Targeted Degradation of PCSK9 In Vivo by Autophagy-Tethering Compounds.
VSIG4 ameliorates intestinal inflammation through inhibiting macrophages NLRP3 inflammasome and pyroptosis.
4-octyl itaconate ameliorates ventilator-induced lung injury.
Investigating the TLR4/TAK1/IRF7 axis in NLRP3-Mediated Pyroptosis in Parkinson's Disease.
Methane-Rich Saline Suppresses ER-Mitochondria Contact and Activation of the NLRP3 Inflammasome by Regulating the PERK Signaling Pathway to Ameliorate Intestinal Ischemia‒Reperfusion Injury.
Serabelisib regulates GSDMD-mediated pyroptosis, apoptosis and migration of hepatoma cells via the PI3K/Akt/E-cadherin signaling pathway.
Sodium-glucose co-transporter 2 inhibitor canagliflozin modulates myocardial metabolism and inflammation in a swine model for chronic myocardial ischemia.
ALOX5 drives the pyroptosis of CD4(+) T cells and tissue inflammation in rheumatoid arthritis.
PPAR γ activation in chondrocytes alleviates glucocorticoid-induced oxidative stress, mitochondrial impairment, and pyroptosis via autophagic flow enhancement.
Baicalin attenuates lipopolysaccharide-induced intestinal inflammatory injury via suppressing PARP1-mediated NF-κB and NLRP3 signalling pathway.
Isofraxidin attenuates dextran sulfate sodium-induced ulcerative colitis through inhibiting pyroptosis by upregulating Nrf2 and reducing reactive oxidative species.
An Amino Acids and Dipeptide Injection Inhibits the TNF-α/HMGB1 Inflammatory Signaling Pathway to Reduce Pyroptosis and M1 Microglial Polarization in POCD Mice: the Gut to the Brain.
Shikonin from lithospermum erythrorhizon induces pyroptosis in trophoblast cells by activating the CTSB-NLRP3 inflammasome.
Mesenchymal stem cell-loaded hydrogel to inhibit inflammatory reaction in surgical brain injury via mitochondria transfer.
Y9, a Gboxin analog, displays anti-tumor effect in non-small cell lung cancer by inducing lysosomal dysfunction and apoptosis.
Jianwei Shoutai Pills alleviates miscarriage by modulating gut microbial production of BAs and NLRP3-inflammasome at the maternal-fetal interface of rats.
Xiaoyaosan against depression through suppressing LPS mediated TLR4/NLRP3 signaling pathway in "microbiota-gut-brain" axis.
Mammary hydroxylated oestrogen activates the NLRP3 inflammasome in tumor-associated macrophages to promote breast cancer progression and metastasis.
Kaempferol improves depression-like behaviors through shifting microglia polarization and suppressing NLRP3 via tilting the balance of PPARγ and STAT1 signaling.
HDAC10 switches NLRP3 modification from acetylation to ubiquitination and attenuates acute inflammatory diseases.
Astragaloside IV attenuates podocyte apoptosis via regulating TXNIP/NLRP3/GSDMD signaling pathway in diabetic nephropathy.
Role of AhR-Hsp90-MDM2-mediated VDR ubiquitination in PM2.5-induced renal toxicity.
Comparison of Endoplasmic Reticulum Stress and Pyroptosis Induced by Pathogenic Calcium Oxalate Monohydrate and Physiologic Calcium Oxalate Dihydrate Crystals in HK-2 Cells: Insights into Kidney Stone Formation.
The molecular mechanisms by which the NLRP3 inflammasome regulates blood-brain barrier permeability following cryptococcal meningitis.
Exosomes from human bone marrow MSCs alleviate PD-1/PD-L1 inhibitor-induced myocardial injury in melanoma mice by regulating macrophage polarization and pyroptosis.
TRPM7 contributes to pyroptosis and its involvement in status epilepticus.
Autocatalytic, Brain Tumor-Targeting Delivery of Bardoxolone Methyl Self-Assembled Nanoparticles for Glioblastoma Treatment.
1,8-cineole ameliorates experimental diabetic angiopathy by inhibiting NLRP3 inflammasome-mediated pyroptosis in HUVECs via SIRT2.
Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling.
Reactive Oxygen Species-Responsive Nanoparticle Delivery of Small Interfering Ribonucleic Acid Targeting Olfactory Receptor 2 for Atherosclerosis Theranostics.
Inhibition of aquaporin-9 ameliorates severe acute pancreatitis and associated lung injury by NLRP3 and Nrf2/HO-1 pathways.
SGK3 deficiency in macrophages suppresses angiotensin II-induced cardiac remodeling via regulating Ndufa13-mediated mitochondrial oxidative stress.
Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead.
STAT4-Mediated Klotho Up-Regulation Contributes to the Brain Ischemic Tolerance by Cerebral Ischemic Preconditioning via Inhibiting Neuronal Pyroptosis.
NLRP3 Inflammasome-dependent Pathway is Involved in the Pathogenesis of Polycystic Ovary Syndrome.
M1 polarization of macrophages promotes stress-induced hair loss via interleukin-18 and interleukin-1β.
SARS-CoV-2 virus-like particle variants alpha and delta mimic the native viruses in their differential inflammasome activating potential.
Intestinal metabolite UroB alleviates cerebral ischemia/reperfusion injury by promoting competition between TRIM65 and TXNIP for binding to NLRP3 inflammasome in response to neuroinflammation.
Mycobacterium tuberculosis PE_PGRS38 Enhances Intracellular Survival of Mycobacteria by Inhibiting TLR4/NF-κB-Dependent Inflammation and Apoptosis of the Host.
The prevention effect of pulsed electromagnetic fields treatment on senile osteoporosis in vivo via improving the inflammatory bone microenvironment.
Preliminary investigation into the impact of BPA on osteoblast activity and bone development: In vitro and in vivo models.
LncRNA GAS5 restrains ISO-induced cardiac fibrosis by modulating mir-217 regulation of SIRT1.
Role and significance of SIRT1 in regulating the LPS-activated pyroptosis pathway in children with congenital hydronephrosis.
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Astragaloside IV Attenuates High-Glucose-Induced Impairment in Diabetic Nephropathy by Increasing Klotho Expression via the NF-κB/NLRP3 Axis.
Transcutaneous Electrical Nerve Stimulation (TENS) Alleviates Brain Ischemic Injury by Regulating Neuronal Oxidative Stress, Pyroptosis, and Mitophagy.
Hemoglobin Derived from Subarachnoid Hemorrhage-Induced Pyroptosis of Neural Stem Cells via ROS/NLRP3/GSDMD Pathway.
HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis in a Sepsis Model.
Curcumin Ameliorates Age-Induced Tight Junction Impaired in Porcine Sertoli Cells by Inactivating the NLRP3 Inflammasome through the AMPK/SIRT3/SOD2/mtROS Signaling Pathway.
RBCK1 Overexpression Attenuates Inflammation and Mobility of Derp1-Induced Nasal Mucosal Cells by Downregulating NLRP3.
Transcutaneous electrical acupoint stimulation alleviates cerebral ischemic injury through the TLR4/MyD88/NF-κ B pathway.
Aspirin-triggered Resolvin D1 ameliorates activation of the NLRP3 inflammasome via induction of autophagy in a rat model of neuropathic pain.
The influence of angiopoietin-like protein 3 on macrophages polarization and its effect on the podocyte EMT in diabetic nephropathy.
Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation.
Epigallocatechin gallate alleviates mono-2-ethylhexyl phthalate-induced male germ cell pyroptosis by inhibiting the ROS/mTOR/NLRP3 pathway.
Pseudorabies virus infection activates the NLRP3 and IFI16 inflammasomes to trigger pyroptosis.
Maslinic acid alleviates LPS-induced mice mastitis by inhibiting inflammatory response, maintaining the integrity of the blood-milk barrier and regulating intestinal flora.
NDUFC2 deficiency exacerbates endothelial mesenchymal transformation during ischemia-reperfusion via NLRP3.
MicroRNA miR-223 modulates NLRP3 and Keap1, mitigating lipopolysaccharide-induced inflammation and oxidative stress in bovine mammary epithelial cells and murine mammary glands.
Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme.
Ghrelin inhibits NLRP3 inflammasome activation by upregulating autophagy to improve Alzheimer's disease.
Ampelopsin attenuates Staphylococcus aureus Alpha-Toxin-Induced Lung Injury.
HMGB1 induces macrophage pyroptosis in chronic endometritis.
Systemic pharmacology reveal the mechanism by which the Qiangjin Zhuanggu Qufeng mixture inhibits LPS-induced pyroptosis of rat nucleus pulposus cells.
Down-regulation of OIP5-AS1 inhibits obesity-induced myocardial pyroptosis and miR-22/NLRP3 inflammasome axis.
Deficient chaperone-mediated autophagy facilitates LPS-induced microglial activation via regulation of the p300/NF-κB/NLRP3 pathway.
ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer.
Posttranslational ISGylation of NLRP3 by HERC enzymes facilitates inflammasome activation in models of inflammation.
Role of NLRP3 in the exacerbation of ozone-induced allergic rhinitis.
Downregulation of XBP1s aggravates lipopolysaccharide-induced inflammation by promoting NF-κB and NLRP3 pathways' activation in goat endometrial epithelial cells.
Aluminum exposure induces central nervous system impairment via activating NLRP3-medicated pyroptosis pathway.
Role and anti-inflammatory mechanisms of acupuncture and moxibustion therapy on pain relief through NOX-ROS-NLRP3 pathway in CCI rats models.
AR/PCC herb pair inhibits osteoblast pyroptosis to alleviate diabetes-related osteoporosis by activating Nrf2/Keap1 pathway.
An HPK1 inhibitor enhanced the tumour response to anti-PD-1 immunotherapy in non-Hodgkin's lymphoma.
Selenium Deficiency via the ROS/NLRP3/IL-1β Signaling Pathway Leads to Pyroptosis Injury in Pig Spleen.
Escherichia coli infection mediates pyroptosis via activating p53-p21 pathway-regulated apoptosis and cell cycle arrest in bovine mammary epithelial cells.
Carnosine alleviates cisplatin-induced acute kidney injury by targeting Caspase-1 regulated pyroptosis.
Lipopolysaccharide promotes NLRP3 inflammasome activation by inhibiting TFEB-mediated autophagy in NRK-52E cells.
Inhibition of Caspase-1-mediated pyroptosis promotes osteogenic differentiation, offering a therapeutic target for osteoporosis.
Trans-anethole pretreatment ameliorates hepatic ischemia-reperfusion injury via regulation of soluble epoxide hydrolase.
Melatonin alleviates intrarenal CaOx crystals deposition through inhibiting LPS-induced non-canonical inflammasome-mediated renal tubular epithelial cells pyroptosis.
Pyroptosis of chondrocytes activated by synovial inflammation accelerates TMJ osteoarthritis cartilage degeneration via ROS/NLRP3 signaling.
Mesenchymal stem cell-derived exosomal miR-548x-3p inhibits pyroptosis of vascular endothelial cells through HMGB1 in heat stroke.
Resatorvid alleviates experimental inflammatory TMJOA by restraining chondrocyte pyroptosis and synovial inflammation.
Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer.
Injectable kaempferol-loaded fibrin glue regulates the metabolic balance and inhibits inflammation in intervertebral disc degeneration.
STING contributes to trauma-induced heterotopic ossification through NLRP3-dependent macrophage pyroptosis.
The involvement of DDX3X in compression-induced nucleus pulposus pyroptosis.
MALAT1 participates in the role of platelet-rich plasma exosomes in promoting wound healing of diabetic foot ulcer.
HuNoV Non-Structural Protein P22 Induces Maturation of IL-1β and IL-18 and N-GSDMD-Dependent Pyroptosis through Activating NLRP3 Inflammasome.
β-Hydroxybutyric acid upregulated by Suhuang antitussive capsule ameliorates cough variant asthma through GSK3β/AMPK-Nrf2 signal axis.
Heat-killed Lactobacillus murinus confers neuroprotection against dopamine neuronal loss by targeting NLRP3 inflammasome.
hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration.
Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis.
Long-term exercise preserves pancreatic islet structure and β-cell mass through attenuation of islet inflammation and fibrosis.
Protective effects of baicalin against L-glutamate-induced oxidative damage in HT-22 cells by inhibiting NLRP3 inflammasome activation via Nrf2/HO-1 signaling.
Cytotoxic steroidal glycosides from the rhizomes of Paris polyphylla var. yunnanensis.
TMEM16F may be a new therapeutic target for Alzheimer's disease.
Protective effecs of baicalin magnesium on non-alcoholic steatohepatitis rats are based on inhibiting NLRP3/Caspase-1/IL-1β signaling pathway.
Emodin alleviates testicular ischemia-reperfusion injury through the inhibition of NLRP3-mediated pyroptosis.
Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma.
Salmonella typhimurium exacerbates injuries but resolves fibrosis in liver and spleen during Schistosoma mansoni infection.
LOXL1-AS1 Aggravates Myocardial Ischemia/Reperfusion Injury Through the miR-761/PTEN Axis.
Trehalose prevents glyphosate-induced hepatic steatosis in roosters by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation.
Serum amyloid A and interleukin -1β facilitate LDL transcytosis across endothelial cells and atherosclerosis via NF-κB/caveolin-1/cavin-1 pathway.
Du Huo Ji Sheng Tang inhibits Notch1 signaling and subsequent NLRP3 activation to alleviate cartilage degradation in KOA mice.
Fucoxanthin alleviated atherosclerosis by regulating PI3K/AKT and TLR4/NFκB mediated pyroptosis in endothelial cells.
Evidence on the therapeutic role of thiolutin in imiquimod-induced psoriasis-like skin inflammation in mice.
Acid-sensing ion channel 1a exacerbates renal ischemia-reperfusion injury through the NF-κB/NLRP3 inflammasome pathway.
An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation.
Fibrin glue delivery system containing rhein ameliorates intervertebral disc degeneration by anti-inflammatory efficacy.
The protective effects of sophocarpine on sepsis-induced cardiomyopathy.
circACTA2 inhibits NLRP3 inflammasome-mediated inflammation via interacting with NF-κB in vascular smooth muscle cells.
Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia.
Forsythiaside A Alleviates Lipopolysaccharide-Induced Acute Liver Injury through Inhibiting Endoplasmic Reticulum Stress and NLRP3 Inflammasome Activation.
Down-regulated Smyd1 participated in the inhibition of myoblast differentiation induced by cigarette smoke extract.
Multi-omics analysis reveals BDE47 induces depression-like behaviors in mice by interfering with the 2-arachidonoyl glycerol-associated microbiota-gut-brain axis.
Identification of PIK3CG as a hub in septic myocardial injury using network pharmacology and weighted gene co-expression network analysis.
The Correlation between Increased Expressions of NLRP3 Inflammasome Components in Peripheral Blood Mono-Nuclear Cells and Plaque Vulnerability in Human Carotid Atherosclerosis.
Salidroside protects pancreatic β-cells against pyroptosis by regulating the NLRP3/GSDMD pathway in diabetic conditions.
Involvement of Galectin-3 in neurocognitive impairment in obstructive sleep apnea via regulating inflammation and oxidative stress through NLRP3.
Epigenetic control of LncRNA NEAT1 enables cardiac fibroblast pyroptosis and cardiac fibrosis.
NAMPT encapsulated by extracellular vesicles from young adipose-derived mesenchymal stem cells treated tendinopathy in a "One-Stone-Two-Birds" manner.
Proteogenomics of diffuse gliomas reveal molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms.
Pmorf0222, a Virulence Factor in Pasteurella multocida, Activates Nuclear Factor Kappa B and Mitogen-Activated Protein Kinase via Toll-Like Receptor 1/2.
Jatrorrhizine Suppresses Murine-Norovirus-Triggered N-GSDMD-Dependent Pyroptosis in RAW264.7 Macrophages.
The combined effect of deoxynivalenol and Fumonisin B(1) on small intestinal inflammation mediated by pyroptosis in vivo and in vitro.
Cadmium exposure promotes thyroid pyroptosis and endocrine dysfunction by inhibiting Nrf2/Keap1 signaling.
Aluminum induces neuroinflammation via P2X7 receptor activating NLRP3 inflammasome pathway.
VX-765 attenuates silica-induced lung inflammatory injury and fibrosis by modulating alveolar macrophages pyroptosis in mice.
Taurine alleviates ochratoxin A-induced pyroptosis in PK-15 cells by inhibiting oxidative stress.
Exercise induced meteorin-like protects chondrocytes against inflammation and pyroptosis in osteoarthritis by inhibiting PI3K/Akt/NF-κB and NLRP3/caspase-1/GSDMD signaling.
Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis.
Ginsenoside Rg3 Ameliorates DSS-Induced Colitis by Inhibiting NLRP3 Inflammasome Activation and Regulating Microbial Homeostasis.
Notopterol Ameliorates Hyperuricemia-Induced Cardiac Dysfunction in Mice.
Hydrogen Sulfide Inhibited Sympathetic Activation in D-Galactose-Induced Aging Rats by Upregulating Klotho and Inhibiting Inflammation in the Paraventricular Nucleus.
HBx-induced PLA(2)R overexpression mediates podocyte pyroptosis through the ROS-NLRP3 signaling pathway.
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Tryptophan alleviates lipopolysaccharide-induced liver injury and inflammation by modulating necroptosis and pyroptosis signaling pathways in piglets.
Hypoxia-inducible factor 1α activates the NLRP3 inflammasome to regulate epithelial differentiation in chronic rhinosinusitis.
Berberine ameliorates renal interstitial inflammation and fibrosis in mice with unilateral ureteral obstruction.
Puerarin-Tanshinone IIA Suppresses atherosclerosis inflammatory plaque via targeting succinate/HIF-1α/IL-1β axis.
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression.
Paeoniflorin recued hepatotoxicity under zinc oxide nanoparticles exposure via regulation on gut-liver axis and reversal of pyroptosis.
Ginsenoside Rg1 Alleviates Lipopolysaccharide-Induced Fibrosis of Endometrial Epithelial Cells in Dairy Cows by Inhibiting Reactive Oxygen Species-Activated NLRP3.
Ginsenoside compound K alleviates osteoarthritis by inhibiting NLRP3‑mediated pyroptosis.
Hyperuricemia promotes the progression of atherosclerosis by activating endothelial cell pyroptosis via the ROS/NLRP3 pathway.
Effects of sodium metabisulfite on pyroptosis, mitophagy and degranulation in mast cells.
MiR-195-5p is involved in testicular ischemia/reperfusion injury by directly targeting PELP1 and regulating spermatogonia pyroptosis.
Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis.
NLRP3 mediates the neuroprotective effects of SVHRSP derived from scorpion venom in rotenone-induced experimental Parkinson's disease model.
SARS-CoV-2 E protein-induced THP-1 pyroptosis is reversed by Ruscogenin.
PTTG1 alleviates acute alcoholic liver injury by inhibiting endoplasmic reticulum stress-induced hepatocyte pyroptosis.
Bufalin alleviates acute kidney injury by regulating NLRP3 inflammasome-mediated pyroptosis.
PRRSV infection activates NLRP3 inflammasome through inducing cytosolic mitochondrial DNA stress.
Bullatine A has an antidepressant effect in chronic social defeat stress mice; Implication of microglial inflammasome.
Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3β/Nrf2 signaling-mediated ferroptosis in vivo and in vitro.
Ginsenoside Rb1 alleviated concanavalin A-induced hepatocyte pyroptosis by activating mitophagy.
Pyroptosis-Mediated Damage Mechanism by Deoxynivalenol in Porcine Small Intestinal Epithelial Cells.
Prevention of the Pro-Aggressive Effects of Ethanol-Intoxicated Mice by Schisandrin B.
3,4-benzopyrene aggravates myocardial ischemia-reperfusion injury-induced pyroptosis through inhibition of autophagy-dependent NLRP3 degradation.
Cardiac-specific knockdown of Bhlhe40 attenuates angiotensin II (Ang II)-Induced atrial fibrillation in mice.
Lactobacillus casei SYF-08 Protects Against Pb-Induced Injury in Young Mice by Regulating Bile Acid Metabolism and Increasing Pb Excretion.
Long noncoding RNA maternally expressed gene 3 improves trophoblast dysfunction and inflammation in preeclampsia through the Wnt/β-Catenin/nod-like receptor pyrin domain-containing 3 axis.
Cadmium mediates pyroptosis of human dermal lymphatic endothelial cells in a NLRP3 inflammasome-dependent manner.
lncRNA IGF2-AS Regulates Nucleotide Metabolism by Mediating HMGA1 to Promote Pyroptosis of Endothelial Progenitor Cells in Sepsis Patients.
Betaine Inhibits NLRP3 Inflammasome Hyperactivation and Regulates Microglial M1/M2 Phenotypic Differentiation, Thereby Attenuating Lipopolysaccharide-Induced Depression-Like Behavior.
Yanghe Pingchuan Granules Alleviate Airway Inflammation in Bronchial Asthma and Inhibit Pyroptosis by Blocking the TLR4/NF-κB/NRLP3 Signaling Pathway.
Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis.
Calycosin Alleviates Doxorubicin-Induced Cardiotoxicity and Pyroptosis by Inhibiting NLRP3 Inflammasome Activation.
Lignans from Mosla scabra Ameliorated Influenza A Virus-Induced Pneumonia via Inhibiting Macrophage Activation.
Yishen Capsule Alleviated Symptoms of Diabetic Nephropathy via NOD-like Receptor Signaling Pathway.
Mfn2 is responsible for inhibition of the RIG-I/IRF7 pathway and activation of NLRP3 inflammasome in Seneca Valley virus-infected PK-15 cells to promote viral replication.
Integrated pyroptosis measurement and metabolomics to elucidate the effect and mechanism of tangzhiqing on atherosclerosis.
NLRP3 downregulation enhances engraftment and functionality of adipose-derived stem cells to alleviate erectile dysfunction in diabetic rats.
Cyclovirobuxine D Ameliorates Experimental Diabetic Cardiomyopathy by Inhibiting Cardiomyocyte Pyroptosis via NLRP3 in vivo and in vitro.
Protective Effect of Danshen Zexie Decoction Against Non-Alcoholic Fatty Liver Disease Through Inhibition of ROS/NLRP3/IL-1β Pathway by Nrf2 Signaling Activation.
Neutrophil Extracellular Traps (NETs) Promote Non-Small Cell Lung Cancer Metastasis by Suppressing lncRNA MIR503HG to Activate the NF-κB/NLRP3 Inflammasome Pathway.
Platelet derived growth factor promotes the recovery of traumatic brain injury by inhibiting endoplasmic reticulum stress and autophagy-mediated pyroptosis.
Succinate/IL-1β Signaling Axis Promotes the Inflammatory Progression of Endothelial and Exacerbates Atherosclerosis.
Nrf2 Signaling Pathway Mediates the Protective Effects of Daphnetin Against D-Galactose Induced-Premature Ovarian Failure.
Metformin Inhibits NLR Family Pyrin Domain Containing 3 (NLRP)-Relevant Neuroinflammation via an Adenosine-5'-Monophosphate-Activated Protein Kinase (AMPK)-Dependent Pathway to Alleviate Early Brain Injury After Subarachnoid Hemorrhage in Mice.
Inflammatory-Dependent Bidirectional Effect of Bile Acids on NLRP3 Inflammasome and Its Role in Ameliorating CPT-11-Induced Colitis.
Pyroptosis relates to tumor microenvironment remodeling and prognosis: A pan-cancer perspective.
Corilagin alleviates intestinal ischemia/reperfusion-induced intestinal and lung injury in mice via inhibiting NLRP3 inflammasome activation and pyroptosis.
Administration of USP7 inhibitor P22077 inhibited cardiac hypertrophy and remodeling in Ang II-induced hypertensive mice.
Identification of pyroptosis-related lncRNA signature and AC005253.1 as a pyroptosis-related oncogene in prostate cancer.
PINK1-Dependent Mitophagy Reduced Endothelial Hyperpermeability and Cell Migration Capacity Under Simulated Microgravity.
Mechanical Stimulation Protects Against Chondrocyte Pyroptosis Through Irisin-Induced Suppression of PI3K/Akt/NF-κB Signal Pathway in Osteoarthritis.
Biomimetic Metal-Organic Framework Nanoparticles for Synergistic Combining of SDT-Chemotherapy Induce Pyroptosis in Gastric Cancer.
Mechanism of nonylphenol induced gastric inflammation through NF-κB/NLRP3 signaling pathway.
Salvianolic Acid B Alleviates Myocardial Ischemia Injury by Suppressing NLRP3 Inflammasome Activation via SIRT1-AMPK-PGC-1α Signaling Pathway.
MicroRNA-223 downregulation promotes HBx-induced podocyte pyroptosis by targeting the NLRP3 inflammasome.
Aqueous extract of Scrophularia ningpoensis improves insulin sensitivity through AMPK-mediated inhibition of the NLRP3 inflammasome.
Lactobacillus rhamnosus GR-1 attenuates foodborne Bacillus cereus-induced NLRP3 inflammasome activity in bovine mammary epithelial cells by protecting intercellular tight junctions.
Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway.
The role of proteoglycan form of DMP1 in cranial repair.
Itaconate Attenuates Neuroinflammation and Exerts Dopamine Neuroprotection in Parkinson's Disease through Inhibiting NLRP3 Inflammasome.
Anti-inflammatory potential of stevia residue extract against uric acid-associated renal injury in mice.
ALPK1 Accelerates the Pathogenesis of Osteoarthritis by Activating NLRP3 Signaling.
Substance P promotes the progression of bronchial asthma through activating the PI3K/AKT/NF-κB pathway mediated cellular inflammation and pyroptotic cell death in bronchial epithelial cells.
VCAM-1-binding peptide targeted cationic liposomes containing NLRP3 siRNA to modulate LDL transcytosis as a novel therapy for experimental atherosclerosis.
Bisdemethoxycurcumin Alleviates Dextran Sodium Sulfate-Induced Colitis via Inhibiting NLRP3 Inflammasome Activation and Modulating the Gut Microbiota in Mice.
Z. morio Hemolymph Relieves E. coli-Induced Mastitis by Inhibiting Inflammatory Response and Repairing the Blood-Milk Barrier.
MicroRNA-25-5p negatively regulates TXNIP expression and relieves inflammatory responses of brain induced by lipopolysaccharide.
Crucial Function of Caveolin-1 in Deoxynivalenol-Induced Enterotoxicity by Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis.
Reactive Oxygen Species Contributes to Type 2 Diabetic Neuropathic Pain via the Thioredoxin-Interacting Protein-NOD-Like Receptor Protein 3- N -Methyl-D-Aspartic Acid Receptor 2B Pathway.
Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.
Effect of Curcumol on NOD-Like Receptor Thermoprotein Domain 3 Inflammasomes in Liver Fibrosis of Mice.
Taraxasterol inhibits inflammation in osteoarthritis rat model by regulating miRNAs and NF-κB signaling pathway.
Sophocarpine Alleviates Isoproterenol-Induced Kidney Injury by Suppressing Inflammation, Apoptosis, Oxidative Stress and Fibrosis.
Neutrophil Extracellular Traps Mediate Bovine Endometrial Epithelial Cell Pyroptosis in Dairy Cows with Endometritis.
S100A8-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Macrophages Facilitates Liver Fibrosis Progression.
Inhibition of miR-423-5p Exerts Neuroprotective Effects in an Experimental Rat Model of Cerebral Ischemia/Reperfusion Injury.
The role of discoid domain receptor 1 on renal tubular epithelial pyroptosis in diabetic nephropathy.
Past Exposure to Cigarette Smoke Aggravates Cognitive Impairment in a Rat Model of Vascular Dementia via Neuroinflammation.
Ghrelin ameliorates diabetes-associated behavioral deficits and NLRP3 inflammasome activation via autophagic flux enhancement.
BtpB inhibits innate inflammatory responses in goat alveolar macrophages through the TLR/NF-κB pathway and NLRP3 inflammasome during Brucella infection.
GPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome.
Apigenin alleviated PA-induced pyroptosis by activating autophagy in hepatocytes.
An Experimental Study Reveals the Protective Effect of Autophagy against Realgar-Induced Liver Injury via Suppressing ROS-Mediated NLRP3 Inflammasome Pathway.
NLRP3 inflammasome as a key molecular target underlying cognitive resilience in amyotrophic lateral sclerosis.
Galectin-3 enhances atrial remodelling and arrhythmogenesis through CD98 signalling.
Platonin protects against cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasomes via BNIP3/LC3 signaling mediated autophagy.
Effectiveness of NLRP3 Inhibitor as a Non-Hormonal Treatment for ovarian endometriosis.
Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction.
The role of α5-nicotinic acetylcholine receptor/NLRP3 signaling pathway in lung adenocarcinoma cell proliferation and migration.
Curcumin improves the function of umbilical vein endothelial cells by inhibiting H(2)O(2)‑induced pyroptosis.
MicroRNA-200c-5p targets NIMA Related Kinase 7 (NEK7) to inhibit NOD-like receptor 3 (NLRP3) inflammasome activation, MODE-K cell pyroptosis, and inflammatory bowel disease in mice.
SIRT1 alleviates IL-1β induced nucleus pulposus cells pyroptosis via mitophagy in intervertebral disc degeneration.
MicroRNA-223-3p promotes pyroptosis of cardiomyocyte and release of inflammasome factors via downregulating the expression level of SPI1 (PU.1).
Ambient particulate matter exposure plus a high-fat diet exacerbate renal injury by activating the NLRP3 inflammasome and TGF-β1/Smad2 signaling pathway in mice.
Ethyl carbamate triggers ferroptosis in liver through inhibiting GSH synthesis and suppressing Nrf2 activation.
Icariin attenuates ischaemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signalling pathway in rats.
Neuroprotective effects of CysLTR antagonist on Streptococcus pneumoniae-induced meningitis in rats.
Enhanced Extracellular Matrix Degradation in Growth Plate Contributes to Manganese Deficiency-Induced Tibial Dyschondroplasia in Broiler Chicks.
Procyanidins and its metabolites by gut microbiome improves insulin resistance in gestational diabetes mellitus mice model via regulating NF-κB and NLRP3 inflammasome pathway.
3,4,5-O-tricaffeoylquinic acid with anti-radiation activity suppresses LPS-induced NLRP3 inflammasome activation via autophagy in THP-1 macrophages.
Preconditioning with procyanidin B2 protects MAC-T cells against heat exposure-induced mitochondrial dysfunction and inflammation.
Inhibition of semaphorin-3a alleviates lipopolysaccharide-induced vascular injury.
mTOR-Mediated Autophagy Regulates Fumonisin B(1)-Induced Intestinal Inflammation via Pyroptosis In Vivo and In Vitro.
CysLT(2)R Antagonist HAMI 3379 Ameliorates Post-Stroke Depression through NLRP3 Inflammasome/Pyroptosis Pathway in Gerbils.
Resolvin D1 Alleviates Mechanical Allodynia via ALX/FPR2 Receptor Targeted Nod-like Receptor Protein 3/Extracellular Signal-Related Kinase Signaling in a Neuropathic Pain Model.
Bryodulcosigenin a natural cucurbitane-type triterpenoid attenuates dextran sulfate sodium (DSS)-induced colitis in mice.
H. pylori CagA activates the NLRP3 inflammasome to promote gastric cancer cell migration and invasion.
Hepatitis B virus X mediates podocyte pyroptosis by regulating the ROS/NLRP3 signaling pathway in hepatitis B virus-associated glomerulonephritis.
Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.
The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB.
Pulsed electromagnetic field alleviates synovitis and inhibits the NLRP3/Caspase-1/GSDMD signaling pathway in osteoarthritis rats.
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
Lactobacillus rhamnosus Ameliorates Multi-Drug-Resistant Bacillus cereus-Induced Cell Damage through Inhibition of NLRP3 Inflammasomes and Apoptosis in Bovine Endometritis.
The Role of NF-κB/NLRP3 Inflammasome Signaling Pathway in Attenuating Pyroptosis by Melatonin Upon Spinal Nerve Ligation Models.
Crosstalk Between RPE Cells and Choroidal Endothelial Cells via the ANXA1/FPR2/SHP2/NLRP3 Inflammasome/Pyroptosis Axis Promotes Choroidal Neovascularization.
Alliin alleviates LPS-induced pyroptosis via promoting mitophagy in THP-1 macrophages and mice.
Effect of nonylphenol on the colonic mucosa in rats and intervention with zinc-selenium green tea (Camellia sinensis).
Development of a prognostic pyroptosis-related gene signature for head and neck squamous cell carcinoma patient.
Autophagy-based unconventional secretion of HMGB1 in glioblastoma promotes chemosensitivity to temozolomide through macrophage M1-like polarization.
Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways.
Jinlida granules ameliorate the high-fat-diet induced liver injury in mice by antagonising hepatocytes pyroptosis.
ATG5-Mediated Autophagy May Inhibit Pyroptosis to Ameliorate Oleic Acid-Induced Hepatocyte Steatosis.
Сyclooxygenase-2 Inhibitor Parecoxib Reduces LPS-Induced Activation of BV2 Microglia Cells.
Identification of key proteins of cytopathic biotype bovine viral diarrhoea virus involved in activating NF-κB pathway in BVDV-induced inflammatory response.
FGF5 protects heart from sepsis injury by attenuating cardiomyocyte pyroptosis through inhibiting CaMKII/NFκB signaling.
Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Targeting the Gut Microbiota Accompanied by the TLR4/NF-κB/NLRP3 Cascade Response In Vivo.
FGF5 alleviated acute lung injury via AKT signal pathway in endothelial cells.
The selective NLRP3 inflammasome inhibitor MCC950 improves isoproterenol-induced cardiac dysfunction by inhibiting cardiomyocyte senescence.
Treadmill training mitigates bone deterioration via inhibiting NLRP3/Caspase1/IL-1β signaling in aged rats.
Inhibited transcription factor EB function induces reactive oxygen species overproduction to promote pyroptosis in cadmium-exposed renal tubular epithelial cells.
Effects of resveratrol and its derivative pterostilbene on hepatic injury and immunological stress of weaned piglets challenged with lipopolysaccharide.
Ubiquitin-specific protease 47 regulates intestinal inflammation through deubiquitination of TRAF6 in epithelial cells.
Bacillus subtilis WB800N alleviates diabetic wounds in mice by regulating gut microbiota homeostasis and TLR2.
Paeoniflorin ameliorates diabetic liver injury by targeting the TXNIP-mediated NLRP3 inflammasome in db/db mice.
Rhodiola crenulate alleviates hypobaric hypoxia-induced brain injury via adjusting NF-κB/NLRP3-mediated inflammation.
Mucin O-glycan-microbiota axis orchestrates gut homeostasis in a diarrheal pig model.
Forsythiaside A Improves the Inhibitory Efficiency of Recombinant Protein Vaccines against Bovine Viral Diarrhea Virus Infection.
Anti-depressant effects of acupuncture: The insights from NLRP3 mediated pyroptosis and inflammation.
Resolution of systemic complications in Schistosoma mansoni-infected mice by concomitant treatment with praziquantel and Schisandrin B.
Alda-1, an Activator of ALDH2, Improves Postresuscitation Cardiac and Neurological Outcomes by Inhibiting Pyroptosis in Swine.
Ginsenoside Rd attenuates cerebral ischemia/reperfusion injury by exerting an anti-pyroptotic effect via the miR-139-5p/FoxO1/Keap1/Nrf2 axis.
Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice.
Tubastatin A Improves Post-Resuscitation Myocardial Dysfunction by Inhibiting NLRP3-Mediated Pyroptosis Through Enhancing Transcription Factor EB Signaling.
ATP6AP2 knockdown in cardiomyocyte deteriorates heart function via compromising autophagic flux and NLRP3 inflammasome activation.
Platycodon grandiflorum root fermentation broth reduces inflammation in a mouse IBD model through the AMPK/NF-κB/NLRP3 pathway.
Dietary Tryptophan Supplementation Improves Antioxidant Status and Alleviates Inflammation, Endoplasmic Reticulum Stress, Apoptosis, and Pyroptosis in the Intestine of Piglets after Lipopolysaccharide Challenge.
PPT1 Reduction Contributes to Erianin-Induced Growth Inhibition in Oral Squamous Carcinoma Cells.
The Ferroptosis-NLRP1 Inflammasome: The Vicious Cycle of an Adverse Pregnancy.
Caspase-1 Inhibitor Reduces Pyroptosis Induced by Brain Death in Kidney.
Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway.
Si-Miao-Yong-An Decoction Maintains the Cardiac Function and Protects Cardiomyocytes from Myocardial Ischemia and Reperfusion Injury.
P2X7 Receptor Induces Pyroptotic Inflammation and Cartilage Degradation in Osteoarthritis via NF-κB/NLRP3 Crosstalk.
Moxibustion Ameliorates Ovarian Reserve in Rats by Mediating Nrf2/HO-1/NLRP3 Anti-Inflammatory Pathway.
Antioral Squamous Cell Carcinoma Effects of Carvacrol via Inhibiting Inflammation, Proliferation, and Migration Related to Nrf2/Keap1 Pathway.
Tongxinluo Exerts Inhibitory Effects on Pyroptosis and Amyloid-β Peptide Accumulation after Cerebral Ischemia/Reperfusion in Rats.
The Role of Exercise in Reducing Hyperlipidemia-Induced Neuronal Damage in Apolipoprotein E-Deficient Mice.
The Dietary Supplement γ-Oryzanol Attenuates Hepatic Ischemia Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress and HMGB1/NLRP3 Inflammasome.
Destructive Effects of Pyroptosis on Homeostasis of Neuron Survival Associated with the Dysfunctional BBB-Glymphatic System and Amyloid-Beta Accumulation after Cerebral Ischemia/Reperfusion in Rats.
Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF-κB/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of Preeclampsia.
Rufinamide (RUF) suppresses inflammation and maintains the integrity of the blood-brain barrier during kainic acid-induced brain damage.
Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson's Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment.
Mesenchymal Stem Cells Alleviate Post-resuscitation Cardiac and Cerebral Injuries by Inhibiting Cell Pyroptosis and Ferroptosis in a Swine Model of Cardiac Arrest.
Yi-Zhi-Fang-Dai Formula Exerts Neuroprotective Effects Against Pyroptosis and Blood-Brain Barrier-Glymphatic Dysfunctions to Prevent Amyloid-Beta Acute Accumulation After Cerebral Ischemia and Reperfusion in Rats.
Edaravone Plays Protective Effects on LPS-Induced Microglia by Switching M1/M2 Phenotypes and Regulating NLRP3 Inflammasome Activation.
Inflammasome-Induced Osmotic Pressure and the Mechanical Mechanisms Underlying Astrocytic Swelling and Membrane Blebbing in Pyroptosis.
Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway.
LPS Mediates Bovine Endometrial Epithelial Cell Pyroptosis Directly Through Both NLRP3 Classical and Non-Classical Inflammasome Pathways.
Sinapic Acid Reduces Oxidative Stress and Pyroptosis via Inhibition of BRD4 in Alcoholic Liver Disease.
Pin1 Promotes NLRP3 Inflammasome Activation by Phosphorylation of p38 MAPK Pathway in Septic Shock.
H(2)S alleviates aortic aneurysm and dissection: Crosstalk between transforming growth factor 1 signaling and NLRP3 inflammasome.
IF1 inactivation attenuates experimental colitis through downregulation of neutrophil infiltration in colon mucosa.
Plasma exosomes derived from patients with intestinal Behçet's syndrome induce intestinal epithelial cell pyroptosis.
Reactive oxygen species induced by uric acid promote NRK‑52E cell apoptosis through the NEK7‑NLRP3 signaling pathway.
Ulinastatin protects against sepsis‑induced myocardial injury by inhibiting NLRP3 inflammasome activation.
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
(-)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD.
Downregulation of phosphoglycerate mutase 5 improves microglial inflammasome activation after traumatic brain injury.
Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.
MCC950 attenuates doxorubicin-induced myocardial injury in vivo and in vitro by inhibiting NLRP3-mediated pyroptosis.
6-Gingerol protects against cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1 / FAF1 complex dissociation-mediated autophagy.
TNFAIP3-upregulated RIP3 exacerbates acute pancreatitis via activating NLRP3 inflammasome.
Inhibition of the NLRP3 inflammasome with MCC950 prevents chronic social isolation-induced depression-like behavior in male mice.
Indole-3-Propionic Acid, a Functional Metabolite of Clostridium sporogenes, Promotes Muscle Tissue Development and Reduces Muscle Cell Inflammation.
MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs.
Moderate-intensity exercise alleviates pyroptosis by promoting autophagy in osteoarthritis via the P2X7/AMPK/mTOR axis.
Astaxanthin attenuated hyperuricemia and kidney inflammation by inhibiting uric acid synthesis and the NF-κ B/NLRP3 signaling pathways in potassium oxonate and hypoxanthine-induced hyperuricemia mice.
Paeoniflorin inhibited nod-like receptor protein-3 inflammasome and NF-κB-mediated inflammatory reactions in diabetic foot ulcer by inhibiting the chemokine receptor CXCR2.
Enterococcus Faecalis activates NLRP3 inflammasomes leading to increased interleukin-1 beta secretion and pyroptosis of THP-1 macrophages.
17β-Estradiol Reduces Demyelination in Cuprizone-fed Mice by Promoting M2 Microglia Polarity and Regulating NLRP3 Inflammasome.
Cordyceps acid alleviates lung cancer in nude mice.
Trueperella pyogenes pyolysin inhibits lipopolysaccharide-induced inflammatory response in endometrium stromal cells via autophagy- and ATF6-dependent mechanism.
Golgi phosphoprotein 3 promotes the proliferation of gallbladder carcinoma cells via regulation of the NLRP3 inflammasome.
Amelioration of Juglanin against LPS-Induced Activation of NLRP3 Inflammasome in Chondrocytes Mediated by SIRT1.
Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo.
Bone marrow-derived mesenchymal stem cells attenuate silica-induced pulmonary fibrosis by inhibiting apoptosis and pyroptosis but not autophagy in rats.
Adiponectin protects obesity-related glomerulopathy by inhibiting ROS/NF-κB/NLRP3 inflammation pathway.
Galectin-9 Targets NLRP3 for Autophagic Degradation to Limit Inflammation.
Macrophage membrane-mediated targeted drug delivery for treatment of spinal cord injury regardless of the macrophage polarization states.
Activation of Interleukin-1β Release and Pyroptosis by Transmissible Gastroenteritis Virus Is Dependent on the NOD-Like Receptor Protein 3 Inflammasome in Porcine Intestinal Epithelial Cell Line.
Targeting HDAC6 attenuates nicotine-induced macrophage pyroptosis via NF-κB/NLRP3 pathway.
Melatonin ameliorates hepatic steatosis by inhibiting NLRP3 inflammasome in db/db mice.
Aberrant spinal mechanical loading stress triggers intervertebral disc degeneration by inducing pyroptosis and nerve ingrowth.
The NLRP3 inflammasome drives inflammation in ischemia/reperfusion injury after transient middle cerebral artery occlusion in mice.
BDNF corrects NLRP3 inflammasome-induced pyroptosis and glucose metabolism reprogramming through KLF2/HK1 pathway in vascular endothelial cells.
Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor α-mediated autophagy.
An In-vivo Study into the Effects of Schisandrin B in the Liver, Spleen, Kidney, and Brain of Acute Thioacetamide-intoxicated Mice.
Huoxue Qianyang Qutan recipe attenuates cardiac fibrosis by inhibiting the NLRP3 inflammasome signalling pathway in obese hypertensive rats.
Role of miR-145-5p/ CD40 in the inflammation and apoptosis of HUVECs induced by PM(2.5).
DDX3X deficiency alleviates LPS-induced H9c2 cardiomyocytes pyroptosis by suppressing activation of NLRP3 inflammasome.
MST4 attenuates NLRP3 inflammasome-mediated neuroinflammation and affects the prognosis after intracerebral hemorrhage in mice.
ESR2 regulates PINK1-mediated mitophagy via transcriptional repression of microRNA-423 expression to promote asthma development.
Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia.
Sub-chronic exposure to realgar induces liver injury via upregulating the TXNIP/NLRP3 pathway and disturbing bile acid homeostasis in mice.
Exposure to DEHP induces testis toxicity and injury through the ROS/mTOR/NLRP3 signaling pathway in immature rats.
Prototheca spp. induce an inflammatory response via mtROS-mediated activation of NF-κB and NLRP3 inflammasome pathways in bovine mammary epithelial cell cultures.
FNDC5 induces M2 macrophage polarization and promotes hepatocellular carcinoma cell growth by affecting the PPARγ/NF-κB/NLRP3 pathway.
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.
Emodin ameliorates acute pancreatitis-induced lung injury by suppressing NLRP3 inflammasome-mediated neutrophil recruitment.
TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation.
Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.
Low NLRP3 expression predicts a better prognosis of colorectal cancer.
Salidroside alleviates diabetic neuropathic pain through regulation of the AMPK-NLRP3 inflammasome axis.
Protective Role of Coenzyme Q10 in Acute Sepsis-Induced Liver Injury in BALB/c Mice.
ATP-Sensitive Potassium Channels Mediate the Cardioprotective Effect of Panax notoginseng Saponins against Myocardial Ischaemia-Reperfusion Injury and Inflammatory Reaction.
Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BALB/c Mice.
Maresin 1 Attenuates Radicular Pain Through the Inhibition of NLRP3 Inflammasome-Induced Pyroptosis via NF-κB Signaling.
Resatorvid Relieves Breast Cancer Complicated with Depression by Inactivating Hippocampal Microglia Through TLR4/NF-κB/NLRP3 Signaling Pathway.
Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects via the TXNIP-NLRP3-GSDMD Axis.
Resolvin D1 ameliorates Inflammation-Mediated Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in rats by Modulating A20 and NLRP3 Inflammasome.
Cardamonin Reduces Acetaminophen-Induced Acute Liver Injury in Mice via Activating Autophagy and NFE2L2 Signaling.
Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4.
CoenzymeQ10-Induced Activation of AMPK-YAP-OPA1 Pathway Alleviates Atherosclerosis by Improving Mitochondrial Function, Inhibiting Oxidative Stress and Promoting Energy Metabolism.
Carvacrol may alleviate vascular inflammation in diabetic db/db mice.
Humanin Ameliorates Free Fatty Acid-Induced Endothelial Inflammation by Suppressing the NLRP3 Inflammasome.
Antimicrobial Effect of Zophobas morio Hemolymph against Bovine Mastitis Pathogens.
Inflammasome/NF-κB translocation inhibition via PPARγ agonist mitigates inorganic mercury induced nephrotoxicity.
Puerarin ameliorates retinal ganglion cell damage induced by retinal ischemia/reperfusion through inhibiting the activation of TLR4/NLRP3 inflammasome.
Mesenchymal stem cells-derived exosomes ameliorate intervertebral disc degeneration through inhibiting pyroptosis.
Peptidome analysis of cerebrospinal fluid in neonates with hypoxic-ischemic brain damage.
LncRNA GAS5 inhibits NLRP3 inflammasome activation-mediated pyroptosis in diabetic cardiomyopathy by targeting miR-34b-3p/AHR.
UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression.
Self-recovery study of the adverse effects of fluoride on small intestine: Involvement of pyroptosis induced inflammation.
Oroxylin A inhibits carcinogen-induced skin tumorigenesis through inhibition of inflammation by regulating SHCBP1 in mice.
Peritoneal M2 macrophage transplantation as a potential cell therapy for enhancing renal repair in acute kidney injury.
Resveratrol protects against CIH-induced myocardial injury by targeting Nrf2 and blocking NLRP3 inflammasome activation.
TNF-α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury.
Laquinimod inhibits MMP+ induced NLRP3 inflammasome activation in human neuronal cells.
Geniposide inhibits NLRP3 inflammasome activation via autophagy in BV-2 microglial cells exposed to oxygen-glucose deprivation/reoxygenation.
Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1/Parkin signaling pathway.
RDP3, A Novel Antigout Peptide Derived from Water Extract of Rice.
Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264.7 cells: The role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK.
Hyperglycemia suppresses the regulatory effect of hypoxia-inducible factor-1α in pulmonary Aspergillus fumigatus infection.
Discovery of novel TNNI3K inhibitor suppresses pyroptosis and apoptosis in murine myocardial infarction injury.
Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome and uric acid reabsorption.
Silibinin inhibits migration and invasion of breast cancer MDA-MB-231 cells through induction of mitochondrial fusion.
Lactobacillus johnsonii L531 ameliorates enteritis via elimination of damaged mitochondria and suppression of SQSTM1-dependent mitophagy in a Salmonella infantis model of piglet diarrhea.
Inhibition of the SIRT1 signaling pathway exacerbates endoplasmic reticulum stress induced by renal ischemia/reperfusion injury in type 1 diabetic rats.
α-synuclein promotes progression of Parkinson's disease by upregulating autophagy signaling pathway to activate NLRP3 inflammasome.
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.
The protective effects of phoenixin-14 against lipopolysaccharide-induced inflammation and inflammasome activation in astrocytes.
A Novel Mechanism of Specialized Proresolving Lipid Mediators Mitigating Radicular Pain: The Negative Interaction with NLRP3 Inflammasome.
Lactobacillus johnsonii L531 Ameliorates Escherichia coli-Induced Cell Damage via Inhibiting NLRP3 Inflammasome Activity and Promoting ATG5/ATG16L1-Mediated Autophagy in Porcine Mammary Epithelial Cells.
Inhibiting pannexin-1 alleviates sepsis-induced acute kidney injury via decreasing NLRP3 inflammasome activation and cell apoptosis.
Saikosaponin-d ameliorates dextran sulfate sodium-induced colitis by suppressing NF-κB activation and modulating the gut microbiota in mice.
Salidroside Decreases Atherosclerosis Plaque Formation via Inhibiting Endothelial Cell Pyroptosis.
IFN Regulatory Factor 1 Mediates Macrophage Pyroptosis Induced by Oxidized Low-Density Lipoprotein in Patients with Acute Coronary Syndrome.
NLRP3 inflammasome activation by estrogen promotes the progression of human endometrial cancer.
Detection of Exosomal PD-L1 RNA in Saliva of Patients With Periodontitis.
NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis.
Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation.
Iguratimod (T-614) attenuates severe acute pancreatitis by inhibiting the NLRP3 inflammasome and NF-κB pathway.
Glycyrrhizin attenuates hepatic ischemia-reperfusion injury by suppressing HMGB1-dependent GSDMD-mediated kupffer cells pyroptosis.
Conjugated Linoleic Acid Ameliorates High Fructose-Induced Hyperuricemia and Renal Inflammation in Rats via NLRP3 Inflammasome and TLR4 Signaling Pathway.
MicroRNA-135b alleviates MPP(+)-mediated Parkinson's disease in in vitro model through suppressing FoxO1-induced NLRP3 inflammasome and pyroptosis.
Enterococcus faecalis induces apoptosis and pyroptosis of human osteoblastic MG63 cells via the NLRP3 inflammasome.
Involvement of NLRP3 inflammasome in methamphetamine-induced microglial activation through miR-143/PUMA axis.
LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma.
Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota.
Sal B Alleviates Myocardial Ischemic Injury by Inhibiting TLR4 and the Priming Phase of NLRP3 Inflammasome.
Protective effects of microRNA-22-3p against retinal pigment epithelial inflammatory damage by targeting NLRP3 inflammasome.
Role of Thymoquinone in Cardiac Damage Caused by Sepsis from BALB/c Mice.
NLRP3/IL1β inflammasome associated with the aging bladder triggers bladder dysfunction in female rats.
Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Activation of NLRP3 and NLRC4 Inflammasomes With Differential Requirement for ASC.
Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis.
Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway.
Tumour YAP1 and PTEN expression correlates with tumour-associated myeloid suppressor cell expansion and reduced survival in colorectal cancer.
Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response.
MCMV triggers ROS/NLRP3-associated inflammasome activation in the inner ear of mice and cultured spiral ganglion neurons, contributing to sensorineural hearing loss.
Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts.
Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis.
Salvianolate reduces atrial fibrillation through suppressing atrial interstitial fibrosis by inhibiting TGF-β1/Smad2/3 and TXNIP/NLRP3 inflammasome signaling pathways in post-MI rats.
Anti-inflammatory capacity of Lactobacillus rhamnosus GG in monophasic variant Salmonella infected piglets is correlated with impeding NLRP6-mediated host inflammatory responses.
Analysis of the expression of NLRP3 and AIM2 in periapical lesions with apical periodontitis and microbial analysis outside the apical segment of teeth.
Protection of Mcc950 against high-glucose-induced human retinal endothelial cell dysfunction.
Comparative effects of schisandrin A, B, and C on Propionibacterium acnes-induced, NLRP3 inflammasome activation-mediated IL-1β secretion and pyroptosis.
Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.
NLRP3 inflammasome mediates contrast media-induced acute kidney injury by regulating cell apoptosis.
New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.
Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Inflammation and Cell Damage via Attenuation of ASC-Independent NLRP3 Inflammasome Activation.
PEDF Inhibits the Activation of NLRP3 Inflammasome in Hypoxia Cardiomyocytes through PEDF Receptor/Phospholipase A2.
Increased expression of NLRP3 inflammasome components and interleukin-18 in patients with bullous pemphigoid.
P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation.
Protection of seven dibenzocyclooctadiene lignans from Schisandra chinensis against serum and glucose deprivation injury in SH-SY5Y cells.
Thioredoxin-interacting protein mediates NALP3 inflammasome activation in podocytes during diabetic nephropathy.
Mulberroside A protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion.
NLRP3 deficiency ameliorates neurovascular damage in experimental ischemic stroke.
Zhou S, Jiang W, Sun Z, Zhang J, Zhang T, Ma B, Liu C, Zhang Y, Zhang L, Yan X
Journal of ethnopharmacology 2026 May 10;362:121385
Journal of ethnopharmacology 2026 May 10;362:121385
Cadmium targeting MLKL-Drp1 axis to trigger mitochondrial oxidative stress contributes to necroinflammation in rat kidney.
Lian CY, Xia WH, Sun MC, Wan XM, Zhou XL, Wang L
Journal of advanced research 2026 Mar;81:1079-1093
Journal of advanced research 2026 Mar;81:1079-1093
Microplastics release from infusion sets during intravenous infusion induces cardiovascular toxicity.
Yu H, Xiang G, He S, Zeng Z, Deng A, Yin Y, Wang Y
Environment international 2026 Mar;209:110187
Environment international 2026 Mar;209:110187
Research based on serine metabolism indicates mesenchymal stem cells alleviate psoriasis by regulating the PSPH-PINK1-Parkin-NLRP3 pathway in HaCaT.
Lin Q, Ji Y, Yang B, Zhu R, Song P, Zhao RC
Stem cell research & therapy 2026 Mar 28;17(1)
Stem cell research & therapy 2026 Mar 28;17(1)
Fibroblast-derived exosomes induce macrophage pyroptosis to mediate orthodontic bone remodeling through the mtDNA/NLRP3 axis.
Yu Q, Guo K, Yang Y, Liu H, Han Y, Yu X, Wang J, Zhao Y, Su X, Zhu K, Zheng S, Wang S, Li W, Huang Y
Journal of nanobiotechnology 2026 Mar 14;24(1)
Journal of nanobiotechnology 2026 Mar 14;24(1)
Viscum coloratum polysaccharide ameliorates hyperuricemic nephropathy by upregulating Nrf2 to inhibit TGF-β1/Smad3 and NLRP3/ASC/Caspase-1 pathways.
Zhang K, Sun S, Qiu H, Zhao H, Zhao H, Shen Y, Wang Y, Zhang Y
Journal of ethnopharmacology 2026 Mar 1;358:120981
Journal of ethnopharmacology 2026 Mar 1;358:120981
Urban particulate matter induces NLRP3/NLRP6 inflammasomes, autophagy, senescence and fibrotic responses by increasing CSF2 signaling in kidney cells.
Su RY, Chuang HC, Zheng CM, Ho LJ, Chen YJ, Lee YH, Chiu HW
Free radical biology & medicine 2026 Jun;249:1-13
Free radical biology & medicine 2026 Jun;249:1-13
Flutamide exacerbates hepatic insulin resistance in type 2 diabetic mice through overproduction of ROS and activation of NLRP3 signaling.
Zhang Y, Zhang Y, Xiang Q, Fu X, Zhang Y, Tan L, Tang H, Li S, Gong D, Guo X, Zhang Y, Wang Q, Chen L, Zheng T
International immunopharmacology 2026 Jul 1;180:116683
International immunopharmacology 2026 Jul 1;180:116683
Transducin-like enhancer of split 3 protects against lipopolysaccharide-induced inflammation through DEAD-box helicase 5-activating transcription factor 1-protein phosphatase 2 regulatory subunit 5A signaling.
Fan D, Zhong Y, Dong Y, Du M, Huang K, Li X
Journal of advanced research 2026 Jan;79:661-677
Journal of advanced research 2026 Jan;79:661-677
A bioactive protein from Dioscorea polystachya residue alleviates hydrocortisone-induced erectile dysfunction in rats via TXNIP/NLRP3 pathway inhibition.
Yu S, Zhang Y, Xi J, Feng J, Xie T, Pan D, Zhao D, Ren J, Dong Z, Liu M, Wang S
International journal of biological macromolecules 2026 Jan;335(Pt 1):149351
International journal of biological macromolecules 2026 Jan;335(Pt 1):149351
Human umbilical cord plasma derived exosome inhibit the NLRP3 inflammasome and neuro-apoptosis in traumatic spinal cord injury model.
Taheri H, Mosleh HR, Darabi L, Jahanbaz S, Mirni HK, Farahani RM, Aliaghaei A, Nazarian H, Bahar R, Hasanzadeh M, Tahmasebinia F, Beirami A, Abbaszadeh HA, Darabi S
3 Biotech 2026 Jan;16(1):33
3 Biotech 2026 Jan;16(1):33
Sex-Specific Downregulation of CDK5RAP3 Exacerbates ER Stress-Mediated Inflammation and Apoptosis in CCl(4)-Induced Acute Liver Injury.
Ruan J, Dong Q, Xu F, Jin Y, Yang Y, Li J, Cai Y
Genes 2026 Jan 8;17(1)
Genes 2026 Jan 8;17(1)
Free Fatty Acids and Endotoxins Synergically Induce Pyroptosis in Bovine Hepatocytes.
Li D, Tian Y, Tian L, Yu H, Zhang L, Wang S, Lei C, Long P, Peng T, Liu L, Zhou Y
Metabolites 2026 Jan 8;16(1)
Metabolites 2026 Jan 8;16(1)
RRx-001 ameliorates astrocyte pyroptosis by regulating LCN2-NLRP3 inflammasome activation in an MPTP-induced parkinson's disease mouse model.
Shu H, Huang X, Su Z, Liang F, Ding L, Luo K, Liu T, Huang W, Xiao Y, Zhang W, Xu P
Cellular and molecular life sciences : CMLS 2026 Jan 7;83(1):60
Cellular and molecular life sciences : CMLS 2026 Jan 7;83(1):60
Luteolin alleviates PCOS by inhibiting AR/STAT3/NLRP3-mediated granulosa cell pyroptosis.
Ouyang X, Tang H, Yang Y, Hao X, Jiang X, Zhou Q, Li L
Journal of ovarian research 2026 Jan 24;19(1):63
Journal of ovarian research 2026 Jan 24;19(1):63
Phafin2 modulates the aggregation of NLRP3 on dispersed trans-Golgi network.
Li Y, Zheng K, Chen C, Wu Y, Li S, Zhou W, Liu X
Biochimica et biophysica acta. Proteins and proteomics 2026 Jan 1;1874(1):141101
Biochimica et biophysica acta. Proteins and proteomics 2026 Jan 1;1874(1):141101
Systematic Identification and Functional Validation of CASP10 as a DNA-Damage-Responsive Driver of Endothelial Pyroptosis in Atherosclerosis.
Meng X, Zhang K, Xi Y, Wang Z, Zhu X, Zhang W
Journal of cellular and molecular medicine 2026 Feb;30(4):e71060
Journal of cellular and molecular medicine 2026 Feb;30(4):e71060
NLRP3-Caspase-1 Axis in Human Adipose Tissue Crown-Like Structures: A Potential Mediator of Inflammation and the Effects of Bariatric Surgery.
Palomäki VA, Väyrynen JP, Koivukangas V, Meriläinen S, Karttunen TJ, Lehenkari P
Immunity, inflammation and disease 2026 Feb;14(2):e70312
Immunity, inflammation and disease 2026 Feb;14(2):e70312
Tyrosinase Cross-Linked PEG Hydrogels with DAT and DATT as Artificial Substrates: Design, Structure, and Functions.
Racheva M, Basalo Lourido J, Gurdal EE, Herbst M, Bayar S, Radzik D, Bähr E, Zwies C, Neffe AT, Pietzsch M, Lendlein A, Wischke C
Biomacromolecules 2026 Feb 9;27(2):1317-1336
Biomacromolecules 2026 Feb 9;27(2):1317-1336
Sulfated Pelvetia siliquosa Polysaccharides Attenuate Pyroptosis via NF-κB Pathway Inhibition Against Calcium Oxalate Stone Formation.
Tong XY, Chen XW, Zhang JY, Ouyang JM
Marine drugs 2026 Feb 8;24(2)
Marine drugs 2026 Feb 8;24(2)
Rift Valley fever virus activates multiple cell death pathways in neurons.
Connors KA, Frey ZD, Demers MJ, Midgett M, Williams C, Reed DS, Wills ZP, Hartman AL
Journal of virology 2026 Feb 17;100(2):e0174225
Journal of virology 2026 Feb 17;100(2):e0174225
Carbon-based nanomaterials induce ovarian dysfunction via NLRP3 inflammasome-mediated pyroptosis in granulosa cells.
Wei S, Chen D, Wang J, Wu C, Tang W, Xue L, Feng Y, Dai Y, Guo Y, Zheng P, Song Y, Dai J, Wang S, Wu M
Journal of advanced research 2026 Feb 12;
Journal of advanced research 2026 Feb 12;
Micro/nanoplastics induce thyroid follicular cell pyroptosis to trigger thyrotoxicity by activating NF-κB signaling.
Fu F, Chen Y, Luo H, Ruan H
Annals of medicine 2026 Dec;58(1):2624175
Annals of medicine 2026 Dec;58(1):2624175
Biosynthesis of Lysosomally Escaped Apoptotic Bodies Inhibits Inflammasome Synthesis in Macrophages.
Mao J, Xia W, Wu Y, Li M, Zhao Y, Zhai P, Zhang Y, Zan T, Cui W, Sun X
Research (Washington, D.C.) 2025;8:0581
Research (Washington, D.C.) 2025;8:0581
Perfluorooctane sulfonate induces hepatotoxicity through promoting inflammation, cell death and autophagy in a rat model.
Tang L, Zhu J, Zhuge S, Yu J, Jiang G
The Journal of toxicological sciences 2025;50(2):45-55
The Journal of toxicological sciences 2025;50(2):45-55
G Protein-Coupled Receptor 30 Attenuates Neuronal Pyroptosis Induced by Subarachnoid Hemorrhage.
Peng J, Hu X, He J, Xia Y
Mediators of inflammation 2025;2025:3585885
Mediators of inflammation 2025;2025:3585885
Subchronic Chlorpyrifos Exposure Induces Thyroid Follicular Cell Pyroptosis to Exacerbate Thyroid Toxicity by Modulating Nrf2/Keap1/NF-κB Pathway in Male Mice.
Gu B, Chen Y, Xu H, Zhan K, Zhu K, Luo H, Huang Y, Zeng H, Zheng W, Tian K, Ruan H
Journal of inflammation research 2025;18:9307-9320
Journal of inflammation research 2025;18:9307-9320
TMAO Induces Vascular Endothelial Cells Pyroptosis Through TET2-CYTB-ROS Pathway.
Xia L, Wang Z, Chen X
Journal of inflammation research 2025;18:8719-8733
Journal of inflammation research 2025;18:8719-8733
Reduced Thioredoxin Regulates IL-1β Secretion via NLRP3 of IL-1β+ Alveolar Macrophages in COPD.
Wang L, Shi R, Li Z, Ma R, Wang C, Xu C, Guo R, Xiao C, Du X, Yang W
Journal of inflammation research 2025;18:8563-8578
Journal of inflammation research 2025;18:8563-8578
Gubi Decoction Ameliorates Porous Cartilage Endplate in an Intervertebral Disc Degeneration Model Mouse Through Inhibition of NF-κB Activity and Pyroptosis.
Yao S, Li Y, Ruan H, Wu L, Zeng H
Journal of inflammation research 2025;18:5293-5309
Journal of inflammation research 2025;18:5293-5309
Effect of Acupotomy Modulation of NLRP3/Caspase-1/GSDMD Pathway on Chondrocyte Pyroptosis in Knee Osteoarthritis.
Wang Y, Chen Y, Yang Y, Zhou Y, Yang Y, Zhu J
Journal of pain research 2025;18:4935-4945
Journal of pain research 2025;18:4935-4945
Systemic Lupus Erythematosus Stimulates Chondrocyte Pyroptosis to Aggravate Arthritis via Suppression of NRF-2/KEAP-1 and NF-κB Pathway.
Shen S, Fang X, Zhang H, Lang T, Fu F, Du Y, Xu T, Jin H, Tong P, Wu C, Hu C, Ruan H
Journal of inflammation research 2025;18:4233-4250
Journal of inflammation research 2025;18:4233-4250
MCC950 Alleviates Experimental Autoimmune Neuritis by Inhibiting NLRP3 Inflammasome Activity and Down-Regulating Interleukin-23/Interleukin-17 Axis Expression.
Li Y, Li X, Gu T, Wang L, Song M, Yang L, Huang Q, Yang J
Journal of inflammation research 2025;18:17113-17127
Journal of inflammation research 2025;18:17113-17127
Glycochenodeoxycholic acid induces the release of IL-1beta from L02 cells via the NLRP3/caspase-1/GSDMD pathway to activate LX2 cells.
Li J, Han L, Feng S, Lin G, Zou G, Huang T, Ran T, Zhao X
Journal of inflammation research 2025;18:15429-15440
Journal of inflammation research 2025;18:15429-15440
Electroacupuncture Regulates Oxidative Stress-Mediated NLRP3/ASC/Caspase-1 Pathway to Inhibit Microglial Activation: Alleviating Neuroinflammation and Depression in IBD.
Li Z, Cao S, Yang J, Chen L, Jia L, Lu P, Liu J, Liu M, Liu Q
Journal of inflammation research 2025;18:11935-11950
Journal of inflammation research 2025;18:11935-11950
Electroacupuncture alleviates Parkinson's disease by inhibiting the NLRP3 inflammasome pathway.
Kang M, Cai J, Yi W, Zhang B, Ai L, Ning B, Dong J, Chen L, Fu W
American journal of translational research 2025;17(5):3619-3629
American journal of translational research 2025;17(5):3619-3629
Treadmill exercise alleviates Alzheimer's disease pathologies in APP/PS1 mice through modulation of microglial glucose metabolic reprogramming.
Liang F, Sun F, Guo C, Zhong H
Frontiers in aging neuroscience 2025;17:1734837
Frontiers in aging neuroscience 2025;17:1734837
Shanling Jiangzhi Tea treats hyperuricemia by inhibition of COMT/MAOA signaling pathway and p53/SERPINE1/NLRP3 signaling pathway.
Chen HN, Wu HZ, Yang YF
Frontiers in endocrinology 2025;16:1623111
Frontiers in endocrinology 2025;16:1623111
Trapidil attenuates diabetic cardiomyopathy via GPX3/Nrf2-mediated inhibition of myocardial pyroptosis.
Wang Z, Sun Y, Wang J, Xu Q, Wang L, Zhang Q, Song J, Wang Y, Qi Z
Frontiers in pharmacology 2025;16:1566622
Frontiers in pharmacology 2025;16:1566622
Tetramethylpyrazine alleviates acute pancreatitis inflammation by inhibiting pyroptosis via the NRF2 pathway.
Li H, Gao Y, Huang M, Zhang H, Wu Q, Huang Y, Ye X, Chen W
Frontiers in pharmacology 2025;16:1557681
Frontiers in pharmacology 2025;16:1557681
Rhodiola rosea-derived exosome-like nanovesicles inhibit vascular endothelial pyroptosis in the treatment of limb skeletal muscle ischemic injury through the TXNIP/NLNP3 pathway.
Liu D, Zhang Z, Wang Y, Liang X, Chang Y, Wang C, Guo Y, Zhang S, Zhou J, Zhang M, Shen H, Zhang X, Gao W
Regenerative biomaterials 2025;12:rbaf113
Regenerative biomaterials 2025;12:rbaf113
Combined effects of quinic acid and isochlorogenic acid B on LPS-induced inflammation and pyroptosis in MAC-T cells and mouse mammary glands.
Lv X, Long Q, Kang Y, Lin T, Jiang C
Frontiers in veterinary science 2025;12:1476302
Frontiers in veterinary science 2025;12:1476302
Cold-Induced RNA-Binding Protein (CIRP) Affects Cerebral Ischemia-Reperfusion Injury Through NF-κB Pathway.
Fan Y, Wei J, Lin L, Lin J, Li X, Xu L, Zhou X, Li Y, Yang Y
Molecular neurobiology 2025 Sep;62(9):12205-12220
Molecular neurobiology 2025 Sep;62(9):12205-12220
M2 Macrophages-Derived Exosomes Inhibited Podocyte Pyroptosis via lncRNA AFAP1-AS1/EZH2 Axis.
Zhan Q, Liu H, Zhao M, Huang H
Clinical and experimental pharmacology & physiology 2025 Sep;52(9):e70056
Clinical and experimental pharmacology & physiology 2025 Sep;52(9):e70056
Tangzhiqing Exacerbates Oxidized Low-Density Lipoprotein-Induced Cell Pyroptosis Through Activation of NLRP3 Inflammasome in Human Umbilical Vein Endothelial Cells.
Chen R, Zhou Z, Song Z, Feng W, Ding X, Zhang H, Wang Y
Cell biology international 2025 Sep;49(9):1173-1183
Cell biology international 2025 Sep;49(9):1173-1183
Multi-omics profiling reveals infectious bursal disease virus-induced alterations in gene expression and metabolism in chicken bursa of fabricius.
Song C, Li S, Yuan Y, Gao W, Qiu X, Tan L, Sun Y, Tang N, Qu Y, Liao Y, Ding C
Veterinary microbiology 2025 Sep;308:110635
Veterinary microbiology 2025 Sep;308:110635
Curcumin mitigates testicular ischemia-reperfusion injury by suppressing NLRP3-mediated pyroptosis.
Hu Z, Wang J, Ning J, Cheng F
Molecular immunology 2025 Sep;185:71-80
Molecular immunology 2025 Sep;185:71-80
Tongxinluo alleviates myocardial ischemia-reperfusion injury by inhibiting the pyroptosis of endothelial cells via the NLRP3/Caspase-1/GSDMD signaling pathway.
Wu X, Hou YL, Wang TX, Chang LP, Zhou HR, Wang MY, Wu YL
Journal of molecular histology 2025 Sep 8;56(5):302
Journal of molecular histology 2025 Sep 8;56(5):302
A Novel Mechanism of Chlorogenic Acid in Cardioprotection: Blocking NLRP3 Inflammasome via Ca(2+)/CaMKIIα Signaling in Sepsis-Induced Cardiomyopathy.
Meng H, Chen K, Lu Z, Yu W, Hu X, Xu H, Zhou S, Peng S, Guo X, Sun Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 30;39(18):e71046
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 30;39(18):e71046
Melatonin attenuates ischemia-reperfusion-induced acute kidney injury by regulating abnormal autophagy and pyroptosis through SIRT1-mediated p53 deacetylation.
Sun C, Liu J, Li H, Yan Y
International immunopharmacology 2025 Sep 23;162:115092
International immunopharmacology 2025 Sep 23;162:115092
Tetrabromophthalate bis(2-ethylhexyl) ester (TBPH) exposure induces renal inflammation injury by activating MAVS-IRF3 signaling pathway in vitro and in vivo models.
Xing B, Lan H, Li H
Ecotoxicology and environmental safety 2025 Sep 15;303:118920
Ecotoxicology and environmental safety 2025 Sep 15;303:118920
MAO-A inhibition alleviates sepsis-driven lung injury via Nrf2/HO-1 pathway activation and suppression of pyroptosis.
Li M, Li H, Gong L, Chen X, Dai J, Tian J, Yin X, Yu Q
Journal of molecular histology 2025 Sep 13;56(5):310
Journal of molecular histology 2025 Sep 13;56(5):310
Gestational zearalenone causes fetal intrauterine growth restriction partially through deriving ROS-Drp1 mediated placental PANoptosis.
Liu JR, Wu FN, Lin S, Chen C, Liu Y, Fan JW, Hong Q, Chen YH
Ecotoxicology and environmental safety 2025 Sep 1;302:118636
Ecotoxicology and environmental safety 2025 Sep 1;302:118636
(Z)-Ligustilide alleviates intervertebral disc degeneration by suppressing nucleus pulposus cell pyroptosis via Atg5/NLRP3 axis.
Wang J, Fan C, Zhang Y, Hua D, Ji Z, He W, Deng Y, Geng D, Wu X, Mao H
Science China. Life sciences 2025 Oct;68(10):2965-2981
Science China. Life sciences 2025 Oct;68(10):2965-2981
Canagliflozin Attenuates Podocyte Inflammatory Injury through Suppressing the TXNIP/NLRP3 Signaling Pathway in Diabetic Kidney Disease Mice.
Li S, Wang J, Chen Y, Cheng Y, Wang Y, Xu N, Wang H, Wang L, Chi Y, Ye X, Shi Y, Fang J, Yao X, Huang J, Xia Q, Bai T, Zhu B
Inflammation 2025 Oct;48(5):3180-3193
Inflammation 2025 Oct;48(5):3180-3193
Baicalein Reduces Pyroptosis of Acinar Cells in Hyperlipidemic Acute Pancreatitis by Inhibiting M1 Polarization of Macrophages via the HMGB1/TLR4/NLRP3 Pathway.
Wang X, Zhou Y, Liu Y, Mo T, Chen Z, Zhang Y, Yang L, Liu P
Inflammation 2025 Oct;48(5):3130-3145
Inflammation 2025 Oct;48(5):3130-3145
Astragaloside IV-PESV facilitates pyroptosis by enhancing palmitoylation of GSDMD protein mediated by ZDHHC1.
You X, Li H, Li Q, Zhang Q, Cao Y, Fu W, Wang B
Naunyn-Schmiedeberg's archives of pharmacology 2025 Oct;398(10):13925-13939
Naunyn-Schmiedeberg's archives of pharmacology 2025 Oct;398(10):13925-13939
Transcriptome profiling reveals a peculiarity of host immune responses to PA-X protein of H9N2 influenza A virus.
Wu J, Wan Z, Shao H, Qian K, Ye J, Qin A
Veterinary microbiology 2025 Oct;309:110702
Veterinary microbiology 2025 Oct;309:110702
Indole-3 propionate inhibits NF-κB/NLRP3-mediated osteoclastogenesis and improves bone quality in high-fat-diet induced obese mice.
Wu R, Kong Y, Li J, Chen H, Jiao Y, Sun C, Ju Y
Biochimica et biophysica acta. Molecular basis of disease 2025 Oct;1871(7):167952
Biochimica et biophysica acta. Molecular basis of disease 2025 Oct;1871(7):167952
CTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway.
Li L, Zuo A, Yin R, Liu Q, Liu C, Li N, Xu D, Zhang S, Li J, Lei S, Ruan S, Li T, Guo Y
Cell death & disease 2025 Oct 7;16(1):710
Cell death & disease 2025 Oct 7;16(1):710
Macrophage NLRP3 activation and IL-1β release drive osimertinib-induced antitumor immunity.
Yu H, Sun X, Li Y, Pan J, Liu X, He H, Wu H, Sun Y, Pan Y, Qian X
Journal for immunotherapy of cancer 2025 Oct 5;13(10)
Journal for immunotherapy of cancer 2025 Oct 5;13(10)
TREM-1 Promotes Microglial Pyroptosis and Mitochondrial Fission in Intracerebral Hemorrhage via the PI3K/AKT Pathway.
An Y, Zhai T, Wang F, Zhang K, Feng M, Song D, Li Z, Guo F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 15;39(19):e71115
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 15;39(19):e71115
Bisphenol S as an emerging osteotoxicant: Mechanistic insights from osteoblasts and zebrafish models.
Shi X, Xie H, Liu C, Wu K, Huang W
Ecotoxicology and environmental safety 2025 Oct 15;305:119240
Ecotoxicology and environmental safety 2025 Oct 15;305:119240
The effect of puerarin on the NLRP3 Inflammasome pathway and MMP-9 in aortic dissection of ApoE(-/-) mice.
Cai Z, Yan T, Zhang B, Cao X, Feng M, Zhang W, Zhang H, Wang X
International immunopharmacology 2025 Oct 10;163:115286
International immunopharmacology 2025 Oct 10;163:115286
NEK7 mediates ESRD-associated endothelial injury by activating the NLRP3 inflammasome.
Sun L, Ren Y, Zhu W, Ni T, Huang S, Zhang A, Zhang Y, Hua H, Jia Z, Sun Z
International immunopharmacology 2025 Oct 10;163:115236
International immunopharmacology 2025 Oct 10;163:115236
Monoclonal antibody SZ168 targeting Podoplanin alleviates neuroinflammation by suppressing microglial Pyroptosis in cerebral Hemorrhage.
Liu S, Cui J, Liang R, Wang X, Zhao Y
International immunopharmacology 2025 Oct 10;163:115201
International immunopharmacology 2025 Oct 10;163:115201
PACAP inhibits high fat-induced NLRP3 inflammasome-mediated pyroptosis in vascular endothelial cells by regulating the SIRT1/ROS pathway.
Dong J, Ma T, Qu Y, Ye R, Feng J, Bai G, Hong A, Ma Y
Molecular and cellular endocrinology 2025 Oct 1;608:112633
Molecular and cellular endocrinology 2025 Oct 1;608:112633
Targeting STING alleviates pyroptosis of bladder epithelial cells and ameliorates bladder fibrosis in neurogenic bladder.
Wang R, Wang M, Chen J, Sun M, Zhao P, Zheng X, Li D, Long C, Shen L, Wei G, Wu S
Biochemical pharmacology 2025 Nov;241:117177
Biochemical pharmacology 2025 Nov;241:117177
Activation of IRF2 signaling networks facilitates podocyte pyroptosis in lupus nephritis.
Zhang F, Xie Y, Dang RN, Yu J, Tian XX, Li LJ, Zhou QM, An XM, Chen PL, Luo YQ, Wu YS, Liu J, Zou HM
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):167990
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):167990
Traditional wisdom meets modern science: The protective role of sanhuang shu'ai decoction in ulcerative colitis models.
Zhang N, Liu A, Cao M, Han Z, Guo D, Zhang S, Zhang J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157163
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157163
Persistent Activation of Monocytes/Macrophages and Cell Senescence in SIV-Infected Macaques on ART.
Chen Y, Ding X, Ray S, Thirugnanam S, Blair R, Saied A, Sukhanov S, Kolls J, Kim WK, Delafontaine P, Rappaport J, Qin X, Rout N
bioRxiv : the preprint server for biology 2025 Nov 6;
bioRxiv : the preprint server for biology 2025 Nov 6;
Pulsed electromagnetic fields inhibit atherosclerosis by regulating pyroptosis through membrane tension-mediated mechanosensitive channels.
Cheng H, Zhang Q, Zhong W, Li H, Wang L, Wang S, He C, Fu C, Wei Q
Signal transduction and targeted therapy 2025 Nov 28;10(1):388
Signal transduction and targeted therapy 2025 Nov 28;10(1):388
Non-anticoagulant heparin alleviates myocardial ischemia-reperfusion injury through inhibiting GSDMD-mediated cardiomyocyte pyroptosis via the HMGB1/RAGE pathway.
Wang X, Liang Z, Liu M, Ouyang J, Gao P, Pan G
International immunopharmacology 2025 Nov 14;165:115412
International immunopharmacology 2025 Nov 14;165:115412
Repurposing of FDA-approved drugs by targeting SIRT2 to alleviate inflammatory response and kidney injury.
Huang HJ, Lin YC, Ho LJ, Su RY, Liu WC, Chiu HW
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2025 Nov 1;214:107296
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2025 Nov 1;214:107296
Calycosin Protects Against Chronic Prostatitis via Regulating Cellular Pyroptosis.
Wang H, Liu Z, Xu X, Zhang H, He L, Li M
American journal of reproductive immunology (New York, N.Y. : 1989) 2025 May;93(5):e70084
American journal of reproductive immunology (New York, N.Y. : 1989) 2025 May;93(5):e70084
Grafting of syringic acid onto fucoidan: Enhanced functional properties and therapeutic potential in histamine-induced liver injury.
Zhang M, Tang J, Wang J, Qi C, Chen G, Chen W, Wang C
Food research international (Ottawa, Ont.) 2025 May;208:116161
Food research international (Ottawa, Ont.) 2025 May;208:116161
IL-33 facilitates endoplasmic reticulum stress and pyroptosis in LPS-stimulated ARDS model in vitro.
Li PL, Fu HM, Liu K, Liu HF, Sui MZ, Yang JW
Molecular immunology 2025 May;181:102-112
Molecular immunology 2025 May;181:102-112
Deoxynivalenol-induced pyroptosis and autophagy inhibition collectively promote inflammatory injury in the glandular stomach of chicken embryos.
Chen F, Yang G, Qiu H, Gao S, Hou L, Dong J, Zhao P, Dong W
Poultry science 2025 May;104(5):105052
Poultry science 2025 May;104(5):105052
Human umbilical cord mesenchymal stem cell-derived exosomes repair IBD by activating the SIRT1-FXR pathway in macrophages.
Zhou M, Pei B, Cai P, Yi C, Akanyibah FA, Lyu C, Mao F
Stem cell research & therapy 2025 May 9;16(1):233
Stem cell research & therapy 2025 May 9;16(1):233
Aryl Hydrocarbon Receptor-Dependent miRNA-382-5p Mediates the Classical Pyroptosis Induced by Foodborne Benzo(a)pyrene through Targeting IκB in Liver.
Meng Y, Jia Y, He Z, Li J, Yuan L
Journal of agricultural and food chemistry 2025 May 28;73(21):12978-12992
Journal of agricultural and food chemistry 2025 May 28;73(21):12978-12992
Inhibition of NLRP3 Inflammasome Alleviates Postoperative Cognitive Impairment by Suppressing the HMGB-1/TLR4/NF-κB Pathway.
Ma G, Jiang X, Meng X, Liu Z, Ma X, Wang H
Neurochemical research 2025 May 28;50(3):173
Neurochemical research 2025 May 28;50(3):173
Icariin alleviates cardiomyocyte pyroptosis through AMPK-NLRP3 pathway to ameliorates diabetic cardiomyopathy.
Cai Z, Sun F, Wang Q, Li S, Wang L, Li H, Su Y, Yang H, Dong B
International immunopharmacology 2025 May 27;156:114690
International immunopharmacology 2025 May 27;156:114690
Thioredoxin-1 inhibits NLRP3-mediated pyroptosis by regulating TXNIP in models of Alzheimer's disease.
Jia J, Sheng Z, Zhang Y, Guo L, Chen Z, Zhu D, Zeng X, Liu H
Scientific reports 2025 May 13;15(1):16551
Scientific reports 2025 May 13;15(1):16551
p16INK4a Deletion Alleviated Obesity-Associated Kidney Fibrosis by Regulating Metabolic Reprogramming and the Inflammasome Pathway.
Liu Q, Wang F, Du Y, Liu Y, Zhang Z, Zhang X, Li J, Huang G, Liu F, Li B, Xiao W, Sui C, Bao N, Zhuang R, Gao C, Wang X, Gu X
Journal of cellular and molecular medicine 2025 Mar;29(5):e70444
Journal of cellular and molecular medicine 2025 Mar;29(5):e70444
Aerobic Exercise Affected Lymphocyte Apoptosis by Modulating ROS Release and NLRP3 Inflammasome Activation.
Lian X, Guo Z, Liu J, Zeng W
Bulletin of experimental biology and medicine 2025 Mar;178(5):685-690
Bulletin of experimental biology and medicine 2025 Mar;178(5):685-690
Exploring vestibulocerebellum-vestibular nuclei-spinal trigeminal nucleus causals communication and TRPV2 ion channel in a mouse model of vestibular migraine.
Zhai Q, Chen Q, Zhang N, Li H, Yu Q, Pan Y
The journal of headache and pain 2025 Mar 5;26(1):47
The journal of headache and pain 2025 Mar 5;26(1):47
Sinomenine alleviates neuroinflammation in chronic cerebral hypoperfusion by promoting M2 microglial polarization and inhibiting neuronal pyroptosis via exosomal miRNA-223-3p.
Yang Q, Chen Q, Zhang KB, Liu Y, Zheng JC, Hu DX, Luo J
Acta neuropathologica communications 2025 Mar 5;13(1):48
Acta neuropathologica communications 2025 Mar 5;13(1):48
Viral expression of NE/PPE enhances anti-colorectal cancer efficacy of oncolytic adenovirus by promoting TAM M1 polarization to reverse insufficient effector memory/effector CD8(+) T cell infiltration.
Wang S, Kong L, Wang L, Zhuang Y, Guo C, Zhang Y, Cui H, Gu X, Wu J, Jiang C
Journal of experimental & clinical cancer research : CR 2025 Mar 14;44(1):97
Journal of experimental & clinical cancer research : CR 2025 Mar 14;44(1):97
Decoding CKD-induced muscle atrophy through the critical role of lncRNA GAS5 and pyroptosis.
Huang R, Tang X, Liu S, Sun L
Molecular therapy. Nucleic acids 2025 Mar 11;36(1):102451
Molecular therapy. Nucleic acids 2025 Mar 11;36(1):102451
Blocking GATA6 Alleviates Pyroptosis and Inhibits Abdominal Wall Endometriosis Lesion Growth Through Inactivating the PI3K/AKT Pathway.
Du X, Yang H, Kang X, Fu C, Yang T
Cell biochemistry and biophysics 2025 Jun;83(2):1757-1770
Cell biochemistry and biophysics 2025 Jun;83(2):1757-1770
Leveraging the interconnected unfolded protein response and NLRP3 inflammasome pathways to reactivate Epstein-Barr virus in diffuse large B-cell lymphomas.
Xu H, Hutchinson TE, Koganti S, Rousseau BA, Xia D, McIntosh MT, Bhaduri-McIntosh S
NAR cancer 2025 Jun;7(2):zcaf017
NAR cancer 2025 Jun;7(2):zcaf017
Drug-free hyaluronic acid-microneedle with unexpected inhibition activity on benzalkonium chloride-induced corneal inflammation and stromal scarring.
Huang B, Zeng R, Liu X, Pan L, Bai H, Liao J, Xu W, Fu H, Nan K, Lin S
Materials today. Bio 2025 Jun;32:101722
Materials today. Bio 2025 Jun;32:101722
MicroRNA-9-3p inhibits endothelial pyroptosis in atherosclerosis by targeting the PTEN/AKT axis.
Wu Y, Ma Q, Meng X, Sun Q, Wang Z, Zhang W
International journal of biological macromolecules 2025 Jun;315(Pt 1):144289
International journal of biological macromolecules 2025 Jun;315(Pt 1):144289
Photobiomodulation regulates inflammation and autophagy in spinal cord injury through NLRP3/Caspase-1/IL-1β pathway by targeting TLR2.
Zuo X, Ju C, Zhang Z, Wei X, Ma Y, Song Z, Zhang J, Luo L, Zhu Z, Wang Z, Hu X
Molecular immunology 2025 Jun;182:1-10
Molecular immunology 2025 Jun;182:1-10
LncRNA MIR503HG regulates NETs-mediated NLRP3 inflammasome activation and NSCLC metastasis by enhancing the ubiquitination of C/EBPβ.
Ye X, Fang C, Hong W, Qian X, Yu B, Zhou B, Yao X, Chen D, Shu C, Luo C, Wang Y, Li Y
Clinical and translational medicine 2025 Jun;15(6):e70342
Clinical and translational medicine 2025 Jun;15(6):e70342
Pretreatment with Citrus reticulata 'Chachi' Polysaccharide Alleviates Alcohol-Induced Gastric Ulcer by Inhibiting NLRP3/ASC/Caspase-1 and Nrf2/HO-1 Signaling Pathways.
Liang H, Liang Y, Wu L, Lin L, Yao Y, Deng J, Xu J, Li H, Gao F, Xing W, Yu M, Jia X, Wei M, Li C, Zheng G
Nutrients 2025 Jun 20;17(13)
Nutrients 2025 Jun 20;17(13)
The non-structural protein of SFTSV activates NLRP1 and CARD8 inflammasome through disrupting the DPP9-mediated ternary complex.
Liu PP, Jiang SP, Li B, Gui WT, Qin XR, Yu XJ
PLoS pathogens 2025 Jul;21(7):e1013258
PLoS pathogens 2025 Jul;21(7):e1013258
Mechanism of hydroxychloroquine in the treatment of obstetric antiphospholipid syndrome by inhibiting NETs-induced trophoblast pyroptosis.
Liu J, Xu M, Shen D, Wang X
Molecular biology reports 2025 Jul 7;52(1):679
Molecular biology reports 2025 Jul 7;52(1):679
Ginsenoside Rg3 alleviates brain damage caused by chlorpyrifos exposure by targeting and regulating the microbial-gut-brain axis.
Liu S, Yang Y, Zong Y, Chen W, Geng J, Zhao Y, Du R, He Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156838
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156838
Antler base (Cervus nippon Temminck) peptides modulate the NLRP3 inflammatory pyroptosis and Nrf2/HO-1/NQO1 signaling pathways to ameliorate osteoarthritis: a structural and mechanistic study.
Sun S, Qiu H, Wang C, Zhang K, Zhao H, Zhao H, Shen Y, Wang Y, Zhang Y
Journal of ethnopharmacology 2025 Jul 24;351:120149
Journal of ethnopharmacology 2025 Jul 24;351:120149
Cornus officinalis loganin attenuates acute lung injury in mice via regulating the PI3K/AKT/NLRP3 axis.
Liu Y, Wang C, Hui T, Yuan Y, Chen S, Li Y, Wang G, Kang J, Xue X
Journal of ethnopharmacology 2025 Jul 24;351:120104
Journal of ethnopharmacology 2025 Jul 24;351:120104
Differences in macrophage pyroptosis and polarization induced by nano-/micro-calcium oxalate crystals.
Tong XY, Nong WJ, Tan RM, Ouyang JM
Journal of nanobiotechnology 2025 Jul 10;23(1):499
Journal of nanobiotechnology 2025 Jul 10;23(1):499
Comparison of the effects of Liraglutide, Tirzepatide, and Retatrutide on diabetic kidney disease in db/db mice.
Ma J, Hu X, Zhang W, Tao M, Wang M, Lu W
Endocrine 2025 Jan;87(1):159-169
Endocrine 2025 Jan;87(1):159-169
Highly BBB-permeable nanomedicine reverses neuroapoptosis and neuroinflammation to treat Alzheimer's disease.
Xie A, Cheng G, Wu J, Li Z, Yu G, Zhu X, Chen T
Biomaterials 2025 Jan;312:122749
Biomaterials 2025 Jan;312:122749
Tanreqing Injection Inhibits Activation of NLRP3 Inflammasome in Macrophages Infected with Influenza A Virus by Promoting Mitophagy.
Liu TY, Hao Y, Mao Q, Zhou N, Liu MH, Wu J, Wang Y, Yang MR
Chinese journal of integrative medicine 2025 Jan;31(1):19-27
Chinese journal of integrative medicine 2025 Jan;31(1):19-27
Xylo-oligosaccharides enhance intestinal and thymic immunity by modulating pyroptosis, gut microbiota, and Th17/Treg immune response in lipopolysaccharide-challenged piglets.
Sun W, Liu G, Shen F, Wu D, Lin Y, Zhang R, Che L, Feng B, Zhuo Y, Xu S, Hua L, Fang Z, Jiang X, Li J, Wang J
Journal of animal science 2025 Jan 4;103
Journal of animal science 2025 Jan 4;103
Neutrophil extracellular traps promote the activation of the NLRP3 inflammasome and PBMCs pyroptosis via the ROS-dependent signaling pathway in Kawasaki disease.
Jin J, Zhao Y, Fang Y, Pan Y, Wang P, Fan Z, Yu H
International immunopharmacology 2025 Jan 3;145:113783
International immunopharmacology 2025 Jan 3;145:113783
Mechanism of S100A9-mediated astrocyte activation via TLR4/NF-κB in Parkinson's disease.
Qiao CM, Tan LL, Ma XY, Xia YM, Li T, Li MA, Wu J, Nie X, Cui C, Zhao WJ, Shen YQ
International immunopharmacology 2025 Jan 27;146:113938
International immunopharmacology 2025 Jan 27;146:113938
Oridonin attenuates diabetic retinopathy progression by suppressing NLRP3 inflammasome pathway.
Zhang Y, Pan T, Yang Y, Xu X, Liu Y
Molecular and cellular endocrinology 2025 Jan 15;596:112419
Molecular and cellular endocrinology 2025 Jan 15;596:112419
Disrupted mitochondrial morphology and function exacerbate inflammation in elderly-onset ulcerative colitis.
Zhang M, Lv H, Bai X, Ruan G, Li Q, Lin K, Yang H, Qian J
Immunity & ageing : I & A 2025 Jan 10;22(1):4
Immunity & ageing : I & A 2025 Jan 10;22(1):4
Knockdown of Leucine-rich alpha-2-glycoprotein 1 alleviates renal ischemia-reperfusion injury by inhibiting NOX4-mediated apoptosis, inflammation, and oxidative stress.
Ye J, Qiu C, Zhang L
Experimental cell research 2025 Jan 1;444(1):114341
Experimental cell research 2025 Jan 1;444(1):114341
Functionalized Nanozyme Microcapsules Targeting Deafness Prevention via Mitochondrial Homeostasis Remodeling.
Ge S, Sun A, Zhou X, Niu P, Chen Y, Bao X, Yu M, Zhong Z, Sun J, Li G
Advanced materials (Deerfield Beach, Fla.) 2025 Feb;37(5):e2413371
Advanced materials (Deerfield Beach, Fla.) 2025 Feb;37(5):e2413371
Influence of the ERK/CHGB pathway in breast cancer progression under chronic stress.
Wang Y, Hou X, Wu Z, Ren J, Zhao Y
The international journal of biochemistry & cell biology 2025 Feb;179:106733
The international journal of biochemistry & cell biology 2025 Feb;179:106733
TRIM44 alleviates renal ischemia-reperfusion injury by inhibiting pyroptosis through the NLRP3 pathway.
Ning J, Wang J, Sun X, Li H, Cheng F
Molecular immunology 2025 Feb;178:20-31
Molecular immunology 2025 Feb;178:20-31
Porphyromonas gingivalis and Its Outer Membrane Vesicles Induce Neuroinflammation in Mice Through Distinct Mechanisms.
Qiu Y, Zhao Y, He G, Yang D
Immunity, inflammation and disease 2025 Feb;13(2):e70135
Immunity, inflammation and disease 2025 Feb;13(2):e70135
Structural Characterization and Anti-Gouty Nephropathy Potential of Polysaccharides from Atractylodes chinensis.
Chen X, Jia R, Zhang K, Sun S, Mei M, Zhao H, Shen Y, Wang Y, Zhang Y
Molecules (Basel, Switzerland) 2025 Feb 7;30(4)
Molecules (Basel, Switzerland) 2025 Feb 7;30(4)
Semen extender triggers a mild physiological inflammatory response in the uterus without disrupting sperm-uterine immune crosstalk in vitro in cattle.
Hulugalla M, Mansouri A, Waehama E, Akthar I, Miyamoto A
The Journal of reproduction and development 2025 Feb 5;71(1):24-34
The Journal of reproduction and development 2025 Feb 5;71(1):24-34
Jingui Shenqi Wan alleviates bone loss induced by primary osteoporosis by inhibiting osteoblast pyroptosis.
Qian Y, Yu Y, Yang F, Liang Q, Xu D, Chen J, Hu X
Journal of orthopaedic surgery and research 2025 Feb 5;20(1):141
Journal of orthopaedic surgery and research 2025 Feb 5;20(1):141
α-Cyperone Alleviates LPS-Induced Pyroptosis in Rat Aortic Endothelial Cells via the PI3K/AKT Signaling Pathway.
Liu S, Zhang Y, Liang X, Yin L, He C
Pharmaceuticals (Basel, Switzerland) 2025 Feb 22;18(3)
Pharmaceuticals (Basel, Switzerland) 2025 Feb 22;18(3)
The absence of IRG1 exacerbates bone loss in a mouse model of ovariectomy-induced osteoporosis by increasing osteoclastogenesis through the potentiation of NLRP3 inflammasome activation.
Wang F, Liu Y, Zhao Y, Zheng H, Zhang L
International immunopharmacology 2025 Feb 20;148:114099
International immunopharmacology 2025 Feb 20;148:114099
Integrated stress response-mediated metabolic reprogramming drives hepatic stellate cell activation and liver fibrosis via the noncanonical EIF3d-ATF4-S100P signaling pathway.
Yang S, Zhang H, Sun X, Chen Z, Nie Z, Li Y, Liu X, Kong Y, Wang Z, Zai W, Gao S, Chen W
Redox biology 2025 Dec;88:103905
Redox biology 2025 Dec;88:103905
Suvorexant attenuates cognitive impairment associated with circadian rhythm sleep-wake disorders by modulating microglia activation via the BMAL1/NLRP3 pathway.
Hu Y, Yun T, Hou D, Yang G
Experimental neurology 2025 Dec;394:115464
Experimental neurology 2025 Dec;394:115464
By inhibiting pyroptosis to reduce neuroinflammation, PEG-bHb may prevent the development of secondary injury after traumatic brain injury.
Zeng Q, You G, Li W, An J, Huang Z, Zhang X, Zhou H, Xiao Y, Wang Y, Zhao L
Experimental neurology 2025 Dec;394:115447
Experimental neurology 2025 Dec;394:115447
Cytosolic TOP3α facilitates mitochondrial DNA sensing by cGAS.
Cai D, Chen C, Meekrathok P, Zeng W, Wang Z, Peng Z, Mo Y, Xu X, Wang J, Qiu J
EMBO reports 2025 Dec;26(23):5959-5981
EMBO reports 2025 Dec;26(23):5959-5981
Fisetin carbon dots alleviate periodontitis by enhancing mitophagy through regulation of sirtuin 3 SUMOylation.
Deng Y, Jiang X, Che Z, Shang Y, Hu M, Wang W, Yu W, Yang B, Liu X
Journal of nanobiotechnology 2025 Dec 6;23(1):767
Journal of nanobiotechnology 2025 Dec 6;23(1):767
Activated oligoadenylate synthetase-ribonuclease L pathway promotes endothelial pyroptosis and impairs diabetic wound healing via thioredoxin-interacting protein m(6)A methylation.
Zhou P, Huang Y, Wang Z, Chen D, Long B, Qin P, Li Y, Yang C, Li Q
Molecular biomedicine 2025 Dec 29;6(1):150
Molecular biomedicine 2025 Dec 29;6(1):150
Integrating Network Pharmacology, Molecular Docking, and Experimental Validation: Andrographolide Attenuates Acute Liver Injury via the NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis Pathway.
Zhang Y, Liu S, Liang X, Yin L, He C
Biomolecules 2025 Dec 16;15(12)
Biomolecules 2025 Dec 16;15(12)
CD36-mediated fatty acid metabolic reprogramming activates synovial fibroblasts and promotes rheumatoid arthritis progression.
Hao J, Zheng J, Liu C, Lu J, Tan M, Li J, Mao J, Yu Y, Wang H, Zhang Y, Shen H
International immunopharmacology 2025 Dec 10;167:115594
International immunopharmacology 2025 Dec 10;167:115594
PML Is Limiting NLRP3 Inflammasome Activity in Human Endothelial Cells.
Liem CH, Steinemann G, Ghiroltean N, Yvonne Y, Sakr H, Nguyen H, Baum O, Berkholz J
Cells 2025 Dec 10;14(24)
Cells 2025 Dec 10;14(24)
miR-23a-5p Alleviates Gouty Inflammation by Targeting Interleukin-17A and Inhibiting NLR Family Pyrin Domain Containing 3 Inflammasome Activation.
Yuan X, Lin C, Zhang Y, He H, Li L
Archives of rheumatology 2025 Dec 1;40(4):443-451
Archives of rheumatology 2025 Dec 1;40(4):443-451
Inhibition of BRD4 alleviates pyroptosis induced by testicular ischemia/reperfusion injury through the NLRP3 pathway.
Wang J, Ning J, Zhou Z, Li H
Tissue & cell 2025 Aug;95:102919
Tissue & cell 2025 Aug;95:102919
Gegen Qinlian Decoction improves Alzheimer's disease through TLR4/NF-κB/NLRP3 pathway.
Zhang B, Chen L, Kang M, Ai L, Tao Y
Tissue & cell 2025 Aug;95:102818
Tissue & cell 2025 Aug;95:102818
Xuebijing inhibits alveolar macrophage M1 polarization by regulating ROS-mediated NLRP3 inflammasome signaling.
Chen X, Zhang F, Zhou Z, Jiang D, Wen L
In vitro cellular & developmental biology. Animal 2025 Aug;61(7):789-800
In vitro cellular & developmental biology. Animal 2025 Aug;61(7):789-800
Inhibiting NLRP3 Inflammasome Activation to Alleviate Retinal Inflammation and Protect the Optic Nerve of OPTN(E50K)Mice.
Wang S, Xiao R, Lu Y, Zhang Y, Zhang S, Liu X, Yuan H
Inflammation 2025 Aug;48(4):2105-2121
Inflammation 2025 Aug;48(4):2105-2121
Activation of pyroptosis impairs basal cell differentiation in the nasal epithelium in chronic rhinosinusitis with nasal polyps.
Zhang G, Jin S, Liu J, Du Y, Li Z, Liu L, Xu X, Wang Z, Yan S
Molecular medicine reports 2025 Aug;32(2)
Molecular medicine reports 2025 Aug;32(2)
P2X7 receptor is essential for ST36-attenuated cardiac fibrosis upon beta-adrenergic insult.
Zhang T, Lv J, Liu ZY, Lei QL, Jiang ZF, Sun XX, Yue X, Li X, Zhu KL, Yang YK, Luo L, Cao X
Purinergic signalling 2025 Aug;21(4):637-649
Purinergic signalling 2025 Aug;21(4):637-649
Spatiotemporal Immunomodulation of Macrophages via NLRP3/IL-1β Pathway by Core-Shell Microneedles to Promote Healing of Biofilm-Infected Diabetic Ulcers.
Yang Y, Chen N, Fan J, Fan L, Cai Y, Xue L, Chen S, Yang Z, An L, Cheng J, Ren T, Li Y
Small (Weinheim an der Bergstrasse, Germany) 2025 Aug;21(32):e2505179
Small (Weinheim an der Bergstrasse, Germany) 2025 Aug;21(32):e2505179
Cilostazol attenuates vascular inflammation via the regulation of TICAM1/IRF3 signaling pathway.
Chiu HW, Shih CC, Huang HJ, Huang TH, Sung LC
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Aug;189:118275
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Aug;189:118275
Carbon Monoxide Alleviates Cardiomyocyte Pyroptosis in Diabetic Cardiomyopathy by Downregulating the IL-33/ST2L Axis.
Jiang C, Zhu P, Yao P, Bi X, Gao C
Immunity, inflammation and disease 2025 Aug;13(8):e70231
Immunity, inflammation and disease 2025 Aug;13(8):e70231
Whey protein hydrolysate alleviated acetaminophen-induced hepatocyte pyroptosis by activating mitophagy.
Zhang S, Guo J, Liu M, Chen Y, Shen X, Wang J, Deng X, Guan S
Journal of dairy science 2025 Aug;108(8):7896-7911
Journal of dairy science 2025 Aug;108(8):7896-7911
HIIT and MICT mitigate endothelial dysfunction in early atherosclerotic mice via PCSK9 inhibition.
Liu G, Zhao B, Chen Q, Li X, Zhu X, Duan M, Zhang M, Liu Z, Wen X, Guo J, Zheng M, Wang R, Luo M
Scientific reports 2025 Aug 19;15(1):30411
Scientific reports 2025 Aug 19;15(1):30411
MiR-153 is Involved in Testicular Ischemia/Reperfusion Injury by Directly Targeting FOXO3 and Regulating Spermatogonia Pyroptosis.
Ning J, Wang J, Xu L, Li H
Molecular biotechnology 2025 Apr;67(4):1707-1719
Molecular biotechnology 2025 Apr;67(4):1707-1719
Schistosoma mansoni soluble egg antigen suppresses colorectal cancer growth in vitro and in vivo.
Pekkle Lam HY, Liang TR, Jiang SJ, Peng SY
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2025 Apr;58(2):241-250
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2025 Apr;58(2):241-250
WTAP Promotes Atherosclerosis by Inducing Macrophage Pyroptosis and M1 Polarization through Upregulating NLRP3.
Luo X, He C, Yang B, Yin S, Li K
Applied biochemistry and biotechnology 2025 Apr;197(4):2397-2416
Applied biochemistry and biotechnology 2025 Apr;197(4):2397-2416
PCSK9 Targeted Autophagosome-Tethering Compounds: Design, Synthesis, and Antiatherosclerosis Evaluation.
Wu H, Zhang Z, Xue Y, Guo J, Ouyang Z, Cao Z, Guo W, Zhang Q, Wang M, Gu X
Journal of medicinal chemistry 2025 Apr 24;68(8):8190-8207
Journal of medicinal chemistry 2025 Apr 24;68(8):8190-8207
Formononetin ameliorates depression-like behaviors through rebalancing microglia M1/M2 polarization and inhibiting NLRP3 inflammasome: involvement of activating PPARα-mediated autophagy.
Peng S, Su P, Liu L, Li Z, Liu Y, Tian L, Bai M, Xu E, Li Y
Molecular medicine (Cambridge, Mass.) 2025 Apr 24;31(1):153
Molecular medicine (Cambridge, Mass.) 2025 Apr 24;31(1):153
E3 ubiquitin ligase CHIP alleviates H/R-induced myocardial injury by inhibiting pyroptosis.
Hong L, Gong S, Zhang Q, Wang X, Fu Y
Molecular biology reports 2025 Apr 21;52(1):409
Molecular biology reports 2025 Apr 21;52(1):409
Card9 deficiency exacerbates vulvovaginal candidiasis by impairing the IL-17 production and vaginal epithelial barrier.
Liu W, Song Y, Wang R, Wan Z, Li R, Wang X
Medical mycology 2025 Apr 2;63(4)
Medical mycology 2025 Apr 2;63(4)
VEGF secreted by human dental pulp stem cell promotes spinal cord injury repair by inhibiting microglial pyroptosis through the PI3K/AKT pathway.
Zhang X, Liu T, Ma Z, Li G, Ding N, Wang Z, Guan Y, Zhang Y, Liu L, Chen X
Journal of translational medicine 2025 Apr 12;23(1):437
Journal of translational medicine 2025 Apr 12;23(1):437
Xuebijing improves inflammation and pyroptosis of acute lung injury by up-regulating miR-181d-5p-mediated SPP1 inactivation.
Wu X, Xin R, Zhang Y, Yang C, Sun F, Wang Y, Zheng F
Clinics (Sao Paulo, Brazil) 2024;79:100336
Clinics (Sao Paulo, Brazil) 2024;79:100336
25-hydroxycholesterol aggravates oxygen-glucose deprivation/reoxygenation-induced pyroptosis through promoting activation of NLRP3 inflammasome in H9C2 cardiomyocytes.
Jiang T, Li Y
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2024;57:e13299
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2024;57:e13299
M2 Macrophage-Derived Small Extracellular Vesicles Ameliorate Pyroptosis and Intervertebral Disc Degeneration.
Zhang K, Du L, Li Z, Huo Z, Shen L, Gao S, Jia Y, Zhu M, Xu B
Biomaterials research 2024;28:0047
Biomaterials research 2024;28:0047
Therapeutic potential of HUC-MSC-exos primed with IFN-γ against LPS-induced acute lung injury.
Wang C, Jiang C, Yang Y, Xi C, Yin Y, Wu H, Qian C
Iranian journal of basic medical sciences 2024;27(3):375-382
Iranian journal of basic medical sciences 2024;27(3):375-382
Cryptotanshinone Inhibits Bladder Cancer Cell Malignant Progression in a Lipopolysaccharide-Induced Inflammatory Microenvironment through NLRP3 Inhibition.
Tang C, Guo X, Li Y, Yi Y, Tang Z, Zhang Q, Luo B, Chen K, Liang K, Li G
Mediators of inflammation 2024;2024:8828367
Mediators of inflammation 2024;2024:8828367
Alkali burn injury model of meibomian gland dysfunction in mice.
Li Y, Yang YQ, Lin Y, Yan K, Lyu YF, Zhang ZQ, Huang CH, Hu JY, Liu ZG
International journal of ophthalmology 2024;17(12):2158-2166
International journal of ophthalmology 2024;17(12):2158-2166
Arctiin Alleviates Atopic Dermatitis Against Inflammation and Pyroptosis Through Suppressing TLR4/MyD88/NF-κB and NLRP3/Caspase-1/GSDMD Signaling Pathways.
Li J, Du X, Mu Z, Han X
Journal of inflammation research 2024;17:8009-8026
Journal of inflammation research 2024;17:8009-8026
The Onset of Systemic Lupus Erythematosus Triggers Nucleus Pulposus Cell Pyroptosis to Exacerbate Intervertebral Disc Degeneration.
Lao Z, Fang X, Shen S, Zhang Y, Chen X, Zhang H, Bian Y, Zhou C, Bao R, Xu T, Jin H, Fu F, Wu C, Hu C, Ruan H
Journal of inflammation research 2024;17:7705-7719
Journal of inflammation research 2024;17:7705-7719
The AGEs/RAGE Signaling Pathway Regulates NLRP3-Mediated Neuronal Pyroptosis After MCAO Injury in Lepr(-/-) Obese Rats.
Zhao L, Li S, Wang X, Zhang L, Zhang J, Liu X, Hu Y, Xian X, Zhang F, Li W, Zhang M
Journal of inflammation research 2024;17:6935-6954
Journal of inflammation research 2024;17:6935-6954
Identification and Validation of a Necroptosis-Related Prognostic Model in Tumor Recurrence and Tumor Immune Microenvironment in Breast Cancer Management.
Wang X, Chen Z, Tang J, Cao J
Journal of inflammation research 2024;17:5057-5076
Journal of inflammation research 2024;17:5057-5076
Lactobacillus Plantarum Promotes Wound Healing by Inhibiting the NLRP3 Inflammasome and Pyroptosis Activation in Diabetic Foot Wounds.
Wang X, Li X, Liu J, Tao Y, Wang T, Li L
Journal of inflammation research 2024;17:1707-1720
Journal of inflammation research 2024;17:1707-1720
"Dictionary of immune responses" reveals the critical role of monocytes and the core target IRF7 in intervertebral disc degeneration.
Xu P, Li K, Yuan J, Zhao J, Pan H, Pan C, Xiong W, Tan J, Li T, Huang G, Chen X, Miao X, He D, Cheng X
Frontiers in immunology 2024;15:1465126
Frontiers in immunology 2024;15:1465126
Spermidine attenuates chondrocyte inflammation and cellular pyroptosis through the AhR/NF-κB axis and the NLRP3/caspase-1/GSDMD pathway.
Guo X, Feng X, Yang Y, Zhang H, Bai L
Frontiers in immunology 2024;15:1462777
Frontiers in immunology 2024;15:1462777
KAE ameliorates LPS-mediated acute lung injury by inhibiting PANoptosis through the intracellular DNA-cGAS-STING axis.
Chen Y, Wu X, Jiang Z, Li X
Frontiers in pharmacology 2024;15:1461931
Frontiers in pharmacology 2024;15:1461931
(Pro)renin receptor aggravates myocardial pyroptosis in diabetic cardiomyopathy through AMPK-NLRP3 pathway.
Li S, Zhang J, Zhao Y, Kang L, Jie H, Dong B
Frontiers in pharmacology 2024;15:1453647
Frontiers in pharmacology 2024;15:1453647
TAK1 inhibition mitigates intracerebral hemorrhage-induced brain injury through reduction of oxidative stress and neuronal pyroptosis via the NRF2 signaling pathway.
Zhao J, Chen C, Ge L, Jiang Z, Hu Z, Yin L
Frontiers in immunology 2024;15:1386780
Frontiers in immunology 2024;15:1386780
Effect of Dl-3-n-Butylphthalide on olfaction in rotenone-induced Parkinson's rats.
Wang J, Li H, Wang C, Li D, Zhang Y, Shen M, Xu X, Wu T
Frontiers in neurology 2024;15:1367973
Frontiers in neurology 2024;15:1367973
Dexmedetomidine improves mitophagy and pyroptosis through the ALKBH5/FUNDC1 axis during epidural-related maternal fever.
Xiao F, Yao H, Qian J, Huang J, Xia G
Advances in medical sciences 2024 Sep;69(2):272-280
Advances in medical sciences 2024 Sep;69(2):272-280
The suppressive role of NLRP6 in host defense against Streptococcus suis infection.
Hu X, Lu Y, Yu X, Jia K, Xiong Q, Fang R
Veterinary microbiology 2024 Sep;296:110166
Veterinary microbiology 2024 Sep;296:110166
Dipsacoside B ameliorates cognitive impairment in sepsis-associated encephalopathy by reducing Th17 cell infiltration and neuroinflammation.
Peng S, Sun T, Yang D, Zhao H, Lin L, Xia B, Li M, Piao M, Shi Z, Tuo Q
Biochemical pharmacology 2024 Sep;227:116428
Biochemical pharmacology 2024 Sep;227:116428
Pseudorabies Virus UL4 protein promotes the ASC-dependent inflammasome activation and pyroptosis to exacerbate inflammation.
Zhang X, Chen G, Yin J, Nie L, Li L, Du Q, Tong D, Huang Y
PLoS pathogens 2024 Sep;20(9):e1012546
PLoS pathogens 2024 Sep;20(9):e1012546
Osteoclast-derived exosomes influence osteoblast differentiation in osteoporosis progression via the lncRNA AW011738/ miR-24-2-5p/ TREM1 axis.
Liu J, Wang B, Chen H, Yu X, Cao X, Zhang H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117231
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117231
Punicalagin Inhibits African Swine Fever Virus Replication by Targeting Early Viral Stages and Modulating Inflammatory Pathways.
Geng R, Yin D, Liu Y, Lv H, Zhou X, Bao C, Gong L, Shao H, Qian K, Chen H, Qin A
Veterinary sciences 2024 Sep 19;11(9)
Veterinary sciences 2024 Sep 19;11(9)
Helicobacter pylori CagA mediated mitophagy to attenuate the NLRP3 inflammasome activation and enhance the survival of infected cells.
Chen D, Wu L, Liu X, Wang Q, Gui S, Bao L, Wang Z, He X, Zhao Y, Zhou J, Xie Y
Scientific reports 2024 Sep 17;14(1):21648
Scientific reports 2024 Sep 17;14(1):21648
Trim31 deficiency exacerbates airway inflammation in asthma by enhancing the activation of the NLRP3 inflammasome.
Xue J, Jiang C, Chen X, Wang L
International immunopharmacology 2024 Sep 10;138:112591
International immunopharmacology 2024 Sep 10;138:112591
WTAP promotes fibroblast-like synoviocyte pyroptosis in Rheumatoid arthritis by upregulating N6-methyladenosine modification of NLRP3.
Liu X, Xia Z, Liu L, Ren D
Journal of bioenergetics and biomembranes 2024 Oct;56(5):563-571
Journal of bioenergetics and biomembranes 2024 Oct;56(5):563-571
Toll-Like Receptor 9 Aggravates Pulmonary Fibrosis by Promoting NLRP3-Mediated Pyroptosis of Alveolar Epithelial Cells.
Ren C, Wang Q, Fan S, Mi T, Zhang Z, He D
Inflammation 2024 Oct;47(5):1744-1761
Inflammation 2024 Oct;47(5):1744-1761
Ferulic Acid Interferes with Radioactive Intestinal Injury Through the DJ-1-Nrf2 and Sirt1-NF-κB-NLRP3 Pathways.
Zhang X, Zhang H, Huang M, Mei Y, Hu C, Huang C, Zhang H, Wei X, Gao Y, Ma Z
Molecules (Basel, Switzerland) 2024 Oct 26;29(21)
Molecules (Basel, Switzerland) 2024 Oct 26;29(21)
Hepatocyte-specific NR5A2 deficiency induces pyroptosis and exacerbates non-alcoholic steatohepatitis by downregulating ALDH1B1 expression.
Zhao R, Guo Z, Lu K, Chen Q, Riaz F, Zhou Y, Yang L, Cheng X, Wu L, Cheng K, Feng L, Liu S, Wu X, Zheng M, Yin C, Li D
Cell death & disease 2024 Oct 23;15(10):770
Cell death & disease 2024 Oct 23;15(10):770
LINC00365 promotes miR-221-5p to inhibit pyroptosis via Dicer in colorectal cancer.
Yang W, Huang X, Lv W, Jin Y, Zhu Y
Acta biochimica et biophysica Sinica 2024 Oct 22;57(4):529-541
Acta biochimica et biophysica Sinica 2024 Oct 22;57(4):529-541
Glutamine metabolism modulates microglial NLRP3 inflammasome activity through mitophagy in Alzheimer's disease.
Zhang Z, Li M, Li X, Feng Z, Luo G, Wang Y, Gao X
Journal of neuroinflammation 2024 Oct 15;21(1):261
Journal of neuroinflammation 2024 Oct 15;21(1):261
Role for NLRP3 inflammasome-mediated, Caspase1-dependent response in glaucomatous trabecular meshwork cell death and regulation of aqueous humor outflow.
Feng X, Chen Z, Cheng W, Liu C, Liu Q
Heliyon 2024 Oct 15;10(19):e38258
Heliyon 2024 Oct 15;10(19):e38258
Ulinastatin modulates NLRP3 inflammasome pathway in PTZ-induced epileptic mice: A potential mechanistic insight.
Wang H, Ma Y, Jin D, Yang X, Xu X
Heliyon 2024 Oct 15;10(19):e38050
Heliyon 2024 Oct 15;10(19):e38050
miRNA-193a-mediated WT1 suppression triggers podocyte injury through activation of the EZH2/β-catenin/NLRP3 pathway in children with diabetic nephropathy.
Wang P, Yang J, Dai S, Gao P, Qi Y, Zhao X, Liu J, Wang Y, Gao Y
Experimental cell research 2024 Oct 1;442(2):114238
Experimental cell research 2024 Oct 1;442(2):114238
Inhibition of BCAT1 expression improves recurrent miscarriage by regulating cellular dysfunction and inflammation of trophoblasts.
Xu G, Tian C, Li Y, Fang L, Wang J, Jing Z, Li S, Chen P
Cell and tissue research 2024 Nov;398(2):111-121
Cell and tissue research 2024 Nov;398(2):111-121
Polystyrene Microplastics Induce Injury to the Vascular Endothelial Through NLRP3-Mediated Pyroptosis.
Huo C, Zhu Y, Fang X, Cui J, Ye H, Zhao H, Ye L, Zhou L
Environmental toxicology 2024 Nov;39(11):5086-5098
Environmental toxicology 2024 Nov;39(11):5086-5098
Multifunctional Copper-Phenolic Nanopills Achieve Comprehensive Polyamines Depletion to Provoke Enhanced Pyroptosis and Cuproptosis for Cancer Immunotherapy.
Zhu G, Xie Y, Wang J, Wang M, Qian Y, Sun Q, Dai Y, Li C
Advanced materials (Deerfield Beach, Fla.) 2024 Nov;36(45):e2409066
Advanced materials (Deerfield Beach, Fla.) 2024 Nov;36(45):e2409066
Lycium barbarum polysaccharides (LBP) suppresses hypoxia/reoxygenation (H/R)-induced rat H9C2 cardiomyocytes pyroptosis via Nrf2/HO-1 signaling pathway.
Gao Y, Li H, Que Y, Chen W, Huang SY, Liu W, Ye X
International journal of biological macromolecules 2024 Nov;280(Pt 4):135924
International journal of biological macromolecules 2024 Nov;280(Pt 4):135924
HBSP inhibits tubular cell pyroptosis and apoptosis, promotes macrophage M2 polarization, and protects LPS-induced acute kidney injury.
Huang L, Wu Y, Sai W, Wang Y, Feng G, Lu Y, Chen F, Huang X, Zhao H, Gu Z, Yang B
Journal of cellular and molecular medicine 2024 Nov;28(22):e70202
Journal of cellular and molecular medicine 2024 Nov;28(22):e70202
Targeting GPR39 in structure-based drug discovery reduces Ang II-induced hypertension.
Hua D, Huang W, Xie Q, Xu W, Tang L, Liu M, Wu X, Zhang Q, Cao X, Li P, Sheng Y
Communications biology 2024 Nov 5;7(1):1441
Communications biology 2024 Nov 5;7(1):1441
GEFT inhibits the GSDM-mediated proptosis signalling pathway, promoting the progression and drug resistance of rhabdomyosarcoma.
Yang F, Xia T, Zhao Z, Lin J, Zhong L, Tang T, Liao D, Lai M, Ceng J, Meng L, Li F, Liu C
Cell death & disease 2024 Nov 30;15(11):867
Cell death & disease 2024 Nov 30;15(11):867
Ginsenoside Rg1 Alleviates Blood-Milk Barrier Disruption in Subclinical Bovine Mastitis by Regulating Oxidative Stress-Induced Excessive Autophagy.
Yang S, Fang Z, Duan H, Dong W, Xiao L
Antioxidants (Basel, Switzerland) 2024 Nov 24;13(12)
Antioxidants (Basel, Switzerland) 2024 Nov 24;13(12)
DsbA-L activates TGF-β1/SMAD3 signaling and M2 macrophage polarization by stimulating AKT1 and NLRP3 to promote pulmonary fibrosis.
Wang J, Xia Z, Qing B, Chen Y, Gu L, Chen H, Ge Z, Yuan Y
Molecular medicine (Cambridge, Mass.) 2024 Nov 23;30(1):228
Molecular medicine (Cambridge, Mass.) 2024 Nov 23;30(1):228
Paeoniflorin Inhibits the Activation of Microglia and Alleviates Depressive Behavior by Regulating SIRT1-NF-kB-NLRP3/Pyroptosis Pathway.
Wang X, Su L, Liu S, He Z, Li J, Zong Y, Chen W, Du R
International journal of molecular sciences 2024 Nov 22;25(23)
International journal of molecular sciences 2024 Nov 22;25(23)
Microplastics Exposure Aggravates Synovitis and Pyroptosis in SLE by Activating NF-κB and NRF2/KEAP1 Signaling.
Zeng W, He S, Zhao Y, Jiang M, Wang W, Yang L, Du W, Zhuang W
Toxics 2024 Nov 22;12(12)
Toxics 2024 Nov 22;12(12)
Insufficient FUNDC1-dependent mitophagy due to early environmental cadmium exposure triggers mitochondrial redox imbalance to aggravate diet-induced lipotoxicity.
Lian CY, Li HJ, Xia WH, Li Y, Zhou XL, Yang DB, Wan XM, Wang L
Environmental pollution (Barking, Essex : 1987) 2024 Nov 15;361:124724
Environmental pollution (Barking, Essex : 1987) 2024 Nov 15;361:124724
Inhibition of the FOXO1-ROCK1 axis mitigates cardiomyocyte injury under chronic hypoxia in Tetralogy of Fallot by maintaining mitochondrial quality control.
Ren C, Xi L, Li H, Pan Z, Li Y, Wang G, Dai J, He D, Fan S, Wang Q
Life sciences 2024 Nov 15;357:123084
Life sciences 2024 Nov 15;357:123084
Administration of USP7 inhibitor p22077 alleviates Angiotensin II (Ang II)-induced atrial fibrillation in Mice.
Wang Y, Gu YH, Ren KW, Xie X, Wang SH, Zhu XX, Wang L, Yang XL, Bi HL
Hypertension research : official journal of the Japanese Society of Hypertension 2024 May;47(5):1309-1322
Hypertension research : official journal of the Japanese Society of Hypertension 2024 May;47(5):1309-1322
Ampelopsin facilitates diabetic wound healing and keratinocyte cell progression by inhibiting the NLRP3 inflammasome pathway in macrophages.
Zhou Q, Cheng G
General physiology and biophysics 2024 May;43(3):185-196
General physiology and biophysics 2024 May;43(3):185-196
Supercritical CO(2) fluid extract from Stellariae Radix ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis by inhibit M1 macrophages polarization via AMPK activation.
Wu W, Song L, Wang H, Feng L, Li Z, Li Y, Li L, Peng L
Environmental toxicology 2024 May;39(5):3188-3197
Environmental toxicology 2024 May;39(5):3188-3197
Nattokinase attenuates endothelial inflammation through the activation of SRF and THBS1.
Chiu HW, Chou CL, Lee KT, Shih CC, Huang TH, Sung LC
International journal of biological macromolecules 2024 May;268(Pt 2):131779
International journal of biological macromolecules 2024 May;268(Pt 2):131779
Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis.
Liu T, Ma Z, Liu L, Pei Y, Wu Q, Xu S, Liu Y, Ding N, Guan Y, Zhang Y, Chen X
Neural regeneration research 2024 May;19(5):1105-1111
Neural regeneration research 2024 May;19(5):1105-1111
Chinese medicinal formula Fu Xin decoction against chronic heart failure by inhibiting the NLRP3/caspase-1/GSDMD pyroptotic pathway.
Zhang L, Li Y, Fan CD, Jiang YH, Sheng LS, Song XY, Lin YX, Xue YT, Sun R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116548
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116548
Platelet-rich plasma-derived extracellular vesicles inhibit NF-κB/NLRP3 pathway-mediated pyroptosis in intervertebral disc degeneration via the MALAT1/microRNA-217/SIRT1 axis.
Tao X, Xue F, Xu J, Wang W
Cellular signalling 2024 May;117:111106
Cellular signalling 2024 May;117:111106
ZAP facilitates NLRP3 inflammasome activation via promoting the oligomerization of NLRP3.
Qin D, Wang C, Yan R, Qin Y, Ying Z, Kong H, Zhao W, Zhang L, Song H
International immunopharmacology 2024 May 30;133:112123
International immunopharmacology 2024 May 30;133:112123
A potential virulence factor: Brucella flagellin FliK does not affect the main biological properties but inhibits the inflammatory response in RAW264.7 cells.
Zhai Y, Fang J, Zheng W, Hao M, Chen J, Liu X, Zhang M, Qi L, Zhou D, Liu W, Jin Y, Wang A
International immunopharmacology 2024 May 30;133:112119
International immunopharmacology 2024 May 30;133:112119
The role of FGF-21 in promoting diabetic wound healing by modulating high glucose-induced inflammation.
Li Z, Qiu X, Guan G, Shi K, Chen S, Tang J, Xiao M, Tang S, Yan Y, Zhou J, Xie H
Heliyon 2024 May 15;10(9):e30022
Heliyon 2024 May 15;10(9):e30022
Therapeutic Potential of Fucoidan in Alleviating Histamine-Induced Liver Injury: Insights from Mice Studies.
Zhang M, Liu H, Xu L, Zhang X, Chen W, Wang C
Foods (Basel, Switzerland) 2024 May 14;13(10)
Foods (Basel, Switzerland) 2024 May 14;13(10)
MSC-derived exosomal miR-140-3p improves cognitive dysfunction in sepsis-associated encephalopathy by HMGB1 and S-lactoylglutathione metabolism.
Ma Y, She X, Liu Y, Qin X
Communications biology 2024 May 11;7(1):562
Communications biology 2024 May 11;7(1):562
Salvianolic acid B attenuates diabetic nephropathy through alleviating ADORA2B, NALP3 in flammasome, and NFκB activity.
Wang Y, Chang J, Qiao S, Yang Y, Yun C, Li Y, Wang F
Canadian journal of physiology and pharmacology 2024 May 1;102(5):318-330
Canadian journal of physiology and pharmacology 2024 May 1;102(5):318-330
Pesticide avermectin-induced hepatotoxicity and growth inhibition in carp: Ameliorative capacity and potential mechanisms of quercetin as a dietary additive.
Xin Y, Li X, Ping K, Xiang Y, Li M, Li X, Yang H, Dong J
Aquatic toxicology (Amsterdam, Netherlands) 2024 Mar;268:106859
Aquatic toxicology (Amsterdam, Netherlands) 2024 Mar;268:106859
BRCC36 Deubiquitinates HMGCR to Regulate the Interplay Between Ferroptosis and Pyroptosis.
Wang H, Shu L, Lv C, Liu N, Long Y, Peng X, Ling H, Tao T, Tang J, Cheng Y, Liu S, Xiao D, Tao Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(11):e2304263
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(11):e2304263
Exogenous hydrogen sulfide ameliorates diabetes-associated cognitive dysfunction by regulating the nrf-2/HO-1 axis and the NLRP3 inflammasome pathway in diabetic rats.
Chen H, Sun H, Hua W, Chang H, Chen W, Ma S
European journal of pharmacology 2024 Mar 5;966:176344
European journal of pharmacology 2024 Mar 5;966:176344
Rutaecarpine protects podocytes in diabetic kidney disease by targeting VEGFR2/NLRP3-mediated pyroptosis.
Hu X, Wang J, Jiang L, Liu X, Ge Q, Wang Q, Qi X, Wu Y
International immunopharmacology 2024 Mar 30;130:111790
International immunopharmacology 2024 Mar 30;130:111790
VDR and deubiquitination control neuronal oxidative stress and microglial inflammation in Parkinson's disease.
Zheng Z, Chen M, Feng S, Zhao H, Qu T, Zhao X, Ruan Q, Li L, Guo J
Cell death discovery 2024 Mar 21;10(1):150
Cell death discovery 2024 Mar 21;10(1):150
Lactococcus garvieae exerts a critical role in inducing inflammation in dairy mastitis by triggering NLRP3 inflammasome-mediated pyroptosis in MAC-T cells.
Wu F, Du T, Jiang X, Liu S, Cheng Y, Zhang Z, Miao W, Wang T
World journal of microbiology & biotechnology 2024 Mar 12;40(4):132
World journal of microbiology & biotechnology 2024 Mar 12;40(4):132
Atrazine exposure promotes cardiomyocyte pyroptosis to exacerbate cardiotoxicity by activating NF-κB pathway.
Zhao X, Luo H, Yao S, Yang T, Fu F, Yue M, Ruan H
The Science of the total environment 2024 Mar 10;915:170028
The Science of the total environment 2024 Mar 10;915:170028
Cutting Edge: Cytosolic Receptor AIM2 Is Induced by Peroxisome Proliferator-activated Receptor γ following Mycobacterium tuberculosis Infection of Human Macrophages but Does Not Contribute to IL-1β Release.
Arnett E, Wolff J, Leopold Wager CM, Simper J, Badrak JL, Ontiveros CO, Ni B, Schlesinger LS
Journal of immunology (Baltimore, Md. : 1950) 2024 Mar 1;212(5):765-770
Journal of immunology (Baltimore, Md. : 1950) 2024 Mar 1;212(5):765-770
Interleukin-33/ST2 axis involvement in atrial remodeling and arrhythmogenesis.
Cheng TY, Chen YC, Li SJ, Lin FJ, Lu YY, Lee TI, Lee TW, Higa S, Kao YH, Chen YJ
Translational research : the journal of laboratory and clinical medicine 2024 Jun;268:1-12
Translational research : the journal of laboratory and clinical medicine 2024 Jun;268:1-12
Paeoniflorin alleviates depression by inhibiting the activation of NLRP3 inflammasome via promoting mitochondrial autophagy.
Su L, Guo P, Guo X, He Z, Zhao Y, Zong Y, Li J, Chen W, DU R
Chinese journal of natural medicines 2024 Jun;22(6):515-529
Chinese journal of natural medicines 2024 Jun;22(6):515-529
Bile acids induce liver fibrosis through the NLRP3 inflammasome pathway and the mechanism of FXR inhibition of NLRP3 activation.
Feng S, Xie X, Li J, Xu X, Chen C, Zou G, Lin G, Huang T, Hu R, Ran T, Han L, Zhang Q, Li Y, Zhao X
Hepatology international 2024 Jun;18(3):1040-1052
Hepatology international 2024 Jun;18(3):1040-1052
Bile acid metabolism is altered in learning and memory impairment induced by chronic lead exposure.
Liu A, Li Y, Li L, Chen K, Tan M, Zou F, Zhang X, Meng X
Journal of hazardous materials 2024 Jun 5;471:134360
Journal of hazardous materials 2024 Jun 5;471:134360
Revealing the Mechanism of NLRP3 Inflammatory Pathway Activation through K(+) Efflux Induced by PLO via Signal Point Mutations.
Shan Q, Ma W, Li B, Li Q, Wang X, Li Y, Wang J, Zhu Y, Liu N
International journal of molecular sciences 2024 Jun 18;25(12)
International journal of molecular sciences 2024 Jun 18;25(12)
Augmented microglial endoplasmic reticulum-mitochondria contacts mediate depression-like behavior in mice induced by chronic social defeat stress.
Zhang JR, Shen SY, Zhai MY, Shen ZQ, Li W, Liang LF, Yin SY, Han QQ, Li B, Zhang YQ, Yu J
Nature communications 2024 Jun 18;15(1):5199
Nature communications 2024 Jun 18;15(1):5199
MINK1 deficiency stimulates nucleus pulposus cell pyroptosis and exacerbates intervertebral disc degeneration.
Zhan K, Zhu K, Gu B, Yao S, Fu F, Zeng H, Tian K, Ji W, Jin H, Tong P, Wu C, Yue M, Ruan H
International immunopharmacology 2024 Jun 15;134:112202
International immunopharmacology 2024 Jun 15;134:112202
Trim27 aggravates airway inflammation and oxidative stress in asthmatic mice via potentiating the NLRP3 inflammasome.
Liu K, Gu Y, Gu S, Song L, Hua S, Li D, Tang M
International immunopharmacology 2024 Jun 15;134:112199
International immunopharmacology 2024 Jun 15;134:112199
Butyrate attenuates sympathetic activation in rats with chronic heart failure by inhibiting microglial inflammation in the paraventricular nucleus.
Liu C, Yu H, Xia H, Wang Z, Li B, Xue H, Jin S, Xiao L, Wu Y, Guo Q
Acta biochimica et biophysica Sinica 2024 Jun 11;56(12):1823-1832
Acta biochimica et biophysica Sinica 2024 Jun 11;56(12):1823-1832
miR-485-3p targets SIRT1 in vascular smooth muscle cells mediating the occurrence of aortic dissection.
Xie Y, Xie L, Qiu Z, He J, Jiang F, Cai M, Lin Y, Chen L
Journal of cellular and molecular medicine 2024 Jul;28(13):e18454
Journal of cellular and molecular medicine 2024 Jul;28(13):e18454
Long Non-coding RNA ZFAS1 Regulates Fibrosis and Scortosis in the Cell Model of Diabetic Nephropathy Through miR-525-5p/SGK1 Axis.
Zhuang L, Jin G, Wang Q, Ge X, Pei X
Applied biochemistry and biotechnology 2024 Jul;196(7):3731-3746
Applied biochemistry and biotechnology 2024 Jul;196(7):3731-3746
Modified Danzhi XiaoyaoSan inhibits neuroinflammation via regulating TRIM31/NLRP3 inflammasome in the treatment of CUMS depression.
Wang B, Tian L, Wu M, Zhang D, Yan X, Bai M, Li Y, Su P, Xu E
Experimental gerontology 2024 Jul;192:112451
Experimental gerontology 2024 Jul;192:112451
Adiponectin inhibits ROS/NLRP3 inflammatory pathway through FOXO3A to ameliorate oral submucosal fibrosis.
Zeng Y, Luo M, Yao Z, Xiao X
Odontology 2024 Jul;112(3):811-825
Odontology 2024 Jul;112(3):811-825
4-Octyl itaconate inhibits inflammation via the NLRP3 pathway in neuromyelitis optica spectrum disorders.
Li T, Li JW, Qin YH, Liu R, Xu XN, Li X, Li LM, Feng B, Yang L, Yang CS
Annals of clinical and translational neurology 2024 Jul;11(7):1732-1749
Annals of clinical and translational neurology 2024 Jul;11(7):1732-1749
Glycolytic enzyme PGK1 promotes M1 macrophage polarization and induces pyroptosis of acute lung injury via regulation of NLRP3.
Zhu G, Yu H, Peng T, Yang K, Xu X, Gu W
Respiratory research 2024 Jul 30;25(1):291
Respiratory research 2024 Jul 30;25(1):291
Baicalin and probenecid protect against Glaesserella parasuis challenge in a piglet model.
Fu S, Liu S, Li J, Dong Q, Fu Y, Luo R, Sun Y, Tian X, Liu W, Zong B, Ye C, Lu Q, Qiu Y, Guo L
Veterinary research 2024 Jul 29;55(1):96
Veterinary research 2024 Jul 29;55(1):96
The downregulation of SCGN induced by lipotoxicity promotes NLRP3-mediated β-cell pyroptosis.
Ouyang S, Xiang S, Wang X, Yang X, Liu X, Zhang M, Zhou Y, Xiao Y, Zhou L, Fan G, Yang J
Cell death discovery 2024 Jul 27;10(1):340
Cell death discovery 2024 Jul 27;10(1):340
Acceleration of bone repairation by BMSCs overexpressing NGF combined with NSA and allograft bone scaffolds.
Ji Y, Mao Y, Lin H, Wang Y, Zhao P, Guo Y, Gu L, Fu C, Chen X, Lv Z, Wang N, Li Q, Bei C
Stem cell research & therapy 2024 Jul 2;15(1):194
Stem cell research & therapy 2024 Jul 2;15(1):194
Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication.
Ming S, Zhang S, Xing J, Yang G, Zeng L, Wang J, Chu B
iScience 2024 Jul 19;27(7):110144
iScience 2024 Jul 19;27(7):110144
ZIF-8-based Nanoparticles for Inflammation Treatment and Oxidative Stress Reduction in Periodontitis.
Li Y, Xu C, Mao J, Mao L, Li W, Liu Z, Shin A, Wu J, Hou L, Li D, Lin K, Liu J
ACS applied materials & interfaces 2024 Jul 17;16(28):36077-36094
ACS applied materials & interfaces 2024 Jul 17;16(28):36077-36094
NADase CD38 is a key determinant of ovarian aging.
Yang Q, Chen W, Cong L, Wang M, Li H, Wang H, Luo X, Zhu J, Zeng X, Zhu Z, Xu Y, Lei M, Zhao Y, Wei C, Sun Y
Nature aging 2024 Jan;4(1):110-128
Nature aging 2024 Jan;4(1):110-128
Empagliflozin reduces endoplasmic reticulum stress associated TXNIP/NLRP3 activation in tunicamycin-stimulated aortic endothelial cells.
Campeau MA, Leask RL
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jan;397(1):267-279
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jan;397(1):267-279
GAS6 attenuates sepsis-induced cardiac dysfunction through NLRP3 inflammasome-dependent mechanism.
Ji T, Liu Q, Yu L, Lei W, Lu C, Chen J, Xie X, Zhang Z, Liang Z, Deng C, Chen Y, Ren J, Yang Y
Free radical biology & medicine 2024 Jan;210:195-211
Free radical biology & medicine 2024 Jan;210:195-211
Extracellular ATP (eATP) inhibits the progression of endometriosis and enhances the immune function of macrophages.
Zhou L, Cai E, Liu H, Cheng H, Ye X, Zhu H, Chang X
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166895
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166895
Brassisterol A, a new ergosterol from co-cultivation of fungi attenuates neuroinflammation via targeting NLRP3/caspase-1/GSDMD pathway.
Tong Z, Kong L, Zhang Y, Hu T, Dai R, Wang Y, Ji J, Huang Z, Hu L
Bioorganic chemistry 2024 Jan;142:106955
Bioorganic chemistry 2024 Jan;142:106955
Bacteroides fragilis alleviates necrotizing enterocolitis through restoring bile acid metabolism balance using bile salt hydrolase and inhibiting FXR-NLRP3 signaling pathway.
Chen Z, Chen H, Huang W, Guo X, Yu L, Shan J, Deng X, Liu J, Li W, Shen W, Fan H
Gut microbes 2024 Jan-Dec;16(1):2379566
Gut microbes 2024 Jan-Dec;16(1):2379566
Weizmannia coagulans BCF-01: a novel gastrogenic probiotic for Helicobacter pylori infection control.
Chen Z, Tang Z, Li W, Deng X, Yu L, Yang J, Liu J, Cheng Y, Huang W, Guo X, Shan J, Zhou D, Zeng W, Bai Y, Fan H
Gut microbes 2024 Jan-Dec;16(1):2313770
Gut microbes 2024 Jan-Dec;16(1):2313770
Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress.
Liu C, Xu Y, Yang G, Tao Y, Chang J, Wang S, Cheung TH, Chen J, Zeng YA
Cell stem cell 2024 Jan 4;31(1):89-105.e6
Cell stem cell 2024 Jan 4;31(1):89-105.e6
Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Ameliorate Aging-Induced BTB Impairment in Porcine Testes by Activating Autophagy and Inhibiting ROS/NLRP3 Inflammasomes via the AMPK/mTOR Signaling Pathway.
Zhou Y, Yan J, Qiao L, Zeng J, Cao F, Sheng X, Qi X, Long C, Liu B, Wang X, Yao H, Xiao L
Antioxidants (Basel, Switzerland) 2024 Jan 31;13(2)
Antioxidants (Basel, Switzerland) 2024 Jan 31;13(2)
Colchicine ameliorates myocardial injury induced by coronary microembolization through suppressing pyroptosis via the AMPK/SIRT1/NLRP3 signaling pathway.
Li H, Yang H, Qin Z, Wang Q, Li L
BMC cardiovascular disorders 2024 Jan 3;24(1):23
BMC cardiovascular disorders 2024 Jan 3;24(1):23
Knockdown of ChREBP ameliorates retinal microvascular endothelial cell injury and angiogenic responses in diabetic retinopathy.
Sui Y, Du C, Wang M, Liu X, Chai Q, Liang S, Ma J, Duan J
Biochemical and biophysical research communications 2024 Jan 29;694:149389
Biochemical and biophysical research communications 2024 Jan 29;694:149389
Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.
Zhang B, He Z, Guo J, Li F, Huang Z, Zheng W, Xing W, Li M, Zhu Y, Yang X
Aging 2024 Jan 26;16(2):1145-1160
Aging 2024 Jan 26;16(2):1145-1160
Carvedilol induces pyroptosis through NLRP3-caspase1-ASC inflammasome by nuclear migration of NF-κB in prostate cancer models.
Zeng Y, Li MX, Wu SQ, Xu C
Molecular biology reports 2024 Jan 25;51(1):201
Molecular biology reports 2024 Jan 25;51(1):201
Endoplasmic reticulum aminopeptidase 2 regulates CD4(+) T cells pyroptosis in rheumatoid arthritis.
Zhang J, Cai H, Sun W, Wu W, Nan Y, Ni Y, Wu X, Chen M, Xu H, Wang Y
Arthritis research & therapy 2024 Jan 25;26(1):36
Arthritis research & therapy 2024 Jan 25;26(1):36
Rutin prevents pyroptosis and M1 microglia via Nrf2/Mac-1/caspase-1-mediated inflammasome axis to improve POCD.
Ji Y, Ma Y, Ma Y, Wang Y, Zhao X, Jin D, Xu L, Ge S
International immunopharmacology 2024 Jan 25;127:111290
International immunopharmacology 2024 Jan 25;127:111290
Targeted Degradation of PCSK9 In Vivo by Autophagy-Tethering Compounds.
Ouyang Z, Ma M, Zhang Z, Wu H, Xue Y, Jian Y, Yin K, Yu S, Zhao C, Guo W, Gu X
Journal of medicinal chemistry 2024 Jan 11;67(1):433-449
Journal of medicinal chemistry 2024 Jan 11;67(1):433-449
VSIG4 ameliorates intestinal inflammation through inhibiting macrophages NLRP3 inflammasome and pyroptosis.
Liao Y, Deng C, Wang X
Tissue & cell 2024 Feb;86:102285
Tissue & cell 2024 Feb;86:102285
4-octyl itaconate ameliorates ventilator-induced lung injury.
Wang X, Kong W, Yang R, Yang C
Archives of biochemistry and biophysics 2024 Feb;752:109853
Archives of biochemistry and biophysics 2024 Feb;752:109853
Investigating the TLR4/TAK1/IRF7 axis in NLRP3-Mediated Pyroptosis in Parkinson's Disease.
Quan W, Liu Y, Li J, Chen D, Xu J, Song J, Chen J, Sun S
Inflammation 2024 Feb;47(1):404-420
Inflammation 2024 Feb;47(1):404-420
Methane-Rich Saline Suppresses ER-Mitochondria Contact and Activation of the NLRP3 Inflammasome by Regulating the PERK Signaling Pathway to Ameliorate Intestinal Ischemia‒Reperfusion Injury.
Li Z, Wang B, Tian L, Zheng B, Zhao X, Liu R
Inflammation 2024 Feb;47(1):376-389
Inflammation 2024 Feb;47(1):376-389
Serabelisib regulates GSDMD-mediated pyroptosis, apoptosis and migration of hepatoma cells via the PI3K/Akt/E-cadherin signaling pathway.
Li M, Huang Z, Zhou Y
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 Feb;33(2):171-181
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 Feb;33(2):171-181
Sodium-glucose co-transporter 2 inhibitor canagliflozin modulates myocardial metabolism and inflammation in a swine model for chronic myocardial ischemia.
Harris DD, Sabe SA, Xu CM, Sabra M, Broadwin M, Malhotra A, Li JW, Abid MR, Sellke FW
Surgery 2024 Feb;175(2):265-270
Surgery 2024 Feb;175(2):265-270
ALOX5 drives the pyroptosis of CD4(+) T cells and tissue inflammation in rheumatoid arthritis.
Cai H, Zhang J, Xu H, Sun W, Wu W, Dong C, Zhou P, Xue C, Nan Y, Ni Y, Wu X, Gu Z, Chen M, Wang Y
Science signaling 2024 Feb 27;17(825):eadh1178
Science signaling 2024 Feb 27;17(825):eadh1178
PPAR γ activation in chondrocytes alleviates glucocorticoid-induced oxidative stress, mitochondrial impairment, and pyroptosis via autophagic flow enhancement.
Wu D, Shen Z, Gou Y, Yu T, Hong J, Wang Y, Ni F, Qiqige N, Lu H, Xue E
Chemico-biological interactions 2024 Feb 25;390:110877
Chemico-biological interactions 2024 Feb 25;390:110877
Baicalin attenuates lipopolysaccharide-induced intestinal inflammatory injury via suppressing PARP1-mediated NF-κB and NLRP3 signalling pathway.
Lu Q, Wang N, Wen D, Guo P, Liu Y, Fu S, Ye C, Wu Z, Qiu Y
Toxicon : official journal of the International Society on Toxinology 2024 Feb 23;239:107612
Toxicon : official journal of the International Society on Toxinology 2024 Feb 23;239:107612
Isofraxidin attenuates dextran sulfate sodium-induced ulcerative colitis through inhibiting pyroptosis by upregulating Nrf2 and reducing reactive oxidative species.
He S, Zhang T, Wang YY, Yuan W, Li L, Li J, Yang YY, Wu DM, Xu Y
International immunopharmacology 2024 Feb 15;128:111570
International immunopharmacology 2024 Feb 15;128:111570
An Amino Acids and Dipeptide Injection Inhibits the TNF-α/HMGB1 Inflammatory Signaling Pathway to Reduce Pyroptosis and M1 Microglial Polarization in POCD Mice: the Gut to the Brain.
Ji Y, Ma Y, Ma Y, Wang Y, Zhao X, Xu L, Ge S
Molecular neurobiology 2024 Dec;61(12):10097-10114
Molecular neurobiology 2024 Dec;61(12):10097-10114
Shikonin from lithospermum erythrorhizon induces pyroptosis in trophoblast cells by activating the CTSB-NLRP3 inflammasome.
Zeng F, Lai Y, Huang Y, Zhu F, Gao J, Chen Z, Zeng L, Feng M, Qiu P, Yuan S, Deng G
Annals of medicine 2024 Dec;56(1):2394584
Annals of medicine 2024 Dec;56(1):2394584
Mesenchymal stem cell-loaded hydrogel to inhibit inflammatory reaction in surgical brain injury via mitochondria transfer.
Wang Y, Yang X, Liu M, Yan Y, Kong F, Wang J, Zhang Z, Chen Y, Chen L, Liang Z, Peng X, Liu F
Journal of controlled release : official journal of the Controlled Release Society 2024 Dec;376:231-240
Journal of controlled release : official journal of the Controlled Release Society 2024 Dec;376:231-240
Y9, a Gboxin analog, displays anti-tumor effect in non-small cell lung cancer by inducing lysosomal dysfunction and apoptosis.
Yin J, Ding L, Yao S, Huang J, Xiao Y, Wang Y, Zhang B, Rehmutulla M, Gu L, Tong Q, Zhang Y
Bioorganic chemistry 2024 Dec;153:107820
Bioorganic chemistry 2024 Dec;153:107820
Jianwei Shoutai Pills alleviates miscarriage by modulating gut microbial production of BAs and NLRP3-inflammasome at the maternal-fetal interface of rats.
Chen S, Xue X, Zhang H, Huang X, Lin X, He J, Chen L, Luo S, Gao J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156000
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156000
Xiaoyaosan against depression through suppressing LPS mediated TLR4/NLRP3 signaling pathway in "microbiota-gut-brain" axis.
Liu X, Liu H, Wu X, Zhao Z, Wang S, Wang H, Qin X
Journal of ethnopharmacology 2024 Dec 5;335:118683
Journal of ethnopharmacology 2024 Dec 5;335:118683
Mammary hydroxylated oestrogen activates the NLRP3 inflammasome in tumor-associated macrophages to promote breast cancer progression and metastasis.
Zhao H, Xu J, Zhong Y, He S, Hao Z, Zhang B, Liu Z, Zhou X
International immunopharmacology 2024 Dec 5;142(Pt A):113034
International immunopharmacology 2024 Dec 5;142(Pt A):113034
Kaempferol improves depression-like behaviors through shifting microglia polarization and suppressing NLRP3 via tilting the balance of PPARγ and STAT1 signaling.
Su P, Liu L, Gong Y, Peng S, Yan X, Bai M, Xu E, Li Y
International immunopharmacology 2024 Dec 25;143(Pt 3):113538
International immunopharmacology 2024 Dec 25;143(Pt 3):113538
HDAC10 switches NLRP3 modification from acetylation to ubiquitination and attenuates acute inflammatory diseases.
Yang M, Qin Z, Lin Y, Ma D, Sun C, Xuan H, Cui X, Ma W, Zhu X, Han L
Cell communication and signaling : CCS 2024 Dec 20;22(1):615
Cell communication and signaling : CCS 2024 Dec 20;22(1):615
Astragaloside IV attenuates podocyte apoptosis via regulating TXNIP/NLRP3/GSDMD signaling pathway in diabetic nephropathy.
Hu Z, Zhou Y, Gao C, Liu J, Pan C, Guo J
Diabetology & metabolic syndrome 2024 Dec 18;16(1):296
Diabetology & metabolic syndrome 2024 Dec 18;16(1):296
Role of AhR-Hsp90-MDM2-mediated VDR ubiquitination in PM2.5-induced renal toxicity.
Zhang P, Wang L, Zhang J, An Q, Wang Y, Hu N, Pu D, He L, Huang J
Environmental research 2024 Dec 15;263(Pt 2):120174
Environmental research 2024 Dec 15;263(Pt 2):120174
Comparison of Endoplasmic Reticulum Stress and Pyroptosis Induced by Pathogenic Calcium Oxalate Monohydrate and Physiologic Calcium Oxalate Dihydrate Crystals in HK-2 Cells: Insights into Kidney Stone Formation.
Nong WJ, Tong XY, Ouyang JM
Cells 2024 Dec 15;13(24)
Cells 2024 Dec 15;13(24)
The molecular mechanisms by which the NLRP3 inflammasome regulates blood-brain barrier permeability following cryptococcal meningitis.
Liu L, Tang Y, Zhang L, Huang P, Li X, Xiao Y, Mao D, Liu L, Xiong J
Heliyon 2024 Dec 15;10(23):e39653
Heliyon 2024 Dec 15;10(23):e39653
Exosomes from human bone marrow MSCs alleviate PD-1/PD-L1 inhibitor-induced myocardial injury in melanoma mice by regulating macrophage polarization and pyroptosis.
Zhou B, Qin Q, Fang Y, Liu X, Zhang M, Wang S, Zhong L, Guo R
Life sciences 2024 Dec 1;358:123108
Life sciences 2024 Dec 1;358:123108
TRPM7 contributes to pyroptosis and its involvement in status epilepticus.
Tong X, Tong Y, Zheng J, Shi R, Liang H, Li M, Meng Y, Shi J, Zhao D, Seehus CR, Wang J, Xu X, Boczek T, Suzuki S, Fleig A, Penner R, Zhang N, Xu J, Duan J, Yu Z, Wang W, Zhao W, Guo F
Journal of neuroinflammation 2024 Dec 1;21(1):315
Journal of neuroinflammation 2024 Dec 1;21(1):315
Autocatalytic, Brain Tumor-Targeting Delivery of Bardoxolone Methyl Self-Assembled Nanoparticles for Glioblastoma Treatment.
Ye Z, Sheu WC, Qu H, Peng B, Liu J, Zhang L, Yuan F, Wei Y, Zhou J, Chen Q, Xiao X, Zhang S
Small science 2024 Aug;4(8):2400081
Small science 2024 Aug;4(8):2400081
1,8-cineole ameliorates experimental diabetic angiopathy by inhibiting NLRP3 inflammasome-mediated pyroptosis in HUVECs via SIRT2.
Zhang J, Li X, Cui W, Lu D, Zhang Y, Liao J, Guo L, Jiao C, Tao L, Xu Y, Shen X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117085
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117085
Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling.
Chen W, Yang KB, Zhang YZ, Lin ZS, Chen JW, Qi SF, Wu CF, Feng GK, Yang DJ, Chen M, Zhu XF, Li X
Journal of experimental & clinical cancer research : CR 2024 Aug 30;43(1):248
Journal of experimental & clinical cancer research : CR 2024 Aug 30;43(1):248
Reactive Oxygen Species-Responsive Nanoparticle Delivery of Small Interfering Ribonucleic Acid Targeting Olfactory Receptor 2 for Atherosclerosis Theranostics.
Ni H, Zhou H, Liang X, Ge Y, Chen H, Liu J, Wang B, Chen H, Zhang Y, Luo S, Chen Y, Lu X, Yin C, Fan Q
ACS nano 2024 Aug 27;18(34):23599-23614
ACS nano 2024 Aug 27;18(34):23599-23614
Inhibition of aquaporin-9 ameliorates severe acute pancreatitis and associated lung injury by NLRP3 and Nrf2/HO-1 pathways.
Chen J, Zhu X, Wang Z, Rützler M, Lu Q, Xu H, Andersson R, Dai Y, Shen Z, Calamita G, Xie S, Bai Y, Chen B
International immunopharmacology 2024 Aug 20;137:112450
International immunopharmacology 2024 Aug 20;137:112450
SGK3 deficiency in macrophages suppresses angiotensin II-induced cardiac remodeling via regulating Ndufa13-mediated mitochondrial oxidative stress.
Ren J, Che Y, Li H, Gao H, Wang Y, Wang Y, Su H, Li Z, Li J, Qu P
Cellular and molecular life sciences : CMLS 2024 Aug 19;81(1):359
Cellular and molecular life sciences : CMLS 2024 Aug 19;81(1):359
Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead.
Xie X, Wang K, Shen X, Li X, Wang S, Yuan S, Li B, Wang Z
Journal of hazardous materials 2024 Aug 15;475:134854
Journal of hazardous materials 2024 Aug 15;475:134854
STAT4-Mediated Klotho Up-Regulation Contributes to the Brain Ischemic Tolerance by Cerebral Ischemic Preconditioning via Inhibiting Neuronal Pyroptosis.
Liu XY, Zhang LY, Wang XY, Li SC, Hu YY, Zhang JG, Xian XH, Li WB, Zhang M
Molecular neurobiology 2024 Apr;61(4):2336-2356
Molecular neurobiology 2024 Apr;61(4):2336-2356
NLRP3 Inflammasome-dependent Pathway is Involved in the Pathogenesis of Polycystic Ovary Syndrome.
Wang B, Shi M, Yu C, Pan H, Shen H, Du Y, Zhang Y, Liu B, Xi D, Sheng J, Huang H, Ding G
Reproductive sciences (Thousand Oaks, Calif.) 2024 Apr;31(4):1017-1027
Reproductive sciences (Thousand Oaks, Calif.) 2024 Apr;31(4):1017-1027
M1 polarization of macrophages promotes stress-induced hair loss via interleukin-18 and interleukin-1β.
Xiao X, Gao Y, Yan L, Deng C, Wu W, Lu X, Lu Q, Zhong W, Xu Y, Zhang C, Chen W, Huang B
Journal of cellular physiology 2024 Apr;239(4):e31181
Journal of cellular physiology 2024 Apr;239(4):e31181
SARS-CoV-2 virus-like particle variants alpha and delta mimic the native viruses in their differential inflammasome activating potential.
Bandyszewska M, Ambrożek-Latecka M, Hoser G, Grzanka M, Hornung F, Deinhardt-Emmer S, Skirecki T
Antiviral research 2024 Apr;224:105857
Antiviral research 2024 Apr;224:105857
Intestinal metabolite UroB alleviates cerebral ischemia/reperfusion injury by promoting competition between TRIM65 and TXNIP for binding to NLRP3 inflammasome in response to neuroinflammation.
Luo J, Luo Y, Chen J, Gao Y, Tan J, Yang Y, Yang C, Jiang N, Luo Y
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167056
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167056
Mycobacterium tuberculosis PE_PGRS38 Enhances Intracellular Survival of Mycobacteria by Inhibiting TLR4/NF-κB-Dependent Inflammation and Apoptosis of the Host.
Ullah H, Shi X, Taj A, Cheng L, Yan Q, Sha S, Ahmad, Kang J, Haris M, Ma X, Ma Y
Biology 2024 Apr 30;13(5)
Biology 2024 Apr 30;13(5)
The prevention effect of pulsed electromagnetic fields treatment on senile osteoporosis in vivo via improving the inflammatory bone microenvironment.
Zhou J, Jia F, Qu M, Ning P, Huang X, Tan L, Liu D, Zhong P, Wu Q
Electromagnetic biology and medicine 2024 Apr 2;43(1-2):46-60
Electromagnetic biology and medicine 2024 Apr 2;43(1-2):46-60
Preliminary investigation into the impact of BPA on osteoblast activity and bone development: In vitro and in vivo models.
Shi X, Wu K, Liu C, Cao K, Zhang Q, Wu W, Luo C, Huang W
Environmental pollution (Barking, Essex : 1987) 2024 Apr 15;347:123731
Environmental pollution (Barking, Essex : 1987) 2024 Apr 15;347:123731
LncRNA GAS5 restrains ISO-induced cardiac fibrosis by modulating mir-217 regulation of SIRT1.
Zhang YH, Sun TT, Liu ZH, Li X, Fan XF, Han LP
Scientific reports 2024 Apr 1;14(1):7652
Scientific reports 2024 Apr 1;14(1):7652
Role and significance of SIRT1 in regulating the LPS-activated pyroptosis pathway in children with congenital hydronephrosis.
Wang Z, Weizhong G, Zhou J, Tang D
World journal of pediatric surgery 2023;6(4):e000602
World journal of pediatric surgery 2023;6(4):e000602
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Linghu L, Zong W, Liao Y, Chen Q, Meng F, Wang G, Liao Z, Lan X, Chen M
Research (Washington, D.C.) 2023;6:0276
Research (Washington, D.C.) 2023;6:0276
Astragaloside IV Attenuates High-Glucose-Induced Impairment in Diabetic Nephropathy by Increasing Klotho Expression via the NF-κB/NLRP3 Axis.
He J, Cui J, Shi Y, Wang T, Xin J, Li Y, Shan X, Zhu Z, Gao Y
Journal of diabetes research 2023;2023:7423661
Journal of diabetes research 2023;2023:7423661
Transcutaneous Electrical Nerve Stimulation (TENS) Alleviates Brain Ischemic Injury by Regulating Neuronal Oxidative Stress, Pyroptosis, and Mitophagy.
Tan Z, Dong F, Wu L, Feng Y, Zhang M, Zhang F
Mediators of inflammation 2023;2023:5677865
Mediators of inflammation 2023;2023:5677865
Hemoglobin Derived from Subarachnoid Hemorrhage-Induced Pyroptosis of Neural Stem Cells via ROS/NLRP3/GSDMD Pathway.
Yue T, Li X, Chen X, Zhu T, Li W, Wang B, Hang C
Oxidative medicine and cellular longevity 2023;2023:4383332
Oxidative medicine and cellular longevity 2023;2023:4383332
HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis in a Sepsis Model.
He YF, Hu XM, Khan MA, Yu BY, Sheng YC, Xiao XZ, Wan XX, Tan SP, Xiong K
Mediators of inflammation 2023;2023:2252255
Mediators of inflammation 2023;2023:2252255
Curcumin Ameliorates Age-Induced Tight Junction Impaired in Porcine Sertoli Cells by Inactivating the NLRP3 Inflammasome through the AMPK/SIRT3/SOD2/mtROS Signaling Pathway.
Xiao L, Fang Z, Wang Q, Sheng X, Qi X, Xing K, Guo Y, Ni H, Wang X, Zhang Y
Oxidative medicine and cellular longevity 2023;2023:1708251
Oxidative medicine and cellular longevity 2023;2023:1708251
RBCK1 Overexpression Attenuates Inflammation and Mobility of Derp1-Induced Nasal Mucosal Cells by Downregulating NLRP3.
Du J, Peng L, Feng J, Zhang T
International archives of allergy and immunology 2023;184(5):471-480
International archives of allergy and immunology 2023;184(5):471-480
Transcutaneous electrical acupoint stimulation alleviates cerebral ischemic injury through the TLR4/MyD88/NF-κ B pathway.
Wu L, Tan Z, Su L, Dong F, Xu G, Zhang F
Frontiers in cellular neuroscience 2023;17:1343842
Frontiers in cellular neuroscience 2023;17:1343842
Aspirin-triggered Resolvin D1 ameliorates activation of the NLRP3 inflammasome via induction of autophagy in a rat model of neuropathic pain.
Wang YH, Tang YR, Gao X, Zhang NN, Lv QQ, Liu J, Li Y
Frontiers in pharmacology 2023;14:971136
Frontiers in pharmacology 2023;14:971136
The influence of angiopoietin-like protein 3 on macrophages polarization and its effect on the podocyte EMT in diabetic nephropathy.
Ma Y, Chen Y, Xu H, Du N
Frontiers in immunology 2023;14:1228399
Frontiers in immunology 2023;14:1228399
Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation.
Xu L, Zeng Z, Niu C, Liu D, Lin S, Liu X, Szabó G, Lu J, Zheng S, Zhou P
Frontiers in cardiovascular medicine 2023;10:1126391
Frontiers in cardiovascular medicine 2023;10:1126391
Epigallocatechin gallate alleviates mono-2-ethylhexyl phthalate-induced male germ cell pyroptosis by inhibiting the ROS/mTOR/NLRP3 pathway.
Hong Y, Zhou X, Li Q, Chen J, Wei Y, Shen L, Long C, Wu S, Wei G
Toxicology in vitro : an international journal published in association with BIBRA 2023 Sep;91:105626
Toxicology in vitro : an international journal published in association with BIBRA 2023 Sep;91:105626
Pseudorabies virus infection activates the NLRP3 and IFI16 inflammasomes to trigger pyroptosis.
Zhang X, Chen G, Yin J, Li L, Huang K, Du Q, Tong D, Huang Y
Veterinary microbiology 2023 Sep;284:109826
Veterinary microbiology 2023 Sep;284:109826
Maslinic acid alleviates LPS-induced mice mastitis by inhibiting inflammatory response, maintaining the integrity of the blood-milk barrier and regulating intestinal flora.
Li K, Ran X, Zeng Y, Li S, Hu G, Wang X, Li Y, Yang Z, Liu J, Fu S
International immunopharmacology 2023 Sep;122:110551
International immunopharmacology 2023 Sep;122:110551
NDUFC2 deficiency exacerbates endothelial mesenchymal transformation during ischemia-reperfusion via NLRP3.
Chen J, Liu X, Bi R, Liu P, Gong W
Neuroreport 2023 Sep 6;34(13):670-676
Neuroreport 2023 Sep 6;34(13):670-676
MicroRNA miR-223 modulates NLRP3 and Keap1, mitigating lipopolysaccharide-induced inflammation and oxidative stress in bovine mammary epithelial cells and murine mammary glands.
Zhou M, Barkema HW, Gao J, Yang J, Wang Y, Kastelic JP, Khan S, Liu G, Han B
Veterinary research 2023 Sep 14;54(1):78
Veterinary research 2023 Sep 14;54(1):78
Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme.
Chan AH, Burgener SS, Vezyrgiannis K, Wang X, Acklam J, Von Pein JB, Pizzuto M, Labzin LI, Boucher D, Schroder K
Life science alliance 2023 Oct;6(10)
Life science alliance 2023 Oct;6(10)
Ghrelin inhibits NLRP3 inflammasome activation by upregulating autophagy to improve Alzheimer's disease.
Guo Y, Zhang L
In vitro cellular & developmental biology. Animal 2023 Oct;59(9):665-673
In vitro cellular & developmental biology. Animal 2023 Oct;59(9):665-673
Ampelopsin attenuates Staphylococcus aureus Alpha-Toxin-Induced Lung Injury.
Wang Y, Tang M, Deng H, Hong Z, Liang Z, Huang Y, Zeng C, Yang K
Microbial pathogenesis 2023 Oct;183:106316
Microbial pathogenesis 2023 Oct;183:106316
HMGB1 induces macrophage pyroptosis in chronic endometritis.
Yang G, Zhang Q, Tan J, Xiong Y, Liang Y, Yan J, Gu F, Xu Y
International immunopharmacology 2023 Oct;123:110706
International immunopharmacology 2023 Oct;123:110706
Systemic pharmacology reveal the mechanism by which the Qiangjin Zhuanggu Qufeng mixture inhibits LPS-induced pyroptosis of rat nucleus pulposus cells.
Wang D, Zhang L, He D, Zhang Y, Bao J, Gao W, Cheng W, Zhu C, Jin H, Zhang W, Zhu H, Pan H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:154998
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:154998
Down-regulation of OIP5-AS1 inhibits obesity-induced myocardial pyroptosis and miR-22/NLRP3 inflammasome axis.
Yue Q, Liu Y, Ji J, Hu T, Lin T, Yu S, Li S, Wu N
Immunity, inflammation and disease 2023 Oct;11(10):e1066
Immunity, inflammation and disease 2023 Oct;11(10):e1066
Deficient chaperone-mediated autophagy facilitates LPS-induced microglial activation via regulation of the p300/NF-κB/NLRP3 pathway.
Wu J, Han Y, Xu H, Sun H, Wang R, Ren H, Wang G
Science advances 2023 Oct 6;9(40):eadi8343
Science advances 2023 Oct 6;9(40):eadi8343
ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer.
Su P, Mao X, Ma J, Huang L, Yu L, Tang S, Zhuang M, Lu Z, Osafo KS, Ren Y, Wang X, Lin X, Huang L, Huang X, Braicu EI, Sehouli J, Sun P
Journal of experimental & clinical cancer research : CR 2023 Oct 20;42(1):274
Journal of experimental & clinical cancer research : CR 2023 Oct 20;42(1):274
Posttranslational ISGylation of NLRP3 by HERC enzymes facilitates inflammasome activation in models of inflammation.
Qin Y, Meng X, Wang M, Liang W, Xu R, Chen J, Song H, Fu Y, Li J, Gao C, Jia M, Zhao C, Zhao W
The Journal of clinical investigation 2023 Oct 16;133(20)
The Journal of clinical investigation 2023 Oct 16;133(20)
Role of NLRP3 in the exacerbation of ozone-induced allergic rhinitis.
Zhang X, Sun N, Huang Y, Duan Y, Zhang R
Ecotoxicology and environmental safety 2023 Oct 15;265:115506
Ecotoxicology and environmental safety 2023 Oct 15;265:115506
Downregulation of XBP1s aggravates lipopolysaccharide-induced inflammation by promoting NF-κB and NLRP3 pathways' activation in goat endometrial epithelial cells.
Gao K, Yi Y, Xue Z, Wang Z, Huang S, Zhang B, Lin P, Wang A, Chen H, Jin Y
Theriogenology 2023 Oct 15;210:119-132
Theriogenology 2023 Oct 15;210:119-132
Aluminum exposure induces central nervous system impairment via activating NLRP3-medicated pyroptosis pathway.
Hao W, Zhu X, Liu Z, Song Y, Wu S, Lu X, Yang J, Jin C
Ecotoxicology and environmental safety 2023 Oct 1;264:115401
Ecotoxicology and environmental safety 2023 Oct 1;264:115401
Role and anti-inflammatory mechanisms of acupuncture and moxibustion therapy on pain relief through NOX-ROS-NLRP3 pathway in CCI rats models.
Jinying W, Keming L, Hanqing T, Xuqing Z, Muccee F, Xuan L, Yalin L, Meiye S, Shumin Z, Selvaraj C, Safi SZ
Molecular biology reports 2023 Nov;50(11):9367-9378
Molecular biology reports 2023 Nov;50(11):9367-9378
AR/PCC herb pair inhibits osteoblast pyroptosis to alleviate diabetes-related osteoporosis by activating Nrf2/Keap1 pathway.
Fu F, Luo H, Du Y, Chen Y, Tian K, Pan J, Li J, Wang N, Bao R, Jin H, Tong P, Ruan H, Wu C
Journal of cellular and molecular medicine 2023 Nov;27(22):3601-3613
Journal of cellular and molecular medicine 2023 Nov;27(22):3601-3613
An HPK1 inhibitor enhanced the tumour response to anti-PD-1 immunotherapy in non-Hodgkin's lymphoma.
Yang L, Zhao Q, Chen T, Liu W, Qiu X, Chen J, Huang S, Huang R, Dong L
Clinical and experimental medicine 2023 Nov;23(7):3767-3780
Clinical and experimental medicine 2023 Nov;23(7):3767-3780
Selenium Deficiency via the ROS/NLRP3/IL-1β Signaling Pathway Leads to Pyroptosis Injury in Pig Spleen.
Song L, Jiang Z, Zhang X, Song Y, Xing Y, Wang G
Biological trace element research 2023 Nov;201(11):5192-5200
Biological trace element research 2023 Nov;201(11):5192-5200
Escherichia coli infection mediates pyroptosis via activating p53-p21 pathway-regulated apoptosis and cell cycle arrest in bovine mammary epithelial cells.
Zhuang C, Zhao J, Zhang S, Shahid M
Microbial pathogenesis 2023 Nov;184:106338
Microbial pathogenesis 2023 Nov;184:106338
Carnosine alleviates cisplatin-induced acute kidney injury by targeting Caspase-1 regulated pyroptosis.
Luo X, Li Y, Wang B, Zhu S, Liu X, Liu X, Qi X, Wu Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115563
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115563
Lipopolysaccharide promotes NLRP3 inflammasome activation by inhibiting TFEB-mediated autophagy in NRK-52E cells.
Song D, Tao W, Liu F, Wu X, Bi H, Shu J, Wang D, Li X
Molecular immunology 2023 Nov;163:127-135
Molecular immunology 2023 Nov;163:127-135
Inhibition of Caspase-1-mediated pyroptosis promotes osteogenic differentiation, offering a therapeutic target for osteoporosis.
Ruan H, Zhang H, Feng J, Luo H, Fu F, Yao S, Zhou C, Zhang Z, Bian Y, Jin H, Zhang Y, Wu C, Tong P
International immunopharmacology 2023 Nov;124(Pt B):110901
International immunopharmacology 2023 Nov;124(Pt B):110901
Trans-anethole pretreatment ameliorates hepatic ischemia-reperfusion injury via regulation of soluble epoxide hydrolase.
Lu J, Hou W, Yang S, Chen D, Wang F, Liu L, Shen Z
International immunopharmacology 2023 Nov;124(Pt A):110809
International immunopharmacology 2023 Nov;124(Pt A):110809
Melatonin alleviates intrarenal CaOx crystals deposition through inhibiting LPS-induced non-canonical inflammasome-mediated renal tubular epithelial cells pyroptosis.
Yao K, Zhang ZH, Liu MD, Niu FW, Li X, Ding DM, Wang DM, Yu DX, Xu DX, Xie DD
International immunopharmacology 2023 Nov;124(Pt A):110796
International immunopharmacology 2023 Nov;124(Pt A):110796
Pyroptosis of chondrocytes activated by synovial inflammation accelerates TMJ osteoarthritis cartilage degeneration via ROS/NLRP3 signaling.
Liu X, Li Y, Zhao J, Hu Z, Fang W, Ke J, Li W, Long X
International immunopharmacology 2023 Nov;124(Pt A):110781
International immunopharmacology 2023 Nov;124(Pt A):110781
Mesenchymal stem cell-derived exosomal miR-548x-3p inhibits pyroptosis of vascular endothelial cells through HMGB1 in heat stroke.
Pei Y, Ma W, Wang H, Chen F, Xiao W, Fan M, Han X, Cao Y
Genomics 2023 Nov;115(6):110719
Genomics 2023 Nov;115(6):110719
Resatorvid alleviates experimental inflammatory TMJOA by restraining chondrocyte pyroptosis and synovial inflammation.
Liu X, Li H, Feng Y, Guo H, Li Y, Ke J, Long X
Arthritis research & therapy 2023 Nov 29;25(1):230
Arthritis research & therapy 2023 Nov 29;25(1):230
Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer.
Xie W, Peng M, Liu Y, Zhang B, Yi L, Long Y
Cell communication and signaling : CCS 2023 Nov 16;21(1):329
Cell communication and signaling : CCS 2023 Nov 16;21(1):329
Injectable kaempferol-loaded fibrin glue regulates the metabolic balance and inhibits inflammation in intervertebral disc degeneration.
Gao W, Bao J, Zhang Y, He D, Zhang L, Zhang J, Pan H, Wang D
Scientific reports 2023 Nov 15;13(1):20001
Scientific reports 2023 Nov 15;13(1):20001
STING contributes to trauma-induced heterotopic ossification through NLRP3-dependent macrophage pyroptosis.
Sun Z, Liu H, Hu Y, Luo G, Yuan Z, Tu B, Ruan H, Li J, Fan C
Clinical immunology (Orlando, Fla.) 2023 May;250:109300
Clinical immunology (Orlando, Fla.) 2023 May;250:109300
The involvement of DDX3X in compression-induced nucleus pulposus pyroptosis.
Chi S, Li S, Xu Z, Yang G, Song Y, Liao Z, Yang C, Wu X
Biochemical and biophysical research communications 2023 May 7;655:1-10
Biochemical and biophysical research communications 2023 May 7;655:1-10
MALAT1 participates in the role of platelet-rich plasma exosomes in promoting wound healing of diabetic foot ulcer.
Chen C, Wang Q, Li D, Qi Z, Chen Y, Wang S
International journal of biological macromolecules 2023 May 31;238:124170
International journal of biological macromolecules 2023 May 31;238:124170
HuNoV Non-Structural Protein P22 Induces Maturation of IL-1β and IL-18 and N-GSDMD-Dependent Pyroptosis through Activating NLRP3 Inflammasome.
Chen N, Chen P, Zhou Y, Chen S, Gong S, Fu M, Geng L
Vaccines 2023 May 17;11(5)
Vaccines 2023 May 17;11(5)
β-Hydroxybutyric acid upregulated by Suhuang antitussive capsule ameliorates cough variant asthma through GSK3β/AMPK-Nrf2 signal axis.
Jiang H, Bai Z, Ou Y, Liu H, Si Z, Liu Y, Liu X, Liu X, Zhang Z, Tan N
Journal of ethnopharmacology 2023 May 10;307:116013
Journal of ethnopharmacology 2023 May 10;307:116013
Heat-killed Lactobacillus murinus confers neuroprotection against dopamine neuronal loss by targeting NLRP3 inflammasome.
Fan HX, Sheng S, Li DD, Li JJ, Wang GQ, Zhang F
Bioengineering & translational medicine 2023 Mar;8(2):e10455
Bioengineering & translational medicine 2023 Mar;8(2):e10455
hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration.
Chen D, Jiang X, Zou H
Journal of orthopaedic translation 2023 Mar;39:163-176
Journal of orthopaedic translation 2023 Mar;39:163-176
Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis.
Chen Y, Liu Y, Jiang K, Wen Z, Cao X, Wu S
Journal of orthopaedic translation 2023 Mar;39:1-11
Journal of orthopaedic translation 2023 Mar;39:1-11
Long-term exercise preserves pancreatic islet structure and β-cell mass through attenuation of islet inflammation and fibrosis.
Carvalho VHC, Wang Q, Xu X, Liu L, Jiang W, Wang X, Wang J, Li W, Chen J, Li T, Chen Y, Zhu W, Sun Z, Qiu S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Mar;37(3):e22822
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Mar;37(3):e22822
Protective effects of baicalin against L-glutamate-induced oxidative damage in HT-22 cells by inhibiting NLRP3 inflammasome activation via Nrf2/HO-1 signaling.
Li J, Wang G, Zhang Y, Fan X, Yao M
Iranian journal of basic medical sciences 2023 Mar;26(3):351-358
Iranian journal of basic medical sciences 2023 Mar;26(3):351-358
Cytotoxic steroidal glycosides from the rhizomes of Paris polyphylla var. yunnanensis.
Liu Y, Liu MY, Bi LL, Tian YY, Qiu PC, Qian XY, Wang MC, Tang HF, Lu YY, Zhang BL
Phytochemistry 2023 Mar;207:113577
Phytochemistry 2023 Mar;207:113577
TMEM16F may be a new therapeutic target for Alzheimer's disease.
Cui ZQ, Hu XY, Yang T, Guan JW, Gu Y, Li HY, Zhang HY, Xiao QH, Sun XH
Neural regeneration research 2023 Mar;18(3):643-651
Neural regeneration research 2023 Mar;18(3):643-651
Protective effecs of baicalin magnesium on non-alcoholic steatohepatitis rats are based on inhibiting NLRP3/Caspase-1/IL-1β signaling pathway.
Guan X, Shen S, Liu J, Song H, Chang J, Mao X, Song J, Zhang L, Liu C
BMC complementary medicine and therapies 2023 Mar 6;23(1):72
BMC complementary medicine and therapies 2023 Mar 6;23(1):72
Emodin alleviates testicular ischemia-reperfusion injury through the inhibition of NLRP3-mediated pyroptosis.
He KX, Ning JZ, Li W, Cheng F
Tissue & cell 2023 Jun;82:102069
Tissue & cell 2023 Jun;82:102069
Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma.
Zeng Z, You M, Fan C, Rong R, Li H, Xia X
Redox biology 2023 Jun;62:102687
Redox biology 2023 Jun;62:102687
Salmonella typhimurium exacerbates injuries but resolves fibrosis in liver and spleen during Schistosoma mansoni infection.
Lam HYP, Wu WJ, Liang TR, Li HC, Chang KC, Peng SY
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2023 Jun;56(3):477-489
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2023 Jun;56(3):477-489
LOXL1-AS1 Aggravates Myocardial Ischemia/Reperfusion Injury Through the miR-761/PTEN Axis.
He W, Duan L, Zhang L
Korean circulation journal 2023 Jun;53(6):387-403
Korean circulation journal 2023 Jun;53(6):387-403
Trehalose prevents glyphosate-induced hepatic steatosis in roosters by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation.
Lian CY, Wang RZ, Wang J, Wang ZY, Zhang W, Wang L
Veterinary research communications 2023 Jun;47(2):651-661
Veterinary research communications 2023 Jun;47(2):651-661
Serum amyloid A and interleukin -1β facilitate LDL transcytosis across endothelial cells and atherosclerosis via NF-κB/caveolin-1/cavin-1 pathway.
Jia X, Liu Z, Wang Y, Li G, Bai X
Atherosclerosis 2023 Jun;375:87-97
Atherosclerosis 2023 Jun;375:87-97
Du Huo Ji Sheng Tang inhibits Notch1 signaling and subsequent NLRP3 activation to alleviate cartilage degradation in KOA mice.
Chen WJ, Zhuang Y, Peng W, Cui W, Zhang SJ, Wang JW
Chinese medicine 2023 Jun 29;18(1):80
Chinese medicine 2023 Jun 29;18(1):80
Fucoxanthin alleviated atherosclerosis by regulating PI3K/AKT and TLR4/NFκB mediated pyroptosis in endothelial cells.
Cui S, Wu H, He Q, Wang L, Yi X, Feng G, Wu Q, Tao B, Han D, Hu Q, Xia H, Xu L
International immunopharmacology 2023 Jul;120:110370
International immunopharmacology 2023 Jul;120:110370
Evidence on the therapeutic role of thiolutin in imiquimod-induced psoriasis-like skin inflammation in mice.
Wang A, Ma X, Wei F, Li Y, Liu Q, Zhang H
Immunity, inflammation and disease 2023 Jul;11(7):e877
Immunity, inflammation and disease 2023 Jul;11(7):e877
Acid-sensing ion channel 1a exacerbates renal ischemia-reperfusion injury through the NF-κB/NLRP3 inflammasome pathway.
Yang Y, Jin S, Zhang J, Chen W, Lu Y, Chen J, Yan Z, Shen B, Ning Y, Shi Y, Chen J, Wang J, Xu S, Jia P, Teng J, Fang Y, Song N, Ding X
Journal of molecular medicine (Berlin, Germany) 2023 Jul;101(7):877-890
Journal of molecular medicine (Berlin, Germany) 2023 Jul;101(7):877-890
An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation.
Yiu SPT, Zerbe C, Vanderwall D, Huttlin EL, Weekes MP, Gewurz BE
Molecular cell 2023 Jul 6;83(13):2367-2386.e15
Molecular cell 2023 Jul 6;83(13):2367-2386.e15
Fibrin glue delivery system containing rhein ameliorates intervertebral disc degeneration by anti-inflammatory efficacy.
Bao J, Gao W, Zhang W, Wang D, Pan H
Journal of orthopaedic surgery and research 2023 Jul 6;18(1):485
Journal of orthopaedic surgery and research 2023 Jul 6;18(1):485
The protective effects of sophocarpine on sepsis-induced cardiomyopathy.
Fu Y, Zhang HJ, Zhou W, Lai ZQ, Dong YF
European journal of pharmacology 2023 Jul 5;950:175745
European journal of pharmacology 2023 Jul 5;950:175745
circACTA2 inhibits NLRP3 inflammasome-mediated inflammation via interacting with NF-κB in vascular smooth muscle cells.
Bai Y, Zhang L, Zheng B, Zhang X, Zhang H, Zhao A, Yu J, Yang Z, Wen J
Cellular and molecular life sciences : CMLS 2023 Jul 27;80(8):229
Cellular and molecular life sciences : CMLS 2023 Jul 27;80(8):229
Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia.
Chen Q, He J, Liu H, Huang Q, Wang S, Yin A, Chen S, Shen X, Xiao Y, Hu H, Jiang J, Chen W, Wang S, Huang Z, Li J, Peng Y, Wang X, Yang X, Wang Z, Zhong M
Journal of translational medicine 2023 Jul 24;21(1):496
Journal of translational medicine 2023 Jul 24;21(1):496
Forsythiaside A Alleviates Lipopolysaccharide-Induced Acute Liver Injury through Inhibiting Endoplasmic Reticulum Stress and NLRP3 Inflammasome Activation.
Fu JN, Liu SC, Chen Y, Zhao J, Lu N, Ma T
Biological & pharmaceutical bulletin 2023 Jul 1;46(7):979-986
Biological & pharmaceutical bulletin 2023 Jul 1;46(7):979-986
Down-regulated Smyd1 participated in the inhibition of myoblast differentiation induced by cigarette smoke extract.
Li F, Xu M, Miao J, Hu N, Wang Y, Wang L
Toxicology letters 2023 Jul 1;383:98-111
Toxicology letters 2023 Jul 1;383:98-111
Multi-omics analysis reveals BDE47 induces depression-like behaviors in mice by interfering with the 2-arachidonoyl glycerol-associated microbiota-gut-brain axis.
Wang CQ, Su Z, Dai CG, Song JL, Qian B
Ecotoxicology and environmental safety 2023 Jul 1;259:115041
Ecotoxicology and environmental safety 2023 Jul 1;259:115041
Identification of PIK3CG as a hub in septic myocardial injury using network pharmacology and weighted gene co-expression network analysis.
Liu Q, Dong Y, Escames G, Wu X, Ren J, Yang W, Zhang S, Zhu Y, Tian Y, Acuña-Castroviejo D, Yang Y
Bioengineering & translational medicine 2023 Jan;8(1):e10384
Bioengineering & translational medicine 2023 Jan;8(1):e10384
The Correlation between Increased Expressions of NLRP3 Inflammasome Components in Peripheral Blood Mono-Nuclear Cells and Plaque Vulnerability in Human Carotid Atherosclerosis.
Xie W, Shi X, Lee H, Wang L, Niu N, Qu P
Iranian journal of public health 2023 Jan;52(1):147-158
Iranian journal of public health 2023 Jan;52(1):147-158
Salidroside protects pancreatic β-cells against pyroptosis by regulating the NLRP3/GSDMD pathway in diabetic conditions.
Zhou J, Yan S, Guo X, Gao Y, Chen S, Li X, Zhang Y, Wang Q, Zheng T, Chen L
International immunopharmacology 2023 Jan;114:109543
International immunopharmacology 2023 Jan;114:109543
Involvement of Galectin-3 in neurocognitive impairment in obstructive sleep apnea via regulating inflammation and oxidative stress through NLRP3.
Zong D, Liu X, Shen C, Liu T, Ouyang R
Sleep medicine 2023 Jan;101:1-10
Sleep medicine 2023 Jan;101:1-10
Epigenetic control of LncRNA NEAT1 enables cardiac fibroblast pyroptosis and cardiac fibrosis.
Ding JF, Zhou Y, Xu SS, Shi KH, Sun H, Tu B, Song K, Xuan HY, Sha JM, Zhao JY, Tao H
European journal of pharmacology 2023 Jan 5;938:175398
European journal of pharmacology 2023 Jan 5;938:175398
NAMPT encapsulated by extracellular vesicles from young adipose-derived mesenchymal stem cells treated tendinopathy in a "One-Stone-Two-Birds" manner.
Wu G, Su Q, Li J, Xue C, Zhu J, Cai Q, Huang J, Ji S, Cheng B, Ge H
Journal of nanobiotechnology 2023 Jan 5;21(1):7
Journal of nanobiotechnology 2023 Jan 5;21(1):7
Proteogenomics of diffuse gliomas reveal molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms.
Wang Y, Luo R, Zhang X, Xiang H, Yang B, Feng J, Deng M, Ran P, Sujie A, Zhang F, Zhu J, Tan S, Xie T, Chen P, Yu Z, Li Y, Jiang D, Zhang X, Zhao JY, Hou Y, Ding C
Nature communications 2023 Jan 31;14(1):505
Nature communications 2023 Jan 31;14(1):505
Pmorf0222, a Virulence Factor in Pasteurella multocida, Activates Nuclear Factor Kappa B and Mitogen-Activated Protein Kinase via Toll-Like Receptor 1/2.
Xu T, Zheng Y, Liu B, Kou M, Jiang Q, Liu J, Kang H, Yang M, Guo D, Qu L
Infection and immunity 2023 Jan 24;91(1):e0019322
Infection and immunity 2023 Jan 24;91(1):e0019322
Jatrorrhizine Suppresses Murine-Norovirus-Triggered N-GSDMD-Dependent Pyroptosis in RAW264.7 Macrophages.
Fu M, Chen N, Zhou Y, Chen S, Xu W, Gong S, Geng L
Vaccines 2023 Jan 12;11(1)
Vaccines 2023 Jan 12;11(1)
The combined effect of deoxynivalenol and Fumonisin B(1) on small intestinal inflammation mediated by pyroptosis in vivo and in vitro.
Mao X, Zhang P, Du H, Ge L, Liu S, Huang K, Chen X
Toxicology letters 2023 Jan 1;372:25-35
Toxicology letters 2023 Jan 1;372:25-35
Cadmium exposure promotes thyroid pyroptosis and endocrine dysfunction by inhibiting Nrf2/Keap1 signaling.
Chen Y, Zhou C, Bian Y, Fu F, Zhu B, Zhao X, Zhang M, Zhou C, Yao S, Zhang Z, Luo H, Ge Y, Wu C, Ruan H
Ecotoxicology and environmental safety 2023 Jan 1;249:114376
Ecotoxicology and environmental safety 2023 Jan 1;249:114376
Aluminum induces neuroinflammation via P2X7 receptor activating NLRP3 inflammasome pathway.
Zhu X, Hao W, Liu Z, Song Y, Hao C, Wu S, Lu X, Yang J, Jin C
Ecotoxicology and environmental safety 2023 Jan 1;249:114373
Ecotoxicology and environmental safety 2023 Jan 1;249:114373
VX-765 attenuates silica-induced lung inflammatory injury and fibrosis by modulating alveolar macrophages pyroptosis in mice.
Tao H, Zhao H, Mo A, Shao L, Ge D, Liu J, Hu W, Xu K, Ma Q, Wang W, Wang W, Cao H, Mu M, Tao X, Wang J
Ecotoxicology and environmental safety 2023 Jan 1;249:114359
Ecotoxicology and environmental safety 2023 Jan 1;249:114359
Taurine alleviates ochratoxin A-induced pyroptosis in PK-15 cells by inhibiting oxidative stress.
Qu J, Liu K, Liu S, Yue D, Zhang P, Mao X, He W, Huang K, Chen X
Journal of biochemical and molecular toxicology 2023 Feb;37(2):e23249
Journal of biochemical and molecular toxicology 2023 Feb;37(2):e23249
Exercise induced meteorin-like protects chondrocytes against inflammation and pyroptosis in osteoarthritis by inhibiting PI3K/Akt/NF-κB and NLRP3/caspase-1/GSDMD signaling.
Liu J, Jia S, Yang Y, Piao L, Wang Z, Jin Z, Bai L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Feb;158:114118
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Feb;158:114118
Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis.
Jiang X, Lu Z, Zhang Q, Yu J, Han D, Liu J, Li P, Li F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154640
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154640
Ginsenoside Rg3 Ameliorates DSS-Induced Colitis by Inhibiting NLRP3 Inflammasome Activation and Regulating Microbial Homeostasis.
Liu D, Tian Q, Liu K, Ren F, Liu G, Zhou J, Yuan L, Fang Z, Zou B, Wang S
Journal of agricultural and food chemistry 2023 Feb 8;
Journal of agricultural and food chemistry 2023 Feb 8;
Notopterol Ameliorates Hyperuricemia-Induced Cardiac Dysfunction in Mice.
Wang Q, Peng D, Huang B, Men L, Jiang T, Huo S, Wang M, Guo J, Lv J, Lin L
Pharmaceuticals (Basel, Switzerland) 2023 Feb 27;16(3)
Pharmaceuticals (Basel, Switzerland) 2023 Feb 27;16(3)
Hydrogen Sulfide Inhibited Sympathetic Activation in D-Galactose-Induced Aging Rats by Upregulating Klotho and Inhibiting Inflammation in the Paraventricular Nucleus.
Yu H, Yu Q, Mi Y, Wang P, Jin S, Xiao L, Guo Q, Wu Y
Biomedicines 2023 Feb 15;11(2)
Biomedicines 2023 Feb 15;11(2)
HBx-induced PLA(2)R overexpression mediates podocyte pyroptosis through the ROS-NLRP3 signaling pathway.
Feng M, Yu Y, Chen Y, Yang X, Li B, Jiang W
Renal failure 2023 Dec;45(1):2170808
Renal failure 2023 Dec;45(1):2170808
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Wang HG, Wang D, Sarfraz M, Afzal A, Jing MR, Zhang YX, Cai CB, Qi HW, Chen HJ, Li T, Hu SJ, Liu HX, Ji XY, Wu DD
Translational oncology 2023 Dec;38:101770
Translational oncology 2023 Dec;38:101770
Tryptophan alleviates lipopolysaccharide-induced liver injury and inflammation by modulating necroptosis and pyroptosis signaling pathways in piglets.
Gu K, Wang F, Sun W, Liu G, Jia G, Zhao H, Chen X, Wu C, Tian G, Cai J, Zhang R, Wang J
Animal biotechnology 2023 Dec;34(8):4069-4080
Animal biotechnology 2023 Dec;34(8):4069-4080
Hypoxia-inducible factor 1α activates the NLRP3 inflammasome to regulate epithelial differentiation in chronic rhinosinusitis.
Zhong B, Sun S, Tan KS, Ong HH, Du J, Liu F, Liu Y, Liu S, Ba L, Li J, Wang Y, Liu J
The Journal of allergy and clinical immunology 2023 Dec;152(6):1444-1459.e14
The Journal of allergy and clinical immunology 2023 Dec;152(6):1444-1459.e14
Berberine ameliorates renal interstitial inflammation and fibrosis in mice with unilateral ureteral obstruction.
Tan E, Gao Z, Wang Q, Han B, Shi H, Wang L, Zhu G, Hou Y
Basic & clinical pharmacology & toxicology 2023 Dec;133(6):757-769
Basic & clinical pharmacology & toxicology 2023 Dec;133(6):757-769
Puerarin-Tanshinone IIA Suppresses atherosclerosis inflammatory plaque via targeting succinate/HIF-1α/IL-1β axis.
Xu J, Tian Z, Li Z, Du X, Cui Y, Wang J, Gao M, Hou Y
Journal of ethnopharmacology 2023 Dec 5;317:116675
Journal of ethnopharmacology 2023 Dec 5;317:116675
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression.
Cong L, Liu X, Bai Y, Qin Q, Zhao L, Shi Y, Bai Y, Guo Z
Biological research 2023 Dec 2;56(1):62
Biological research 2023 Dec 2;56(1):62
Paeoniflorin recued hepatotoxicity under zinc oxide nanoparticles exposure via regulation on gut-liver axis and reversal of pyroptosis.
Pei X, Tang S, Jiang H, Zhang W, Xu G, Zuo Z, Ren Z, Chen C, Shen Y, Li C, Li D
The Science of the total environment 2023 Dec 15;904:166885
The Science of the total environment 2023 Dec 15;904:166885
Ginsenoside Rg1 Alleviates Lipopolysaccharide-Induced Fibrosis of Endometrial Epithelial Cells in Dairy Cows by Inhibiting Reactive Oxygen Species-Activated NLRP3.
Song L, Wang L, Li X, Xiao L
Animals : an open access journal from MDPI 2023 Dec 1;13(23)
Animals : an open access journal from MDPI 2023 Dec 1;13(23)
Ginsenoside compound K alleviates osteoarthritis by inhibiting NLRP3‑mediated pyroptosis.
Li Y, Wu J, Zhuo N
Experimental and therapeutic medicine 2023 Aug;26(2):406
Experimental and therapeutic medicine 2023 Aug;26(2):406
Hyperuricemia promotes the progression of atherosclerosis by activating endothelial cell pyroptosis via the ROS/NLRP3 pathway.
He B, Nie Q, Wang F, Wang X, Zhou Y, Wang C, Guo J, Fan X, Ye Z, Liu P, Wen J
Journal of cellular physiology 2023 Aug;238(8):1808-1822
Journal of cellular physiology 2023 Aug;238(8):1808-1822
Effects of sodium metabisulfite on pyroptosis, mitophagy and degranulation in mast cells.
Liu M, Lu J, Liu Q, Chen Y, Wang G, Zhang Q, Guan S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Aug;178:113918
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Aug;178:113918
MiR-195-5p is involved in testicular ischemia/reperfusion injury by directly targeting PELP1 and regulating spermatogonia pyroptosis.
He KX, Xu L, Ning JZ, Cheng F
International immunopharmacology 2023 Aug;121:110427
International immunopharmacology 2023 Aug;121:110427
Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis.
Gao Z, Zhan H, Zong W, Sun M, Linghu L, Wang G, Meng F, Chen M
Life sciences 2023 Aug 15;327:121793
Life sciences 2023 Aug 15;327:121793
NLRP3 mediates the neuroprotective effects of SVHRSP derived from scorpion venom in rotenone-induced experimental Parkinson's disease model.
Zhang Y, Li S, Hou L, Wu M, Liu J, Wang R, Wang Q, Zhao J
Journal of ethnopharmacology 2023 Aug 10;312:116497
Journal of ethnopharmacology 2023 Aug 10;312:116497
SARS-CoV-2 E protein-induced THP-1 pyroptosis is reversed by Ruscogenin.
Huang H, Li X, Zha D, Lin H, Yang L, Wang Y, Xu L, Wang L, Lei T, Zhou Z, Xiao YF, Xin HB, Fu M, Qian Y
Biochemistry and cell biology = Biochimie et biologie cellulaire 2023 Aug 1;101(4):303-312
Biochemistry and cell biology = Biochimie et biologie cellulaire 2023 Aug 1;101(4):303-312
PTTG1 alleviates acute alcoholic liver injury by inhibiting endoplasmic reticulum stress-induced hepatocyte pyroptosis.
Tien S, Zhou H, Zhou Q, Liu H, Wu B, Guo Y
Liver international : official journal of the International Association for the Study of the Liver 2023 Apr;43(4):840-854
Liver international : official journal of the International Association for the Study of the Liver 2023 Apr;43(4):840-854
Bufalin alleviates acute kidney injury by regulating NLRP3 inflammasome-mediated pyroptosis.
Ding L, Yin J, Xu X, Xie D, Xiang D, Tong P, Liu S, Yang X
Apoptosis : an international journal on programmed cell death 2023 Apr;28(3-4):539-548
Apoptosis : an international journal on programmed cell death 2023 Apr;28(3-4):539-548
PRRSV infection activates NLRP3 inflammasome through inducing cytosolic mitochondrial DNA stress.
Li H, Yang X, Song Y, Zhu Q, Liao Z, Liang Y, Guo J, Wan B, Bao D
Veterinary microbiology 2023 Apr;279:109673
Veterinary microbiology 2023 Apr;279:109673
Bullatine A has an antidepressant effect in chronic social defeat stress mice; Implication of microglial inflammasome.
Zhang JR, Yin SY, Shen ZQ, Li B, Zhang YQ, Yu J
Brain research bulletin 2023 Apr;195:130-140
Brain research bulletin 2023 Apr;195:130-140
Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3β/Nrf2 signaling-mediated ferroptosis in vivo and in vitro.
Dong C, Song C, He Z, Song Q, Song T, Liu J, Xiong Y, Su X, Zhou J, Yang S, Liao W
International immunopharmacology 2023 Apr;117:110042
International immunopharmacology 2023 Apr;117:110042
Ginsenoside Rb1 alleviated concanavalin A-induced hepatocyte pyroptosis by activating mitophagy.
Zhang Q, Hu J, Mao A, Liu M, Guan S, Lu J
Food & function 2023 Apr 24;14(8):3793-3803
Food & function 2023 Apr 24;14(8):3793-3803
Pyroptosis-Mediated Damage Mechanism by Deoxynivalenol in Porcine Small Intestinal Epithelial Cells.
Kang TH, Shin S, Park J, Lee BR, Lee SI
Toxins 2023 Apr 19;15(4)
Toxins 2023 Apr 19;15(4)
Prevention of the Pro-Aggressive Effects of Ethanol-Intoxicated Mice by Schisandrin B.
Lam HYP, Liang TR, Peng SY
Nutrients 2023 Apr 15;15(8)
Nutrients 2023 Apr 15;15(8)
3,4-benzopyrene aggravates myocardial ischemia-reperfusion injury-induced pyroptosis through inhibition of autophagy-dependent NLRP3 degradation.
Huang KY, Liu S, Yu YW, Wu BS, Lin ZH, Zhu CX, Song DY, Xue YJ, Ji KT
Ecotoxicology and environmental safety 2023 Apr 1;254:114701
Ecotoxicology and environmental safety 2023 Apr 1;254:114701
Cardiac-specific knockdown of Bhlhe40 attenuates angiotensin II (Ang II)-Induced atrial fibrillation in mice.
Ren KW, Yu XH, Gu YH, Xie X, Wang Y, Wang SH, Li HH, Bi HL
Frontiers in cardiovascular medicine 2022;9:957903
Frontiers in cardiovascular medicine 2022;9:957903
Lactobacillus casei SYF-08 Protects Against Pb-Induced Injury in Young Mice by Regulating Bile Acid Metabolism and Increasing Pb Excretion.
Chen Z, Tang Z, Kong J, Chen L, Liu J, Li Y, Huang W, Li W, Wu J, Zhao W, Meng X, Fan H
Frontiers in nutrition 2022;9:914323
Frontiers in nutrition 2022;9:914323
Long noncoding RNA maternally expressed gene 3 improves trophoblast dysfunction and inflammation in preeclampsia through the Wnt/β-Catenin/nod-like receptor pyrin domain-containing 3 axis.
Liang Y, Wang P, Shi Y, Cui B, Meng J
Frontiers in molecular biosciences 2022;9:1022450
Frontiers in molecular biosciences 2022;9:1022450
Cadmium mediates pyroptosis of human dermal lymphatic endothelial cells in a NLRP3 inflammasome-dependent manner.
Xing H, Liu Q, Hou Y, Tian Z, Liu J
The Journal of toxicological sciences 2022;47(6):237-247
The Journal of toxicological sciences 2022;47(6):237-247
lncRNA IGF2-AS Regulates Nucleotide Metabolism by Mediating HMGA1 to Promote Pyroptosis of Endothelial Progenitor Cells in Sepsis Patients.
Liang G, Zeng M, Gao M, Xing W, Jin X, Wang Q, Deng L, Ou H, He Z
Oxidative medicine and cellular longevity 2022;2022:9369035
Oxidative medicine and cellular longevity 2022;2022:9369035
Betaine Inhibits NLRP3 Inflammasome Hyperactivation and Regulates Microglial M1/M2 Phenotypic Differentiation, Thereby Attenuating Lipopolysaccharide-Induced Depression-Like Behavior.
Zhang M, Wang XL, Shi H, Meng LQ, Quan HF, Yan L, Yang HF, Peng XD
Journal of immunology research 2022;2022:9313436
Journal of immunology research 2022;2022:9313436
Yanghe Pingchuan Granules Alleviate Airway Inflammation in Bronchial Asthma and Inhibit Pyroptosis by Blocking the TLR4/NF-κB/NRLP3 Signaling Pathway.
Pan L, Chen Y, Jiang Y, Sun Y, Han Y, Wang Y
Mediators of inflammation 2022;2022:6561048
Mediators of inflammation 2022;2022:6561048
Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis.
Hong Q, Zhang Y, Lin W, Wang W, Yuan Y, Lin J, Xie Z, Li X, Meng Y
Journal of immunology research 2022;2022:2291877
Journal of immunology research 2022;2022:2291877
Calycosin Alleviates Doxorubicin-Induced Cardiotoxicity and Pyroptosis by Inhibiting NLRP3 Inflammasome Activation.
Zhang L, Fan C, Jiao HC, Zhang Q, Jiang YH, Cui J, Liu Y, Jiang YH, Zhang J, Yang MQ, Li Y, Xue YT
Oxidative medicine and cellular longevity 2022;2022:1733834
Oxidative medicine and cellular longevity 2022;2022:1733834
Lignans from Mosla scabra Ameliorated Influenza A Virus-Induced Pneumonia via Inhibiting Macrophage Activation.
Cai W, Wu LR, Zhang SL
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1688826
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1688826
Yishen Capsule Alleviated Symptoms of Diabetic Nephropathy via NOD-like Receptor Signaling Pathway.
Zhang Z, Hu Y, Liu W, Zhang X, Wang R, Li H, Sun D, Fang J
Diabetes, metabolic syndrome and obesity : targets and therapy 2022;15:2183-2195
Diabetes, metabolic syndrome and obesity : targets and therapy 2022;15:2183-2195
Mfn2 is responsible for inhibition of the RIG-I/IRF7 pathway and activation of NLRP3 inflammasome in Seneca Valley virus-infected PK-15 cells to promote viral replication.
Deng H, Zhu S, Zhu L, Sun J, Ding Y, Li F, Jian Z, Zhao J, Deng L, Deng J, Deng Y, Guo H, Sun X, Lai SY, Tang H, Cui H, Ge LP, Xu Z
Frontiers in immunology 2022;13:955671
Frontiers in immunology 2022;13:955671
Integrated pyroptosis measurement and metabolomics to elucidate the effect and mechanism of tangzhiqing on atherosclerosis.
Chen R, Chen T, Zhou Z, Song Z, Feng W, Yang X, Wang X, Li B, Ding X, Zhang H, Wang Y
Frontiers in physiology 2022;13:937737
Frontiers in physiology 2022;13:937737
NLRP3 downregulation enhances engraftment and functionality of adipose-derived stem cells to alleviate erectile dysfunction in diabetic rats.
Luo C, Peng Y, Zhou X, Fan J, Chen W, Zhang H, Wei A
Frontiers in endocrinology 2022;13:913296
Frontiers in endocrinology 2022;13:913296
Cyclovirobuxine D Ameliorates Experimental Diabetic Cardiomyopathy by Inhibiting Cardiomyocyte Pyroptosis via NLRP3 in vivo and in vitro.
Gao G, Fu L, Xu Y, Tao L, Guo T, Fang G, Zhang G, Wang S, Qin T, Luo P, Shen X
Frontiers in pharmacology 2022;13:906548
Frontiers in pharmacology 2022;13:906548
Protective Effect of Danshen Zexie Decoction Against Non-Alcoholic Fatty Liver Disease Through Inhibition of ROS/NLRP3/IL-1β Pathway by Nrf2 Signaling Activation.
Biao Y, Chen J, Liu C, Wang R, Han X, Li L, Zhang Y
Frontiers in pharmacology 2022;13:877924
Frontiers in pharmacology 2022;13:877924
Neutrophil Extracellular Traps (NETs) Promote Non-Small Cell Lung Cancer Metastasis by Suppressing lncRNA MIR503HG to Activate the NF-κB/NLRP3 Inflammasome Pathway.
Wang Y, Liu F, Chen L, Fang C, Li S, Yuan S, Qian X, Yin Y, Yu B, Fu B, Zhang X, Li Y
Frontiers in immunology 2022;13:867516
Frontiers in immunology 2022;13:867516
Platelet derived growth factor promotes the recovery of traumatic brain injury by inhibiting endoplasmic reticulum stress and autophagy-mediated pyroptosis.
Wu F, Zhang R, Meng W, Liu L, Tang Y, Lu L, Xia L, Zhang H, Feng Z, Chen D
Frontiers in pharmacology 2022;13:862324
Frontiers in pharmacology 2022;13:862324
Succinate/IL-1β Signaling Axis Promotes the Inflammatory Progression of Endothelial and Exacerbates Atherosclerosis.
Xu J, Zheng Y, Zhao Y, Zhang Y, Li H, Zhang A, Wang X, Wang W, Hou Y, Wang J
Frontiers in immunology 2022;13:817572
Frontiers in immunology 2022;13:817572
Nrf2 Signaling Pathway Mediates the Protective Effects of Daphnetin Against D-Galactose Induced-Premature Ovarian Failure.
Zhang M, Yu X, Li D, Ma N, Wei Z, Ci X, Zhang S
Frontiers in pharmacology 2022;13:810524
Frontiers in pharmacology 2022;13:810524
Metformin Inhibits NLR Family Pyrin Domain Containing 3 (NLRP)-Relevant Neuroinflammation via an Adenosine-5'-Monophosphate-Activated Protein Kinase (AMPK)-Dependent Pathway to Alleviate Early Brain Injury After Subarachnoid Hemorrhage in Mice.
Jin L, Jin F, Guo S, Liu W, Wei B, Fan H, Li G, Zhang X, Su S, Li R, Fang D, Duan C, Li X
Frontiers in pharmacology 2022;13:796616
Frontiers in pharmacology 2022;13:796616
Inflammatory-Dependent Bidirectional Effect of Bile Acids on NLRP3 Inflammasome and Its Role in Ameliorating CPT-11-Induced Colitis.
Liao C, Wang D, Qin S, Zhang Y, Chen J, Xu R, Xu F, Zhang P
Frontiers in pharmacology 2022;13:677738
Frontiers in pharmacology 2022;13:677738
Pyroptosis relates to tumor microenvironment remodeling and prognosis: A pan-cancer perspective.
Khan M, Ai M, Du K, Song J, Wang B, Lin J, Ren A, Chen C, Huang Z, Qiu W, Zhang J, Tian Y, Yuan Y
Frontiers in immunology 2022;13:1062225
Frontiers in immunology 2022;13:1062225
Corilagin alleviates intestinal ischemia/reperfusion-induced intestinal and lung injury in mice via inhibiting NLRP3 inflammasome activation and pyroptosis.
Li W, Yang K, Li B, Wang Y, Liu J, Chen D, Diao Y
Frontiers in pharmacology 2022;13:1060104
Frontiers in pharmacology 2022;13:1060104
Administration of USP7 inhibitor P22077 inhibited cardiac hypertrophy and remodeling in Ang II-induced hypertensive mice.
Gu YH, Ren KW, Wang Y, Wang SH, Yu XH, Xu LW, Li HH, Bi HL
Frontiers in pharmacology 2022;13:1021361
Frontiers in pharmacology 2022;13:1021361
Identification of pyroptosis-related lncRNA signature and AC005253.1 as a pyroptosis-related oncogene in prostate cancer.
Yu J, Tang R, Li J
Frontiers in oncology 2022;12:991165
Frontiers in oncology 2022;12:991165
PINK1-Dependent Mitophagy Reduced Endothelial Hyperpermeability and Cell Migration Capacity Under Simulated Microgravity.
Li C, Pan Y, Tan Y, Wang Y, Sun X
Frontiers in cell and developmental biology 2022;10:896014
Frontiers in cell and developmental biology 2022;10:896014
Mechanical Stimulation Protects Against Chondrocyte Pyroptosis Through Irisin-Induced Suppression of PI3K/Akt/NF-κB Signal Pathway in Osteoarthritis.
Jia S, Yang Y, Bai Y, Wei Y, Zhang H, Tian Y, Liu J, Bai L
Frontiers in cell and developmental biology 2022;10:797855
Frontiers in cell and developmental biology 2022;10:797855
Biomimetic Metal-Organic Framework Nanoparticles for Synergistic Combining of SDT-Chemotherapy Induce Pyroptosis in Gastric Cancer.
Yu Z, Cao W, Han C, Wang Z, Qiu Y, Wang J, Wei M, Wang J, Zhang S, Liu S, Mo S, Chen J
Frontiers in bioengineering and biotechnology 2022;10:796820
Frontiers in bioengineering and biotechnology 2022;10:796820
Mechanism of nonylphenol induced gastric inflammation through NF-κB/NLRP3 signaling pathway.
Xu J, Li S, Yang X, Wang H, Ma L, Shen Y, Yu J
Toxicology 2022 Sep;479:153294
Toxicology 2022 Sep;479:153294
Salvianolic Acid B Alleviates Myocardial Ischemia Injury by Suppressing NLRP3 Inflammasome Activation via SIRT1-AMPK-PGC-1α Signaling Pathway.
Li Q, Zuo Z, Pan Y, Zhang Q, Xu L, Jiang B
Cardiovascular toxicology 2022 Sep;22(9):842-857
Cardiovascular toxicology 2022 Sep;22(9):842-857
MicroRNA-223 downregulation promotes HBx-induced podocyte pyroptosis by targeting the NLRP3 inflammasome.
Yu Y, Dong H, Zhang Y, Sun J, Li B, Chen Y, Feng M, Yang X, Gao S, Jiang W
Archives of virology 2022 Sep;167(9):1841-1854
Archives of virology 2022 Sep;167(9):1841-1854
Aqueous extract of Scrophularia ningpoensis improves insulin sensitivity through AMPK-mediated inhibition of the NLRP3 inflammasome.
Yan S, Lu W, Zhou J, Guo X, Li J, Cheng H, Zhu X, Zhao Y, Duan M, Yang H, Zhang Y, Wang Q, Chen L, Zheng T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154308
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154308
Lactobacillus rhamnosus GR-1 attenuates foodborne Bacillus cereus-induced NLRP3 inflammasome activity in bovine mammary epithelial cells by protecting intercellular tight junctions.
Shan Q, Liu N, Wang X, Zhu Y, Yin J, Wang J
Journal of animal science and biotechnology 2022 Sep 9;13(1):101
Journal of animal science and biotechnology 2022 Sep 9;13(1):101
Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway.
Li X, Zhou X, Liu X, Li X, Jiang X, Shi B, Wang S
Molecular medicine (Cambridge, Mass.) 2022 Sep 4;28(1):103
Molecular medicine (Cambridge, Mass.) 2022 Sep 4;28(1):103
The role of proteoglycan form of DMP1 in cranial repair.
Liu Y, Niu P, Zhou M, Xue H
BMC molecular and cell biology 2022 Sep 30;23(1):43
BMC molecular and cell biology 2022 Sep 30;23(1):43
Itaconate Attenuates Neuroinflammation and Exerts Dopamine Neuroprotection in Parkinson's Disease through Inhibiting NLRP3 Inflammasome.
Sun G, Zhang R, Liu C, Meng W, Pang Q
Brain sciences 2022 Sep 16;12(9)
Brain sciences 2022 Sep 16;12(9)
Anti-inflammatory potential of stevia residue extract against uric acid-associated renal injury in mice.
Mehmood A, Althobaiti F, Zhao L, Usman M, Chen X, Alharthi F, Soliman MM, Shah AA, Murtaza MA, Nadeem M, Ranjha MMAN, Wang C
Journal of food biochemistry 2022 Oct;46(10):e14286
Journal of food biochemistry 2022 Oct;46(10):e14286
ALPK1 Accelerates the Pathogenesis of Osteoarthritis by Activating NLRP3 Signaling.
Liu X, Zhao J, Jiang H, Guo H, Li Y, Li H, Feng Y, Ke J, Long X
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Oct;37(10):1973-1985
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Oct;37(10):1973-1985
Substance P promotes the progression of bronchial asthma through activating the PI3K/AKT/NF-κB pathway mediated cellular inflammation and pyroptotic cell death in bronchial epithelial cells.
Li M, Zhong X, Xu WT
Cell cycle (Georgetown, Tex.) 2022 Oct;21(20):2179-2191
Cell cycle (Georgetown, Tex.) 2022 Oct;21(20):2179-2191
VCAM-1-binding peptide targeted cationic liposomes containing NLRP3 siRNA to modulate LDL transcytosis as a novel therapy for experimental atherosclerosis.
Jia X, Bai X, Yang X, Wang L, Lu Y, Zhu L, Zhao Y, Cheng W, Shu M, Mei Q, Jin S
Metabolism: clinical and experimental 2022 Oct;135:155274
Metabolism: clinical and experimental 2022 Oct;135:155274
Bisdemethoxycurcumin Alleviates Dextran Sodium Sulfate-Induced Colitis via Inhibiting NLRP3 Inflammasome Activation and Modulating the Gut Microbiota in Mice.
Zhang J, Li Q, Zhang X, Chen Y, Lu Y, Wang X, Zhang L, Wang T
Antioxidants (Basel, Switzerland) 2022 Oct 7;11(10)
Antioxidants (Basel, Switzerland) 2022 Oct 7;11(10)
Z. morio Hemolymph Relieves E. coli-Induced Mastitis by Inhibiting Inflammatory Response and Repairing the Blood-Milk Barrier.
Zou Y, Wang X, Xu J, Wang S, Li S, Zhu Y, Wang J
International journal of molecular sciences 2022 Oct 31;23(21)
International journal of molecular sciences 2022 Oct 31;23(21)
MicroRNA-25-5p negatively regulates TXNIP expression and relieves inflammatory responses of brain induced by lipopolysaccharide.
Wang J, Ye Z, Chen Y, Qiao X, Jin Y
Scientific reports 2022 Oct 26;12(1):17915
Scientific reports 2022 Oct 26;12(1):17915
Crucial Function of Caveolin-1 in Deoxynivalenol-Induced Enterotoxicity by Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis.
Qu J, Zhang S, He W, Liu S, Mao X, Yin L, Yue D, Zhang P, Huang K, Chen X
Journal of agricultural and food chemistry 2022 Oct 12;70(40):12968-12981
Journal of agricultural and food chemistry 2022 Oct 12;70(40):12968-12981
Reactive Oxygen Species Contributes to Type 2 Diabetic Neuropathic Pain via the Thioredoxin-Interacting Protein-NOD-Like Receptor Protein 3- N -Methyl-D-Aspartic Acid Receptor 2B Pathway.
Wang JW, Ye XY, Wei N, Wu SS, Zhang ZH, Luo GH, Li X, Li J, Cao H
Anesthesia and analgesia 2022 Oct 1;135(4):865-876
Anesthesia and analgesia 2022 Oct 1;135(4):865-876
Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.
Zhao AN, Yang Z, Wang DD, Shi B, Zhang H, Bai Y, Yan BW, Zhang Y, Wen JK, Wang XL, Qu CB
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22602
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22602
Effect of Curcumol on NOD-Like Receptor Thermoprotein Domain 3 Inflammasomes in Liver Fibrosis of Mice.
Zheng Y, Wang L, Wang JH, Liu LL, Zhao TJ
Chinese journal of integrative medicine 2022 Nov;28(11):992-999
Chinese journal of integrative medicine 2022 Nov;28(11):992-999
Taraxasterol inhibits inflammation in osteoarthritis rat model by regulating miRNAs and NF-κB signaling pathway.
Xie Z, Wang B, Zheng C, Qu Y, Xu J, Wang B, Gao Y, Shen P
Acta biochimica Polonica 2022 Nov 26;69(4):811-818
Acta biochimica Polonica 2022 Nov 26;69(4):811-818
Sophocarpine Alleviates Isoproterenol-Induced Kidney Injury by Suppressing Inflammation, Apoptosis, Oxidative Stress and Fibrosis.
Zhou W, Fu Y, Xu JS
Molecules (Basel, Switzerland) 2022 Nov 15;27(22)
Molecules (Basel, Switzerland) 2022 Nov 15;27(22)
Neutrophil Extracellular Traps Mediate Bovine Endometrial Epithelial Cell Pyroptosis in Dairy Cows with Endometritis.
Shen W, Ma X, Shao D, Wu X, Wang S, Zheng J, Lv Y, Ding X, Ma B, Yan Z
International journal of molecular sciences 2022 Nov 13;23(22)
International journal of molecular sciences 2022 Nov 13;23(22)
S100A8-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Macrophages Facilitates Liver Fibrosis Progression.
Liu Y, Kong X, You Y, Xiang L, Zhang Y, Wu R, Zhou L, Duan L
Cells 2022 Nov 12;11(22)
Cells 2022 Nov 12;11(22)
Inhibition of miR-423-5p Exerts Neuroprotective Effects in an Experimental Rat Model of Cerebral Ischemia/Reperfusion Injury.
Luo J, Jiang N, Chen J, Yu G, Zhao J, Yang C, Zhao Y
Neuroscience 2022 Nov 1;503:95-106
Neuroscience 2022 Nov 1;503:95-106
The role of discoid domain receptor 1 on renal tubular epithelial pyroptosis in diabetic nephropathy.
Zhao W, He C, Jiang J, Zhao Z, Yuan H, Wang F, Shen B
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2022 Nov 1;26(6):427-438
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2022 Nov 1;26(6):427-438
Past Exposure to Cigarette Smoke Aggravates Cognitive Impairment in a Rat Model of Vascular Dementia via Neuroinflammation.
Meng N, Dong Y, Huo T, Song M, Jiang X, Xiao Y, Lv P
Cellular and molecular neurobiology 2022 May;42(4):1021-1034
Cellular and molecular neurobiology 2022 May;42(4):1021-1034
Ghrelin ameliorates diabetes-associated behavioral deficits and NLRP3 inflammasome activation via autophagic flux enhancement.
Han W, Cui C, Zhang H, Guo Y, Xie D, Zhang W, Wang C, Yang M, Jiang P
Pharmacological research 2022 May;179:106224
Pharmacological research 2022 May;179:106224
BtpB inhibits innate inflammatory responses in goat alveolar macrophages through the TLR/NF-κB pathway and NLRP3 inflammasome during Brucella infection.
Li J, Zhang G, Zhi F, Zhai Y, Zhou D, Chen H, Lin P, Tang K, Liu W, Jin Y, Wang A
Microbial pathogenesis 2022 May;166:105536
Microbial pathogenesis 2022 May;166:105536
GPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome.
Qin Z, Song J, Lin A, Yang W, Zhang W, Zhong F, Huang L, Lü Y, Yu W
Journal of neuroinflammation 2022 May 27;19(1):121
Journal of neuroinflammation 2022 May 27;19(1):121
Apigenin alleviated PA-induced pyroptosis by activating autophagy in hepatocytes.
Meng Z, Zhu B, Gao M, Wang G, Zhou H, Lu J, Guan S
Food & function 2022 May 23;13(10):5559-5570
Food & function 2022 May 23;13(10):5559-5570
An Experimental Study Reveals the Protective Effect of Autophagy against Realgar-Induced Liver Injury via Suppressing ROS-Mediated NLRP3 Inflammasome Pathway.
Yang J, Li J, Guo H, Zhang Y, Guo Z, Liu Y, Huo T
International journal of molecular sciences 2022 May 19;23(10)
International journal of molecular sciences 2022 May 19;23(10)
NLRP3 inflammasome as a key molecular target underlying cognitive resilience in amyotrophic lateral sclerosis.
Banerjee P, Elliott E, Rifai OM, O'Shaughnessy J, McDade K, Abrahams S, Chandran S, Smith C, Gregory JM
The Journal of pathology 2022 Mar;256(3):262-268
The Journal of pathology 2022 Mar;256(3):262-268
Galectin-3 enhances atrial remodelling and arrhythmogenesis through CD98 signalling.
Cheng WL, Chen YC, Li SJ, Lee TI, Lee TW, Higa S, Chung CC, Kao YH, Chen SA, Chen YJ
Acta physiologica (Oxford, England) 2022 Mar;234(3):e13784
Acta physiologica (Oxford, England) 2022 Mar;234(3):e13784
Platonin protects against cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasomes via BNIP3/LC3 signaling mediated autophagy.
Luo J, Tan J, Jiang N, Yang C, Chen J, Zhao J, Li L, Zhao Y
Brain research bulletin 2022 Mar;180:12-23
Brain research bulletin 2022 Mar;180:12-23
Effectiveness of NLRP3 Inhibitor as a Non-Hormonal Treatment for ovarian endometriosis.
Murakami M, Osuka S, Muraoka A, Hayashi S, Bayasula, Kasahara Y, Sonehara R, Hariyama Y, Shinjo K, Tanaka H, Miyake N, Yoshita S, Nakanishi N, Nakamura T, Goto M, Kajiyama H
Reproductive biology and endocrinology : RB&E 2022 Mar 29;20(1):58
Reproductive biology and endocrinology : RB&E 2022 Mar 29;20(1):58
Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction.
Wang H, Lv D, Jiang S, Hou Q, Zhang L, Li S, Zhu X, Xu X, Wen J, Zeng C, Zhang M, Yang F, Chen Z, Zheng C, Li J, Zen K, Liu Z, Li L
Cell death & disease 2022 Mar 29;13(3):281
Cell death & disease 2022 Mar 29;13(3):281
The role of α5-nicotinic acetylcholine receptor/NLRP3 signaling pathway in lung adenocarcinoma cell proliferation and migration.
Jia Y, Zhang Q, Liu Z, Pan P, Jia Y, Zhu P, Jiao Y, Kang G, Ma X
Toxicology 2022 Mar 15;469:153120
Toxicology 2022 Mar 15;469:153120
Curcumin improves the function of umbilical vein endothelial cells by inhibiting H(2)O(2)‑induced pyroptosis.
Yuan Y, Zhang C, He Y, Yuan L, Zhao Q, Liu Y, Long S
Molecular medicine reports 2022 Jun;25(6)
Molecular medicine reports 2022 Jun;25(6)
MicroRNA-200c-5p targets NIMA Related Kinase 7 (NEK7) to inhibit NOD-like receptor 3 (NLRP3) inflammasome activation, MODE-K cell pyroptosis, and inflammatory bowel disease in mice.
Wu G, Zhang D, Yang L, Wu Q, Yuan L
Molecular immunology 2022 Jun;146:57-68
Molecular immunology 2022 Jun;146:57-68
SIRT1 alleviates IL-1β induced nucleus pulposus cells pyroptosis via mitophagy in intervertebral disc degeneration.
Ma Z, Tang P, Dong W, Lu Y, Tan B, Zhou N, Hao J, Shen J, Hu Z
International immunopharmacology 2022 Jun;107:108671
International immunopharmacology 2022 Jun;107:108671
MicroRNA-223-3p promotes pyroptosis of cardiomyocyte and release of inflammasome factors via downregulating the expression level of SPI1 (PU.1).
Zhao S, Tan Y, Qin J, Xu H, Liu L, Wan H, Zhang C, Fan W, Qu S
Toxicology 2022 Jun 30;476:153252
Toxicology 2022 Jun 30;476:153252
Ambient particulate matter exposure plus a high-fat diet exacerbate renal injury by activating the NLRP3 inflammasome and TGF-β1/Smad2 signaling pathway in mice.
Jiang J, Ding S, Zhang G, Dong Y
Ecotoxicology and environmental safety 2022 Jun 15;238:113571
Ecotoxicology and environmental safety 2022 Jun 15;238:113571
Ethyl carbamate triggers ferroptosis in liver through inhibiting GSH synthesis and suppressing Nrf2 activation.
Xu Y, Li Y, Li J, Chen W
Redox biology 2022 Jul;53:102349
Redox biology 2022 Jul;53:102349
Icariin attenuates ischaemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signalling pathway in rats.
Zheng J, Liao Y, Xu Y, Mo Z
Clinical and experimental pharmacology & physiology 2022 Jul;49(7):719-730
Clinical and experimental pharmacology & physiology 2022 Jul;49(7):719-730
Neuroprotective effects of CysLTR antagonist on Streptococcus pneumoniae-induced meningitis in rats.
Yu S, Chen X, Li X, Yan J, Jiang Y
Experimental and therapeutic medicine 2022 Jul;24(1):443
Experimental and therapeutic medicine 2022 Jul;24(1):443
Enhanced Extracellular Matrix Degradation in Growth Plate Contributes to Manganese Deficiency-Induced Tibial Dyschondroplasia in Broiler Chicks.
Dong PF, Jin C, Lian CY, Wang L, Wang ZY
Biological trace element research 2022 Jul;200(7):3326-3335
Biological trace element research 2022 Jul;200(7):3326-3335
Procyanidins and its metabolites by gut microbiome improves insulin resistance in gestational diabetes mellitus mice model via regulating NF-κB and NLRP3 inflammasome pathway.
Liu Y, Sun R, Lin X, Wu L, Chen H, Shen S, Li Y, Wei Y, Deng G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113078
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113078
3,4,5-O-tricaffeoylquinic acid with anti-radiation activity suppresses LPS-induced NLRP3 inflammasome activation via autophagy in THP-1 macrophages.
Liu J, Chen J, Xu B, Lin L, Liu S, Ma X, Liu J
Molecular immunology 2022 Jul;147:187-198
Molecular immunology 2022 Jul;147:187-198
Preconditioning with procyanidin B2 protects MAC-T cells against heat exposure-induced mitochondrial dysfunction and inflammation.
Wang H, Hao W, Yang L, Yan P, Wei S
Molecular immunology 2022 Jul;147:126-135
Molecular immunology 2022 Jul;147:126-135
Inhibition of semaphorin-3a alleviates lipopolysaccharide-induced vascular injury.
Fu Y, Liu JW, Wu J, Wu ZX, Li J, Ji HF, Liang NP, Zhang HJ, Lai ZQ, Dong YF
Microvascular research 2022 Jul;142:104346
Microvascular research 2022 Jul;142:104346
mTOR-Mediated Autophagy Regulates Fumonisin B(1)-Induced Intestinal Inflammation via Pyroptosis In Vivo and In Vitro.
Mao X, Liu S, Ge L, Du H, Yue D, Hou L, Huang K, Chen X
Journal of agricultural and food chemistry 2022 Jul 27;70(29):9187-9200
Journal of agricultural and food chemistry 2022 Jul 27;70(29):9187-9200
CysLT(2)R Antagonist HAMI 3379 Ameliorates Post-Stroke Depression through NLRP3 Inflammasome/Pyroptosis Pathway in Gerbils.
Zhou L, Zhang J, Han X, Fang J, Zhou S, Lu L, Shi Q, Ying H
Brain sciences 2022 Jul 24;12(8)
Brain sciences 2022 Jul 24;12(8)
Resolvin D1 Alleviates Mechanical Allodynia via ALX/FPR2 Receptor Targeted Nod-like Receptor Protein 3/Extracellular Signal-Related Kinase Signaling in a Neuropathic Pain Model.
Wang YH, Gao X, Tang YR, Chen FQ, Yu Y, Sun MJ, Li Y
Neuroscience 2022 Jul 1;494:12-24
Neuroscience 2022 Jul 1;494:12-24
Bryodulcosigenin a natural cucurbitane-type triterpenoid attenuates dextran sulfate sodium (DSS)-induced colitis in mice.
Li R, Chen C, Liu B, Shi W, Shimizu K, Zhang C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;94:153814
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;94:153814
H. pylori CagA activates the NLRP3 inflammasome to promote gastric cancer cell migration and invasion.
Zhang X, Li C, Chen D, He X, Zhao Y, Bao L, Wang Q, Zhou J, Xie Y
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022 Jan;71(1):141-155
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022 Jan;71(1):141-155
Hepatitis B virus X mediates podocyte pyroptosis by regulating the ROS/NLRP3 signaling pathway in hepatitis B virus-associated glomerulonephritis.
Yu Y, Dong H, Sun J, Li B, Chen Y, Feng M, Yang X, Jiang W
Iranian journal of basic medical sciences 2022 Jan;25(1):103-109
Iranian journal of basic medical sciences 2022 Jan;25(1):103-109
Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.
Zhou GQ, Chen G, Yang J, Qin WY, Ping J
Journal of ethnopharmacology 2022 Jan 30;283:114707
Journal of ethnopharmacology 2022 Jan 30;283:114707
The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB.
Xu LT, Wang T, Fang KL, Zhao Y, Wang XN, Ren DM, Shen T
Journal of ethnopharmacology 2022 Jan 30;283:114694
Journal of ethnopharmacology 2022 Jan 30;283:114694
Pulsed electromagnetic field alleviates synovitis and inhibits the NLRP3/Caspase-1/GSDMD signaling pathway in osteoarthritis rats.
Liu J, Huang X, Zhou J, Li L, Xiao H, Qu M, Sun Z
Electromagnetic biology and medicine 2022 Jan 2;41(1):101-107
Electromagnetic biology and medicine 2022 Jan 2;41(1):101-107
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
Li W, Huang BS, Xiong YY, Yang LJ, Wu LX
Cancer cell international 2022 Jan 18;22(1):32
Cancer cell international 2022 Jan 18;22(1):32
Lactobacillus rhamnosus Ameliorates Multi-Drug-Resistant Bacillus cereus-Induced Cell Damage through Inhibition of NLRP3 Inflammasomes and Apoptosis in Bovine Endometritis.
Liu N, Wang X, Shan Q, Xu L, Li Y, Chu B, Yang L, Wang J, Zhu Y
Microorganisms 2022 Jan 10;10(1)
Microorganisms 2022 Jan 10;10(1)
The Role of NF-κB/NLRP3 Inflammasome Signaling Pathway in Attenuating Pyroptosis by Melatonin Upon Spinal Nerve Ligation Models.
Wang YH, Gao X, Tang YR, Yu Y, Sun MJ, Chen FQ, Li Y
Neurochemical research 2022 Feb;47(2):335-346
Neurochemical research 2022 Feb;47(2):335-346
Crosstalk Between RPE Cells and Choroidal Endothelial Cells via the ANXA1/FPR2/SHP2/NLRP3 Inflammasome/Pyroptosis Axis Promotes Choroidal Neovascularization.
Zhu M, Wang Y, Zhu L, Du S, Wang Z, Zhang Y, Guo Y, Tu Y, Song E
Inflammation 2022 Feb;45(1):414-427
Inflammation 2022 Feb;45(1):414-427
Alliin alleviates LPS-induced pyroptosis via promoting mitophagy in THP-1 macrophages and mice.
Liu M, Lu J, Yang S, Chen Y, Yu J, Guan S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Feb;160:112811
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Feb;160:112811
Effect of nonylphenol on the colonic mucosa in rats and intervention with zinc-selenium green tea (Camellia sinensis).
Li S, Zheng M, Yang X, Zhang J, Xu J, Yu J
Toxicology research 2022 Feb;11(1):122-133
Toxicology research 2022 Feb;11(1):122-133
Development of a prognostic pyroptosis-related gene signature for head and neck squamous cell carcinoma patient.
Zhu W, Zhang J, Wang M, Zhai R, Xu Y, Wang J, Wang M, Zhang H, Liu L
Cancer cell international 2022 Feb 5;22(1):62
Cancer cell international 2022 Feb 5;22(1):62
Autophagy-based unconventional secretion of HMGB1 in glioblastoma promotes chemosensitivity to temozolomide through macrophage M1-like polarization.
Li Z, Fu WJ, Chen XQ, Wang S, Deng RS, Tang XP, Yang KD, Niu Q, Zhou H, Li QR, Lin Y, Liang M, Li SS, Ping YF, Liu XD, Bian XW, Yao XH
Journal of experimental & clinical cancer research : CR 2022 Feb 22;41(1):74
Journal of experimental & clinical cancer research : CR 2022 Feb 22;41(1):74
Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways.
Zhang L, Zhu XZ, Badamjav R, Zhang JZ, Kou JP, Yu BY, Li F
European journal of pharmacology 2022 Feb 15;917:174748
European journal of pharmacology 2022 Feb 15;917:174748
Jinlida granules ameliorate the high-fat-diet induced liver injury in mice by antagonising hepatocytes pyroptosis.
Hao YY, Cui WW, Gao HL, Wang MY, Liu Y, Li CR, Hou YL, Jia ZH
Pharmaceutical biology 2022 Dec;60(1):274-281
Pharmaceutical biology 2022 Dec;60(1):274-281
ATG5-Mediated Autophagy May Inhibit Pyroptosis to Ameliorate Oleic Acid-Induced Hepatocyte Steatosis.
Tang Q, Liu W, Yang X, Tian Y, Chen J, Hu Y, Fu N
DNA and cell biology 2022 Dec;41(12):1038-1052
DNA and cell biology 2022 Dec;41(12):1038-1052
Сyclooxygenase-2 Inhibitor Parecoxib Reduces LPS-Induced Activation of BV2 Microglia Cells.
Li X, Zhou JX, Qu YD, Kuang X
Bulletin of experimental biology and medicine 2022 Dec;174(2):210-215
Bulletin of experimental biology and medicine 2022 Dec;174(2):210-215
Identification of key proteins of cytopathic biotype bovine viral diarrhoea virus involved in activating NF-κB pathway in BVDV-induced inflammatory response.
Fan W, Wang Y, Jiang S, Li Y, Yao X, Wang M, Zhao J, Sun X, Jiang X, Zhong L, Han Y, Song H, Xu Y
Virulence 2022 Dec;13(1):1884-1899
Virulence 2022 Dec;13(1):1884-1899
FGF5 protects heart from sepsis injury by attenuating cardiomyocyte pyroptosis through inhibiting CaMKII/NFκB signaling.
Cui S, Li Y, Zhang X, Wu B, Li M, Gao J, Xia H, Xu L
Biochemical and biophysical research communications 2022 Dec 25;636(Pt 2):104-112
Biochemical and biophysical research communications 2022 Dec 25;636(Pt 2):104-112
Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Targeting the Gut Microbiota Accompanied by the TLR4/NF-κB/NLRP3 Cascade Response In Vivo.
Xia X, Lin H, Luo F, Wu X, Zhu L, Chen S, Luo H, Ye F, Peng X, Zhang Y, Yang G, Lin Q
Journal of agricultural and food chemistry 2022 Dec 21;70(50):15747-15762
Journal of agricultural and food chemistry 2022 Dec 21;70(50):15747-15762
FGF5 alleviated acute lung injury via AKT signal pathway in endothelial cells.
Li Y, Cui S, Wu B, Gao J, Li M, Zhang F, Xia H
Biochemical and biophysical research communications 2022 Dec 17;634:152-158
Biochemical and biophysical research communications 2022 Dec 17;634:152-158
The selective NLRP3 inflammasome inhibitor MCC950 improves isoproterenol-induced cardiac dysfunction by inhibiting cardiomyocyte senescence.
Shi Y, Zhao L, Wang J, Liu S, Zhang Y, Qin Q
European journal of pharmacology 2022 Dec 15;937:175364
European journal of pharmacology 2022 Dec 15;937:175364
Treadmill training mitigates bone deterioration via inhibiting NLRP3/Caspase1/IL-1β signaling in aged rats.
Wu Q, Zhong P, Ning P, Tan L, Huang X, Peng T, Yin L, Luo F, Qu M, Zhou J
BMC musculoskeletal disorders 2022 Dec 13;23(1):1089
BMC musculoskeletal disorders 2022 Dec 13;23(1):1089
Inhibited transcription factor EB function induces reactive oxygen species overproduction to promote pyroptosis in cadmium-exposed renal tubular epithelial cells.
Dong PF, Li ZF, Lian CY, Wang ZY, Wang L
Chemico-biological interactions 2022 Dec 1;368:110249
Chemico-biological interactions 2022 Dec 1;368:110249
Effects of resveratrol and its derivative pterostilbene on hepatic injury and immunological stress of weaned piglets challenged with lipopolysaccharide.
Li Y, Zhang H, Tu F, Cao J, Hou X, Chen Y, Yan J
Journal of animal science 2022 Dec 1;100(12)
Journal of animal science 2022 Dec 1;100(12)
Ubiquitin-specific protease 47 regulates intestinal inflammation through deubiquitination of TRAF6 in epithelial cells.
Lei H, Yang L, Xu H, Wang Z, Li X, Liu M, Wu Y
Science China. Life sciences 2022 Aug;65(8):1624-1635
Science China. Life sciences 2022 Aug;65(8):1624-1635
Bacillus subtilis WB800N alleviates diabetic wounds in mice by regulating gut microbiota homeostasis and TLR2.
Mi J, Xie C, Zeng L, Zhu Z, Chen N, He Q, Xu X, Xie H, Zhou J, Li L, Liao J
Journal of applied microbiology 2022 Aug;133(2):436-447
Journal of applied microbiology 2022 Aug;133(2):436-447
Paeoniflorin ameliorates diabetic liver injury by targeting the TXNIP-mediated NLRP3 inflammasome in db/db mice.
Wang A, Gong Y, Pei Z, Jiang L, Xia L, Wu Y
International immunopharmacology 2022 Aug;109:108792
International immunopharmacology 2022 Aug;109:108792
Rhodiola crenulate alleviates hypobaric hypoxia-induced brain injury via adjusting NF-κB/NLRP3-mediated inflammation.
Xie N, Fan F, Jiang S, Hou Y, Zhang Y, Cairang N, Wang X, Meng X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Aug;103:154240
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Aug;103:154240
Mucin O-glycan-microbiota axis orchestrates gut homeostasis in a diarrheal pig model.
Xia B, Zhong R, Wu W, Luo C, Meng Q, Gao Q, Zhao Y, Chen L, Zhang S, Zhao X, Zhang H
Microbiome 2022 Aug 31;10(1):139
Microbiome 2022 Aug 31;10(1):139
Forsythiaside A Improves the Inhibitory Efficiency of Recombinant Protein Vaccines against Bovine Viral Diarrhea Virus Infection.
Yang G, Wang J, Wang S, Zhu Y
International journal of molecular sciences 2022 Aug 20;23(16)
International journal of molecular sciences 2022 Aug 20;23(16)
Anti-depressant effects of acupuncture: The insights from NLRP3 mediated pyroptosis and inflammation.
Chen Y, Hao C, Chen W, Cheng W, Li P, Shen J, Tong T, Yan S, Huang S, He T, Huang Z, Meng X
Neuroscience letters 2022 Aug 10;785:136787
Neuroscience letters 2022 Aug 10;785:136787
Resolution of systemic complications in Schistosoma mansoni-infected mice by concomitant treatment with praziquantel and Schisandrin B.
Lam HYP, Cheng PC, Peng SY
International journal for parasitology 2022 Apr;52(5):275-284
International journal for parasitology 2022 Apr;52(5):275-284
Alda-1, an Activator of ALDH2, Improves Postresuscitation Cardiac and Neurological Outcomes by Inhibiting Pyroptosis in Swine.
Diao M, Xu J, Wang J, Zhang M, Wu C, Hu X, Zhu Y, Zhang M, Hu W
Neurochemical research 2022 Apr;47(4):1097-1109
Neurochemical research 2022 Apr;47(4):1097-1109
Ginsenoside Rd attenuates cerebral ischemia/reperfusion injury by exerting an anti-pyroptotic effect via the miR-139-5p/FoxO1/Keap1/Nrf2 axis.
Yao Y, Hu S, Zhang C, Zhou Q, Wang H, Yang Y, Liu C, Ding H
International immunopharmacology 2022 Apr;105:108582
International immunopharmacology 2022 Apr;105:108582
Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice.
Song Z, Wang L, Cao Y, Liu Z, Zhang M, Zhang Z, Jiang S, Fan R, Hao T, Yang R, Wang B, Guan Z, Zhu L, Liu Z, Zhang S, Zhao L, Xu Z, Xu H, Dai G
International immunopharmacology 2022 Apr;105:108539
International immunopharmacology 2022 Apr;105:108539
Tubastatin A Improves Post-Resuscitation Myocardial Dysfunction by Inhibiting NLRP3-Mediated Pyroptosis Through Enhancing Transcription Factor EB Signaling.
Xu J, Zhao X, Jiang X, He L, Wu X, Wang J, Chen Q, Li Y, Zhang M
Journal of the American Heart Association 2022 Apr 5;11(7):e024205
Journal of the American Heart Association 2022 Apr 5;11(7):e024205
ATP6AP2 knockdown in cardiomyocyte deteriorates heart function via compromising autophagic flux and NLRP3 inflammasome activation.
Li L, Cui YJ, Liu Y, Li HX, Su YD, Li SN, Wang LL, Zhao YW, Wang SX, Yan F, Dong B
Cell death discovery 2022 Apr 4;8(1):161
Cell death discovery 2022 Apr 4;8(1):161
Platycodon grandiflorum root fermentation broth reduces inflammation in a mouse IBD model through the AMPK/NF-κB/NLRP3 pathway.
Wang Z, Li C, He X, Xu K, Xue Z, Wang T, Xu Z, Liu X
Food & function 2022 Apr 4;13(7):3946-3956
Food & function 2022 Apr 4;13(7):3946-3956
Dietary Tryptophan Supplementation Improves Antioxidant Status and Alleviates Inflammation, Endoplasmic Reticulum Stress, Apoptosis, and Pyroptosis in the Intestine of Piglets after Lipopolysaccharide Challenge.
Liu G, Tao J, Lu J, Jia G, Zhao H, Chen X, Tian G, Cai J, Zhang R, Wang J
Antioxidants (Basel, Switzerland) 2022 Apr 28;11(5)
Antioxidants (Basel, Switzerland) 2022 Apr 28;11(5)
PPT1 Reduction Contributes to Erianin-Induced Growth Inhibition in Oral Squamous Carcinoma Cells.
Luo Q, Li X, Gan G, Yang M, Chen X, Chen F
Frontiers in cell and developmental biology 2021;9:764263
Frontiers in cell and developmental biology 2021;9:764263
The Ferroptosis-NLRP1 Inflammasome: The Vicious Cycle of an Adverse Pregnancy.
Meihe L, Shan G, Minchao K, Xiaoling W, Peng A, Xili W, Jin Z, Huimin D
Frontiers in cell and developmental biology 2021;9:707959
Frontiers in cell and developmental biology 2021;9:707959
Caspase-1 Inhibitor Reduces Pyroptosis Induced by Brain Death in Kidney.
Liu W, Yang D, Shi J, Wen P, Zhang J, Wang Z, Hu B, Shi X, Cao S, Guo W, Zhang S
Frontiers in surgery 2021;8:760989
Frontiers in surgery 2021;8:760989
Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway.
Zhang Q, Zhao C, Zhang L, Sun K, Yu L, Wang X, Ren L, Zhang N, Chen C, Liu J, Wang H, Tian H
Oxidative medicine and cellular longevity 2021;2021:9921839
Oxidative medicine and cellular longevity 2021;2021:9921839
Si-Miao-Yong-An Decoction Maintains the Cardiac Function and Protects Cardiomyocytes from Myocardial Ischemia and Reperfusion Injury.
Cui W, Xin S, Zhu L, Wang M, Hao Y, Zhao Y, Li Y, Hou Y
Evidence-based complementary and alternative medicine : eCAM 2021;2021:8968464
Evidence-based complementary and alternative medicine : eCAM 2021;2021:8968464
P2X7 Receptor Induces Pyroptotic Inflammation and Cartilage Degradation in Osteoarthritis via NF-κB/NLRP3 Crosstalk.
Li Z, Huang Z, Zhang H, Lu J, Tian Y, Wei Y, Yang Y, Bai L
Oxidative medicine and cellular longevity 2021;2021:8868361
Oxidative medicine and cellular longevity 2021;2021:8868361
Moxibustion Ameliorates Ovarian Reserve in Rats by Mediating Nrf2/HO-1/NLRP3 Anti-Inflammatory Pathway.
Lu G, Wang Q, Xie ZJ, Liang SJ, Li HX, Shi L, Li Q, Shen J, Cheng J, Shen MH
Evidence-based complementary and alternative medicine : eCAM 2021;2021:8817858
Evidence-based complementary and alternative medicine : eCAM 2021;2021:8817858
Antioral Squamous Cell Carcinoma Effects of Carvacrol via Inhibiting Inflammation, Proliferation, and Migration Related to Nrf2/Keap1 Pathway.
Liu H, Xu X, Wu R, Bi L, Zhang C, Chen H, Yang Y
BioMed research international 2021;2021:6616547
BioMed research international 2021;2021:6616547
Tongxinluo Exerts Inhibitory Effects on Pyroptosis and Amyloid-β Peptide Accumulation after Cerebral Ischemia/Reperfusion in Rats.
Wang B, Lyu Z, Chan Y, Li Q, Zhang L, Liu K, Li Y, Yu Z
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5788602
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5788602
The Role of Exercise in Reducing Hyperlipidemia-Induced Neuronal Damage in Apolipoprotein E-Deficient Mice.
Bai Y, Feng Y, Jiang B, Yang Y, Pei Z, Yang Q, Cui Y
BioMed research international 2021;2021:5512518
BioMed research international 2021;2021:5512518
The Dietary Supplement γ-Oryzanol Attenuates Hepatic Ischemia Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress and HMGB1/NLRP3 Inflammasome.
Du Y, Zhong F, Cheng H, Li T, Chen Y, Tan P, Huang M, Liang T, Liu Y, Xia X, Fu W
Oxidative medicine and cellular longevity 2021;2021:4628050
Oxidative medicine and cellular longevity 2021;2021:4628050
Destructive Effects of Pyroptosis on Homeostasis of Neuron Survival Associated with the Dysfunctional BBB-Glymphatic System and Amyloid-Beta Accumulation after Cerebral Ischemia/Reperfusion in Rats.
Lyu Z, Chan Y, Li Q, Zhang Q, Liu K, Xiang J, Li X, Cai D, Li Y, Wang B, Yu Z
Neural plasticity 2021;2021:4504363
Neural plasticity 2021;2021:4504363
Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF-κB/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of Preeclampsia.
Zhang Y, Liu W, Zhong Y, Li Q, Wu M, Yang L, Liu X, Zou L
Oxidative medicine and cellular longevity 2021;2021:1806344
Oxidative medicine and cellular longevity 2021;2021:1806344
Rufinamide (RUF) suppresses inflammation and maintains the integrity of the blood-brain barrier during kainic acid-induced brain damage.
Yu H, He B, Han X, Yan T
Open life sciences 2021;16(1):845-855
Open life sciences 2021;16(1):845-855
Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson's Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment.
Que R, Zheng J, Chang Z, Zhang W, Li H, Xie Z, Huang Z, Wang HT, Xu J, Jin D, Yang W, Tan EK, Wang Q
Frontiers in immunology 2021;12:794770
Frontiers in immunology 2021;12:794770
Mesenchymal Stem Cells Alleviate Post-resuscitation Cardiac and Cerebral Injuries by Inhibiting Cell Pyroptosis and Ferroptosis in a Swine Model of Cardiac Arrest.
Xu J, Zhang M, Liu F, Shi L, Jiang X, Chen C, Wang J, Diao M, Khan ZU, Zhang M
Frontiers in pharmacology 2021;12:793829
Frontiers in pharmacology 2021;12:793829
Yi-Zhi-Fang-Dai Formula Exerts Neuroprotective Effects Against Pyroptosis and Blood-Brain Barrier-Glymphatic Dysfunctions to Prevent Amyloid-Beta Acute Accumulation After Cerebral Ischemia and Reperfusion in Rats.
Lyu Z, Li Q, Yu Z, Chan Y, Fu L, Li Y, Zhang C
Frontiers in pharmacology 2021;12:791059
Frontiers in pharmacology 2021;12:791059
Edaravone Plays Protective Effects on LPS-Induced Microglia by Switching M1/M2 Phenotypes and Regulating NLRP3 Inflammasome Activation.
Li J, Dai X, Zhou L, Li X, Pan D
Frontiers in pharmacology 2021;12:691773
Frontiers in pharmacology 2021;12:691773
Inflammasome-Induced Osmotic Pressure and the Mechanical Mechanisms Underlying Astrocytic Swelling and Membrane Blebbing in Pyroptosis.
Zheng Z, Wang T, Chen J, Qiu H, Zhang C, Liu W, Qin S, Tian J, Guo J
Frontiers in immunology 2021;12:688674
Frontiers in immunology 2021;12:688674
Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway.
Liu X, Xu Y, Cheng S, Zhou X, Zhou F, He P, Hu F, Zhang L, Chen Y, Jia Y
Frontiers in pharmacology 2021;12:687394
Frontiers in pharmacology 2021;12:687394
LPS Mediates Bovine Endometrial Epithelial Cell Pyroptosis Directly Through Both NLRP3 Classical and Non-Classical Inflammasome Pathways.
Ma X, Li Y, Shen W, Oladejo AO, Yang J, Jiang W, Imam BH, Wu X, Ding X, Yang Y, Wang S, Yan Z
Frontiers in immunology 2021;12:676088
Frontiers in immunology 2021;12:676088
Sinapic Acid Reduces Oxidative Stress and Pyroptosis via Inhibition of BRD4 in Alcoholic Liver Disease.
Chu J, Yan R, Wang S, Li G, Kang X, Hu Y, Lin M, Shan W, Zhao Y, Wang Z, Sun R, Yao J, Zhang N
Frontiers in pharmacology 2021;12:668708
Frontiers in pharmacology 2021;12:668708
Pin1 Promotes NLRP3 Inflammasome Activation by Phosphorylation of p38 MAPK Pathway in Septic Shock.
Dong R, Xue Z, Fan G, Zhang N, Wang C, Li G, Da Y
Frontiers in immunology 2021;12:620238
Frontiers in immunology 2021;12:620238
H(2)S alleviates aortic aneurysm and dissection: Crosstalk between transforming growth factor 1 signaling and NLRP3 inflammasome.
Cui J, Xu G, Bian F
International journal of cardiology 2021 Sep 1;338:215-225
International journal of cardiology 2021 Sep 1;338:215-225
IF1 inactivation attenuates experimental colitis through downregulation of neutrophil infiltration in colon mucosa.
Zhong G, Zhang J, Guo Y, Wang Y, Wu M, Ren J, Li Y, Zhang X, Zhou B, Zhao W, Lou Y, Wang H, Ye J
International immunopharmacology 2021 Oct;99:107980
International immunopharmacology 2021 Oct;99:107980
Plasma exosomes derived from patients with intestinal Behçet's syndrome induce intestinal epithelial cell pyroptosis.
Hou CC, Ma HF, Ye JF, Luo D, Bao HF, Guan JL
Clinical rheumatology 2021 Oct;40(10):4143-4155
Clinical rheumatology 2021 Oct;40(10):4143-4155
Reactive oxygen species induced by uric acid promote NRK‑52E cell apoptosis through the NEK7‑NLRP3 signaling pathway.
Li D, Wang L, Ou J, Wang C, Zhou J, Lu L, Wu Y, Gao J
Molecular medicine reports 2021 Oct;24(4)
Molecular medicine reports 2021 Oct;24(4)
Ulinastatin protects against sepsis‑induced myocardial injury by inhibiting NLRP3 inflammasome activation.
Qiu J, Xiao X, Gao X, Zhang Y
Molecular medicine reports 2021 Oct;24(4)
Molecular medicine reports 2021 Oct;24(4)
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Zhao Y, Liu X, Zheng Y, Liu W, Ding C
Scientific reports 2021 Oct 18;11(1):20558
Scientific reports 2021 Oct 18;11(1):20558
(-)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD.
Tian X, Xue Y, Xie G, Zhou Y, Xiao H, Ding F, Zhang M
Toxicology and applied pharmacology 2021 Oct 15;429:115674
Toxicology and applied pharmacology 2021 Oct 15;429:115674
Downregulation of phosphoglycerate mutase 5 improves microglial inflammasome activation after traumatic brain injury.
Chen Y, Gong K, Guo L, Zhang B, Chen S, Li Z, Quanhua X, Liu W, Wang Z
Cell death discovery 2021 Oct 12;7(1):290
Cell death discovery 2021 Oct 12;7(1):290
Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.
Hao W, Hao C, Wu C, Xu Y, Wu S, Lu X, Yang J, Jin C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112591
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112591
MCC950 attenuates doxorubicin-induced myocardial injury in vivo and in vitro by inhibiting NLRP3-mediated pyroptosis.
Zhang L, Jiang YH, Fan C, Zhang Q, Jiang YH, Li Y, Xue YT
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Nov;143:112133
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Nov;143:112133
6-Gingerol protects against cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1 / FAF1 complex dissociation-mediated autophagy.
Luo J, Chen J, Yang C, Tan J, Zhao J, Jiang N, Zhao Y
International immunopharmacology 2021 Nov;100:108146
International immunopharmacology 2021 Nov;100:108146
TNFAIP3-upregulated RIP3 exacerbates acute pancreatitis via activating NLRP3 inflammasome.
Wang Y, Song M, Zhou P, Wang J, Zheng J, Xu H
International immunopharmacology 2021 Nov;100:108067
International immunopharmacology 2021 Nov;100:108067
Inhibition of the NLRP3 inflammasome with MCC950 prevents chronic social isolation-induced depression-like behavior in male mice.
Li W, Niu L, Liu Z, Xu X, Shi M, Zhang Y, Deng Y, He J, Xu Y, Wan W, Sun Q, Zhong X, Cao W
Neuroscience letters 2021 Nov 20;765:136290
Neuroscience letters 2021 Nov 20;765:136290
Indole-3-Propionic Acid, a Functional Metabolite of Clostridium sporogenes, Promotes Muscle Tissue Development and Reduces Muscle Cell Inflammation.
Du L, Qi R, Wang J, Liu Z, Wu Z
International journal of molecular sciences 2021 Nov 18;22(22)
International journal of molecular sciences 2021 Nov 18;22(22)
MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs.
Ge S, Yang W, Chen H, Yuan Q, Liu S, Zhao Y, Zhang J
International journal of molecular sciences 2021 Nov 17;22(22)
International journal of molecular sciences 2021 Nov 17;22(22)
Moderate-intensity exercise alleviates pyroptosis by promoting autophagy in osteoarthritis via the P2X7/AMPK/mTOR axis.
Li Z, Huang Z, Zhang H, Lu J, Tian Y, Piao S, Lin Z, Bai L
Cell death discovery 2021 Nov 10;7(1):346
Cell death discovery 2021 Nov 10;7(1):346
Astaxanthin attenuated hyperuricemia and kidney inflammation by inhibiting uric acid synthesis and the NF-κ B/NLRP3 signaling pathways in potassium oxonate and hypoxanthine-induced hyperuricemia mice.
Zhuang J, Zhou X, Liu T, Zhang S, Yuan F, Zhang L, Yang Z, Chen Y
Die Pharmazie 2021 Nov 1;76(11):551-558
Die Pharmazie 2021 Nov 1;76(11):551-558
Paeoniflorin inhibited nod-like receptor protein-3 inflammasome and NF-κB-mediated inflammatory reactions in diabetic foot ulcer by inhibiting the chemokine receptor CXCR2.
Sun X, Wang X, Zhao Z, Chen J, Li C, Zhao G
Drug development research 2021 May;82(3):404-411
Drug development research 2021 May;82(3):404-411
Enterococcus Faecalis activates NLRP3 inflammasomes leading to increased interleukin-1 beta secretion and pyroptosis of THP-1 macrophages.
Ran S, Huang J, Liu B, Gu S, Jiang W, Liang J
Microbial pathogenesis 2021 May;154:104761
Microbial pathogenesis 2021 May;154:104761
17β-Estradiol Reduces Demyelination in Cuprizone-fed Mice by Promoting M2 Microglia Polarity and Regulating NLRP3 Inflammasome.
Aryanpour R, Zibara K, Pasbakhsh P, Jame'ei SB, Namjoo Z, Ghanbari A, Mahmoudi R, Amani S, Kashani IR
Neuroscience 2021 May 21;463:116-127
Neuroscience 2021 May 21;463:116-127
Cordyceps acid alleviates lung cancer in nude mice.
Wang J, Chen H, Li W, Shan L
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
Trueperella pyogenes pyolysin inhibits lipopolysaccharide-induced inflammatory response in endometrium stromal cells via autophagy- and ATF6-dependent mechanism.
Qi M, Liu J, Jiang Q, Niu H, Wang X, Zhou D, Lin P, Chen H, Wang A, Jin Y
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] 2021 Jun;52(2):939-952
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] 2021 Jun;52(2):939-952
Golgi phosphoprotein 3 promotes the proliferation of gallbladder carcinoma cells via regulation of the NLRP3 inflammasome.
Zhu Z, Zhu Q, Cai D, Chen L, Xie W, Bai Y, Luo K
Oncology reports 2021 Jun;45(6)
Oncology reports 2021 Jun;45(6)
Amelioration of Juglanin against LPS-Induced Activation of NLRP3 Inflammasome in Chondrocytes Mediated by SIRT1.
Wang T, Wang J, Sun T, Li Y
Inflammation 2021 Jun;44(3):1119-1129
Inflammation 2021 Jun;44(3):1119-1129
Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo.
Lam HYP, Liang TR, Peng SY
PLoS neglected tropical diseases 2021 Jun;15(6):e0009554
PLoS neglected tropical diseases 2021 Jun;15(6):e0009554
Bone marrow-derived mesenchymal stem cells attenuate silica-induced pulmonary fibrosis by inhibiting apoptosis and pyroptosis but not autophagy in rats.
Zhao Q, Hao C, Wei J, Huang R, Li C, Yao W
Ecotoxicology and environmental safety 2021 Jun 15;216:112181
Ecotoxicology and environmental safety 2021 Jun 15;216:112181
Adiponectin protects obesity-related glomerulopathy by inhibiting ROS/NF-κB/NLRP3 inflammation pathway.
Xu X, Huang X, Zhang L, Huang X, Qin Z, Hua F
BMC nephrology 2021 Jun 10;22(1):218
BMC nephrology 2021 Jun 10;22(1):218
Galectin-9 Targets NLRP3 for Autophagic Degradation to Limit Inflammation.
Wang W, Qin Y, Song H, Wang L, Jia M, Zhao C, Gong M, Zhao W
Journal of immunology (Baltimore, Md. : 1950) 2021 Jun 1;206(11):2692-2699
Journal of immunology (Baltimore, Md. : 1950) 2021 Jun 1;206(11):2692-2699
Macrophage membrane-mediated targeted drug delivery for treatment of spinal cord injury regardless of the macrophage polarization states.
Tang W, Yang Y, Yang L, Tang M, Chen Y, Li C
Asian journal of pharmaceutical sciences 2021 Jul;16(4):459-470
Asian journal of pharmaceutical sciences 2021 Jul;16(4):459-470
Activation of Interleukin-1β Release and Pyroptosis by Transmissible Gastroenteritis Virus Is Dependent on the NOD-Like Receptor Protein 3 Inflammasome in Porcine Intestinal Epithelial Cell Line.
Wei G, Luo S, Wu W, Hu J, Zhou R
Viral immunology 2021 Jul-Aug;34(6):401-409
Viral immunology 2021 Jul-Aug;34(6):401-409
Targeting HDAC6 attenuates nicotine-induced macrophage pyroptosis via NF-κB/NLRP3 pathway.
Xu S, Chen H, Ni H, Dai Q
Atherosclerosis 2021 Jan;317:1-9
Atherosclerosis 2021 Jan;317:1-9
Melatonin ameliorates hepatic steatosis by inhibiting NLRP3 inflammasome in db/db mice.
Yu Y, Chen D, Zhao Y, Zhu J, Dong X
International journal of immunopathology and pharmacology 2021 Jan-Dec;35:20587384211036819
International journal of immunopathology and pharmacology 2021 Jan-Dec;35:20587384211036819
Aberrant spinal mechanical loading stress triggers intervertebral disc degeneration by inducing pyroptosis and nerve ingrowth.
Fu F, Bao R, Yao S, Zhou C, Luo H, Zhang Z, Zhang H, Li Y, Yan S, Yu H, Du W, Yang Y, Jin H, Tong P, Sun ZT, Yue M, Chen D, Wu C, Ruan H
Scientific reports 2021 Jan 12;11(1):772
Scientific reports 2021 Jan 12;11(1):772
The NLRP3 inflammasome drives inflammation in ischemia/reperfusion injury after transient middle cerebral artery occlusion in mice.
Franke M, Bieber M, Kraft P, Weber ANR, Stoll G, Schuhmann MK
Brain, behavior, and immunity 2021 Feb;92:223-233
Brain, behavior, and immunity 2021 Feb;92:223-233
BDNF corrects NLRP3 inflammasome-induced pyroptosis and glucose metabolism reprogramming through KLF2/HK1 pathway in vascular endothelial cells.
Jin H, Zhu Y, Wang XD, Luo EF, Li YP, Wang BL, Chen YF
Cellular signalling 2021 Feb;78:109843
Cellular signalling 2021 Feb;78:109843
Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor α-mediated autophagy.
Meng Q, Li Y, Ji T, Chao Y, Li J, Fu Y, Wang S, Chen Q, Chen W, Huang F, Wang Y, Zhang Q, Wang X, Bian H
Journal of advanced research 2021 Feb;28:149-164
Journal of advanced research 2021 Feb;28:149-164
An In-vivo Study into the Effects of Schisandrin B in the Liver, Spleen, Kidney, and Brain of Acute Thioacetamide-intoxicated Mice.
Lam HYP, Hung MY, Liang TR, Peng SY
Iranian journal of pharmaceutical research : IJPR 2021 Fall;20(4):300-314
Iranian journal of pharmaceutical research : IJPR 2021 Fall;20(4):300-314
Huoxue Qianyang Qutan recipe attenuates cardiac fibrosis by inhibiting the NLRP3 inflammasome signalling pathway in obese hypertensive rats.
Lu B, Xie J, Fu D, Chen X, Zhao M, Gui M, Yao L, Zhou X, Li J
Pharmaceutical biology 2021 Dec;59(1):1045-1057
Pharmaceutical biology 2021 Dec;59(1):1045-1057
Role of miR-145-5p/ CD40 in the inflammation and apoptosis of HUVECs induced by PM(2.5).
Zhang X, Qi W, Shi Y, Li X, Yin J, Huo C, Zhang R, Zhao W, Ye J, Zhou L, Ye L
Toxicology 2021 Dec;464:152993
Toxicology 2021 Dec;464:152993
DDX3X deficiency alleviates LPS-induced H9c2 cardiomyocytes pyroptosis by suppressing activation of NLRP3 inflammasome.
Feng D, Guo L, Liu J, Song Y, Ma X, Hu H, Liu J, Hao E
Experimental and therapeutic medicine 2021 Dec;22(6):1389
Experimental and therapeutic medicine 2021 Dec;22(6):1389
MST4 attenuates NLRP3 inflammasome-mediated neuroinflammation and affects the prognosis after intracerebral hemorrhage in mice.
Wu X, Zhang Y, Zhang Y, Xia L, Yang Y, Wang P, Xu Y, Ren Z, Liu H
Brain research bulletin 2021 Dec;177:31-38
Brain research bulletin 2021 Dec;177:31-38
ESR2 regulates PINK1-mediated mitophagy via transcriptional repression of microRNA-423 expression to promote asthma development.
Kong X, Chen R, Zhang L, Wu M, Wu J, Wei Y, Dai W, Jiang Y
Pharmacological research 2021 Dec;174:105956
Pharmacological research 2021 Dec;174:105956
Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia.
Li M, Lu H, Wang X, Duan C, Zhu X, Zhang Y, Ge X, Ji F, Wang X, Su J, Zhang D
Molecular immunology 2021 Dec;140:250-266
Molecular immunology 2021 Dec;140:250-266
Sub-chronic exposure to realgar induces liver injury via upregulating the TXNIP/NLRP3 pathway and disturbing bile acid homeostasis in mice.
Li A, Wu X, Yang J, Li J, Guo H, Zhang Y, Jiang H, Huo T
Journal of ethnopharmacology 2021 Dec 5;281:114584
Journal of ethnopharmacology 2021 Dec 5;281:114584
Exposure to DEHP induces testis toxicity and injury through the ROS/mTOR/NLRP3 signaling pathway in immature rats.
Hong Y, Zhou Y, Shen L, Wei Y, Long C, Fu Y, Wu H, Wang J, Wu Y, Wu S, Wei G
Ecotoxicology and environmental safety 2021 Dec 20;227:112889
Ecotoxicology and environmental safety 2021 Dec 20;227:112889
Prototheca spp. induce an inflammatory response via mtROS-mediated activation of NF-κB and NLRP3 inflammasome pathways in bovine mammary epithelial cell cultures.
Zhao W, He F, Barkema HW, Xu S, Gao J, Liu G, Deng Z, Shahid M, Shi Y, Kastelic JP, Han B
Veterinary research 2021 Dec 11;52(1):144
Veterinary research 2021 Dec 11;52(1):144
FNDC5 induces M2 macrophage polarization and promotes hepatocellular carcinoma cell growth by affecting the PPARγ/NF-κB/NLRP3 pathway.
Liu H, Wang M, Jin Z, Sun D, Zhu T, Liu X, Tan X, Shi G
Biochemical and biophysical research communications 2021 Dec 10;582:77-85
Biochemical and biophysical research communications 2021 Dec 10;582:77-85
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.
Ma L, Li C, Lian S, Xu B, Lv H, Liu Y, Lu J, Ji H, Li S, Guo J, Yang H
Journal of cellular and molecular medicine 2021 Aug;25(16):8015-8027
Journal of cellular and molecular medicine 2021 Aug;25(16):8015-8027
Emodin ameliorates acute pancreatitis-induced lung injury by suppressing NLRP3 inflammasome-mediated neutrophil recruitment.
Jiang N, Li Z, Luo Y, Jiang L, Zhang G, Yang Q, Chen H
Experimental and therapeutic medicine 2021 Aug;22(2):857
Experimental and therapeutic medicine 2021 Aug;22(2):857
TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation.
Qin Y, Li Q, Liang W, Yan R, Tong L, Jia M, Zhao C, Zhao W
Nature communications 2021 Aug 9;12(1):4794
Nature communications 2021 Aug 9;12(1):4794
Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.
Ji Q, Wang L, Liu J, Wu Y, Lv H, Wen Y, Shi L, Qu B, Szentmáry N
Inflammation 2021 Apr;44(2):682-692
Inflammation 2021 Apr;44(2):682-692
Low NLRP3 expression predicts a better prognosis of colorectal cancer.
Shi F, Wei B, Lan T, Xiao Y, Quan X, Chen J, Zhao C, Gao J
Bioscience reports 2021 Apr 30;41(4)
Bioscience reports 2021 Apr 30;41(4)
Salidroside alleviates diabetic neuropathic pain through regulation of the AMPK-NLRP3 inflammasome axis.
Zheng T, Wang Q, Bian F, Zhao Y, Ma W, Zhang Y, Lu W, Lei P, Zhang L, Hao X, Chen L
Toxicology and applied pharmacology 2021 Apr 1;416:115468
Toxicology and applied pharmacology 2021 Apr 1;416:115468
Protective Role of Coenzyme Q10 in Acute Sepsis-Induced Liver Injury in BALB/c Mice.
Li QW, Yang Q, Liu HY, Wu YL, Hao YH, Zhang XQ
BioMed research international 2020;2020:7598375
BioMed research international 2020;2020:7598375
ATP-Sensitive Potassium Channels Mediate the Cardioprotective Effect of Panax notoginseng Saponins against Myocardial Ischaemia-Reperfusion Injury and Inflammatory Reaction.
Ning K, Jiang L, Hu T, Wang X, Liu A, Bao Y
BioMed research international 2020;2020:3039184
BioMed research international 2020;2020:3039184
Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BALB/c Mice.
Guo LP, Liu SX, Yang Q, Liu HY, Xu LL, Hao YH, Zhang XQ
BioMed research international 2020;2020:1594726
BioMed research international 2020;2020:1594726
Maresin 1 Attenuates Radicular Pain Through the Inhibition of NLRP3 Inflammasome-Induced Pyroptosis via NF-κB Signaling.
Wang YH, Li Y, Wang JN, Zhao QX, Jin J, Wen S, Wang SC, Sun T
Frontiers in neuroscience 2020;14:831
Frontiers in neuroscience 2020;14:831
Resatorvid Relieves Breast Cancer Complicated with Depression by Inactivating Hippocampal Microglia Through TLR4/NF-κB/NLRP3 Signaling Pathway.
Luo W, Han Y, Meng P, Yang Q, Zhao H, Ling J, Wang Y
Cancer management and research 2020;12:13003-13014
Cancer management and research 2020;12:13003-13014
Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects via the TXNIP-NLRP3-GSDMD Axis.
Li N, Zhao T, Cao Y, Zhang H, Peng L, Wang Y, Zhou X, Wang Q, Li J, Yan M, Dong X, Zhao H, Li P
Frontiers in pharmacology 2020;11:623489
Frontiers in pharmacology 2020;11:623489
Resolvin D1 ameliorates Inflammation-Mediated Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in rats by Modulating A20 and NLRP3 Inflammasome.
Wei C, Guo S, Liu W, Jin F, Wei B, Fan H, Su H, Liu J, Zhang N, Fang D, Li G, Shu S, Li X, He X, Zhang X, Duan C
Frontiers in pharmacology 2020;11:610734
Frontiers in pharmacology 2020;11:610734
Cardamonin Reduces Acetaminophen-Induced Acute Liver Injury in Mice via Activating Autophagy and NFE2L2 Signaling.
Xu Q, Fan Y, Loor JJ, Liang Y, Sun X, Jia H, Zhao C, Xu C
Frontiers in pharmacology 2020;11:601716
Frontiers in pharmacology 2020;11:601716
Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4.
Ding PH, Yang MX, Wang NN, Jin LJ, Dong Y, Cai X, Chen LL
Frontiers in microbiology 2020;11:1881
Frontiers in microbiology 2020;11:1881
CoenzymeQ10-Induced Activation of AMPK-YAP-OPA1 Pathway Alleviates Atherosclerosis by Improving Mitochondrial Function, Inhibiting Oxidative Stress and Promoting Energy Metabolism.
Xie T, Wang C, Jin Y, Meng Q, Liu Q, Wu J, Sun H
Frontiers in pharmacology 2020;11:1034
Frontiers in pharmacology 2020;11:1034
Carvacrol may alleviate vascular inflammation in diabetic db/db mice.
Zhao W, Deng C, Han Q, Xu H, Chen Y
International journal of molecular medicine 2020 Sep;46(3):977-988
International journal of molecular medicine 2020 Sep;46(3):977-988
Humanin Ameliorates Free Fatty Acid-Induced Endothelial Inflammation by Suppressing the NLRP3 Inflammasome.
Li W, Zhang D, Yuan W, Wang C, Huang Q, Luo J
ACS omega 2020 Sep 8;5(35):22039-22045
ACS omega 2020 Sep 8;5(35):22039-22045
Antimicrobial Effect of Zophobas morio Hemolymph against Bovine Mastitis Pathogens.
Du M, Liu X, Xu J, Li S, Wang S, Zhu Y, Wang J
Microorganisms 2020 Sep 28;8(10)
Microorganisms 2020 Sep 28;8(10)
Inflammasome/NF-κB translocation inhibition via PPARγ agonist mitigates inorganic mercury induced nephrotoxicity.
Li S, Shi M, Wan Y, Wang Y, Zhu M, Wang B, Zhan Y, Ran B, Wu C
Ecotoxicology and environmental safety 2020 Sep 15;201:110801
Ecotoxicology and environmental safety 2020 Sep 15;201:110801
Puerarin ameliorates retinal ganglion cell damage induced by retinal ischemia/reperfusion through inhibiting the activation of TLR4/NLRP3 inflammasome.
Guan L, Li C, Zhang Y, Gong J, Wang G, Tian P, Shen N
Life sciences 2020 Sep 1;256:117935
Life sciences 2020 Sep 1;256:117935
Mesenchymal stem cells-derived exosomes ameliorate intervertebral disc degeneration through inhibiting pyroptosis.
Zhang J, Zhang J, Zhang Y, Liu W, Ni W, Huang X, Yuan J, Zhao B, Xiao H, Xue F
Journal of cellular and molecular medicine 2020 Oct;24(20):11742-11754
Journal of cellular and molecular medicine 2020 Oct;24(20):11742-11754
Peptidome analysis of cerebrospinal fluid in neonates with hypoxic-ischemic brain damage.
Hou X, Yuan Z, Wang X, Cheng R, Zhou X, Qiu J
Molecular brain 2020 Oct 2;13(1):133
Molecular brain 2020 Oct 2;13(1):133
LncRNA GAS5 inhibits NLRP3 inflammasome activation-mediated pyroptosis in diabetic cardiomyopathy by targeting miR-34b-3p/AHR.
Xu Y, Fang H, Xu Q, Xu C, Yang L, Huang C
Cell cycle (Georgetown, Tex.) 2020 Nov;19(22):3054-3065
Cell cycle (Georgetown, Tex.) 2020 Nov;19(22):3054-3065
UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression.
Song H, Zhao C, Yu Z, Li Q, Yan R, Qin Y, Jia M, Zhao W
Nature communications 2020 Nov 27;11(1):6042
Nature communications 2020 Nov 27;11(1):6042
Self-recovery study of the adverse effects of fluoride on small intestine: Involvement of pyroptosis induced inflammation.
Li M, Wang J, Wu P, Manthari RK, Zhao Y, Li W, Wang J
The Science of the total environment 2020 Nov 10;742:140533
The Science of the total environment 2020 Nov 10;742:140533
Oroxylin A inhibits carcinogen-induced skin tumorigenesis through inhibition of inflammation by regulating SHCBP1 in mice.
Huang H, Cai H, Zhang L, Hua Z, Shi J, Wei Y
International immunopharmacology 2020 Mar;80:106123
International immunopharmacology 2020 Mar;80:106123
Peritoneal M2 macrophage transplantation as a potential cell therapy for enhancing renal repair in acute kidney injury.
Mao R, Wang C, Zhang F, Zhao M, Liu S, Liao G, Li L, Chen Y, Cheng J, Liu J, Lu Y
Journal of cellular and molecular medicine 2020 Mar;24(6):3314-3327
Journal of cellular and molecular medicine 2020 Mar;24(6):3314-3327
Resveratrol protects against CIH-induced myocardial injury by targeting Nrf2 and blocking NLRP3 inflammasome activation.
Sun ZM, Guan P, Luo LF, Qin LY, Wang N, Zhao YS, Ji ES
Life sciences 2020 Mar 15;245:117362
Life sciences 2020 Mar 15;245:117362
TNF-α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury.
Wang Y, Zhang H, Chen Q, Jiao F, Shi C, Pei M, Lv J, Zhang H, Wang L, Gong Z
Cell proliferation 2020 Jun;53(6):e12829
Cell proliferation 2020 Jun;53(6):e12829
Laquinimod inhibits MMP+ induced NLRP3 inflammasome activation in human neuronal cells.
Zhang X, Jin J, Xie A
Immunopharmacology and immunotoxicology 2020 Jun;42(3):264-271
Immunopharmacology and immunotoxicology 2020 Jun;42(3):264-271
Geniposide inhibits NLRP3 inflammasome activation via autophagy in BV-2 microglial cells exposed to oxygen-glucose deprivation/reoxygenation.
Fu C, Zhang X, Lu Y, Wang F, Xu Z, Liu S, Zheng H, Liu X
International immunopharmacology 2020 Jul;84:106547
International immunopharmacology 2020 Jul;84:106547
Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1/Parkin signaling pathway.
Gao Y, Li J, Li J, Hu C, Zhang L, Yan J, Li L, Zhang L
Biochemical pharmacology 2020 Jul;177:113997
Biochemical pharmacology 2020 Jul;177:113997
RDP3, A Novel Antigout Peptide Derived from Water Extract of Rice.
Liu N, Wang Y, Zeng L, Yin S, Hu Y, Li S, Fu Y, Zhang X, Xie C, Shu L, Li Y, Sun H, Yang M, Sun J, Yang X
Journal of agricultural and food chemistry 2020 Jul 8;68(27):7143-7151
Journal of agricultural and food chemistry 2020 Jul 8;68(27):7143-7151
Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264.7 cells: The role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK.
Xie C, Ge M, Jin J, Xu H, Mao L, Geng S, Wu J, Zhu J, Li X, Zhong C
Journal of hazardous materials 2020 Jul 15;394:122549
Journal of hazardous materials 2020 Jul 15;394:122549
Hyperglycemia suppresses the regulatory effect of hypoxia-inducible factor-1α in pulmonary Aspergillus fumigatus infection.
Ye Y, Chen Y, Sun J, Zhang H, Meng Y, Li W, Wang W
Pathogens and disease 2020 Jul 1;78(5)
Pathogens and disease 2020 Jul 1;78(5)
Discovery of novel TNNI3K inhibitor suppresses pyroptosis and apoptosis in murine myocardial infarction injury.
Pang H, Wang N, Chai J, Wang X, Zhang Y, Bi Z, Wu W, He G
European journal of medicinal chemistry 2020 Jul 1;197:112314
European journal of medicinal chemistry 2020 Jul 1;197:112314
Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome and uric acid reabsorption.
Cui D, Liu S, Tang M, Lu Y, Zhao M, Mao R, Wang C, Yuan Y, Li L, Chen Y, Cheng J, Lu Y, Liu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Jan;66:153111
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Jan;66:153111
Silibinin inhibits migration and invasion of breast cancer MDA-MB-231 cells through induction of mitochondrial fusion.
Si L, Fu J, Liu W, Hayashi T, Nie Y, Mizuno K, Hattori S, Fujisaki H, Onodera S, Ikejima T
Molecular and cellular biochemistry 2020 Jan;463(1-2):189-201
Molecular and cellular biochemistry 2020 Jan;463(1-2):189-201
Lactobacillus johnsonii L531 ameliorates enteritis via elimination of damaged mitochondria and suppression of SQSTM1-dependent mitophagy in a Salmonella infantis model of piglet diarrhea.
Xia B, Yu J, He T, Liu X, Su J, Wang M, Wang J, Zhu Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2821-2839
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2821-2839
Inhibition of the SIRT1 signaling pathway exacerbates endoplasmic reticulum stress induced by renal ischemia/reperfusion injury in type 1 diabetic rats.
Zhang J, Wang L, Gong D, Yang Y, Liu X, Chen Z
Molecular medicine reports 2020 Feb;21(2):695-704
Molecular medicine reports 2020 Feb;21(2):695-704
α-synuclein promotes progression of Parkinson's disease by upregulating autophagy signaling pathway to activate NLRP3 inflammasome.
Wang X, Chi J, Huang D, Ding L, Zhao X, Jiang L, Yu Y, Gao F
Experimental and therapeutic medicine 2020 Feb;19(2):931-938
Experimental and therapeutic medicine 2020 Feb;19(2):931-938
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.
Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, Chan ER, Wang Q, Xu R, Flanagan ME, Pieper AA, Qi X
Science advances 2020 Dec;6(49)
Science advances 2020 Dec;6(49)
The protective effects of phoenixin-14 against lipopolysaccharide-induced inflammation and inflammasome activation in astrocytes.
Wang J, Zheng B, Yang S, Tang X, Wang J, Wei D
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2020 Aug;69(8):779-787
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2020 Aug;69(8):779-787
A Novel Mechanism of Specialized Proresolving Lipid Mediators Mitigating Radicular Pain: The Negative Interaction with NLRP3 Inflammasome.
Wang YH, Li Y, Wang JN, Zhao QX, Wen S, Wang SC, Sun T
Neurochemical research 2020 Aug;45(8):1860-1869
Neurochemical research 2020 Aug;45(8):1860-1869
Lactobacillus johnsonii L531 Ameliorates Escherichia coli-Induced Cell Damage via Inhibiting NLRP3 Inflammasome Activity and Promoting ATG5/ATG16L1-Mediated Autophagy in Porcine Mammary Epithelial Cells.
Zou YJ, Xu JJ, Wang X, Zhu YH, Wu Q, Wang JF
Veterinary sciences 2020 Aug 14;7(3)
Veterinary sciences 2020 Aug 14;7(3)
Inhibiting pannexin-1 alleviates sepsis-induced acute kidney injury via decreasing NLRP3 inflammasome activation and cell apoptosis.
Huang G, Bao J, Shao X, Zhou W, Wu B, Ni Z, Wang L
Life sciences 2020 Aug 1;254:117791
Life sciences 2020 Aug 1;254:117791
Saikosaponin-d ameliorates dextran sulfate sodium-induced colitis by suppressing NF-κB activation and modulating the gut microbiota in mice.
Li P, Wu M, Xiong W, Li J, An Y, Ren J, Xie Y, Xue H, Yan D, Li M, Zhong G
International immunopharmacology 2020 Apr;81:106288
International immunopharmacology 2020 Apr;81:106288
Salidroside Decreases Atherosclerosis Plaque Formation via Inhibiting Endothelial Cell Pyroptosis.
Xing SS, Yang J, Li WJ, Li J, Chen L, Yang YT, Lei X, Li J, Wang K, Liu X
Inflammation 2020 Apr;43(2):433-440
Inflammation 2020 Apr;43(2):433-440
IFN Regulatory Factor 1 Mediates Macrophage Pyroptosis Induced by Oxidized Low-Density Lipoprotein in Patients with Acute Coronary Syndrome.
Guo M, Yan R, Yao H, Duan L, Sun M, Xue Z, Jia Y
Mediators of inflammation 2019;2019:2917128
Mediators of inflammation 2019;2019:2917128
NLRP3 inflammasome activation by estrogen promotes the progression of human endometrial cancer.
Liu SG, Wu XX, Hua T, Xin XY, Feng DL, Chi SQ, Wang XX, Wang HB
OncoTargets and therapy 2019;12:6927-6936
OncoTargets and therapy 2019;12:6927-6936
Detection of Exosomal PD-L1 RNA in Saliva of Patients With Periodontitis.
Yu J, Lin Y, Xiong X, Li K, Yao Z, Dong H, Jiang Z, Yu D, Yeung SJ, Zhang H
Frontiers in genetics 2019;10:202
Frontiers in genetics 2019;10:202
NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis.
Ershaid N, Sharon Y, Doron H, Raz Y, Shani O, Cohen N, Monteran L, Leider-Trejo L, Ben-Shmuel A, Yassin M, Gerlic M, Ben-Baruch A, Pasmanik-Chor M, Apte R, Erez N
Nature communications 2019 Sep 26;10(1):4375
Nature communications 2019 Sep 26;10(1):4375
Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation.
Jia C, Zhang J, Chen H, Zhuge Y, Chen H, Qian F, Zhou K, Niu C, Wang F, Qiu H, Wang Z, Xiao J, Rong X, Chu M
Cell death & disease 2019 Oct 14;10(10):778
Cell death & disease 2019 Oct 14;10(10):778
Iguratimod (T-614) attenuates severe acute pancreatitis by inhibiting the NLRP3 inflammasome and NF-κB pathway.
Hou C, Zhu X, Shi C, Peng Y, Huang D, Li Q, Miao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Nov;119:109455
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Nov;119:109455
Glycyrrhizin attenuates hepatic ischemia-reperfusion injury by suppressing HMGB1-dependent GSDMD-mediated kupffer cells pyroptosis.
Hua S, Ma M, Fei X, Zhang Y, Gong F, Fang M
International immunopharmacology 2019 Mar;68:145-155
International immunopharmacology 2019 Mar;68:145-155
Conjugated Linoleic Acid Ameliorates High Fructose-Induced Hyperuricemia and Renal Inflammation in Rats via NLRP3 Inflammasome and TLR4 Signaling Pathway.
Tan J, Wan L, Chen X, Li X, Hao X, Li X, Li J, Ding H
Molecular nutrition & food research 2019 Jun;63(12):e1801402
Molecular nutrition & food research 2019 Jun;63(12):e1801402
MicroRNA-135b alleviates MPP(+)-mediated Parkinson's disease in in vitro model through suppressing FoxO1-induced NLRP3 inflammasome and pyroptosis.
Zeng R, Luo DX, Li HP, Zhang QS, Lei SS, Chen JH
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2019 Jul;65:125-133
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2019 Jul;65:125-133
Enterococcus faecalis induces apoptosis and pyroptosis of human osteoblastic MG63 cells via the NLRP3 inflammasome.
Ran S, Chu M, Gu S, Wang J, Liang J
International endodontic journal 2019 Jan;52(1):44-53
International endodontic journal 2019 Jan;52(1):44-53
Involvement of NLRP3 inflammasome in methamphetamine-induced microglial activation through miR-143/PUMA axis.
Du L, Shen K, Bai Y, Chao J, Hu G, Zhang Y, Yao H
Toxicology letters 2019 Feb;301:53-63
Toxicology letters 2019 Feb;301:53-63
LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma.
Wang K, Xu T, Ruan H, Xiao H, Liu J, Song Z, Cao Q, Bao L, Liu D, Wang C, Cheng G, Liang H, Chen Z, Yang H, Chen K, Zhang X
Cell death & disease 2019 Feb 15;10(3):159
Cell death & disease 2019 Feb 15;10(3):159
Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota.
Wu M, Li P, An Y, Ren J, Yan D, Cui J, Li D, Li M, Wang M, Zhong G
Pharmacological research 2019 Dec;150:104489
Pharmacological research 2019 Dec;150:104489
Sal B Alleviates Myocardial Ischemic Injury by Inhibiting TLR4 and the Priming Phase of NLRP3 Inflammasome.
Hu Y, Li Q, Pan Y, Xu L
Molecules (Basel, Switzerland) 2019 Dec 3;24(23)
Molecules (Basel, Switzerland) 2019 Dec 3;24(23)
Protective effects of microRNA-22-3p against retinal pigment epithelial inflammatory damage by targeting NLRP3 inflammasome.
Hu Z, Lv X, Chen L, Gu X, Qian H, Fransisca S, Zhang Z, Liu Q, Xie P
Journal of cellular physiology 2019 Aug;234(10):18849-18857
Journal of cellular physiology 2019 Aug;234(10):18849-18857
Role of Thymoquinone in Cardiac Damage Caused by Sepsis from BALB/c Mice.
Liu H, Sun Y, Zhang Y, Yang G, Guo L, Zhao Y, Pei Z
Inflammation 2019 Apr;42(2):516-525
Inflammation 2019 Apr;42(2):516-525
NLRP3/IL1β inflammasome associated with the aging bladder triggers bladder dysfunction in female rats.
Chen L, He PL, Yang J, Yang YF, Wang K, Amend B, Stenzl A, Zhang YM, Wang ZL, Xing SS, Luo X
Molecular medicine reports 2019 Apr;19(4):2960-2968
Molecular medicine reports 2019 Apr;19(4):2960-2968
Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Activation of NLRP3 and NLRC4 Inflammasomes With Differential Requirement for ASC.
Wu Q, Zhu YH, Xu J, Liu X, Duan C, Wang MJ, Wang JF
Frontiers in microbiology 2018;9:1661
Frontiers in microbiology 2018;9:1661
Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis.
Guo Q, Wu Y, Hou Y, Liu Y, Liu T, Zhang H, Fan C, Guan H, Li Y, Shan Z, Teng W
Frontiers in immunology 2018;9:1197
Frontiers in immunology 2018;9:1197
Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway.
Zheng T, Yang X, Li W, Wang Q, Chen L, Wu D, Bian F, Xing S, Jin S
Oxidative medicine and cellular longevity 2018;2018:8597897
Oxidative medicine and cellular longevity 2018;2018:8597897
Tumour YAP1 and PTEN expression correlates with tumour-associated myeloid suppressor cell expansion and reduced survival in colorectal cancer.
Yang R, Cai TT, Wu XJ, Liu YN, He J, Zhang XS, Ma G, Li J
Immunology 2018 Oct;155(2):263-272
Immunology 2018 Oct;155(2):263-272
Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response.
Bando H, Lee Y, Sakaguchi N, Pradipta A, Ma JS, Tanaka S, Cai Y, Liu J, Shen J, Nishikawa Y, Sasai M, Yamamoto M
mBio 2018 Oct 9;9(5)
mBio 2018 Oct 9;9(5)
MCMV triggers ROS/NLRP3-associated inflammasome activation in the inner ear of mice and cultured spiral ganglion neurons, contributing to sensorineural hearing loss.
Zhuang W, Wang C, Shi X, Qiu S, Zhang S, Xu B, Chen M, Jiang W, Dong H, Qiao Y
International journal of molecular medicine 2018 Jun;41(6):3448-3456
International journal of molecular medicine 2018 Jun;41(6):3448-3456
Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts.
Stødle GS, Silva GB, Tangerås LH, Gierman LM, Nervik I, Dahlberg UE, Sun C, Aune MH, Thomsen LCV, Bjørge L, Iversen AC
Clinical and experimental immunology 2018 Jul;193(1):84-94
Clinical and experimental immunology 2018 Jul;193(1):84-94
Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis.
Wu X, Zhang H, Qi W, Zhang Y, Li J, Li Z, Lin Y, Bai X, Liu X, Chen X, Yang H, Xu C, Zhang Y, Yang B
Cell death & disease 2018 Feb 7;9(2):171
Cell death & disease 2018 Feb 7;9(2):171
Salvianolate reduces atrial fibrillation through suppressing atrial interstitial fibrosis by inhibiting TGF-β1/Smad2/3 and TXNIP/NLRP3 inflammasome signaling pathways in post-MI rats.
Qiu H, Liu W, Lan T, Pan W, Chen X, Wu H, Xu D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 Dec 1;51:255-265
Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 Dec 1;51:255-265
Anti-inflammatory capacity of Lactobacillus rhamnosus GG in monophasic variant Salmonella infected piglets is correlated with impeding NLRP6-mediated host inflammatory responses.
Yu J, Zhu YH, Yang GY, Zhang W, Zhou D, Su JH, Wang JF
Veterinary microbiology 2017 Oct;210:91-100
Veterinary microbiology 2017 Oct;210:91-100
Analysis of the expression of NLRP3 and AIM2 in periapical lesions with apical periodontitis and microbial analysis outside the apical segment of teeth.
Ran S, Liu B, Gu S, Sun Z, Liang J
Archives of oral biology 2017 Jun;78:39-47
Archives of oral biology 2017 Jun;78:39-47
Protection of Mcc950 against high-glucose-induced human retinal endothelial cell dysfunction.
Zhang Y, Lv X, Hu Z, Ye X, Zheng X, Ding Y, Xie P, Liu Q
Cell death & disease 2017 Jul 20;8(7):e2941
Cell death & disease 2017 Jul 20;8(7):e2941
Comparative effects of schisandrin A, B, and C on Propionibacterium acnes-induced, NLRP3 inflammasome activation-mediated IL-1β secretion and pyroptosis.
Guo M, An F, Yu H, Wei X, Hong M, Lu Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Dec;96:129-136
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Dec;96:129-136
Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.
Gao Z, Han Y, Hu Y, Wu X, Wang Y, Zhang X, Fu J, Zou X, Zhang J, Chen X, Jose PA, Lu X, Zeng C
PloS one 2016;11(2):e0149032
PloS one 2016;11(2):e0149032
NLRP3 inflammasome mediates contrast media-induced acute kidney injury by regulating cell apoptosis.
Shen J, Wang L, Jiang N, Mou S, Zhang M, Gu L, Shao X, Wang Q, Qi C, Li S, Wang W, Che X, Ni Z
Scientific reports 2016 Oct 10;6:34682
Scientific reports 2016 Oct 10;6:34682
New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.
Ding C, Zhao Y, Shi X, Zhang N, Zu G, Li Z, Zhou J, Gao D, Lv L, Tian X, Yao J
Scientific reports 2016 Jun 27;6:28734
Scientific reports 2016 Jun 27;6:28734
Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Inflammation and Cell Damage via Attenuation of ASC-Independent NLRP3 Inflammasome Activation.
Wu Q, Liu MC, Yang J, Wang JF, Zhu YH
Applied and environmental microbiology 2016 Feb 15;82(4):1173-1182
Applied and environmental microbiology 2016 Feb 15;82(4):1173-1182
PEDF Inhibits the Activation of NLRP3 Inflammasome in Hypoxia Cardiomyocytes through PEDF Receptor/Phospholipase A2.
Zhou Z, Wang Z, Guan Q, Qiu F, Li Y, Liu Z, Zhang H, Dong H, Zhang Z
International journal of molecular sciences 2016 Dec 12;17(12)
International journal of molecular sciences 2016 Dec 12;17(12)
Increased expression of NLRP3 inflammasome components and interleukin-18 in patients with bullous pemphigoid.
Fang H, Shao S, Cao T, Lei J, Dang E, Zhang J, Wang G
Journal of dermatological science 2016 Aug;83(2):116-23
Journal of dermatological science 2016 Aug;83(2):116-23
P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation.
Peng K, Liu L, Wei D, Lv Y, Wang G, Xiong W, Wang X, Altaf A, Wang L, He D, Wang H, Qu P
International journal of molecular medicine 2015 May;35(5):1179-88
International journal of molecular medicine 2015 May;35(5):1179-88
Protection of seven dibenzocyclooctadiene lignans from Schisandra chinensis against serum and glucose deprivation injury in SH-SY5Y cells.
E Q, Tang M, Zhang X, Shi Y, Wang D, Gu Y, Li S, Liang X, Wang Z, Wang C
Cell biology international 2015 Dec;39(12):1418-24
Cell biology international 2015 Dec;39(12):1418-24
Thioredoxin-interacting protein mediates NALP3 inflammasome activation in podocytes during diabetic nephropathy.
Gao P, Meng XF, Su H, He FF, Chen S, Tang H, Tian XJ, Fan D, Wang YM, Liu JS, Zhu ZH, Zhang C
Biochimica et biophysica acta 2014 Nov;1843(11):2448-60
Biochimica et biophysica acta 2014 Nov;1843(11):2448-60
Mulberroside A protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion.
Wang CP, Zhang LZ, Li GC, Shi YW, Li JL, Zhang XC, Wang ZW, Ding F, Liang XM
Journal of neuroscience research 2014 Jul;92(7):944-54
Journal of neuroscience research 2014 Jul;92(7):944-54
NLRP3 deficiency ameliorates neurovascular damage in experimental ischemic stroke.
Yang F, Wang Z, Wei X, Han H, Meng X, Zhang Y, Shi W, Li F, Xin T, Pang Q, Yi F
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2014 Apr;34(4):660-7
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2014 Apr;34(4):660-7
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 19771-1-AP(NALP3 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using NLRP3 antibody 19771-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human bladder using 19771-1-AP(NALP3 antibody) at dilution of 1:200 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human bladder using 19771-1-AP(NALP3 antibody) at dilution of 1:200 (under 40x lens)
- Sample type
- tissue
