10-3018-25
antibody from ABEOMICS Inc.
Targeting: NLRP3
AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, DFNA34, FCAS, FCU, MWS, NALP3, PYPAF1
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 10-3018-25 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-NALP3 Antibody
- Antibody type
- Monoclonal
- Description
- NALP3 (NACHT, LRR and PYD domains-containing protein 3), otherwise known as cryopyrin, is a member of the NLR (Nod-like-receptors) family. This is a pyrin-like protein, having N-terminal CARD or pyrin domains needed for homotypic protein protein interaction, an intermediate nucleotide binding self oligomerization NACHT domain and a C-terminal domain containing leucine rich repeats (LRRs). NALP3 is a key component of innate immunity and its expression is restricted to immune cells and chondrocytes. It interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kB signaling, and it plays an important role in the regulation of inflammation, the immune response, and apoptosis.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
A partial length recombinant NALP3
protein (amino acids 150-385) was u
sed as the immunogen for this antib
ody.- Isotype
- IgG
- Antibody clone number
- ABM2D48
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
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Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Western blot analysis of NALP3. Anti- NALP3 antibody (Clone: ABM2D48) was tested at 8 µg/ml on NIH 3T3 lysate.
- Protocol
- Protocol
Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Immunohistochemical analysis of NALP3 in human spleen tissue using NALP3 antibody (Clone: ABM2D48) at 5 µg/ml.
- Protocol
- Protocol