ALX-804-819-C100
antibody from Enzo Life Sciences
Targeting: NLRP3
AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, DFNA34, FCAS, FCU, MWS, NALP3, PYPAF1
Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Immunocytochemistry [1]
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- Product number
- ALX-804-819-C100 - Provider product page
- Provider
- Enzo Life Sciences
- Proper citation
- Enzo Life Sciences Cat#ALX-804-819-C100, RRID:AB_2051972
- Product name
- NLRP3/NALP3 (human) monoclonal antibody (Nalpy3-b)
- Antibody type
- Monoclonal
- Antigen
- Recombinant protein fragment
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- Nalpy3-b
- Vial size
- 100 μg
- Storage
- -20°C
- Handling
- Avoid freeze/thaw cycles.
Submitted references Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease.
Dysregulated production of interleukin-1β upon activation of the NLRP3 inflammasome in patients with familial Mediterranean fever.
Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells.
NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration.
Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells.
Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome.
Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases.
Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response.
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.
Zhou Q, Wang H, Schwartz DM, Stoffels M, Park YH, Zhang Y, Yang D, Demirkaya E, Takeuchi M, Tsai WL, Lyons JJ, Yu X, Ouyang C, Chen C, Chin DT, Zaal K, Chandrasekharappa SC, Hanson EP, Yu Z, Mullikin JC, Hasni SA, Wertz IE, Ombrello AK, Stone DL, Hoffmann P, Jones A, Barham BK, Leavis HL, van Royen-Kerkof A, Sibley C, Batu ED, Gül A, Siegel RM, Boehm M, Milner JD, Ozen S, Gadina M, Chae J, Laxer RM, Kastner DL, Aksentijevich I
Nature genetics 2016 Jan;48(1):67-73
Nature genetics 2016 Jan;48(1):67-73
Dysregulated production of interleukin-1β upon activation of the NLRP3 inflammasome in patients with familial Mediterranean fever.
Repa A, Bertsias GK, Petraki E, Choulaki C, Vassou D, Kambas K, Boumpas DT, Goulielmos G, Sidiropoulos P
Human immunology 2015 Jul;76(7):488-95
Human immunology 2015 Jul;76(7):488-95
Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells.
McGilligan VE, Gregory-Ksander MS, Li D, Moore JE, Hodges RR, Gilmore MS, Moore TC, Dartt DA
PloS one 2013;8(9):e74010
PloS one 2013;8(9):e74010
NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration.
Tseng WA, Thein T, Kinnunen K, Lashkari K, Gregory MS, D'Amore PA, Ksander BR
Investigative ophthalmology & visual science 2013 Jan 7;54(1):110-20
Investigative ophthalmology & visual science 2013 Jan 7;54(1):110-20
Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells.
Benoit ME, Clarke EV, Morgado P, Fraser DA, Tenner AJ
Journal of immunology (Baltimore, Md. : 1950) 2012 Jun 1;188(11):5682-93
Journal of immunology (Baltimore, Md. : 1950) 2012 Jun 1;188(11):5682-93
Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome.
Lev-Sagie A, Prus D, Linhares IM, Lavy Y, Ledger WJ, Witkin SS
American journal of obstetrics and gynecology 2009 Mar;200(3):303.e1-6
American journal of obstetrics and gynecology 2009 Mar;200(3):303.e1-6
Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases.
Shio MT, Eisenbarth SC, Savaria M, Vinet AF, Bellemare MJ, Harder KW, Sutterwala FS, Bohle DS, Descoteaux A, Flavell RA, Olivier M
PLoS pathogens 2009 Aug;5(8):e1000559
PLoS pathogens 2009 Aug;5(8):e1000559
Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response.
Kummer JA, Broekhuizen R, Everett H, Agostini L, Kuijk L, Martinon F, van Bruggen R, Tschopp J
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007 May;55(5):443-52
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007 May;55(5):443-52
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.
Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, Tschopp J
Immunity 2004 Mar;20(3):319-25
Immunity 2004 Mar;20(3):319-25
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Supportive validation
- Submitted by
- Enzo Life Sciences (provider)
- Main image
- Experimental details
- Staining of endogenous NLRP3/NALP3 in epithelial layer of human tonsil (frozen section) using NLRP3/NALP3 (human), mAb (Nalpy3-b) (Prod. No. ALX-804-819). Method: 5µM frozen section of tissue are dried and fixed with aceton. Tissue is washed with PBS and incubated with NLRP3/NALP3 (human), mAb (Nalpy3-b). Picture courtesy of Dr. Alain Kummer, University Medical Center Utrecht, The Netherlands.