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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [1]
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- Validations
- Immunohistochemistry [1]
- Other assay [1]
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- Product number
- PA5-51406 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- PHF14 Polyclonal Antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full-length protein
- Description
- Immunogen sequence: AQKEGLLSEA AAEEDIADPF FAYCKQHADR LDRKWKRKNY LALQSYCKMS LQEREKQLSP EAQARINARL QQYRAKAELA RSTRPQAWVP REKLPRPLTS SASAIRKLMR KAELMGISTD IF
- Concentration
- 0.05 mg/mL
Submitted references Silencing expression of PHF14 in glioblastoma promotes apoptosis, mitigates proliferation and invasiveness via Wnt signal pathway.
Wu S, Luo C, Li F, Hameed NUF, Jin Q, Zhang J
Cancer cell international 2019;19:314
Cancer cell international 2019;19:314
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemical staining of PHF14 in human colon tissue shows strong nuclear positivity in glandular cells. Samples were probed using a PHF14 Polyclonal Antibody (Product # PA5-51406).
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Fig. 1 PHF14 is overexpressed in glioblastoma multiforme (GBM) and lower PHF14 expression correlates with better outcome in GBM and LGG. a The cellular location of PHF14 confirmed by immunofluorescence (Scale bar = 50 mum). b Representative stainings of PHF14 in normal brain, grade II, grade III and grade IV glioma (Scale bar = 50 mum). c Correlation of the staining intensity of PHF14 with glioma grade. d - f Correlation of PHF14 mRNA expression with increasing WHO glioma grade according to REMBRANDT, TCGA and FRENCH data. g , h The relationship between PHF14 mRNA expression and molecular pathology of glioma. i , j Upregulation of PHF14 is a dismal prognostic factor in LGG by TCGA database. k Upregulation of PHF14 is a dismal prognostic factor in GBM by REMBRANDT database (*P < 0.05; **P = 0.01; ***P < 0.001; ****P < 0.0001)
