EGFL6

This gene encodes a member of the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. The gene product contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an arg-gly-asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. This gene is expressed early during development, and its expression has been detected in lung and meningioma tumors. [provided by RefSeq, Jul 2008]

Description

EGF like domain multiple 6

Tissue specificity

Tissue enriched (placenta)

Predicted location

Secreted to extracellular matrix

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

X (13569601 - 13633575)

Ensembl ID

ENSG00000198759  (ver. 103.38)

Orthologs

Mouse Egfl6: ENSMUSG00000000402

UniProt

Q8IUX8

neXtProt

NX_Q8IUX8

Human splice variants
Mouse splice variants

Protein structure