23016-1-AP

antibody from Proteintech Group

Targeting: SCN5A CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, Nav1.5, PFHB1, SSS1

Provider product page for 23016-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [18]
Comments [0]
Validations [0]

Submit

Product number: 23016-1-AP - Provider product page
Provider: Proteintech Group
Product name: Nav1.5 antibody
Antibody type: Polyclonal
Description: Nav1.5 antibody (Cat. #23016-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SCN5A protein structure - 23016-1-AP shown in red.

Submitted references SCN5A (c.4720G> A): a rare genetic variant associated with familial sick sinus syndrome and sudden cardiac death.

Sheng M, Zheng H, Zhang L, Li K, Han X, Yu Y, Yu Y, Zhao S, Chen P, Qian W, Wang J, Wang K, Chen F
International journal of legal medicine 2026 Mar 7;

Functional Characterization of the SCN5A p.D372H Variant Associated with Brugada Syndrome.

Xie X, He Y, Chen Y, Li Z, Sun Y, Chen G
Biomedicines 2026 Mar 5;14(3)

NMDA-Type Glutamate Receptor Activation Promotes Ischemic Arrhythmias by Targeting the AKT1-TBX3-Nav1.5 Axis.

He Y, Zhang H, Zhang Q, Sun Z, Sun X, Xia L, Zheng L, Wang L
Acta physiologica (Oxford, England) 2025 Sep;241(9):e70085

The local anesthetic, lidocaine, suppresses the growth of colon cancer SW480 cells by decreasing the voltage-gated sodium channel subunit Na(v)1.5.

Haraguchi-Suzuki K, Suzuki T, Nakasone C, Kawabata-Iwakawa R, Saito S
Scientific reports 2025 Nov 22;15(1):45018

Rescue of Scn5a mis-splicing does not improve the structural and functional heart defects of a DM1 heart mouse model.

Nitschke L, Hu RC, Miller AN, Cooper TA
Human molecular genetics 2024 Oct 7;33(20):1789-1799

Role of protein domains in trafficking and localization of the voltage-gated sodium channel β2 subunit.

Cortada E, Brugada R, Verges M
The Journal of biological chemistry 2024 Nov;300(11):107833

Hepatitis B virus-mediated sodium influx contributes to hepatic inflammation via synergism with intrahepatic danger signals.

Wang J, Liu Q, Zhou Y, Cao C, Chen P, Meng G, Zhang J, Xin X, Huang G, Wu Y
iScience 2024 Jan 19;27(1):108723

HAND factors regulate cardiac lineage commitment and differentiation from human pluripotent stem cells.

Guo H, Hang C, Lin B, Lin Z, Xiong H, Zhang M, Lu R, Liu J, Shi D, Xie D, Liu Y, Liang D, Yang J, Chen YH
Stem cell research & therapy 2024 Feb 5;15(1):31

Salidroside treatment decreases the susceptibility of atrial fibrillation in diabetic mice by reducing mTOR-STAT3-MCP-1 signaling and atrial inflammation.

Ren W, Huang Y, Meng S, Cao Z, Qin N, Zhao J, Huang T, Guo X, Chen X, Zhou Z, Zhu Y, Yu L, Wang H
International immunopharmacology 2024 Dec 5;142(Pt B):113196

Sialyltransferase ST3GAL4 confers osimertinib resistance and offers strategies to overcome resistance in non-small cell lung cancer.

Han R, Lin C, Lu C, Wang Y, Kang J, Hu C, Dou Y, Wu D, He T, Tang H, Zheng J, Li L, He Y
Cancer letters 2024 Apr 28;588:216762

Spider venom-derived peptide JZTX-14 prevents migration and invasion of breast cancer cells via inhibition of sodium channels.

Wu W, Yin Y, Feng P, Chen G, Pan L, Gu P, Zhou S, Lin F, Ji S, Zheng C, Deng M
Frontiers in pharmacology 2023;14:1067665

Alterations in Calcium Handling Are a Common Feature in an Arrhythmogenic Cardiomyopathy Cell Model Triggered by Desmosome Genes Loss.

Vallverdú-Prats M, Carreras D, Pérez GJ, Campuzano O, Brugada R, Alcalde M
International journal of molecular sciences 2023 Jan 20;24(3)

Glucose fluctuations aggravated the late sodium current induced ventricular arrhythmias via the activation of ROS/CaMKII pathway.

Li F, Qian LL, Wu LD, Zhang ZY, Zhang L, Liu HH, Zhao N, Zhang J, Chen JY, Yang F, Zhang ZY, Wang C, Dang SP, Zhao XX, Li KL, Zhu WQ, Yao Y, Wang RX
European journal of pharmacology 2023 Dec 15;961:176167

Mice lacking MBNL1 and MBNL2 exhibit sudden cardiac death and molecular signatures recapitulating myotonic dystrophy.

Lee KY, Seah C, Li C, Chen YF, Chen CY, Wu CI, Liao PC, Shyu YC, Olafson HR, McKee KK, Wang ET, Yeh CH, Wang CH
Human molecular genetics 2022 Sep 10;31(18):3144-3160

Moricizine prevents atrial fibrillation by late sodium current inhibition in atrial myocytes.

Zou T, Chen Q, Chen C, Liu G, Ling Y, Pang Y, Xu Y, Cheng K, Zhu W, Wang RX, Qian LL, Ge J
Journal of thoracic disease 2022 Jun;14(6):2187-2200

Changes in ion channel expression and function associated with cardiac arrhythmogenic remodeling by Sorbs2.

Qian LL, Sun X, Yang J, Wang XL, Ackerman MJ, Wang RX, Xu X, Lee HC, Lu T
Biochimica et biophysica acta. Molecular basis of disease 2021 Dec 1;1867(12):166247

Scorpion Venom Analgesic Peptide, BmK AGAP Inhibits Stemness, and Epithelial-Mesenchymal Transition by Down-Regulating PTX3 in Breast Cancer.

Kampo S, Ahmmed B, Zhou T, Owusu L, Anabah TW, Doudou NR, Kuugbee ED, Cui Y, Lu Z, Yan Q, Wen QP
Frontiers in oncology 2019;9:21

Mechanistic insights into the interaction of the MOG1 protein with the cardiac sodium channel Na(v)1.5 clarify the molecular basis of Brugada syndrome.

Yu G, Liu Y, Qin J, Wang Z, Hu Y, Wang F, Li Y, Chakrabarti S, Chen Q, Wang QK
The Journal of biological chemistry 2018 Nov 23;293(47):18207-18217

No comments: Submit comment

No validations: Submit validation data