SLC24A2

This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Description

Solute carrier family 24 member 2

Tissue specificity

Tissue enriched (brain)

Subcell location

Plasma membrane

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

9 (19507452 - 19786928)

Ensembl ID

ENSG00000155886  (ver. 103.38)

Orthologs

Mouse Slc24a2: ENSMUSG00000037996

UniProt

Q9UI40

neXtProt

NX_Q9UI40

Human splice variants
Mouse splice variants

Protein structure