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- References [227]
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- Product number
- 18592-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18592-1-AP, RRID:AB_10860103
- Product name
- FOXO1 antibody
- Antibody type
- Polyclonal
- Description
- FOXO1 antibody (Cat. #18592-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Ulinastatin attenuates capillary leakage and suppresses FoxO1-dependent angiopoietin-2 in sepsis-associated acute lung injury via PI3K pathway.
Canonical BAF chromatin remodeling complex specifies stem cell fate via cell-type-specific co-factor recruitment.
Photobiomodulation therapy reduces diabetic periodontal damage through modulation of macrophage metabolism and functions.
Dual regulation of CXCR6(+)CD8(+) T cells modulates cytotoxic and exhaustion-associated programs during prostate cancer progression.
DNA tetrahedron-mediated vascular targeted delivery of astragaloside IV enhances distraction osteogenesis via PI3K/AKT/FOXO pathway.
TAZ alleviates ischemic stroke injury by activating Foxo1: Usp1-mediated deubiquitination is the pivotal mechanism.
Di-(2-ethylhexyl) phthalate exposure disrupts glucose homeostasis through inhibition of PI3K/Akt/FoxO1 pathway triggering β-cell dedifferentiation in male rats.
The role of FOXO1/PPARγ in atrazine-induced hepatic lipid metabolism disorders.
SIRT1 Regulates Iron Metabolism to Attenuate β-Cell Dedifferentiation by Inhibiting FoxO1 Acetylation.
BMSC-derived exosomes facilitate osteogenesis and ameliorate ageing-related bone loss through restoring Th17/Treg homeostasis via the miR-21/Skp2/FoxO1 axis.
Sodium butyrate ameliorates muscle atrophy in type 2 diabetes-related sarcopenia via the PI3K/Akt/FoxO1 pathway.
Targeting Egfr-Mediated Cell Proliferation and Lipid Metabolism Separation Effectively Accelerate Liver Regeneration.
Activation of central Angiotensin-(1-7)/Mas receptor alleviates synaptic damage in diabetes-associated cognitive impairment via modulating AKT/FOXO1/PACAP axis.
4'-Methoxyresveratrol Improves Hepatic Insulin Resistance Induced by a High-Fat-Diet via Anti-Oxidative-Stress Activity.
Fu-Fang-Qi-Di-Hua-Yu-Tang Improves Diabetic Macrovascular Disease via PI3K/AKT Pathway Regulation.
miR-223 alleviates DSS-induced colitis by prompting macrophage M2 polarization through PPAR-γ/FOXO1 signaling.
Ophiopogonin D improves pancreatic islet cell dedifferentiation to treat diabetes by regulating the GRP78/ROS/PDX1 signaling pathway.
Akkermansia muciniphila ameliorates olanzapine-induced metabolic dysfunction-associated steatotic liver disease via PGRMC1/SIRT1/FOXO1 signaling pathway.
An anti-FAP-scFv-functionalized exosome-carrying hydrogel delivers SKI mRNA to fibrotic nucleus pulposus cells to alleviate intervertebral disc degeneration by regulating FOXO3.
Neuroprotection in spinal cord ischemia-reperfusion injury: Diosmetin's role via TREM2-mediated microglial pyroptosis.
Functional characterization of promoter regions in selenoprotein synthesis-relevant genes (sbp2, eefsec and sepsecs) and their selenium-dependent regulation in yellow catfish Pelteobagrus fulvidraco.
HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF-κB/SOD2 Signaling Pathway.
Danggui Buxue Decoction inhibits pulmonary fibrosis by alleviating TGF-β1-induced proliferation and apoptosis in EBL cells via PI3K/AKT/FOXO1 pathway.
Identification and characterization of a potent peptide inhibitor targeting FOXM1 in cancer therapy.
Effect of rumen-protected guanidinoacetic acid provision as a dietary supplement on the growth, slaughter performance, and meat quality in simmental bulls.
Lithium Exposure Causes Trophoblast Cuproptosis by Upregulating FOXO1/STEAP4 Axis in Unexplained Miscarriage.
Lipidomics Revealed the Suppression of 5-PAHSA from Human Milk on Macrophage Foam Cell Formation.
O-GlcNAc transferase influences the progression of degenerative cartilage disease in lumbar facet joint osteoarthritis through FoxO1 and EGR1.
Nicotinamide mononucleotide rescues Di-n-butyl phthalate induced blood-brain barrier damage via NAD(+)/Sirt1/FOXO1a pathway activation.
Circular RNA circDhx32 promotes cardiac inflammatory responses in mouse cardiac ischemia-reperfusion injury via binding to FOXO1 competed with AdipoR1.
Polystyrene nanoplastics impair endometrial decidualization via cell cycle arrest and JNK-MAPK pathway-mediated oxidative stress in early pregnant mice.
MDMX reprograms glycolysis of hepatocellular carcinoma via 14-3-3γ/FOXO1.
Downregulation of PDIA4 inhibits proliferation and migration in human oral squamous cell carcinoma.
FSH-Induced Nuclear Exclusion of FOXO1 Mediated by PI3K/Akt Signaling Pathway in Granulosa Cells Is Associated with Follicle Selection and Growth of the Hen Ovary.
Microenvironment-responsive multifunctional enzyme-linked hydrogel for diabetic bone defect regeneration.
Omentin-1 promotes wound healing in diabetic mice by improving vascular endothelial cell function.
Associations between FOXO1 expression in tissue, the pathological characteristics of colorectal cancer, and patient survival.
Astragaloside IV prevents liver fibrosis by blocking glycolysis-mediated macrophage M1 polarization.
Endoplasmic reticulum stress and forkhead box protein O1 inhibition mediate palmitic acid and high glucose-induced β-cell dedifferentiation.
Psychological stress-induced systemic corticosterone directly sabotages intestinal stem cells and exacerbates colitis.
miR-138-5p inhibits healing of femoral fracture osteogenesis in rats by modulating osteoblast differentiation via SIRT1/FOXO1 axis.
Harnessing engineered exosomes as METTL3 carriers: Enhancing osteogenesis and suppressing lipogenesis in bone marrow mesenchymal stem cells for postmenopausal osteoporosis treatment.
Ginsenoside Rk1 Ameliorates Non-Alcoholic Fatty Liver Disease by Targeting CD36 to Modulate the AMPK Signaling Pathway.
Luteolin Potentially Alleviates Methamphetamine Withdrawal-Induced Negative Emotions and Cognitive Deficits Through the AKT/FOXO1/HO-1 Signaling Pathway in the Prefrontal Cortex and Caudate Putamen.
FOXO1 contributes to cigarette smoke condensate-induced cellular senescence and fibrosis in lung fibroblasts through activating the TGF-β1/Smad2/3 signaling pathway.
Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy.
MET promotes hepatocellular carcinoma development through the promotion of TRIB3-mediated FOXO1 degradation.
Rosmarinic Acid Ameliorates Type 2 Diabetic Osteoporosis by Reducing NLRP3 Expression and Alleviating Osteoblast Pyroptosis via the FOXO1/TXNIP Signaling Pathway.
Kushenol I combats ulcerative colitis via intestinal barrier preservation and gut microbiota optimization.
Rspo3-mediated metabolic liver zonation regulates systemic glucose metabolism and body mass in mice.
Aberrant TCF21 upregulation in adenomyosis impairs endometrial decidualization by increasing PDE4C expression.
Network pharmacology, transcriptomics, and biological validation reveal a lipid secretion inhibitory and anti-inflammatory mechanism of tanreqing gel in the treatment of acne.
HouShiHeiSan attenuates sarcopenia in middle cerebral artery occlusion (MCAO) rats.
SIRT6 knockdown alleviates keratinocyte hyperproliferation and inflammation in psoriasis via modulating acetylation of FOXO1.
YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies.
Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice.
Developmental exposure to perfluorooctane sulfonate(PFOS) impairs the endometrial receptivity.
NCAPD3-mediated AKT activation regulates prostate cancer progression.
Proline exacerbates hepatic gluconeogenesis via paraspeckle-dependent mRNA retention.
Doxorubicin-loaded PEGylated liposome modified with ANGPT2-specific peptide for integrative glioma-targeted imaging and therapy.
Semaglutide Mitigates Ischemic Brain Injury by Inhibiting Ferroptosis via Modulation of FoXO1 and DRP1 Pathways.
Enhanced FOXO1 expression as a predictor of decitabine response and prolonged survival in high-risk myelodysplastic syndrome.
Tauroursodeoxycholic acid ameliorates palmitic acid induced endoplasmic reticulum stress and impaired autophagy via IRE1- XBP1-FoxO1 pathway in KGN cells.
Fast Myosin Binding Protein-C Is a Vital Regulator in Young and Aged Fast Skeletal Muscle Homeostasis.
Targeting FoxO1-STX17-mediated autophagic flux: Quercetin's therapeutic mechanism in diabetic nephropathy.
FTO-mediated m6A modification regulates the osteogenic differentiation of ADSCs by targeting FOXO1.
Hepatic metabolic reprogramming in male mice during short-term caloric restriction involves enhanced glucocorticoid rhythms.
Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1.
EGCG and Taurine Synergistically Ameliorate Lipid Metabolism Disorder by Modulating Gut Microbiota and PPARα/FAS Signaling Pathway.
Galectin-3-integrin α5β1 phase separation disrupted by advanced glycation end-products impairs diabetic wound healing in rodents.
Mild hypothermia attenuates hepatic ischemia-reperfusion injury by regulating FoxO1/PPARα pathway.
Oxaloacetate promotes the transition from glycolysis to gluconeogenesis through the Akt-FoxO1 and JNK/c-Jun-FoxO1 axes and inhibits the survival of liver cancer cells.
The study of JAZF1-mediated apoptosis of decidual stromal cells by activating the NF-κB signaling pathway in spontaneous preterm birth.
CircRNA (circ)_0007823 Contributes to Triple-Negative Breast Cancer Progression and Cisplatin Resistance via the miR-182-5p/FOXO1 Pathway.
Upregulation of FAM129B protects against glucocorticoid-induced skeletal muscle atrophy via regulating long non-coding RNA NEAT1.
Decidual Disrupting Effects of Low-Dose Benzophenone-Type UV Filters in Human Endometrial Stromal Cells via ER/PR/FOXO1 Signaling.
Integrated Network Pharmacology and in vivo Experimental Validation Approach to Explore the Potential Antioxidant Effects of Annao Pingchong Decoction in Intracerebral Hemorrhage Rats.
Network Pharmacology-Based Strategy to Explore the Effect and Mechanism of Zhizhu Granule Improving Glucose-Lipid Metabolism in Rats with Metabolic Syndrome.
THSR Mediated MiR374b Targeting C/EBP β/FOXO1 to Accelerate Thyroid Stimulating Hormone-Induced Hepatic Steatosis.
CREG1 attenuates doxorubicin-induced cardiotoxicity by inhibiting the ferroptosis of cardiomyocytes.
Gentiopicroside ameliorates glucose and lipid metabolism in T2DM via targeting FGFR1.
A metabolic atlas of blood cells in young and aged mice identifies uridine as a metabolite to rejuvenate aged hematopoietic stem cells.
Neurons enhance blood-brain barrier function via upregulating claudin-5 and VE-cadherin expression due to glial cell line-derived neurotrophic factor secretion.
CircGNAO1 suppresses hepatocellular carcinoma progression and metastasis via sponging miR-182-5p and regulating FOXO1 expression.
Bifidobacterium lactis-Derived Vesicles Attenuate Hippocampal Neuroinflammation by Targeting IL-33 to Regulate FoxO6/P53 Signaling.
FOXO1-mTOR pathway in vascular pericyte regulates the formation of type H vessels to control bone metabolism.
PXD101 inhibits malignant progression and radioresistance of glioblastoma by upregulating GADD45A.
Acetylation of FOXO1 is involved in cadmium-induced rat kidney injury via mediating autophagosome-lysosome fusion blockade and autophagy inhibition.
The P300-ARRDC3 axis participates in maternal subclinical hypothyroidism and is involved in abnormal hepatic insulin sensitivity in adult offspring.
Sorcin promotes proliferation of hepatocellular carcinoma by regulating VEGFA/B via PI3K pathway.
Eicosapentaenoic acid-mediated activation of PGAM2 regulates skeletal muscle growth and development via the PI3K/AKT pathway.
Lycopene Promotes Osteogenesis and Reduces Adipogenesis through Regulating FoxO1/PPARγ Signaling in Ovariectomized Rats and Bone Marrow Mesenchymal Stem Cells.
Lipoteichoic acid restrains macrophage senescence via β-catenin/FOXO1/REDD1 pathway in age-related osteoporosis.
Linoleic acid induces human ovarian granulosa cell inflammation and apoptosis through the ER-FOXO1-ROS-NFκB pathway.
Echinacoside alleviates glucocorticoid induce osteonecrosis of femoral head in rats through PI3K/AKT/FOXO1 pathway.
Elucidation of the anti-β-cell dedifferentiation mechanism of a modified Da Chaihu Decoction by an integrative approach of network pharmacology and experimental verification.
Long-chain acyl-CoA synthetase-4 regulates endometrial decidualization through a fatty acid β-oxidation pathway rather than lipid droplet accumulation.
CAPN2 promotes apalutamide resistance in metastatic hormone-sensitive prostate cancer by activating protective autophagy.
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK.
GSK2334470 attenuates high salt-exacerbated rheumatoid arthritis progression by restoring Th17/Treg homeostasis.
Overexpression of FHL1 suppresses papillary thyroid cancer proliferation and progression via inhibiting Wnt/β-catenin pathway.
DDX20 is required for cell-cycle reentry of prospermatogonia and establishment of spermatogonial stem cell pool during testicular development in mice.
The protective effects of aqueous extract of Schisandra sphenanthera against alcoholic liver disease partly through the PI3K-AKT-IKK signaling pathway.
Microglial FoxO3a deficiency ameliorates ferroptosis-induced brain injury of intracerebral haemorrhage via regulating autophagy and heme oxygenase-1.
Decreased FoxO1 expression contributes to facet joint osteoarthritis pathogenesis by impairing chondrocyte migration and extracellular matrix synthesis.
EGF-driven EGFR/miR-27b-3p/FOXO1 promotes rat FSH synthesis and secretion.
Txnip promotes autophagic apoptosis in diabetic cardiomyopathy by upregulating FoxO1 and its acetylation.
Ginkgolide A enhances FoxO1 expression and reduces endoplasmic reticulum stress to mitigate osteoarthritis in mice.
Oligomeric Proanthocyanidins Ameliorate Cadmium-Induced Senescence of Osteocytes Through Combating Oxidative Stress and Inflammation.
Sleep deprivation induced fat accumulation in the visceral white adipose tissue by suppressing SIRT1/FOXO1/ATGL pathway activation.
Osthole exhibits the remedial potential for polycystic ovary syndrome mice through Nrf2-Foxo1-GSH-NF-κB pathway.
The FOXO1/G6PC axis promotes gastric cancer progression and mediates 5-fluorouracil resistance by targeting the PI3K/AKT/mTOR signaling pathway.
Baicalin Maintains Articular Cartilage Homeostasis and Alleviates Osteoarthritis by Activating FOXO1.
Phytic acid promotes high glucose-mediated bone marrow mesenchymal stem cells osteogenesis via modulating circEIF4B that sponges miR-186-5p and complexes with IGF2BP3.
Resistance exercise preconditioning prevents disuse muscle atrophy by inhibiting apoptosis and protein degradation via SESN2 in C57BL/6J mice.
Effect of beta-cypermethrin on the reproductive capacity of female mice in advanced age.
Diterpenoid tanshinones inhibit gastric cancer angiogenesis through the PI3K/Akt/mTOR signaling pathway.
Angiotensin (1-7) reverses glucose-induced islet β cell dedifferentiation by Wnt/β-catenin/FoxO1 signalling pathway.
Study on the Mechanism of Jiaotai Pill Intervention on Insomnia Animal Model Based on Gut Microbiome and Metabolomics.
Hsa_circ_0007823 Overexpression Suppresses the Progression of Triple-Negative Breast Cancer via Regulating miR-182-5p-FOXO1 Axis.
The downstream network of STAT6 in promoting vascular smooth muscle cell phenotypic switch and neointimal formation.
Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis.
FoxO1 is a negative regulator of neointimal hyperplasia in a rat model of patch angioplasty.
miR-552 promotes the proliferation and metastasis of intrahepatic cholangiocarcinoma by targeting FOXO1.
Role of SIRT2 in intestinal barrier under cold exposure.
MiR-337-3p improves metabolic-associated fatty liver disease through regulation of glycolipid metabolism.
Hexavalent chromium caused DNA damage repair and apoptosis via the PI3K/AKT/FOXO1 pathway triggered by oxidative stress in the lung of rat.
Douchi Peptides VY and SFLLR Improve Glucose Homeostasis and Gut Dysbacteriosis in High-Fat Diet-Induced Insulin Resistant Mice.
The therapeutic mechanism of Yuye decoction on type 2 diabetes mellitus based on network pharmacology and experimental verification.
Toxicity mechanism of peri-implantation pesticide beta-cypermethrin exposure on endometrial remodeling in early pregnant mice.
Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila.
miR-484 mediates oxidative stress-induced ovarian dysfunction and promotes granulosa cell apoptosis via SESN2 downregulation.
Neuro death through autophagy via the acetylation of FoxO1 by SIRT2 in the hippocampus of mice in a autism spectrum disorder mice model.
"Biqi" Bayberry Extract Promotes Skeletal Muscle Fiber Type Remodeling by Increasing Fast Myofiber Formation via the Akt/FoxO1 Pathway in Mice.
Exercise mitigates Dapagliflozin-induced skeletal muscle atrophy in STZ-induced diabetic rats.
The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region.
PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A-producing γδ T cells.
Toxicity assessment of organophosphate flame retardant triphenyl phosphate (TPHP) on intestines in mice.
[m(6)A methylase WTAP participates in renal ischemia-reperfusion injury by regulating FOXO1 expression].
Methionine supplementation spares body protein by regulating the expression of mTORC1 downstream factors in rats fed a soy protein diet with sufficient sulfur amino acids: a pilot study.
Ginkgolide A targets forkhead box O1 to protect against lipopolysaccharide-induced septic cardiomyopathy.
Targeted long-term noninvasive treatment of choroidal neovascularization by biodegradable nanoparticles.
The 15-hydroxyprostaglandin dehydrogenase inhibitor SW033291 ameliorates abnormal hepatic glucose metabolism through PGE(2)-EP4 receptor-AKT signaling in a type 2 diabetes mellitus mouse model.
Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function.
Ursolic Acid Alleviates Cancer Cachexia and Prevents Muscle Wasting via Activating SIRT1.
Silencing CAMK2D Promotes the Proliferation of Spermatogonia in the Testis of Experimental Varicocele Rats.
Lignans from Mosla scabra Ameliorated Influenza A Virus-Induced Pneumonia via Inhibiting Macrophage Activation.
HB-EGF induces mitochondrial dysfunction via estrogen hypersecretion in granulosa cells dependent on cAMP-PKA-JNK/ERK-Ca(2+)-FOXO1 pathway.
Oridonin Delays Aging Through the AKT Signaling Pathway.
ALG-bFGF Hydrogel Inhibiting Autophagy Contributes to Protection of Blood-Spinal Cord Barrier Integrity via PI3K/Akt/FOXO1/KLF4 Pathway After SCI.
Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway.
Feeding desensitizes A1 adenosine receptors in adipose through FOXO1-mediated transcriptional regulation.
Hepatic p53 is regulated by transcription factor FOXO1 and acutely controls glycogen homeostasis.
Icaritin inhibits CDK2 expression and activity to interfere with tumor progression.
Cold exposure-induced endoplasmic reticulum stress regulates autophagy through the SIRT2/FoxO1 signaling pathway.
Recombinant Humanized IgG1 Antibody Protects against oxLDL-Induced Oxidative Stress and Apoptosis in Human Monocyte/Macrophage THP-1 Cells by Upregulation of MSRA via Sirt1-FOXO1 Axis.
Spindle and kinetochore-associated complex 3 promotes cell growth via the PI3K/AKT/GSK3β and PI3K/AKT/FOXO1 pathways and is a potential prognostic biomarker for oral squamous cell carcinoma.
O-GlcNAcylation of SIRT1 Protects against Cold Stress-Induced Skeletal Muscle Damage via Amelioration of Mitochondrial Homeostasis.
DEAD-box helicase 56 functions as an oncogene promote cell proliferation and invasion in gastric cancer via the FOXO1/p21 Cip1/c-Myc signaling pathway.
LncRNA SNHG8 sponges miR-449c-5p and regulates the SIRT1/FoxO1 pathway to affect microglia activation and blood-brain barrier permeability in ischemic stroke.
The protective effects of butorphanol tartrate against homocysteine-induced blood-brain barrier dysfunction.
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Aerobic exercise promotes the expression of ATGL and attenuates inflammation to improve hepatic steatosis via lncRNA SRA.
FoxO1 Regulates Neuropeptide Y and Pro-opiomelanocortin in the Hypothalamus of Rat Offspring Small for Gestational Age.
SDF-1 inhibits the dedifferentiation of islet β cells in hyperglycaemia by up-regulating FoxO1 via binding to CXCR4.
LncRNA nuclear receptor subfamily 2 group F member 1 antisense RNA 1 (NR2F1-AS1) aggravates nucleus pulposus cell apoptosis and extracellular matrix degradation.
HDAC9 Contributes to Serous Ovarian Cancer Progression through Regulating Epithelial-Mesenchymal Transition.
Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy.
6-Hydroxydopamine-Induced Neurotoxicity in Rat Model of Parkinson's Disease: Is Reversed via Anti-Oxidative Activities of Curcumin and Aerobic Exercise Therapy.
miR-486 attenuates cardiac ischemia/reperfusion injury and mediates the beneficial effect of exercise for myocardial protection.
Genetic and Functional Evaluation of the Role of FOXO1 in Antituberculosis Drug-Induced Hepatotoxicity.
Clozapine Induced Disturbances in Hepatic Glucose Metabolism: The Potential Role of PGRMC1 Signaling.
Targeting Wnt Signaling in the Tumor Immune Microenvironment to Enhancing EpCAM CAR T-Cell therapy.
EZH2-Mediated microRNA-375 Upregulation Promotes Progression of Breast Cancer via the Inhibition of FOXO1 and the p53 Signaling Pathway.
TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway.
Genistein exhibits therapeutic potential for PCOS mice via the ER-Nrf2-Foxo1-ROS pathway.
Activation of angiotensin-converting enzyme 2/angiotensin (1-7)/mas receptor axis triggers autophagy and suppresses microglia proinflammatory polarization via forkhead box class O1 signaling.
Comparative analysis of long non‑coding RNA expression profiles induced by resveratrol and metformin treatment for hepatic insulin resistance.
1,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice.
Hawthorn polyphenols, D-chiro-inositol, and epigallocatechin gallate exert a synergistic hypoglycemic effect.
Circular RNA ubiquitin-associated protein 2 enhances autophagy and promotes colorectal cancer progression and metastasis via miR-582-5p/FOXO1 signaling.
FOXO1 inhibits prostate cancer cell proliferation via suppressing E2F1 activated NPRL2 expression.
PPP2R2A affects embryonic implantation by regulating the proliferation and apoptosis of Hu sheep endometrial stromal cells.
Magnesium Lithospermate B Attenuates High-Fat Diet-Induced Muscle Atrophy in C57BL/6J Mice.
Resveratrol Promotes Angiogenesis in a FoxO1-Dependent Manner in Hind Limb Ischemia in Mice.
circEVI5 acts as a miR-4793-3p sponge to suppress the proliferation of gastric cancer.
Liver kinase B1 attenuates liver ischemia/reperfusion injury via inhibiting the NLRP3 inflammasome.
FOXO1 and hsa-microRNA-204-5p affect the biologic behavior of MDA-MB-231 breast cancer cells.
Resveratrol Upregulates mmu-miR-363-3p via the PI3K-Akt Pathway to Improve Insulin Resistance Induced by a High-Fat Diet in Mice.
Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1.
FUT4siRNA augments the chemosensitivity of non-small cell lung cancer to cisplatin through activation of FOXO1-induced apoptosis.
Activation of Sirtuin1 by lyceum barbarum polysaccharides in protection against diabetic cataract.
Serpina3c protects against high-fat diet-induced pancreatic dysfunction through the JNK-related pathway.
CDKL3 promotes osteosarcoma progression by activating Akt/PKB.
Influence of feature rankers in the construction of molecular activity prediction models.
Tectorigenin attenuates diabetic nephropathy by improving vascular endothelium dysfunction through activating AdipoR1/2 pathway.
MSC-Secreted Exosomal H19 Promotes Trophoblast Cell Invasion and Migration by Downregulating let-7b and Upregulating FOXO1.
Using ESTIMATE algorithm to establish an 8-mRNA signature prognosis prediction system and identify immunocyte infiltration-related genes in Pancreatic adenocarcinoma.
The Human Novel Gene LNC-HC Inhibits Hepatocellular Carcinoma Cell Proliferation by Sequestering hsa-miR-183-5p.
Electroacupuncture ameliorates cerebral ischemia/reperfusion injury by suppressing autophagy via the SIRT1-FOXO1 signaling pathway.
LncRNA MBNL1-AS1 represses cell proliferation and enhances cell apoptosis via targeting miR-135a-5p/PHLPP2/FOXO1 axis in bladder cancer.
Tamoxifen induces fatty liver disease in breast cancer through the MAPK8/FoxO pathway.
Calcium relieves fluoride-induced bone damage through the PI3K/AKT pathway.
Long non-coding RNA expression profiling following treatment with resveratrol to improve insulin resistance.
Self-Therapeutic Nanoparticle That Alters Tau Protein and Ameliorates Tauopathy Toward a Functional Nanomedicine to Tackle Alzheimer's.
MiR-21-3p Plays a Crucial Role in Metabolism Alteration of Renal Tubular Epithelial Cells during Sepsis Associated Acute Kidney Injury via AKT/CDK2-FOXO1 Pathway.
Resveratrol affects hepatic gluconeogenesis via histone deacetylase 4.
Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal.
Partially Hydrolyzed Guar Gum Attenuates d-Galactose-Induced Oxidative Stress and Restores Gut Microbiota in Rats.
Anti-ageing and antioxidant effects of sulfate oligosaccharides from green algae Ulva lactuca and Enteromorpha prolifera in SAMP8 mice.
Young Blood Rescues the Cognition of Alzheimer's Model Mice by Restoring the Hippocampal Cholinergic Circuit.
Promising therapeutic effect of thapsigargin nanoparticles on chronic kidney disease through the activation of Nrf2 and FoxO1.
Sweroside Alleviated LPS-Induced Inflammation via SIRT1 Mediating NF-κB and FOXO1 Signaling Pathways in RAW264.7 Cells.
Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol.
Oxaliplatin reverses the GLP-1R-mediated promotion of intrahepatic cholangiocarcinoma by altering FoxO1 signaling.
Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells.
Glutathione prevents chronic oscillating glucose intake-induced β-cell dedifferentiation and failure.
Identification of the key genes and pathways in prostate cancer.
AMPK alleviates endoplasmic reticulum stress by inducing the ER-chaperone ORP150 via FOXO1 to protect human bronchial cells from apoptosis.
Japanese encephalitis virus induces apoptosis by inhibiting Foxo signaling pathway.
Amino acid starvation-induced autophagy is involved in reduced subcutaneous fat deposition in weaning piglets derived from sows fed low-protein diet during gestation and lactation : Autophagy is involved in reduced fat deposition in maternal low-protein piglets.
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.
High glucose induces apoptosis via upregulation of Bim expression in proximal tubule epithelial cells.
RGD liposome-protamine-siRNA (LPR) nanoparticles targeting PAX3-FOXO1 for alveolar rhabdomyosarcoma therapy.
MicroRNA-96 plays an oncogenic role by targeting FOXO1 and regulating AKT/FOXO1/Bim pathway in papillary thyroid carcinoma cells.
VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in caenorhabditis elegans.
Caffeic acid phenethyl ester synergistically enhances docetaxel and paclitaxel cytotoxicity in prostate cancer cells.
Lv Y, Meng Y, Rui H, Li T, Zhang J, Liu J, Ma X, Wang J, Yuan Y, Jiang Y, Yan X, Li M, Dong X, Zhang B, Ma L
PloS one 2026;21(4):e0348261
PloS one 2026;21(4):e0348261
Canonical BAF chromatin remodeling complex specifies stem cell fate via cell-type-specific co-factor recruitment.
Zhang M, Feng J, Guo T, Meng L, Pei F, Gao L, Yang Y, Ho TV, Chai Y
Nature communications 2026 Mar 3;17(1)
Nature communications 2026 Mar 3;17(1)
Photobiomodulation therapy reduces diabetic periodontal damage through modulation of macrophage metabolism and functions.
Abulizi P, Dong H, Cui A, Zou H, Sun Y, Nie L, Cui B, Xiao S, Ding Y, Leung WK, Wang Q
Lasers in medical science 2026 Mar 2;41(1)
Lasers in medical science 2026 Mar 2;41(1)
Dual regulation of CXCR6(+)CD8(+) T cells modulates cytotoxic and exhaustion-associated programs during prostate cancer progression.
Xingming Z, Wang J, Abudurexiti M, Du L, Zhang W, Ni X, Xu M, Zhang X, Zhang M, Yao Z, Bian X, Jin S, Wang W
Journal for immunotherapy of cancer 2026 Mar 11;14(3)
Journal for immunotherapy of cancer 2026 Mar 11;14(3)
DNA tetrahedron-mediated vascular targeted delivery of astragaloside IV enhances distraction osteogenesis via PI3K/AKT/FOXO pathway.
Feng Y, Fu H, Zhu P, Hong S, Shang Y, Chen Y, Wei H, Wu H, Huang X, Jiang W, Wang X
Biomaterials 2026 Jul;330:124040
Biomaterials 2026 Jul;330:124040
TAZ alleviates ischemic stroke injury by activating Foxo1: Usp1-mediated deubiquitination is the pivotal mechanism.
Xin Y, Sun Y, Pan E, Li M, Chen H, Xu Y, Zhang B, Shi Y, Dong J, Zhao P
Free radical biology & medicine 2026 Jul;250:548-563
Free radical biology & medicine 2026 Jul;250:548-563
Di-(2-ethylhexyl) phthalate exposure disrupts glucose homeostasis through inhibition of PI3K/Akt/FoxO1 pathway triggering β-cell dedifferentiation in male rats.
Shi D, Wang X, Zhao Y, Zhao L, Lu S, Wang J, Han H, Zhang Z
Toxicology 2026 Jan;519:154311
Toxicology 2026 Jan;519:154311
The role of FOXO1/PPARγ in atrazine-induced hepatic lipid metabolism disorders.
Yingchao H, Haoyan M, Zengchen W, Haotang Z, Tong L, Ying Q, Xiaotong W, Yuezhu Z
Toxicology letters 2026 Jan;415:111797
Toxicology letters 2026 Jan;415:111797
SIRT1 Regulates Iron Metabolism to Attenuate β-Cell Dedifferentiation by Inhibiting FoxO1 Acetylation.
Li T, Ma R, Tang W, Zheng Y, Lv S, Liu Y, Wang L, Ding Y
Biological trace element research 2026 Jan;204(1):453-465
Biological trace element research 2026 Jan;204(1):453-465
BMSC-derived exosomes facilitate osteogenesis and ameliorate ageing-related bone loss through restoring Th17/Treg homeostasis via the miR-21/Skp2/FoxO1 axis.
Wang Z, Luo J, Yu T, Hu P, Liu J
Stem cell research & therapy 2026 Feb 17;17(1)
Stem cell research & therapy 2026 Feb 17;17(1)
Sodium butyrate ameliorates muscle atrophy in type 2 diabetes-related sarcopenia via the PI3K/Akt/FoxO1 pathway.
Song CY, Yang Y, Hong K
Tissue & cell 2026 Aug;101:103487
Tissue & cell 2026 Aug;101:103487
Targeting Egfr-Mediated Cell Proliferation and Lipid Metabolism Separation Effectively Accelerate Liver Regeneration.
Hu Y, Song S, Wang R, An N, Diao J, Chen Y, Liu J, Lv G
Cell proliferation 2026 Apr 22;:e70214
Cell proliferation 2026 Apr 22;:e70214
Activation of central Angiotensin-(1-7)/Mas receptor alleviates synaptic damage in diabetes-associated cognitive impairment via modulating AKT/FOXO1/PACAP axis.
Tian S, Wu T, Zhang Z, Lv S, Ji X, Zhao Z, Ma X, Wang J, Bi Y
International journal of biological sciences 2025;21(6):2824-2842
International journal of biological sciences 2025;21(6):2824-2842
4'-Methoxyresveratrol Improves Hepatic Insulin Resistance Induced by a High-Fat-Diet via Anti-Oxidative-Stress Activity.
Zhang Z, Zhang X, Yang L, Nie Q, Song G
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:2739-2752
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:2739-2752
Fu-Fang-Qi-Di-Hua-Yu-Tang Improves Diabetic Macrovascular Disease via PI3K/AKT Pathway Regulation.
Zhang S, Yan M, Liang P, Zhang Y, Liu J, Huang H, Li G, Wu H
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:2247-2265
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:2247-2265
miR-223 alleviates DSS-induced colitis by prompting macrophage M2 polarization through PPAR-γ/FOXO1 signaling.
Zhang J, Wang L, Shen Y, Qian X, Wang Z, Wang C
Frontiers in immunology 2025;16:1598781
Frontiers in immunology 2025;16:1598781
Ophiopogonin D improves pancreatic islet cell dedifferentiation to treat diabetes by regulating the GRP78/ROS/PDX1 signaling pathway.
Sun H, Tan R, Sun Y, Li Y, Xie Y, Zhang C, Song J, Zhu W, Zhou J, Deng C, Mei M
Frontiers in pharmacology 2025;16:1563201
Frontiers in pharmacology 2025;16:1563201
Akkermansia muciniphila ameliorates olanzapine-induced metabolic dysfunction-associated steatotic liver disease via PGRMC1/SIRT1/FOXO1 signaling pathway.
Chen H, Cao T, Lin C, Jiao S, He Y, Zhu Z, Guo Q, Wu R, Cai H, Zhang B
Frontiers in pharmacology 2025;16:1550015
Frontiers in pharmacology 2025;16:1550015
An anti-FAP-scFv-functionalized exosome-carrying hydrogel delivers SKI mRNA to fibrotic nucleus pulposus cells to alleviate intervertebral disc degeneration by regulating FOXO3.
Li Y, Zhai Y, Wang T, Wang S, Tian Y, Bian Z, Zhang Y, Zhang C, Liu M, Li C
Theranostics 2025;15(9):3877-3899
Theranostics 2025;15(9):3877-3899
Neuroprotection in spinal cord ischemia-reperfusion injury: Diosmetin's role via TREM2-mediated microglial pyroptosis.
Liu S, Dong Y, Zhang X, Pan X, Wang R, Ma H, Sun N, Cao X
Free radical biology & medicine 2025 Sep;237:369-382
Free radical biology & medicine 2025 Sep;237:369-382
Functional characterization of promoter regions in selenoprotein synthesis-relevant genes (sbp2, eefsec and sepsecs) and their selenium-dependent regulation in yellow catfish Pelteobagrus fulvidraco.
Zhang K, Yu AG, Zheng H, Li PJ, Luo Z
Biochimica et biophysica acta. Gene regulatory mechanisms 2025 Sep;1868(3):195105
Biochimica et biophysica acta. Gene regulatory mechanisms 2025 Sep;1868(3):195105
HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF-κB/SOD2 Signaling Pathway.
Li H, Cai S, Mu H, Chang T, Wang X, Tang T, Dong T, Zhang Y, Zhang L, Li H, Zhou L, Xiang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e03828
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e03828
Danggui Buxue Decoction inhibits pulmonary fibrosis by alleviating TGF-β1-induced proliferation and apoptosis in EBL cells via PI3K/AKT/FOXO1 pathway.
Yang Z, Ji P, Zhang W, Li C, Wu F, Hua Y, Wei Y, Cao Y
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120384
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120384
Identification and characterization of a potent peptide inhibitor targeting FOXM1 in cancer therapy.
Liang A, Chang M, Shang Z, Wang S, Huai R, Hua X, Wu D, Xiang K, Qi S, Jia S, Qi H, Jiang Y, Liu X, Mao C
Biochemical pharmacology 2025 Oct;240:117064
Biochemical pharmacology 2025 Oct;240:117064
Effect of rumen-protected guanidinoacetic acid provision as a dietary supplement on the growth, slaughter performance, and meat quality in simmental bulls.
Zhang J, Xue C, Lang J, Pei C, Liu Q
Meat science 2025 Oct;228:109889
Meat science 2025 Oct;228:109889
Lithium Exposure Causes Trophoblast Cuproptosis by Upregulating FOXO1/STEAP4 Axis in Unexplained Miscarriage.
Xing S, Lin Y, Sun Y, Yue X, Fan Q, Nie J, Zhang Z, Liu Y, Yang J, Kang Q, Wang Y, Yan H, Tian C, Chang Y, Zhang H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e02139
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e02139
Lipidomics Revealed the Suppression of 5-PAHSA from Human Milk on Macrophage Foam Cell Formation.
Zhang Y, Zhu S, He Y, Lei JN, Wang H, Tan C, Liu YF, Chen M, Xu YJ
Journal of agricultural and food chemistry 2025 Oct 22;73(42):27089-27098
Journal of agricultural and food chemistry 2025 Oct 22;73(42):27089-27098
O-GlcNAc transferase influences the progression of degenerative cartilage disease in lumbar facet joint osteoarthritis through FoxO1 and EGR1.
Chen C, Gao Y, Xu G, Sun Y, Bao G, Liu W, Xu D, Yuan K, Cui Z
Cell death discovery 2025 Oct 16;11(1):462
Cell death discovery 2025 Oct 16;11(1):462
Nicotinamide mononucleotide rescues Di-n-butyl phthalate induced blood-brain barrier damage via NAD(+)/Sirt1/FOXO1a pathway activation.
Liu R, Feng J, Song Y, Yin H, Yang Z, Zhao Y, Ma J, Chen X, Gao H
Ecotoxicology and environmental safety 2025 Oct 15;305:119290
Ecotoxicology and environmental safety 2025 Oct 15;305:119290
Circular RNA circDhx32 promotes cardiac inflammatory responses in mouse cardiac ischemia-reperfusion injury via binding to FOXO1 competed with AdipoR1.
Si W, Wang CL, Zeng LH, Zhao QY, Xie YT, Yang Y, Diao HT, Song JL, Wu H, Zhang F, Wang Z, Kong X, Jiang WT, Zhang XY, Lin KY, Yao FT, Xiong YT, Pan TF, Pang P, Yang BF, Bian Y
Acta pharmacologica Sinica 2025 Nov;46(11):2924-2937
Acta pharmacologica Sinica 2025 Nov;46(11):2924-2937
Polystyrene nanoplastics impair endometrial decidualization via cell cycle arrest and JNK-MAPK pathway-mediated oxidative stress in early pregnant mice.
Li JA, Wang LQ, Xu QJ, Wu XM, Pang XQ, He JX, Qiao QF, You HN, Wu YC, Zhou YJ
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Nov;205:115707
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Nov;205:115707
MDMX reprograms glycolysis of hepatocellular carcinoma via 14-3-3γ/FOXO1.
Chen H, Pan Q, Mao M, Lin W, Yan S, Liu J, Lin S, Li Q, Xue S, Xie Y, Ding L, Zheng D, You J, Huang Q
Cell death discovery 2025 Nov 7;11(1):509
Cell death discovery 2025 Nov 7;11(1):509
Downregulation of PDIA4 inhibits proliferation and migration in human oral squamous cell carcinoma.
Hu Y, Zhang W, Zhang F, Liu Q, Yang H
Hereditas 2025 Nov 3;162(1):222
Hereditas 2025 Nov 3;162(1):222
FSH-Induced Nuclear Exclusion of FOXO1 Mediated by PI3K/Akt Signaling Pathway in Granulosa Cells Is Associated with Follicle Selection and Growth of the Hen Ovary.
Yan C, Ou Y, Sun X, Sun Y, Zhao J, Qin N, Xu R
Cells 2025 Nov 26;14(23)
Cells 2025 Nov 26;14(23)
Microenvironment-responsive multifunctional enzyme-linked hydrogel for diabetic bone defect regeneration.
Fu X, Luo Z, Guo Y, Meng W, Jin S, Chen J, Cai Y, Luo Z, Huang C, Chen A, Guo S, Chen M, Zhou Z, Zeng W
Nature communications 2025 Nov 21;16(1):10275
Nature communications 2025 Nov 21;16(1):10275
Omentin-1 promotes wound healing in diabetic mice by improving vascular endothelial cell function.
Huang Y, Ding Y, Ma Z, Yang P, Ding X, Yan X
Scientific reports 2025 Nov 20;15(1):40956
Scientific reports 2025 Nov 20;15(1):40956
Associations between FOXO1 expression in tissue, the pathological characteristics of colorectal cancer, and patient survival.
Zhang G, Zhang Z, Zhou Y
International journal of colorectal disease 2025 May 2;40(1):105
International journal of colorectal disease 2025 May 2;40(1):105
Astragaloside IV prevents liver fibrosis by blocking glycolysis-mediated macrophage M1 polarization.
Hu Y, Kuang M, Song H, Tan Y, Zhou F, Pei G, Jiao L
European journal of pharmacology 2025 May 15;995:177353
European journal of pharmacology 2025 May 15;995:177353
Endoplasmic reticulum stress and forkhead box protein O1 inhibition mediate palmitic acid and high glucose-induced β-cell dedifferentiation.
Wang LK, Kong CC, Yu TY, Sun HS, Yang L, Sun Y, Li MY, Wang W
World journal of diabetes 2025 May 15;16(5):95431
World journal of diabetes 2025 May 15;16(5):95431
Psychological stress-induced systemic corticosterone directly sabotages intestinal stem cells and exacerbates colitis.
Sheng X, Jin L, Yao Z, Gu J, Zhu L, Huang A, Peng J, Xu X, Ge X, Zhou W, Sheng J, Xu Z, Bai R
Cell discovery 2025 May 13;11(1):46
Cell discovery 2025 May 13;11(1):46
miR-138-5p inhibits healing of femoral fracture osteogenesis in rats by modulating osteoblast differentiation via SIRT1/FOXO1 axis.
Dai G, Jiang W, Feng B, Zhang L
Journal of orthopaedic surgery and research 2025 Mar 14;20(1):280
Journal of orthopaedic surgery and research 2025 Mar 14;20(1):280
Harnessing engineered exosomes as METTL3 carriers: Enhancing osteogenesis and suppressing lipogenesis in bone marrow mesenchymal stem cells for postmenopausal osteoporosis treatment.
Li T, Zhao J, Yuan J, Ding R, Yang G, Cao J, Zhao X, Liu J, Liu Y, Xu P, Deng J, Miao X, Cheng X
Materials today. Bio 2025 Jun;32:101648
Materials today. Bio 2025 Jun;32:101648
Ginsenoside Rk1 Ameliorates Non-Alcoholic Fatty Liver Disease by Targeting CD36 to Modulate the AMPK Signaling Pathway.
Wu Y, Duan Z, Qu L, Liu Y, Ma X, Fan D
Food research international (Ottawa, Ont.) 2025 Jun;211:116426
Food research international (Ottawa, Ont.) 2025 Jun;211:116426
Luteolin Potentially Alleviates Methamphetamine Withdrawal-Induced Negative Emotions and Cognitive Deficits Through the AKT/FOXO1/HO-1 Signaling Pathway in the Prefrontal Cortex and Caudate Putamen.
Gao B, An R, Liang M, Wang X, Peng J, Chen X, Liu Z, Li T, Liu X, Zhang J, Han W
International journal of molecular sciences 2025 Jun 15;26(12)
International journal of molecular sciences 2025 Jun 15;26(12)
FOXO1 contributes to cigarette smoke condensate-induced cellular senescence and fibrosis in lung fibroblasts through activating the TGF-β1/Smad2/3 signaling pathway.
Zheng M, Yuan G, Han J, Li J, Jiang Y, Li Z, Yao Y
Immunologic research 2025 Jun 11;73(1):94
Immunologic research 2025 Jun 11;73(1):94
Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy.
Xiang W, Zhang T, Li B, Li S, Zhang B, Fang S, Chen L, Gong Y, Huang B, Feng D, Wu J, Yuan J, Wu Y, Yan X, Jin R, Zhang X, Fang X, Lian J, Chen L, Zhou S, Ni Z
Nature aging 2025 Jul;5(7):1295-1316
Nature aging 2025 Jul;5(7):1295-1316
MET promotes hepatocellular carcinoma development through the promotion of TRIB3-mediated FOXO1 degradation.
Wang T, Rao D, Fu C, Sun Z, Luo Y, Lu J, Jin J, Li H, Fan F, Liang H, Huang W, Xia L
Clinical and molecular hepatology 2025 Jul;31(3):1032-1057
Clinical and molecular hepatology 2025 Jul;31(3):1032-1057
Rosmarinic Acid Ameliorates Type 2 Diabetic Osteoporosis by Reducing NLRP3 Expression and Alleviating Osteoblast Pyroptosis via the FOXO1/TXNIP Signaling Pathway.
Feng S, Ma R, Huang Y, Pan L, Guo Y, Wang Y, Chen Z, Li E, Bu Y, Luo J, Tang J, Yang L
Journal of agricultural and food chemistry 2025 Jul 2;73(26):16557-16572
Journal of agricultural and food chemistry 2025 Jul 2;73(26):16557-16572
Kushenol I combats ulcerative colitis via intestinal barrier preservation and gut microbiota optimization.
He XD, Li M, Zuo XD, Ni HY, Han YX, Hu YK, Yu J, Yang XX
World journal of gastroenterology 2025 Jul 14;31(26):105656
World journal of gastroenterology 2025 Jul 14;31(26):105656
Rspo3-mediated metabolic liver zonation regulates systemic glucose metabolism and body mass in mice.
Uno K, Uchino T, Suzuki T, Sayama Y, Edo N, Uno-Eder K, Morita K, Ishikawa T, Koizumi M, Honda H, Katagiri H, Tsukamoto K
PLoS biology 2025 Jan;23(1):e3002955
PLoS biology 2025 Jan;23(1):e3002955
Aberrant TCF21 upregulation in adenomyosis impairs endometrial decidualization by increasing PDE4C expression.
Yu R, Wei C, Li G, Ouyang J, Liu N, Gu N, Lin Y, Xu H
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167526
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167526
Network pharmacology, transcriptomics, and biological validation reveal a lipid secretion inhibitory and anti-inflammatory mechanism of tanreqing gel in the treatment of acne.
Ren X, Zhou N, Li D, Li L, Wang Y, Li L, Ma Y, Gao X, Zhao Y, Sun Y, Wang Y
Journal of ethnopharmacology 2025 Jan 31;340:119278
Journal of ethnopharmacology 2025 Jan 31;340:119278
HouShiHeiSan attenuates sarcopenia in middle cerebral artery occlusion (MCAO) rats.
Qi H, Gao Y, Zhang Z, Zhang X, Tian D, Jiang Y, Zhang L, Zeng N, Yang R
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118917
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118917
SIRT6 knockdown alleviates keratinocyte hyperproliferation and inflammation in psoriasis via modulating acetylation of FOXO1.
Cheng C, Wang Y, Huo J, Zhang Y, Li R
International immunopharmacology 2025 Jan 27;146:113932
International immunopharmacology 2025 Jan 27;146:113932
YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies.
Chen Z, Zeng C, Yang L, Che Y, Chen M, Sau L, Wang B, Zhou K, Chen Y, Qing Y, Shen C, Zhang T, Wunderlich M, Wu D, Li W, Wang K, Leung K, Sun M, Tang T, He X, Zhang L, Swaminathan S, Mulloy JC, Müschen M, Huang H, Weng H, Xiao G, Deng X, Chen J
Cell 2025 Jan 23;188(2):331-351.e30
Cell 2025 Jan 23;188(2):331-351.e30
Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice.
Sun S, Yu T, Huh JY, Cai Y, Yoon S, Javaid HMA
Skeletal muscle 2025 Jan 13;15(1):2
Skeletal muscle 2025 Jan 13;15(1):2
Developmental exposure to perfluorooctane sulfonate(PFOS) impairs the endometrial receptivity.
Ren R, Zhou X, Jia T, Wang B, Liu A, Gao M, Song J, Wang L, Jing Y, Yu L, Shen H, Zhang X
Scientific reports 2025 Jan 11;15(1):1747
Scientific reports 2025 Jan 11;15(1):1747
NCAPD3-mediated AKT activation regulates prostate cancer progression.
Zhang Y, Xie W, Zong X, Fang Y, Ren J, Jing Z, Wei Y, Lu S, Zhu Q, Liu P
FASEB bioAdvances 2025 Feb;7(2):e1488
FASEB bioAdvances 2025 Feb;7(2):e1488
Proline exacerbates hepatic gluconeogenesis via paraspeckle-dependent mRNA retention.
Zhao Y, Chai X, Peng J, Zhu Y, Dong R, He J, Xia L, Liu S, Chen J, Xu Z, Luo C, Sheng J
Nature metabolism 2025 Feb;7(2):367-382
Nature metabolism 2025 Feb;7(2):367-382
Doxorubicin-loaded PEGylated liposome modified with ANGPT2-specific peptide for integrative glioma-targeted imaging and therapy.
Li H, Gan R, Liu J, Xu D, Zhang Q, Tian H, Guo H, Wang H, Wang Z, Zeng X
Materials today. Bio 2025 Feb;30:101455
Materials today. Bio 2025 Feb;30:101455
Semaglutide Mitigates Ischemic Brain Injury by Inhibiting Ferroptosis via Modulation of FoXO1 and DRP1 Pathways.
Wang W, Pang M, Zhang Y, Hou S, Xia Y, Shi Y, Zhang X, Wang Y
Molecular neurobiology 2025 Dec;62(12):16168-16188
Molecular neurobiology 2025 Dec;62(12):16168-16188
Enhanced FOXO1 expression as a predictor of decitabine response and prolonged survival in high-risk myelodysplastic syndrome.
Liu H, Zhang Z, Huang N, Xu F, Zhao S, Chang C
Hematology (Amsterdam, Netherlands) 2025 Dec;30(1):2506862
Hematology (Amsterdam, Netherlands) 2025 Dec;30(1):2506862
Tauroursodeoxycholic acid ameliorates palmitic acid induced endoplasmic reticulum stress and impaired autophagy via IRE1- XBP1-FoxO1 pathway in KGN cells.
Cao M, Qiao F, Wang Q, Luo J, Ju Y, Wang X, Chen X
Biochemical pharmacology 2025 Dec;242(Pt 4):117377
Biochemical pharmacology 2025 Dec;242(Pt 4):117377
Fast Myosin Binding Protein-C Is a Vital Regulator in Young and Aged Fast Skeletal Muscle Homeostasis.
Baby A, Ananthamohan K, McIntyre BN, Natesan S, Song T
Journal of cachexia, sarcopenia and muscle 2025 Dec;16(6):e70106
Journal of cachexia, sarcopenia and muscle 2025 Dec;16(6):e70106
Targeting FoxO1-STX17-mediated autophagic flux: Quercetin's therapeutic mechanism in diabetic nephropathy.
Hou B, Li Y, Tang J, Cao X, Zhang S, Cai Y, Guo J, Xi J, Wang D, Liu WJ, Lu H
European journal of pharmacology 2025 Dec 5;1008:178309
European journal of pharmacology 2025 Dec 5;1008:178309
FTO-mediated m6A modification regulates the osteogenic differentiation of ADSCs by targeting FOXO1.
Wang Z, Wen S, Li H, Wang X, Guo S, Yang S
Stem cell research & therapy 2025 Dec 17;17(1):39
Stem cell research & therapy 2025 Dec 17;17(1):39
Hepatic metabolic reprogramming in male mice during short-term caloric restriction involves enhanced glucocorticoid rhythms.
Makris K, Fonda V, Ramadhani FF, Fadel L, Davezac M, Payet B, Deligiannis IK, Zhang L, Horn T, Heimerl L, Jouffe C, Heddes M, Martinez-Jimenez CP, Quagliarini F, Uhlenhaut NH
Nature communications 2025 Dec 11;16(1):11106
Nature communications 2025 Dec 11;16(1):11106
Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1.
Kuang B, Geng N, Yi M, Zeng Q, Fan M, Xian M, Deng L, Chen C, Pan Y, Kuang L, Luo F, Xie Y, Liu C, Deng Z, Nie M, Du Y, Guo F
Journal of advanced research 2025 Aug;74:493-511
Journal of advanced research 2025 Aug;74:493-511
EGCG and Taurine Synergistically Ameliorate Lipid Metabolism Disorder by Modulating Gut Microbiota and PPARα/FAS Signaling Pathway.
Xiao Y, Yang M, Cai M, Zhang H, Hu K, Duan Y
Nutrients 2025 Aug 9;17(16)
Nutrients 2025 Aug 9;17(16)
Galectin-3-integrin α5β1 phase separation disrupted by advanced glycation end-products impairs diabetic wound healing in rodents.
Zhang Z, Zhao Z, Huang X, Zhou L, Jiang X, Wu H, Liu C, Huang K, Wen J, Liu Y, Miller MC, Zhao Z, He Z, Wang Y, Liu S, Huang L, Yuan L, Zeng R, Cen Z, Chen A, Chen Y, Zeng G, Liu W, Hong X, Ren M, Yan L, Zhang Y, Guan D, Tian X, Cai W, Tai G, Mayo KH, Zhou Y, Li Z, Chen S
Nature communications 2025 Aug 7;16(1):7287
Nature communications 2025 Aug 7;16(1):7287
Mild hypothermia attenuates hepatic ischemia-reperfusion injury by regulating FoxO1/PPARα pathway.
Lu Z, Chen H, Liu A, Na S, Wang W, Zhong Z, Ye Q
Scientific reports 2025 Aug 6;15(1):28800
Scientific reports 2025 Aug 6;15(1):28800
Oxaloacetate promotes the transition from glycolysis to gluconeogenesis through the Akt-FoxO1 and JNK/c-Jun-FoxO1 axes and inhibits the survival of liver cancer cells.
Miao Z, Liu Y, Xu Y, Bu J, Yang Q
International immunopharmacology 2025 Aug 28;161:115051
International immunopharmacology 2025 Aug 28;161:115051
The study of JAZF1-mediated apoptosis of decidual stromal cells by activating the NF-κB signaling pathway in spontaneous preterm birth.
Gong MQ, Hu YY, Zhang YQ, Wang XD
BMC pregnancy and childbirth 2025 Aug 27;25(1):891
BMC pregnancy and childbirth 2025 Aug 27;25(1):891
CircRNA (circ)_0007823 Contributes to Triple-Negative Breast Cancer Progression and Cisplatin Resistance via the miR-182-5p/FOXO1 Pathway.
Wang H, Wang X, Shen W, Zhou Y, Cui J, Li H, Yu J
Biochemical genetics 2025 Apr;63(2):1330-1342
Biochemical genetics 2025 Apr;63(2):1330-1342
Upregulation of FAM129B protects against glucocorticoid-induced skeletal muscle atrophy via regulating long non-coding RNA NEAT1.
Wang Y, Lu Y, Hou J, Wang Y, Luo L, Lu Z, Xie Y, Cai L, Xiao Z
International journal of biological macromolecules 2025 Apr;300:140120
International journal of biological macromolecules 2025 Apr;300:140120
Decidual Disrupting Effects of Low-Dose Benzophenone-Type UV Filters in Human Endometrial Stromal Cells via ER/PR/FOXO1 Signaling.
Zhan T, Shen L, Zhang Y, Wan F, Qiu Y, Jin Q, Wu Y, Huang Y, Zhuang S
Environmental science & technology 2025 Apr 8;59(13):6464-6476
Environmental science & technology 2025 Apr 8;59(13):6464-6476
Integrated Network Pharmacology and in vivo Experimental Validation Approach to Explore the Potential Antioxidant Effects of Annao Pingchong Decoction in Intracerebral Hemorrhage Rats.
Zhou X, Wang X, Li J, Zhang M, Yang Y, Lei S, He Y, Yang H, Zhou D, Guo C
Drug design, development and therapy 2024;18:699-717
Drug design, development and therapy 2024;18:699-717
Network Pharmacology-Based Strategy to Explore the Effect and Mechanism of Zhizhu Granule Improving Glucose-Lipid Metabolism in Rats with Metabolic Syndrome.
Wang J, Liu Y, Xiu C, Wang X, Liu Y, Hu Y, Yang J, Lei Y
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:3833-3846
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:3833-3846
THSR Mediated MiR374b Targeting C/EBP β/FOXO1 to Accelerate Thyroid Stimulating Hormone-Induced Hepatic Steatosis.
Li J, Ge Y, Chai Y, Kou C, Sun TT, Liu J, Zhang H
Hepatic medicine : evidence and research 2024;16:91-104
Hepatic medicine : evidence and research 2024;16:91-104
CREG1 attenuates doxorubicin-induced cardiotoxicity by inhibiting the ferroptosis of cardiomyocytes.
Liu D, Cheng X, Wu H, Song H, Bu Y, Wang J, Zhang X, Yan C, Han Y
Redox biology 2024 Sep;75:103293
Redox biology 2024 Sep;75:103293
Gentiopicroside ameliorates glucose and lipid metabolism in T2DM via targeting FGFR1.
Xu Z, Huang J, Wen M, Zhang X, Lyu D, Li S, Xiao H, Li M, Shen C, Huang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155780
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155780
A metabolic atlas of blood cells in young and aged mice identifies uridine as a metabolite to rejuvenate aged hematopoietic stem cells.
Zeng X, Shi C, Han Y, Hu K, Li X, Wei C, Ding L, Cui J, Huang S, Xu Y, Zhang M, Shan W, Luo Q, Yu J, Zheng Z, Li X, Qian P, Huang H
Nature aging 2024 Oct;4(10):1477-1492
Nature aging 2024 Oct;4(10):1477-1492
Neurons enhance blood-brain barrier function via upregulating claudin-5 and VE-cadherin expression due to glial cell line-derived neurotrophic factor secretion.
Yang L, Lin Z, Mu R, Wu W, Zhi H, Liu X, Yang H, Liu L
eLife 2024 Oct 30;13
eLife 2024 Oct 30;13
CircGNAO1 suppresses hepatocellular carcinoma progression and metastasis via sponging miR-182-5p and regulating FOXO1 expression.
Ju L, Luo Y, Shan J, Lu R, Chen L, Shao J, Bian Z, Yao M
International immunopharmacology 2024 Oct 25;140:112873
International immunopharmacology 2024 Oct 25;140:112873
Bifidobacterium lactis-Derived Vesicles Attenuate Hippocampal Neuroinflammation by Targeting IL-33 to Regulate FoxO6/P53 Signaling.
Du X, Zhang M, Wang R, Zeng Z, Zhao W, Fang B, Lan H, Hung W, Gao H
Nutrients 2024 Oct 22;16(21)
Nutrients 2024 Oct 22;16(21)
FOXO1-mTOR pathway in vascular pericyte regulates the formation of type H vessels to control bone metabolism.
Cheng C, Deng M, Cheng C, Wu H, Wang Y, Lu M, Yao Z, Li K, Zhang X, Yu B
Journal of orthopaedic translation 2024 Nov;49:246-263
Journal of orthopaedic translation 2024 Nov;49:246-263
PXD101 inhibits malignant progression and radioresistance of glioblastoma by upregulating GADD45A.
Hu X, Zhou P, Peng X, Ouyang Y, Li D, Wu X, Yang L
Journal of translational medicine 2024 Nov 20;22(1):1047
Journal of translational medicine 2024 Nov 20;22(1):1047
Acetylation of FOXO1 is involved in cadmium-induced rat kidney injury via mediating autophagosome-lysosome fusion blockade and autophagy inhibition.
Ruan Y, Xue Y, Zhang P, Jia J
Ecotoxicology and environmental safety 2024 Nov 15;287:117253
Ecotoxicology and environmental safety 2024 Nov 15;287:117253
The P300-ARRDC3 axis participates in maternal subclinical hypothyroidism and is involved in abnormal hepatic insulin sensitivity in adult offspring.
Huo M, Yu X, Yuan X, Guo J, Wei B, Shi Y, Gu Y, Zhang X, Sun M
Heliyon 2024 Nov 15;10(21):e39259
Heliyon 2024 Nov 15;10(21):e39259
Sorcin promotes proliferation of hepatocellular carcinoma by regulating VEGFA/B via PI3K pathway.
Zhang H, Hu S, Sanches JGP, Li Y, Wei Y, Pu C, Zhang J
Journal of physiology and biochemistry 2024 May;80(2):381-392
Journal of physiology and biochemistry 2024 May;80(2):381-392
Eicosapentaenoic acid-mediated activation of PGAM2 regulates skeletal muscle growth and development via the PI3K/AKT pathway.
Li C, Cao H, Ren Y, Jia J, Yang G, Jin J, Shi X
International journal of biological macromolecules 2024 May;268(Pt 2):131547
International journal of biological macromolecules 2024 May;268(Pt 2):131547
Lycopene Promotes Osteogenesis and Reduces Adipogenesis through Regulating FoxO1/PPARγ Signaling in Ovariectomized Rats and Bone Marrow Mesenchymal Stem Cells.
Xia B, Dai X, Shi H, Yin J, Xu T, Liu T, Yue G, Guo H, Liang R, Liu Y, Gao J, Wang X, Chen X, Tang J, Wang L, Zhu R, Zhang D
Nutrients 2024 May 10;16(10)
Nutrients 2024 May 10;16(10)
Lipoteichoic acid restrains macrophage senescence via β-catenin/FOXO1/REDD1 pathway in age-related osteoporosis.
Cheng W, Fu Y, Lin Z, Huang M, Chen Y, Hu Y, Lin Q, Yu B, Liu G
Aging cell 2024 Mar;23(3):e14072
Aging cell 2024 Mar;23(3):e14072
Linoleic acid induces human ovarian granulosa cell inflammation and apoptosis through the ER-FOXO1-ROS-NFκB pathway.
Zhang W, Wu F
Scientific reports 2024 Mar 16;14(1):6392
Scientific reports 2024 Mar 16;14(1):6392
Echinacoside alleviates glucocorticoid induce osteonecrosis of femoral head in rats through PI3K/AKT/FOXO1 pathway.
Huang LK, Zeng XS, Jiang ZW, Peng H, Sun F
Chemico-biological interactions 2024 Mar 1;391:110893
Chemico-biological interactions 2024 Mar 1;391:110893
Elucidation of the anti-β-cell dedifferentiation mechanism of a modified Da Chaihu Decoction by an integrative approach of network pharmacology and experimental verification.
Chen H, Guo J, Cai Y, Zhang C, Wei F, Sun H, Cheng C, Liu W, He Z
Journal of ethnopharmacology 2024 Mar 1;321:117481
Journal of ethnopharmacology 2024 Mar 1;321:117481
Long-chain acyl-CoA synthetase-4 regulates endometrial decidualization through a fatty acid β-oxidation pathway rather than lipid droplet accumulation.
Zhang H, Sun Q, Dong H, Jin Z, Li M, Jin S, Zeng X, Fan J, Kong Y
Molecular metabolism 2024 Jun;84:101953
Molecular metabolism 2024 Jun;84:101953
CAPN2 promotes apalutamide resistance in metastatic hormone-sensitive prostate cancer by activating protective autophagy.
Qi Z, Bai X, Wu L, Zhang P, Guo Z, Yu Y
Journal of translational medicine 2024 Jun 6;22(1):538
Journal of translational medicine 2024 Jun 6;22(1):538
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK.
Li Y, Munoz-Mayorga D, Nie Y, Kang N, Tao Y, Lagerwall J, Pernaci C, Curtin G, Coufal NG, Mertens J, Shi L, Chen X
Cell metabolism 2024 Jun 4;36(6):1351-1370.e8
Cell metabolism 2024 Jun 4;36(6):1351-1370.e8
GSK2334470 attenuates high salt-exacerbated rheumatoid arthritis progression by restoring Th17/Treg homeostasis.
Mo Q, Bolideei M, Rong SJ, Luo JH, Yang CL, Lu WY, Chen QJ, Zhao JW, Wang FX, Wang T, Li Y, Luo X, Zhang S, Xiong F, Yu QL, Zhang ZY, Liu SW, Sun F, Dong LL, Wang CY
iScience 2024 Jun 21;27(6):109798
iScience 2024 Jun 21;27(6):109798
Overexpression of FHL1 suppresses papillary thyroid cancer proliferation and progression via inhibiting Wnt/β-catenin pathway.
Chen J, Zeng C, Jin J, Zhang P, Zhang Y, Zhang H, Li Y, Guan H
Endocrine 2024 Jul;85(1):238-249
Endocrine 2024 Jul;85(1):238-249
DDX20 is required for cell-cycle reentry of prospermatogonia and establishment of spermatogonial stem cell pool during testicular development in mice.
Zou D, Li K, Su L, Liu J, Lu Y, Huang R, Li M, Mang X, Geng Q, Li P, Tang J, Yu Z, Zhang Z, Chen D, Miao S, Yu J, Yan W, Song W
Developmental cell 2024 Jul 8;59(13):1707-1723.e8
Developmental cell 2024 Jul 8;59(13):1707-1723.e8
The protective effects of aqueous extract of Schisandra sphenanthera against alcoholic liver disease partly through the PI3K-AKT-IKK signaling pathway.
Liu D, Yang K, Li T, Tang T, Wang Y, Wang W, Li J, Zhou P, Wang X, Zhao C, Guo D, Xie Y, Cheng J, Wang M, Sun J, Zhang X
Heliyon 2024 Jul 15;10(13):e34214
Heliyon 2024 Jul 15;10(13):e34214
Microglial FoxO3a deficiency ameliorates ferroptosis-induced brain injury of intracerebral haemorrhage via regulating autophagy and heme oxygenase-1.
Wang R, Liang Z, Xue X, Mei H, Ji L, Wang B, Chen W, Gao C, Yuan S, Wu T, Qi H, Hu S, Yi L, Song Y, Liao R, Chen B
Journal of cellular and molecular medicine 2024 Jan;28(1):e18007
Journal of cellular and molecular medicine 2024 Jan;28(1):e18007
Decreased FoxO1 expression contributes to facet joint osteoarthritis pathogenesis by impairing chondrocyte migration and extracellular matrix synthesis.
Chen C, Xu G, Chen J, Wu C, Zhang J, Jiang J, Hong H, Cui Z
Cellular signalling 2024 Jan;113:110942
Cellular signalling 2024 Jan;113:110942
EGF-driven EGFR/miR-27b-3p/FOXO1 promotes rat FSH synthesis and secretion.
Ma YR, Gao W, Wang HQ, Zhao PS, Zhang YX, Wei FH, Jiang H, Zhang JB, Yuan B, Gao F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Feb 29;38(4):e23469
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Feb 29;38(4):e23469
Txnip promotes autophagic apoptosis in diabetic cardiomyopathy by upregulating FoxO1 and its acetylation.
Zhang Y, Li B, Fu Y, Cai H, Zheng Y
Cellular signalling 2024 Dec;124:111469
Cellular signalling 2024 Dec;124:111469
Ginkgolide A enhances FoxO1 expression and reduces endoplasmic reticulum stress to mitigate osteoarthritis in mice.
Yu H, Liang J, Bao Y, Chen K, Jin Y, Li X, Chen H, Gou Y, Lu K, Lin Z
International immunopharmacology 2024 Dec 5;142(Pt B):113116
International immunopharmacology 2024 Dec 5;142(Pt B):113116
Oligomeric Proanthocyanidins Ameliorate Cadmium-Induced Senescence of Osteocytes Through Combating Oxidative Stress and Inflammation.
Yu G, Wang Z, Gong A, Fu X, Chen N, Zhou D, Li Y, Liu Z, Tong X
Antioxidants (Basel, Switzerland) 2024 Dec 12;13(12)
Antioxidants (Basel, Switzerland) 2024 Dec 12;13(12)
Sleep deprivation induced fat accumulation in the visceral white adipose tissue by suppressing SIRT1/FOXO1/ATGL pathway activation.
Wang W, Liu K, Xu H, Zhang C, Zhang Y, Ding M, Xing C, Huang X, Wen Q, Lu C, Song L
Journal of physiology and biochemistry 2024 Aug;80(3):561-572
Journal of physiology and biochemistry 2024 Aug;80(3):561-572
Osthole exhibits the remedial potential for polycystic ovary syndrome mice through Nrf2-Foxo1-GSH-NF-κB pathway.
Jin S, Wang YS, Huang JC, Wang TT, Li BY, Guo B, Yue ZP
Cell biology international 2024 Aug;48(8):1111-1123
Cell biology international 2024 Aug;48(8):1111-1123
The FOXO1/G6PC axis promotes gastric cancer progression and mediates 5-fluorouracil resistance by targeting the PI3K/AKT/mTOR signaling pathway.
Han A, Liu T, Du P, Wang M, Liu J, Chen L
Molecular carcinogenesis 2024 Apr;63(4):688-700
Molecular carcinogenesis 2024 Apr;63(4):688-700
Baicalin Maintains Articular Cartilage Homeostasis and Alleviates Osteoarthritis by Activating FOXO1.
Wei Q, Yu Z, Yang P, Chen X
Journal of medicinal food 2024 Apr;27(4):301-311
Journal of medicinal food 2024 Apr;27(4):301-311
Phytic acid promotes high glucose-mediated bone marrow mesenchymal stem cells osteogenesis via modulating circEIF4B that sponges miR-186-5p and complexes with IGF2BP3.
Wu J, Li X, Nie H, Shen Y, Guo Z, Huihan Chu C, Cai K, Tang C
Biochemical pharmacology 2024 Apr;222:116118
Biochemical pharmacology 2024 Apr;222:116118
Resistance exercise preconditioning prevents disuse muscle atrophy by inhibiting apoptosis and protein degradation via SESN2 in C57BL/6J mice.
Huang Y, Jiang C, Li X, Liu S, Niu Y, Fu L
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167111
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167111
Effect of beta-cypermethrin on the reproductive capacity of female mice in advanced age.
Qiao QF, Wang LQ, Yu DE, Li N, Xu QJ, Zhou YJ
Environmental toxicology and pharmacology 2024 Apr;107:104410
Environmental toxicology and pharmacology 2024 Apr;107:104410
Diterpenoid tanshinones inhibit gastric cancer angiogenesis through the PI3K/Akt/mTOR signaling pathway.
Yu JR, Liu YY, Gao YY, Qian LH, Qiu JL, Wang PP, Zhang GJ
Journal of ethnopharmacology 2024 Apr 24;324:117791
Journal of ethnopharmacology 2024 Apr 24;324:117791
Angiotensin (1-7) reverses glucose-induced islet β cell dedifferentiation by Wnt/β-catenin/FoxO1 signalling pathway.
Guo D, He J, Guo H, Song G, Peng L, An M, Wang C
Endokrynologia Polska 2023;74(5):544-552
Endokrynologia Polska 2023;74(5):544-552
Study on the Mechanism of Jiaotai Pill Intervention on Insomnia Animal Model Based on Gut Microbiome and Metabolomics.
Yang Y, Liu J, Ou H, Ma X, Li J, Shao B, Jin R, Zhao J
Evidence-based complementary and alternative medicine : eCAM 2023;2023:2442505
Evidence-based complementary and alternative medicine : eCAM 2023;2023:2442505
Hsa_circ_0007823 Overexpression Suppresses the Progression of Triple-Negative Breast Cancer via Regulating miR-182-5p-FOXO1 Axis.
Yu J, Wang H, Shen W, Zhou Y, Cui J, Li H, Gao B
Breast cancer (Dove Medical Press) 2023;15:695-708
Breast cancer (Dove Medical Press) 2023;15:695-708
The downstream network of STAT6 in promoting vascular smooth muscle cell phenotypic switch and neointimal formation.
Ding S, Wang X, Wang Y, Zhang Z, Yang X, Zhu X, Zhu B, Xiao C, Ge J, Yang X
Cell biology international 2023 Sep;47(9):1573-1588
Cell biology international 2023 Sep;47(9):1573-1588
Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis.
Cui Y, Zhang W, Yang P, Zhu S, Luo S, Li M
Free radical biology & medicine 2023 Sep;206:33-49
Free radical biology & medicine 2023 Sep;206:33-49
FoxO1 is a negative regulator of neointimal hyperplasia in a rat model of patch angioplasty.
Sun P, Cui H, Wang S, Zhang Y, Hong S, Wang X, Ren C, Lai Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115262
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115262
miR-552 promotes the proliferation and metastasis of intrahepatic cholangiocarcinoma by targeting FOXO1.
Cheng Z, Cheng N, Tang X, Yang F, Ma W, Yu Q, Tang H, Xiao Q, Lei Z
Experimental cell research 2023 Oct 1;431(1):113741
Experimental cell research 2023 Oct 1;431(1):113741
Role of SIRT2 in intestinal barrier under cold exposure.
Guo J, Xu J, Chen L, Chen Z, Hu H, Nie J, Yuan J, Ma L, Lu J, Ji H, Xu B
Life sciences 2023 Oct 1;330:121949
Life sciences 2023 Oct 1;330:121949
MiR-337-3p improves metabolic-associated fatty liver disease through regulation of glycolipid metabolism.
Xu X, Yu C, He H, Pan X, Hou A, Feng J, Tan R, Gong L, Chen J, Ren J
iScience 2023 Nov 17;26(11):108352
iScience 2023 Nov 17;26(11):108352
Hexavalent chromium caused DNA damage repair and apoptosis via the PI3K/AKT/FOXO1 pathway triggered by oxidative stress in the lung of rat.
Zhang L, Li N, Zhang X, Wu H, Yu S
Ecotoxicology and environmental safety 2023 Nov 15;267:115622
Ecotoxicology and environmental safety 2023 Nov 15;267:115622
Douchi Peptides VY and SFLLR Improve Glucose Homeostasis and Gut Dysbacteriosis in High-Fat Diet-Induced Insulin Resistant Mice.
Yu S, Wang W, Wang H, Bu T, Liu L, Zhao R, Li S, Liu D, Wu J
Molecular nutrition & food research 2023 May;67(10):e2200681
Molecular nutrition & food research 2023 May;67(10):e2200681
The therapeutic mechanism of Yuye decoction on type 2 diabetes mellitus based on network pharmacology and experimental verification.
Guo F, Yao L, Zhang W, Chen P, Hao R, Huang X, Jiang J, Wu S
Journal of ethnopharmacology 2023 May 23;308:116222
Journal of ethnopharmacology 2023 May 23;308:116222
Toxicity mechanism of peri-implantation pesticide beta-cypermethrin exposure on endometrial remodeling in early pregnant mice.
Zhou YJ, Qiao QF, Wang LQ, Sheng TY, Cui MX, Chen QD, Wang CY, Zhang YX
Toxicology 2023 May 1;489:153497
Toxicology 2023 May 1;489:153497
Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila.
Guo S, Zhang S, Zhuang Y, Xie F, Wang R, Kong X, Zhang Q, Feng Y, Gao H, Kong X, Liu T
Proceedings of the National Academy of Sciences of the United States of America 2023 Mar 28;120(13):e2213857120
Proceedings of the National Academy of Sciences of the United States of America 2023 Mar 28;120(13):e2213857120
miR-484 mediates oxidative stress-induced ovarian dysfunction and promotes granulosa cell apoptosis via SESN2 downregulation.
Wang X, Yang J, Li H, Mu H, Zeng L, Cai S, Su P, Li H, Zhang L, Xiang W
Redox biology 2023 Jun;62:102684
Redox biology 2023 Jun;62:102684
Neuro death through autophagy via the acetylation of FoxO1 by SIRT2 in the hippocampus of mice in a autism spectrum disorder mice model.
Guo L, Jiang ZM, Zhan YJ, Pan W, Wu QW, Song FX, Zhou X, Zhou XY, Liu LJ, Wang JT
Journal of cellular physiology 2023 Jun;238(6):1275-1287
Journal of cellular physiology 2023 Jun;238(6):1275-1287
"Biqi" Bayberry Extract Promotes Skeletal Muscle Fiber Type Remodeling by Increasing Fast Myofiber Formation via the Akt/FoxO1 Pathway in Mice.
Li J, Li Y, Suo X, Li J, Huang D, Kou G
Foods (Basel, Switzerland) 2023 Jun 23;12(13)
Foods (Basel, Switzerland) 2023 Jun 23;12(13)
Exercise mitigates Dapagliflozin-induced skeletal muscle atrophy in STZ-induced diabetic rats.
Yang X, Wang L, Zhang L, Zhai X, Sheng X, Quan H, Lin H
Diabetology & metabolic syndrome 2023 Jul 12;15(1):154
Diabetology & metabolic syndrome 2023 Jul 12;15(1):154
The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region.
Fan G, Wang F, Chen Y, Zheng Q, Xiong J, Lv Q, Wu K, Xiong J, Wei L, Li D, Zhang J, Zhang W, Li F
Cell reports 2023 Jan 31;42(1):111916
Cell reports 2023 Jan 31;42(1):111916
PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A-producing γδ T cells.
Edwards SC, Hedley A, Hoevenaar WHM, Wiesheu R, Glauner T, Kilbey A, Shaw R, Boufea K, Batada N, Hatano S, Yoshikai Y, Blyth K, Miller C, Kirschner K, Coffelt SB
The Journal of experimental medicine 2023 Feb 6;220(2)
The Journal of experimental medicine 2023 Feb 6;220(2)
Toxicity assessment of organophosphate flame retardant triphenyl phosphate (TPHP) on intestines in mice.
Peng C, Zhang X, Chen Y, Wang L
Ecotoxicology and environmental safety 2023 Dec;268:115685
Ecotoxicology and environmental safety 2023 Dec;268:115685
[m(6)A methylase WTAP participates in renal ischemia-reperfusion injury by regulating FOXO1 expression].
Zhao G, Li H, Zhang H, Xiao K, Yang H, Li Z, Fu C
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Dec 20;43(12):2035-2042
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Dec 20;43(12):2035-2042
Methionine supplementation spares body protein by regulating the expression of mTORC1 downstream factors in rats fed a soy protein diet with sufficient sulfur amino acids: a pilot study.
Yamada F, Mori E, Yamaoka I
Amino acids 2023 Aug;55(8):1039-1048
Amino acids 2023 Aug;55(8):1039-1048
Ginkgolide A targets forkhead box O1 to protect against lipopolysaccharide-induced septic cardiomyopathy.
Wang L, Zhao Y, Su Z, Zhao K, Li P, Xu T
Phytotherapy research : PTR 2023 Aug;37(8):3309-3322
Phytotherapy research : PTR 2023 Aug;37(8):3309-3322
Targeted long-term noninvasive treatment of choroidal neovascularization by biodegradable nanoparticles.
Yao H, Xu H, Wu M, Lei W, Li L, Liu D, Wang Z, Ran H, Ma H, Zhou X
Acta biomaterialia 2023 Aug;166:536-551
Acta biomaterialia 2023 Aug;166:536-551
The 15-hydroxyprostaglandin dehydrogenase inhibitor SW033291 ameliorates abnormal hepatic glucose metabolism through PGE(2)-EP4 receptor-AKT signaling in a type 2 diabetes mellitus mouse model.
Liang M, Wang L, Wang W
Cellular signalling 2023 Aug;108:110707
Cellular signalling 2023 Aug;108:110707
Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function.
Liao W, Foo HYC, Tran TNQ, Chai CLL, Wong WSF
British journal of pharmacology 2023 Apr;180(8):1056-1071
British journal of pharmacology 2023 Apr;180(8):1056-1071
Ursolic Acid Alleviates Cancer Cachexia and Prevents Muscle Wasting via Activating SIRT1.
Tao W, Ouyang Z, Liao Z, Li L, Zhang Y, Gao J, Ma L, Yu S
Cancers 2023 Apr 20;15(8)
Cancers 2023 Apr 20;15(8)
Silencing CAMK2D Promotes the Proliferation of Spermatogonia in the Testis of Experimental Varicocele Rats.
Tang S, Yang P, Ding Y, Chen Q, Huang H, Chen X, Zhou H
Evidence-based complementary and alternative medicine : eCAM 2022;2022:7121245
Evidence-based complementary and alternative medicine : eCAM 2022;2022:7121245
Lignans from Mosla scabra Ameliorated Influenza A Virus-Induced Pneumonia via Inhibiting Macrophage Activation.
Cai W, Wu LR, Zhang SL
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1688826
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1688826
HB-EGF induces mitochondrial dysfunction via estrogen hypersecretion in granulosa cells dependent on cAMP-PKA-JNK/ERK-Ca(2+)-FOXO1 pathway.
Huang JC, Duan CC, Jin S, Sheng CB, Wang YS, Yue ZP, Guo B
International journal of biological sciences 2022;18(5):2047-2059
International journal of biological sciences 2022;18(5):2047-2059
Oridonin Delays Aging Through the AKT Signaling Pathway.
An Y, Zhu J, Wang X, Sun X, Luo C, Zhang Y, Ye Y, Li X, Abulizi A, Huang Z, Zhang H, Yang B, Xie Z
Frontiers in pharmacology 2022;13:888247
Frontiers in pharmacology 2022;13:888247
ALG-bFGF Hydrogel Inhibiting Autophagy Contributes to Protection of Blood-Spinal Cord Barrier Integrity via PI3K/Akt/FOXO1/KLF4 Pathway After SCI.
Zhang R, Xie L, Wu F, Xu J, Lu L, Cao L, Li L, Meng W, Zhang H, Shao C, Li X, Chen D
Frontiers in pharmacology 2022;13:828896
Frontiers in pharmacology 2022;13:828896
Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway.
Sun F, Zhou JL, Wei SX, Jiang ZW, Peng H
PeerJ 2022;10:e13319
PeerJ 2022;10:e13319
Feeding desensitizes A1 adenosine receptors in adipose through FOXO1-mediated transcriptional regulation.
Granade ME, Hargett SR, Lank DS, Lemke MC, Luse MA, Isakson BE, Bochkis IM, Linden J, Harris TE
Molecular metabolism 2022 Sep;63:101543
Molecular metabolism 2022 Sep;63:101543
Hepatic p53 is regulated by transcription factor FOXO1 and acutely controls glycogen homeostasis.
Oster M, Galhuber M, Krstic J, Steinhoff JS, Lenihan-Geels G, Wulff S, Kiefer MF, Petricek KM, Wowro SJ, Flores RE, Yang N, Li C, Meng Y, Reinisch I, Sommerfeld M, Weger S, Habisch H, Madl T, Schulz TJ, Prokesch A, Schupp M
The Journal of biological chemistry 2022 Sep;298(9):102287
The Journal of biological chemistry 2022 Sep;298(9):102287
Icaritin inhibits CDK2 expression and activity to interfere with tumor progression.
Zhang C, Wang X, Zhang C
iScience 2022 Sep 16;25(9):104991
iScience 2022 Sep 16;25(9):104991
Cold exposure-induced endoplasmic reticulum stress regulates autophagy through the SIRT2/FoxO1 signaling pathway.
Guo J, Nie J, Chen Z, Wang X, Hu H, Xu J, Lu J, Ma L, Ji H, Yuan J, Xu B
Journal of cellular physiology 2022 Oct;237(10):3960-3970
Journal of cellular physiology 2022 Oct;237(10):3960-3970
Recombinant Humanized IgG1 Antibody Protects against oxLDL-Induced Oxidative Stress and Apoptosis in Human Monocyte/Macrophage THP-1 Cells by Upregulation of MSRA via Sirt1-FOXO1 Axis.
Zhang Q, Li Z, Liu X, Zhao M
International journal of molecular sciences 2022 Oct 3;23(19)
International journal of molecular sciences 2022 Oct 3;23(19)
Spindle and kinetochore-associated complex 3 promotes cell growth via the PI3K/AKT/GSK3β and PI3K/AKT/FOXO1 pathways and is a potential prognostic biomarker for oral squamous cell carcinoma.
Xu H, Chen G, Niu Q, Song K, Feng Z, Han Z
Oral surgery, oral medicine, oral pathology and oral radiology 2022 Nov;134(5):599-614
Oral surgery, oral medicine, oral pathology and oral radiology 2022 Nov;134(5):599-614
O-GlcNAcylation of SIRT1 Protects against Cold Stress-Induced Skeletal Muscle Damage via Amelioration of Mitochondrial Homeostasis.
Cao Y, Zhang M, Li Y, Lu J, Zhou W, Li X, Shi H, Xu B, Li S
International journal of molecular sciences 2022 Nov 22;23(23)
International journal of molecular sciences 2022 Nov 22;23(23)
DEAD-box helicase 56 functions as an oncogene promote cell proliferation and invasion in gastric cancer via the FOXO1/p21 Cip1/c-Myc signaling pathway.
Wang J, Wang Y, Wang J, Zhang S, Yu Z, Zheng K, Fu Z, Wang C, Huang W, Chen J
Bioengineered 2022 May;13(5):13970-13985
Bioengineered 2022 May;13(5):13970-13985
LncRNA SNHG8 sponges miR-449c-5p and regulates the SIRT1/FoxO1 pathway to affect microglia activation and blood-brain barrier permeability in ischemic stroke.
Zhang D, Pan N, Jiang C, Hao M
Journal of leukocyte biology 2022 May;111(5):953-966
Journal of leukocyte biology 2022 May;111(5):953-966
The protective effects of butorphanol tartrate against homocysteine-induced blood-brain barrier dysfunction.
Shen S, Wang J, Zhao Q, Hu Q
Bioengineered 2022 Mar;13(3):7209-7220
Bioengineered 2022 Mar;13(3):7209-7220
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Liu Y, Huang H, Xu Z, Xue Y, Zhang D, Zhang Y, Li W, Li X
Food & function 2022 Mar 7;13(5):2693-2709
Food & function 2022 Mar 7;13(5):2693-2709
Aerobic exercise promotes the expression of ATGL and attenuates inflammation to improve hepatic steatosis via lncRNA SRA.
Wu B, Xu C, Tian Y, Zeng Y, Yan F, Chen A, Zhao J, Chen L
Scientific reports 2022 Mar 30;12(1):5370
Scientific reports 2022 Mar 30;12(1):5370
FoxO1 Regulates Neuropeptide Y and Pro-opiomelanocortin in the Hypothalamus of Rat Offspring Small for Gestational Age.
Zhang L, Shi Q, Sun Y
Reproductive sciences (Thousand Oaks, Calif.) 2022 Jan;29(1):173-183
Reproductive sciences (Thousand Oaks, Calif.) 2022 Jan;29(1):173-183
SDF-1 inhibits the dedifferentiation of islet β cells in hyperglycaemia by up-regulating FoxO1 via binding to CXCR4.
Chen XY, Shi YX, Huang YP, Ding M, Shen QL, Li CJ, Lin JN
Journal of cellular and molecular medicine 2022 Feb;26(3):750-763
Journal of cellular and molecular medicine 2022 Feb;26(3):750-763
LncRNA nuclear receptor subfamily 2 group F member 1 antisense RNA 1 (NR2F1-AS1) aggravates nucleus pulposus cell apoptosis and extracellular matrix degradation.
Du L, Li X, Gao Q, Yuan P, Sun Y, Chen Y, Huang B, Deng Y, Wang B
Bioengineered 2022 Feb;13(2):2746-2762
Bioengineered 2022 Feb;13(2):2746-2762
HDAC9 Contributes to Serous Ovarian Cancer Progression through Regulating Epithelial-Mesenchymal Transition.
Xu L, Wang J, Liu B, Fu J, Zhao Y, Yu S, Shen L, Yan X, Su J
Biomedicines 2022 Feb 3;10(2)
Biomedicines 2022 Feb 3;10(2)
Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy.
Ming SL, Zhang S, Wang Q, Zeng L, Zhou LY, Wang MD, Ma YX, Han LQ, Zhong K, Zhu HS, Bai YL, Yang GY, Wang J, Chu BB
Autophagy 2022 Aug;18(8):1801-1821
Autophagy 2022 Aug;18(8):1801-1821
6-Hydroxydopamine-Induced Neurotoxicity in Rat Model of Parkinson's Disease: Is Reversed via Anti-Oxidative Activities of Curcumin and Aerobic Exercise Therapy.
Sokouti H, Mohajeri D, Nourazar MA
Physiological research 2022 Aug 31;71(4):551-560
Physiological research 2022 Aug 31;71(4):551-560
miR-486 attenuates cardiac ischemia/reperfusion injury and mediates the beneficial effect of exercise for myocardial protection.
Bei Y, Lu D, Bär C, Chatterjee S, Costa A, Riedel I, Mooren FC, Zhu Y, Huang Z, Wei M, Hu M, Liu S, Yu P, Wang K, Thum T, Xiao J
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Apr 6;30(4):1675-1691
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Apr 6;30(4):1675-1691
Genetic and Functional Evaluation of the Role of FOXO1 in Antituberculosis Drug-Induced Hepatotoxicity.
Zhang J, Jiao L, Song J, Wu T, Bai H, Liu T, Zhao Z, Hu X, Ying B
Evidence-based complementary and alternative medicine : eCAM 2021;2021:3185874
Evidence-based complementary and alternative medicine : eCAM 2021;2021:3185874
Clozapine Induced Disturbances in Hepatic Glucose Metabolism: The Potential Role of PGRMC1 Signaling.
Cao T, Chen Q, Zhang B, Wu X, Zeng C, Zhang S, Cai H
Frontiers in endocrinology 2021;12:727371
Frontiers in endocrinology 2021;12:727371
Targeting Wnt Signaling in the Tumor Immune Microenvironment to Enhancing EpCAM CAR T-Cell therapy.
Li W, Zhou Y, Wu Z, Shi Y, Tian E, Zhu Y, Wang T, Dou W, Meng X, Chen M, Zhai B, Zhu D
Frontiers in pharmacology 2021;12:724306
Frontiers in pharmacology 2021;12:724306
EZH2-Mediated microRNA-375 Upregulation Promotes Progression of Breast Cancer via the Inhibition of FOXO1 and the p53 Signaling Pathway.
Guan X, Shi A, Zou Y, Sun M, Zhan Y, Dong Y, Fan Z
Frontiers in genetics 2021;12:633756
Frontiers in genetics 2021;12:633756
TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway.
Yu HF, Zheng LW, Yang ZQ, Wang YS, Wang TT, Yue ZP, Guo B
Experimental & molecular medicine 2021 Sep;53(9):1307-1318
Experimental & molecular medicine 2021 Sep;53(9):1307-1318
Genistein exhibits therapeutic potential for PCOS mice via the ER-Nrf2-Foxo1-ROS pathway.
Luo M, Zheng LW, Wang YS, Huang JC, Yang ZQ, Yue ZP, Guo B
Food & function 2021 Sep 20;12(18):8800-8811
Food & function 2021 Sep 20;12(18):8800-8811
Activation of angiotensin-converting enzyme 2/angiotensin (1-7)/mas receptor axis triggers autophagy and suppresses microglia proinflammatory polarization via forkhead box class O1 signaling.
Dang R, Yang M, Cui C, Wang C, Zhang W, Geng C, Han W, Jiang P
Aging cell 2021 Oct;20(10):e13480
Aging cell 2021 Oct;20(10):e13480
Comparative analysis of long non‑coding RNA expression profiles induced by resveratrol and metformin treatment for hepatic insulin resistance.
Shu L, Hou X, Song G, Wang C, Ma H
International journal of molecular medicine 2021 Nov;48(5)
International journal of molecular medicine 2021 Nov;48(5)
1,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice.
Fan Y, Lu J, Liu J, Zhang R, Yu Z, Guan S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112578
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112578
Hawthorn polyphenols, D-chiro-inositol, and epigallocatechin gallate exert a synergistic hypoglycemic effect.
Xin C, Zhao M, Wang J, Wang Z
Journal of food biochemistry 2021 Jul;45(7):e13771
Journal of food biochemistry 2021 Jul;45(7):e13771
Circular RNA ubiquitin-associated protein 2 enhances autophagy and promotes colorectal cancer progression and metastasis via miR-582-5p/FOXO1 signaling.
Chen F, Guo L, Di J, Li M, Dong D, Pei D
Journal of genetics and genomics = Yi chuan xue bao 2021 Dec;48(12):1091-1103
Journal of genetics and genomics = Yi chuan xue bao 2021 Dec;48(12):1091-1103
FOXO1 inhibits prostate cancer cell proliferation via suppressing E2F1 activated NPRL2 expression.
Tang Y, Jiang L, Zhao X, Hu D, Zhao G, Luo S, Du X, Tang W
Cell biology international 2021 Dec;45(12):2510-2520
Cell biology international 2021 Dec;45(12):2510-2520
PPP2R2A affects embryonic implantation by regulating the proliferation and apoptosis of Hu sheep endometrial stromal cells.
Li X, Yao X, Xie H, Zhang G, Deng M, Deng K, Gao X, Bao Y, Li K, Wang F
Theriogenology 2021 Dec;176:149-162
Theriogenology 2021 Dec;176:149-162
Magnesium Lithospermate B Attenuates High-Fat Diet-Induced Muscle Atrophy in C57BL/6J Mice.
Cheng TL, Lin ZY, Liao KY, Huang WC, Jhuo CF, Pan PH, Chen CJ, Kuan YH, Chen WY
Nutrients 2021 Dec 27;14(1)
Nutrients 2021 Dec 27;14(1)
Resveratrol Promotes Angiogenesis in a FoxO1-Dependent Manner in Hind Limb Ischemia in Mice.
Fan D, Liu C, Guo Z, Huang K, Peng M, Li N, Luo H, Wang T, Cen Z, Cai W, Gu L, Chen S, Li Z
Molecules (Basel, Switzerland) 2021 Dec 12;26(24)
Molecules (Basel, Switzerland) 2021 Dec 12;26(24)
circEVI5 acts as a miR-4793-3p sponge to suppress the proliferation of gastric cancer.
Yan M, Niu L, Liu J, Yao Y, Li H
Cell death & disease 2021 Aug 5;12(8):774
Cell death & disease 2021 Aug 5;12(8):774
Liver kinase B1 attenuates liver ischemia/reperfusion injury via inhibiting the NLRP3 inflammasome.
Dai J, Chen Q, Huang W, Shi K, Zhang Y, Li T, Mou T, Huang Z, Wu Z
Acta biochimica et biophysica Sinica 2021 Apr 15;53(5):601-611
Acta biochimica et biophysica Sinica 2021 Apr 15;53(5):601-611
FOXO1 and hsa-microRNA-204-5p affect the biologic behavior of MDA-MB-231 breast cancer cells.
Liang CY, Huang ZG, Tang ZQ, Xiao XL, Zeng JJ, Feng ZB
International journal of clinical and experimental pathology 2020;13(5):1146-1158
International journal of clinical and experimental pathology 2020;13(5):1146-1158
Resveratrol Upregulates mmu-miR-363-3p via the PI3K-Akt Pathway to Improve Insulin Resistance Induced by a High-Fat Diet in Mice.
Shu L, Zhao H, Huang W, Hou G, Song G, Ma H
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:391-403
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:391-403
Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1.
Yang Y, Wang Y, He Z, Liu Y, Chen C, Wang Y, Wang DW, Wang H
Frontiers in pharmacology 2020;11:1136
Frontiers in pharmacology 2020;11:1136
FUT4siRNA augments the chemosensitivity of non-small cell lung cancer to cisplatin through activation of FOXO1-induced apoptosis.
Gao W, Liang J, Ye Y, Lu J, Lin T, Wang N, Dong J, Pan J
BMC cancer 2020 Sep 18;20(1):895
BMC cancer 2020 Sep 18;20(1):895
Activation of Sirtuin1 by lyceum barbarum polysaccharides in protection against diabetic cataract.
Yao Q, Zhou Y, Yang Y, Cai L, Xu L, Han X, Guo Y, Li PA
Journal of ethnopharmacology 2020 Oct 28;261:113165
Journal of ethnopharmacology 2020 Oct 28;261:113165
Serpina3c protects against high-fat diet-induced pancreatic dysfunction through the JNK-related pathway.
Ji JJ, Qian LL, Zhu Y, Wu YP, Guo JQ, Ma GS, Yao YY
Cellular signalling 2020 Nov;75:109745
Cellular signalling 2020 Nov;75:109745
CDKL3 promotes osteosarcoma progression by activating Akt/PKB.
He A, Ma L, Huang Y, Zhang H, Duan W, Li Z, Fei T, Yuan J, Wu H, Liu L, Bai Y, Dai W, Wang Y, Li H, Sun Y, Wang Y, Wang C, Yuan T, Yang Q, Tian S, Dong M, Sheng R, Xiang D
Life science alliance 2020 May;3(5)
Life science alliance 2020 May;3(5)
Influence of feature rankers in the construction of molecular activity prediction models.
Cerruela-García G, Pérez-Parra Toledano J, de Haro-García A, García-Pedrajas N
Journal of computer-aided molecular design 2020 Mar;34(3):305-325
Journal of computer-aided molecular design 2020 Mar;34(3):305-325
Tectorigenin attenuates diabetic nephropathy by improving vascular endothelium dysfunction through activating AdipoR1/2 pathway.
Yang S, Ma C, Wu H, Zhang H, Yuan F, Yang G, Yang Q, Jia L, Liang Z, Kang L
Pharmacological research 2020 Mar;153:104678
Pharmacological research 2020 Mar;153:104678
MSC-Secreted Exosomal H19 Promotes Trophoblast Cell Invasion and Migration by Downregulating let-7b and Upregulating FOXO1.
Chen Y, Ding H, Wei M, Zha W, Guan S, Liu N, Li Y, Tan Y, Wang Y, Wu F
Molecular therapy. Nucleic acids 2020 Mar 6;19:1237-1249
Molecular therapy. Nucleic acids 2020 Mar 6;19:1237-1249
Using ESTIMATE algorithm to establish an 8-mRNA signature prognosis prediction system and identify immunocyte infiltration-related genes in Pancreatic adenocarcinoma.
Meng Z, Ren D, Zhang K, Zhao J, Jin X, Wu H
Aging 2020 Mar 17;12(6):5048-5070
Aging 2020 Mar 17;12(6):5048-5070
The Human Novel Gene LNC-HC Inhibits Hepatocellular Carcinoma Cell Proliferation by Sequestering hsa-miR-183-5p.
Lan X, Wu N, Wu L, Qu K, Osoro EK, Guan D, Du X, Wang B, Chen S, Miao J, Ren J, Liu L, Li H, Ning Q, Li D, Lu S
Molecular therapy. Nucleic acids 2020 Jun 5;20:468-479
Molecular therapy. Nucleic acids 2020 Jun 5;20:468-479
Electroacupuncture ameliorates cerebral ischemia/reperfusion injury by suppressing autophagy via the SIRT1-FOXO1 signaling pathway.
Mei ZG, Huang YG, Feng ZT, Luo YN, Yang SB, Du LP, Jiang K, Liu XL, Fu XY, Deng YH, Zhou HJ
Aging 2020 Jul 3;12(13):13187-13205
Aging 2020 Jul 3;12(13):13187-13205
LncRNA MBNL1-AS1 represses cell proliferation and enhances cell apoptosis via targeting miR-135a-5p/PHLPP2/FOXO1 axis in bladder cancer.
Wei X, Yang X, Wang B, Yang Y, Fang Z, Yi C, Shi L, Song D
Cancer medicine 2020 Jan;9(2):724-736
Cancer medicine 2020 Jan;9(2):724-736
Tamoxifen induces fatty liver disease in breast cancer through the MAPK8/FoxO pathway.
Gong L, Tang H, Luo Z, Sun X, Tan X, Xie L, Lei Y, Cai M, He C, Ma J, Han S
Clinical and translational medicine 2020 Jan;10(1):137-150
Clinical and translational medicine 2020 Jan;10(1):137-150
Calcium relieves fluoride-induced bone damage through the PI3K/AKT pathway.
Wang J, Xu H, Cheng X, Yang J, Yan Z, Ma H, Zhao Y, Ommati MM, Manthari RK, Wang J
Food & function 2020 Jan 29;11(1):1155-1164
Food & function 2020 Jan 29;11(1):1155-1164
Long non-coding RNA expression profiling following treatment with resveratrol to improve insulin resistance.
Shu L, Hou G, Zhao H, Huang W, Song G, Ma H
Molecular medicine reports 2020 Aug;22(2):1303-1316
Molecular medicine reports 2020 Aug;22(2):1303-1316
Self-Therapeutic Nanoparticle That Alters Tau Protein and Ameliorates Tauopathy Toward a Functional Nanomedicine to Tackle Alzheimer's.
Vimal SK, Zuo H, Wang Z, Wang H, Long Z, Bhattacharyya S
Small (Weinheim an der Bergstrasse, Germany) 2020 Apr;16(16):e1906861
Small (Weinheim an der Bergstrasse, Germany) 2020 Apr;16(16):e1906861
MiR-21-3p Plays a Crucial Role in Metabolism Alteration of Renal Tubular Epithelial Cells during Sepsis Associated Acute Kidney Injury via AKT/CDK2-FOXO1 Pathway.
Lin Z, Liu Z, Wang X, Qiu C, Zheng S
BioMed research international 2019;2019:2821731
BioMed research international 2019;2019:2821731
Resveratrol affects hepatic gluconeogenesis via histone deacetylase 4.
Zhao H, Shu L, Huang W, Song G, Ma H
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:401-411
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:401-411
Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal.
Song S, Chu L, Liang H, Chen J, Liang J, Huang Z, Zhang B, Chen X
Frontiers in pharmacology 2019;10:1030
Frontiers in pharmacology 2019;10:1030
Partially Hydrolyzed Guar Gum Attenuates d-Galactose-Induced Oxidative Stress and Restores Gut Microbiota in Rats.
Liu X, Wu C, Han D, Liu J, Liu H, Jiang Z
International journal of molecular sciences 2019 Sep 30;20(19)
International journal of molecular sciences 2019 Sep 30;20(19)
Anti-ageing and antioxidant effects of sulfate oligosaccharides from green algae Ulva lactuca and Enteromorpha prolifera in SAMP8 mice.
Liu XY, Liu D, Lin GP, Wu YJ, Gao LY, Ai C, Huang YF, Wang MF, El-Seedi HR, Chen XH, Zhao C
International journal of biological macromolecules 2019 Oct 15;139:342-351
International journal of biological macromolecules 2019 Oct 15;139:342-351
Young Blood Rescues the Cognition of Alzheimer's Model Mice by Restoring the Hippocampal Cholinergic Circuit.
Xia E, Xu F, Hu C, Kumal JPP, Tang X, Mao D, Li Y, Wu D, Zhang R, Wu S, Sun L
Neuroscience 2019 Oct 1;417:57-69
Neuroscience 2019 Oct 1;417:57-69
Promising therapeutic effect of thapsigargin nanoparticles on chronic kidney disease through the activation of Nrf2 and FoxO1.
Cheng FY, Lee YH, Hsu YH, Chiu IJ, Chiu YJ, Lin YF, Chiu HW
Aging 2019 Nov 12;11(21):9875-9892
Aging 2019 Nov 12;11(21):9875-9892
Sweroside Alleviated LPS-Induced Inflammation via SIRT1 Mediating NF-κB and FOXO1 Signaling Pathways in RAW264.7 Cells.
Wang R, Dong Z, Lan X, Liao Z, Chen M
Molecules (Basel, Switzerland) 2019 Mar 1;24(5)
Molecules (Basel, Switzerland) 2019 Mar 1;24(5)
Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol.
Guo Y, Zhao M, Bo T, Ma S, Yuan Z, Chen W, He Z, Hou X, Liu J, Zhang Z, Zhu Q, Wang Q, Lin X, Yang Z, Cui M, Liu L, Li Y, Yu C, Qi X, Wang Q, Zhang H, Guan Q, Zhao L, Xuan S, Yan H, Lin Y, Wang L, Li Q, Song Y, Gao L, Zhao J
Cell research 2019 Feb;29(2):151-166
Cell research 2019 Feb;29(2):151-166
Oxaliplatin reverses the GLP-1R-mediated promotion of intrahepatic cholangiocarcinoma by altering FoxO1 signaling.
Chen B, Zhou W, Zhao W, Yuan P, Tang C, Wang G, Leng J, Ma J, Wang X, Hui Y, Wang Q
Oncology letters 2019 Aug;18(2):1989-1998
Oncology letters 2019 Aug;18(2):1989-1998
Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells.
Wang F, Chang C, Li R, Zhang Z, Jiang H, Zeng N, Li D, Chen L, Xiao Y, Chen W, Wang Q
Toxicology 2019 Aug 1;424:152236
Toxicology 2019 Aug 1;424:152236
Glutathione prevents chronic oscillating glucose intake-induced β-cell dedifferentiation and failure.
Zhang J, An H, Ni K, Chen B, Li H, Li Y, Sheng G, Zhou C, Xie M, Chen S, Zhou T, Yang G, Chen X, Wu G, Jin S, Li M
Cell death & disease 2019 Apr 11;10(4):321
Cell death & disease 2019 Apr 11;10(4):321
Identification of the key genes and pathways in prostate cancer.
Fan S, Liang Z, Gao Z, Pan Z, Han S, Liu X, Zhao C, Yang W, Pan Z, Feng W
Oncology letters 2018 Nov;16(5):6663-6669
Oncology letters 2018 Nov;16(5):6663-6669
AMPK alleviates endoplasmic reticulum stress by inducing the ER-chaperone ORP150 via FOXO1 to protect human bronchial cells from apoptosis.
Liu JQ, Zhang L, Yao J, Yao S, Yuan T
Biochemical and biophysical research communications 2018 Mar 4;497(2):564-570
Biochemical and biophysical research communications 2018 Mar 4;497(2):564-570
Japanese encephalitis virus induces apoptosis by inhibiting Foxo signaling pathway.
Guo F, Yu X, Xu A, Xu J, Wang Q, Guo Y, Wu X, Tang Y, Ding Z, Zhang Y, Gong T, Pan Z, Li S, Kong L
Veterinary microbiology 2018 Jul;220:73-82
Veterinary microbiology 2018 Jul;220:73-82
Amino acid starvation-induced autophagy is involved in reduced subcutaneous fat deposition in weaning piglets derived from sows fed low-protein diet during gestation and lactation : Autophagy is involved in reduced fat deposition in maternal low-protein piglets.
Pan S, Jia Y, Yang X, Cai D, Liu Z, Song H, Zhao R
European journal of nutrition 2018 Apr;57(3):991-1001
European journal of nutrition 2018 Apr;57(3):991-1001
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.
Yan J, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, Liu K, Sun H
Pharmacological research 2018 Apr;130:466-480
Pharmacological research 2018 Apr;130:466-480
High glucose induces apoptosis via upregulation of Bim expression in proximal tubule epithelial cells.
Zhang XQ, Dong JJ, Cai T, Shen X, Zhou XJ, Liao L
Oncotarget 2017 Apr 11;8(15):24119-24129
Oncotarget 2017 Apr 11;8(15):24119-24129
RGD liposome-protamine-siRNA (LPR) nanoparticles targeting PAX3-FOXO1 for alveolar rhabdomyosarcoma therapy.
Rengaswamy V, Zimmer D, Süss R, Rössler J
Journal of controlled release : official journal of the Controlled Release Society 2016 Aug 10;235:319-327
Journal of controlled release : official journal of the Controlled Release Society 2016 Aug 10;235:319-327
MicroRNA-96 plays an oncogenic role by targeting FOXO1 and regulating AKT/FOXO1/Bim pathway in papillary thyroid carcinoma cells.
Song HM, Luo Y, Li DF, Wei CK, Hua KY, Song JL, Xu H, Maskey N, Fang L
International journal of clinical and experimental pathology 2015;8(9):9889-900
International journal of clinical and experimental pathology 2015;8(9):9889-900
VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in caenorhabditis elegans.
Han SM, El Oussini H, Scekic-Zahirovic J, Vibbert J, Cottee P, Prasain JK, Bellen HJ, Dupuis L, Miller MA
PLoS genetics 2013;9(9):e1003738
PLoS genetics 2013;9(9):e1003738
Caffeic acid phenethyl ester synergistically enhances docetaxel and paclitaxel cytotoxicity in prostate cancer cells.
Tolba MF, Esmat A, Al-Abd AM, Azab SS, Khalifa AE, Mosli HA, Abdel-Rahman SZ, Abdel-Naim AB
IUBMB life 2013 Aug;65(8):716-29
IUBMB life 2013 Aug;65(8):716-29
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FOXO1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human FOXO1. This antibody recognizes human, mouse, rat antigen. The FOXO1 antibody has been validated for the following applications: ELISA, WB analysis.
