Antibody data
- Antibody Data
- Antigen structure
- References [66]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
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- Product number
- 14887-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14887-1-AP, RRID:AB_2120458
- Product name
- GRP75 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated GRP75 antibody (Cat. #14887-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references SIRT3 promotes oxaliplatin sensitivity in hepatocellular carcinoma by promoting ferroptosis through endoplasmic reticulum stress response.
STIM1-containing contact sites promote direct calcium flux from the endoplasmic reticulum to mitochondria.
Modulating GRP75 to restore calcium homeostasis: a novel neuroprotective strategy of CRSE6(#) in Parkinson's disease models.
Novel BLT1 inhibitor baeckein E ameliorates LPS-induced acute lung injury through ferroptosis inhibition.
Super enhancer-driven LINC01013 mediates hypoxia-induced mitochondrial dysfunction by HSPA9 to determine pulmonary arterial smooth muscle cell fate.
GRP75 blocks hepatitis E virus infection by targeting HEV-ORF2 for degradation through chaperone-mediated autophagy and promoting IRF3 activation.
Metformin improves intestinal ischemia-reperfusion injury by reducing the formation of mitochondrial associated endoplasmic reticulum membranes (MAMs) and inhibiting ferroptosis in intestinal cells.
Congrong Shujing Granules ameliorates mitochondrial associated membranes to against MPP(+)-induced neurological damage in the cellular model of Parkinson's disease.
Cardioprotective effect of Yiqi Huoxue decoction on post-myocardial infarction injury mediated by Ca(2+) flux through MAMs.
Wharton's Jelly Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Intervertebral Disc Degeneration Under Inflammatory Stress in an In Vitro 3D Culture System.
SIRT1 Alleviates Oxidative Stress-Induced Mitochondrial Dysfunction and Mitochondria-Associated Membrane Dysregulation in Stress Urinary Incontinence.
Discovery of a potent inhibitor of chaperone-mediated autophagy that targets the HSC70-LAMP2A interaction in non-small cell lung cancer cells.
USP51/GRP78/ABCB1 axis confers chemoresistance through decreasing doxorubicin accumulation in triple-negative breast cancer cells.
HSPA9 contributes to tumor progression and ferroptosis resistance by enhancing USP14-driven SLC7A11 deubiquitination in multiple myeloma.
AKAP1/PKA-mediated GRP75 phosphorylation at mitochondria-associated endoplasmic reticulum membranes protects cancer cells against ferroptosis.
Ca(2+) transfer via enhancing ER-Mito coupling contributed to BDE-47- induced hippocampal neuronal necroptosis and cognitive dysfunction.
The mitochondrial DNAJC co-chaperone TCAIM reduces α-ketoglutarate dehydrogenase protein levels to regulate metabolism.
Intranasal insulin administration affecting perioperative neurocognitive dysfunction by regulating calcium transport protein complex IP3R/GRP75/VDAC1 on MAMs.
LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes.
SUMO E3 ligase MUL1 inhibits lymph node metastasis of bladder cancer by mediating mitochondrial HSPA9 translocation.
GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia.
ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca(2+) uptake and oxidative metabolism.
PDZD8 Augments Endoplasmic Reticulum-Mitochondria Contact and Regulates Ca2+ Dynamics and Cypd Expression to Induce Pancreatic β-Cell Death during Diabetes.
Mitochondrial Iron Metabolism as a Potential Key Mediator of PD-L1 Thermal Regulation.
Edaravone counteracts redox and metabolic disruptions in an emerging zebrafish model of sporadic ALS.
Wharton's Jelly mesenchymal stromal cell-derived extracellular vesicles promote nucleus pulposus cell anabolism in an in vitro 3D alginate-bead culture model.
Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury.
Augmented microglial endoplasmic reticulum-mitochondria contacts mediate depression-like behavior in mice induced by chronic social defeat stress.
Mechanism of apoptosis induced by the combined action of acrylamide and Elaidic acid through endoplasmic reticulum stress injury.
Drp1 Aggravates Copper Nanoparticle-Induced ER-Phagy by Disturbing Mitochondria-Associated Membranes in Chicken Hepatocytes.
Tumor suppressor KEAP1 promotes HSPA9 degradation, controlling mitochondrial biogenesis in breast cancer.
Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus.
The anticancer effect of metformin targets VDAC1 via ER-mitochondria interactions-mediated autophagy in HCC.
NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination.
Xbp1 promotes odontoblastic differentiation through modulating mitochondrial homeostasis.
Stress response mechanisms in protein misfolding diseases: Profiling a cellular model of Huntington's disease.
CCDC127 regulates lipid droplet homeostasis by enhancing mitochondria-ER contacts.
Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats.
SIRT3 ameliorates diabetes-associated cognitive dysfunction via regulating mitochondria-associated ER membranes.
Disruption of Mitochondrial-associated ER membranes by HIV-1 tat protein contributes to premature brain aging.
The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition.
Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
Role of human HSPE1 for OPA1 processing independent of HSPD1.
Endoplasmic Reticulum Protein TXNDC5 Interacts with PRDX6 and HSPA9 to Regulate Glutathione Metabolism and Lipid Peroxidation in the Hepatic AML12 Cell Line.
Advanced oxidation protein products induce Paneth cells defects by endoplasmic reticulum stress in Crohn's disease.
TOM complex-independent transport pathway of myoglobin into mitochondria in C2C12 myotubes.
Development of a Novel Circulating Autoantibody Biomarker Panel for the Identification of Patients with 'Actionable' Pulmonary Nodules.
Disruption of mitochondria-associated ER membranes impairs insulin sensitivity and thermogenic function of adipocytes.
AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology.
GRP75-driven, cell-cycle-dependent macropinocytosis of Tat/pDNA-Ca(2+) nanoparticles underlies distinct gene therapy effect in ovarian cancer.
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
Allosteric activation of Hsp70 reduces mutant huntingtin levels, the clustering of N-terminal fragments, and their nuclear accumulation.
LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding.
N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties.
Mitochondrial DNA Haplogroup M7 Confers Disability in a Chinese Aging Population.
ATF4 Mediates Mitochondrial Unfolded Protein Response in Alveolar Epithelial Cells.
TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response.
Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology.
LONP1 Is Required for Maturation of a Subset of Mitochondrial Proteins, and Its Loss Elicits an Integrated Stress Response.
TP53-induced glycolysis and apoptosis regulator is indispensable for mitochondria quality control and degradation following damage.
FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.
Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.
ABT737 reverses cisplatin resistance by regulating ER-mitochondria Ca2+ signal transduction in human ovarian cancer cells.
DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling.
Upregulation of phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in acquired middle ear cholesteatoma growth.
An investigation into the cytotoxic effects of 13-acetoxysarcocrassolide from the soft coral Sarcophyton crassocaule on bladder cancer cells.
Xu Y, Ma C, Xu X, Tu J, Chen X, Yang X, Sun D, Liu S, Wan Y, Qin L, Gu W, Qian H
Pathology, research and practice 2026 May;281:156400
Pathology, research and practice 2026 May;281:156400
STIM1-containing contact sites promote direct calcium flux from the endoplasmic reticulum to mitochondria.
Orantos-Aguilera Y, Sanchez-Lopez I, Pascual-Caro C, Gómez-Suaga P, Area-Gomez E, Pozo-Guisado E, Montesinos J, Martin-Romero FJ
The EMBO journal 2026 Mar;45(5):1760-1793
The EMBO journal 2026 Mar;45(5):1760-1793
Modulating GRP75 to restore calcium homeostasis: a novel neuroprotective strategy of CRSE6(#) in Parkinson's disease models.
Wang X, Li S, Xiang X, Zhang X, Yu C, Qing D, Law BY, Tang Y
Journal of advanced research 2026 Mar 19;
Journal of advanced research 2026 Mar 19;
Novel BLT1 inhibitor baeckein E ameliorates LPS-induced acute lung injury through ferroptosis inhibition.
Mi Y, Wang R, Qian J, Liu Z, Li Y, Fan H, Wang L, Kuai H, Xiong F, Wang H, Shi X, Hu X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158147
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158147
Super enhancer-driven LINC01013 mediates hypoxia-induced mitochondrial dysfunction by HSPA9 to determine pulmonary arterial smooth muscle cell fate.
Ma C, Wang Z, Zhu X, Pang X, Zhang L, Ou L, Chen Y, Liu Y, Mei J, Guan X, Meng Z, Tang Y, Zhang Z, Li B, Wen S, Shen A, Wang X
Cellular and molecular life sciences : CMLS 2026 Jan 6;83(1):57
Cellular and molecular life sciences : CMLS 2026 Jan 6;83(1):57
GRP75 blocks hepatitis E virus infection by targeting HEV-ORF2 for degradation through chaperone-mediated autophagy and promoting IRF3 activation.
Wang Y, Li Y, Xu R, Yuan T, Xu C, Zhou Z, Ba C, Zhao Q, Wu C, An Z, Yin X, Yang Y, Nan Y
Journal of virology 2026 Jan 20;100(1):e0134425
Journal of virology 2026 Jan 20;100(1):e0134425
Metformin improves intestinal ischemia-reperfusion injury by reducing the formation of mitochondrial associated endoplasmic reticulum membranes (MAMs) and inhibiting ferroptosis in intestinal cells.
Zhao X, Yan L, Tian L, Zhang X, Liu R, Li Z
Frontiers in pharmacology 2025;16:1581085
Frontiers in pharmacology 2025;16:1581085
Congrong Shujing Granules ameliorates mitochondrial associated membranes to against MPP(+)-induced neurological damage in the cellular model of Parkinson's disease.
Zhang C, Huang P, Cheng H, Yuan X, Zhou M, Liu Y, Liu T, Chen D, Xu Q, Cai J
Frontiers in pharmacology 2025;16:1509317
Frontiers in pharmacology 2025;16:1509317
Cardioprotective effect of Yiqi Huoxue decoction on post-myocardial infarction injury mediated by Ca(2+) flux through MAMs.
Li Y, Du T, Zhang Y, Lu Y, Li X, Xie W, Guo S
Frontiers in cardiovascular medicine 2025;12:1596757
Frontiers in cardiovascular medicine 2025;12:1596757
Wharton's Jelly Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Intervertebral Disc Degeneration Under Inflammatory Stress in an In Vitro 3D Culture System.
Tilotta V, Vadalà G, Di Giacomo G, Ambrosio L, Cicione C, Russo F, Darinskas A, Papalia R, Denaro V
JOR spine 2025 Sep;8(3):e70106
JOR spine 2025 Sep;8(3):e70106
SIRT1 Alleviates Oxidative Stress-Induced Mitochondrial Dysfunction and Mitochondria-Associated Membrane Dysregulation in Stress Urinary Incontinence.
Chen L, Tang J, Zuo X, Li B, Liu C, Hong S, Min J, Hu M, Li S, Zhou M, Chen M, He Y, Xiao Y, Huang X, Hong L
Cell proliferation 2025 May;58(5):e70009
Cell proliferation 2025 May;58(5):e70009
Discovery of a potent inhibitor of chaperone-mediated autophagy that targets the HSC70-LAMP2A interaction in non-small cell lung cancer cells.
Dong RF, Qin CJ, Yin Y, Han LL, Xiao CM, Wang KD, Wei RY, Xia YZ, Kong LY
British journal of pharmacology 2025 May;182(10):2287-2309
British journal of pharmacology 2025 May;182(10):2287-2309
USP51/GRP78/ABCB1 axis confers chemoresistance through decreasing doxorubicin accumulation in triple-negative breast cancer cells.
Ou Y, Zhang K, Shuai Q, Wang C, Hu H, Cao L, Qi C, Guo M, Li Z, Shi J, Liu Y, Zuo S, Chen X, Wang Y, Feng M, Wang H, Sun P, Shi Y, Yang G, Yang S
Acta pharmaceutica Sinica. B 2025 May;15(5):2593-2611
Acta pharmaceutica Sinica. B 2025 May;15(5):2593-2611
HSPA9 contributes to tumor progression and ferroptosis resistance by enhancing USP14-driven SLC7A11 deubiquitination in multiple myeloma.
Shen N, Xia Y, Shen X, Hua W, Shi M, Chen L
Cell reports 2025 May 27;44(5):115720
Cell reports 2025 May 27;44(5):115720
AKAP1/PKA-mediated GRP75 phosphorylation at mitochondria-associated endoplasmic reticulum membranes protects cancer cells against ferroptosis.
Liu H, Zheng S, Hou G, Dai J, Zhao Y, Yang F, Xiang Z, Zhang W, Wang X, Gong Y, Li L, Zhang N, Hu Y
Cell death and differentiation 2025 Mar;32(3):488-505
Cell death and differentiation 2025 Mar;32(3):488-505
Ca(2+) transfer via enhancing ER-Mito coupling contributed to BDE-47- induced hippocampal neuronal necroptosis and cognitive dysfunction.
Geng J, Yuan Q, Ni C, Zhang Y, Liu X, Zhu X, Hao X, Liang G, Wang D, Fan H
Ecotoxicology and environmental safety 2025 Jul 1;299:118396
Ecotoxicology and environmental safety 2025 Jul 1;299:118396
The mitochondrial DNAJC co-chaperone TCAIM reduces α-ketoglutarate dehydrogenase protein levels to regulate metabolism.
Jiahui W, Xiang Y, Youhuan Z, Xiaomin M, Yuanzhu G, Dejian Z, Jie W, Yinkun F, Shi F, Juncheng S, Masha H, Marcia H, Peiyi W, Yingjie X, Wen Y
Molecular cell 2025 Feb 6;85(3):638-651.e9
Molecular cell 2025 Feb 6;85(3):638-651.e9
Intranasal insulin administration affecting perioperative neurocognitive dysfunction by regulating calcium transport protein complex IP3R/GRP75/VDAC1 on MAMs.
Liu H, Jiang Y, Cong L, Zhang X, Zhou Y, Pan X, Liu S, Wang R, Cao X
Free radical biology & medicine 2025 Feb 16;228:240-250
Free radical biology & medicine 2025 Feb 16;228:240-250
LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes.
Li J, Deng Y, Gasser M, Zhu J, Walker EM, Sidarala V, Reck EC, Hubers DL, Pasmooij MB, Shin CS, Bandesh K, Motakis E, Nargund S, Kursawe R, Basrur V, Nesvizhskii AI, Stitzel ML, Chan DC, Rutter GA, Soleimanpour SA
Nature metabolism 2025 Aug;7(8):1570-1592
Nature metabolism 2025 Aug;7(8):1570-1592
SUMO E3 ligase MUL1 inhibits lymph node metastasis of bladder cancer by mediating mitochondrial HSPA9 translocation.
Wu J, Huang M, Dong W, Chen Y, Zhou Q, Zhang Q, Zheng J, Liu Y, Zhang Y, Liu S, Yang C, Chen S, Huang J, Lin T, Chen X
International journal of biological sciences 2024;20(10):3986-4006
International journal of biological sciences 2024;20(10):3986-4006
GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia.
Chen X, Wu Q, Gong W, Ju S, Fan J, Gao X, Liu X, Lei X, Liu S, Ming X, Wang Q, Fu M, Song Y, Wang Y, Zhan Q
Signal transduction and targeted therapy 2024 Sep 26;9(1):253
Signal transduction and targeted therapy 2024 Sep 26;9(1):253
ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca(2+) uptake and oxidative metabolism.
Dematteis G, Tapella L, Casali C, Talmon M, Tonelli E, Reano S, Ariotti A, Pessolano E, Malecka J, Chrostek G, Kulkovienė G, Umbrasas D, Distasi C, Grilli M, Ladds G, Filigheddu N, Fresu LG, Mikoshiba K, Matute C, Ramos-Gonzalez P, Jekabsone A, Calì T, Brini M, Biggiogera M, Cavaliere F, Miggiano R, Genazzani AA, Lim D
Communications biology 2024 Oct 10;7(1):1294
Communications biology 2024 Oct 10;7(1):1294
PDZD8 Augments Endoplasmic Reticulum-Mitochondria Contact and Regulates Ca2+ Dynamics and Cypd Expression to Induce Pancreatic β-Cell Death during Diabetes.
Liu Y, Wei Y, Jin X, Cai H, Chen Q, Zhang X
Diabetes & metabolism journal 2024 Nov;48(6):1058-1072
Diabetes & metabolism journal 2024 Nov;48(6):1058-1072
Mitochondrial Iron Metabolism as a Potential Key Mediator of PD-L1 Thermal Regulation.
Keeler G, Owusu SB, Zanaty M, Petronek MS
Cancers 2024 Nov 5;16(22)
Cancers 2024 Nov 5;16(22)
Edaravone counteracts redox and metabolic disruptions in an emerging zebrafish model of sporadic ALS.
Oliveira NAS, Pinho BR, Pinto J, Guedes de Pinho P, Oliveira JMA
Free radical biology & medicine 2024 May 1;217:126-140
Free radical biology & medicine 2024 May 1;217:126-140
Wharton's Jelly mesenchymal stromal cell-derived extracellular vesicles promote nucleus pulposus cell anabolism in an in vitro 3D alginate-bead culture model.
Tilotta V, Vadalà G, Ambrosio L, Di Giacomo G, Cicione C, Russo F, Darinskas A, Papalia R, Denaro V
JOR spine 2024 Mar;7(1):e1274
JOR spine 2024 Mar;7(1):e1274
Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury.
Li Y, Wang HB, Cao JL, Zhang WJ, Wang HL, Xu CH, Li KP, Liu Y, Wang JR, Ha HL, Fu SJ, Yang L
Journal of translational medicine 2024 Mar 10;22(1):261
Journal of translational medicine 2024 Mar 10;22(1):261
Augmented microglial endoplasmic reticulum-mitochondria contacts mediate depression-like behavior in mice induced by chronic social defeat stress.
Zhang JR, Shen SY, Zhai MY, Shen ZQ, Li W, Liang LF, Yin SY, Han QQ, Li B, Zhang YQ, Yu J
Nature communications 2024 Jun 18;15(1):5199
Nature communications 2024 Jun 18;15(1):5199
Mechanism of apoptosis induced by the combined action of acrylamide and Elaidic acid through endoplasmic reticulum stress injury.
Yuan Y, Wang X, Li L, Wang Z, Li W, Pang Y, Yan H
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Jul;189:114733
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Jul;189:114733
Drp1 Aggravates Copper Nanoparticle-Induced ER-Phagy by Disturbing Mitochondria-Associated Membranes in Chicken Hepatocytes.
Li Q, Guo P, Wang S, Su L, Yu W, Guo J, Hu L, Zhang H, Pan J, Tang Z, Liao J
Journal of agricultural and food chemistry 2024 Jul 24;72(29):16506-16518
Journal of agricultural and food chemistry 2024 Jul 24;72(29):16506-16518
Tumor suppressor KEAP1 promotes HSPA9 degradation, controlling mitochondrial biogenesis in breast cancer.
Han B, Zhen F, Sun Y, Sun B, Wang HY, Liu W, Huang J, Liang X, Wang YR, Chen XS, Li SJ, Hu J
Cell reports 2024 Jul 23;43(7):114507
Cell reports 2024 Jul 23;43(7):114507
Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus.
Bertino F, Mukherjee D, Bonora M, Bagowski C, Nardelli J, Metani L, Zanin Venturini DI, Chianese D, Santander N, Salaroglio IC, Hentschel A, Quarta E, Genova T, McKinney AA, Allocco AL, Fiorito V, Petrillo S, Ammirata G, De Giorgio F, Dennis E, Allington G, Maier F, Shoukier M, Gloning KP, Munaron L, Mussano F, Salsano E, Pareyson D, di Rocco M, Altruda F, Panagiotakos G, Kahle KT, Gressens P, Riganti C, Pinton PP, Roos A, Arnold T, Tolosano E, Chiabrando D
Cell reports. Medicine 2024 Jul 16;5(7):101647
Cell reports. Medicine 2024 Jul 16;5(7):101647
The anticancer effect of metformin targets VDAC1 via ER-mitochondria interactions-mediated autophagy in HCC.
Ko M, Kim J, Lazim R, Lee JY, Kim JY, Gosu V, Lee Y, Choi S, Kwon HJ
Experimental & molecular medicine 2024 Dec;56(12):2714-2725
Experimental & molecular medicine 2024 Dec;56(12):2714-2725
NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination.
Jeon P, Ham HJ, Choi H, Park S, Jang JW, Park SW, Cho DH, Lee HJ, Song HK, Komatsu M, Han D, Jang DJ, Lee JA
Nature communications 2024 Dec 30;15(1):10925
Nature communications 2024 Dec 30;15(1):10925
Xbp1 promotes odontoblastic differentiation through modulating mitochondrial homeostasis.
Huang D, Li Y, Han J, Zuo H, Liu H, Chen Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Apr 15;38(7):e23600
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Apr 15;38(7):e23600
Stress response mechanisms in protein misfolding diseases: Profiling a cellular model of Huntington's disease.
Almeida LM, Oliveira Â, Oliveira JMA, Pinho BR
Archives of biochemistry and biophysics 2023 Sep 1;745:109711
Archives of biochemistry and biophysics 2023 Sep 1;745:109711
CCDC127 regulates lipid droplet homeostasis by enhancing mitochondria-ER contacts.
Xia Y, Zhang Y, Sun Y, He L
Biochemical and biophysical research communications 2023 Nov 26;683:149116
Biochemical and biophysical research communications 2023 Nov 26;683:149116
Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats.
Wang Y, Miao Z, Xu C, Cai Y, Yang Y, Hu Y, Zhao M, Shao Y, Li Z, Chen J, Chen S, Wang L
Cell death & disease 2023 May 13;14(5):325
Cell death & disease 2023 May 13;14(5):325
SIRT3 ameliorates diabetes-associated cognitive dysfunction via regulating mitochondria-associated ER membranes.
Chang Y, Wang C, Zhu J, Zheng S, Sun S, Wu Y, Jiang X, Li L, Ma R, Li G
Journal of translational medicine 2023 Jul 22;21(1):494
Journal of translational medicine 2023 Jul 22;21(1):494
Disruption of Mitochondrial-associated ER membranes by HIV-1 tat protein contributes to premature brain aging.
Arjona SP, Allen CNS, Santerre M, Gross S, Soboloff J, Booze R, Sawaya BE
CNS neuroscience & therapeutics 2023 Jan;29(1):365-377
CNS neuroscience & therapeutics 2023 Jan;29(1):365-377
The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition.
Ganji R, Paulo JA, Xi Y, Kline I, Zhu J, Clemen CS, Weihl CC, Purdy JG, Gygi SP, Raman M
Nature communications 2023 Feb 6;14(1):638
Nature communications 2023 Feb 6;14(1):638
Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
Mabanglo MF, Wong KS, Barghash MM, Leung E, Chuang SHW, Ardalan A, Majaesic EM, Wong CJ, Zhang S, Lang H, Karanewsky DS, Iwanowicz AA, Graves LM, Iwanowicz EJ, Gingras AC, Houry WA
Structure (London, England : 1993) 2023 Feb 2;31(2):185-200.e10
Structure (London, England : 1993) 2023 Feb 2;31(2):185-200.e10
Role of human HSPE1 for OPA1 processing independent of HSPD1.
Yeung N, Murata D, Iijima M, Sesaki H
iScience 2023 Feb 17;26(2):106067
iScience 2023 Feb 17;26(2):106067
Endoplasmic Reticulum Protein TXNDC5 Interacts with PRDX6 and HSPA9 to Regulate Glutathione Metabolism and Lipid Peroxidation in the Hepatic AML12 Cell Line.
Bidooki SH, Sánchez-Marco J, Martínez-Beamonte R, Herrero-Continente T, Navarro MA, Rodríguez-Yoldi MJ, Osada J
International journal of molecular sciences 2023 Dec 5;24(24)
International journal of molecular sciences 2023 Dec 5;24(24)
Advanced oxidation protein products induce Paneth cells defects by endoplasmic reticulum stress in Crohn's disease.
Shi J, Wang W, Sun S, Xu X, Fei J, Zhou Q, Qin C, Ou S, Wu F, Wu FT, Xu T, Bai L, Xie F
iScience 2023 Aug 18;26(8):107312
iScience 2023 Aug 18;26(8):107312
TOM complex-independent transport pathway of myoglobin into mitochondria in C2C12 myotubes.
Koma R, Shibaguchi T, Araiso Y, Yamada T, Nonaka Y, Jue T, Masuda K
Physiological reports 2023 Apr;11(7):e15632
Physiological reports 2023 Apr;11(7):e15632
Development of a Novel Circulating Autoantibody Biomarker Panel for the Identification of Patients with 'Actionable' Pulmonary Nodules.
Auger C, Moudgalya H, Neely MR, Stephan JT, Tarhoni I, Gerard D, Basu S, Fhied CL, Abdelkader A, Vargas M, Hu S, Hulett T, Liptay MJ, Shah P, Seder CW, Borgia JA
Cancers 2023 Apr 12;15(8)
Cancers 2023 Apr 12;15(8)
Disruption of mitochondria-associated ER membranes impairs insulin sensitivity and thermogenic function of adipocytes.
Wang CH, Wang CH, Hung PJ, Wei YH
Frontiers in cell and developmental biology 2022;10:965523
Frontiers in cell and developmental biology 2022;10:965523
AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology.
Tilokani L, Russell FM, Hamilton S, Virga DM, Segawa M, Paupe V, Gruszczyk AV, Protasoni M, Tabara LC, Johnson M, Anand H, Murphy MP, Hardie DG, Polleux F, Prudent J
Science advances 2022 Nov 11;8(45):eabo7956
Science advances 2022 Nov 11;8(45):eabo7956
GRP75-driven, cell-cycle-dependent macropinocytosis of Tat/pDNA-Ca(2+) nanoparticles underlies distinct gene therapy effect in ovarian cancer.
Su L, Sun Z, Qi F, Su H, Qian L, Li J, Zuo L, Huang J, Yu Z, Li J, Chen Z, Zhang S
Journal of nanobiotechnology 2022 Jul 20;20(1):340
Journal of nanobiotechnology 2022 Jul 20;20(1):340
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
Sun D, Niu Z, Zheng HX, Wu F, Jiang L, Han TQ, Wei Y, Wang J, Jin L
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15
Allosteric activation of Hsp70 reduces mutant huntingtin levels, the clustering of N-terminal fragments, and their nuclear accumulation.
Pinho BR, Almeida LM, Duchen MR, Oliveira JMA
Life sciences 2021 Nov 15;285:120009
Life sciences 2021 Nov 15;285:120009
LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding.
Shin CS, Meng S, Garbis SD, Moradian A, Taylor RW, Sweredoski MJ, Lomenick B, Chan DC
Nature communications 2021 Jan 11;12(1):265
Nature communications 2021 Jan 11;12(1):265
N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties.
Scott GK, Mahoney S, Scott M, Loureiro A, Lopez-Ramirez A, Tanner JJ, Ellerby LM, Benz CC
Amino acids 2021 Dec;53(12):1927-1939
Amino acids 2021 Dec;53(12):1927-1939
Mitochondrial DNA Haplogroup M7 Confers Disability in a Chinese Aging Population.
Sun D, Yao S, Wu F, Deng W, Ma Y, Jin L, Wang J, Wang X
Frontiers in genetics 2020;11:577795
Frontiers in genetics 2020;11:577795
ATF4 Mediates Mitochondrial Unfolded Protein Response in Alveolar Epithelial Cells.
Jiang D, Cui H, Xie N, Banerjee S, Liu RM, Dai H, Thannickal VJ, Liu G
American journal of respiratory cell and molecular biology 2020 Oct;63(4):478-489
American journal of respiratory cell and molecular biology 2020 Oct;63(4):478-489
TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response.
Wang P, Deng J, Dong J, Liu J, Bigio EH, Mesulam M, Wang T, Sun L, Wang L, Lee AY, McGee WA, Chen X, Fushimi K, Zhu L, Wu JY
PLoS genetics 2019 May;15(5):e1007947
PLoS genetics 2019 May;15(5):e1007947
Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology.
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Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.
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ABT737 reverses cisplatin resistance by regulating ER-mitochondria Ca2+ signal transduction in human ovarian cancer cells.
Xie Q, Su J, Jiao B, Shen L, Ma L, Qu X, Yu C, Jiang X, Xu Y, Sun L
International journal of oncology 2016 Dec;49(6):2507-2519
International journal of oncology 2016 Dec;49(6):2507-2519
DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling.
Richter-Dennerlein R, Korwitz A, Haag M, Tatsuta T, Dargazanli S, Baker M, Decker T, Lamkemeyer T, Rugarli EI, Langer T
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Upregulation of phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in acquired middle ear cholesteatoma growth.
Ho KY, Yeh TS, Huang HH, Hung KF, Chai CY, Chen WT, Tsai SM, Chang NC, Chien CY, Wang HM, Wu YJ
International journal of molecular sciences 2013 Jul 11;14(7):14439-59
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An investigation into the cytotoxic effects of 13-acetoxysarcocrassolide from the soft coral Sarcophyton crassocaule on bladder cancer cells.
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Marine drugs 2011 Dec;9(12):2622-2642
Marine drugs 2011 Dec;9(12):2622-2642
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 14887-1-AP(GRP75 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The GRP75 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human GRP75. This antibody recognizes human,mouse,rat antigen. The GRP75 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 14887-1-AP(GRP75 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 14887-1-AP(GRP75 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue