Antibody data
- Antibody Data
- Antigen structure
- References [41]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
- Flow cytometry [1]
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Validation data
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- Product number
- 17516-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17516-1-AP, RRID:AB_2133036
- Product name
- Cytokeratin 17-Specific antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Cytokeratin 17-Specific antibody (Cat. #17516-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Licoisoflavone B alleviates psoriasis via SCD1-targeted lipid metabolism reprogramming and suppression of Th17/IL-17-mediated inflammation.
The enhanced osteogenic differentiation of human periodontal ligament stem cells and M2 polarization of macrophages may be mediated by EphB4/ephrinB2 signaling pathway: a study of their direct co-culture.
A conserved re-epithelialization program underlies malignancy in pancreatic ductal adenocarcinoma.
Integrated transcriptome and proteome analysis identifies keratins as key regulators of corneal scarring in a murine model.
Tanshinone I Ameliorates Psoriasis-Like Dermatitis by Suppressing Inflammation and Regulating Keratinocyte Differentiation.
Smilax glabra Roxb. extract alleviates psoriasis-like lesions in mice by the synergistic effects of TOP2A inhibition and AhR activation.
Spatial Proteomic Analysis Highlights Molecular Reprogramming in Optic Nerve Invasive Retinoblastoma.
Morinda Officinalis-Derived Extracellular Vesicle-like Particles Promote Wound Healing via Angiogenesis.
Basal and AT2 cells promote IPF-lung cancer co-occurrence via EMT: Single-cell analysis.
Engineering a halloysite nanotube-enhanced hydrogel 3D skin model for modulated inflammation and accelerated wound healing.
Rapid angiogenic hydrogel nanofiber scaffold promotes random flap regeneration and modulates inflammation.
Butyrate Ameliorates Graves' Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota.
Epidermal Loss of PRMT5 Leads to the Emergence of an Atypical Basal Keratinocyte-Like Cell Population and Defective Epidermal Stratification.
Luminal hormone-responsive cells tune the regenerative remodeling of mammary glands in large mammals.
TNFSF14-HVEM/LTβR Exacerbates Keratinocyte Abnormalities and IMQ-Induced Psoriatic Skin Inflammation via Activating NF-κB/TWIST1 Signalling Pathway.
Targeted Delivery of CD34 Aptamer-Coupled Tocilizumab Microspheres for Effective Treatment of Thyroid-Associated Ophthalmopathy.
Evolutionary fingerprints of epithelial-to-mesenchymal transition.
Expression Distribution of Keratins in Normal and Pathological Corneas and the Regulatory Role of Krt17 on Limbal Stem Cells.
Multi-model analysis of gallbladder cancer reveals the role of OxLDL-absorbing neutrophils in promoting liver invasion.
Epigallocatechin-3-gallate promotes wound healing response in diabetic mice by activating keratinocytes and promoting re-epithelialization.
Tracing immune cells around biomaterials with spatial anchors during large-scale wound regeneration.
FGF4 Promotes Skin Wound Repair through p38 MAPK and GSK3β-Mediated Stabilization of Slug.
LncRNA NR120519 Blocks KRT17 to Promote Cell Proliferation and Migration in Hypopharyngeal Squamous Carcinoma.
Keratin 17 Impacts Global Gene Expression and Controls G2/M Cell Cycle Transition in Ionizing Radiation-Induced Skin Damage.
Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer.
Macrophages mediate psoriasis via Mincle-dependent mechanism in mice.
Effects of ambient PM(2.5) on development of psoriasiform inflammation through KRT17-dependent activation of AKT/mTOR/HIF-1α pathway.
APEX2-Mediated Proximity Labeling Resolves the DDIT4-Interacting Proteome.
The keratin 17/YAP/IL6 axis contributes to E-cadherin loss and aggressiveness of diffuse gastric cancer.
Botox-A improve the thyroid-associated ophthalmopathy (TAO) orbital fibroblast activation through inhibiting the TGF-β/Smad signaling.
Low Expression of Keratin17 is Related to Poor Prognosis in Bladder Cancer.
Keratin 17 upregulation promotes cell metastasis and angiogenesis in colon adenocarcinoma.
[Sitagliptin inhibits lipopolysaccharide-induced inflammatory response in human gingival fibroblasts by blocking nuclear factor-κB signaling pathway].
A Preclinical Trial and Molecularly Annotated Patient Cohort Identify Predictive Biomarkers in Homologous Recombination-deficient Pancreatic Cancer.
Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway.
Anillin regulates breast cancer cell migration, growth, and metastasis by non-canonical mechanisms involving control of cell stemness and differentiation.
The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model.
Overexpression of KRT17 promotes proliferation and invasion of non-small cell lung cancer and indicates poor prognosis.
Spatiotemporal immune zonation of the human kidney.
Cytokeratin expression in epidermal stem cells in skin adnexal tumors.
Keratin17 Promotes Tumor Growth and is Associated with Poor Prognosis in Gastric Cancer.
Liu Y, Wong VKW, Liu J, Jiang M, Yang C, He X, Wang J, Zhang L, Xiong A, Ran Q, Li X, Wang K, Li M, Song P, Jin L, Li G
Frontiers in pharmacology 2026;17:1754729
Frontiers in pharmacology 2026;17:1754729
The enhanced osteogenic differentiation of human periodontal ligament stem cells and M2 polarization of macrophages may be mediated by EphB4/ephrinB2 signaling pathway: a study of their direct co-culture.
Yang X, Luan Y, Qiu J, Ren H, Yin Q, Liu H, Song H, Song A
Stem cell research & therapy 2026 Mar 2;17(1)
Stem cell research & therapy 2026 Mar 2;17(1)
A conserved re-epithelialization program underlies malignancy in pancreatic ductal adenocarcinoma.
Zhuo M, Li Y, Zhang Y, Yang C, Zou D, Xu W, Han J, Wang S, Deng H, Pan X, Dun R, He R, Shi Y, Han X, Zhang T, Wang W, Dai M, Xu Q, Liu L, Wang W, Liu Y, Liu M, Deng Z, Zhao Y, Wu W, Peng J, Chen M, David CJ
Cancer cell 2026 Apr 30;
Cancer cell 2026 Apr 30;
Integrated transcriptome and proteome analysis identifies keratins as key regulators of corneal scarring in a murine model.
Zhou T, Cai Y, Fang F, Cai X, Fu Y
Computational and structural biotechnology journal 2025;27:2264-2274
Computational and structural biotechnology journal 2025;27:2264-2274
Tanshinone I Ameliorates Psoriasis-Like Dermatitis by Suppressing Inflammation and Regulating Keratinocyte Differentiation.
Wang Q, Luo X, Su Y, Jin Y, Kuang Q, Li S, Shen W, Zhu Y
Drug design, development and therapy 2025;19:539-552
Drug design, development and therapy 2025;19:539-552
Smilax glabra Roxb. extract alleviates psoriasis-like lesions in mice by the synergistic effects of TOP2A inhibition and AhR activation.
Wu X, Zhou H, Cheng G, Wang Y, Fu Y, Li S, Qin X
International immunopharmacology 2025 Oct 30;164:115408
International immunopharmacology 2025 Oct 30;164:115408
Spatial Proteomic Analysis Highlights Molecular Reprogramming in Optic Nerve Invasive Retinoblastoma.
Zhu T, Yang J, Xu M, He M, Liao Q, Shen Y, Luan Y, Wen X, Han M, Tong X, Yuan T, Ding X, Chai P, Fan J, Jia R
Investigative ophthalmology & visual science 2025 Oct 1;66(13):37
Investigative ophthalmology & visual science 2025 Oct 1;66(13):37
Morinda Officinalis-Derived Extracellular Vesicle-like Particles Promote Wound Healing via Angiogenesis.
Zhao Q, Hu QX, Li JP, Su HB, Li ZY, He J, You Q, Yang YL, Zhang HT, Zhao KW
ACS applied materials & interfaces 2025 May 28;17(21):30454-30464
ACS applied materials & interfaces 2025 May 28;17(21):30454-30464
Basal and AT2 cells promote IPF-lung cancer co-occurrence via EMT: Single-cell analysis.
Ren C, Zi Y, Zhang X, Liao X, Chen H
Experimental cell research 2025 May 15;448(2):114578
Experimental cell research 2025 May 15;448(2):114578
Engineering a halloysite nanotube-enhanced hydrogel 3D skin model for modulated inflammation and accelerated wound healing.
Xu R, Fu X, Lun L, Jiang W, Situ X, Huang X, Xiong Y, Liu C, Wang F
Bioactive materials 2025 Mar;45:148-161
Bioactive materials 2025 Mar;45:148-161
Rapid angiogenic hydrogel nanofiber scaffold promotes random flap regeneration and modulates inflammation.
Liang J, Zou Y, Ju H, Lv Y
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2025 Mar-Apr;33(2):e70028
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2025 Mar-Apr;33(2):e70028
Butyrate Ameliorates Graves' Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota.
Ouyang P, Qi J, Tong B, Li Y, Cao J, Wang L, Niu T, Qi X
Investigative ophthalmology & visual science 2025 Mar 3;66(3):5
Investigative ophthalmology & visual science 2025 Mar 3;66(3):5
Epidermal Loss of PRMT5 Leads to the Emergence of an Atypical Basal Keratinocyte-Like Cell Population and Defective Epidermal Stratification.
Recka N, Simons A, Cornell RA, Van Otterloo E
The Journal of investigative dermatology 2025 Dec;145(12):3100-3114.e14
The Journal of investigative dermatology 2025 Dec;145(12):3100-3114.e14
Luminal hormone-responsive cells tune the regenerative remodeling of mammary glands in large mammals.
Li Y, Zhang L, Luo T, Zhang W, Wang T, Liu F, Lin S, Luo J, Liu J, Peng J, Wang C, Wang W, Shi H
Cell discovery 2025 Dec 30;11(1):105
Cell discovery 2025 Dec 30;11(1):105
TNFSF14-HVEM/LTβR Exacerbates Keratinocyte Abnormalities and IMQ-Induced Psoriatic Skin Inflammation via Activating NF-κB/TWIST1 Signalling Pathway.
Long SJ, Zheng QY, Xu F, Li GQ, Chen J, Chen WJ, Xu JM, Gao XL, Liang SJ, Xu GL
Journal of cellular and molecular medicine 2025 Aug;29(15):e70774
Journal of cellular and molecular medicine 2025 Aug;29(15):e70774
Targeted Delivery of CD34 Aptamer-Coupled Tocilizumab Microspheres for Effective Treatment of Thyroid-Associated Ophthalmopathy.
Luo Y, Yin J, Cao J, Xie B, Zhang F, Ouyang S, Zhou J, Tan Y, Xiong W
Investigative ophthalmology & visual science 2025 Aug 1;66(11):57
Investigative ophthalmology & visual science 2025 Aug 1;66(11):57
Evolutionary fingerprints of epithelial-to-mesenchymal transition.
Perelli L, Zhang L, Mangiameli S, Giannese F, Mahadevan KK, Peng F, Citron F, Khan H, Le C, Gurreri E, Carbone F, Russell AJC, Soeung M, Lam TNA, Lundgren S, Marisetty S, Zhu C, Catania D, Mohamed AMT, Feng N, Augustine JJ, Sgambato A, Tortora G, Draetta GF, Tonon G, Futreal A, Giuliani V, Carugo A, Viale A, Kim MP, Heffernan TP, Wang L, Kalluri R, Cittaro D, Chen F, Genovese G
Nature 2025 Apr;640(8060):1083-1092
Nature 2025 Apr;640(8060):1083-1092
Expression Distribution of Keratins in Normal and Pathological Corneas and the Regulatory Role of Krt17 on Limbal Stem Cells.
Wang M, Chen R, Wang Y, Li Y, Zhou Q, Cao R, Li Y, Ge H, Wang X, Yang L
Investigative ophthalmology & visual science 2025 Apr 1;66(4):55
Investigative ophthalmology & visual science 2025 Apr 1;66(4):55
Multi-model analysis of gallbladder cancer reveals the role of OxLDL-absorbing neutrophils in promoting liver invasion.
Rao D, Li J, Zhang M, Huang S, Meng L, Song G, Ma J, Wu Y, Cheng Y, Ji S, Wu G, Chen L, Liu Y, Shi Y, Zhou J, Jia F, Zhang X, Xi R, Gao Q
Experimental hematology & oncology 2024 May 31;13(1):58
Experimental hematology & oncology 2024 May 31;13(1):58
Epigallocatechin-3-gallate promotes wound healing response in diabetic mice by activating keratinocytes and promoting re-epithelialization.
Ning Y, Yuan Z, Wang Q, He J, Zhu W, Ren DN, Wo D
Phytotherapy research : PTR 2024 Feb;38(2):1013-1027
Phytotherapy research : PTR 2024 Feb;38(2):1013-1027
Tracing immune cells around biomaterials with spatial anchors during large-scale wound regeneration.
Yang Y, Chu C, Liu L, Wang C, Hu C, Rung S, Man Y, Qu Y
Nature communications 2023 Sep 26;14(1):5995
Nature communications 2023 Sep 26;14(1):5995
FGF4 Promotes Skin Wound Repair through p38 MAPK and GSK3β-Mediated Stabilization of Slug.
Sun J, Zhou J, Zhou J, Xu W, Du Y, Jia Z, Shen Y, Lin X, Wang X, Bao Y, Rao Z, Dong S, Luo Y, Cong W, Jin L, Li X
The Journal of investigative dermatology 2023 Jun;143(6):1073-1084.e8
The Journal of investigative dermatology 2023 Jun;143(6):1073-1084.e8
LncRNA NR120519 Blocks KRT17 to Promote Cell Proliferation and Migration in Hypopharyngeal Squamous Carcinoma.
Zhou Z, Zhang G, Li T, Ai J, Li W, Zeng S, Ye M, Liu Q, Xiao J, Li Y, Tan G, Zhang X
Cancers 2023 Jan 18;15(3)
Cancers 2023 Jan 18;15(3)
Keratin 17 Impacts Global Gene Expression and Controls G2/M Cell Cycle Transition in Ionizing Radiation-Induced Skin Damage.
Yue Z, Lin J, Lu X, Gao Q, Pan M, Zhang Y, Shen S, Zhu WG, Paus R
The Journal of investigative dermatology 2023 Dec;143(12):2436-2446.e13
The Journal of investigative dermatology 2023 Dec;143(12):2436-2446.e13
Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer.
Liu X, Zhao S, Wang K, Zhou L, Jiang M, Gao Y, Yang R, Yan S, Zhang W, Lu B, Liu F, Zhao R, Liu W, Zhang Z, Liu K, Li X, Dong Z
Nature communications 2023 Aug 8;14(1):4779
Nature communications 2023 Aug 8;14(1):4779
Macrophages mediate psoriasis via Mincle-dependent mechanism in mice.
Tan RZ, Zhong X, Han RY, Xie KH, Jia J, Yang Y, Cheng M, Yang CY, Lan HY, Wang L
Cell death discovery 2023 Apr 28;9(1):140
Cell death discovery 2023 Apr 28;9(1):140
Effects of ambient PM(2.5) on development of psoriasiform inflammation through KRT17-dependent activation of AKT/mTOR/HIF-1α pathway.
Wang X, Niu L, Kang A, Pang Y, Zhang Y, Wang W, Zhang Y, Huang X, Liu Q, Geng Z, He L, Niu Y, Zhang R
Ecotoxicology and environmental safety 2022 Sep 15;243:114008
Ecotoxicology and environmental safety 2022 Sep 15;243:114008
APEX2-Mediated Proximity Labeling Resolves the DDIT4-Interacting Proteome.
Naki M, Gourdomichali O, Zonke K, Kattan FG, Makridakis M, Kontostathi G, Vlahou A, Doxakis E
International journal of molecular sciences 2022 May 6;23(9)
International journal of molecular sciences 2022 May 6;23(9)
The keratin 17/YAP/IL6 axis contributes to E-cadherin loss and aggressiveness of diffuse gastric cancer.
Li M, Rao X, Cui Y, Zhang L, Li X, Wang B, Zheng Y, Teng L, Zhou T, Zhuo W
Oncogene 2022 Feb;41(6):770-781
Oncogene 2022 Feb;41(6):770-781
Botox-A improve the thyroid-associated ophthalmopathy (TAO) orbital fibroblast activation through inhibiting the TGF-β/Smad signaling.
Qi X, Luo B, Deng M, Cao J, Hou S, Xie Z, Tong B, Xiong W
Experimental eye research 2022 Apr;217:108971
Experimental eye research 2022 Apr;217:108971
Low Expression of Keratin17 is Related to Poor Prognosis in Bladder Cancer.
Wu J, Xu H, Ji H, Zhai B, Zhu J, Gao M, Zhu H, Wang X
OncoTargets and therapy 2021;14:577-587
OncoTargets and therapy 2021;14:577-587
Keratin 17 upregulation promotes cell metastasis and angiogenesis in colon adenocarcinoma.
Ji R, Ji Y, Ma L, Ge S, Chen J, Wu S, Huang T, Sheng Y, Wang L, Yi N, Liu Z
Bioengineered 2021 Dec;12(2):12598-12611
Bioengineered 2021 Dec;12(2):12598-12611
[Sitagliptin inhibits lipopolysaccharide-induced inflammatory response in human gingival fibroblasts by blocking nuclear factor-κB signaling pathway].
Liu X, Kang WY, Shang LL, Ge SH
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 2021 Apr 1;39(2):153-163
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 2021 Apr 1;39(2):153-163
A Preclinical Trial and Molecularly Annotated Patient Cohort Identify Predictive Biomarkers in Homologous Recombination-deficient Pancreatic Cancer.
Wang Y, Park JYP, Pacis A, Denroche RE, Jang GH, Zhang A, Cuggia A, Domecq C, Monlong J, Raitses-Gurevich M, Grant RC, Borgida A, Holter S, Stossel C, Bu S, Masoomian M, Lungu IM, Bartlett JMS, Wilson JM, Gao ZH, Riazalhosseini Y, Asselah J, Bouganim N, Cabrera T, Boucher LM, Valenti D, Biagi J, Greenwood CMT, Polak P, Foulkes WD, Golan T, O'Kane GM, Fischer SE, Knox JJ, Gallinger S, Zogopoulos G
Clinical cancer research : an official journal of the American Association for Cancer Research 2020 Oct 15;26(20):5462-5476
Clinical cancer research : an official journal of the American Association for Cancer Research 2020 Oct 15;26(20):5462-5476
Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway.
Yan X, Yang C, Hu W, Chen T, Wang Q, Pan F, Qiu B, Tang B
Oncology reports 2020 Jul;44(1):103-114
Oncology reports 2020 Jul;44(1):103-114
Anillin regulates breast cancer cell migration, growth, and metastasis by non-canonical mechanisms involving control of cell stemness and differentiation.
Wang D, Naydenov NG, Dozmorov MG, Koblinski JE, Ivanov AI
Breast cancer research : BCR 2020 Jan 7;22(1):3
Breast cancer research : BCR 2020 Jan 7;22(1):3
The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model.
Wu S, Zhao M, Sun Y, Xie M, Le K, Xu M, Huang C
Life sciences 2020 Jan 15;241:117115
Life sciences 2020 Jan 15;241:117115
Overexpression of KRT17 promotes proliferation and invasion of non-small cell lung cancer and indicates poor prognosis.
Wang Z, Yang MQ, Lei L, Fei LR, Zheng YW, Huang WJ, Li ZH, Liu CC, Xu HT
Cancer management and research 2019;11:7485-7497
Cancer management and research 2019;11:7485-7497
Spatiotemporal immune zonation of the human kidney.
Stewart BJ, Ferdinand JR, Young MD, Mitchell TJ, Loudon KW, Riding AM, Richoz N, Frazer GL, Staniforth JUL, Vieira Braga FA, Botting RA, Popescu DM, Vento-Tormo R, Stephenson E, Cagan A, Farndon SJ, Polanski K, Efremova M, Green K, Del Castillo Velasco-Herrera M, Guzzo C, Collord G, Mamanova L, Aho T, Armitage JN, Riddick ACP, Mushtaq I, Farrell S, Rampling D, Nicholson J, Filby A, Burge J, Lisgo S, Lindsay S, Bajenoff M, Warren AY, Stewart GD, Sebire N, Coleman N, Haniffa M, Teichmann SA, Behjati S, Clatworthy MR
Science (New York, N.Y.) 2019 Sep 27;365(6460):1461-1466
Science (New York, N.Y.) 2019 Sep 27;365(6460):1461-1466
Cytokeratin expression in epidermal stem cells in skin adnexal tumors.
Zhou X, Li G, Wang D, Sun X, Li X
Oncology letters 2019 Jan;17(1):927-932
Oncology letters 2019 Jan;17(1):927-932
Keratin17 Promotes Tumor Growth and is Associated with Poor Prognosis in Gastric Cancer.
Hu H, Xu DH, Huang XX, Zhu CC, Xu J, Zhang ZZ, Zhao G
Journal of Cancer 2018;9(2):346-357
Journal of Cancer 2018;9(2):346-357
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- A431 cells were subjected to SDS PAGE followed by western blot with 17516-1-AP(KRT17-Specific antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunofluorescent analysis of Hela cells, using KRT17 antibody 17516-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 17516-1-AP(KRT17-Specific antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 17516-1-AP(KRT17-Specific antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The Cytokeratin 17-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human Cytokeratin 17-Specific. This antibody recognizes human,mouse,rat antigen. The Cytokeratin 17-Specific antibody has been validated for the following applications: ELISA, WB, IHC, IF, FC analysis.