17516-1-AP

antibody from Proteintech Group

Targeting: KRT17 PCHC1

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

17516-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#17516-1-AP, RRID:AB_2133036

Product name

Cytokeratin 17-Specific antibody

Antibody type

Polyclonal

Description

KD/KO validated Cytokeratin 17-Specific antibody (Cat. #17516-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Epigallocatechin-3-gallate promotes wound healing response in diabetic mice by activating keratinocytes and promoting re-epithelialization.

Ning Y, Yuan Z, Wang Q, He J, Zhu W, Ren DN, Wo D
Phytotherapy research : PTR 2024 Feb;38(2):1013-1027

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Tracing immune cells around biomaterials with spatial anchors during large-scale wound regeneration.

Yang Y, Chu C, Liu L, Wang C, Hu C, Rung S, Man Y, Qu Y
Nature communications 2023 Sep 26;14(1):5995

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FGF4 Promotes Skin Wound Repair through p38 MAPK and GSK3β-Mediated Stabilization of Slug.

Sun J, Zhou J, Zhou J, Xu W, Du Y, Jia Z, Shen Y, Lin X, Wang X, Bao Y, Rao Z, Dong S, Luo Y, Cong W, Jin L, Li X
The Journal of investigative dermatology 2023 Jun;143(6):1073-1084.e8

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LncRNA NR120519 Blocks KRT17 to Promote Cell Proliferation and Migration in Hypopharyngeal Squamous Carcinoma.

Zhou Z, Zhang G, Li T, Ai J, Li W, Zeng S, Ye M, Liu Q, Xiao J, Li Y, Tan G, Zhang X
Cancers 2023 Jan 18;15(3)

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Keratin 17 Impacts Global Gene Expression and Controls G2/M Cell Cycle Transition in Ionizing Radiation-Induced Skin Damage.

Yue Z, Lin J, Lu X, Gao Q, Pan M, Zhang Y, Shen S, Zhu WG, Paus R
The Journal of investigative dermatology 2023 Dec;143(12):2436-2446.e13

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Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer.

Liu X, Zhao S, Wang K, Zhou L, Jiang M, Gao Y, Yang R, Yan S, Zhang W, Lu B, Liu F, Zhao R, Liu W, Zhang Z, Liu K, Li X, Dong Z
Nature communications 2023 Aug 8;14(1):4779

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Macrophages mediate psoriasis via Mincle-dependent mechanism in mice.

Tan RZ, Zhong X, Han RY, Xie KH, Jia J, Yang Y, Cheng M, Yang CY, Lan HY, Wang L
Cell death discovery 2023 Apr 28;9(1):140

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Effects of ambient PM(2.5) on development of psoriasiform inflammation through KRT17-dependent activation of AKT/mTOR/HIF-1α pathway.

Wang X, Niu L, Kang A, Pang Y, Zhang Y, Wang W, Zhang Y, Huang X, Liu Q, Geng Z, He L, Niu Y, Zhang R
Ecotoxicology and environmental safety 2022 Sep 15;243:114008

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APEX2-Mediated Proximity Labeling Resolves the DDIT4-Interacting Proteome.

Naki M, Gourdomichali O, Zonke K, Kattan FG, Makridakis M, Kontostathi G, Vlahou A, Doxakis E
International journal of molecular sciences 2022 May 6;23(9)

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The keratin 17/YAP/IL6 axis contributes to E-cadherin loss and aggressiveness of diffuse gastric cancer.

Li M, Rao X, Cui Y, Zhang L, Li X, Wang B, Zheng Y, Teng L, Zhou T, Zhuo W
Oncogene 2022 Feb;41(6):770-781

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Botox-A improve the thyroid-associated ophthalmopathy (TAO) orbital fibroblast activation through inhibiting the TGF-β/Smad signaling.

Qi X, Luo B, Deng M, Cao J, Hou S, Xie Z, Tong B, Xiong W
Experimental eye research 2022 Apr;217:108971

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Low Expression of Keratin17 is Related to Poor Prognosis in Bladder Cancer.

Wu J, Xu H, Ji H, Zhai B, Zhu J, Gao M, Zhu H, Wang X
OncoTargets and therapy 2021;14:577-587

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Keratin 17 upregulation promotes cell metastasis and angiogenesis in colon adenocarcinoma.

Ji R, Ji Y, Ma L, Ge S, Chen J, Wu S, Huang T, Sheng Y, Wang L, Yi N, Liu Z
Bioengineered 2021 Dec;12(2):12598-12611

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[Sitagliptin inhibits lipopolysaccharide-induced inflammatory response in human gingival fibroblasts by blocking nuclear factor-κB signaling pathway].

Liu X, Kang WY, Shang LL, Ge SH
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 2021 Apr 1;39(2):153-163

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A Preclinical Trial and Molecularly Annotated Patient Cohort Identify Predictive Biomarkers in Homologous Recombination-deficient Pancreatic Cancer.

Wang Y, Park JYP, Pacis A, Denroche RE, Jang GH, Zhang A, Cuggia A, Domecq C, Monlong J, Raitses-Gurevich M, Grant RC, Borgida A, Holter S, Stossel C, Bu S, Masoomian M, Lungu IM, Bartlett JMS, Wilson JM, Gao ZH, Riazalhosseini Y, Asselah J, Bouganim N, Cabrera T, Boucher LM, Valenti D, Biagi J, Greenwood CMT, Polak P, Foulkes WD, Golan T, O'Kane GM, Fischer SE, Knox JJ, Gallinger S, Zogopoulos G
Clinical cancer research : an official journal of the American Association for Cancer Research 2020 Oct 15;26(20):5462-5476

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Anillin regulates breast cancer cell migration, growth, and metastasis by non-canonical mechanisms involving control of cell stemness and differentiation.

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Breast cancer research : BCR 2020 Jan 7;22(1):3

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The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model.

Wu S, Zhao M, Sun Y, Xie M, Le K, Xu M, Huang C
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Overexpression of KRT17 promotes proliferation and invasion of non-small cell lung cancer and indicates poor prognosis.

Wang Z, Yang MQ, Lei L, Fei LR, Zheng YW, Huang WJ, Li ZH, Liu CC, Xu HT
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Spatiotemporal immune zonation of the human kidney.

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Keratin17 Promotes Tumor Growth and is Associated with Poor Prognosis in Gastric Cancer.

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Journal of Cancer 2018;9(2):346-357

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

A431 cells were subjected to SDS PAGE followed by western blot with 17516-1-AP(KRT17-Specific antibody) at dilution of 1:300

Sample type

cell line

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of Hela cells, using KRT17 antibody 17516-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human cervical cancer using 17516-1-AP(KRT17-Specific antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human cervical cancer using 17516-1-AP(KRT17-Specific antibody) at dilution of 1:50 (under 40x lens)

Sample type

tissue

Flow cytometry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The Cytokeratin 17-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human Cytokeratin 17-Specific. This antibody recognizes human,mouse,rat antigen. The Cytokeratin 17-Specific antibody has been validated for the following applications: ELISA, WB, IHC, IF, FC analysis.

Appendix

17516-1-AP.pdf

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