Antibody data
- Antibody Data
- Antigen structure
- References [70]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 21180-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21180-1-AP, RRID:AB_10694573
- Product name
- S1PR2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated S1PR2 antibody (Cat. #21180-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Danlong oral liquid alleviates airway remodeling in asthma by targeting the S1PR2/ROCK1/YAP signaling pathway in airway smooth muscle cells.
Fractional carbon dioxide laser-induced photothermal activation of mesenchymal stem cell-derived exosomes accelerates diabetic wound healing by enhancing angiogenesis.
S1P2 Reduces Mast Cell Activation and Colonic Inflammation of L-Arginine-Induced Acute Pancreatitis.
Vitamin D(3) Metabolite-Enhanced Hepatic VDR-FXR Binding Attenuates Bile Acid Dysregulation-Induced Diarrhea in Weaned Piglets.
Hyperammonemia increases the release of pathological extracellular vesicles from monocytes by impairing lysosomal function and autophagy through the TNFα-cAMP-PKA-LC3 pathway.
Mitophagy-mediated S1P facilitates muscle adaptive responses to endurance exercise through SPHK1-S1PR1/S1PR2 in slow-twitch myofibers.
TGR5 dysfunction underlies chronic social defeat stress via cAMP/PKA signaling pathway in the hippocampus.
S1PR2-miR-212 feedback loop regulates allergic reactions.
The novel sphingosine-1-phosphate receptor modulator KRP-203 prevents myocardial ischemia-reperfusion injury by preserving mitochondrial function through activation of the RISK and SAFE signaling pathways.
Chaihu Guizhi Ganjiang Decoction ameliorates chronic pancreatitis by modulating the SK1/S1P signaling pathway.
Extracellular vesicles from Lacticaseibacillus paracasei reduce neuroinflammation in hippocampus and restore some cognitive functions in hyperammonemic rats.
S1PR3 inhibition impairs cell cycle checkpoint via the AKT/WEE1 pathway in oral squamous cell carcinoma.
Extracellular vesicles from mesenchymal stem cells improve liver injury in rats with mild liver damage. Underlying mechanisms and role of TGFβ.
S1PR2 Mediates Smooth Muscle Cell Proliferation and Endothelial Cell Permeability via Akt/mTOR and RhoA/ROCK1 in Atherosclerosis.
Extracellular Vesicles from Peripheral Blood Mononuclear Cells of Hyperammonemic Rats Induce Neuroinflammation in Hippocampus, Impairing Memory and Learning in Normal Rats.
The sphingosine-1-phosphate receptor 2 S1PR2 mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia.
The new anti-angiogenesis perspective of rheumatoid arthritis with geniposide: Reducing the extracellular release of HSP70 in HUVECs.
Fibrotic collagen-targeted delivery system blocks pancreatic intercellular crosstalk to alleviate pancreatic fibrosis.
Hydroxyl safflower yellow A regulates bone-fat balance in osteoporosis by SphK1/S1P/S1PR signaling pathway.
Overexpression of endothelial S1pr2 promotes blood-brain barrier disruption via JNK/c-Jun/MMP-9 pathway after traumatic brain injury in both in vivo and in vitro models.
Exogenous S1P via S1P receptor 2 induces CTGF expression through Src-RhoA-ROCK-YAP pathway in hepatic stellate cells.
Plantaginis semen ameliorates diabetic kidney disease via targeting the sphingosine kinase 1/sphingosine-1-phosphate pathway.
Targeting SNAI1-Mediated Colorectal Cancer Chemoresistance and Stemness by Sphingosine Kinase 2 Inhibition.
VSV infection and LPS treatment alter serum bile acid profiles, bile acid biosynthesis, and bile acid receptors in mice.
Pharmacodynamics and mechanism of Erigeron breviscapus granules in the treatment of ischemic stroke in mice by regulating sphingolipid metabolism based on metabolomics.
SPHK1/S1P/S1PR pathway promotes the progression of peritoneal fibrosis by mesothelial-mesenchymal transition.
Altered sphingolipid pathway in SARS-CoV-2 infected human lung tissue.
S1PR2/Wnt3a/RhoA/ROCK1/β-catenin signaling pathway promotes diabetic nephropathy by inducting endothelial mesenchymal transition and impairing endothelial barrier function.
Estrogen increases the expression of BKCa and impairs the contraction of colon smooth muscle via upregulation of sphingosine kinase 1.
Liver sinusoidal endothelial S1pr2 regulates experimental liver fibrosis through YAP/TGF-β signaling pathway.
Skeletal muscle insulin resistance and adipose tissue hypertrophy persist beyond the reshaping of gut microbiota in young rats fed a fructose-rich diet.
Sphingosine 1-phosphate receptor 2 promotes the onset and progression of non-alcoholic fatty liver disease-related hepatocellular carcinoma through the PI3K/AKT/mTOR pathway.
Pancreatic Acinar Cells-Derived Sphingosine-1-Phosphate Contributes to Fibrosis of Chronic Pancreatitis via Inducing Autophagy and Activation of Pancreatic Stellate Cells.
Enhanced Activation of the S1PR2-IL-1β-Src-BDNF-TrkB Pathway Mediates Neuroinflammation in the Hippocampus and Cognitive Impairment in Hyperammonemic Rats.
Sphingosine 1-phosphate elicits a ROS-mediated proinflammatory response in human endometrial stromal cells via ERK5 activation.
Sphingosine 1-phosphate receptor 1 regulates blood-brain barrier permeability in epileptic mice.
S1P/S1PR2 promote pancreatic stellate cell activation and pancreatic fibrosis in chronic pancreatitis by regulating autophagy and the NLRP3 inflammasome.
Endothelial S1pr2 regulates post-ischemic angiogenesis via AKT/eNOS signaling pathway.
circSSU72 Promotes Cell Proliferation, Migration and Invasion of Papillary Thyroid Carcinoma Cells by Targeting miR-451a/S1PR2 Axis.
Sphingosine 1-phosphate receptor 2 promotes erythrocyte clearance by vascular smooth muscle cells in intraplaque hemorrhage through MFG-E8 production.
The function of Sphingosine-1-phosphate receptor 2 (S1PR2) in maintaining intestinal barrier and inducing ulcerative colitis.
Ameliorative effect of Gastrodia elata Blume extracts on depression in zebrafish and cellular models through modulating reticulon 4 receptors and apoptosis.
YAP signaling in horizontal basal cells promotes the regeneration of olfactory epithelium after injury.
S1PR2/RhoA/ROCK1 pathway promotes inflammatory bowel disease by inducing intestinal vascular endothelial barrier damage and M1 macrophage polarization.
Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways.
Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis.
Protective Effects of Complement Component 8 Gamma Against Blood-Brain Barrier Breakdown.
Therapeutic development of group B Streptococcus meningitis by targeting a host cell signaling network involving EGFR.
Gamma subunit of complement component 8 is a neuroinflammation inhibitor.
Effects of S1PR2 antagonist on blood pressure and angiogenesis imbalance in preeclampsia rats.
Sphingosine 1-phosphate signaling in uterine fibroids: implication in activin A pro-fibrotic effect.
Nogo-A regulates myogenesis via interacting with Filamin-C.
Knockdown of long non‑coding RNA ANRIL inhibits the proliferation and promotes the apoptosis of Burkitt lymphoma cells through the TGF‑β1 signaling pathway.
Raw and wine processed Schisandra chinensis attenuate anxiety like behavior via modulating gut microbiota and lipid metabolism pathway.
Inhibition of sphingosine 1-phosphate (S1P) receptor 1/2/3 ameliorates biological dysfunction in rheumatoid arthritis fibroblast-like synoviocyte MH7A cells through Gαi/Gαs rebalancing.
Sphingosine 1-phosphate promotes the proliferation of olfactory ensheathing cells through YAP signaling and participates in the formation of olfactory nerve layer.
Targeting E. coli invasion of the blood-brain barrier for investigating the pathogenesis and therapeutic development of E. coli meningitis.
JTE-013 supplementation improves erectile dysfunction in rats with streptozotocin-induced type Ⅰ diabetes through the inhibition of the rho-kinase pathway, fibrosis, and apoptosis.
Gut microbiome-derived lactate promotes to anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway.
Up-regulation of sphingosine-1-phosphate receptors and sphingosine kinase 1 in the peri-ischemic area after transient middle cerebral artery occlusion in mice.
β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P(2) modulation.
Bile acids increase steroidogenesis in cholemic mice and induce cortisol secretion in adrenocortical H295R cells via S1PR2, ERK and SF-1.
S1P promotes inflammation-induced tube formation by HLECs via the S1PR1/NF-κB pathway.
Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2.
Androgen deficiency impairs erectile function in rats through promotion of corporal fibrosis.
14-3-3ζ promotes esophageal squamous cell carcinoma invasion by repressing S1PR2 protein expression through NF-κB signaling.
S1PR2 antagonist protects endothelial cells against high glucose-induced mitochondrial apoptosis through the Akt/GSK-3β signaling pathway.
S1PR2 variants associated with auditory function in humans and endocochlear potential decline in mouse.
Sphingosine-1-phosphate mediates AKT/ERK maintenance of dental pulp homoeostasis.
Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke.
Zhou M, Xiang M, Li Y, Wang Z, Lin J
Journal of ethnopharmacology 2026 May 10;362:121347
Journal of ethnopharmacology 2026 May 10;362:121347
Fractional carbon dioxide laser-induced photothermal activation of mesenchymal stem cell-derived exosomes accelerates diabetic wound healing by enhancing angiogenesis.
Chen JY, Ji Z, Guo K, Wang HN, Zhu CC, Li T, Zhao XB, Wang YT, Li Q, Jin PS, Li XY
World journal of diabetes 2026 Jan 15;17(1):112942
World journal of diabetes 2026 Jan 15;17(1):112942
S1P2 Reduces Mast Cell Activation and Colonic Inflammation of L-Arginine-Induced Acute Pancreatitis.
Zhang R, Zhu J, Qu S, Chen X, Wang Y, Sun L, Zhang X, Lu Z, Wang X
Digestive diseases and sciences 2026 Feb 17;
Digestive diseases and sciences 2026 Feb 17;
Vitamin D(3) Metabolite-Enhanced Hepatic VDR-FXR Binding Attenuates Bile Acid Dysregulation-Induced Diarrhea in Weaned Piglets.
He L, Wu J, Wang Y, Jiao Y, Zhang F, Lin Z, Liu Q, Feng Y
Journal of agricultural and food chemistry 2026 Apr 22;74(15):12069-12086
Journal of agricultural and food chemistry 2026 Apr 22;74(15):12069-12086
Hyperammonemia increases the release of pathological extracellular vesicles from monocytes by impairing lysosomal function and autophagy through the TNFα-cAMP-PKA-LC3 pathway.
Pedrosa MA, Izquierdo-Altarejos P, Llansola M, Felipo V
Frontiers in immunology 2025;16:1724800
Frontiers in immunology 2025;16:1724800
Mitophagy-mediated S1P facilitates muscle adaptive responses to endurance exercise through SPHK1-S1PR1/S1PR2 in slow-twitch myofibers.
Leng M, Yang F, Zhao J, Xiong Y, Zhou Y, Zhao M, Jia S, Liu L, Zheng Q, Gan L, Ye J, Zheng M
Autophagy 2025 Oct;21(10):2111-2129
Autophagy 2025 Oct;21(10):2111-2129
TGR5 dysfunction underlies chronic social defeat stress via cAMP/PKA signaling pathway in the hippocampus.
Chen X, Zhou Q, He Y, Wang Y, Jiang Y, Ren Y, Ren Y, Cai J, Yu H, Chen C, Cheng K, Xie P
Translational psychiatry 2025 Oct 6;15(1):366
Translational psychiatry 2025 Oct 6;15(1):366
S1PR2-miR-212 feedback loop regulates allergic reactions.
Jeoung J, Jo H, Kim W, Jeoung D
Molecular immunology 2025 Nov;187:166-177
Molecular immunology 2025 Nov;187:166-177
The novel sphingosine-1-phosphate receptor modulator KRP-203 prevents myocardial ischemia-reperfusion injury by preserving mitochondrial function through activation of the RISK and SAFE signaling pathways.
Wu N, Wang L, Yu S, Wei X, Xu H, Xu S, Jia P, Zhang X
Cell biology and toxicology 2025 Nov 27;41(1):159
Cell biology and toxicology 2025 Nov 27;41(1):159
Chaihu Guizhi Ganjiang Decoction ameliorates chronic pancreatitis by modulating the SK1/S1P signaling pathway.
Yao GW, Li CX, Fan YX, Zhuo YZ, Zhang SK, Cui LH
Journal of natural medicines 2025 May;79(3):706-720
Journal of natural medicines 2025 May;79(3):706-720
Extracellular vesicles from Lacticaseibacillus paracasei reduce neuroinflammation in hippocampus and restore some cognitive functions in hyperammonemic rats.
Izquierdo-Altarejos P, Arenas YM, Montoliu C, Pérez-Martínez G, Llansola M, Felipo V
Microbiological research 2025 May;294:128101
Microbiological research 2025 May;294:128101
S1PR3 inhibition impairs cell cycle checkpoint via the AKT/WEE1 pathway in oral squamous cell carcinoma.
Zhou X, Liu J, Chen X, Zhou X, Xu B, Gan G, Chen F
Journal of translational medicine 2025 May 23;23(1):573
Journal of translational medicine 2025 May 23;23(1):573
Extracellular vesicles from mesenchymal stem cells improve liver injury in rats with mild liver damage. Underlying mechanisms and role of TGFβ.
Mincheva G, Moreno-Manzano V, Felipo V, Llansola M
Life sciences 2025 Mar 1;364:123429
Life sciences 2025 Mar 1;364:123429
S1PR2 Mediates Smooth Muscle Cell Proliferation and Endothelial Cell Permeability via Akt/mTOR and RhoA/ROCK1 in Atherosclerosis.
Ouyang J, Long H, Chen S, Xiang H, Shu Z, Wang X, Zhang J, Liu H, Tang B, Xiao J, Liu Q, Zhan Z, Chen R, Lu H
Journal of biochemical and molecular toxicology 2025 Jun;39(6):e70351
Journal of biochemical and molecular toxicology 2025 Jun;39(6):e70351
Extracellular Vesicles from Peripheral Blood Mononuclear Cells of Hyperammonemic Rats Induce Neuroinflammation in Hippocampus, Impairing Memory and Learning in Normal Rats.
Izquierdo-Altarejos P, López-Gramaje A, Pedrosa MA, Sebestyén VE, Vazquez L, Martinez-Garcia M, Llansola M, Felipo V
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Jun 7;20(1):65
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Jun 7;20(1):65
The sphingosine-1-phosphate receptor 2 S1PR2 mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia.
Chang M, Zhao M, Whang EM, Lee RA, Scott DK, Wang JC
The Journal of biological chemistry 2025 Jul;301(7):110353
The Journal of biological chemistry 2025 Jul;301(7):110353
The new anti-angiogenesis perspective of rheumatoid arthritis with geniposide: Reducing the extracellular release of HSP70 in HUVECs.
Wei Y, Li Y, Shu Y, Gan PR, Zhu YL, Xu J, Jiang XM, Xia SL, Wang Y, Wu H
International immunopharmacology 2025 Jan 10;144:113645
International immunopharmacology 2025 Jan 10;144:113645
Fibrotic collagen-targeted delivery system blocks pancreatic intercellular crosstalk to alleviate pancreatic fibrosis.
Wang H, Qi L, Fang YF, Liu Y, Ye Z, Chen BT, Wang Y, Jiang HL, Li L
Journal of controlled release : official journal of the Controlled Release Society 2025 Dec 10;388(Pt 1):114278
Journal of controlled release : official journal of the Controlled Release Society 2025 Dec 10;388(Pt 1):114278
Hydroxyl safflower yellow A regulates bone-fat balance in osteoporosis by SphK1/S1P/S1PR signaling pathway.
Xu X, Hu X, Zhou S, Liu J, Su Z, Zheng Z, Luo D
Biochemical pharmacology 2025 Aug 20;242(Pt 1):117258
Biochemical pharmacology 2025 Aug 20;242(Pt 1):117258
Overexpression of endothelial S1pr2 promotes blood-brain barrier disruption via JNK/c-Jun/MMP-9 pathway after traumatic brain injury in both in vivo and in vitro models.
Cheng H, Men Y, An Y, Yu J, Zhang G, Li J, Wang X, Sun G, Wu Y
Frontiers in pharmacology 2024;15:1448570
Frontiers in pharmacology 2024;15:1448570
Exogenous S1P via S1P receptor 2 induces CTGF expression through Src-RhoA-ROCK-YAP pathway in hepatic stellate cells.
Park S, Kim J, Yang S, Kang SH, Kang W, Paik YH
Molecular biology reports 2024 Sep 2;51(1):950
Molecular biology reports 2024 Sep 2;51(1):950
Plantaginis semen ameliorates diabetic kidney disease via targeting the sphingosine kinase 1/sphingosine-1-phosphate pathway.
Lan JP, Xue YF, Pu JY, Ding Y, Gan ZY, Yang YB, Wang ZT, Jie XL, Yang L
Journal of ethnopharmacology 2024 Sep 15;331:118221
Journal of ethnopharmacology 2024 Sep 15;331:118221
Targeting SNAI1-Mediated Colorectal Cancer Chemoresistance and Stemness by Sphingosine Kinase 2 Inhibition.
Janakiraman H, Gao Z, Zhu Y, Dong J, Becker SA, Janneh A, Ogretmen B, Camp ER
World journal of oncology 2024 Oct;15(5):744-757
World journal of oncology 2024 Oct;15(5):744-757
VSV infection and LPS treatment alter serum bile acid profiles, bile acid biosynthesis, and bile acid receptors in mice.
Li Y, Luo Y, Wang C, Xu L, Dai X, An Y, He L, Zeng D, Bai Y, Zhang H
Microbiology spectrum 2024 Nov 5;12(11):e0083624
Microbiology spectrum 2024 Nov 5;12(11):e0083624
Pharmacodynamics and mechanism of Erigeron breviscapus granules in the treatment of ischemic stroke in mice by regulating sphingolipid metabolism based on metabolomics.
Liu C, Liu K, Tao X, Li W, Zhao S, Dai Q, Yao H, Mu F, Chen S, Li J, Dong T, Duan J, Wei P, Gao F, Xi M
Journal of pharmaceutical and biomedical analysis 2024 May 15;242:116058
Journal of pharmaceutical and biomedical analysis 2024 May 15;242:116058
SPHK1/S1P/S1PR pathway promotes the progression of peritoneal fibrosis by mesothelial-mesenchymal transition.
Zhao T, Ding T, Sun Z, Shao X, Li S, Lu H, Yuan JH, Guo Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23417
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23417
Altered sphingolipid pathway in SARS-CoV-2 infected human lung tissue.
Khan RJ, Single SL, Simmons CS, Athar M, Liu Y, Bodduluri S, Benson PV, Goliwas KF, Deshane JS
Frontiers in immunology 2023;14:1216278
Frontiers in immunology 2023;14:1216278
S1PR2/Wnt3a/RhoA/ROCK1/β-catenin signaling pathway promotes diabetic nephropathy by inducting endothelial mesenchymal transition and impairing endothelial barrier function.
Zhang J, Chen S, Xiang H, Xiao J, Zhao S, Shu Z, Chai Y, Ouyang J, Liu H, Wang X, Quan Q, Fan J, Gao P, Chen AF, Lu H
Life sciences 2023 Sep 1;328:121853
Life sciences 2023 Sep 1;328:121853
Estrogen increases the expression of BKCa and impairs the contraction of colon smooth muscle via upregulation of sphingosine kinase 1.
Wang Y, Jiang Y, Jiang L, Xiong W, Wang Y, Gao X, Chen Q, Lin L, Yu T, Tang Y
Journal of cellular physiology 2023 Oct;238(10):2390-2406
Journal of cellular physiology 2023 Oct;238(10):2390-2406
Liver sinusoidal endothelial S1pr2 regulates experimental liver fibrosis through YAP/TGF-β signaling pathway.
Liao Y, Zhou C, Duan Y, Liu X, Yue J, Li X, Wu J, Wan C, Zhang L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 May;37(5):e22905
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 May;37(5):e22905
Skeletal muscle insulin resistance and adipose tissue hypertrophy persist beyond the reshaping of gut microbiota in young rats fed a fructose-rich diet.
Mazzoli A, Porzio AD, Gatto C, Crescenzo R, Nazzaro M, Spagnuolo MS, Baccigalupi L, Ricca E, Amoresano A, Fontanarosa C, Bernacchioni C, Donati C, Iossa S, Cigliano L
The Journal of nutritional biochemistry 2023 Mar;113:109247
The Journal of nutritional biochemistry 2023 Mar;113:109247
Sphingosine 1-phosphate receptor 2 promotes the onset and progression of non-alcoholic fatty liver disease-related hepatocellular carcinoma through the PI3K/AKT/mTOR pathway.
Wang G, Zhang X, Zhou Z, Song C, Jin W, Zhang H, Wu W, Yi Y, Cui H, Zhang P, Liu X, Xu W, Shen X, Shen W, Wang X
Discover oncology 2023 Jan 11;14(1):4
Discover oncology 2023 Jan 11;14(1):4
Pancreatic Acinar Cells-Derived Sphingosine-1-Phosphate Contributes to Fibrosis of Chronic Pancreatitis via Inducing Autophagy and Activation of Pancreatic Stellate Cells.
Wang D, Han S, Lv G, Hu Y, Zhuo W, Zeng Z, Tang J, Huang Y, Wang F, Wang J, Zhao Y, Zhao G
Gastroenterology 2023 Dec;165(6):1488-1504.e20
Gastroenterology 2023 Dec;165(6):1488-1504.e20
Enhanced Activation of the S1PR2-IL-1β-Src-BDNF-TrkB Pathway Mediates Neuroinflammation in the Hippocampus and Cognitive Impairment in Hyperammonemic Rats.
Sancho-Alonso M, Arenas YM, Izquierdo-Altarejos P, Martinez-Garcia M, Llansola M, Felipo V
International journal of molecular sciences 2023 Dec 8;24(24)
International journal of molecular sciences 2023 Dec 8;24(24)
Sphingosine 1-phosphate elicits a ROS-mediated proinflammatory response in human endometrial stromal cells via ERK5 activation.
Seidita I, Tusa I, Prisinzano M, Menconi A, Cencetti F, Vannuccini S, Castiglione F, Bruni P, Petraglia F, Bernacchioni C, Rovida E, Donati C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Aug;37(8):e23061
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Aug;37(8):e23061
Sphingosine 1-phosphate receptor 1 regulates blood-brain barrier permeability in epileptic mice.
Yang LX, Yao YY, Yang JR, Cheng HL, Zhu XJ, Zhang ZJ
Neural regeneration research 2023 Aug;18(8):1763-1769
Neural regeneration research 2023 Aug;18(8):1763-1769
S1P/S1PR2 promote pancreatic stellate cell activation and pancreatic fibrosis in chronic pancreatitis by regulating autophagy and the NLRP3 inflammasome.
Cui L, Li C, Zhang G, Zhang L, Yao G, Zhuo Y, Cui N, Zhang S
Chemico-biological interactions 2023 Aug 1;380:110541
Chemico-biological interactions 2023 Aug 1;380:110541
Endothelial S1pr2 regulates post-ischemic angiogenesis via AKT/eNOS signaling pathway.
Zhou C, Kuang Y, Li Q, Duan Y, Liu X, Yue J, Chen X, Liu J, Zhang Y, Zhang L
Theranostics 2022;12(11):5172-5188
Theranostics 2022;12(11):5172-5188
circSSU72 Promotes Cell Proliferation, Migration and Invasion of Papillary Thyroid Carcinoma Cells by Targeting miR-451a/S1PR2 Axis.
Zhang Z, Xia F, Yao L, Jiang B, Li X
Frontiers in cell and developmental biology 2022;10:817028
Frontiers in cell and developmental biology 2022;10:817028
Sphingosine 1-phosphate receptor 2 promotes erythrocyte clearance by vascular smooth muscle cells in intraplaque hemorrhage through MFG-E8 production.
Pan D, Wu W, Zuo G, Xie X, Li H, Ren X, Kong C, Zhou W, Zhang Z, Waterfall M, Chen S
Cellular signalling 2022 Oct;98:110419
Cellular signalling 2022 Oct;98:110419
The function of Sphingosine-1-phosphate receptor 2 (S1PR2) in maintaining intestinal barrier and inducing ulcerative colitis.
Chen T, Gu K, Lin R, Liu Y, Shan Y
Bioengineered 2022 May;13(5):13703-13717
Bioengineered 2022 May;13(5):13703-13717
Ameliorative effect of Gastrodia elata Blume extracts on depression in zebrafish and cellular models through modulating reticulon 4 receptors and apoptosis.
Wang R, Ren Q, Gao D, Paudel YN, Li X, Wang L, Zhang P, Wang B, Shang X, Jin M
Journal of ethnopharmacology 2022 May 10;289:115018
Journal of ethnopharmacology 2022 May 10;289:115018
YAP signaling in horizontal basal cells promotes the regeneration of olfactory epithelium after injury.
Wu Q, Xu X, Miao X, Bao X, Li X, Xiang L, Wang W, Du S, Lu Y, Wang X, Yang D, Zhang J, Shen X, Li F, Lu S, Fan Y, Xu S, Chen Z, Wang Y, Teng H, Huang Z
Stem cell reports 2022 Mar 8;17(3):664-677
Stem cell reports 2022 Mar 8;17(3):664-677
S1PR2/RhoA/ROCK1 pathway promotes inflammatory bowel disease by inducing intestinal vascular endothelial barrier damage and M1 macrophage polarization.
Wang X, Chen S, Xiang H, Wang X, Xiao J, Zhao S, Shu Z, Ouyang J, Liang Z, Deng M, Chen X, Zhang J, Liu H, Quan Q, Gao P, Fan J, Chen AF, Lu H
Biochemical pharmacology 2022 Jul;201:115077
Biochemical pharmacology 2022 Jul;201:115077
Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways.
Liu K, Sun T, Luan Y, Chen Y, Song J, Ling L, Yuan P, Li R, Cui K, Ruan Y, Lan R, Wang T, Wang S, Liu J, Rao K
Andrology 2022 Feb;10(2):404-418
Andrology 2022 Feb;10(2):404-418
Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis.
Janneh AH, Kassir MF, Atilgan FC, Lee HG, Sheridan M, Oleinik N, Szulc Z, Voelkel-Johnson C, Nguyen H, Li H, Peterson YK, Marangoni E, Saatci O, Sahin O, Lilly M, Atkinson C, Tomlinson S, Mehrotra S, Ogretmen B
Cell reports 2022 Dec 6;41(10):111742
Cell reports 2022 Dec 6;41(10):111742
Protective Effects of Complement Component 8 Gamma Against Blood-Brain Barrier Breakdown.
Kim JH, Han J, Suk K
Frontiers in physiology 2021;12:671250
Frontiers in physiology 2021;12:671250
Therapeutic development of group B Streptococcus meningitis by targeting a host cell signaling network involving EGFR.
Zhu N, Zhang C, Prakash A, Hou Z, Liu W, She W, Morris A, Sik Kim K
EMBO molecular medicine 2021 Mar 5;13(3):e12651
EMBO molecular medicine 2021 Mar 5;13(3):e12651
Gamma subunit of complement component 8 is a neuroinflammation inhibitor.
Kim JH, Afridi R, Han J, Jung HG, Kim SC, Hwang EM, Shim HS, Ryu H, Choe Y, Hoe HS, Suk K
Brain : a journal of neurology 2021 Mar 3;144(2):528-552
Brain : a journal of neurology 2021 Mar 3;144(2):528-552
Effects of S1PR2 antagonist on blood pressure and angiogenesis imbalance in preeclampsia rats.
Zhang T, Guo D, Zheng W, Dai Q
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
Sphingosine 1-phosphate signaling in uterine fibroids: implication in activin A pro-fibrotic effect.
Bernacchioni C, Ciarmela P, Vannuzzi V, Greco S, Vannuccini S, Malentacchi F, Pellegrino P, Capezzuoli T, Sorbi F, Cencetti F, Bruni P, Donati C, Petraglia F
Fertility and sterility 2021 Jun;115(6):1576-1585
Fertility and sterility 2021 Jun;115(6):1576-1585
Nogo-A regulates myogenesis via interacting with Filamin-C.
Park S, Park JH, Kang UB, Choi SK, Elfadl A, Ullah HMA, Chung MJ, Son JY, Yun HH, Park JM, Yim JH, Jung SJ, Kim SH, Choi YC, Kim DS, Shin JH, Park JS, Hur K, Lee SH, Lee EJ, Hwang D, Jeong KS
Cell death discovery 2021 Jan 6;7(1):1
Cell death discovery 2021 Jan 6;7(1):1
Knockdown of long non‑coding RNA ANRIL inhibits the proliferation and promotes the apoptosis of Burkitt lymphoma cells through the TGF‑β1 signaling pathway.
Mao S, Jin J, Li Z, Yang W
Molecular medicine reports 2021 Feb;23(2)
Molecular medicine reports 2021 Feb;23(2)
Raw and wine processed Schisandra chinensis attenuate anxiety like behavior via modulating gut microbiota and lipid metabolism pathway.
Song Y, Shan B, Zeng S, Zhang J, Jin C, Liao Z, Wang T, Zeng Q, He H, Wei F, Ai Z, Su D
Journal of ethnopharmacology 2021 Feb 10;266:113426
Journal of ethnopharmacology 2021 Feb 10;266:113426
Inhibition of sphingosine 1-phosphate (S1P) receptor 1/2/3 ameliorates biological dysfunction in rheumatoid arthritis fibroblast-like synoviocyte MH7A cells through Gαi/Gαs rebalancing.
Wang M, Wu H, Wang R, Dai X, Deng R, Wang Y, Bu Y, Sun M, Zhang H
Clinical and experimental pharmacology & physiology 2021 Aug;48(8):1080-1089
Clinical and experimental pharmacology & physiology 2021 Aug;48(8):1080-1089
Sphingosine 1-phosphate promotes the proliferation of olfactory ensheathing cells through YAP signaling and participates in the formation of olfactory nerve layer.
Bao X, Xu X, Wu Q, Zhang J, Feng W, Yang D, Li F, Lu S, Liu H, Shen X, Zhang F, Xie C, Wu S, Lv Z, Wang W, Li H, Fang Y, Wang Y, Teng H, Huang Z
Glia 2020 Sep;68(9):1757-1774
Glia 2020 Sep;68(9):1757-1774
Targeting E. coli invasion of the blood-brain barrier for investigating the pathogenesis and therapeutic development of E. coli meningitis.
Zhu N, Liu W, Prakash A, Zhang C, Kim KS
Cellular microbiology 2020 Oct;22(10):e13231
Cellular microbiology 2020 Oct;22(10):e13231
JTE-013 supplementation improves erectile dysfunction in rats with streptozotocin-induced type Ⅰ diabetes through the inhibition of the rho-kinase pathway, fibrosis, and apoptosis.
Liu K, Cui K, Feng H, Li R, Lin H, Chen Y, Zhang Y, Chen Z, Yuan H, Li M, Wang T, Lan R, Liu J, Rao K, Wen B
Andrology 2020 Mar;8(2):497-508
Andrology 2020 Mar;8(2):497-508
Gut microbiome-derived lactate promotes to anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway.
Shan B, Ai Z, Zeng S, Song Y, Song J, Zeng Q, Liao Z, Wang T, Huang C, Su D
Psychoneuroendocrinology 2020 Jul;117:104699
Psychoneuroendocrinology 2020 Jul;117:104699
Up-regulation of sphingosine-1-phosphate receptors and sphingosine kinase 1 in the peri-ischemic area after transient middle cerebral artery occlusion in mice.
Matsumoto N, Yamashita T, Shang J, Feng T, Osakada Y, Sasaki R, Tadokoro K, Nomura E, Tsunoda K, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K
Brain research 2020 Jul 15;1739:146831
Brain research 2020 Jul 15;1739:146831
β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P(2) modulation.
Bruno G, Cencetti F, Pini A, Tondo A, Cuzzubbo D, Fontani F, Strinna V, Buccoliero AM, Casazza G, Donati C, Filippi L, Bruni P, Favre C, Calvani M
Oncogene 2020 Jan;39(2):368-384
Oncogene 2020 Jan;39(2):368-384
Bile acids increase steroidogenesis in cholemic mice and induce cortisol secretion in adrenocortical H295R cells via S1PR2, ERK and SF-1.
Liu L, Panzitt K, Racedo S, Wagner M, Platzer W, Zaufel A, Theiler-Schwetz V, Obermayer-Pietsch B, Müller H, Höfler G, Heinemann A, Zollner G, Fickert P
Liver international : official journal of the International Association for the Study of the Liver 2019 Nov;39(11):2112-2123
Liver international : official journal of the International Association for the Study of the Liver 2019 Nov;39(11):2112-2123
S1P promotes inflammation-induced tube formation by HLECs via the S1PR1/NF-κB pathway.
Zheng Z, Zeng YZ, Ren K, Zhu X, Tan Y, Li Y, Li Q, Yi GH
International immunopharmacology 2019 Jan;66:224-235
International immunopharmacology 2019 Jan;66:224-235
Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2.
Matsushima-Nishiwaki R, Yamada N, Fukuchi K, Kozawa O
PloS one 2018;13(12):e0209050
PloS one 2018;13(12):e0209050
Androgen deficiency impairs erectile function in rats through promotion of corporal fibrosis.
Cui K, Li R, Chen R, Li M, Wang T, Yang J, Chen Z, Wang S, Liu J, Rao K
Andrologia 2018 Feb;50(1)
Andrologia 2018 Feb;50(1)
14-3-3ζ promotes esophageal squamous cell carcinoma invasion by repressing S1PR2 protein expression through NF-κB signaling.
Tong S, Chen SC, Xu KY, Fang B, Wang SH, Wang JJ
Archives of biochemistry and biophysics 2018 Apr 2;643:7-13
Archives of biochemistry and biophysics 2018 Apr 2;643:7-13
S1PR2 antagonist protects endothelial cells against high glucose-induced mitochondrial apoptosis through the Akt/GSK-3β signaling pathway.
Liu H, Peng H, Chen S, Liu Y, Xiang H, Chen R, Chen W, Zhao S, Chen P, Lu H
Biochemical and biophysical research communications 2017 Aug 26;490(3):1119-1124
Biochemical and biophysical research communications 2017 Aug 26;490(3):1119-1124
S1PR2 variants associated with auditory function in humans and endocochlear potential decline in mouse.
Ingham NJ, Carlisle F, Pearson S, Lewis MA, Buniello A, Chen J, Isaacson RL, Pass J, White JK, Dawson SJ, Steel KP
Scientific reports 2016 Jul 7;6:28964
Scientific reports 2016 Jul 7;6:28964
Sphingosine-1-phosphate mediates AKT/ERK maintenance of dental pulp homoeostasis.
Pan HY, Yang H, Shao MY, Xu J, Zhang P, Cheng R, Hu T
International endodontic journal 2015 May;48(5):460-8
International endodontic journal 2015 May;48(5):460-8
Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke.
Kim GS, Yang L, Zhang G, Zhao H, Selim M, McCullough LD, Kluk MJ, Sanchez T
Nature communications 2015 Aug 5;6:7893
Nature communications 2015 Aug 5;6:7893
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The S1PR2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human S1PR2. This antibody recognizes human, mouse, rat antigen. The S1PR2 antibody has been validated for the following applications: ELISA, WB analysis.