21180-1-AP

antibody from Proteintech Group

Targeting: S1PR2 AGR16, DFNB68, EDG5, Gpcr13, H218

Provider product page for 21180-1-AP

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Immunocytochemistry

Antibody data

Antibody Data
Antigen structure
References [46]
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Validations
Western blot [1]

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Product number: 21180-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#21180-1-AP, RRID:AB_10694573
Product name: S1PR2 antibody
Antibody type: Polyclonal
Description: KD/KO validated S1PR2 antibody (Cat. #21180-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

S1PR2 protein structure - 21180-1-AP shown in red.

Submitted references Plantaginis semen ameliorates diabetic kidney disease via targeting the sphingosine kinase 1/sphingosine-1-phosphate pathway.

Lan JP, Xue YF, Pu JY, Ding Y, Gan ZY, Yang YB, Wang ZT, Jie XL, Yang L
Journal of ethnopharmacology 2024 Sep 15;331:118221

Pharmacodynamics and mechanism of Erigeron breviscapus granules in the treatment of ischemic stroke in mice by regulating sphingolipid metabolism based on metabolomics.

Liu C, Liu K, Tao X, Li W, Zhao S, Dai Q, Yao H, Mu F, Chen S, Li J, Dong T, Duan J, Wei P, Gao F, Xi M
Journal of pharmaceutical and biomedical analysis 2024 May 15;242:116058

SPHK1/S1P/S1PR pathway promotes the progression of peritoneal fibrosis by mesothelial-mesenchymal transition.

Zhao T, Ding T, Sun Z, Shao X, Li S, Lu H, Yuan JH, Guo Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23417

Altered sphingolipid pathway in SARS-CoV-2 infected human lung tissue.

Khan RJ, Single SL, Simmons CS, Athar M, Liu Y, Bodduluri S, Benson PV, Goliwas KF, Deshane JS
Frontiers in immunology 2023;14:1216278

S1PR2/Wnt3a/RhoA/ROCK1/β-catenin signaling pathway promotes diabetic nephropathy by inducting endothelial mesenchymal transition and impairing endothelial barrier function.

Zhang J, Chen S, Xiang H, Xiao J, Zhao S, Shu Z, Chai Y, Ouyang J, Liu H, Wang X, Quan Q, Fan J, Gao P, Chen AF, Lu H
Life sciences 2023 Sep 1;328:121853

Estrogen increases the expression of BKCa and impairs the contraction of colon smooth muscle via upregulation of sphingosine kinase 1.

Wang Y, Jiang Y, Jiang L, Xiong W, Wang Y, Gao X, Chen Q, Lin L, Yu T, Tang Y
Journal of cellular physiology 2023 Oct;238(10):2390-2406

Liver sinusoidal endothelial S1pr2 regulates experimental liver fibrosis through YAP/TGF-β signaling pathway.

Liao Y, Zhou C, Duan Y, Liu X, Yue J, Li X, Wu J, Wan C, Zhang L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 May;37(5):e22905

Skeletal muscle insulin resistance and adipose tissue hypertrophy persist beyond the reshaping of gut microbiota in young rats fed a fructose-rich diet.

Mazzoli A, Porzio AD, Gatto C, Crescenzo R, Nazzaro M, Spagnuolo MS, Baccigalupi L, Ricca E, Amoresano A, Fontanarosa C, Bernacchioni C, Donati C, Iossa S, Cigliano L
The Journal of nutritional biochemistry 2023 Mar;113:109247

Sphingosine 1-phosphate receptor 2 promotes the onset and progression of non-alcoholic fatty liver disease-related hepatocellular carcinoma through the PI3K/AKT/mTOR pathway.

Wang G, Zhang X, Zhou Z, Song C, Jin W, Zhang H, Wu W, Yi Y, Cui H, Zhang P, Liu X, Xu W, Shen X, Shen W, Wang X
Discover oncology 2023 Jan 11;14(1):4

Pancreatic Acinar Cells-Derived Sphingosine-1-Phosphate Contributes to Fibrosis of Chronic Pancreatitis via Inducing Autophagy and Activation of Pancreatic Stellate Cells.

Wang D, Han S, Lv G, Hu Y, Zhuo W, Zeng Z, Tang J, Huang Y, Wang F, Wang J, Zhao Y, Zhao G
Gastroenterology 2023 Dec;165(6):1488-1504.e20

Enhanced Activation of the S1PR2-IL-1β-Src-BDNF-TrkB Pathway Mediates Neuroinflammation in the Hippocampus and Cognitive Impairment in Hyperammonemic Rats.

Sancho-Alonso M, Arenas YM, Izquierdo-Altarejos P, Martinez-Garcia M, Llansola M, Felipo V
International journal of molecular sciences 2023 Dec 8;24(24)

Sphingosine 1-phosphate elicits a ROS-mediated proinflammatory response in human endometrial stromal cells via ERK5 activation.

Seidita I, Tusa I, Prisinzano M, Menconi A, Cencetti F, Vannuccini S, Castiglione F, Bruni P, Petraglia F, Bernacchioni C, Rovida E, Donati C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Aug;37(8):e23061

Sphingosine 1-phosphate receptor 1 regulates blood-brain barrier permeability in epileptic mice.

Yang LX, Yao YY, Yang JR, Cheng HL, Zhu XJ, Zhang ZJ
Neural regeneration research 2023 Aug;18(8):1763-1769

S1P/S1PR2 promote pancreatic stellate cell activation and pancreatic fibrosis in chronic pancreatitis by regulating autophagy and the NLRP3 inflammasome.

Cui L, Li C, Zhang G, Zhang L, Yao G, Zhuo Y, Cui N, Zhang S
Chemico-biological interactions 2023 Aug 1;380:110541

Endothelial S1pr2 regulates post-ischemic angiogenesis via AKT/eNOS signaling pathway.

Zhou C, Kuang Y, Li Q, Duan Y, Liu X, Yue J, Chen X, Liu J, Zhang Y, Zhang L
Theranostics 2022;12(11):5172-5188

circSSU72 Promotes Cell Proliferation, Migration and Invasion of Papillary Thyroid Carcinoma Cells by Targeting miR-451a/S1PR2 Axis.

Zhang Z, Xia F, Yao L, Jiang B, Li X
Frontiers in cell and developmental biology 2022;10:817028

Sphingosine 1-phosphate receptor 2 promotes erythrocyte clearance by vascular smooth muscle cells in intraplaque hemorrhage through MFG-E8 production.

Pan D, Wu W, Zuo G, Xie X, Li H, Ren X, Kong C, Zhou W, Zhang Z, Waterfall M, Chen S
Cellular signalling 2022 Oct;98:110419

The function of Sphingosine-1-phosphate receptor 2 (S1PR2) in maintaining intestinal barrier and inducing ulcerative colitis.

Chen T, Gu K, Lin R, Liu Y, Shan Y
Bioengineered 2022 May;13(5):13703-13717

Ameliorative effect of Gastrodia elata Blume extracts on depression in zebrafish and cellular models through modulating reticulon 4 receptors and apoptosis.

Wang R, Ren Q, Gao D, Paudel YN, Li X, Wang L, Zhang P, Wang B, Shang X, Jin M
Journal of ethnopharmacology 2022 May 10;289:115018

YAP signaling in horizontal basal cells promotes the regeneration of olfactory epithelium after injury.

Wu Q, Xu X, Miao X, Bao X, Li X, Xiang L, Wang W, Du S, Lu Y, Wang X, Yang D, Zhang J, Shen X, Li F, Lu S, Fan Y, Xu S, Chen Z, Wang Y, Teng H, Huang Z
Stem cell reports 2022 Mar 8;17(3):664-677

S1PR2/RhoA/ROCK1 pathway promotes inflammatory bowel disease by inducing intestinal vascular endothelial barrier damage and M1 macrophage polarization.

Wang X, Chen S, Xiang H, Wang X, Xiao J, Zhao S, Shu Z, Ouyang J, Liang Z, Deng M, Chen X, Zhang J, Liu H, Quan Q, Gao P, Fan J, Chen AF, Lu H
Biochemical pharmacology 2022 Jul;201:115077

Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways.

Liu K, Sun T, Luan Y, Chen Y, Song J, Ling L, Yuan P, Li R, Cui K, Ruan Y, Lan R, Wang T, Wang S, Liu J, Rao K
Andrology 2022 Feb;10(2):404-418

Protective Effects of Complement Component 8 Gamma Against Blood-Brain Barrier Breakdown.

Kim JH, Han J, Suk K
Frontiers in physiology 2021;12:671250

Therapeutic development of group B Streptococcus meningitis by targeting a host cell signaling network involving EGFR.

Zhu N, Zhang C, Prakash A, Hou Z, Liu W, She W, Morris A, Sik Kim K
EMBO molecular medicine 2021 Mar 5;13(3):e12651

Gamma subunit of complement component 8 is a neuroinflammation inhibitor.

Kim JH, Afridi R, Han J, Jung HG, Kim SC, Hwang EM, Shim HS, Ryu H, Choe Y, Hoe HS, Suk K
Brain : a journal of neurology 2021 Mar 3;144(2):528-552

Effects of S1PR2 antagonist on blood pressure and angiogenesis imbalance in preeclampsia rats.

Zhang T, Guo D, Zheng W, Dai Q
Molecular medicine reports 2021 Jun;23(6)

Sphingosine 1-phosphate signaling in uterine fibroids: implication in activin A pro-fibrotic effect.

Bernacchioni C, Ciarmela P, Vannuzzi V, Greco S, Vannuccini S, Malentacchi F, Pellegrino P, Capezzuoli T, Sorbi F, Cencetti F, Bruni P, Donati C, Petraglia F
Fertility and sterility 2021 Jun;115(6):1576-1585

Nogo-A regulates myogenesis via interacting with Filamin-C.

Park S, Park JH, Kang UB, Choi SK, Elfadl A, Ullah HMA, Chung MJ, Son JY, Yun HH, Park JM, Yim JH, Jung SJ, Kim SH, Choi YC, Kim DS, Shin JH, Park JS, Hur K, Lee SH, Lee EJ, Hwang D, Jeong KS
Cell death discovery 2021 Jan 6;7(1):1

Knockdown of long non‑coding RNA ANRIL inhibits the proliferation and promotes the apoptosis of Burkitt lymphoma cells through the TGF‑β1 signaling pathway.

Mao S, Jin J, Li Z, Yang W
Molecular medicine reports 2021 Feb;23(2)

Raw and wine processed Schisandra chinensis attenuate anxiety like behavior via modulating gut microbiota and lipid metabolism pathway.

Song Y, Shan B, Zeng S, Zhang J, Jin C, Liao Z, Wang T, Zeng Q, He H, Wei F, Ai Z, Su D
Journal of ethnopharmacology 2021 Feb 10;266:113426

Inhibition of sphingosine 1-phosphate (S1P) receptor 1/2/3 ameliorates biological dysfunction in rheumatoid arthritis fibroblast-like synoviocyte MH7A cells through Gαi/Gαs rebalancing.

Wang M, Wu H, Wang R, Dai X, Deng R, Wang Y, Bu Y, Sun M, Zhang H
Clinical and experimental pharmacology & physiology 2021 Aug;48(8):1080-1089

Sphingosine 1-phosphate promotes the proliferation of olfactory ensheathing cells through YAP signaling and participates in the formation of olfactory nerve layer.

Bao X, Xu X, Wu Q, Zhang J, Feng W, Yang D, Li F, Lu S, Liu H, Shen X, Zhang F, Xie C, Wu S, Lv Z, Wang W, Li H, Fang Y, Wang Y, Teng H, Huang Z
Glia 2020 Sep;68(9):1757-1774

Targeting E. coli invasion of the blood-brain barrier for investigating the pathogenesis and therapeutic development of E. coli meningitis.

Zhu N, Liu W, Prakash A, Zhang C, Kim KS
Cellular microbiology 2020 Oct;22(10):e13231

JTE-013 supplementation improves erectile dysfunction in rats with streptozotocin-induced type Ⅰ diabetes through the inhibition of the rho-kinase pathway, fibrosis, and apoptosis.

Liu K, Cui K, Feng H, Li R, Lin H, Chen Y, Zhang Y, Chen Z, Yuan H, Li M, Wang T, Lan R, Liu J, Rao K, Wen B
Andrology 2020 Mar;8(2):497-508

Gut microbiome-derived lactate promotes to anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway.

Shan B, Ai Z, Zeng S, Song Y, Song J, Zeng Q, Liao Z, Wang T, Huang C, Su D
Psychoneuroendocrinology 2020 Jul;117:104699

Up-regulation of sphingosine-1-phosphate receptors and sphingosine kinase 1 in the peri-ischemic area after transient middle cerebral artery occlusion in mice.

Matsumoto N, Yamashita T, Shang J, Feng T, Osakada Y, Sasaki R, Tadokoro K, Nomura E, Tsunoda K, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K
Brain research 2020 Jul 15;1739:146831

β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P(2) modulation.

Bruno G, Cencetti F, Pini A, Tondo A, Cuzzubbo D, Fontani F, Strinna V, Buccoliero AM, Casazza G, Donati C, Filippi L, Bruni P, Favre C, Calvani M
Oncogene 2020 Jan;39(2):368-384

Bile acids increase steroidogenesis in cholemic mice and induce cortisol secretion in adrenocortical H295R cells via S1PR2, ERK and SF-1.

Liu L, Panzitt K, Racedo S, Wagner M, Platzer W, Zaufel A, Theiler-Schwetz V, Obermayer-Pietsch B, Müller H, Höfler G, Heinemann A, Zollner G, Fickert P
Liver international : official journal of the International Association for the Study of the Liver 2019 Nov;39(11):2112-2123

S1P promotes inflammation-induced tube formation by HLECs via the S1PR1/NF-κB pathway.

Zheng Z, Zeng YZ, Ren K, Zhu X, Tan Y, Li Y, Li Q, Yi GH
International immunopharmacology 2019 Jan;66:224-235

Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2.

Matsushima-Nishiwaki R, Yamada N, Fukuchi K, Kozawa O
PloS one 2018;13(12):e0209050

Androgen deficiency impairs erectile function in rats through promotion of corporal fibrosis.

Cui K, Li R, Chen R, Li M, Wang T, Yang J, Chen Z, Wang S, Liu J, Rao K
Andrologia 2018 Feb;50(1)

14-3-3ζ promotes esophageal squamous cell carcinoma invasion by repressing S1PR2 protein expression through NF-κB signaling.

Tong S, Chen SC, Xu KY, Fang B, Wang SH, Wang JJ
Archives of biochemistry and biophysics 2018 Apr 2;643:7-13

S1PR2 antagonist protects endothelial cells against high glucose-induced mitochondrial apoptosis through the Akt/GSK-3β signaling pathway.

Liu H, Peng H, Chen S, Liu Y, Xiang H, Chen R, Chen W, Zhao S, Chen P, Lu H
Biochemical and biophysical research communications 2017 Aug 26;490(3):1119-1124

S1PR2 variants associated with auditory function in humans and endocochlear potential decline in mouse.

Ingham NJ, Carlisle F, Pearson S, Lewis MA, Buniello A, Chen J, Isaacson RL, Pass J, White JK, Dawson SJ, Steel KP
Scientific reports 2016 Jul 7;6:28964

Sphingosine-1-phosphate mediates AKT/ERK maintenance of dental pulp homoeostasis.

Pan HY, Yang H, Shao MY, Xu J, Zhang P, Cheng R, Hu T
International endodontic journal 2015 May;48(5):460-8

Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke.

Kim GS, Yang L, Zhang G, Zhao H, Selim M, McCullough LD, Kluk MJ, Sanchez T
Nature communications 2015 Aug 5;6:7893

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Submitted by: Proteintech Group (provider)
Main image
Experimental details: The S1PR2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human S1PR2. This antibody recognizes human, mouse, rat antigen. The S1PR2 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 21180-1-AP.pdf

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