Antibody data
- Antibody Data
- Antigen structure
- References [25]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 21180-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21180-1-AP, RRID:AB_10694573
- Product name
- S1PR2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated S1PR2 antibody (Cat. #21180-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways.
Protective Effects of Complement Component 8 Gamma Against Blood-Brain Barrier Breakdown.
Therapeutic development of group B Streptococcus meningitis by targeting a host cell signaling network involving EGFR.
Gamma subunit of complement component 8 is a neuroinflammation inhibitor.
Effects of S1PR2 antagonist on blood pressure and angiogenesis imbalance in preeclampsia rats.
Sphingosine 1-phosphate signaling in uterine fibroids: implication in activin A pro-fibrotic effect.
Nogo-A regulates myogenesis via interacting with Filamin-C.
Knockdown of long non‑coding RNA ANRIL inhibits the proliferation and promotes the apoptosis of Burkitt lymphoma cells through the TGF‑β1 signaling pathway.
Raw and wine processed Schisandra chinensis attenuate anxiety like behavior via modulating gut microbiota and lipid metabolism pathway.
Inhibition of sphingosine 1-phosphate (S1P) receptor 1/2/3 ameliorates biological dysfunction in rheumatoid arthritis fibroblast-like synoviocyte MH7A cells through Gαi/Gαs rebalancing.
Sphingosine 1-phosphate promotes the proliferation of olfactory ensheathing cells through YAP signaling and participates in the formation of olfactory nerve layer.
Targeting E. coli invasion of the blood-brain barrier for investigating the pathogenesis and therapeutic development of E. coli meningitis.
JTE-013 supplementation improves erectile dysfunction in rats with streptozotocin-induced type Ⅰ diabetes through the inhibition of the rho-kinase pathway, fibrosis, and apoptosis.
Gut microbiome-derived lactate promotes to anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway.
Up-regulation of sphingosine-1-phosphate receptors and sphingosine kinase 1 in the peri-ischemic area after transient middle cerebral artery occlusion in mice.
β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P2 modulation.
Bile acids increase steroidogenesis in cholemic mice and induce cortisol secretion in adrenocortical H295R cells via S1PR2, ERK and SF-1.
S1P promotes inflammation-induced tube formation by HLECs via the S1PR1/NF-κB pathway.
Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2.
Androgen deficiency impairs erectile function in rats through promotion of corporal fibrosis.
14-3-3ζ promotes esophageal squamous cell carcinoma invasion by repressing S1PR2 protein expression through NF-κB signaling.
S1PR2 antagonist protects endothelial cells against high glucose-induced mitochondrial apoptosis through the Akt/GSK-3β signaling pathway.
S1PR2 variants associated with auditory function in humans and endocochlear potential decline in mouse.
Sphingosine-1-phosphate mediates AKT/ERK maintenance of dental pulp homoeostasis.
Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke.
Liu K, Sun T, Luan Y, Chen Y, Song J, Ling L, Yuan P, Li R, Cui K, Ruan Y, Lan R, Wang T, Wang S, Liu J, Rao K
Andrology 2022 Feb;10(2):404-418
Andrology 2022 Feb;10(2):404-418
Protective Effects of Complement Component 8 Gamma Against Blood-Brain Barrier Breakdown.
Kim JH, Han J, Suk K
Frontiers in physiology 2021;12:671250
Frontiers in physiology 2021;12:671250
Therapeutic development of group B Streptococcus meningitis by targeting a host cell signaling network involving EGFR.
Zhu N, Zhang C, Prakash A, Hou Z, Liu W, She W, Morris A, Sik Kim K
EMBO molecular medicine 2021 Mar 5;13(3):e12651
EMBO molecular medicine 2021 Mar 5;13(3):e12651
Gamma subunit of complement component 8 is a neuroinflammation inhibitor.
Kim JH, Afridi R, Han J, Jung HG, Kim SC, Hwang EM, Shim HS, Ryu H, Choe Y, Hoe HS, Suk K
Brain : a journal of neurology 2021 Mar 3;144(2):528-552
Brain : a journal of neurology 2021 Mar 3;144(2):528-552
Effects of S1PR2 antagonist on blood pressure and angiogenesis imbalance in preeclampsia rats.
Zhang T, Guo D, Zheng W, Dai Q
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
Sphingosine 1-phosphate signaling in uterine fibroids: implication in activin A pro-fibrotic effect.
Bernacchioni C, Ciarmela P, Vannuzzi V, Greco S, Vannuccini S, Malentacchi F, Pellegrino P, Capezzuoli T, Sorbi F, Cencetti F, Bruni P, Donati C, Petraglia F
Fertility and sterility 2021 Jun;115(6):1576-1585
Fertility and sterility 2021 Jun;115(6):1576-1585
Nogo-A regulates myogenesis via interacting with Filamin-C.
Park S, Park JH, Kang UB, Choi SK, Elfadl A, Ullah HMA, Chung MJ, Son JY, Yun HH, Park JM, Yim JH, Jung SJ, Kim SH, Choi YC, Kim DS, Shin JH, Park JS, Hur K, Lee SH, Lee EJ, Hwang D, Jeong KS
Cell death discovery 2021 Jan 6;7(1):1
Cell death discovery 2021 Jan 6;7(1):1
Knockdown of long non‑coding RNA ANRIL inhibits the proliferation and promotes the apoptosis of Burkitt lymphoma cells through the TGF‑β1 signaling pathway.
Mao S, Jin J, Li Z, Yang W
Molecular medicine reports 2021 Feb;23(2)
Molecular medicine reports 2021 Feb;23(2)
Raw and wine processed Schisandra chinensis attenuate anxiety like behavior via modulating gut microbiota and lipid metabolism pathway.
Song Y, Shan B, Zeng S, Zhang J, Jin C, Liao Z, Wang T, Zeng Q, He H, Wei F, Ai Z, Su D
Journal of ethnopharmacology 2021 Feb 10;266:113426
Journal of ethnopharmacology 2021 Feb 10;266:113426
Inhibition of sphingosine 1-phosphate (S1P) receptor 1/2/3 ameliorates biological dysfunction in rheumatoid arthritis fibroblast-like synoviocyte MH7A cells through Gαi/Gαs rebalancing.
Wang M, Wu H, Wang R, Dai X, Deng R, Wang Y, Bu Y, Sun M, Zhang H
Clinical and experimental pharmacology & physiology 2021 Aug;48(8):1080-1089
Clinical and experimental pharmacology & physiology 2021 Aug;48(8):1080-1089
Sphingosine 1-phosphate promotes the proliferation of olfactory ensheathing cells through YAP signaling and participates in the formation of olfactory nerve layer.
Bao X, Xu X, Wu Q, Zhang J, Feng W, Yang D, Li F, Lu S, Liu H, Shen X, Zhang F, Xie C, Wu S, Lv Z, Wang W, Li H, Fang Y, Wang Y, Teng H, Huang Z
Glia 2020 Sep;68(9):1757-1774
Glia 2020 Sep;68(9):1757-1774
Targeting E. coli invasion of the blood-brain barrier for investigating the pathogenesis and therapeutic development of E. coli meningitis.
Zhu N, Liu W, Prakash A, Zhang C, Kim KS
Cellular microbiology 2020 Oct;22(10):e13231
Cellular microbiology 2020 Oct;22(10):e13231
JTE-013 supplementation improves erectile dysfunction in rats with streptozotocin-induced type Ⅰ diabetes through the inhibition of the rho-kinase pathway, fibrosis, and apoptosis.
Liu K, Cui K, Feng H, Li R, Lin H, Chen Y, Zhang Y, Chen Z, Yuan H, Li M, Wang T, Lan R, Liu J, Rao K, Wen B
Andrology 2020 Mar;8(2):497-508
Andrology 2020 Mar;8(2):497-508
Gut microbiome-derived lactate promotes to anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway.
Shan B, Ai Z, Zeng S, Song Y, Song J, Zeng Q, Liao Z, Wang T, Huang C, Su D
Psychoneuroendocrinology 2020 Jul;117:104699
Psychoneuroendocrinology 2020 Jul;117:104699
Up-regulation of sphingosine-1-phosphate receptors and sphingosine kinase 1 in the peri-ischemic area after transient middle cerebral artery occlusion in mice.
Matsumoto N, Yamashita T, Shang J, Feng T, Osakada Y, Sasaki R, Tadokoro K, Nomura E, Tsunoda K, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K
Brain research 2020 Jul 15;1739:146831
Brain research 2020 Jul 15;1739:146831
β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P2 modulation.
Bruno G, Cencetti F, Pini A, Tondo A, Cuzzubbo D, Fontani F, Strinna V, Buccoliero AM, Casazza G, Donati C, Filippi L, Bruni P, Favre C, Calvani M
Oncogene 2020 Jan;39(2):368-384
Oncogene 2020 Jan;39(2):368-384
Bile acids increase steroidogenesis in cholemic mice and induce cortisol secretion in adrenocortical H295R cells via S1PR2, ERK and SF-1.
Liu L, Panzitt K, Racedo S, Wagner M, Platzer W, Zaufel A, Theiler-Schwetz V, Obermayer-Pietsch B, Müller H, Höfler G, Heinemann A, Zollner G, Fickert P
Liver international : official journal of the International Association for the Study of the Liver 2019 Nov;39(11):2112-2123
Liver international : official journal of the International Association for the Study of the Liver 2019 Nov;39(11):2112-2123
S1P promotes inflammation-induced tube formation by HLECs via the S1PR1/NF-κB pathway.
Zheng Z, Zeng YZ, Ren K, Zhu X, Tan Y, Li Y, Li Q, Yi GH
International immunopharmacology 2019 Jan;66:224-235
International immunopharmacology 2019 Jan;66:224-235
Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2.
Matsushima-Nishiwaki R, Yamada N, Fukuchi K, Kozawa O
PloS one 2018;13(12):e0209050
PloS one 2018;13(12):e0209050
Androgen deficiency impairs erectile function in rats through promotion of corporal fibrosis.
Cui K, Li R, Chen R, Li M, Wang T, Yang J, Chen Z, Wang S, Liu J, Rao K
Andrologia 2018 Feb;50(1)
Andrologia 2018 Feb;50(1)
14-3-3ζ promotes esophageal squamous cell carcinoma invasion by repressing S1PR2 protein expression through NF-κB signaling.
Tong S, Chen SC, Xu KY, Fang B, Wang SH, Wang JJ
Archives of biochemistry and biophysics 2018 Apr 2;643:7-13
Archives of biochemistry and biophysics 2018 Apr 2;643:7-13
S1PR2 antagonist protects endothelial cells against high glucose-induced mitochondrial apoptosis through the Akt/GSK-3β signaling pathway.
Liu H, Peng H, Chen S, Liu Y, Xiang H, Chen R, Chen W, Zhao S, Chen P, Lu H
Biochemical and biophysical research communications 2017 Aug 26;490(3):1119-1124
Biochemical and biophysical research communications 2017 Aug 26;490(3):1119-1124
S1PR2 variants associated with auditory function in humans and endocochlear potential decline in mouse.
Ingham NJ, Carlisle F, Pearson S, Lewis MA, Buniello A, Chen J, Isaacson RL, Pass J, White JK, Dawson SJ, Steel KP
Scientific reports 2016 Jul 7;6:28964
Scientific reports 2016 Jul 7;6:28964
Sphingosine-1-phosphate mediates AKT/ERK maintenance of dental pulp homoeostasis.
Pan HY, Yang H, Shao MY, Xu J, Zhang P, Cheng R, Hu T
International endodontic journal 2015 May;48(5):460-8
International endodontic journal 2015 May;48(5):460-8
Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke.
Kim GS, Yang L, Zhang G, Zhao H, Selim M, McCullough LD, Kluk MJ, Sanchez T
Nature communications 2015 Aug 5;6:7893
Nature communications 2015 Aug 5;6:7893
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The S1PR2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human S1PR2. This antibody recognizes human, mouse, rat antigen. The S1PR2 antibody has been validated for the following applications: ELISA, WB analysis.