HPA001196

antibody from Atlas Antibodies

Targeting: AMOTL1 JEAP

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

HPA001196

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA001196, RRID:AB_1078147

Product name

Anti-AMOTL1

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human AMOTL1, Gene description: angiomotin like 1, Alternative Gene Names: JEAP, Validated applications: ICC, IHC, Uniprot ID: Q8IY63, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.2 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

Proteolytic activation of angiomotin by DDI2 promotes angiogenesis

Wang Y, Zhu Y, Wang Y, Chang Y, Geng F, Ma M, Gu Y, Yu A, Zhu R, Yu P, Sha Z, Qi S, Li J, Zhao W, Pan W, Zhang R, Yu F
The EMBO Journal 2023;42(15)

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Tankyrase inhibition interferes with junction remodeling, induces leakiness, and disturbs YAP1/TAZ signaling in the endothelium

Ma N, Wibowo Y, Wirtz P, Baltus D, Wieland T, Jansen S
Naunyn-Schmiedeberg's Archives of Pharmacology 2023;397(3):1763-1789

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AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis

Zhou Y, Zhang J, Li H, Huang T, Wong C, Wu F, Wu M, Weng N, Liu L, Cheng A, Yu J, Wong N, Lo K, Tang P, Kang W, To K
Oncogene 2020;39(22):4375-4389

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AMOT130 drives BMP-SMAD signaling at the apical membrane in polarized cells

Brunner P, Hastar N, Kaehler C, Burdzinski W, Jatzlau J, Knaus P, Luo K
Molecular Biology of the Cell 2020;31(2):118-130

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NEDD4L‐mediated Merlin ubiquitination facilitates Hippo pathway activation

Wei Y, Yee P, Liu Z, Zhang L, Guo H, Zheng H, Anderson B, Gulley M, Li W
EMBO reports 2020;21(12)

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Elucidation of WW domain ligand binding specificities in the Hippo pathway reveals STXBP 4 as YAP inhibitor

Vargas R, Duong V, Han H, Ta A, Chen Y, Zhao S, Yang B, Seo G, Chuc K, Oh S, El Ali A, Razorenova O, Chen J, Luo R, Li X, Wang W
The EMBO Journal 2019;39(1)

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Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth

Ragni C, Diguet N, Le Garrec J, Novotova M, Resende T, Pop S, Charon N, Guillemot L, Kitasato L, Badouel C, Dufour A, Olivo-Marin J, Trouvé A, McNeill H, Meilhac S
Nature Communications 2017;8(1)

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Angiomotin-like 2 interacts with and negatively regulates AKT

Han H, Yang B, Wang W
Oncogene 2017;36(32):4662-4669

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AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin

Couderc C, Boin A, Fuhrmann L, Vincent-Salomon A, Mandati V, Kieffer Y, Mechta-Grigoriou F, Del Maestro L, Chavrier P, Vallerand D, Brito I, Dubois T, De Koning L, Bouvard D, Louvard D, Gautreau A, Lallemand D
Neoplasia 2016;18(1):10-24