13885-1-AP

antibody from Proteintech Group

Targeting: CX3CR1 CCRL1, CMKBRL1, CMKDR1, GPR13, V28

Provider product page for 13885-1-AP

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Immunoprecipitation

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Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [32]
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Western blot [1]

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Product number: 13885-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#13885-1-AP, RRID:AB_2087418
Product name: CX3CR1 antibody
Antibody type: Polyclonal
Description: CX3CR1 antibody (Cat. #13885-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CX3CR1 protein structure - 13885-1-AP shown in red.

Submitted references Neutrophil extracellular trap-mediated impairment of meningeal lymphatic drainage exacerbates secondary hydrocephalus after intraventricular hemorrhage.

Zhang Q, Chen Y, Li Y, Feng Z, Liang L, Hao X, Kang W, Zhang Z, Zhang X, Hu R, Feng H, Chen Z
Theranostics 2024;14(5):1909-1938

Knee Osteotomy Decreases Joint Inflammation Based on Synovial Histology and Synovial Fluid Analysis.

Watanabe S, Matsushita T, Nishida K, Nagai K, Hoshino Y, Matsumoto T, Kuroda R
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 2024 Mar;40(3):830-843

Possible involvement of microglial P2RY12 and peripheral IL-10 in postpartum depression.

Kim HJ, You MJ, Sung S, Rim C, Kwon MS
Frontiers in cellular neuroscience 2023;17:1162966

Experimental traumatic occlusion drives immune changes in trigeminal ganglion.

Clemente-Napimoga JT, Mendes V, Trindade-da-Silva CA, Carvalho G, Paranhos ACGA, Andrade E Silva F, Buarque E Silva WA, Napimoga MH, Abdalla HB
International immunopharmacology 2023 Sep;122:110674

hESC-Derived Epicardial Cells Promote Repair of Infarcted Hearts in Mouse and Swine.

Luo XL, Jiang Y, Li Q, Yu XJ, Ma T, Cao H, Ke MX, Zhang P, Tan JL, Gong YS, Wang L, Gao L, Yang HT
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(27):e2300470

Baicalein ameliorates Alzheimer's disease via orchestration of CX3CR1/NF-κB pathway in a triple transgenic mouse model.

Xie XM, Hao JJ, Shi JZ, Zhou YF, Liu PF, Wang F, Zheng XM, Yu XY, Wang CC, Yan Y, Du GH, Song JK, He YY, Pang XB
International immunopharmacology 2023 May;118:109994

CX3CR1(hi) macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue.

Zhou Z, Zhang H, Tao Y, Jie H, Zhao J, Zang J, Li H, Wang Y, Wang T, Zhao H, Li Y, Guo C, Zhu F, Mao H, Zhang L, Liu F, Wang Q
Cell reports 2023 May 30;42(5):112424

Microglial targeted therapy relieves cognitive impairment caused by Cntnap4 deficiency.

Zhang W, Chen H, Ding L, Huang J, Zhang M, Liu Y, Ma R, Zheng S, Gong J, Piña-Crespo JC, Zhang Y
Exploration (Beijing, China) 2023 Jun;3(3):20220160

CX3CL1/CX3CR1 axis alleviates inflammation and apoptosis in human nucleus pulpous cells via M2 macrophage polarization.

Gao XW, Hu HL, Xie MH, Tang CX, Ou J, Lu ZH
Experimental and therapeutic medicine 2023 Jul;26(1):359

CX3CL1 deficiency ameliorates inflammation, apoptosis and accelerates osteogenic differentiation, mineralization in LPS-treated MC3T3-E1 cells via its receptor CX3CR1.

Lu Z, Zhang A, Dai Y
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2023 Feb;246:152036

Identification and validation of key biomarkers associated with macrophages in nonalcoholic fatty liver disease based on hdWGCNA and machine learning.

Li R, Zhao M, Miao C, Shi X, Lu J
Aging 2023 Dec 21;15(24):15451-15472

Analysis of Aβ-induced neurotoxicity and microglial responses in simple two- and three-dimensional human iPSC-derived cortical culture systems.

Takata M, Nishimura K, Harada K, Iwasaki R, Ando M, Yamada S, Ginhoux F, Takata K
Tissue & cell 2023 Apr;81:102023

Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis.

Tong L, Zhang S, Liu Q, Huang C, Hao H, Tan MS, Yu X, Lou CKL, Huang R, Zhang Z, Liu T, Gong P, Ng CH, Muthiah M, Pastorin G, Wacker MG, Chen X, Storm G, Lee CN, Zhang L, Yi H, Wang JW
Science advances 2023 Apr 14;9(15):eade5041

Diet-Induced Obesity Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma via CX3CL1/CX3CR1 Axis.

Sun Y, Zhang XX, Huang S, Pan H, Gai YZ, Zhou YQ, Zhu L, Nie HZ, Li DX
Journal of immunology research 2022;2022:5665964

Activation of the Chemokine Receptor CCR1 and Preferential Recruitment of Gαi Suppress RSV Replication: Implications for Developing Novel Respiratory Syncytial Virus Treatment Strategies.

Li J, Xue L, Wang J, Meng A, Qiao J, Li M, Wang X, Meng L, Ning J, Gao X, Li W, Ma C, Wei L
Journal of virology 2022 Nov 23;96(22):e0130922

Calming egress of inflammatory monocytes and related septic shock by therapeutic CCR2 silencing using macrophage-derived extracellular vesicles.

Ding L, Zhou W, Zhang J, Tang Q, Xiao W, Chen M, Shen Z, Chen W
Nanoscale 2022 Mar 31;14(13):4935-4945

Biomimetic GBM-targeted drug delivery system boosting ferroptosis for immunotherapy of orthotopic drug-resistant GBM.

Liu B, Ji Q, Cheng Y, Liu M, Zhang B, Mei Q, Liu D, Zhou S
Journal of nanobiotechnology 2022 Mar 27;20(1):161

Multiple Mild Stimulations Reduce Membrane Distribution of CX3CR1 Promoted by Annexin a1 in Microglia to Attenuate Excessive Dendritic Spine Pruning and Cognitive Deficits Caused by a Transient Ischemic Attack in Mice.

Zheng L, Wang Y, Shao B, Zhou H, Li X, Zhang C, Sun N, Shi J
Neuroscience bulletin 2022 Jul;38(7):753-768

Differential expression of long non-coding RNAs in the hippocampus of mice exposed to PM(2.5) in Dalian, China.

Li J, Zhang L, Wang J, Jia R, Zhang X, Li X, Fu Y, Song L
Environmental science and pollution research international 2022 Feb;29(8):12136-12146

CX3CR1 regulates angiogenesis and activation of pro-angiogenic factors and triggers macrophage accumulation in experimental hepatopulmonary syndrome model.

Liu H, Gu H, Gu L, Liao J, Yang X, Wu C, Ran X, Feng X, Zuo S, Li H
Gastroenterologia y hepatologia 2021 Feb;44(2):115-124

Tetrahydroxy stilbene glycoside regulates TGF-β/fractalkine/CX3CR1 based on network pharmacology in APP/PS1 mouse model.

Gao Y, Hu K, Yang J, Wang S, Li J, Wu Q, Wang Z, Chen N, Li L, Zhang L
Neuropeptides 2021 Dec;90:102197

C-X3-C motif chemokine ligand 1/receptor 1 regulates the M1 polarization and chemotaxis of macrophages after hypoxia/reoxygenation injury.

Guo S, Dong L, Li J, Chen Y, Yao Y, Zeng R, Shushakova N, Haller H, Xu G, Rong S
Chronic diseases and translational medicine 2021 Dec;7(4):254-265

Reactive microglia enhance the transmission of exosomal α-synuclein via toll-like receptor 2.

Xia Y, Zhang G, Kou L, Yin S, Han C, Hu J, Wan F, Sun Y, Wu J, Li Y, Huang J, Xiong N, Zhang Z, Wang T
Brain : a journal of neurology 2021 Aug 17;144(7):2024-2037

Chemoattractants driven and microglia based biomimetic nanoparticle treating TMZ-resistant glioblastoma multiforme.

Qiao S, Cheng Y, Liu M, Ji Q, Zhang B, Mei Q, Liu D, Zhou S
Journal of controlled release : official journal of the Controlled Release Society 2021 Aug 10;336:54-70

Platelets are recruited to hepatocellular carcinoma tissues in a CX3CL1-CX3CR1 dependent manner and induce tumour cell apoptosis.

Miao S, Lu M, Liu Y, Shu D, Zhu Y, Song W, Ma Y, Ma R, Zhang B, Fang C, Ming ZY
Molecular oncology 2020 Oct;14(10):2546-2559

Modulatory effect of botulinum toxin type A on the microglial P2X7/CatS/FKN activated-pathway in antigen-induced arthritis of the temporomandibular joint of rats.

Manuel Muñoz-Lora VR, Abdalla HB, Del Bel Cury AA, Clemente-Napimoga JT
Toxicon : official journal of the International Society on Toxinology 2020 Nov;187:116-121

TL1A primed dendritic cells activation exacerbated chronic murine colitis.

Han F, Song J, Jia W, Yang M, Wang D, Zhang H, Shih DQ, Targan SR, Zhang X
Life sciences 2020 Dec 1;262:118220

Maternal Nicotine Exposure During Gestation and Lactation Period Affects Behavior and Hippocampal Neurogenesis in Mouse Offspring.

Liu F, Tao X, Pang G, Wu D, Hu Y, Xue S, Liu J, Li B, Zhou L, Liu Q, Zhang YM
Frontiers in pharmacology 2019;10:1569

The P2X7 Receptor, Cathepsin S and Fractalkine in the Trigeminal Subnucleus Caudalis Signal Persistent Hypernociception in Temporomandibular Rat Joints.

Bonfante R, Napimoga MH, Macedo CG, Abdalla HB, Pieroni V, Clemente-Napimoga JT
Neuroscience 2018 Nov 1;391:120-130

Immunohistochemical and Molecular Investigations Show Alteration in the Inflammatory Profile of Multiple System Atrophy Brain.

Kiely AP, Murray CE, Foti SC, Benson BC, Courtney R, Strand C, Lashley T, Holton JL
Journal of neuropathology and experimental neurology 2018 Jul 1;77(7):598-607

Fractalkine/CX3CR1 induces apoptosis resistance and proliferation through the activation of the AKT/NF-κB cascade in pancreatic cancer cells.

Wang H, Cai J, Du S, Guo Z, Xin B, Wang J, Wei W, Shen X
Cell biochemistry and function 2017 Aug;35(6):315-326

Treatment with tanshinone IIA suppresses disruption of the blood-brain barrier and reduces expression of adhesion molecules and chemokines in experimental autoimmune encephalomyelitis.

Yang X, Yan J, Feng J
European journal of pharmacology 2016 Jan 15;771:18-28

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The CX3CR1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CX3CR1. This antibody recognizes human,mouse,rat antigen. The CX3CR1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 13885-1-AP.pdf

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