CABT-L1260

antibody from Creative Diagnostics

Targeting: CX3CR1 CCRL1, CMKBRL1, CMKDR1, GPR13, V28

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Antibody Data

Product number

CABT-L1260

Provider

Creative Diagnostics

Product name

Rabbit Anti-Human CX3CR1 monoclonal antibody, clone 2I25M8

Antibody type

Monoclonal

Description

Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. They are classified based on the positions of key cysteine residues. CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. Recent experiments have shown that CX3CL1 can suppress the production of nitrous oxide, interleukin-6, and TNF-a in activated microglia and neuronal cells, suggesting that it may act as an intrinsic inhibitor against neurotoxicity by activated microglia. Its receptor, CX3CR1, also functions as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by CX3CL1.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

2I25M8

Concentration

0.5 mg/ml

Storage

-20°C, Avoid Freeze/Thaw Cycles