PA5-63051

antibody from Invitrogen Antibodies

Targeting: FOCAD FLJ20375, KIAA1797

Immunohistochemistry (Recommended by provider)

Other assay (Supportive data in Antibodypedia)

Antibody Data

Product number

PA5-63051

Provider

Invitrogen Antibodies

Product name

FOCAD Polyclonal Antibody

Antibody type

Polyclonal

Antigen

Recombinant full-length protein

Description

Immunogen sequence: NWAALLSPLM RLNFGEEIQQ LCLEIMVTQA QSSQNAAALL GLWVTPPLIH SLSLNTKRYL LISAPLWIKH ISDEQILGFV ENLMVAVFKA ASPLGSPELC PSALHGLSQA MKLPSPAHHL WSLLSEA Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 80%.

Reactivity

Human

Host

Rabbit

Isotype

IgG

Vial size

100 µL

Concentration

0.08 mg/mL

Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

References

Submitted references

NRF2 regulates the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via FOCAD-FAK signaling pathway.

Liu P, Wu D, Duan J, Xiao H, Zhou Y, Zhao L, Feng Y
Redox biology 2020 Oct;37:101702

Other assay

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Fig. 1 The expression of NRF2 and FOCAD in human NSCLC tissues. The cancer tissues and paracancer tissues from 6 NSCLC patients (Patient-001 to Patient-006) were harvested for NRF2 and FOCAD via IHC staining (A). In the negative control, non-specific IgG was used to replace the first antibody. The cancer slice from patient-001 was used in the negative control of NRF2 staining (A1), and the paracancer slice from patient-001 was used in the negative control of FOCAD staining (A2). The relative intensity of NRF2 (B) and FOCAD (C) were calculated respectively, and the level in Cancer group was considered as ""1"". Results were expressed as mean +- SD, and the P value less than 0.05 was considered statistically significant. *: P < 0.05 compared between cancer tissue and paracancer. Fig. 1