14167-1-AP

antibody from Proteintech Group

Targeting: IRF9 ISGF3G

Provider product page for 14167-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [49]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 14167-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14167-1-AP, RRID:AB_2296227
Product name: IRF9 antibody
Antibody type: Polyclonal
Description: IRF9 antibody (Cat. #14167-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

IRF9 protein structure - 14167-1-AP shown in red.

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Tubule-Derived IFN-α Promotes GSDMD-Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation.

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Targeting leucine-rich repeat kinase 2 overcomes resistance to oncolytic herpes simplex virus-based therapies in glioblastoma.

Qin Y, Liang Z, Yu M, Lin N, Wang N, Huang X, Chen S, Peng Q, Lin Y, Wang H, Rao Y, Xu Z, Huang S, Cai J, Li Y, Zhang J, Lin C, Tan G, Xia N, Huang C
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Construction and immunohistochemical validation of a necroptosis-related prognostic signature in bladder cancer and its association with tumor immune infiltration.

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bioRxiv : the preprint server for biology 2025 Mar 14;

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African swine fever virus MGF505-4R facilitates cGAS degradation through TOLLIP-mediated selective autophagy and inhibits the formation of ISGF3 to evade innate immunity.

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FAM210B activates STAT1/IRF9/IFIT3 axis by upregulating IFN-α/β expression to impede the progression of lung adenocarcinoma.

Gao X, Huang D, Liu Y, Zhang G, Zheng X, Guan B, Chen A, Wu J, Luo SM, Liu Z, Chen L, Liu X, Jin J, Yin X, Sun Z, Zhang Y, Lu M, Zhang G, Liu W, Liu L
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Bioinformatics analysis and validation of novel biomarkers and competitive endogenous RNA networks involved in pyroptosis in diabetic nephropathy.

Wu S, Yao L, Zhang W, Chen P, Jiang J, Ma Y
Scientific reports 2025 Feb 14;15(1):5530

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Xie W, Gao X, Zhao L, Song S, Li NA, Liu J
Journal of biosciences 2024;49

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Sun Z, Hu Y, Qu J, Zhao Q, Gao H, Peng Z
Frontiers in genetics 2024;15:1389630

Increased Thyroid Hormone Action Alleviates Hippocampal Damage by Downregulating Neuronal Type I Interferon Signaling/Necroptosis in Diabetes-Associated Cognitive Dysfunction.

Tian L, Li X, Zeng X, Han Y, Qian M, Ye Y, Lin L, Li Y, Zhang J, Liu Y, Sun Y
Thyroid : official journal of the American Thyroid Association 2024 Oct;34(10):1292-1307

pK205R targets the proximal element of IFN-I signaling pathway to assist African swine fever virus to escape host innate immunity at the early stage of infection.

Huang Z, Kong C, Zhang W, You J, Gao C, Yi J, Mai Z, Chen X, Zhou P, Gong L, Zhang G, Wang H
PLoS pathogens 2024 Oct;20(10):e1012613

African swine fever virus pB475L evades host antiviral innate immunity via targeting STAT2 to inhibit IFN-I signaling.

Huang Z, Mai Z, Kong C, You J, Lin S, Gao C, Zhang W, Chen X, Xie Q, Wang H, Tang S, Zhou P, Gong L, Zhang G
The Journal of biological chemistry 2024 Jul;300(7):107472

Geniposide attenuates influenza virus-induced pneumonia by regulating inflammatory cytokines production. Evidences to elucidate the followed pathway.

Zhang Y, Wang P, Geng Z, Bao L, Gao S, Sun J, Liu X, Yang X, Zhao R, Li S, Bao Y, Cui X, Guo S
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Fan X, Wei J, Guo Y, Ma J, Qi M, Huang H, Zheng P, Jiang W, Yao Y
International journal of molecular sciences 2024 Dec 21;25(24)

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Research (Washington, D.C.) 2023;6:0033

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Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria.

Rosain J, Neehus AL, Manry J, Yang R, Le Pen J, Daher W, Liu Z, Chan YH, Tahuil N, Türel Ö, Bourgey M, Ogishi M, Doisne JM, Izquierdo HM, Shirasaki T, Le Voyer T, Guérin A, Bastard P, Moncada-Vélez M, Han JE, Khan T, Rapaport F, Hong SH, Cheung A, Haake K, Mindt BC, Pérez L, Philippot Q, Lee D, Zhang P, Rinchai D, Al Ali F, Ahmad Ata MM, Rahman M, Peel JN, Heissel S, Molina H, Kendir-Demirkol Y, Bailey R, Zhao S, Bohlen J, Mancini M, Seeleuthner Y, Roelens M, Lorenzo L, Soudée C, Paz MEJ, González ML, Jeljeli M, Soulier J, Romana S, L'Honneur AS, Materna M, Martínez-Barricarte R, Pochon M, Oleaga-Quintas C, Michev A, Migaud M, Lévy R, Alyanakian MA, Rozenberg F, Croft CA, Vogt G, Emile JF, Kremer L, Ma CS, Fritz JH, Lemon SM, Spaan AN, Manel N, Abel L, MacDonald MR, Boisson-Dupuis S, Marr N, Tangye SG, Di Santo JP, Zhang Q, Zhang SY, Rice CM, Béziat V, Lachmann N, Langlais D, Casanova JL, Gros P, Bustamante J
Cell 2023 Feb 2;186(3):621-645.e33

E3 ubiquitin ligase RNF6 promotes antiviral immune responses through enhancing the expression of interferon stimulated genes in myeloid cells.

Sun W, Hua X, Gu Y, Xu Q, Zhu S, Lv T, Song Y
Clinical immunology (Orlando, Fla.) 2022 Sep;242:109099

Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas.

Li Y, Goldberg EM, Chen X, Xu X, McGuire JT, Leuzzi G, Karagiannis D, Tate T, Farhangdoost N, Horth C, Dai E, Li Z, Zhang Z, Izar B, Que J, Ciccia A, Majewski J, Yoon AJ, Ailles L, Mendelsohn CL, Lu C
Molecular cell 2022 Oct 20;82(20):3901-3918.e7

Divergent transcriptional regulation of astrocyte reactivity across disorders.

Burda JE, O'Shea TM, Ao Y, Suresh KB, Wang S, Bernstein AM, Chandra A, Deverasetty S, Kawaguchi R, Kim JH, McCallum S, Rogers A, Wahane S, Sofroniew MV
Nature 2022 Jun;606(7914):557-564

Curcumol inhibits EMCV replication by activating CH25H and inhibiting the formation of ROs.

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Upregulation of IRF9 Contributes to Pulmonary Artery Smooth Muscle Cell Proliferation During Pulmonary Arterial Hypertension.

Chen YJ, Li Y, Guo X, Huo B, Chen Y, He Y, Xiao R, Zhu XH, Jiang DS, Wei X
Frontiers in pharmacology 2021;12:773235

A host cell long noncoding RNA NR_033736 regulates type I interferon-mediated gene transcription and modulates intestinal epithelial anti-Cryptosporidium defense.

Li J, Jin K, Li M, Mathy NW, Gong AY, Deng S, Martins GA, Sun M, Strauss-Soukup JK, Chen XM
PLoS pathogens 2021 Jan;17(1):e1009241

The IRENA lncRNA converts chemotherapy-polarized tumor-suppressing macrophages to tumor-promoting phenotypes in breast cancer.

Liu J, Lao L, Chen J, Li J, Zeng W, Zhu X, Li J, Chen X, Yang L, Xing Y, Chen F, Huang D, Zhang X, Wei W, Gong C, Huang S, Yu Z, Li Z, Yang L, Liu J, Liu X, Zheng Q, Meng X, Liang J, Sun L, Zeng M, Li M, Liu Q, Su S, Song E
Nature cancer 2021 Apr;2(4):457-473

Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22.

Zhang M, Fu M, Li M, Hu H, Gong S, Hu Q
Journal of immunology (Baltimore, Md. : 1950) 2020 Sep 1;205(5):1281-1292

Development and validation of an interferon signature predicting prognosis and treatment response for glioblastoma.

Zhu C, Zou C, Guan G, Guo Q, Yan Z, Liu T, Shen S, Xu X, Chen C, Lin Z, Cheng W, Wu A
Oncoimmunology 2019;8(9):e1621677

Mitochondrial DNA Stress Signalling Protects the Nuclear Genome.

Wu Z, Oeck S, West AP, Mangalhara KC, Sainz AG, Newman LE, Zhang XO, Wu L, Yan Q, Bosenberg M, Liu Y, Sulkowski PL, Tripple V, Kaech SM, Glazer PM, Shadel GS
Nature metabolism 2019 Dec;1(12):1209-1218

STAT3 Cooperates With Phospholipid Scramblase 2 to Suppress Type I Interferon Response.

Tsai MH, Lee CK
Frontiers in immunology 2018;9:1886

JAK2 Inhibitor SAR302503 Abrogates PD-L1 Expression and Targets Therapy-Resistant Non-small Cell Lung Cancers.

Pitroda SP, Stack ME, Liu GF, Song SS, Chen L, Liang H, Parekh AD, Huang X, Roach P, Posner MC, Weichselbaum RR, Khodarev NN
Molecular cancer therapeutics 2018 Apr;17(4):732-739

STAT1 and NF-κB Inhibitors Diminish Basal Interferon-Stimulated Gene Expression and Improve the Productive Infection of Oncolytic HSV in MPNST Cells.

Jackson JD, Markert JM, Li L, Carroll SL, Cassady KA
Molecular cancer research : MCR 2016 May;14(5):482-92

Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.

Zhang W, Yin L, Tao X, Xu L, Zheng L, Han X, Xu Y, Wang C, Peng J
Environmental toxicology and pharmacology 2016 Jul;45:193-201

Interferon γ (IFNγ) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses.

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The Journal of biological chemistry 2016 Jan 29;291(5):2389-96

Interferon-stimulated gene factor 3 complex is required for the induction of sterile α motif and HD domain-containing protein 1 expression by interferon-α in SMMC-7721 cells.

Zhu M, Lu J, Dong X, Zheng N, Li T, Chen Z, Pan X, Zhu Y, Yan H, Shen Y, Ying S, Hu C
Molecular medicine reports 2015 Nov;12(5):7176-80

miR-342-5p decreases ankyrin G levels in Alzheimer's disease transgenic mouse models.

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Resistance to oncolytic myxoma virus therapy in nf1(-/-)/trp53(-/-) syngeneic mouse glioma models is independent of anti-viral type-I interferon.

Zemp FJ, McKenzie BA, Lun X, Maxwell L, Reilly KM, McFadden G, Yong VW, Forsyth PA
PloS one 2013;8(6):e65801

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse heart tissue were subjected to SDS PAGE followed by western blot with 14167-1-AP(IRF9 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using IRF9 antibody 14167-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human cervical cancer using 14167-1-AP(IRF9 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human cervical cancer using 14167-1-AP(IRF9 antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue