14167-1-AP

antibody from Proteintech Group

Targeting: IRF9 ISGF3G

Provider product page for 14167-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [24]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 14167-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14167-1-AP, RRID:AB_2296227
Product name: IRF9 antibody
Antibody type: Polyclonal
Description: IRF9 antibody (Cat. #14167-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

IRF9 protein structure - 14167-1-AP shown in red.

Submitted references IFNα-induced BST2(+) tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling.

Zheng C, Wang J, Zhou Y, Duan Y, Zheng R, Xie Y, Wei X, Wu J, Shen H, Ye M, Kong B, Liu Y, Xu P, Zhang Q, Liang T
Cell reports 2024 Apr 23;43(4):114088

Single cell analysis reveals the roles and regulatory mechanisms of type-I interferons in Parkinson's disease.

Quan P, Li X, Si Y, Sun L, Ding FF, Fan Y, Liu H, Wei C, Li R, Zhao X, Yang F, Yao L
Cell communication and signaling : CCS 2024 Apr 2;22(1):212

PTBP2-Mediated Alternative Splicing of IRF9 Controls Tumor-Associated Monocyte/Macrophage Chemotaxis and Repolarization in Neuroblastoma Progression.

Tang J, He J, Guo H, Lin H, Li M, Yang T, Wang HY, Li D, Liu J, Li L, Xia H, Zhuo Z, Miao L
Research (Washington, D.C.) 2023;6:0033

Construction of an interferon regulatory factors-related risk model for predicting prognosis, immune microenvironment and immunotherapy in clear cell renal cell carcinoma.

Pan H, Lu W, Zhang M, Liu C
Frontiers in oncology 2023;13:1131191

Interferon-λ Activates a Differential Response in Peripheral Neurons That Is Effective against Alpha Herpesvirus Infections.

Salazar S, Luong KTY, Nua T, Koyuncu OO
Pathogens (Basel, Switzerland) 2023 Sep 7;12(9)

Interferon inhibits a model RNA virus via a limited set of inducible effector genes.

McDougal MB, De Maria AM, Ohlson MB, Kumar A, Xing C, Schoggins JW
EMBO reports 2023 Sep 6;24(9):e56901

EGR1 functions as a new host restriction factor for SARS-CoV-2 to inhibit virus replication through the E3 ubiquitin ligase MARCH8.

Zhao Y, Sui L, Wu P, Li L, Liu L, Ma B, Wang W, Chi H, Wang Z-D, Wei Z, Hou Z, Zhang K, Niu J, Jin N, Li C, Zhao J, Wang G, Liu Q
Journal of virology 2023 Oct 31;97(10):e0102823

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria.

Rosain J, Neehus AL, Manry J, Yang R, Le Pen J, Daher W, Liu Z, Chan YH, Tahuil N, Türel Ö, Bourgey M, Ogishi M, Doisne JM, Izquierdo HM, Shirasaki T, Le Voyer T, Guérin A, Bastard P, Moncada-Vélez M, Han JE, Khan T, Rapaport F, Hong SH, Cheung A, Haake K, Mindt BC, Pérez L, Philippot Q, Lee D, Zhang P, Rinchai D, Al Ali F, Ahmad Ata MM, Rahman M, Peel JN, Heissel S, Molina H, Kendir-Demirkol Y, Bailey R, Zhao S, Bohlen J, Mancini M, Seeleuthner Y, Roelens M, Lorenzo L, Soudée C, Paz MEJ, González ML, Jeljeli M, Soulier J, Romana S, L'Honneur AS, Materna M, Martínez-Barricarte R, Pochon M, Oleaga-Quintas C, Michev A, Migaud M, Lévy R, Alyanakian MA, Rozenberg F, Croft CA, Vogt G, Emile JF, Kremer L, Ma CS, Fritz JH, Lemon SM, Spaan AN, Manel N, Abel L, MacDonald MR, Boisson-Dupuis S, Marr N, Tangye SG, Di Santo JP, Zhang Q, Zhang SY, Rice CM, Béziat V, Lachmann N, Langlais D, Casanova JL, Gros P, Bustamante J
Cell 2023 Feb 2;186(3):621-645.e33

E3 ubiquitin ligase RNF6 promotes antiviral immune responses through enhancing the expression of interferon stimulated genes in myeloid cells.

Sun W, Hua X, Gu Y, Xu Q, Zhu S, Lv T, Song Y
Clinical immunology (Orlando, Fla.) 2022 Sep;242:109099

Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas.

Li Y, Goldberg EM, Chen X, Xu X, McGuire JT, Leuzzi G, Karagiannis D, Tate T, Farhangdoost N, Horth C, Dai E, Li Z, Zhang Z, Izar B, Que J, Ciccia A, Majewski J, Yoon AJ, Ailles L, Mendelsohn CL, Lu C
Molecular cell 2022 Oct 20;82(20):3901-3918.e7

Divergent transcriptional regulation of astrocyte reactivity across disorders.

Burda JE, O'Shea TM, Ao Y, Suresh KB, Wang S, Bernstein AM, Chandra A, Deverasetty S, Kawaguchi R, Kim JH, McCallum S, Rogers A, Wahane S, Sofroniew MV
Nature 2022 Jun;606(7914):557-564

Curcumol inhibits EMCV replication by activating CH25H and inhibiting the formation of ROs.

Zheng J, Sun P, Sun N, Hao Z, Fan K, Yin W, Khan A, Guo J, Zheng X, Li H
BMC veterinary research 2022 Dec 26;18(1):453

Upregulation of IRF9 Contributes to Pulmonary Artery Smooth Muscle Cell Proliferation During Pulmonary Arterial Hypertension.

Chen YJ, Li Y, Guo X, Huo B, Chen Y, He Y, Xiao R, Zhu XH, Jiang DS, Wei X
Frontiers in pharmacology 2021;12:773235

A host cell long noncoding RNA NR_033736 regulates type I interferon-mediated gene transcription and modulates intestinal epithelial anti-Cryptosporidium defense.

Li J, Jin K, Li M, Mathy NW, Gong AY, Deng S, Martins GA, Sun M, Strauss-Soukup JK, Chen XM
PLoS pathogens 2021 Jan;17(1):e1009241

The IRENA lncRNA converts chemotherapy-polarized tumor-suppressing macrophages to tumor-promoting phenotypes in breast cancer.

Liu J, Lao L, Chen J, Li J, Zeng W, Zhu X, Li J, Chen X, Yang L, Xing Y, Chen F, Huang D, Zhang X, Wei W, Gong C, Huang S, Yu Z, Li Z, Yang L, Liu J, Liu X, Zheng Q, Meng X, Liang J, Sun L, Zeng M, Li M, Liu Q, Su S, Song E
Nature cancer 2021 Apr;2(4):457-473

Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22.

Zhang M, Fu M, Li M, Hu H, Gong S, Hu Q
Journal of immunology (Baltimore, Md. : 1950) 2020 Sep 1;205(5):1281-1292

Mitochondrial DNA Stress Signalling Protects the Nuclear Genome.

Wu Z, Oeck S, West AP, Mangalhara KC, Sainz AG, Newman LE, Zhang XO, Wu L, Yan Q, Bosenberg M, Liu Y, Sulkowski PL, Tripple V, Kaech SM, Glazer PM, Shadel GS
Nature metabolism 2019 Dec;1(12):1209-1218

STAT3 Cooperates With Phospholipid Scramblase 2 to Suppress Type I Interferon Response.

Tsai MH, Lee CK
Frontiers in immunology 2018;9:1886

JAK2 Inhibitor SAR302503 Abrogates PD-L1 Expression and Targets Therapy-Resistant Non-small Cell Lung Cancers.

Pitroda SP, Stack ME, Liu GF, Song SS, Chen L, Liang H, Parekh AD, Huang X, Roach P, Posner MC, Weichselbaum RR, Khodarev NN
Molecular cancer therapeutics 2018 Apr;17(4):732-739

STAT1 and NF-κB Inhibitors Diminish Basal Interferon-Stimulated Gene Expression and Improve the Productive Infection of Oncolytic HSV in MPNST Cells.

Jackson JD, Markert JM, Li L, Carroll SL, Cassady KA
Molecular cancer research : MCR 2016 May;14(5):482-92

Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.

Zhang W, Yin L, Tao X, Xu L, Zheng L, Han X, Xu Y, Wang C, Peng J
Environmental toxicology and pharmacology 2016 Jul;45:193-201

Interferon γ (IFNγ) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses.

Kroczynska B, Rafidi RL, Majchrzak-Kita B, Kosciuczuk EM, Blyth GT, Jemielity J, Warminska Z, Saleiro D, Mehrotra S, Arslan AD, Fish EN, Platanias LC
The Journal of biological chemistry 2016 Jan 29;291(5):2389-96

miR-342-5p decreases ankyrin G levels in Alzheimer's disease transgenic mouse models.

Sun X, Wu Y, Gu M, Zhang Y
Cell reports 2014 Jan 30;6(2):264-70

Resistance to oncolytic myxoma virus therapy in nf1(-/-)/trp53(-/-) syngeneic mouse glioma models is independent of anti-viral type-I interferon.

Zemp FJ, McKenzie BA, Lun X, Maxwell L, Reilly KM, McFadden G, Yong VW, Forsyth PA
PloS one 2013;8(6):e65801

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse heart tissue were subjected to SDS PAGE followed by western blot with 14167-1-AP(IRF9 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using IRF9 antibody 14167-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human cervical cancer using 14167-1-AP(IRF9 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human cervical cancer using 14167-1-AP(IRF9 antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue