14073-1-AP

antibody from Proteintech Group

Targeting: SRPK1 SFRSK1

Provider product page for 14073-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [19]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 14073-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14073-1-AP, RRID:AB_2194745
Product name: SRPK1 antibody
Antibody type: Polyclonal
Description: SRPK1 antibody (Cat. #14073-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SRPK1 protein structure - 14073-1-AP shown in red.

Submitted references Multiple Roles of Protamine Kinase SRPK1 and Phosphatase PP1γ in Sperm Development.

de la Iglesia A, Blanco M, Jodar M, Feudjio O, Leduc M, Castillo J, Cocquet J, Oliva R
Proteomics 2026 Mar 30;:e70121

Transcriptional readthrough precedes alternative splicing programs triggered in CML cells by imatinib.

Podszywałow-Bartnicka P, Shine M, Lin J, Neugebauer KM
Science advances 2026 Mar 20;12(12):eaea2475

IMPDH2 facilitates CD4+ T cell activation through AKT/mTOR pathway by upregulating SRPK1 in myasthenia gravis.

Ren Y, Wu T, Liu Z, Li L, Li Y, Xin G, Peng S, Niu J, Chen B, Cai H, Tian Q, Wang L, Zhang H
Clinical immunology (Orlando, Fla.) 2026 Jan;282:110634

SNW1 promotes lymphatic metastasis in bladder cancer by modulating SRPK1 splicing.

Hu J, Zhu Y, Wang G, Dai H, Han H, Cao W, Ding M, Diao W, Lu Q, Zhang Q, Guo H, Chen W
iScience 2026 Feb 20;29(2):114811

Activation of Nerve Growth Factor signaling limits the response to lenvatinib in hepatocellular carcinoma.

Xu M, Zheng Y, Zhao L, Wang S, Chen J, Fu Z, Ma A, Liang B, Huang Y, Xu H, Wang Y, Ai Y, Zeng H, Gao C, Cai J, Ke A, Fan J
Signal transduction and targeted therapy 2026 Apr 5;11(1)

TREX2 component PCID2 scaffolds alternative SAC3-based subcomplexes with distinct RNA processing and export function.

Aksenova V, Giordano E, Esnault-Petrov C, Arnaoutov A, Dasso M
bioRxiv : the preprint server for biology 2026 Apr 14;

eIF3f promotes tumour malignancy by remodelling fatty acid biosynthesis in hepatocellular carcinoma.

Zhou S, Zhang L, You Y, Yu K, Tie X, Gao Y, Chen Y, Yao F, Zhang R, Hao X, Fang C, Li X, Li Q, Wang X
Journal of hepatology 2025 Sep;83(3):712-728

A novel lncRNA-mediated signaling axis governs cancer stemness and splicing reprogramming in hepatocellular carcinoma with therapeutic potential.

Si K, Zhang L, Jiang Z, Wu Z, Wu Z, Chen Y, Liang W, Zhang X, Zhang W
Journal of experimental & clinical cancer research : CR 2025 Oct 9;44(1):287

SRPK1 Activation Facilitates Gli3(S664) Phosphorylation and Promotes Metastasis in Esophageal Squamous Cell Carcinoma.

Ding Y, Qin J, Zhang M, Wu H, Liu C, Guo Y, Wu W, Jiang Y, Zhang C, Ma Y, Chen X, Lu J, Liu K, Dong Z, Zhao J, Qiao Y
Molecular carcinogenesis 2025 Jul;64(7):1168-1181

SRPK1 facilitates IBDV replication by phosphorylating VP1 at S48.

Zeng Q, Chen Z, Huang Y, Fu Q, Chen Z, Wu H
International journal of biological macromolecules 2025 Feb;291:139002

Post-transcriptional regulation of diabetic wound healing by junctional adhesion molecule A/miR-106b axis.

Gong T, Fan X, Wu M, Chen Z, Xia Z
Burns : journal of the International Society for Burn Injuries 2025 Aug;51(6):107527

SRPK1 is a significant factor in driving the progression of diabetic kidney fibrosis.

Han S, Ma S, Liu K, Qi R, Wang G, Qin W, Zhang X
Diabetology & metabolic syndrome 2025 Aug 6;17(1):316

CDK12-inactivation-induced MYC signaling causes dependency on the splicing kinase SRPK1.

Liang J, Gondane A, Itkonen HM
Molecular oncology 2024 Oct;18(10):2510-2523

LncRNA-LncDACH1 mediated phenotypic switching of smooth muscle cells during neointimal hyperplasia in male arteriovenous fistulas.

Li Z, Zhao Y, Pan Z, Cai B, Zhang C, Jiao J
Nature communications 2024 May 3;15(1):3743

A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins.

Castelli LM, Lin YH, Sanchez-Martinez A, Gül A, Mohd Imran K, Higginbottom A, Upadhyay SK, Márkus NM, Rua Martins R, Cooper-Knock J, Montmasson C, Cohen R, Walton A, Bauer CS, De Vos KJ, Mead RJ, Azzouz M, Dominguez C, Ferraiuolo L, Shaw PJ, Whitworth AJ, Hautbergue GM
Science translational medicine 2023 Mar;15(685):eabo3823

MiR-659-3p inhibits osteosarcoma progression and metastasis by inhibiting cell proliferation and invasion via targeting SRPK1.

Gong Y, Wei ZR
BMC cancer 2022 Aug 29;22(1):934

DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing.

Li Y, Xu J, Lu Y, Bian H, Yang L, Wu H, Zhang X, Zhang B, Xiong M, Chang Y, Tang J, Yang F, Zhao L, Li J, Gao X, Xia M, Tan M, Li J
Cell metabolism 2021 Oct 5;33(10):2004-2020.e9

Clinical and functional significance of CHK1-S, an alternatively spliced isoform of the CHK1 gene, in hepatocellular carcinoma.

Hu G, Wang S, Wang Y, Gao Y, Zhu H, Liu M, Xu N, Wang L
Journal of Cancer 2020;11(7):1792-1799

Novel RNA-Affinity Proteogenomics Dissects Tumor Heterogeneity for Revealing Personalized Markers in Precision Prognosis of Cancer.

Wang L, Wrobel JA, Xie L, Li D, Zurlo G, Shen H, Yang P, Wang Z, Peng Y, Gunawardena HP, Zhang Q, Chen X
Cell chemical biology 2018 May 17;25(5):619-633.e5

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Jurkat cells were subjected to SDS PAGE followed by western blot with 14073-1-AP(SRPK1 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SRPK1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SRPK1. This antibody recognizes human,mouse,rat antigen. The SRPK1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 14073-1-AP.pdf

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