Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 15831-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15831-1-AP, RRID:AB_2294385
- Product name
- GARS antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated GARS antibody (Cat. #15831-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references SIRT2-knockdown rescues GARS-induced Charcot-Marie-Tooth neuropathy.
The tRNA-like small noncoding RNA mascRNA promotes global protein translation.
HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease.
Mutations in glycyl-tRNA synthetase impair mitochondrial metabolism in neurons.
Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases.
Zhao Y, Xie L, Shen C, Qi Q, Qin Y, Xing J, Zhou D, Qi Y, Yan Z, Lin X, Dai R, Lin J, Yu W
Aging cell 2021 Jun;20(6):e13391
Aging cell 2021 Jun;20(6):e13391
The tRNA-like small noncoding RNA mascRNA promotes global protein translation.
Lu X, Huang J, Wu S, Zheng Q, Liu P, Feng H, Su X, Fu H, Xi Q, Wang G
EMBO reports 2020 Dec 3;21(12):e49684
EMBO reports 2020 Dec 3;21(12):e49684
HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease.
Benoy V, Van Helleputte L, Prior R, d'Ydewalle C, Haeck W, Geens N, Scheveneels W, Schevenels B, Cader MZ, Talbot K, Kozikowski AP, Vanden Berghe P, Van Damme P, Robberecht W, Van Den Bosch L
Brain : a journal of neurology 2018 Mar 1;141(3):673-687
Brain : a journal of neurology 2018 Mar 1;141(3):673-687
Mutations in glycyl-tRNA synthetase impair mitochondrial metabolism in neurons.
Boczonadi V, Meyer K, Gonczarowska-Jorge H, Griffin H, Roos A, Bartsakoulia M, Bansagi B, Ricci G, Palinkas F, Zahedi RP, Bruni F, Kaspar B, Lochmüller H, Boycott KM, Müller JS, Horvath R
Human molecular genetics 2018 Jun 15;27(12):2187-2204
Human molecular genetics 2018 Jun 15;27(12):2187-2204
Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases.
Niehues S, Bussmann J, Steffes G, Erdmann I, Köhrer C, Sun L, Wagner M, Schäfer K, Wang G, Koerdt SN, Stum M, Jaiswal S, RajBhandary UL, Thomas U, Aberle H, Burgess RW, Yang XL, Dieterich D, Storkebaum E
Nature communications 2015 Jul 3;6:7520
Nature communications 2015 Jul 3;6:7520
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 15831-1-AP(GARS antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using GARS antibody 15831-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human skin cancer using 15831-1-AP(GARS antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue