Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [1374]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 17168-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17168-1-AP, RRID:AB_2716755
- Product name
- Histone-H3 antibody
- Antibody type
- Polyclonal
- Description
- Histone-H3 antibody (Cat. #17168-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 150ul
Submitted references Abnormal mechanical load aggravates subchondral bone remodeling and uneven tibial plateau settlement in knee osteoarthritis via activation of osteoblast Piezo1-Ca²⁺-JAK2/STAT3 signaling.
Schisandrin B Targets PXR to Enhance Bile Acid Metabolism and Alleviate ANIT-Induced Cholestatic Liver Injury via Dual Pathways.
EP300/YAP1-SERPINE1 Signaling Regulates Ductular Reaction and Liver Fibrosis in Biliary Atresia.
Xiaoyao San alleviates emotional distress - induced TNBC growth through augmenting intratumoral CD8(+)T cell infiltration mediated by Rela/NF-kB-Cxcl9 axis.
A putative prognostic model for lung adenocarcinoma based on crotonylation-related genes by bioinformatics and experimental verification.
Characteristics of Exosomes and Microbiota in the Decidua of Patients With Early Pregnancy Loss and Their Impact on Trophoblast Cells.
Dual function of DOT1L suppresses tumor cell-intrinsic immunogenicity in hepatocellular carcinoma.
Identification of STMN1 as a lactylation‑related driver of lung cancer progression using Mendelian randomization.
miR-221 Mediates the Regulation of Phospholamban Expression and Cardiac Contractility by ZBTB20.
HnRNP C binding to inverted Alu elements protects the transcriptome from pre-mRNA circularization.
NUP62 promotes breast cancer progression and inhibits ferroptosis by stabilizing NRF2 in a KEAP1-dependent way.
Hypoxia-driven phase separation of the PABP1/eIF4B complex forms stress granules and activates ChaC2 translation to promote polyunsaturated lipids-supported peritoneal metastasis in gastric cancer.
m6A deficiency induces dopaminergic neurodegeneration and progressive parkinsonism through a pathogenic loop with mitochondria.
AARS1-mediated lactylation of H3K18 and STAT1 promotes ferroptosis in diabetic nephropathy.
Restricting Synaptotagmin-3 Internalization Mitigates Cerebral Ischemia/Reperfusion Injury by Curtailed Neuronal Apoptosis and Microglial Re-Programming.
Nanog mediated control of TBX3-GATA6 circuitry in primitive endoderm differentiation of mESCs.
Dextrorotatory kynurenine suppresses acute rejection through inhibiting M1 macrophage-mediated inflammation.
Multi-omics mapping identifies CYBA-mediated mitochondrial dysfunction driving macrophage polarization and ferroptosis via Nrf2 pathway in atherosclerosis.
NPM3 functions as a lactyltransferase to promote necroptosis in male diabetic cardiomyopathy mice models via FASN transcription modulation.
Intracellular complement Factor H promotes tumor progression through modulation of cell cycle and actin cytoskeleton.
TFAP2A regulates SGPP2 transcription to promote lipid accumulation and activate the Wnt/β-catenin signaling pathway to promote malignant progression in lung adenocarcinoma.
EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS-STING Pathway.
Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated mitophagy.
Chemotherapy-induced senescent nasopharyngeal carcinoma cells suppress NK cell-mediated antitumor immunity by upregulating EBI3 via mtDNA-cGAS-STING pathway.
Pharmaco-genomic characterization of pancreatic and biliary tract cancer tumoroids for drug response.
VISTA promotes ovarian cancer progression through activation of NF-κB pathway and tumor microenvironment reprogramming.
H3K9me2 is a determinant for the mitosis-to-meiosis transition in female germ cells.
H3K27me3-mediated chromatin remodeling governs salt tolerance in cotton via Na(+)/K(+) homeostasis modulation.
CD93-targeted resveratrol-loaded PLGA nanoparticles remodel CD8⁺ T cell metabolism through AIF-mediated oxidative phosphorylation to overcome lung cancer immunotherapy resistance.
CXCL12 Promotes Peripheral Nerve Injury Repair by Inhibiting the Ferroptosis-Inflammation Axis via the ERK/Nrf2 Pathway.
Synergistic Anti-Tumor Activity of LRPPRC Inhibition and Dasatinib Through Dual Oxidative Phosphorylation Disruption.
S100A11 regulates microglial inflammatory response in neuropathic pain via H3K27ac-TFEB-mitochondrial autophagy axis.
ACSS2-mediated lysine crotonylation attenuates senescence and enhances the therapeutic efficacy of adipose-derived stem cells in inflammatory bowel disease.
Membrane-camouflaged nanoparticle alleviates intervertebral disc degeneration via oxidative stress suppression and autophagy activation.
Prostaglandin F2α impairs skin regeneration via FP receptor-mediated oxidative stress overriding autophagic protection in fibroblasts.
Sijunzi decoction alleviates cancer cachexia myatrophy by suppressing M2 polarization of tumor-associated macrophages via the MCT1/lactate/H3K18 lactylation pathway.
HnRNP H1 binds to nucleocapsid protein and potential guanine-quadruplex site of viral RNA to promote PRRSV-2 proliferation.
Metformin attenuates colitis via blocking STAT3 acetylation by reducing acetyl-CoA production.
Transcriptional condensates enrich phosphorylated PRMT2 to stimulate H3R8me2a deposition and hypoxic response in glioblastoma.
An ATP-gated molecular switch orchestrates human mRNA export.
S-phase PARylation of microprotein RSMC enhances the function of Sororin in sister chromatid cohesion.
Complement C3a Suppresses Spinal Cord Neural Stem Cell Activation by Inhibiting UCHL1 via the NF-κB p65/Nrf2 Pathway.
Transdermal delivery of salvianolic acid B using thermosensitive hydrogel for the treatment of skin photoaging.
A bioactive protein from Dioscorea polystachya residue alleviates hydrocortisone-induced erectile dysfunction in rats via TXNIP/NLRP3 pathway inhibition.
ABCC10-mediated cGAMP efflux drives cancer cell radiotherapy resistance.
Metabolic and epigenetic abnormalities cause hepatic fibrogenesis in metabolic dysfunction-associated steatohepatitis model mice.
Histone H4K8 lactylation modulated immunosuppressive properties by promoting FAP transcription and ECM remodeling.
20-hydroxyecdysone promotes brain development via upregulating MMP2 expression during metamorphosis in Helicoverpa armigera.
Periplocin and bufalin induce cardiotoxicity by regulating AMPK/SIRT1/PGC-1α pathway to inhibit energy metabolism and trigger autophagy.
Safranal accelerates diabetic wound healing by suppressing ferroptosis through modulation of transcription factor Forkhead Box O3.
HDAC6 orchestrates metastatic and immunosuppressive programs in small cell lung cancer through S100A2-TGF-β/SMAD and CSF1R signaling.
Dictamnine inhibited keratinocyte hyperproliferation and alleviated psoriasis-like dermatitis via blocking HIF1A-mediated ferroptotic pathway.
Autocatalytic Signal Amplification via Orthogonal Recognition of Dual Proteins on the Surface of Serum Extracellular Vesicles for Precise Diagnosis of Prostate Cancer.
The GC-derived exosomal LncRNA DARS-AS1 activates Wnt/β-catenin pathway to drive angiogenesis by regulating miR-605-5p/BCL9.
Betaine Inhibits Ferroptosis After Intracerebral Hemorrhage by Activating the Nrf2/HO-1 Pathway.
Defining the Critical Role of α-Gustducin for NF-κB Inhibition and Anti-Inflammatory Signal Transduction by Bitter Agonists in Lung Epithelium.
Narciclasine Alleviates Endothelial Inflammation and Atherosclerosis Initiation by Inhibiting Histone Lactylation-Mediated NF-κB Activation.
Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity.
O-GlcNAcylation of NONO mediates alternative splicing of SETMAR and facilitates NHEJ repair.
Wnt3a promotes in situ dentin formation through NKD1-MSX1 axis-mediated odontogenic differentiation of dental pulp stem cells.
Promoting the nuclear retention of HMGB1 attenuates astrocyte senescence.
T-2 toxin exacerbates chondrocyte extracellular matrix degradation potentially through YAP/NLRP3/GSDMD-mediated pyroptosis.
SA supplementation during lactation promotes learning and memory by reducing H3K27me3 levels.
PXR ribosylation at E194 amplifies NAPQI in acetaminophen‒induced liver injury in mice, rescued by Schisandrin B.
Intranasal delivery of Odorranalectin-modified lipid nanoparticles for multi-targeted therapy of Alzheimer's disease.
Mechano-matching hydrogel patch promotes myocardial infarction repair via YAP-Bcl-2 pathway activation.
Intestinal metabolite TMAO promotes CKD progression by stimulating macrophage M2 polarization through histone H4 lysine 12 lactylation.
Cell death modulation dictates tissue-specific tropism of lumpy skin disease virus.
Endothelium-Treg Communication Through Extracellular Vesicle Transfer Exacerbates Acute Respiratory Distress Syndrome.
COL1A1 promotes clear cell renal cell carcinoma progression through the Wnt/β-catenin signaling pathway.
Icaritin Ameliorates Cisplatin-Induced Mitochondrial Metabolic Dysfunction-Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy.
Histone lactylation increases CXCL1 expression for neutrophil infiltration and immune escape in pancreatic cancer.
HSPA5 promotes YAP/TAZ stability independently of the Hippo pathway and induces proneural-to-mesenchymal transition in glioblastoma.
Cuproptosis promotes inflammatory osteolysis via GYS1-mediated glycogen metabolism.
The Mislocalization of TDP-43 to Mitochondria Impairs Myotube Maturation.
Lactate Promotes Endothelial-Mesenchymal Transition via Mediating Twist1 Lactylation in Hypoxic Pulmonary Hypertension.
Matrix Metalloproteinase 7 Mediates Epithelial-Mesenchymal Transition to Promote Liver Fibrosis Through E-cadherin/β-catenin Pathway in Biliary Atresia.
A novel molecule ZYZ329 targeting histone methyltransferase SMYD3 suppresses pathological angiogenesis via the driven mitochondrial ROS/HIF-1α/VEGFA axis.
Alpha-Ketoglutarate Drives an Osteogenic and Extracellular Matrix Gene Program in Periodontal Ligament Fibroblasts via Selective Reduction of H3K27me3.
Nicotinamide Mononucleotide Decreases Secretion of Proinflammatory Cytokines via the NAD (+) /SIRT1/p65 Axis.
PDHA1-acetylation signaling suppresses cuproptosis to attenuate anti-androgen effect in prostate cancer.
Aurkb deficiency disrupts microglial development, homeostasis and hinders remyelination following cuprizone-induced demyelination.
Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer's disease pathogenesis.
Disruption of FGL2 induces TFEB-dependent lysosomal degradation of PD-L1 and enhances the efficacy of anti-PD1 therapy in hepatocellular carcinoma.
Apoptotic vesicles from endothelial cells promote endothelial progenitor cell differentiation and angiogenesis via miR-30a-5p mediated activation of the EGFR/PI3K/AKT/VEGF pathway.
Targeting AARS1-dependent lactylation improves neuronal process plasticity and mitigates cognitive deficits in sepsis-associated encephalopathy.
Discovery of CZL-077 as a potent, selective, and orally active p300/CBP bromodomain inhibitor with improved in vivo antitumor efficacy.
KIF20A inhibits TRIM21-dependent ubiquitination of DHX9 to boost SOX2 stability, enhancing OSCC stemness and ferroptosis resistance.
Structural characterization and anti-hepatic fibrosis effects of a novel polysaccharide from Astragalus complanatus seeds.
EP300 attenuates ferroptosis and stimulates proliferation, migration, and fibrosis of keloid fibroblasts via YY1/GPX4 axis.
Apolipoprotein C3 exacerbates vascular calcification by promoting ferroptosis via the TLR2/AMPK pathway in vascular smooth muscle cells.
An intelligent nanoliposome alleviates disc degeneration and discogenic pain by inhibiting neurovascular ingrowth via a "Soil-conditioning, seed-modulating, and weeds-suppressing" strategy.
HMGA2 promotes hepatocellular carcinoma progression by regulating tumor-associated macrophage via Notch1/CCL2 signaling.
Electroacupuncture regulates neuronal ferroptosis and ferritinophagy through lysosomal-mediated TFEB activation in cerebral ischemia-reperfusion.
PMM2 interacts with TRIM28 to recruit E2F4 and promote KIFC3-mediated tumor glycolysis and colorectal cancer progression.
YAP Regulates Microglial Anti-Inflammatory Responses and Alleviates Cognitive Impairment Through the IL-33/ST2 Pathway after Traumatic Brain Injury.
Multifunctional hydrogel delivery of mesenchymal stem cell secretome suppresses neutrophil extracellular trap formation and promotes diabetic wound healing via PGE2/BMAL1 pathway.
ANGPT2/Tie2 Enhances H3K18la-Mediated Macrophage M2 Polarization to Promote Endothelial Cell Proliferation in the Chronically Ischaemic Brain.
ANKRD62 Modulates NF-κB Signaling to Promote Proliferation and Migration in UCEC.
Ascites circRNA ASCOR Drives Platinum Resistance of High-Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation.
Identification of A p300-SP1-BRD4 Transcriptional Axis as a Key Driver of AR Hyperactivation in Polycystic Ovarian Syndrome.
Discovery of p300 histone acetyltransferase inhibitors bearing an imidazo[4,5-b]pyridine-2-one scaffold for the treatment of multiple myeloma.
Mechanisms of Mechanical Stress-Induced Vascular Remodeling via the Lactate-PKM2 Axis and Implications for Microgravity Adaptation.
Free Nε-(carboxymethyl)-lysine promotes diabetic kidney disease progression via RAGE/NF-κB/NLRP3 pathway-mediated podocyte PANoptosis.
Engineered CAR-monocytes coordinate fibrosis clearance and cardiac regeneration following myocardial infarction.
Porcine hemagglutinating encephalomyelitis virus nucleocapsid protein targets RIG-I and IRF3 to evade IFN immunity.
LENG8 mediates RNA nuclear retention and degradation in eukaryotes.
Transcription Factor StHRAV1 Negatively Regulates Thermotolerance by Modulating ROS Accumulation in Potato.
LTF regulates glioblastoma progression and temozolomide resistance via the NF-κB signaling pathway.
PGC-1α agonist ZLN005 ameliorates OVA-induced asthma in BALB/c mice through modulating the NF-κB-p65/NLRP3 pathway.
Sulforaphane alleviates membranous nephropathy by inhibiting oxidative stress-associated podocyte pyroptosis.
Metformin Alleviates Liver Metabolic Dysfunction in Polycystic Ovary Syndrome by Activating the Ethe1/Keap1/PINK1 Pathway.
β-estradiol alleviates hypoxic-ischemic brain damage in neonatal rats through the GPER1-mediated AKT/NF-κB signaling pathway.
FKBP10 Promotes the Muscle Invasion of Bladder Cancer via Lamin A Dysregulation.
TERT translocation as a Novel condition in Intrauterine Growth Restriction rats with early catch-up growth.
Chlorogenic acid inhibits NLRP3 inflammasome activation through Nrf2 activation in diabetic nephropathy.
A Peptide Encoded by lncRNA HOXB-AS3 Promotes Cigarette Smoke-Induced Inflammation in Bronchial Epithelial Cells via EZH2-Mediated H3K27me3 Modification.
Liver-specific Bcl3 Knockout Alleviates Acetaminophen-induced Liver Injury by Activating Nrf2 Pathway in Male Mice.
Lobetyolin Suppressed Osteoclastogenesis and Alleviated Bone Loss in Ovariectomy-Induced Osteoporosis via Hindering p50/p65 Nuclear Translocation and Downstream NFATc1/c-Fos Expression.
Unveiling the Novel Anti - Tumor Potential of Digitonin, a Steroidal Saponin, in Gastric Cancer: A Network Pharmacology and Experimental Validation Study.
Remimazolam Suppresses Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury by Regulating AKT/GSK-3β/NRF2 Pathway.
Effects of ADRM1 on osteoblast differentiation and mineralization in osteoporosis.
COL6A2 drives clear cell renal cell carcinoma progression via integrin-dependent modulation of Wnt/β-catenin signaling.
NETs drive myocardial fibrosis in hypertension via an NF-κB/ferroptosis axis.
GDF15 orchestrates mitochondrial-immune crosstalk via SMAD7-HIF-1α-PKM2 cascade to attenuate septic liver injury.
Treatment With Schistosoma Japonicum Peptide SJMHE1 and SJMHE1-Loaded Hydrogel for the Mitigation of Psoriasis.
Histone lactylation exacerbates acute lung injury in septic mice by promoting ferroptosis in pulmonary microvascular endothelial cells.
Flufenamic acid inhibits pyroptosis in ischemic flaps via the AMPK-TRPML1-Calcineurin signaling pathway.
Protosappanin A protects against pathological cardiac hypertrophy by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis via activation of the Nrf2 signaling pathway.
Calycosin inhibits porcine reproductive and respiratory syndrome virus replication and activates RIG-I/IRF3 signaling pathway.
Nutrients regulation of skin cells from canines and cats via Wnt/β-catenin signaling pathway.
Sestrin2 Regulates Mitochondrial Function and Autophagy via Nrf2/SIRT3 Signaling to Ameliorate Hypoxia/Reoxygenation-Induced Rat's Cardiomyocyte Injury.
KDM4C regulates trophoblast proliferation and migration in preeclampsia via the NFATc4/Wnt pathway.
Benserazide‑mediated targeting hexokinase 2 enhances the cytotoxicity of cisplatin in non-small cell lung cancer cell models.
IFITM1 promotes proliferation, migration and macrophage-like transdifferentiation of vascular smooth muscle cells via c-Src/MAPK/GATA2/E2F2 pathway in atherosclerosis.
Alexidine dihydrochloride enhances the sensitivity of human hepatocellular carcinoma to disulfidptosis via ATF4-DDIT3 activation.
Regulatory role of ATF2 in trophoblast ferroptosis via the PI3K/Akt/Nrf2 pathway in gestational diabetes mellitus.
Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone-Glucocorticoid Receptor-LAMA5 Axis.
Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia-Reperfusion Injury.
LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma.
Topoisomerase I Inhibition in ETV4-overexpressed Non-Small Cell Lung Cancer Promotes Replication and Transcription Mediated R-Loop Accumulation and DNA Damage.
A Novel Nuclear-Localized Micropeptide, MP60, Promotes Hepatocellular Carcinoma Progression via the Epithelial-Mesenchymal Transition.
Epigenetic reprogramming of HDAC2 in CA1 excitatory neurons determines Pb-induced non-spatial memory deficits.
Ipriflavone Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection via RIG-I/IRF3-Mediated Interferon Signaling.
IRS2/FOXO1 mitigates osteoarthritis by regulating chondrocyte autophagy and mitochondrial function.
TRIM21 promotes colorectal cancer development through regulating DNA replication by TCF3/MCM2/5 axis.
C19orf12 inhibits mitochondrial function and enhances the antitumor effects of metformin in non-small cell lung cancer.
Fluzoparib disrupts Golgi apparatus to inhibit O-GlcNAcylation and nuclear translocation of β-catenin to attenuate ovarian cancer invasion and metastasis.
Uncovering the Anti-Atherosclerotic Effect of Isoquercitrin via Microbiome Metabolic Modulation and Network Pharmacology.
FOXO3 Protects Lens Epithelial Cells From UVB-Induced Oxidative Stress via the AMPK/FOXO3 Signaling Pathway.
Design and synthesis of CDK9/EZH2 dual-target inhibitors to achieve synergistic antitumor effects.
The Outer Membrane Protein Tp92 of Treponema pallidum Induces BeWo Cells Apoptosis and Oxidative Stress via the Nrf2/keap1 Pathway.
Aberrant WDR5 promotes the progression of cervical cancer through the YAP1- CTGF pathway.
Arsenic-induced hepatotoxicity: Mechanistic insights into TNFAIP3-mediated regulation of the NF-κB p65/IAPs Signaling Pathway.
Early-life ketone body signalling promotes beige fat biogenesis through changes in histone acetylome and β-hydroxybutyrylome.
SFRS8 Regulates Memory by Modulating RNA Splicing of Synaptic Genes.
4-Octyl Itaconate Attenuates Postmenopausal Osteoporosis by Inhibiting Ferroptosis and Enhancing Osteogenesis via the Nrf2 Pathway.
OTUD1 downregulates PD-L1 expression by deubiquitinating STAT3 and promotes the immune response in ccRCC.
Dapagliflozin ameliorates high glucose-induced epithelial-mesenchymal transition via up-regulating ACE2 mediated by EZH2 in diabetic nephropathy.
HOMER3 orchestrates SRC-YAP1 activity that promotes tumor cell growth and antagonizes anti-tumor immunotherapy in prostate cancer.
The SLCO4A1-Mediated Transmembrane Transport of Lysionotin Attenuates Acute Lung Injury Through Activating the AMPK/Nrf2 Signaling Pathway.
The long noncoding RNA SNHG12 defines KEAP1 stability and ferroptosis susceptibility by targeting E3 ligase TRIM25.
METTL3-dependent m(6)A modification of SNAP29 induces "autophagy-mitochondrial crisis" in the ischemic microenvironment after soft tissue transplantation.
Liraglutide suppresses ferroptosis by upregulation NRF2 in type 2 diabetic cardiomyopathy.
MitoQ for vitiligo by mitigating PARP1 translocation aberrations: Network pharmacology and experimental validation.
Impact of gut microbiome on radiotherapy and immunotherapy efficacy in microsatellite-stable colorectal cancer: role of propionic acid and B. fragilis.
EP300-interacting inhibitor of differentiation 3 is required for spermatogenesis in mice.
PBAF/cBAF reorganization on H3.3 chromatin regulates BMAL1 activity in the absence of circadian negative feedback.
Identification of human RNA Polymerase II interactors at early stages of transcription.
Hippocampal CaMKII-α β-hydroxybutyrylation induces memory deficits in mice with type 1 diabetes mellitus.
LncRNA-like MMP14 RNA facilitates colorectal cancer metastasis by suppressing H3K27cr at the STARD13 promoter region.
KAT2A-H3K79succ-Mediated SH2B3 Upregulation Promotes TNBC Metastasis Through Diminishing the Ubiquitin-Dependent Degradation of Vimentin.
CFDP1 is required for histone variant H2A.Z deposition by the human SRCAP chromatin remodeling complex.
IgD in nucleus of pro-B cells promotes pro-B cells proliferation by regulating E2F3 expression.
Helicobacter pylori VacA modulates TRAF1-mediated 4-1BB/NF-kappaB axis to induce host apoptosis and chronic inflammatory damage.
Ginsenoside Ro Targets BCAT1/2 to Suppress Ferroptosis: A Novel Therapeutic Strategy for Ischemic Cardioprotection.
TDP-43 dysfunction leads to impaired proteostasis and predisposes mice to worse neurological outcomes after brain injury.
Linking the production of reactive oxygen species to the expression of antimicrobial peptides through aquaporin in an arthropod.
Sodium nitrate protects against metabolic syndrome by sialin-mediated macrophage rebalance.
Targeting PURPL RNA enabled rejuvenation of senescence cells via epigenetic reprogramming.
SAP30BP aggravates mitochondrial-related ferroptosis in diabetic cardiomyopathy by regulating MFN2-ACSL4 axis.
Characterization of Corneal Defects in ATG7-Deficient Mice.
Nano-Self-Assembled Particles Loaded with Aldehyde Dehydrogenase 2 Agonist Inhibit Ischemia-Reperfusion Injury of Transplanted Kidneys.
Engineered extracellular vesicles for targeted FGF20 delivery enhance neuroplasticity and functional recovery in ischemic stroke.
H3K18 lactylation in cancer-associated fibroblasts drives malignant pleural effusion progression via TNFR2(+) T(reg) recruitment.
Lactate Prevents Glucose Deprivation-Induced Parthanatos in Gastric Cancer Cells Through Alleviating Intracellular Reactive Oxygen Species.
Acteoside-containing caffeic acid is bioactive functional group of antifibrotic effect by suppressing inflammation via inhibiting AHR nuclear translocation in chronic kidney disease.
SENP3 Promotes Hepatocyte Steatosis via De-SUMOylation of SREBP2.
Quercetin Targets HSP90α and Regulates Keap1/Nrf2 Pathway to Inhibit Crosstalk between Apoptosis and Ferroptosis in Oxidatively Stressed Neurons.
AMPK upregulates SOCS1 to promote TFEB nuclear transfer, enhances autophagy, inhibits macrophage M1 polarization and relieves acute lung injury.
Protocatechuic aldehyde promotes diabetic wound healing by enhancing angiogenesis via H3K18 lactylation-mediated Acvr1c expression.
A Novel EYA1 Splicing Mutation in a Chinese Family With Branchio-Oto Syndrome: A Functional Analysis and Reproductive Intervention.
CLOCK promotes proliferation of glioblastoma cells through acetylating PRPS1/2.
Histone Lactylation-Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells.
EGFR Targeted Liposomal PROTAC Assisted With Epigenetic Regulation as an Efficient Strategy for Osimertinib-Resistant Lung Cancer Therapy.
TGFB2/IGFBP5 activated by transcription factors STAT2 and SMAD3 initiate granulosa cell degeneration and cause follicular atresia in chickens.
Hydrogen activated the Nrf2/HO pathway to alleviate the cognitive decline in PD Drosophila after long-term sevoflurane exposure.
Dexmedetomidine alleviates ferroptosis caused by traumatic brain injury via the NRF2/HO-1/GPX4 pathway.
Histone H3K18 lactylation-dependent epigenetic activation of RUNX2 orchestrates PI3K/AKT oncogenic signaling in laryngeal squamous cell carcinoma.
Neutrophil extracellular traps-STC1 positive feedback loop promotes immune evasion and metastasis in bladder cancer.
The Frog Skin-Derived Antimicrobial Peptide Suppresses Atherosclerosis by Modulating the KLF12/p300 Axis Through miR-590-5p.
Pulchinenoside E2: A dual-functional STAT3 and autophagy inhibitor with potent anti-metastatic activity in triple-negative breast cancer.
Rosmarinic acid alleviates doxorubicin-induced cellular senescence and cardiotoxicity by targeting the 14-3-3/Foxo1 signaling axis.
Biochanin A alleviates endothelial cell senescence via epigenetic regulation of the HDAC1/H3K4me3/NFKB1 axis.
PURA protein mislocalisation in the nucleus: mechanistic basis for transcriptional dysregulation and DNA unwinding deficits in a model of the p.L148Wfs*77 PURA variant.
Multi-omics analysis of the HMGB2(+) tumor epithelial cells in lactylation subgroups in colorectal cancer.
Pyruvate kinase M2 -mediated histone lactylation alters three-dimensional genomic architecture in polycystic ovary syndrome.
Luteolin protects against alcoholic liver injury by restoring NRF2 stability to suppress ACSS2 nuclear accumulation.
BRD4 inhibition suppresses histone H4 UFMylation to increase ferroptosis sensitivity through TXNIP.
Molecular basis for CSB stimulation of the SNM1A DNA repair nuclease.
Truncated APC impairs innate immune response by targeting MAVS on mitochondria in colorectal cancer.
The N-terminal region of HASPIN regulates phosphorylation of AURKA and meiotic progression in spermatocytes.
DHYZ modulates hippocampal cholinergic pathway acetylation to ameliorate cognitive deficits post-ischemic stroke in rats.
Phospho-TRIM21 orchestrates RPA2 ubiquitination switch to promote homologous recombination and tumor radio/chemo-resistance.
N-Acety-L-Cysteine Alleviates Isoflurane-Triggered Neuronal Cell Parthanatos by Suppressing Reactive Oxygen Species Accumulation Through the Induction of c-Jun N-Terminal Kinase Signaling Pathway Inhibition.
Macelignan Improves Functional Recovery After Spinal Cord Injury by Augmenting Autophagy via the AKT-mTOR-TFEB Signaling Pathway.
HDAC6 inhibition upregulates endothelial SOD3 expression via Sp1 acetylation and attenuates angiotensin II-induced hypertension.
Cardiac PDK4 promotes neutrophilic PFKL methylation and drives the innate immune response in diabetic myocardial infarction.
UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling.
Targeting COPA to Enhance Erdafitinib Sensitivity in FGFR-Altered Bladder Cancer.
Tumor cell-intrinsic circular RNA circFNDC3B attenuates CD8(+) T cells infiltration in non-small cell lung cancer.
Transglutaminase 2 nuclear localization enhances glioblastoma radiation resistance.
hnRNPL phase separation activates PIK3CB transcription and promotes glycolysis in ovarian cancer.
Synergistic regulation of DACH1 stability by acetylation and deubiquitination promotes colorectal cancer progression.
NSUN2-mediated HCV RNA m5C Methylation Facilitates Viral RNA Stability and Replication.
ZBP1 senses splicing aberration through Z-RNA to promote cell death.
Phase separation of MRG15 delays cellular senescence.
The differential impact of HNRNPA1 isoforms on gene expression and their relevance to dsRNA-mediated innate immune response.
Histone demethylase LSD1 promotes castration-resistant prostate cancer by causing widespread gene expression derangements.
Targeting Hsp90α to inhibit HMGB1-mediated renal inflammation and fibrosis.
Pleiotrophin Prevents H(2)O(2)-Induced Senescence of Dental Pulp Stem Cells.
ISRIB facilitates post-spinal cord injury recovery through attenuation of neuronal apoptosis and modulation of neuroinflammation.
H(2)S Donor SPRC Ameliorates Cardiac Aging by Suppression of JMJD3, a Histone Demethylase.
Aldehyde dehydrogenase 2 attenuates renal injury through inhibiting CYP4A expression.
Early intervention with pericyte Fli-1 post-TBI attenuates hippocampal BBB disruption and subsequent neuroinflammation with neurological deficits.
Ubiquitin-specific peptidase 10 promotes renal interstitial fibrosis progression through deubiquitinating and stabilizing P53 protein.
Tumor exosomal RNPEP promotes lung metastasis of liver cancer via inducing cancer-associated fibroblast activation.
Neutrophil-derived heparin-binding protein increases endothelial permeability in acute lung injury by promoting TRIM21 and the ubiquitination of P65.
Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness.
Photoinduced Actin Aggregation Involves Cell Death: A Mechanism of Cancer Cell Cytotoxicity after Near-Infrared Photoimmunotherapy.
BRD4 Mediates Cadmium-Induced Oxidative Stress and Kidney Injury in Mice via Disruption of Redox Homeostasis.
20-hydroxyecdysone via upregulating 4EBP expression and inhibiting its phosphorylation represses cell proliferation to permit insect larval molting.
Baicalein Ameliorates Experimental Ulcerative Colitis Recurrency by Downregulating Neonatal Fc Receptor via the NF-κB Signaling Pathway.
Mechanism of ASF1 engagement by CDAN1.
Neuroprotective effect of apo-9'-fucoxanthinone against cerebral ischemia injury by targeting the PI3K/AKT/GSK-3β pathway.
NNMT promotes acquired EGFR-TKI resistance by forming EGR1 and lactate-mediated double positive feedback loops in non-small cell lung cancer.
iPSC-derived cardiomyocytes and engineered heart tissues reveal suppressed JAK2/STAT3 signaling in LMNA-related emery-dreifuss muscular dystrophy.
Tyrosine and Phenylalanine Activate Neuronal DNA Repair but Exhibit Opposing Effects on Global Transcription and Adult Female Mice Are Resilient to TyrRS/YARS1 Depletion.
Tryptophan Metabolic Enzyme IL4I1 Inhibits Ferroptosis by Decreasing Ubiquitination of Nrf2 via I3P in Glioblastoma.
5-HT(7)R Deficiency Alleviates ADP-Heptose-Induced Cognitive Impairment via Inhibiting Ferroptosis and Neuroinflammation in Mice.
CuATSM Enhances Wound Repair Without Scarring via Hippo/YAP Signalling Pathway to Reduce Ferroptosis and Macrophage Polarisation.
Rotenone adaptation promotes migration and invasion of p53-wild-type colon cancer through lipid metabolism.
Spatial alteration of metabolites in diabetic cortical cataracts: New insight into lactate.
Glabridin ameliorates hemorrhagic shock induced acute kidney injury by activating Nrf2/HO-1 pathway.
Neferine reduces synovial inflammation and cardiac complications in a collagen-induced arthritis mouse model via inhibiting NF-κB/NLRP3 inflammasome axis.
OsPPR8, a pentatricopeptide repeat protein, regulates splicing of mitochondrial nad2 intron 3 to affect grain quality and high-temperature tolerance in rice.
Mitochondrial oxidative stress inhibited Sirt3/Foxo3/PPARα pathway and aggravated copper and zinc co-deficiency-induced hepatic lipotoxicity in a fish model.
Elevated phenylacetylglutamine caused by gut dysbiosis associated with type 2 diabetes increases neutrophil extracellular traps formation and exacerbates brain infarction.
O-GlcNAcylation-mediated endothelial metabolic memory contributes to cardiac damage via small extracellular vesicles.
Reduced NRF2/Mfn2 activity promotes endoplasmic reticulum stress and senescence in adipose-derived mesenchymal stem cells in hypertrophic obese mice.
Targeting the SP/KLF Transcriptional Regulatory Network Synergizes with HDAC Inhibition to Impede Progression of H3K27M Diffuse Intrinsic Pontine Glioma.
Inhibition of NR2F2 Attenuates Vascular Dysfunction in Diabetic Retinopathy by Alleviating Endoplasmic Reticulum Stress in Retinal Microvascular Endothelial Cells.
ATP7A Maintains Bactericidal Function of Neutrophils and Macrophages via Regulating the Formation and Activation of Phagolysosomes.
KLF4 mediates the contradictory effects of phenylethyl isothiocyanate in gastric cancer intervention.
Targeting NAT10 attenuates homologous recombination via destabilizing DNA:RNA hybrids and overcomes PARP inhibitor resistance in cancers.
Changes in adrenoceptor expression level contribute to the cellular plasticity of glioblastoma cells.
Testis-Specific PDHA2 Is Required for Proper Meiotic Recombination and Chromosome Organisation During Spermatogenesis.
The Trim32-DPEP2 axis is an inflammatory switch in macrophages during intestinal inflammation.
Coriander-Derived Exosome-Like Nanovesicles Laden Hydrogel with Antioxidant Property Accelerates Wound Healing.
Identification of cytochrome P450 2E1 as a novel target in neuroinflammation and development of its inhibitor Q11 as a treatment strategy.
SARS-CoV-2 encoded ORF3a interacts with YY1 to promote latent HCMV reactivation.
Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration.
FTO-mediated m(6)A demethylation regulates IGFBP3 expression and AKT activation through IMP3-dependent P-body re-localisation in lung cancer.
Neuronal FGF13 Inhibits Mitochondria-Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease.
Role of PRC2 in the stochastic expression of Aire target genes and development of mimetic cells in the thymus.
Cardiac-specific overexpression of PRMT5 exacerbates pressure overload-induced hypertrophy and heart failure.
Cancer cell type-specific derepression of transposable elements by inhibition of chromatin modifier enzymes.
Targeted degradation of sICOSL reverses cytotoxic T cells dysfunction.
Nuclear Lactate Dehydrogenase A Resists Cardiomyocyte Cell Cycle Arrest Induced by Oxidative Stress.
Regulation of Mitochondrial Metabolism by Mfn1 Gene Encoding Mitofusin Affects Cellular Proliferation and Histone Modification.
Genome-wide CRISPR/Cas9 screening identifies PTGR2 as a potential therapeutic target for sunitinib resistance in clear cell renal cell carcinoma.
Altered cofactor recruitment and nucleosome dynamics underlie bisphenol A's impact on ERα-mediated transcriptional bursting.
KLF5-regulated ZDHHC8 reduces chemosensitivity in high-grade serous ovarian cancer through β-catenin signaling.
DHX9-mediated epigenetic silencing of BECN1 contributes to impaired autophagy and tumor progression in breast cancer via recruitment of HDAC5.
Bifidobacterium animalis subsp. Lactis BX-BC08 modulates gut microbiota and secretes alpha-Ketoglutaric acid to alleviate MC903-induced atopic dermatitis.
ACSS2 protects against alcohol-induced hepatocyte ferroptosis through regulation of hepcidin expression.
3-Oxo-11αH-germacra-1(10) E,4Z-dien-12,6α-olide, a sesquiterpene from Artemisia sieversiana, attenuates lipopolysaccharide-induced inflammation via NF-κB/MAPK pathways and oxidative stress via ROS pathway in RAW264.7 cells.
The steroid hormone 20-hydroxyecdysone inhibits RAPTOR expression by repressing Hox gene transcription to induce autophagy.
The translation initiation factor eIF2α regulates lipid homeostasis and metabolic aging.
Manganese is a potent inducer of lysosomal activity that inhibits de novo HBV infection.
PIEZO1 mediates matrix stiffness-induced tumor progression in kidney renal clear cell carcinoma by activating the Ca(2+)/Calpain/YAP pathway.
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway.
Impaired Iron-Sulfur Cluster Synthesis Induces Mitochondrial PARthanatos in Diabetic Cardiomyopathy.
Long non-coding RNA LINC01224 plays an oncogenic role in endometrial cancer via miR-4673/TPX2 axis and activating Wnt/β-catenin signaling pathway.
Inhibition of mTOR/S6K1/Gli1 signaling alleviates morphine-induced thermal hyperalgesia and tolerance.
Transplantation of engineered endothelial progenitor cells with H19 overexpression promotes arterial reendothelialization and inhibits neointimal hyperplasia.
SIX1 aggravates the progression of spinal cord injury in mice by promoting M1 polarization of microglia.
Modulation of Abnormal Vasoconstriction Through 2-Hydroxyisobutyrylation of Tropomyosin 3 Lys141: Targeting Histone Deacetylase 3 as a Key Approach.
The cholesterol metabolite 25-hydroxycholesterol suppresses porcine deltacoronavirus via lipophagy inhibition and mTORC1 modulation.
Cordycepin Extracted from Cordyceps militaris mitigated CUMS-induced depression of rats via targeting GSK3β/β-catenin signaling pathway.
Multi-platform analysis revealed the substance basis and mechanism of Wei-Tong-Xin in ameliorating ENS dysfunction for dyspepsia treatment.
Anionic polymer coating for enhanced delivery of Cas9 mRNA and sgRNA nanoplexes.
SPHK1 enhances olaparib resistance in ovarian cancer through the NFκB/NRF2/ferroptosis pathway.
ADSCs-derived exosomes suppress macrophage ferroptosis via the SIRT1/NRF2 signaling axis to alleviate acute lung injury in sepsis.
Apaf-1 is an evolutionarily conserved DNA sensor that switches the cell fate between apoptosis and inflammation.
MARTRE family proteins negatively regulate CCR4-NOT activity to protect poly(A) tail length and promote translation of maternal mRNA.
Loss of YTHDC1 m(6)A reading function promotes invasiveness in urothelial carcinoma of the bladder.
1,25(OH)(2)D(3) induces chondrocyte autophagy and reduces the loss of proteoglycans in osteoarthritis through inhibiting the NF-κB pathway.
Organophosphate flame retardant triphenyl phosphate (TPhP) induced colonic fibrosis by bringing about epithelial-mesenchymal transition.
Melittin suppresses ovarian cancer growth by regulating SREBP1-mediated lipid metabolism.
PNPO-Mediated Oxidation of DVL3 Promotes Multiple Myeloma Malignancy and Osteoclastogenesis by Activating the Wnt/β-Catenin Pathway.
Mono-ubiquitination of TopBP1 by PHRF1 enhances ATR activation and genomic stability.
Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3.
Targeted temperature management alleviates post-resuscitation myocardial dysfunction by inhibiting ferroptosis.
Targeting p38 MAPK signaling pathway and neutrophil extracellular traps: An important anti-inflammatory mechanism of Huangqin Qingre Chubi Capsule in rheumatoid arthritis.
NINJ1-mediated plasma membrane rupture of pyroptotic endothelial cells exacerbates blood-brain barrier destruction caused by neutrophil extracellular traps in traumatic brain injury.
A glucose-enriched lung pre-metastatic niche triggered by matrix stiffness-tuned exosomal miRNAs in hepatocellular carcinoma.
PBX1 attenuates inflammation and apoptosis of trophoblast cells induced by LPS through downregulating the transcription of TMUB1: PBX1 ameliorates RSA development.
GLS1-mediated glutamine metabolism mitigates oxidative stress-induced matrix degradation, ferroptosis, and senescence in nucleus pulposus cells by modulating Fe(2+) homeostasis.
Role of the NuRD complex and altered proteostasis in cancer cell quiescence.
Mettl3/Eed/Ythdc1 regulatory axis controls endometrial receptivity and function.
SIRT6 inhibits endoplasmic reticulum stress-mediated ferroptosis by activating Nrf2/HO-1 signaling to alleviate osteoarthritis.
WWP2 Overexpression Represses NLRP3 Inflammasome Activation in Cerebral Ischemia/Reperfusion Injury Through the Degradation of MAVS.
AKR1B1 is Required for Maintaining Acute Leukemia Cell Survival by Epigenetic Silencing of Tumor Suppressor Genes.
Higenamine Hydrochloride Attenuates Neuroinflammation in Type I Diabetic Mice by Inhibiting the CRTC2-CREB Signaling Pathway via PAK4.
Pharmacological Activation of GPR68 Attenuates Ferroptosis in Spinal Cord Ischemia/Reperfusion Injury Through PI3K/Akt-Mediated Nrf2 Antioxidant Pathway.
RAB3A-mediated BAG6 translocation promotes non-small cell lung cancer tumorigenesis and progression.
Tanshinone IIA alleviates LPS-induced acute kidney injury by inhibiting RIP3/Nrf2-mediated oxidative stress.
Hypoxia-induced MT2A-tetrameric PKM2 interaction maintains PKM2 activity in a copper-ion-dependent manner.
CircRAB23 functions as miR-532-3p sponge to promote the malignant proliferation and metastasis of intrahepatic cholangiocarcinoma through HMGA2-EMT axis.
Apelin-13 Attenuates Blood-Brain Barrier Dysfunction Following Intracerebral Hemorrhage via Targeting the Keap1/Nrf2 Signaling.
TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD.
WDR4 drives tumour-associated macrophage reprogramming and tumour progression via selective translation and membrane cholesterol efflux.
Pseudorabies virus gM protein and herpesvirus homologs block selective autophagy to enhance viral replication.
COL4A2 drives ECM remodeling and stiffness increasing to promote breast cancer metastasis via YAP signaling pathway in dECM induced models.
Naringenin boosts Parkin-mediated mitophagy via estrogen receptor alpha to maintain mitochondrial quality control and heal diabetic foot ulcer.
A novel HDAC1-specific inhibitor prevents estrogen deficiency-induced osteoporosis in mice by inhibiting osteoclast function.
YAP regulates the hypertrophy and apoptosis of antler chondrocytes through maintaining calcium homeostasis and mitochondrial function.
Aloe-Emodin Targeting FOXC2 Disrupts NETs Formation and EMT-Driven Postoperative Peritoneal Adhesion Through TGF-β1-Smad2/3 Pathway.
Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR-NFκB Pathway.
KDM6B induces demethylation of H3K27me3 in MFN1 to modulate aberrant mitophagy in sepsis-induced acute lung injury.
Cyclin B2 facilitates glycolysis and tumor progression in pancreatic ductal adenocarcinoma by promoting histone lactylation.
OPRK1 drives SLC9A3R1 progression to neuroendocrine prostate cancer.
Genetic depletion or pharmacological degradation of EZH2 attenuates renal fibrosis via suppressing Notch signaling.
Lactylation-driven KRT19 promotes non-small cell lung cancer progression by suppressing cellular senescence.
SARS-CoV-2 nsp14 induces the m(7)G methylation and the sequestration of host RNAs in stress granules.
SREBP1-mediated lipogenesis promotes dedifferentiation and senescence of vascular smooth muscle cells through epigenetic remodeling.
SIRT7 Promotes Hepatitis B Virus Transcription via the Upregulation of DDB1 Expression and Facilitation of DDB1 Recruitment to Covalently Closed Circular DNA.
IGF2BP3-STAT3-METTL3 axis promotes malignant progression in hepatocellular carcinoma (HCC).
DNA repair pathway-related proteins are involved in the circularization step of microDNA eccDNA(fib-L).
CCL8 suppresses ovarian cancer progression via M1 macrophage polarization and NF-κB-mediated apoptosis.
Nucleosome assembly protein-like 1 degradation-dependent novel cardioprotection mechanism of Wnt2 against ischemia‒reperfusion injury.
Conformational Dynamics of PKM2 Regulate Hypoxia-Induced Pathological Retinal Angiogenesis.
Cuspidatyl Ferulate, a Novel Phenolic Acid from Hyssopus cuspidatus Borris, Protects Hepatocytes Against Oxidative Damage via Keap1 Interaction.
Integrated stress response activation induced by usnic acid alleviates BCL-2 inhibitor ABT-199 resistance in acute myeloid leukemia.
tsRNA-08614 inhibits glycolysis and histone lactylation by ALDH1A3 to confer oxaliplatin sensitivity in colorectal cancer.
The lncRNA ST18-AS1 suppresses pancreatic cancer progression by enhancing ST18 mRNA stability through anchoring FUS in the cytoplasm.
SETD5 facilitates stemness and represses ferroptosis via m6A-mediating PKM2 stabilization in non-small cell lung cancer.
The transcription factor Y-box binding protein 3 contributes to mechanical allodynia and anxiety-like behavior in trigeminal neuralgia by transcriptionally triggering period circadian regulator 1 in primary sensory neurons.
MAP3K15 facilitates multiple viral genes expression in crustaceans via Dorsal-CC-CL-STAT axis besides the JNK/P38 pathway.
Mitochondrial Protease AFG3L2 Inhibits Ferroptosis of Intestinal Epithelial Cells through PPARA/GPX4 Signaling Pathway to Improve Experimental Enteritis.
USP5-Rich Apoptotic Extracellular Vesicles Regulate Nucleus Pulposus Cells Apoptosis and DNA Damage Repair by Preventing E2F1 Proteasomal Degradation.
Pretreatment with dimethyl fumarate prevents chronic pain and its comorbidities via Nrf2 pathway in a rat model of neuropathic pain.
Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8-AS1/GPX4 Axis in Intrahepatic Cholangiocarcinoma.
ACSS2-Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7.
SETD2 drives METTL14-mediated m(6)A to suppress Piezo1 Attenuation and activate TGM2 to promote pulmonary hypertension.
Integrative Proteomics and Histone PTMomics Study on Anti-TNBC Effect of JIB-04.
Arachidonic acid triggers spermidine synthase secretion from primary tumor to induce skeletal muscle weakness upon irradiation.
SERBP1-PCIF1 complex-controlled m6Am modification in glutamatergic neurons of the primary somatosensory cortex is required for neuropathic pain in mice.
Histone H3K27 acetylation mediated by KAT8 maintains antiviral trained immunity in shrimp induced by inactivated white spot syndrome virus.
Xiaoyaosan alleviates chronic psychological stress-induced TH17/Treg imbalance via modulation of the FKBP5/NF-κB axis.
Insect dome receptor directly recognizes viral envelopes to activate JAK/STAT signaling and induce conserved antiviral viperin expression.
Extrachromosomal DNA biogenesis is dependent on DNA looping and religation by YY1-Lig3-PARylation complex.
A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma.
LENG8 mediates RNA nuclear retention and degradation in eukaryotes.
MRO/HNRNPU/CCL5 feedback loop amplifies M2 macrophage and breast cancer cell crosstalk to drive progression.
MSC-derived exosomes alleviate oxidative stress-induced lysosomal membrane permeabilization damage in degenerated nucleus pulposus cells via promoting m6A demethylation of Nrf2.
CIP2A promotes bronchiolitis obliterans by activating the NF‑κB pathway.
Hydrogen sulfide sustains mitochondria functions via targeting mitochondria fission regulator 1 like protein to restore human cytotrophoblast invasion and migration.
TGR5 attenuates DOCA-salt hypertension through regulating histone H3K4 methylation of ENaC in the kidney.
SAE1 promotes tumor cell malignancy via SUMOylation and liquid-liquid phase separation facilitated nuclear export of p27.
GRK2 activates TRAF2-NF-κB signalling to promote hyperproliferation of fibroblast-like synoviocytes in rheumatoid arthritis.
Lipid Droplets Metabolism Mediated by ANXA7-PPARγ Signaling Axis Regulates Spinal Cord Injury Repair in Mice.
Positive Feedback Regulation between KLF5 and XPO1 Promotes Cell Cycle Progression of Basal like Breast Cancer.
CK2B Induces CD8(+) T-Cell Exhaustion through HDAC8-Mediated Epigenetic Reprogramming to Limit the Efficacy of Anti-PD-1 Therapy in Non-Small-Cell Lung Cancer.
The highly expressed GOLPH3 in colorectal cancer cells activates smoothened to drive glycolysis and promote cancer cell growth and radiotherapy resistance.
Oxidized low-density lipoprotein induced ferroptosis in nucleus pulposus cell contributes to intervertebral disc degeneration via LOX-1/NF-κB/NOX signal.
Neutrophil extracellular traps induced by neoadjuvant chemotherapy of breast cancer promotes vascular endothelial damage.
Nicotinamide mononucleotide promotes female germline stem cell proliferation by activating the H4K16ac-Hmgb1-Fyn-PLD signaling pathway through epigenetic remodeling.
The dual HDAC/PI3K inhibitor CUDC-907 inhibits the growth and proliferation of MYC-driven Group 3 medulloblastoma.
Epigenetic modulation of RIPK3 by transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis.
miR-32-5p suppresses the progression of hepatocellular carcinoma by regulating the GSK3β/NF-κB signaling.
AP001885.4 promotes the proliferation of esophageal squamous cell carcinoma cells by histone lactylation- and NF-κB (p65)-dependent transcription activation and METTL3-mediated mRNA stability of c-myc.
Catalpol alleviates amyloid- generation and neuronal oxidative stress injury via activating the Keap1-Nrf2/ARE signaling pathway in the immortalized lymphocytes from patients with late-onset Alzheimer's disease and SKNMC cells co-culture model.
Dietary Fiber-Derived Microbial Butyrate Suppresses ILC2-Dependent Airway Inflammation in COPD.
The m6A modification-mediated positive feedback between glycolytic lncRNA SLC2A1-DT and c-Myc promotes tumorigenesis of hepatocellular carcinoma.
KMT2D mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-induced regulatory T cell trafficking via FBXW7-NOTCH-MYC/TGF-β1 axis.
RASSF4 Attenuates Metabolic Dysfunction-Associated Steatotic Liver Disease Progression via Hippo Signaling and Suppresses Hepatocarcinogenesis.
MicroRNA-204-5p Ameliorates Renal Injury via Regulating Keap1/Nrf2 Pathway in Diabetic Kidney Disease.
Puerarin ameliorates non-alcoholic fatty liver disease by inhibiting lipid metabolism through FMO5.
Staphylococcus aureus wraps around Candida albicans and synergistically escapes from Neutrophil extracellular traps.
Placental mesenchymal stem cells suppress inflammation and promote M2-like macrophage polarization through the IL-10/STAT3/NLRP3 axis in acute lung injury.
Extracellular putrescine can augment the epithelial-mesenchymal transition of gastric cancer cells by promoting MAL2 expression by elevating H3K27ac in its promoter region.
Methyl-CpG-binding 2 K271 lactylation-mediated M2 macrophage polarization inhibits atherosclerosis.
Full-length GSDME mediates pyroptosis independent from cleavage.
Moxibustion ameliorates ovarian function in premature ovarian insufficiency rats by activating cAMP/PKA/CREB to promote steroidogenesis in ovarian granulosa cells.
Puerarin suppresses macrophage M1 polarization to alleviate renal inflammatory injury through antagonizing TLR4/MyD88-mediated NF-κB p65 and JNK/FoxO1 activation.
NSD2-mediated H3K36me2 exacerbates osteoporosis via activation of hoxa2 in bone marrow mesenchymal stem cells.
Uremic Toxin Receptor AhR Facilitates Renal Senescence and Fibrosis via Suppressing Mitochondrial Biogenesis.
Design, Synthesis, and Biological Evaluation of HDAC Inhibitors Containing Natural Product-Inspired N-Linked 2-Acetylpyrrole Cap.
Indoxyl sulfate induces retinal microvascular injury via COX-2/PGE(2) activation in diabetic retinopathy.
Qin-Yu-Qing-Chang decoction reshapes colonic metabolism by activating PPAR-γ signaling to inhibit facultative anaerobes against DSS-induced colitis.
Transient splicing inhibition causes persistent DNA damage and chemotherapy vulnerability in triple-negative breast cancer.
PICKLE-mediated nucleosome condensing drives H3K27me3 spreading for the inheritance of Polycomb memory during differentiation.
Forkhead box protein FOXK1 disrupts the circadian rhythm to promote breast tumorigenesis in response to insulin resistance.
Exogenous thyroxine increases cardiac GLUT4 translocation in insulin resistant OLETF rats.
Loss of Malignancy of Super-Methotrexate-resistant Osteosarcoma Cells Is Associated With an Increase of Methylated Histone Marks H3K9me3 and H3K27me3.
ATR/Chk1 interacting lncRNA modulates DNA damage response to induce breast cancer chemoresistance.
UBE2S facilitates glioblastoma progression through activation of the NF-κB pathway via attenuating K11-linked ubiquitination of AKIP1.
Corilagin alleviates ferroptosis in diabetic retinopathy by activating the Nrf2 signaling pathway.
S100A2 activation promotes interstitial fibrosis in kidneys by FoxO1-mediated epithelial-mesenchymal transition.
Characterizations of Protein Arginine Deiminase 1 as a Substrate of NTMT1: Implications of Nα-Methylation in Protein Stability and Interaction.
Protective effect of 8-Gingerol, a potent constituent of ginger, on acute lung injury following hemorrhagic shock in rats.
Cecal necroptosis triggers lethal cardiac dysfunction in TNF-induced severe SIRS.
Reduced expression of NUPR1 alleviates epilepsy progression via attenuating ER stress.
KLF4 regulates trophoblast function and associates with unexplained recurrent spontaneous abortion.
Acetate utilization promotes hormone therapy resistance in prostate cancer through neuroendocrine differentiation.
Geniposidic Acid Attenuates Chronic Tubulointerstitial Nephropathy Through Regulation of the NF-ƙB/Nrf2 Pathway Via Aryl Hydrocarbon Receptor Signaling.
The PRMT6/STAT1/ACSL1 axis promotes ferroptosis in diabetic nephropathy.
The highly conserved region within exonuclease III-like in PML-I regulates the cytoplasmic localization of PML-NBs.
Sirt6 Mono-ADP-Ribosylates YY1 to Promote Dystrophin Expression for Neuromuscular Transmission.
Lung-Targeted Lipid Nanoparticle-Delivered siUSP33 Attenuates SARS-CoV-2 Replication and Virulence by Promoting Envelope Degradation.
Unveiling Smyd-2's Role in Cytoplasmic Nrf-2 Sequestration and Ferroptosis Induction in Hippocampal Neurons After Cerebral Ischemia/Reperfusion.
Mitochondrial miRNAs and fibromyalgia: new biomarker candidates.
Biliverdin improved angiogenesis and suppressed apoptosis via PI3K/Akt-mediated Nrf2 antioxidant system to promote ischemic flap survival.
Impaired mitochondrial oxidative phosphorylation induces CD8(+) T cell exhaustion.
Effects on Synaptic Plasticity Markers in Fetal Mice and HT22 Neurons upon F-53B Exposure: The Role of PKA Cytoplasmic Retention.
Alarmin-loaded extracellular lipid droplets induce airway neutrophil infiltration during type 2 inflammation.
TIRR regulates mRNA export and association with P-bodies in response to DNA damage.
HACE1 exerts a neuroprotective role against oxidative stress in cerebral ischemia-reperfusion injury by activating the PI3K/AKT/Nrf2 pathway.
TIPE2 aggravates experimental colitis and disrupts intestinal epithelial barrier integrity by activating JAK2/STAT3/SOCS3 signal pathway.
Syk-dependent homologous recombination activation promotes cancer resistance to DNA targeted therapy.
Synaptic vesicle protein 2A mitigates parthanatos via apoptosis-inducing factor in a rat model of pharmacoresistant epilepsy.
m(6)A-induced TRIB3 regulates Hippo pathway through interacting with LATS1 to promote the progression of lung adenocarcinoma.
Apoptosis-inducing factor 1 mediates Vibrio splendidus-induced coelomocyte apoptosis via importin β dependent nuclear translocation in Apostichopus japonicus.
Pirfenidone alleviates fibrosis by acting on tumour-stroma interplay in pancreatic cancer.
NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors.
Cynarin alleviates acetaminophen-induced acute liver injury through the activation of Keap1/Nrf2-mediated lipid peroxidation defense via the AMPK/SIRT3 signaling pathway.
D-mannose alleviates intervertebral disc degeneration through glutamine metabolism.
Microglial Pdcd4 deficiency mitigates neuroinflammation-associated depression via facilitating Daxx mediated PPARγ/IL-10 signaling.
Medical ozone alleviates acute lung injury by enhancing phagocytosis targeting NETs via AMPK/SR-A1 axis.
PRMT1 promotes epigenetic reprogramming associated with acquired chemoresistance in pancreatic cancer.
Excessive proliferating cell nuclear antigen attenuates endometrial adhesive capacity and decidualization in patients with recurrent implantation failure.
Mycobacterial CpsA activates type I IFN signaling in macrophages via cGAS-mediated pathway.
Synergistic effect of mesenchymal stem cell-derived extracellular vesicle and miR-137 alleviates autism-like behaviors by modulating the NF-κB pathway.
Deubiquitinase USP4 suppresses antitumor immunity by inhibiting IRF3 activation and tumor cell-intrinsic interferon response in colorectal cancer.
Single-cell transcriptome analysis reveals the association between histone lactylation and cisplatin resistance in bladder cancer.
KAT8 is upregulated and recruited to the promoter of Atg8 by FOXO to induce H4 acetylation for autophagy under 20-hydroxyecdysone regulation.
Glucose-derived glutamate drives neuronal terminal differentiation in vitro.
Chemical Proteomics Reveals N(ε)-Fatty-Acylation of Septins by Rho Inactivation Domain (RID) of the Vibrio MARTX Toxin to Alter Septin Localization and Organization.
EHMT2 promotes tumorigenesis in GNAQ/11-mutant uveal melanoma via ARHGAP29-mediated RhoA pathway.
Chicken speckle-type POZ protein (SPOP) negatively regulates MyD88/NF-κB signaling pathway mediated proinflammatory cytokine production to promote the replication of Newcastle disease virus.
Antagonizing roles of SHP1 in the pathogenesis of Helicobacter pylori infection.
Histone lactylation promotes malignant progression by facilitating USP39 expression to target PI3K/AKT/HIF-1α signal pathway in endometrial carcinoma.
Macrophage-derived exosomal HMGB3 regulates silica-induced pulmonary inflammation by promoting M1 macrophage polarization and recruitment.
CDKL1 potentiates the antitumor efficacy of radioimmunotherapy by binding to transcription factor YBX1 and blocking PD-L1 expression in lung cancer.
Interaction between the SFTSV envelope glycoprotein Gn and STING inhibits the formation of the STING-TBK1 complex and suppresses the NF-κB signaling pathway.
L-Theanine alleviates heat stress through modulation of gut microbiota and immunity.
MRE11A: a novel negative regulator of human DNA mismatch repair.
Alistipes indistinctus-derived hippuric acid promotes intestinal urate excretion to alleviate hyperuricemia.
Ammonia stress-induced heat shock factor 1 enhances white spot syndrome virus infection by targeting the interferon-like system in shrimp.
Echinacoside alleviates glucocorticoid induce osteonecrosis of femoral head in rats through PI3K/AKT/FOXO1 pathway.
Ponicidin-induced conformational changes of HSP90 regulates the MAPK pathway to relieve ulcerative colitis.
Lysine specific demethylase 1 inhibits sodium arsenite activation of HSCs by regulating SESN2/AMPK/ULK1 signaling pathway activity.
Celastrol enhances the viability of random-pattern skin flaps by regulating autophagy through the AMPK-mTOR-TFEB axis.
The antidepressant effects of protein arginine methyltransferase 2 involve neuroinflammation.
Dihydromyricetin regulates KEAP1-Nrf2 pathways to enhance the survival of ischemic flap.
Experimental verification about treatment of Bu-Shen-Yi-Jing-Fang in Alzheimer's disease by the analysis of the feasible signaling pathway of network pharmacology.
Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal Transition.
PPIA dictates NRF2 stability to promote lung cancer progression.
YZL-51N functions as a selective inhibitor of SIRT7 by NAD(+) competition to impede DNA damage repair.
TERC promotes non-small cell lung cancer progression by facilitating the nuclear localization of TERT.
Low PDE4A expression promoted the progression of ovarian cancer by inducing Snail nuclear translocation.
Sodium arsenite induces hepatic stellate cells activation by m(6)A modification of TGF-β1 during liver fibrosis.
Cell surface CD55 traffics to the nucleus leading to cisplatin resistance and stemness by inducing PRC2 and H3K27 trimethylation on chromatin in ovarian cancer.
GITR exacerbates lysophosphatidylcholine-induced macrophage pyroptosis in sepsis via posttranslational regulation of NLRP3.
Platelet-Derived TGF-β1 Promotes Deep Vein Thrombosis.
CircUGGT2 facilitates progression and cisplatin resistance of bladder cancer through nonhomologous end-joining pathway.
Absence of PD-L1 signaling hinders macrophage defense against Mycobacterium tuberculosis via upregulating STAT3/IL-6 pathway.
Nuclear translocation of ISG15 regulated by PPP2R2B inhibits cisplatin resistance of bladder cancer.
PRMT5-mediated arginine methylation of FXR1 is essential for RNA binding in cancer cells.
Human cytomegalovirus infection impairs neural differentiation via repressing sterol regulatory element binding protein 2-mediated cholesterol biosynthesis.
Puerarin enhances TFEB-mediated autophagy and attenuates ROS-induced pyroptosis after ischemic injury of random-pattern skin flaps.
A role for YAP/FOXM1/Nrf2 axis in oxidative stress and apoptosis of cataract induced by UVB irradiation.
Esaxerenone Attenuates Aldosterone-Induced Mitochondrial Damage-Mediated Pyroptosis in Mouse Aorta and Rat Vascular Smooth Muscle Cells.
Screening and identification of miRNAs negatively regulating FAM83A/Wnt/β-catenin signaling pathway in non-small cell lung cancer.
Podophyllotoxin via SIRT1/PPAR /NF-κB axis induced cardiac injury in rats based on the toxicological evidence chain (TEC) concept.
METTL1-modulated LSM14A facilitates proliferation and migration in glioblastoma via the stabilization of DDX5.
TAPI-1 Exhibits Anti-tumor Efficacy in Human Esophageal Squamous Cell Carcinoma Cells via Suppression of NF-κB Signaling Pathway.
Honokiol Attenuates Choroidal Neovascularization by Inhibiting the Hypoxia-Inducible Factor-α/Vascular Endothelial Growth Factor Axis via Nuclear Transcription Factor-Kappa B Activation.
New mode of action of curcumin on prostate cancer cells: Modulation of endoplasmic reticulum-associated degradation mechanism and estrogenic signaling.
CircDYM attenuates microglial apoptosis via CEBPB/ZC3H4 axis in LPS-induced mouse model of depression.
Lactobacillus species ameliorate membranous nephropathy through inhibiting the aryl hydrocarbon receptor pathway via tryptophan-produced indole metabolites.
SH3RF2 contributes to cisplatin resistance in ovarian cancer cells by promoting RBPMS degradation.
CLIC3 interacts with NAT10 to inhibit N4-acetylcytidine modification of p21 mRNA and promote bladder cancer progression.
Knockdown of Smox protects the integrity of the blood-brain barrier through antioxidant effect and Nrf2 pathway activation in stroke.
BCL7A and BCL7B potentiate SWI/SNF-complex-mediated chromatin accessibility to regulate gene expression and vegetative phase transition in plants.
Monotropein induces autophagy through activation of the NRF2/PINK axis, thereby alleviating sepsis-induced colonic injury.
Mesencephalic astrocyte-derived neurotrophic factor (MANF) alleviates cerebral ischemia/reperfusion injury in mice by regulating microglia polarization via A20/NF-κB pathway.
LRP11 promotes stem-like T cells via MAPK13-mediated TCF1 phosphorylation, enhancing anti-PD1 immunotherapy.
MiR-31-5p regulates the neuroinflammatory response via TRAF6 in neuropathic pain.
YAP represses intestinal inflammation through epigenetic silencing of JMJD3.
The SOX4/EZH2/SLC7A11 signaling axis mediates ferroptosis in calcium oxalate crystal deposition-induced kidney injury.
Metabolic regulation of homologous recombination repair by MRE11 lactylation.
The P286R mutation of DNA polymerase ε activates cancer-cell-intrinsic immunity and suppresses endometrial tumorigenesis via the cGAS-STING pathway.
Ochratoxin A-enhanced glycolysis induces inflammatory responses in human gastric epithelium cells through mTOR/HIF-1α signaling pathway.
Celastrol-loaded bovine serum albumin nanoparticles target inflamed neutrophils for improved rheumatoid arthritis therapy.
Amyloid aggregates induced by the p53-R280T mutation lead to loss of p53 function in nasopharyngeal carcinoma.
ALA-PDT promotes the death and contractile capacity of hypertrophic scar fibroblasts through inhibiting the TGF-β1/Smad2/3/4 signaling pathway.
Targeting CD38/ ADP-ribosyl cyclase as a novel therapeutic strategy for identification of three potent agonists for leukopenia treatment.
Inhibition of SIRT7 promotes STAT1 activation and STAT1-dependent signaling in hepatocellular carcinoma.
The Interplay Between HIF-1α and EZH2 in Lung Cancer and Dual-Targeted Drug Therapy.
Epigenetic drug screening for trophoblast syncytialization reveals a novel role for MLL1 in regulating fetoplacental growth.
Altered nuclear envelope homeostasis is a key pathogenic event in C9ORF72-linked ALS/FTD.
Rosavin Alleviates LPS-Induced Acute Lung Injure by Modulating the TLR-4/NF-κB/MAPK Singnaling Pathways.
YTHDF2-mediated circYAP1 drives immune escape and cancer progression through activating YAP1/TCF4-PD-L1 axis.
Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers.
Eriocalyxin B alleviated ischemic cerebral injury by limiting microglia-mediated excessive neuroinflammation in mice.
MAPRE3 as an epigenetic target of EZH2 restricts ovarian cancer proliferation in vitro and in vivo.
Salivary-secreted vitellogenin suppresses H(2)O(2) burst of plants facilitating Recilia dorsalis leafhopper feeding.
Insulin-Like Growth Factor-Binding Protein 5 Promotes the Cell Proliferation and Osteogenic Potential of Dental Pulp Stem Cells Dependent on Its Nuclear Localisation Sequence.
Targeting CA9 restricts pancreatic cancer progression through pH regulation and ROS production.
SETD2 deficiency in peripheral sensory neurons induces allodynia by promoting NMDA receptor expression through NFAT5 in rodent models.
New TIPARP inhibitor rescues mitochondrial function and brain injury in ischemic stroke.
TRPV4-β-catenin axis is a novel therapeutic target for dry skin-induced chronic itch.
Design, synthesis, and biological evaluation of novel AAK1/HDACs dual inhibitors against SARS-CoV-2 entry.
Key role of PPAR-γ-mediated suppression of the NFκB signaling pathway in rutin's antidepressant effect.
4-Hydroxydictyolactone alleviates cerebral ischemia injury by regulating neuroinflammation and autophagy via AMPK signaling pathway.
Obacunone improves dihydrotestosterone-induced androgen alopecia by inhibiting androgen receptor dimerization.
Adropin regulates macrophage phenotype via PPARγ signalling: A preliminary study of adropin and Crohn's disease.
The miR-6240 target gene Igf2bp3 promotes myoblast fusion by enhancing myomaker mRNA stability.
Monotropein alleviates septic acute liver injury by restricting oxidative stress, inflammation, and apoptosis via the AKT (Ser473)/GSK3β (Ser9)/Fyn/NRF2 pathway.
Palmatine attenuates MYH9 mediated nuclear localization of AURKA to induce G2/M phase arrest in colorectal cancer cells.
Neuregulin-1 reduces Doxorubicin-induced cardiotoxicity by upregulating YAP to inhibit senescence.
Mutation on JmjC domain of UTX impaired its antitumor effects in pancreatic cancer via inhibiting G0S2 expression and activating the Toll-like signaling pathway.
Targeting TRAF6/IRF3 axis to inhibit NF-κB-p65 nuclear translocation enhances the chemosensitivity of 5-FU and reverses the proliferation of gastric cancer.
Lactate Dehydrogenase Inhibition Protects against Hepatic Fibrosis by Regulating Metabolic Reprogramming of Hepatic Stellate Cells.
myCAF-derived exosomal PWAR6 accelerates CRC liver metastasis via altering glutamine availability and NK cell function in the tumor microenvironment.
RRM1 promotes homologous recombination and radio/chemo-sensitivity via enhancing USP11 and E2F1-mediated RAD51AP1 transcription.
Soyasaponin Bb/Gelatin-Methacryloyl Hydrogel for Cartilage Inflammation Inhibition.
Pharmacodynamic insights into maresin 1: Enhancing flap viability via the keap1/Nrf2 axis to control ROS-driven apoptosis and ferroptosis.
Downregulation of chemoresistance by claudin-14 silencing in human colorectal cancer cells.
Sweroside alleviates pressure overload-induced heart failure through targeting CaMKⅡδ to inhibit ROS-mediated NF-κB/NLRP3 in cardiomyocytes.
Curcumin inhibits PAT-induced renal ferroptosis via the p62/Keap1/Nrf2 signalling pathway.
CRHR1 antagonist alleviated depression-like behavior by downregulating p62 in a rat model of post-stroke depression.
Nrf2 activation by pyrroloquinoline quinone inhibits natural aging-related intervertebral disk degeneration in mice.
Ubiquitin-specific peptidase 15 regulates the TFAP4/PCGF1 axis facilitating liver metastasis of colorectal cancer and cell stemness.
Extracellular vesicles miR-31-5p promotes pancreatic cancer chemoresistance via regulating LATS2-Hippo pathway and promoting SPARC secretion from pancreatic stellate cells.
The Compromised Fanconi Anemia Pathway in Prelamin A-Expressing Cells Contributes to Replication Stress-Induced Genomic Instability.
Insect ribosome-rescuer Pelo-Hbs1 complex on sperm surface mediates paternal arbovirus transmission.
Discovery of Potent and Selective G9a Degraders for the Treatment of Pancreatic Cancer.
The extracellular matrix integrates mitochondrial homeostasis.
The WDR11 complex is a receptor for acidic-cluster-containing cargo proteins.
Mechanism of ASF1 Inhibition by CDAN1.
Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer.
PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson's disease.
KAT7 serves as an oncogenic gene and regulates CCL3 expression via STAT1 signaling in osteosarcoma.
Cryptotanshinone alleviates liver fibrosis via inhibiting STAT3/CPT1A-dependent fatty acid oxidation in hepatic stellate cells.
Discovery of Novel Imidazo[1,2-a]pyridine-Based HDAC6 Inhibitors as an Anticarcinogen with a Cardioprotective Effect.
Two-polarized roles of transcription factor FOSB in lung cancer progression and prognosis: dependent on p53 status.
The cellular Notch1 protein promotes KSHV reactivation in an Rta-dependent manner.
Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damage.
CDK4/6 Alters TBK1 Phosphorylation to Inhibit the STING Signaling Pathway in Prostate Cancer.
Regulation of Hippo/YAP axis in colon cancer progression by the deubiquitinase JOSD1.
Revealing the mechanism of ethyl acetate extracts of Semen Impatientis against prostate cancer based on network pharmacology and transcriptomics.
Hypoxia conduces the glioma progression by inducing M2 macrophage polarization via elevating TNFSF9 level in a histone-lactylation-dependent manner.
CUDC-907 exhibits potent antitumor effects against ovarian cancer through multiple in vivo and in vitro mechanisms.
A novel 2-iminobenzimidazole compound, XYA1353, displays in vitro and in vivo anti-myeloma activity via targeting NF-κB signaling.
STING deficiency alleviates ferroptosis through FPN1 stabilization in diabetic kidney disease.
A snake cathelicidin enhances transcription factor EB-mediated autophagy and alleviates ROS-induced pyroptosis after ischaemia-reperfusion injury of island skin flaps.
Genetically encoded bioorthogonal tryptophan decaging in living cells.
Mitochondrial dysfunction induced by HIF-1α under hypoxia contributes to the development of gastric mucosal lesions.
The BAS chromatin remodeler determines brassinosteroid-induced transcriptional activation and plant growth in Arabidopsis.
Rewiring of a KNOXI regulatory network mediated by UFO underlies the compound leaf development in Medicago truncatula.
Neuroprotective effects of takinib on an experimental traumatic brain injury rat model via inhibition of transforming growth factor beta-activated kinase 1.
Diphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects.
Ginsenoside Rg1 attenuates lipopolysaccharide-induced chronic liver damage by activating Nrf2 signaling and inhibiting inflammasomes in hepatic cells.
hnRNPU is required for spermatogonial stem cell pool establishment in mice.
Depletion of Mettl3 in cholinergic neurons causes adult-onset neuromuscular degeneration.
Interaction with B-type lamin reveals the function of Drosophila Keap1 xenobiotic response factor in nuclear architecture.
Urolithin B reduces cartilage degeneration and alleviates osteoarthritis by inhibiting inflammation.
Inhibition of autophagy-related protein 7 enhances anti-tumor immune response and improves efficacy of immune checkpoint blockade in microsatellite instability colorectal cancer.
Fosl2 Deficiency Predisposes Mice to Osteopetrosis, Leading to Bone Marrow Failure.
Baicalin Ameliorates Lung Injury in Rats by Inhibiting NLRP3 Inflammasome Activation via NF-[Formula: see text]B Signaling Pathway.
Maslinic Acid Ameliorates Myocardial Ischemia Reperfusion Injury-Induced Oxidative Stress via Activating Nrf2 and Inhibiting NF-[Formula: see text]B Pathways.
Identification of the H3K36me3 reader LEDGF/p75 in the pancancer landscape and functional exploration in clear cell renal cell carcinoma.
ESRG is critical to maintain the cell survival and self-renewal/pluripotency of hPSCs by collaborating with MCM2 to suppress p53 pathway.
Low expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis.
FGF2 Alleviates Microvascular Ischemia-Reperfusion Injury by KLF2-mediated Ferroptosis Inhibition and Antioxidant Responses.
Glycolysis mediates neuron specific histone acetylation in valproic acid-induced human excitatory neuron differentiation.
Inhibition of Non-small Cell Lung Cancer by Ferroptosis and Apoptosis Induction through P53 and GSK-3β/Nrf2 Signal Pathways using Qingrehuoxue Formula.
IL-37 counteracts inflammatory injury in the temporomandibular joint via the intracellular pathway.
ALDH2 attenuates myocardial pyroptosis through breaking down Mitochondrion-NLRP3 inflammasome pathway in septic shock.
Histone H3K27 methyltransferase EZH2 regulates apoptotic and inflammatory responses in sepsis-induced AKI.
Development of triazole-based PKC-inhibitors to overcome resistance to EGFR inhibitors in EGFR-mutant lung cancers.
DOT1L promotes cell proliferation and invasion by epigenetically regulating STAT5B in renal cell carcinoma.
Lysine methylation of PPP1CA by the methyltransferase SUV39H2 disrupts TFEB-dependent autophagy and promotes intervertebral disc degeneration.
Ghrelin promotes cardiomyocyte differentiation of adipose tissue‑derived mesenchymal stem cells by DDX17‑mediated regulation of the SFRP4/Wnt/β‑catenin axis.
Pan-cancer integrated bioinformatic analysis of RNA polymerase subunits reveal RNA Pol I member CD3EAP regulates cell growth by modulating autophagy.
Estrogens drive the endoplasmic reticulum-associated degradation and promote proto-oncogene c-Myc expression in prostate cancer cells by androgen receptor/estrogen receptor signaling.
Degradation of histone deacetylase 6 alleviates ROS-mediated apoptosis in renal ischemia-reperfusion injury.
METTL3-mediated N6-methyladenosine exacerbates ferroptosis via m6A-IGF2BP2-dependent mitochondrial metabolic reprogramming in sepsis-induced acute lung injury.
Triiodothyronine positively regulates endoplasmic reticulum-associated degradation (ERAD) and promotes androgenic signaling in androgen-dependent prostate cancer cells.
CD8 T Cell-Derived Exosomal miR-186-5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis.
GART Functions as a Novel Methyltransferase in the RUVBL1/β-Catenin Signaling Pathway to Promote Tumor Stemness in Colorectal Cancer.
ECSIT Is a Critical Factor for Controlling Intestinal Homeostasis and Tumorigenesis through Regulating the Translation of YAP Protein.
FBL promotes cancer cell resistance to DNA damage and BRCA1 transcription via YBX1.
LINC00460 promotes angiogenesis by enhancing NF-κB-mediated VEGFA expression in cervical cancer cells.
Antidiabetic Effect of Collagen Peptides from Harpadon nehereus Bones in Streptozotocin-Induced Diabetes Mice by Regulating Oxidative Stress and Glucose Metabolism.
Krüppel-like Factor 15 Suppresses Ferroptosis by Activating an NRF2/GPX4 Signal to Protect against Folic Acid-Induced Acute Kidney Injury.
CXXC finger protein 1 (CFP1) bridges the reshaping of genomic H3K4me3 signature to the advancement of lung adenocarcinoma.
Ketogenic diet and β-Hydroxybutyrate alleviate ischemic brain injury in mice via an IRAKM-dependent pathway.
An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption.
PAQR5 inhibits the growth and metastasis of clear cell renal cell carcinoma by suppressing the JAK/STAT3 signaling pathway.
Dysregulation of iron homeostasis by TfR-1 renders EZH2 wild type diffuse large B-cell lymphoma resistance to EZH2 inhibition.
Cav3.2 T-Type calcium channels downregulation attenuates bone cancer pain induced by inhibiting IGF-1/HIF-1α signaling pathway in the rat spinal cord.
SEMA3B-AS1 suppresses colorectal carcinoma progression by inhibiting Semaphorin 3B-dependent VEGF signaling pathway activation.
Filamin A facilitates NLRP3 inflammasome activation during arsenic-induced nonalcoholic steatohepatitis.
3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis.
Multiple sevoflurane exposures during mid-trimester induce neurotoxicity in the developing brain initiated by 15LO2-Mediated ferroptosis.
SAFB associates with nascent RNAs and can promote gene expression in mouse embryonic stem cells.
Metformin Promotes Proliferation of Mouse Female Germline Stem Cells by Histone Acetylation Modification of Traf2.
The PRX-1/TLR4 axis promotes hypoxia-induced radiotherapy resistance in non-small cell lung cancer by targeting the NF-κB/p65 pathway.
NKRF in Cardiac Fibroblasts Protects against Cardiac Remodeling Post-Myocardial Infarction via Human Antigen R.
LINC00922 decoys SIRT3 to facilitate the metastasis of colorectal cancer through up-regulation the H3K27 crotonylation of ETS1 promoter.
Identification of RECK as a protective prognostic indicator and a tumor suppressor through regulation of the ERK/MAPK signaling pathway in gastric cancer.
Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.
The ubiquitin E3 ligase MDM2 induces chemoresistance in colorectal cancer by degradation of ING3.
A mitochondrial EglN1-AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress.
Ginsenoside Rg5 promotes wound healing in diabetes by reducing the negative regulation of SLC7A11 on the efferocytosis of dendritic cells.
Targeting histone deacetylase suppresses tumor growth through eliciting METTL14-modified m(6) A RNA methylation in ocular melanoma.
SIRT6 mediated histone H3K9ac deacetylation involves myocardial remodelling through regulating myocardial energy metabolism in TAC mice.
Knockdown of repulsive guidance molecule a promotes polarization of microglia into an anti-inflammatory phenotype after oxygen-glucose deprivation-reoxygenation in vitro.
A Novel EYA1 Mutation Causing Alternative RNA Splicing in a Chinese Family With Branchio-Oto Syndrome: Implications for Molecular Diagnosis and Clinical Application.
A large-scale transcriptional analysis reveals herb-derived ginsenoside F2 suppressing hepatocellular carcinoma via inhibiting STAT3.
KLF5/MDM2 Axis Modulates Oxidative Stress and Epithelial-Mesenchymal Transition in Human Lens Epithelial Cells: The Role in Diabetic Cataract.
Design, synthesis, and bioactivity evaluation of novel amide/sulfonamide derivatives as potential anti-inflammatory agents against acute lung injury and ulcerative colitis.
Covalent Peptide LSD1 Inhibitor Specifically Recognizes Cys360 in the Enzyme-Active Region.
Small molecule activates citrullination through targeting PAD2.
Inhibiting MEK1 R189 citrullination enhances the chemosensitivity of docetaxel to multiple tumour cells.
Cinnamaldehyde Alleviates Bone Loss by Targeting Oxidative Stress and Mitochondrial Damage via the Nrf2/HO-1 Pathway in BMSCs and Ovariectomized Mice.
Regulation of the Hippo/YAP axis by CXCR7 in the tumorigenesis of gastric cancer.
MAGL inhibition relieves synovial inflammation and pain via regulating NOX4-Nrf2 redox balance in osteoarthritis.
Silencing of adipocyte enhancer-binding protein 1 (AEBP1) alleviates renal fibrosis in vivo and in vitro via inhibition of the β-catenin signaling pathway.
Novel insights into the angiogenic function of JMJD2B in diabetic hind limb ischemia: involvement of activating Wnt/β-catenin pathway.
Lycopene inhibits endothelial-to-mesenchymal transition of choroidal vascular endothelial cells in laser-induced mouse choroidal neovascularization.
N6-Methyladenosine-Mediated Up-Regulation of FZD10 Regulates Liver Cancer Stem Cells' Properties and Lenvatinib Resistance Through WNT/β-Catenin and Hippo Signaling Pathways.
NSD3, a member of nuclear receptor-binding SET domain family, is a potential prognostic biomarker for pancreatic cancer.
PcEiger links the Imd/Relish pathway to ROS production in the intestine of the red swamp crayfish.
Anti-Neuroinflammatory Meroterpenoids from a Chinese Collection of the Brown Alga Sargassum siliquastrum.
Metformin promotes female germline stem cell proliferation by upregulating Gata-binding protein 2 with histone β-hydroxybutyrylation.
Wei-Tong-Xin ameliorated cisplatin-induced mitophagy and apoptosis in gastric antral mucosa by activating the Nrf2/HO-1 pathway.
Hepatocyte ferroptosis contributes to anti-tuberculosis drug-induced liver injury: Involvement of the HIF-1α/SLC7A11/GPx4 axis.
Eosinophils protect against pulmonary hypertension through 14-HDHA and 17-HDHA.
A Physiologically Responsive Nanocomposite Hydrogel for Treatment of Head and Neck Squamous Cell Carcinoma via Proteolysis-Targeting Chimeras Enhanced Immunotherapy.
Abamectin causes cardiac dysfunction in carp via inhibiting redox equilibrium and resulting in immune inflammatory response and programmed cell death.
Neuroprotective effect of a Keap1-Nrf2 Protein-Protein Inter-action inhibitor on cerebral Ischemia/Reperfusion injury.
1,25(OH)(2) D(3) induced vitamin D receptor signaling negatively regulates endoplasmic reticulum-associated degradation (ERAD) and androgen receptor signaling in human prostate cancer cells.
PABPN1 regulates mRNA alternative polyadenylation to inhibit bladder cancer progression.
9-Butyl-Harmol Exerts Antiviral Activity against Newcastle Disease Virus through Targeting GSK-3β and HSP90β.
Nuclear PD-L1 promotes EGR1-mediated angiogenesis and accelerates tumorigenesis.
Baicalin facilitates remyelination and suppresses neuroinflammation in rats with chronic cerebral hypoperfusion by activating Wnt/β-catenin and inhibiting NF-κB signaling.
Evolutionarily distinct and sperm-specific supersized chromatin loops are marked by Helitron transposons in Xenopus tropicalis.
Selective Targeting of Class I HDAC Reduces Microglial Inflammation in the Entorhinal Cortex of Young APP/PS1 Mice.
LNX2 involves in the role of ghrelin to promote the neuronal differentiation of adipose tissue-derived mesenchymal stem cells.
Atorvastatin prevents endoplasmic reticulum stress-mediated apoptosis via the Nrf2/HO-1 signaling pathway in TBI mice.
Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells.
Targeting HMGA1 contributes to immunotherapy in aggressive breast cancer while suppressing EMT.
Nuciferine improves random skin flap survival via TFEB-mediated activation of autophagy-lysosomal pathway.
Syk-dependent alternative homologous recombination activation promotes cancer resistance to DNA targeted therapy.
Discovery of a New-Generation S-Adenosylmethionine-Noncompetitive Covalent Inhibitor Targeting the Lysine Methyltransferase Enhancer of Zeste Homologue 2.
TRIM5α recruits HDAC1 to p50 and Sp1 and promotes H3K9 deacetylation at the HIV-1 LTR.
Identification of the E2F1-RAD51AP1 axis as a key factor in MGMT-methylated GBM TMZ resistance.
20-hydroxyecdysone reprograms amino acid metabolism to support the metamorphic development of Helicoverpa armigera.
Organization, genomic targeting, and assembly of three distinct SWI/SNF chromatin remodeling complexes in Arabidopsis.
Structural basis of the interaction between BCL9-Pygo and LDB-SSBP complexes in assembling the Wnt enhanceosome.
SMYD2 inhibition-mediated hypomethylation of Ku70 contributes to impaired nonhomologous end joining repair and antitumor immunity.
Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis.
Kinsenoside alleviates oxidative stress-induced blood-brain barrier dysfunction via promoting Nrf2/HO-1 pathway in ischemic stroke.
Fibroblast growth factor 21 (FGF21) attenuates tacrolimus-induced hepatic lipid accumulation through transcription factor EB (TFEB)-regulated lipophagy.
Epstein-Barr Virus Envelope Glycoprotein gp110 Inhibits IKKi-Mediated Activation of NF-κB and Promotes the Degradation of β-Catenin.
Inhibiting HIF-1 signaling alleviates HTRA1-induced RPE senescence in retinal degeneration.
Karyopherin Subunit Alpha 1 Enhances the Malignant Behaviors of Colon Cancer Cells via Promoting Nuclear Factor-κB p65 Nuclear Translocation.
Mangiferin Protects DNase 2 Abundance via Nrf2 Activation to Prevent Cytosolic mtDNA Accumulation during Liver Injury.
Direct Knockdown of PDZ and LIM Domain 1 Using an Adenoviral Delivery System Accelerates Osteogenesis and Fracture Healing in Mice.
Radiation resistance of cancer cells caused by mitochondrial dysfunction depends on SIRT3-mediated mitophagy.
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity.
Dark repair of sunlight-inactivated tetracycline-resistant bacteria: Mechanisms and important role of bacteria in viable but non-culturable state.
The inhibition of FKBP5 protects β-cell survival under inflammation stress via AKT/FOXO1 signaling.
The Novel Role of Zfp296 in Mammalian Embryonic Genome Activation as an H3K9me3 Modulator.
USP15 promotes pulmonary vascular remodeling in pulmonary hypertension in a YAP1/TAZ-dependent manner.
The novel sustained 3-hydroxybutyrate donor poly-D-3-hydroxybutyric acid prevents inflammatory bowel disease through upregulation of regulatory T-cells.
Halofuginone ameliorates systemic lupus erythematosus by targeting Blk in myeloid-derived suppressor cells.
Yishen-Qingli-Huoxue formula attenuates renal fibrosis by inhibiting indoxyl sulfate via AhR/snai1 signaling.
Zhen Wu decoction represses renal fibrosis by invigorating tubular NRF2 and TFAM to fuel mitochondrial bioenergetics.
DOT1L Epigenetically Regulates Autophagy and Mitochondria Fusion in Cell Lines of Renal Cancer.
A Novel in Duck Myoblasts: The Transcription Factor Retinoid X Receptor Alpha (RXRA) Inhibits Lipid Accumulation by Promoting CD36 Expression.
Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression.
ER stress-enhanced HMGA2 plays an important role in Cr (VI)-induced glycolysis and inhibited oxidative phosphorylation by targeting the transcription of ATF4.
SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.
Low-Dose Sodium Salicylate Promotes Ovulation by Regulating Steroids via CYP17A1.
FTO-dependent m(6)A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.
Discovery of IHMT-337 as a potent irreversible EZH2 inhibitor targeting CDK4 transcription for malignancies.
Embryonic 6:2 FTOH exposure causes reproductive toxicity by disrupting the formation of the blood-testis barrier in offspring mice.
Glioma-derived LRIG3 interacts with NETO2 in tumor-associated macrophages to modulate microenvironment and suppress tumor growth.
FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.
Novel lncRNA-prader willi/angelman region RNA, SNRPN neighbour (PWARSN) aggravates tubular epithelial cell pyroptosis by regulating TXNIP via dual way in diabetic kidney disease.
Progesterone regulates the endoplasmic reticulum-associated degradation and Unfolded Protein Response axis by mimicking the androgenic stimulation in prostate cancer cells.
Catalpol Ameliorates Oxidative Stress and Neuroinflammation after Traumatic Brain Injury in Rats.
TRIM24 is critical for the cellular response to DNA double-strand breaks through regulating the recruitment of MRN complex.
SPON2 promotes the bone metastasis of lung adenocarcinoma via activation of the NF-κB signaling pathway.
NF-κB p65 and SETDB1 expedite lipopolysaccharide-induced intestinal inflammation in mice by inducing IRF7/NLR-dependent macrophage M1 polarization.
Isothiocyanates attenuate immune checkpoint blockage therapy in gastric cancer via induction of PD-L1 expression.
LIM and Cysteine-Rich Domains 1 Promotes Transforming Growth Factor β1-Induced Epithelial-Mesenchymal Transition in Human Kidney 2 Cells.
Non-Esterified Fatty Acid-Induced Apoptosis in Bovine Granulosa Cells via ROS-Activated PI3K/AKT/FoxO1 Pathway.
Aryl hydrocarbon receptor dependent anti-inflammation and neuroprotective effects of tryptophan metabolites on retinal ischemia/reperfusion injury.
Multi-Omics Approaches for Revealing the Epigenetic Regulation of Histone H3.1 during Spermatogonial Stem Cell Differentiation In Vitro.
Upregulated GPRC5A disrupting the Hippo pathway promotes the proliferation and migration of pancreatic cancer cells via the cAMP-CREB axis.
TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
Atf7ip Inhibits Osteoblast Differentiation via Negative Regulation of the Sp7 Transcription Factor.
PSAT1 positively regulates the osteogenic lineage differentiation of periodontal ligament stem cells through the ATF4/PSAT1/Akt/GSK3β/β-catenin axis.
Exendin-4 alleviates myocardial ischemia reperfusion injury by enhancing autophagy through promoting nuclear translocation of TFEB.
2-Undecanone alleviates asthma by inhibiting NF-κB pathway.
Dimethyl fumarate ameliorates erectile dysfunction in bilateral cavernous nerve injury rats by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis of nerve via activation of Nrf2/HO-1 signaling pathway.
BDH1-mediated LRRC31 regulation dependent on histone lysine β-hydroxybutyrylation to promote lung adenocarcinoma progression.
Curcumin Alleviates Hepatic Ischemia-Reperfusion Injury by Inhibiting Neutrophil Extracellular Traps Formation.
HIF-1α promotes astrocytic production of macrophage migration inhibitory factor following spinal cord injury.
Brusatol enhances MEF2A expression to inhibit RCC progression through the Wnt signalling pathway in renal cell carcinoma.
Delineating the early dissemination mechanisms of acral melanoma by integrating single-cell and spatial transcriptomic analyses.
The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells.
E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC.
H2O2-dependent oxidation of the transcription factor GmNTL1 promotes salt tolerance in soybean.
m(6)A methylation-mediated PGC-1α contributes to ferroptosis via regulating GSTK1 in arsenic-induced hepatic insulin resistance.
Histone demethylase KDM4B accelerates the progression of glioblastoma via the epigenetic regulation of MYC stability.
Squalene epoxidase promotes breast cancer progression by regulating CCNB1 protein stability.
Cyclic helix B peptide alleviates proinflammatory cell death and improves functional recovery after traumatic spinal cord injury.
O‑GlcNAcylation mediates endometrial cancer progression by regulating the Hippo‑YAP pathway.
Glutamine metabolic microenvironment drives M2 macrophage polarization to mediate trastuzumab resistance in HER2-positive gastric cancer.
Adenosine receptor A2b confers ovarian cancer survival and PARP inhibitor resistance through IL-6-STAT3 signalling.
Lnc-PPP2R1B Mediates the Alternative Splicing of PPP2R1B by Interacting and Stabilizing HNRNPLL and Promotes Osteogenesis of MSCs.
Novel treatment and insight for irradiation-induced injuries: Dibucaine ameliorates irradiation-induced testicular injury by inhibiting fatty acid oxidation in primary Leydig cells.
AKBA alleviates experimental pancreatitis by inhibiting oxidative stress in Macrophages through the Nrf2/HO-1 pathway.
LMCD1 is involved in tubulointerstitial inflammation in the early phase of renal fibrosis by promoting NFATc1-mediated NLRP3 activation.
NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.
Mitochondrial carrier 1 (MTCH1) governs ferroptosis by triggering the FoxO1-GPX4 axis-mediated retrograde signaling in cervical cancer cells.
Loss of N-acetylglucosaminyl transferase V is involved in the impaired osteogenic differentiation of bone marrow mesenchymal stem cells.
Transcriptional variation in Babesia gibsoni (Wuhan isolate) between in vivo and in vitro cultures in blood stage.
Tumor-Associated Extracellular Microvesicles with Fluorine-Modified Carbohydrate Antigens Trigger a Stronger Antitumor Immune Response.
LncRNA DGCR5-encoded polypeptide RIP aggravates SONFH by repressing nuclear localization of β-catenin in BMSCs.
ATF7IP2, a meiosis-specific partner of SETDB1, is required for proper chromosome remodeling and crossover formation during spermatogenesis.
Subcellular localization shapes the fate of RNA polymerase III.
POGZ suppresses 2C transcriptional program and retrotransposable elements.
Targeted deletion of von-Hippel-Lindau in the proximal tubule conditions the kidney against early diabetic kidney disease.
Inhibition of VCP modulates NF-κB signaling pathway to suppress multiple myeloma cell proliferation and osteoclast differentiation.
HOXA1 participates in VSMC-to-macrophage-like cell transformation via regulation of NF-κB p65 and KLF4: a potential mechanism of atherosclerosis pathogenesis.
Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.
Muscone promotes functional recovery by facilitating microglia polarization into M2 phenotype through PPAR-γ pathway after ischemic stroke.
Loss of RAGE prevents chronic intermittent hypoxia-induced nonalcoholic fatty liver disease via blockade of NF-кB pathway.
HMGCL-induced β-hydroxybutyrate production attenuates hepatocellular carcinoma via DPP4-mediated ferroptosis susceptibility.
LINC00669 promotes lung adenocarcinoma growth by stimulating the Wnt/β-catenin signaling pathway.
Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3β/Nrf2 signaling-mediated ferroptosis in vivo and in vitro.
rFGF4 alleviates lipopolysaccharide-induced acute lung injury by inhibiting the TLR4/NF-κB signaling pathway.
YTHDF1 phase separation triggers the fate transition of spermatogonial stem cells by activating the IκB-NF-κB-CCND1 axis.
Nuclear translocation of cGAS orchestrates VEGF-A-mediated angiogenesis.
Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis.
A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA.
A neuroprotective role of Ufmylation through Atg9 in the aging brain of Drosophila.
Asparagine starvation suppresses histone demethylation through iron depletion.
Neofunctionalization of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes.
RNA Pol II preferentially regulates ribosomal protein expression by trapping disassociated subunits.
Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma.
Effects of Spatial Expression of Activating Transcription Factor 4 on the Pathogenicity of Two Phenotypes of Bovine Viral Diarrhea Virus by Regulating the Endoplasmic Reticulum-Mediated Autophagy Process.
Berberine promotes IGF2BP3 ubiquitination by TRIM21 to induce G1/S phase arrest in colorectal cancer cells.
CCPG1 recognizes endoplasmic reticulum luminal proteins for selective ER-phagy.
Fructose Induces Insulin Resistance of Gestational Diabetes Mellitus in Mice via the NLRP3 Inflammasome Pathway.
Guanxinping Tablets Inhibit ET-1-Induced Proliferation and Migration of MOVAS by Suppressing Activated PI3K/Akt/NF-κB Signaling Cascade.
Qingfei Tongluo Formula Mitigates Mycoplasma pneumoniae Infection via the PERK Signaling Pathway.
Inhibition of APE1 Expression Enhances the Antitumor Activity of Olaparib in Triple-Negative Breast Cancer.
Deletion of ACLY Disrupts Histone Acetylation and IL-10 Secretion in Trophoblasts, Which Inhibits M2 Polarization of Macrophages: A Possible Role in Recurrent Spontaneous Abortion.
Maltol Promotes Mitophagy and Inhibits Oxidative Stress via the Nrf2/PINK1/Parkin Pathway after Spinal Cord Injury.
Downregulation of lncRNA APCDD1L-AS1 due to DNA hypermethylation and loss of VHL protein expression promotes the progression of clear cell renal cell carcinoma.
Yap is essential for uterine decidualization through Rrm2/GSH/ROS pathway in response to Bmp2.
HB-EGF induces mitochondrial dysfunction via estrogen hypersecretion in granulosa cells dependent on cAMP-PKA-JNK/ERK-Ca(2+)-FOXO1 pathway.
Caspase-1-mediated extracellular vesicles derived from pyroptotic alveolar macrophages promote inflammation in acute lung injury.
B16 Membrane-Coated Vesicles for Combined Photodynamic Therapy and Immunotherapy Shift Immune Microenvironment of Melanoma.
Superparamagnetic Iron Oxide Nanoparticles Protect Human Gingival Fibroblasts from Porphyromonas gingivalis Invasion and Inflammatory Stimulation.
CCL25 Inhibition Alleviates Sepsis-Induced Acute Lung Injury and Inflammation.
DNA 6mA Demethylase ALKBH1 Orchestrates Fatty Acid Metabolism and Suppresses Diet-Induced Hepatic Steatosis.
Resveratrol reduces inflammatory response and detrimental effects in chronic cerebral hypoperfusion by down-regulating stimulator of interferon genes/TANK-binding kinase 1/interferon regulatory factor 3 signaling.
Transcriptional and H3K27ac related genome profiles in oral squamous cell carcinoma cells treated with metformin.
The BcLAE1 is involved in the regulation of ABA biosynthesis in Botrytis cinerea TB-31.
Loss of Cep72 affects the morphology of spermatozoa in mice.
EST12 regulates Myc expression and enhances anti-mycobacterial inflammatory response via RACK1-JNK-AP1-Myc immune pathway.
Acetyl-11-Keto-Beta Boswellic Acid (AKBA) Protects Lens Epithelial Cells Against H(2)O(2)-Induced Oxidative Injury and Attenuates Cataract Progression by Activating Keap1/Nrf2/HO-1 Signaling.
GSK3β-dependent lysosome biogenesis: An effective pathway to mitigate renal fibrosis with LM49.
Cyclophosphamide Induces the Ferroptosis of Tumor Cells Through Heme Oxygenase-1.
Characterization and subcellular localization of Alongshan virus proteins.
PPAR-γ integrates obesity and adipocyte clock through epigenetic regulation of Bmal1.
Reversion of methionine addiction of osteosarcoma cells to methionine independence results in loss of malignancy, modulation of the epithelial-mesenchymal phenotype and alteration of histone-H3 lysine-methylation.
Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway.
Stimulator of Interferon Genes (STING) Promotes Staphylococcus aureus-Induced Extracellular Traps Formation via the ROS-ERK Signaling Pathway.
Manganese-Induced Oxidative Stress Contributes to Intestinal Lipid Deposition via the Deacetylation of PPARγ at K339 by SIRT1.
Biosynthesis of a water solubility-enhanced succinyl glucoside derivative of luteolin and its neuroprotective effect.
Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.
TRIM36 inhibits tumorigenesis through the Wnt/β-catenin pathway and promotes caspase-dependent apoptosis in hepatocellular carcinoma.
TRIM46 aggravated high glucose-induced hyper permeability and inflammatory response in human retinal capillary endothelial cells by promoting IκBα ubiquitination.
The transcriptional repressors VAL1 and VAL2 mediate genome-wide recruitment of the CHD3 chromatin remodeler PICKLE in Arabidopsis.
Fatostatin inhibits SREBP2-mediated cholesterol uptake via LDLR against selective estrogen receptor α modulator-induced hepatic lipid accumulation.
Role of PARP-1 in Human Cytomegalovirus Infection and Functional Partners Encoded by This Virus.
1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42) inhibits cell proliferation and induces apoptosis via inhibiting ALK and its downstream pathways in Karpas299 cells.
MCTR1 inhibits ferroptosis by promoting NRF2 expression to attenuate hepatic ischemia-reperfusion injury.
Notch4 affects the proliferation and differentiation of deer antler chondrocytes through the Smad3/lncRNA27785.1 axis.
A novel O(2)- (2,4-dinitrophenyl) diazeniumdiolate inhibits hepatocellular carcinoma migration, invasion, and EMT through the Wnt/β-catenin pathway.
MARCH1 promotes the growth and maintaining of stem cell-like characteristics of gastric cancer cells by activating the Wnt/β-catenin signaling pathway.
Sestrin2 attenuates renal damage by regulating Hippo pathway in diabetic nephropathy.
SAC3D1 activates Wnt/β‑catenin signalling in hepatocellular carcinoma.
Effect of propiconazole on neutrophil extracellular traps formation: Assessing the role of autophagy.
Fucoidan inhibits EGFR redistribution and potentiates sorafenib to overcome sorafenib-resistant hepatocellular carcinoma.
CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment.
ITGA2 overexpression inhibits DNA repair and confers sensitivity to radiotherapies in pancreatic cancer.
An assembly-inducing PDC enabling the efficient nuclear delivery of nucleic acid for cancer stem-like cell suppression.
RBCK1 is an endogenous inhibitor for triple negative breast cancer via hippo/YAP axis.
Malvidin protects against lipopolysaccharide-induced acute liver injury in mice via regulating Nrf2 and NLRP3 pathways and suppressing apoptosis and autophagy.
The Effect of Circumscribed Exposure to the Pan-Aurora Kinase Inhibitor VX-680 on Proliferating Euploid Cells.
CGG repeat expansion in NOTCH2NLC causes mitochondrial dysfunction and progressive neurodegeneration in Drosophila model.
Difenoconazole disrupts the blood-brain barrier and results in neurotoxicity in carp by inhibiting the Nrf2 pathway mediated ROS accumulation.
CircNFIX regulates chondrogenesis and cartilage homeostasis by targeting the miR758-3p/KDM6A axis.
Stabilizing and upregulating Axin with tankyrase inhibitor reverses 5-fluorouracil chemoresistance and proliferation by targeting the WNT/caveolin-1 axis in colorectal cancer cells.
Small immune effectors coordinate peptidoglycan-derived immunity to regulate intestinal bacteria in shrimp.
A systems biological analysis of the ATF4-GADD34-CHOP regulatory triangle upon endoplasmic reticulum stress.
Grossamide attenuates inflammation by balancing macrophage polarization through metabolic reprogramming of macrophages in mice.
Capsaicin suppresses hepatocarcinogenesis by inhibiting the stemness of hepatic progenitor cells via SIRT1/SOX2 signaling pathway.
Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling.
Regulation of ZO-1 on β-catenin mediates sulforaphane suppressed colorectal cancer stem cell properties in colorectal cancer.
Taurine stimulates protein synthesis and proliferation of C2C12 myoblast cells through the PI3K-ARID4B-mTOR pathway.
O-GlcNAcylation of SIRT1 Protects against Cold Stress-Induced Skeletal Muscle Damage via Amelioration of Mitochondrial Homeostasis.
Naringenin Promotes Myotube Formation and Maturation for Cultured Meat Production.
Deficiency of CD93 exacerbates inflammation-induced activation and migration of BV2 microglia by regulating the TAK1/NF-κB pathway.
Overexpression of Tfap2a in Mouse Oocytes Impaired Spindle and Chromosome Organization.
The H2A.Z-KDM1A complex promotes tumorigenesis by localizing in the nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells.
Leonurine inhibits the TXNIP/NLRP3 and NF-κB pathways via Nrf2 activation to alleviate carrageenan-induced pleurisy in mice.
Mitochondrial transcription factor B2 overexpression increases M2 macrophage infiltration via cytosolic mitochondrial DNA-stimulated Interleukin-6 secretion in ovarian cancer.
Characterization of the Eimeria tenella rhoptry protein with a nuclear localization sequence (EtROP30).
Genome-wide gain-of-function screening identifies EZH2 mediating resistance to PI3Kα inhibitors in oesophageal squamous cell carcinoma.
POU6F1 cooperates with RORA to suppress the proliferation of lung adenocarcinoma by downregulation HIF1A signaling pathway.
Isoleucine stimulates mTOR and SREBP-1c gene expression for milk synthesis in mammary epithelial cells through BRG1-mediated chromatin remodelling.
Dysregulated lipid metabolism blunts the sensitivity of cancer cells to EZH2 inhibitor.
Attenuation of Activated eIF2α Signaling by ISRIB Treatment After Spinal Cord Injury Improves Locomotor Function.
iASPP is essential for HIF-1α stabilization to promote angiogenesis and glycolysis via attenuating VHL-mediated protein degradation.
DNA damage-induced translocation of mitochondrial factor HIGD1A into the nucleus regulates homologous recombination and radio/chemo-sensitivity.
Inhibition of translocator protein 18 kDa suppressed the progression of glioma via the ELAV-like RNA-binding protein 1/MAPK-activated protein kinase 3 axis.
Methionine and leucine induce ARID1A degradation to promote mTOR expression and milk synthesis in mammary epithelial cells.
Gut microbiota shapes social dominance through modulating HDAC2 in the medial prefrontal cortex.
Bisphenol A drives di(2-ethylhexyl) phthalate promoting thyroid tumorigenesis via regulating HDAC6/PTEN and c-MYC signaling.
LPS/Bcl3/YAP1 signaling promotes Sox9(+)HNF4α(+) hepatocyte-mediated liver regeneration after hepatectomy.
HMGB3 promotes PARP inhibitor resistance through interacting with PARP1 in ovarian cancer.
Targeting macrophage TFEB-14-3-3 epsilon Interface by naringenin inhibits abdominal aortic aneurysm.
Recruitment of DNA to tumor-derived microvesicles.
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix.
Overexpression of G Protein-Coupled Receptor 40 Protects Obesity-Induced Cardiomyopathy Through the SIRT1/LKB1/AMPK Pathway.
Mammalian PERIOD2 regulates H2A.Z incorporation in chromatin to orchestrate circadian negative feedback.
Deacetylation of Caveolin-1 by Sirt6 induces autophagy and retards high glucose-stimulated LDL transcytosis and atherosclerosis formation.
Dietary curcumin supplementation ameliorates placental inflammation in rats with intra-uterine growth retardation by inhibiting the NF-κB signaling pathway.
A novel ALG10/TGF-β positive regulatory loop contributes to the stemness of colorectal cancer.
Interaction of Nucleolin with the Fusion Protein of Avian Metapneumovirus Subgroup C Contributes to Viral Replication.
Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival.
The PRMT5-LSD1 axis confers Slug dual transcriptional activities and promotes breast cancer progression.
Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress.
TAZ ameliorates the microglia-mediated inflammatory response via the Nrf2-ROS-NF-κB pathway.
Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration.
Treatment of Membranous Nephropathy by Disulfiram through Inhibition of Podocyte Pyroptosis.
NLRP3 inflammasome triggers interleukin-37 release from human monocytes.
Berberine protects against palmitate induced beta cell injury via promoting mitophagy.
Vibrio splendidus flagellin C binds tropomodulin to induce p38 MAPK-mediated p53-dependent coelomocyte apoptosis in Echinodermata.
Procyanidins and its metabolites by gut microbiome improves insulin resistance in gestational diabetes mellitus mice model via regulating NF-κB and NLRP3 inflammasome pathway.
Design, synthesis and biological evaluation of (R)-5-methylpyrrolidin-2-ones as p300 bromodomain inhibitors with Anti-Tumor activities in multiple tumor lines.
Maackiain protects against sepsis via activating AMPK/Nrf2/HO-1 pathway.
The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice.
T-2 Toxin Induces Apoptotic Cell Death and Protective Autophagy in Mouse Microglia BV2 Cells.
Alphaherpesvirus US3 protein-mediated inhibition of the m6A mRNA methyltransferase complex.
Andrographolide protects bone marrow mesenchymal stem cells against glucose and serum deprivation under hypoxia via the NRF2 signaling pathway.
HDAC inhibitor quisinostat prevents estrogen deficiency-induced bone loss by suppressing bone resorption and promoting bone formation in mice.
CCL20/CCR6 axis mediates macrophages to promote proliferation and migration of ESCs by blocking autophagic flux in endometriosis.
NRF2 Serves a Critical Role in Regulation of Immune Checkpoint Proteins (ICPs) During Trophoblast Differentiation.
Effects of bamboo leaf extract intervention on the growth performance, antioxidant capacity, and hepatic apoptosis in suckling piglets.
miR‑30a‑5p induces the adipogenic differentiation of bone marrow mesenchymal stem cells by targeting FAM13A/Wnt/β‑catenin signaling in aplastic anemia.
Shoc2 recognizes bacterial flagellin and mediates antibacterial Erk/Stat signaling in an invertebrate.
Cyclic helix B peptide promotes random-pattern skin flap survival via TFE3-mediated enhancement of autophagy and reduction of ROS levels.
Wilforlide A ameliorates the progression of rheumatoid arthritis by inhibiting M1 macrophage polarization.
Irisin lowers blood pressure in Zucker diabetic rats by regulating the functions of renal angiotensin II type 1 receptor via the inhibition of the NF-κB signaling pathway.
Nuclear accumulation of KPNA2 impacts radioresistance through positive regulation of the PLSCR1-STAT1 loop in lung adenocarcinoma.
Extracellular vesicle-mediated delivery of circDYM alleviates CUS-induced depressive-like behaviours.
Extent and Instability of Trimethylation of Histone H3 Lysine Increases With Degree of Malignancy and Methionine Addiction.
Immobilized Titanium (IV) Ion Affinity Chromatography Contributes to Efficient Proteomics Analysis of Cellular Nucleic Acid-Binding Proteins.
ERK/p38/ROS burst responses to environmentally relevant concentrations of diphenyl phosphate-evoked neutrophil extracellular traps formation: Assessing the role of autophagy.
Bclaf1 regulates c-FLIP expression and protects cells from TNF-induced apoptosis and tissue injury.
Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.
Nrf2 loss of function exacerbates endoplasmic reticulum stress-induced apoptosis in TBI mice.
SETDB1 Regulates Porcine Spermatogonial Adhesion and Proliferation through Modulating MMP3/10 Transcription.
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN.
FSH inhibits autophagy and lysosomal biogenesis to regulate protein degradation in cultured goat Sertoli cells.
Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation.
SPOCK1 promotes metastasis in pancreatic cancer via NF-κB-dependent epithelial-mesenchymal transition by interacting with IκB-α.
The role of junctional adhesion molecule-C in trophoblast differentiation and function during normal pregnancy and preeclampsia.
Copper (Cu) induced changes of lipid metabolism through oxidative stress-mediated autophagy and Nrf2/PPARγ pathways.
Toddalolactone protects against osteoarthritis by ameliorating chondrocyte inflammation and suppressing osteoclastogenesis.
TJ-M2010-5, A self-developed MyD88 inhibitor, attenuates liver fibrosis by inhibiting the NF-κB pathway.
The HDAC inhibitor GCJ-490A suppresses c-Met expression through IKKα and overcomes gefitinib resistance in non-small cell lung cancer.
Blocking iASPP/Nrf2/M-CSF axis improves anti-cancer effect of chemotherapy-induced senescence by attenuating M2 polarization.
Acquired temozolomide resistance in MGMT(low) gliomas is associated with regulation of homologous recombination repair by ROCK2.
Dietary Selenium Alleviated Mouse Liver Oxidative Stress and NAFLD Induced by Obesity by Regulating the KEAP1/NRF2 Pathway.
Liquidambaric acid inhibits Wnt/β-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2.
Blockade of Nuclear β-Catenin Signaling via Direct Targeting of RanBP3 with NU2058 Induces Cell Senescence to Suppress Colorectal Tumorigenesis.
Kynurenine/Aryl Hydrocarbon Receptor Modulates Mitochondria-Mediated Oxidative Stress and Neuronal Apoptosis in Experimental Intracerebral Hemorrhage.
Combined HASPIN and mTOR inhibition is synergistic against KRAS-driven carcinomas.
Regulation of host factor γ-H2AX level and location by enterovirus A71 for viral replication.
D-Mannose ameliorates DNCB-induced atopic dermatitis in mice and TNF-α-induced inflammation in human keratinocytes via mTOR/NF-κB pathway.
Gut dysbacteriosis attenuates resistance to Mycobacterium bovis infection by decreasing cyclooxygenase 2 to inhibit endoplasmic reticulum stress.
The A-to-I editing of KPC1 promotes intrahepatic cholangiocarcinoma by attenuating proteasomal processing of NF-κB1 p105 to p50.
The RNA polymerase of cytoplasmically replicating Zika virus binds with chromatin DNA in nuclei and regulates host gene transcription.
Nucleophagic Degradation of Progerin Ameliorates Defenestration in Liver Sinusoidal Endothelium Due to SIRT1-Mediated Deacetylation of Nuclear LC3.
RNF31 represses cell progression and immune evasion via YAP/PD-L1 suppression in triple negative breast Cancer.
MALAT1 modulates alternative splicing by cooperating with the splicing factors PTBP1 and PSF.
Deficiency of CFB attenuates renal tubulointerstitial damage by inhibiting ceramide synthesis in diabetic kidney disease.
Proteomic Comparison of Three Wild-Type Pseudorabies Virus Strains and the Attenuated Bartha Strain Reveals Reduced Incorporation of Several Tegument Proteins in Bartha Virions.
Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Targeting the Gut Microbiota Accompanied by the TLR4/NF-κB/NLRP3 Cascade Response In Vivo.
Verteporfin inhibits the dedifferentiation of tubular epithelial cells via TGF-β1/Smad pathway but induces podocyte loss in diabetic nephropathy.
Melatonin attenuates bone cancer pain via the SIRT1/HMGB1 pathway.
circNup188/miR-760-3p/Map3k8 axis regulates inflammation in cerebral ischemia.
MgIG exerts therapeutic effects on crizotinib-induced hepatotoxicity by limiting ROS-mediated autophagy and pyroptosis.
GPR108 is required for gambogic acid inhibiting NF-κB signaling in cancer.
KSHV RTA antagonizes SMC5/6 complex-induced viral chromatin compaction by hijacking the ubiquitin-proteasome system.
Potential dual protective effects of melatonin on spermatogonia against hexavalent chromium.
RP105 protects against ischemic and septic acute kidney injury via suppressing TLR4/NF-κB signaling pathways.
Global phosphoproteomic analysis identified key kinases regulating male meiosis in mouse.
MicroRNA-363-3p/sphingosine-1-phosphate receptor 1 axis inhibits sepsis-induced acute lung injury via the inactivation of nuclear factor kappa-B ligand signaling.
Motoneurons innervation determines the distinct gene expressions in multinucleated myofibers.
Cornuside Is a Potential Agent against Alzheimer's Disease via Orchestration of Reactive Astrocytes.
Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer's disease.
Protective Effect of Cardiomyocyte-Specific Prolyl-4-Hydroxylase 2 Inhibition on Ischemic Injury in a Mouse MI Model.
Flavonoid 4,4'-dimethoxychalcone induced ferroptosis in cancer cells by synergistically activating Keap1/Nrf2/HMOX1 pathway and inhibiting FECH.
MiR-200c-3p inhibits LPS-induced M1 polarization of BV2 cells by targeting RIP2.
HDAC3 inhibition improves urinary-concentrating defect in hypokalaemia by promoting AQP2 transcription.
Tumor-promoting mechanisms of macrophage-derived extracellular vesicles-enclosed microRNA-660 in breast cancer progression.
Hepatoprotective Effects of Albumin-Encapsulated Nanoparticles of a Curcumin Derivative COP-22 against Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Injury in Mice.
Linkage of methionine addiction, histone lysine hypermethylation, and malignancy.
Mitochondrial Proteins Unveil the Mechanism by Which Physical Exercise Ameliorates Memory, Learning and Motor Activity in Hypoxic Ischemic Encephalopathy Rat Model.
Histone chaperone HIRA complex regulates retrotransposons in embryonic stem cells.
GLIS Family Zinc Finger 1 was First Linked With Preaxial Polydactyly I in Humans by Stepwise Genetic Analysis.
NAP1L5 Promotes Nucleolar Hypertrophy and Is Required for Translation Activation During Cardiomyocyte Hypertrophy.
GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation.
Tanshinone I Mitigates Steroid-Induced Osteonecrosis of the Femoral Head and Activates the Nrf2 Signaling Pathway in Rats.
Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo.
Attenuated lncRNA NKILA Enhances the Secretory Function of Airway Epithelial Cells Stimulated by Mycoplasma pneumoniae via NF-κB.
Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.
Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway.
miRNA-27a Transcription Activated by c-Fos Regulates Myocardial Ischemia-Reperfusion Injury by Targeting ATAD3a.
Buyang Huanwu Decoction Enhances Revascularization via Akt/GSK3β/NRF2 Pathway in Diabetic Hindlimb Ischemia.
Identification of Histone Modifications Reveals a Role of H2b Monoubiquitination in Transcriptional Regulation of dmrt1 in Monopterus albus.
GABAB receptor inhibits tumor progression and epithelial-mesenchymal transition via the regulation of Hippo/YAP1 pathway in colorectal cancer.
ITGB1 enhances the Radioresistance of human Non-small Cell Lung Cancer Cells by modulating the DNA damage response and YAP1-induced Epithelial-mesenchymal Transition.
Discovery of a novel HDACi structure that inhibits the proliferation of ovarian cancer cells in vivo and in vitro.
Psychostimulants and opioids differentially influence the epigenetic modification of histone acetyltransferase and histone deacetylase in astrocytes.
ADAM17 and NF-κB p65 form a positive feedback loop that facilitates human esophageal squamous cell carcinoma cell viability.
Lovastatin Alleviates α-Synuclein Aggregation and Phosphorylation in Cellular Models of Synucleinopathy.
Clock Gene Nr1d1 Alleviates Retinal Inflammation Through Repression of Hmga2 in Microglia.
Ulinastatin protects against acetaminophen-induced liver injury by alleviating ferroptosis via the SIRT1/NRF2/HO-1 pathway.
Calcitriol Alleviates MPP(+)- and MPTP-Induced Parthanatos Through the VDR/PARP1 Pathway in the Model of Parkinson's Disease.
Shenkang Injection and Its Three Anthraquinones Ameliorates Renal Fibrosis by Simultaneous Targeting IƙB/NF-ƙB and Keap1/Nrf2 Signaling Pathways.
Chinese Herbal Preparation SaiLuoTong Alleviates Brain Ischemia via Nrf2 Antioxidation Pathway-Dependent Cerebral Microvascular Protection.
TAS2R16 Activation Suppresses LPS-Induced Cytokine Expression in Human Gingival Fibroblasts.
Neutrophil Extracellular Traps Caused by Gut Leakage Trigger the Autoimmune Response in Nonobese Diabetic Mice.
Ras-Related C3 Botulinum Toxin Substrate 1 Combining With the Mixed Lineage Kinase 3- Mitogen-Activated Protein Kinase 7- c-Jun N-Terminal Kinase Signaling Module Accelerates Diabetic Nephropathy.
Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.
Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway.
Propofol Inhibits Ischemia/Reperfusion-Induced Cardiotoxicity Through the Protein Kinase C/Nuclear Factor Erythroid 2-Related Factor Pathway.
Dietary Inorganic Nitrate Protects Hepatic Ischemia-Reperfusion Injury Through NRF2-Mediated Antioxidative Stress.
Proteomic analysis of lung cancer cells reveals a critical role of BCAT1 in cancer cell metastasis.
Phenethyl Isothiocyanate Enhances the Cytotoxic Effects of PARP Inhibitors in High-Grade Serous Ovarian Cancer Cells.
Nox2 impairs VEGF-A-induced angiogenesis in placenta via mitochondrial ROS-STAT3 pathway.
The scaffold protein IQGAP1 links heat-induced stress signals to alternative splicing regulation in gastric cancer cells.
Exogenous H(2) S prevents the nuclear translocation of PDC-E1 and inhibits vascular smooth muscle cell proliferation in the diabetic state.
OGT regulated O-GlcNacylation promotes migration and invasion by activating IL-6/STAT3 signaling in NSCLC cells.
Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca(2+)](m)-PDP1-PDH-histone acetylation retrograde signaling.
Interferon functional analog activates antiviral Jak/Stat signaling through integrin in an arthropod.
Lactobacillus johnsonii L531 Alleviates the Damage Caused by Salmonella Typhimurium via Inhibiting TLR4, NF-κB, and NLRP3 Inflammasome Signaling Pathways.
Yixin-Fumai granules improve sick sinus syndrome in aging mice through Nrf-2/HO-1 pathway: A new target for sick sinus syndrome.
Lactobacillus casei relieves liver injury by regulating immunity and suppression of the enterogenic endotoxin-induced inflammatory response in rats cotreated with alcohol and iron.
Activation of the Hippocampal LXRβ Improves Sleep-Deprived Cognitive Impairment by Inhibiting Neuroinflammation.
Role of Intracellular Distribution of Feline and Bovine SAMHD1 Proteins in Lentiviral Restriction.
PML Suppresses Influenza Virus Replication by Promoting FBXW7 Expression.
The p38 MAPK/NF-κB pathway mediates GLT-1 up-regulation during cerebral ischemic preconditioning-induced brain ischemic tolerance in rats.
SGLT2 promotes pancreatic cancer progression by activating the Hippo signaling pathway via the hnRNPK-YAP1 axis.
Hsa_circ_0004296 inhibits metastasis of prostate cancer by interacting with EIF4A3 to prevent nuclear export of ETS1 mRNA.
Hexavalent chromium inhibits the formation of neutrophil extracellular traps and promotes the apoptosis of neutrophils via AMPK signaling pathway.
Harpagide alleviate neuronal apoptosis and blood-brain barrier leakage by inhibiting TLR4/MyD88/NF-κB signaling pathway in Angiotensin II-induced microglial activation in vitro.
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.
Over-methylation of Histone H3 Lysines Is a Common Molecular Change Among the Three Major Types of Soft-tissue Sarcoma in Patient-derived Xenograft (PDX) Mouse Models.
Discovery of Phenolic Glycoside from Hyssopus cuspidatus Attenuates LPS-Induced Inflammatory Responses by Inhibition of iNOS and COX-2 Expression through Suppression of NF-κB Activation.
LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome.
Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo.
Establishment of an Efficient Immortalization Strategy Using HMEJ-Based bTERT Insertion for Bovine Cells.
Scutellarin alleviates depression-like behaviors induced by LPS in mice partially through inhibition of astrocyte-mediated neuroinflammation.
Kaempferide enhances antioxidant capacity to promote osteogenesis through FoxO1/β-catenin signaling pathway.
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
BCL7C suppresses ovarian cancer growth by inactivating mutant p53.
BATF Regulates T Regulatory Cell Functional Specification and Fitness of Triglyceride Metabolism in Restraining Allergic Responses.
Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress-induced premature senescence.
Nucleolar and spindle‑associated protein 1 promotes non‑small cell lung cancer progression and serves as an effector of myocyte enhancer factor 2D.
Hepatocyte growth factor overexpression promotes osteoclastogenesis and exacerbates bone loss in CIA mice.
Bluetongue virus non-structural protein 3 (NS3) and NS4 coordinatively antagonize type Ⅰ interferon signaling by targeting STAT1.
Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy.
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.
New insights into Vitamin C function: Vitamin C induces JAK2 activation through its receptor-like transporter SVCT2.
A phase-separated nuclear GBPL circuit controls immunity in plants.
Mutual dependency between lncRNA LETN and protein NPM1 in controlling the nucleolar structure and functions sustaining cell proliferation.
Dioscin inhibits SCC15 cell proliferation via the RASSF1A/MST2/YAP axis.
Cellular FADD-like IL-1β-converting enzyme-inhibitory protein attenuates myocardial ischemia/reperfusion injury via suppressing apoptosis and autophagy simultaneously.
Bromodomain-containing proteins BRD1, BRD2, and BRD13 are core subunits of SWI/SNF complexes and vital for their genomic targeting in Arabidopsis.
Long noncoding RNA DGCR5 involves in tumorigenesis of esophageal squamous cell carcinoma via SRSF1-mediated alternative splicing of Mcl-1.
Cisplatin remodels the tumor immune microenvironment via the transcription factor EB in ovarian cancer.
Ischemic heart injury leads to HIF1-dependent differential splicing of CaMK2γ.
OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair.
Resveratrol and its derivative pterostilbene ameliorate intestine injury in intrauterine growth-retarded weanling piglets by modulating redox status and gut microbiota.
Caspase-1 inhibits IFN-β production via cleavage of cGAS during M. bovis infection.
Activation of microglial G‑protein-coupled receptor 30 protects neurons against excitotoxicity through NF-κB/MAPK pathways.
Identification of small molecules that mitigate vincristine-induced neurotoxicity while sensitizing leukemia cells to vincristine.
PP1 regulatory subunit NIPP1 regulates transcription of E2F1 target genes following DNA damage.
Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson's Disease Models.
Core Histones Are Constituents of the Perinuclear Theca of Murid Spermatozoa: An Assessment of Their Synthesis and Assembly during Spermiogenesis and Function after Gametic Fusion.
HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity.
Induction of mitochondrial apoptosis pathway mediated through caspase-8 and c-Jun N-terminal kinase by cadmium-activated Fas in rat cortical neurons.
Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans.
miR-937-5p targets SOX17 to modulate breast cancer cell cycle and cell proliferation through the Wnt signaling pathway.
Expression, Localization, and Function of the Nucleolar Protein BOP1 in Prostate Cancer Progression.
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis.
The transcriptional repressors VAL1 and VAL2 recruit PRC2 for genome-wide Polycomb silencing in Arabidopsis.
Protective Effects of Fisetin on Hepatic Ischemia-reperfusion Injury Through Alleviation of Apoptosis and Oxidative Stress.
Paeonol ameliorates CFA-induced inflammatory pain by inhibiting HMGB1/TLR4/NF-κB p65 pathway.
Panax notoginseng saponins promote endothelial progenitor cell angiogenesis via the Wnt/β-catenin pathway.
p53 induces ARTS to promote mitochondrial apoptosis.
HDAC9 in the Injury of Vascular Endothelial Cell Mediated by P38 MAPK Pathway.
ChREBP deficiency alleviates apoptosis by inhibiting TXNIP/oxidative stress in diabetic nephropathy.
Histone H3 lysine-trimethylation markers are decreased by recombinant methioninase and increased by methotrexate at concentrations which inhibit methionine-addicted osteosarcoma cell proliferation.
Stress-induced phosphoprotein 1 restrains spinal cord ischaemia-reperfusion injury by modulating NF-κB signalling.
NOD2-mediated P2Y(12) upregulation increases platelet activation and thrombosis in sepsis.
Pretreatment of Indobufen and Aspirin and their Combinations with Clopidogrel or Ticagrelor Alleviates Inflammasome Mediated Pyroptosis Via Inhibiting NF-κB/NLRP3 Pathway in Ischemic Stroke.
Pentagalloylglucose reduces AGE-induced inflammation by activating Nrf2/HO-1 and inhibiting the JAK2/STAT3 pathway in mesangial cells.
Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia.
Peony seed oil ameliorates neuroinflammation-mediated cognitive deficits by suppressing microglial activation through inhibition of NF-κB pathway in presenilin 1/2 conditional double knockout mice.
miR-140-3p enhanced the osteo/odontogenic differentiation of DPSCs via inhibiting KMT5B under hypoxia condition.
Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer.
Curcumin hinders PBDE-47-induced neutrophil extracellular traps release via Nrf2-associated ROS inhibition.
Protective effects of oridonin against cerebral ischemia/reperfusion injury by inhibiting the NLRP3 inflammasome activation.
Histone H2B ubiquitination mediated chromatin relaxation is essential for the induction of somatic cell reprogramming.
Glutaredoxin 1 protects neurons from oxygen-glucose deprivation/reoxygenation (OGD/R)-induced apoptosis and oxidative stress via the modulation of GSK-3β/Nrf2 signaling.
PLK2 protects retinal ganglion cells from oxidative stress by potentiating Nrf2 signaling via GSK-3β.
Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage.
CDDO-Im exerts antidepressant-like effects via the Nrf2/ARE pathway in a rat model of post-stroke depression.
Virtual screening identified natural Keap1-Nrf2 PPI inhibitor alleviates inflammatory osteoporosis through Nrf2-mir214-Traf3 axis.
Downregulation of miR-497-5p prevents liver ischemia-reperfusion injury in association with MED1/TIMP-2 axis and the NF-κB pathway.
GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis.
Programmed cell death 4 modulates lysosomal function by inhibiting TFEB translation.
Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis.
ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H(+)-ATPases is essential for brain development in humans and mice.
Impaired 26S Proteasome Assembly Precedes Neuronal Loss in Mutant UBQLN2 Rats.
5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats.
Glaucocalyxin A induces cell cycle arrest and apoptosis via inhibiting NF-κB/p65 signaling pathway in melanoma cells.
Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA-cGAS-STING Signaling Axis.
PD-L1 lncRNA splice isoform promotes lung adenocarcinoma progression via enhancing c-Myc activity.
S-allyl cysteine ameliorates heat stress-induced oxidative stress by activating Nrf2/HO-1 signaling pathway in BMECs.
Laminar Flow Protects Vascular Endothelial Tight Junctions and Barrier Function via Maintaining the Expression of Long Non-coding RNA MALAT1.
MiR-146a-5p Mimic Inhibits NLRP3 Inflammasome Downstream Inflammatory Factors and CLIC4 in Neonatal Necrotizing Enterocolitis.
miR-766-3p Targeting BCL9L Suppressed Tumorigenesis, Epithelial-Mesenchymal Transition, and Metastasis Through the β-Catenin Signaling Pathway in Osteosarcoma Cells.
LncRNA MALAT1 Affects Mycoplasma pneumoniae Pneumonia via NF-κB Regulation.
A Novel STAT3-Mediated GATA6 Pathway Contributes to tert-Butylhydroquinone- (tBHQ-) Protected TNFα-Activated Vascular Cell Adhesion Molecule 1 (VCAM-1) in Vascular Endothelium.
CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor.
MFP-FePt-GO Nanocomposites Promote Radiosensitivity of Non-Small Cell Lung Cancer Via Activating Mitochondrial-Mediated Apoptosis and Impairing DNA Damage Repair.
Sevoflurane Exposure Induces Neuronal Cell Parthanatos Initiated by DNA Damage in the Developing Brain via an Increase of Intracellular Reactive Oxygen Species.
RGFP966 Suppresses Tumor Growth and Migration Through Inhibition of EGFR Expression in Hepatocellular Carcinoma Cells in vitro.
Spinal N-Cadherin/CREB Signaling Contributes to Chronic Alcohol Consumption-Enhanced Postsurgical Pain.
lncRNA PCBP1-AS1 Aggravates the Progression of Hepatocellular Carcinoma via Regulating PCBP1/PRL-3/AKT Pathway.
NFE2L3 promotes malignant behavior and EMT of human hepatocellular carcinoma (HepG2) cells via Wnt/β‑catenin pathway.
Oxymatrine Inhibits Renal Cell Carcinoma Progression by Suppressing β-Catenin Expression.
Oxymatrine Attenuates Dopaminergic Neuronal Damage and Microglia-Mediated Neuroinflammation Through Cathepsin D-Dependent HMGB1/TLR4/NF-κB Pathway in Parkinson's Disease.
TRIM59 Protects Mice From Sepsis by Regulating Inflammation and Phagocytosis in Macrophages.
Poricoic acid A as a modulator of TPH-1 expression inhibits renal fibrosis via modulating protein stability of β-catenin and β-catenin-mediated transcription.
MicroRNA-34a Inhibition Alleviates Lung Injury in Cecal Ligation and Puncture Induced Septic Mice.
Extracellular Vesicles From Adipose Tissue-Derived Stem Cells Affect Notch-miR148a-3p Axis to Regulate Polarization of Macrophages and Alleviate Sepsis in Mice.
Antiviral Activity of Feline BCA2 Is Mainly Dependent on Its Interference With Proviral Transcription Rather Than Degradation of FIV Gag.
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.
N(6)-Methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2.
HMGB1 Inhibits HNF1A to Modulate Liver Fibrogenesis via p65/miR-146b Signaling.
Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis.
CLPTM1L induces estrogen receptor β signaling-mediated radioresistance in non-small cell lung cancer cells.
Camptothecin induced DDX5 degradation increased the camptothecin resistance of osteosarcoma.
FERMT1 promotes gastric cancer progression by activating the NF-κB pathway and predicts poor prognosis.
The interaction of lead exposure and CCM3 defect plays an important role in regulating angiogenesis through eNOS/NO pathway.
An NF-κB-driven lncRNA orchestrates colitis and circadian clock.
Zbtb20 deficiency causes cardiac contractile dysfunction in mice.
Emodin inhibiting neutrophil elastase-induced epithelial-mesenchymal transition through Notch1 signalling in alveolar epithelial cells.
Mechanisms by which electroacupuncture‑mediated histone acetylation mitigates bone loss in rats with ovariectomy‑induced osteoporosis.
Histone chaperone FACT represses retrotransposon MERVL and MERVL-derived cryptic promoters.
Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation.
Rosmarinic Acid Alleviates Inflammation, Apoptosis, and Oxidative Stress through Regulating miR-155-5p in a Mice Model of Parkinson's Disease.
Ochratoxin A induces reprogramming of glucose metabolism by switching energy metabolism from oxidative phosphorylation to glycolysis in human gastric epithelium GES-1 cells in vitro.
Echinacea polysaccharide alleviates LPS-induced lung injury via inhibiting inflammation, apoptosis and activation of the TLR4/NF-κB signal pathway.
The molecular basis of tight nuclear tethering and inactivation of cGAS.
Berberine protects against diabetic retinopathy by inhibiting cell apoptosis via deactivation of the NF‑κB signaling pathway.
Insulin Promotes Corneal Nerve Repair and Wound Healing in Type 1 Diabetic Mice by Enhancing Wnt/β-Catenin Signaling.
Interaction of BACH2 with FUS promotes malignant progression of glioma cells via the TSLNC8-miR-10b-5p-WWC3 pathway.
Active Peptide KF-8 from Rice Bran Attenuates Oxidative Stress in a Mouse Model of Aging Induced by d-Galactose.
Acetylharpagide Protects Mice from Staphylococcus Aureus-Induced Acute Lung Injury by Inhibiting NF-κB Signaling Pathway.
Targeting the NCOA3-SP1-TERT axis for tumor growth in hepatocellular carcinoma.
ARID1A-dependent permissive chromatin accessibility licenses estrogen-receptor signaling to regulate circadian rhythms genes in endometrial cancer.
PIGU promotes hepatocellular carcinoma progression through activating NF-κB pathway and increasing immune escape.
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Valproic acid targets HDAC1/2 and HDAC1/PTEN/Akt signalling to inhibit cell proliferation via the induction of autophagy in gastric cancer.
Functional analysis of MTF-1 and MT promoters and their transcriptional response to zinc (Zn) and copper (Cu) in yellow catfish Pelteobagrus fulvidraco.
Pseudorabies Virus Infection of Epithelial Cells Leads to Persistent but Aberrant Activation of the NF-κB Pathway, Inhibiting Hallmark NF-κB-Induced Proinflammatory Gene Expression.
The bromodomain containing protein BRD-9 orchestrates RAD51-RAD54 complex formation and regulates homologous recombination-mediated repair.
USP38 regulates the stemness and chemoresistance of human colorectal cancer via regulation of HDAC3.
Comprehensive identification of signaling pathways for idiopathic pulmonary arterial hypertension.
δ-Catenin regulates proliferation and apoptosis in renal cell carcinoma via promoting β-catenin nuclear localization and activating its downstream target genes.
Bclaf1 is a direct target of HIF-1 and critically regulates the stability of HIF-1α under hypoxia.
The Wnt/β-catenin/VASP positive feedback loop drives cell proliferation and migration in breast cancer.
NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.
TGFB1-induced autophagy affects the pattern of pancreatic cancer progression in distinct ways depending on SMAD4 status.
LYW-6, a novel cryptotanshinone derived STAT3 targeting inhibitor, suppresses colorectal cancer growth and metastasis.
Notch signal deficiency alleviates hypertrophic scar formation after wound healing through the inhibition of inflammation.
Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition.
ABA-responsive ABRE-BINDING FACTOR3 activates DAM3 expression to promote bud dormancy in Asian pear.
Inhibition of PIM1 attenuates the stem cell-like traits of breast cancer cells by promoting RUNX3 nuclear retention.
Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway.
The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor.
Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways.
Non-Esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway.
Deletion of newly described pro-survival molecule Pellino-1 increases oxidative stress, downregulates cIAP2/NF-κB cell survival pathway, reduces angiogenic response, and thereby aggravates tissue function in mouse ischemic models.
CaCBL1 Acts as a Positive Regulator in Pepper Response to Ralstonia solanacearum.
EHF promotes colorectal carcinoma progression by activating TGF-β1 transcription and canonical TGF-β signaling.
mTORC1-dependent TFEB nucleus translocation and pro-survival autophagy induced by zeolitic imidazolate framework-8.
(Pro)renin receptor contributes to hypoxia/reoxygenation-induced apoptosis and autophagy in myocardial cells via the beta-catenin signaling pathway.
Intracellular expression of arginine deiminase activates the mitochondrial apoptosis pathway by inhibiting cytosolic ferritin and inducing chromatin autophagy.
TCF7L2 rs290487 C allele aberrantly enhances hepatic gluconeogenesis through allele-specific changes in transcription and chromatin binding.
Loganin and catalpol exert cooperative ameliorating effects on podocyte apoptosis upon diabetic nephropathy by targeting AGEs-RAGE signaling.
Karyopherin α 2 promotes proliferation, migration and invasion through activating NF-κB/p65 signaling pathways in melanoma cells.
A Noncoding Regulatory RNAs Network Driven by Circ-CDYL Acts Specifically in the Early Stages Hepatocellular Carcinoma.
PCNA and GSK3β interact with each other to regulate H1299 lung adenocarcinoma cells apoptosis.
CHK2-FOXK axis promotes transcriptional control of autophagy programs.
MiR-146a down-regulates inflammatory response by targeting TLR3 and TRAF6 in Coxsackievirus B infection.
RNA binding protein FXR1-miR301a-3p axis contributes to p21WAF1 degradation in oral cancer.
GSPE alleviates renal fibrosis by inhibiting the activation of C3/ HMGB1/ TGF-β1 pathway.
Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt/Nrf2 signaling pathway.
Curcumin Protects Human Trophoblast HTR8/SVneo Cells from H(2)O(2)-Induced Oxidative Stress by Activating Nrf2 Signaling Pathway.
GDF15 induced by compressive force contributes to osteoclast differentiation in human periodontal ligament cells.
GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.
Protective effect of hydrogen sulfide on endothelial cells through Sirt1-FoxO1-mediated autophagy.
Novel poricoic acids attenuate renal fibrosis through regulating redox signalling and aryl hydrocarbon receptor activation.
Exogenous CGRP Regulates Apoptosis and Autophagy to Alleviate Traumatic Brain Injury Through Akt/mTOR Signalling Pathway.
Glutathione S-transferases P1-mediated interleukin-6 in tumor-associated macrophages augments drug-resistance in MCF-7 breast cancer.
Silibinin ameliorats H(2)O(2)-induced cell apoptosis and oxidative stress response by activating Nrf2 signaling in trophoblast cells.
lncMGPF is a novel positive regulator of muscle growth and regeneration.
Daphnetin ameliorates glucocorticoid-induced osteoporosis via activation of Wnt/GSK-3β/β-catenin signaling.
Effects of taraxasterol against ethanol and high-fat diet-induced liver injury by regulating TLR4/MyD88/NF-κB and Nrf2/HO-1 signaling pathways.
BRAHMA-interacting proteins BRIP1 and BRIP2 are core subunits of Arabidopsis SWI/SNF complexes.
TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents.
Hsa-miR-425-5p promotes tumor growth and metastasis by activating the CTNND1-mediated β-catenin pathway and EMT in colorectal cancer.
AKT/FOXO1 axis links cross-talking of endothelial cell and pericyte in TIE2-mutated venous malformations.
Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease.
1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells.
Computational repositioning of dimethyl fumarate for treating alcoholic liver disease.
Capsaicin suppressed activity of prostate cancer stem cells by inhibition of Wnt/β-catenin pathway.
WISP-2, an upregulated gene in hip cartilage from the DDH model rats, induces chondrocyte apoptosis through PPARγ in vitro.
C9orf72 associates with inactive Rag GTPases and regulates mTORC1-mediated autophagosomal and lysosomal biogenesis.
PGN and LTA from Staphylococcus aureus Induced Inflammation and Decreased Lactation through Regulating DNA Methylation and Histone H3 Acetylation in Bovine Mammary Epithelial Cells.
Interaction between p53 and Ras signaling controls cisplatin resistance via HDAC4- and HIF-1α-mediated regulation of apoptosis and autophagy.
Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation.
Identification of RE1-Silencing Transcription Factor as a Promoter of Metastasis in Pancreatic Cancer.
Role of Antioxidants in the Protection from Aging-Related Diseases.
Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3K/AKT and Nrf2 Pathways.
Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR.
Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.
Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway.
Liraglutide Improves Non-Alcoholic Fatty Liver Disease In Diabetic Mice By Modulating Inflammatory Signaling Pathways.
TFEB Probably Involved in Midazolam-Disturbed Lysosomal Homeostasis and Its Induced β-Amyloid Accumulation.
β-elemene inhibits radiation and hypoxia-induced macrophages infiltration via Prx-1/NF-κB/HIF-1α signaling pathway.
Dl-3-n-Butylphthalide Exerts Dopaminergic Neuroprotection Through Inhibition of Neuroinflammation.
Propofol Alleviates DNA Damage Induced by Oxygen Glucose Deprivation and Reperfusion via FoxO1 Nuclear Translocation in H9c2 Cells.
The Therapeutic Effects of Treadmill Exercise on Osteoarthritis in Rats by Inhibiting the HDAC3/NF-KappaB Pathway in vivo and in vitro.
CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation.
Bavachinin exhibits antitumor activity against non‑small cell lung cancer by targeting PPARγ.
Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay.
Sirtuin 7 promotes 45S pre-rRNA cleavage at site 2 and determines the processing pathway.
MD-2 Homologue Recognizes the White Spot Syndrome Virus Lipid Component and Induces Antiviral Molecule Expression in Shrimp.
Naringin mitigates myocardial strain and the inflammatory response in sepsis-induced myocardial dysfunction through regulation of PI3K/AKT/NF-κB pathway.
MiR-26a promotes fracture healing of nonunion rats possibly by targeting SOSTDC1 and further activating Wnt/β-catenin signaling pathway.
Chrysophanol attenuates airway inflammation and remodeling through nuclear factor-kappa B signaling pathway in asthma.
Wnt7a, frequently silenced by CpG methylation, inhibits tumor growth and metastasis via suppressing epithelial-mesenchymal transition in gastric cancer.
CyclinD1 inhibits dicer and crucial miRNA expression by chromatin modification to promote the progression of intrahepatic cholangiocarcinoma.
The therapeutic effect of verapamil in lipopolysaccharide-induced acute lung injury.
NEDD4 protects vascular endothelial cells against Angiotensin II-induced cell death via enhancement of XPO1-mediated nuclear export.
Trans-cinnamaldehyde improves neuroinflammation-mediated NMDA receptor dysfunction and memory deficits through blocking NF-κB pathway in presenilin1/2 conditional double knockout mice.
SIRT4 enhances the sensitivity of ER-positive breast cancer to tamoxifen by inhibiting the IL-6/STAT3 signal pathway.
Ginkgolide B and bilobalide promote the growth and increase β-catenin expression in hair follicle dermal papilla cells of American minks.
PI3K p110α inhibition sensitizes cervical cancer cells with aberrant PI3K signaling activation to PARP inhibitor BMN673.
Clematichinenoside Facilitates Recovery of Neurological and Motor Function in Rats after Cerebral Ischemic Injury through Inhibiting Notch/NF-κB Pathway.
LncRNA HOTAIRM1 promotes osteogenesis by controlling JNK/AP-1 signalling-mediated RUNX2 expression.
Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus.
ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex.
FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival.
TFEB Mediates Immune Evasion and Resistance to mTOR Inhibition of Renal Cell Carcinoma via Induction of PD-L1.
Micro-RNA-27a/b negatively regulates hepatic gluconeogenesis by targeting FOXO1.
CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression.
HepaCAM Regulates Warburg Effect of Renal Cell Carcinoma via HIF-1α/NF-κB Signaling Pathway.
Nonmuscle Myosin Heavy Chain IIA Recognizes Sialic Acids on Sialylated RNA Viruses To Suppress Proinflammatory Responses via the DAP12-Syk Pathway.
Abnormal expression of TBX4 during anorectal development in rat embryos with ethylenethiourea-induced anorectal malformations.
Stella protein facilitates DNA demethylation by disrupting the chromatin association of the RING finger-type E3 ubiquitin ligase UHRF1.
Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway.
Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation.
Diminished membrane recruitment of Akt is instrumental in alcohol-associated osteopenia via the PTEN/Akt/GSK-3β/β-catenin axis.
Blockade of YAP alleviates hepatic fibrosis through accelerating apoptosis and reversion of activated hepatic stellate cells.
The selective HDAC6 inhibitor Nexturastat A induces apoptosis, overcomes drug resistance and inhibits tumor growth in multiple myeloma.
Suppression of puerarin on polymethylmethacrylate-induced lesion of peri-implant by inhibiting NF-κB activation in vitro and in vivo.
MicroRNA-126 Regulates Angiogenesis and Neurogenesis in a Mouse Model of Focal Cerebral Ischemia.
Tempol alleviates chronic intermittent hypoxia-induced pancreatic injury through repressing inflammation and apoptosis.
Epigenetic suppression of liver X receptor β in anterior cingulate cortex by HDAC5 drives CFA-induced chronic inflammatory pain.
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
LXA4 ameliorates cerebrovascular endothelial dysfunction by reducing acute inflammation after subarachnoid hemorrhage in rats.
The perforatorium and postacrosomal sheath of rat spermatozoa share common developmental origins and protein constituents†.
Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors.
A novel, highly-water-soluble apigenin derivative provides neuroprotection following ischemia in male rats by regulating the ERK/Nrf2/HO-1 pathway.
In the human sperm nucleus, nucleosomes form spatially restricted domains consistent with programmed nucleosome positioning.
OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice.
Bclaf1 critically regulates the type I interferon response and is degraded by alphaherpesvirus US3.
HSPA12A Is a Novel Player in Nonalcoholic Steatohepatitis via Promoting Nuclear PKM2-Mediated M1 Macrophage Polarization.
Activation of brain endothelium by Escherichia coli K1 virulence factor cglD promotes polymorphonuclear leukocyte transendothelial migration.
CP-25 combined with MTX/ LEF ameliorates the progression of adjuvant-induced arthritis by the inhibition on GRK2 translocation.
Milk fat globule-epidermal growth factor 8 (MFG-E8) attenuates sepsis-induced acute kidney injury by inhibiting NF-κB signaling pathway1.
m(6)A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner.
Protective effects of a neurokinin 1 receptor antagonist on airway epithelial mitochondria dysfunction in asthmatic mice via Nrf2/HO-1 activation.
AZD9291 inactivates the PRC2 complex to mediate tumor growth inhibition.
Peroxisome proliferator-activated receptor gamma participates in the acquisition of brain ischemic tolerance induced by ischemic preconditioning via glial glutamate transporter 1 in vivo and in vitro.
Endogenous ET-1 promotes ANP secretion through activation of COX2-L-PGDS-PPARγ signaling in hypoxic beating rat atria.
Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer.
Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis.
Bilirubin alleviates alum-induced peritonitis through inactivation of NLRP3 inflammasome.
TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells.
Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure.
Calcium-sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor-β signaling to promote breast cancer metastasis.
PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis.
KMT2D deficiency enhances the anti-cancer activity of L48H37 in pancreatic ductal adenocarcinoma.
HO-1 reduces heat stress-induced apoptosis in bovine granulosa cells by suppressing oxidative stress.
Regulation of position effect variegation at pericentric heterochromatin by Drosophila Keap1-Nrf2 xenobiotic response factors.
Knockdown of cathepsin D protects dopaminergic neurons against neuroinflammation-mediated neurotoxicity through inhibition of NF-κB signalling pathway in Parkinson's disease model.
SRT1720 retards renal fibrosis via inhibition of HIF1A/GLUT1 in diabetic nephropathy.
5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress.
Stabilized Peptide HDAC Inhibitors Derived from HDAC1 Substrate H3K56 for the Treatment of Cancer Stem-Like Cells In Vivo.
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF-κB signaling pathway in a mouse model of Parkinson's disease.
miR-203 Inhibits Alcohol-Induced Hepatic Steatosis by Targeting Lipin1.
Aryl hydrocarbon receptor activated by benzo (a) pyrene promotes SMARCA6 expression in NSCLC.
Adipocytes fuel gastric cancer omental metastasis via PITPNC1-mediated fatty acid metabolic reprogramming.
Flavonoid-Rich Ethanol Extract from the Leaves of Diospyros kaki Attenuates D-Galactose-Induced Oxidative Stress and Neuroinflammation-Mediated Brain Aging in Mice.
3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation.
Lithium chloride inhibits cell survival, overcomes drug resistance, and triggers apoptosis in multiple myeloma via activation of the Wnt/β-catenin pathway.
Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.
Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury.
Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors.
XPO1-mediated nuclear export of RNF146 protects from angiotensin II-induced endothelial cellular injury.
REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis.
Isopsoralen Enhanced Osteogenesis by Targeting AhR/ERα.
BRMS1L suppresses ovarian cancer metastasis via inhibition of the β-catenin-wnt pathway.
Regulation of osteogenesis by micro/nano hierarchical titanium surfaces through a Rock-Wnt5a feedback loop.
Inhibition of microRNA-143-3p attenuates myocardial hypertrophy by inhibiting inflammatory response.
Citrus Tangeretin Improves Skeletal Muscle Mitochondrial Biogenesis via Activating the AMPK-PGC1-α Pathway In Vitro and In Vivo: A Possible Mechanism for Its Beneficial Effect on Physical Performance.
Small molecules capable of activating DNA methylation-repressed genes targeted by the p38 mitogen-activated protein kinase pathway.
Mitotic Phosphorylation of SENP3 Regulates DeSUMOylation of Chromosome-Associated Proteins and Chromosome Stability.
Sphingosine-1-phosphate ameliorates the cardiac hypertrophic response through inhibiting the activity of histone deacetylase-2.
Key Role of TFEB Nucleus Translocation for Silver Nanoparticle-Induced Cytoprotective Autophagy.
The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1.
JMJD3 is involved in neutrophil membrane proteinase 3 overexpression during the hyperinflammatory response in early sepsis.
Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.
Integrin αvβ3-associated DAAM1 is essential for collagen-induced invadopodia extension and cell haptotaxis in breast cancer cells.
The histone methyltransferase SETD2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice.
The Role of the RhoA/ROCK Signaling Pathway in Mechanical Strain-Induced Scleral Myofibroblast Differentiation.
Ubiquitin-Specific Protease USP6 Regulates the Stability of the c-Jun Protein.
6-Hydroxydopamine induces autophagic flux dysfunction by impairing transcription factor EB activation and lysosomal function in dopaminergic neurons and SH-SY5Y cells.
CDK5-mediated phosphorylation of Sirt2 contributes to depressive-like behavior induced by social defeat stress.
Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway.
Yes-Associated Protein Promotes Angiogenesis via Signal Transducer and Activator of Transcription 3 in Endothelial Cells.
Modulation of autophagy in the protective effect of resveratrol on PM2.5-induced pulmonary oxidative injury in mice.
Tempol relieves lung injury in a rat model of chronic intermittent hypoxia via suppression of inflammation and oxidative stress.
DNase-1 Treatment Exerts Protective Effects in a Rat Model of Intestinal Ischemia-Reperfusion Injury.
Anticancer effect of histone deacetylase inhibitor scriptaid as a single agent for hepatocellular carcinoma.
Thymol alleviates lipopolysaccharide-stimulated inflammatory response via downregulation of RhoA-mediated NF-κB signalling pathway in human peritoneal mesothelial cells.
Role of Peroxiredoxin 2 in the Protection Against Ferrous Sulfate-Induced Oxidative and Inflammatory Injury in PC12 Cells.
27-Hydroxycholesterol Inhibits Sterol Regulatory Element-Binding Protein 1 Activation and Hepatic Lipid Accumulation in Mice.
Anti-Proliferative Activity of HPOB against Multiple Myeloma Cells via p21 Transcriptional Activation.
Neurochondrin interacts with the SMN protein suggesting a novel mechanism for spinal muscular atrophy pathology.
Epstein-Barr Virus miR-BART6-3p Inhibits the RIG-I Pathway.
EGFRwt/vIII-PKM2-β-catenin cascade affects proliferation and chemo-sensitivity in head and neck squamous cell carcinoma.
trans-Cinnamaldehyde Inhibits Microglial Activation and Improves Neuronal Survival against Neuroinflammation in BV2 Microglial Cells with Lipopolysaccharide Stimulation.
Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis.
TSPAN31 is a critical regulator on transduction of survival and apoptotic signals in hepatocellular carcinoma cells.
MicroRNA-27b inhibition promotes Nrf2/ARE pathway activation and alleviates intracerebral hemorrhage-induced brain injury.
An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.
Triptolide induces DNA breaks, activates caspase-3-dependent apoptosis and sensitizes B-cell lymphoma to poly(ADP-ribose) polymerase 1 and phosphoinositide 3-kinase inhibitors.
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathway.
Involvement of aberrantly activated HOTAIR/EZH2/miR-193a feedback loop in progression of prostate cancer.
YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63-GPX2 Axis and ROS Accumulation.
Shp2 promotes liver cancer stem cell expansion by augmenting β-catenin signaling and predicts chemotherapeutic response of patients.
Hypoxia induces oncogene yes-associated protein 1 nuclear translocation to promote pancreatic ductal adenocarcinoma invasion via epithelial-mesenchymal transition.
Early-Life Social Isolation-Induced Depressive-Like Behavior in Rats Results in Microglial Activation and Neuronal Histone Methylation that Are Mitigated by Minocycline.
Aspirin suppresses the abnormal lipid metabolism in liver cancer cells via disrupting an NFκB-ACSL1 signaling.
miR-181a-5p, an inducer of Wnt-signaling, facilitates cell proliferation in acute lymphoblastic leukemia.
BTP2, a Store-Operated Calcium Channel Inhibitor, Attenuates Lung Ischemia-Reperfusion Injury in Rats.
Long noncoding RNA CRNDE stabilized by hnRNPUL2 accelerates cell proliferation and migration in colorectal carcinoma via activating Ras/MAPK signaling pathways.
RACK1 promotes lung cancer cell growth via an MCM7/RACK1/ Akt signaling complex.
Quinocetone induces mitochondrial apoptosis in HepG2 cells through ROS-dependent promotion of VDAC1 oligomerization and suppression of Wnt1/β-catenin signaling pathway.
CDK5-mediated phosphorylation of XBP1s contributes to its nuclear translocation and activation in MPP(+)-induced Parkinson's disease model.
Dicer promotes tumorigenesis by translocating to nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells.
Rabphilin 3A: A novel target for the treatment of levodopa-induced dyskinesias.
Kaiso protects human umbilical vein endothelial cells against apoptosis by differentially regulating the expression of B-cell CLL/lymphoma 2 family members.
Tert-butylhydroquinone protects PC12 cells against ferrous sulfate-induced oxidative and inflammatory injury via the Nrf2/ARE pathway.
Targeting NF-kB signaling with polymeric hybrid micelles that co-deliver siRNA and dexamethasone for arthritis therapy.
Transcription factors regulate GPR91-mediated expression of VEGF in hypoxia-induced retinopathy.
Loss of Polycomb Group Protein Pcgf1 Severely Compromises Proper Differentiation of Embryonic Stem Cells.
Daphnetin Protects against Cerebral Ischemia/Reperfusion Injury in Mice via Inhibition of TLR4/NF-κB Signaling Pathway.
Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.
Compositional Analysis of Asymmetric and Symmetric Dimethylated H3R2 Using Liquid Chromatography-Tandem Mass Spectrometry-Based Targeted Proteomics.
Anticancer effect of SZC015 on lung cancer cells through ROS-dependent apoptosis and autophagy induction mechanisms in vitro.
Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents.
S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
TGF-β1 activates the canonical NF-κB signaling to promote cell survival and proliferation in dystrophic muscle fibroblasts in vitro.
Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus.
New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.
HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis.
Downregulation of HP1α suppresses proliferation of cholangiocarcinoma by restoring SFRP1 expression.
Downregulation of vimentin expression increased drug resistance in ovarian cancer cells.
Downregulation of ACE2/Ang-(1-7)/Mas axis promotes breast cancer metastasis by enhancing store-operated calcium entry.
SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
IL-17 intensifies IFN-γ-induced NOS2 upregulation in RAW 264.7 cells by further activating STAT1 and NF-κB.
Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells.
The HIF/PHF8/AR axis promotes prostate cancer progression.
Genetic variants in microRNAs predict non-small cell lung cancer prognosis in Chinese female population in a prospective cohort study.
Molecular similarity guided optimization of novel Nrf2 activators with 1,2,4-oxadiazole core.
Early ketamine exposure results in cardiac enlargement and heart dysfunction in Xenopus embryos.
FUS Interacts with HSP60 to Promote Mitochondrial Damage.
The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer.
The Steroid Hormone 20-Hydroxyecdysone Up-regulates Ste-20 Family Serine/Threonine Kinase Hippo to Induce Programmed Cell Death.
Mulberry fruit prevents LPS-induced NF-κB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice.
Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.
Scutellarein inhibits cancer cell metastasis in vitro and attenuates the development of fibrosarcoma in vivo.
SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells.
O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.
Histone methyltransferase G9a and H3K9 dimethylation inhibit the self-renewal of glioma cancer stem cells.
Role of NSD1 in H2O2-induced GSTM3 suppression.
Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability.
CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells.
The oncoprotein HBXIP uses two pathways to up-regulate S100A4 in promotion of growth and migration of breast cancer cells.
Li H, Zhang S, Feng C, Cheng F, Han Y, Wang M, Zhou S, Shao W, Chen W, Chen J, Liu K, Zhang Y, Wang J
International journal of biological sciences 2026;22(4):1834-1851
International journal of biological sciences 2026;22(4):1834-1851
Schisandrin B Targets PXR to Enhance Bile Acid Metabolism and Alleviate ANIT-Induced Cholestatic Liver Injury via Dual Pathways.
Zhang Y, Lan H, Yu X, Zhuo L, Zhao B, Liu F, An L, Zhang F, Liu Z, Wang C
International journal of biological sciences 2026;22(1):387-409
International journal of biological sciences 2026;22(1):387-409
EP300/YAP1-SERPINE1 Signaling Regulates Ductular Reaction and Liver Fibrosis in Biliary Atresia.
Zhu Z, Lu C, Lv X, Lu Y, Zhu W, Zhu Y, Zhang R, Ding Z, Xie H, Tang W
Cellular and molecular gastroenterology and hepatology 2026;20(1):101640
Cellular and molecular gastroenterology and hepatology 2026;20(1):101640
Xiaoyao San alleviates emotional distress - induced TNBC growth through augmenting intratumoral CD8(+)T cell infiltration mediated by Rela/NF-kB-Cxcl9 axis.
Liang Y, Wu Y, Chen J, Shi H, Li Z, Zeng J, Huang J, Zuo Q, Ye L, Song X, Dai Y, Bai Y, Chen Q
Frontiers in immunology 2026;17:1762492
Frontiers in immunology 2026;17:1762492
A putative prognostic model for lung adenocarcinoma based on crotonylation-related genes by bioinformatics and experimental verification.
Wang W, Cui B, Li H, Zhen Z, Song X, Yuan X, Cui Q, Yuan Q, Liu Y
Frontiers in cell and developmental biology 2026;14:1639773
Frontiers in cell and developmental biology 2026;14:1639773
Characteristics of Exosomes and Microbiota in the Decidua of Patients With Early Pregnancy Loss and Their Impact on Trophoblast Cells.
He F, Chen L, Lou J, Guo Y, Fan S, Yan T, Zhang Y
Molecular reproduction and development 2026 May;93(5):e70104
Molecular reproduction and development 2026 May;93(5):e70104
Dual function of DOT1L suppresses tumor cell-intrinsic immunogenicity in hepatocellular carcinoma.
Xu S, Gong R, Liu S, Wang J, Shen Y, Peng C, Feng Q, Luo M, Lan F, Fan J, Cai J, Lan X
Oncogene 2026 May;45(16):1484-1500
Oncogene 2026 May;45(16):1484-1500
Identification of STMN1 as a lactylation‑related driver of lung cancer progression using Mendelian randomization.
Cai Y, Zhong Y, Wang H, Zhu S, Huang F, Zhang Q, Hu S
Molecular medicine reports 2026 May;33(5)
Molecular medicine reports 2026 May;33(5)
miR-221 Mediates the Regulation of Phospholamban Expression and Cardiac Contractility by ZBTB20.
Ren QX, Liu YJ, Wang P, Song X, Zhao Q, Cao YN, Hui RT, Yang HT, Zhu Y, Wei CC, Ren AJ, Zhang WJ
Acta physiologica (Oxford, England) 2026 May;242(5):e70217
Acta physiologica (Oxford, England) 2026 May;242(5):e70217
HnRNP C binding to inverted Alu elements protects the transcriptome from pre-mRNA circularization.
Marini A, Pitolli C, Ciccone S, Pieraccioli M, Robil N, Naro C, Palluzzi F, Giansanti M, Tamburrini G, Giacò L, de la Grange P, Nazio F, Bielli P, Sette C, Pagliarini V
Science advances 2026 May;12(18):eaea2351
Science advances 2026 May;12(18):eaea2351
NUP62 promotes breast cancer progression and inhibits ferroptosis by stabilizing NRF2 in a KEAP1-dependent way.
Qiu Z, Lin Y, Chen S, Cao W, Yang J, Li R, Chen Y, Yao X, Fu S, Jin N
iScience 2026 May 15;29(5):115484
iScience 2026 May 15;29(5):115484
Hypoxia-driven phase separation of the PABP1/eIF4B complex forms stress granules and activates ChaC2 translation to promote polyunsaturated lipids-supported peritoneal metastasis in gastric cancer.
Lin Z, Gao Y, Zhang Q, Yang S, Chen Y, Ding H, Peng W, Zhang X, Nurzat Y, Hu J, Liao W, Xiong B, Xiao M, Zhang X
Cancer letters 2026 May 1;645:218392
Cancer letters 2026 May 1;645:218392
m6A deficiency induces dopaminergic neurodegeneration and progressive parkinsonism through a pathogenic loop with mitochondria.
Liu S, Ren Q, Mo G, Li Z, Huang H, Zhou Y, Miao Z, Cao X, Wu B, Xiao Z, Yu S, Wu G, Xia L, Cui J, Mo J, Li Y, Xia L, Shen J, Xiao S
The Journal of clinical investigation 2026 May 1;136(9)
The Journal of clinical investigation 2026 May 1;136(9)
AARS1-mediated lactylation of H3K18 and STAT1 promotes ferroptosis in diabetic nephropathy.
Hong J, Xu H, Yu L, Yu Z, Chen X, Meng Z, Zhu J, Li J, Zhu M
Cell death and differentiation 2026 Mar;33(3):589-604
Cell death and differentiation 2026 Mar;33(3):589-604
Restricting Synaptotagmin-3 Internalization Mitigates Cerebral Ischemia/Reperfusion Injury by Curtailed Neuronal Apoptosis and Microglial Re-Programming.
Xu H, Mi H, Cheng R, Gui T, Hu F, Yang Y, Cheng J, Xue Q
CNS neuroscience & therapeutics 2026 Mar;32(3):e70815
CNS neuroscience & therapeutics 2026 Mar;32(3):e70815
Nanog mediated control of TBX3-GATA6 circuitry in primitive endoderm differentiation of mESCs.
Wu H, Ye Y, Dai H, Chen P, Yang T, Li Z, Li L, Parsania C, Ding J, Zhang M, Zuo E, Schmitz U, Chen X, Zhu Z, Zhang W
EMBO reports 2026 Mar;27(5):1209-1227
EMBO reports 2026 Mar;27(5):1209-1227
Dextrorotatory kynurenine suppresses acute rejection through inhibiting M1 macrophage-mediated inflammation.
Zhao Y, Wu J, Li Y, Cao Y, Zhu T, Guo Y, Yang C, Zhu D
EMBO molecular medicine 2026 Mar;18(3):979-1008
EMBO molecular medicine 2026 Mar;18(3):979-1008
Multi-omics mapping identifies CYBA-mediated mitochondrial dysfunction driving macrophage polarization and ferroptosis via Nrf2 pathway in atherosclerosis.
Dong C, Shen R, Pan C, Zhang J, Yu K, Zeng Q
APL bioengineering 2026 Mar;10(1):016107
APL bioengineering 2026 Mar;10(1):016107
NPM3 functions as a lactyltransferase to promote necroptosis in male diabetic cardiomyopathy mice models via FASN transcription modulation.
Xu H, Jiang X, Wang F, Meng F, Liu Y, Huang J, Li J, Zhu M
Nature communications 2026 Mar 9;17(1)
Nature communications 2026 Mar 9;17(1)
Intracellular complement Factor H promotes tumor progression through modulation of cell cycle and actin cytoskeleton.
Rezola Artero M, Minery A, Revel M, Armento A, Jarboui MA, Boudhabhay I, de Castro Deus M, Zarantonello A, Fleury E, Segarra L, Redissi A, Merle NS, Dragon-Durey MA, Monnot C, Sautes-Fridman C, Dimitrov JD, Fridman WH, Ueffing M, Roumenina LT
Communications biology 2026 Mar 5;9(1)
Communications biology 2026 Mar 5;9(1)
TFAP2A regulates SGPP2 transcription to promote lipid accumulation and activate the Wnt/β-catenin signaling pathway to promote malignant progression in lung adenocarcinoma.
Li Q, Li J, Zhang C, Deng Y, Yang B, Ma L, Liu Y, Wang C, Xu L, Mei J
Journal of translational medicine 2026 Mar 4;24(1)
Journal of translational medicine 2026 Mar 4;24(1)
EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS-STING Pathway.
Huo L, Wu C, Li X, Ma C, Huang J, Chen Z, He W, Tao T, Zhang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 30;:e22826
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 30;:e22826
Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated mitophagy.
Fang Y, Deng M, Huang K, Song H, Chu Y, Wei H, Chen D, Yang Y, Han C, Yuan H
Cell communication and signaling : CCS 2026 Mar 28;24(1)
Cell communication and signaling : CCS 2026 Mar 28;24(1)
Chemotherapy-induced senescent nasopharyngeal carcinoma cells suppress NK cell-mediated antitumor immunity by upregulating EBI3 via mtDNA-cGAS-STING pathway.
Liang L, Liu S, Li Y, Zeng F, He Q, Wang Z, Deng J, Zhou Y
Cell communication and signaling : CCS 2026 Mar 28;24(1)
Cell communication and signaling : CCS 2026 Mar 28;24(1)
Pharmaco-genomic characterization of pancreatic and biliary tract cancer tumoroids for drug response.
Fang K, Zhang W, Zhao Q, Hong Y, Wang R, Yang B, Zhao Y, Shi Y, Zhou B, Ding J, Fang Y, Chen Y
iScience 2026 Mar 20;29(3):115062
iScience 2026 Mar 20;29(3):115062
VISTA promotes ovarian cancer progression through activation of NF-κB pathway and tumor microenvironment reprogramming.
Liu S, Zhou Q, Ji F, Zhu T, Ding B, Xu J, Zhang T, Lin H, Shen Y
Journal of ovarian research 2026 Mar 20;19(1)
Journal of ovarian research 2026 Mar 20;19(1)
H3K9me2 is a determinant for the mitosis-to-meiosis transition in female germ cells.
Hu Y, Zhou H, Shi L, Liu K, Meng X, Guo X, Shan L, Hu F, Liu Y, Zhang T, Zhou Y
Cell death & disease 2026 Mar 2;17(1)
Cell death & disease 2026 Mar 2;17(1)
H3K27me3-mediated chromatin remodeling governs salt tolerance in cotton via Na(+)/K(+) homeostasis modulation.
Liu W, Zhang Z, Du Q, Li J, Yang L, Ren Z, Guo J, Zhu W, Ma Z, Zhou Y, Li W
Journal of advanced research 2026 Mar 17;
Journal of advanced research 2026 Mar 17;
CD93-targeted resveratrol-loaded PLGA nanoparticles remodel CD8⁺ T cell metabolism through AIF-mediated oxidative phosphorylation to overcome lung cancer immunotherapy resistance.
Jiang Z, Li Y
Journal of nanobiotechnology 2026 Mar 14;24(1)
Journal of nanobiotechnology 2026 Mar 14;24(1)
CXCL12 Promotes Peripheral Nerve Injury Repair by Inhibiting the Ferroptosis-Inflammation Axis via the ERK/Nrf2 Pathway.
Yuan Y, Jiang Y, Du S, Yuan G, Yang Z, Wang P
Inflammation 2026 Mar 12;49(1)
Inflammation 2026 Mar 12;49(1)
Synergistic Anti-Tumor Activity of LRPPRC Inhibition and Dasatinib Through Dual Oxidative Phosphorylation Disruption.
Chen J, Gao L, Liang Y, Zhou W, Wang Y, Wang X, Fang X, Shao X
Pharmaceuticals (Basel, Switzerland) 2026 Mar 12;19(3)
Pharmaceuticals (Basel, Switzerland) 2026 Mar 12;19(3)
S100A11 regulates microglial inflammatory response in neuropathic pain via H3K27ac-TFEB-mitochondrial autophagy axis.
Zheng H, Tian S, Wu L, Jia G, Xiao Y, Yu X, Zuo Q, Zhou R, Min J, Wu Q, Xie H, Luo Q, Wu W
The journal of headache and pain 2026 Mar 11;27(1)
The journal of headache and pain 2026 Mar 11;27(1)
ACSS2-mediated lysine crotonylation attenuates senescence and enhances the therapeutic efficacy of adipose-derived stem cells in inflammatory bowel disease.
Yuan M, Li S, Chen S, Zhu M, Yu R, Huang J, Liang G, Zhang C, He X, Lan P, Wu X
Cell regeneration (London, England) 2026 Mar 1;15(1)
Cell regeneration (London, England) 2026 Mar 1;15(1)
Membrane-camouflaged nanoparticle alleviates intervertebral disc degeneration via oxidative stress suppression and autophagy activation.
Niu Z, Fan Y, Chen J, Ji L, Tong Y, Yao L, Ding S, Xu H, Chen J, Zhang Q, Zhao C, Chen J, Bi Q, Xia C
Materials today. Bio 2026 Jun;38:103038
Materials today. Bio 2026 Jun;38:103038
Prostaglandin F2α impairs skin regeneration via FP receptor-mediated oxidative stress overriding autophagic protection in fibroblasts.
Wen Z, Guo Y, Bai R, Liu W, Liang B, Dong C, Zhang Y, Song Y, Wang T, Wang Z, Du J, Ma X, Ding J, Yu Z
Pathology, research and practice 2026 Jun;282:156467
Pathology, research and practice 2026 Jun;282:156467
Sijunzi decoction alleviates cancer cachexia myatrophy by suppressing M2 polarization of tumor-associated macrophages via the MCT1/lactate/H3K18 lactylation pathway.
Nie D, Zhang Y, Jia R, Fang Z, Zhu G, Xu B, Guo T, Zhang H
Journal of ethnopharmacology 2026 Jun 12;364:121500
Journal of ethnopharmacology 2026 Jun 12;364:121500
HnRNP H1 binds to nucleocapsid protein and potential guanine-quadruplex site of viral RNA to promote PRRSV-2 proliferation.
Zhang L, Jing H, Song Y, Zhao P, Zhang Z, Duan E, Liu J, Li H
Research in veterinary science 2026 Jul;206:106188
Research in veterinary science 2026 Jul;206:106188
Metformin attenuates colitis via blocking STAT3 acetylation by reducing acetyl-CoA production.
Li X, Xiang Z, Wang X, He H, Xu M, Tan C, Wu X, Zhang J, Dong W
Journal of advanced research 2026 Jan;79:393-407
Journal of advanced research 2026 Jan;79:393-407
Transcriptional condensates enrich phosphorylated PRMT2 to stimulate H3R8me2a deposition and hypoxic response in glioblastoma.
Dong F, Cheng X, Wan J, Li Q, Du W, Li W, Sun X, Wu X
Science China. Life sciences 2026 Jan;69(1):224-238
Science China. Life sciences 2026 Jan;69(1):224-238
An ATP-gated molecular switch orchestrates human mRNA export.
Hohmann U, Graf M, Tirián L, Pacheco-Fiallos B, Schellhaas U, Fin L, Handler D, Phillips AW, Riabov-Bassat D, Faraway R, Pühringer T, Szalay MF, Roitinger E, Brennecke J, Plaschka C
Nature 2026 Jan;649(8098):1042-1050
Nature 2026 Jan;649(8098):1042-1050
S-phase PARylation of microprotein RSMC enhances the function of Sororin in sister chromatid cohesion.
Jiang M, Zhang J, He J, Miao Y, Wang L, Zhong H, Gong Y, Li Z, Du LL, Xu X, Chen C, Ydyrys A, Xia Y, Cao Q, Lou H, Hou W
The EMBO journal 2026 Jan;45(1):278-309
The EMBO journal 2026 Jan;45(1):278-309
Complement C3a Suppresses Spinal Cord Neural Stem Cell Activation by Inhibiting UCHL1 via the NF-κB p65/Nrf2 Pathway.
Ding L, Li X, Guo Y, Zhou FQ, Deng DYB
Neuroscience bulletin 2026 Jan;42(1):153-174
Neuroscience bulletin 2026 Jan;42(1):153-174
Transdermal delivery of salvianolic acid B using thermosensitive hydrogel for the treatment of skin photoaging.
Wu L, Tao Y, Xu Y, Liang Z, Zhao Y
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):113-127
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):113-127
A bioactive protein from Dioscorea polystachya residue alleviates hydrocortisone-induced erectile dysfunction in rats via TXNIP/NLRP3 pathway inhibition.
Yu S, Zhang Y, Xi J, Feng J, Xie T, Pan D, Zhao D, Ren J, Dong Z, Liu M, Wang S
International journal of biological macromolecules 2026 Jan;335(Pt 1):149351
International journal of biological macromolecules 2026 Jan;335(Pt 1):149351
ABCC10-mediated cGAMP efflux drives cancer cell radiotherapy resistance.
Zhang Z, Gao J, Liao X, Zhang Z, Cao X, Gong Y, Chen W, Zhang L, Tsai HI, Wang D, Zhu H
Cell death and differentiation 2026 Jan;33(1):111-125
Cell death and differentiation 2026 Jan;33(1):111-125
Metabolic and epigenetic abnormalities cause hepatic fibrogenesis in metabolic dysfunction-associated steatohepatitis model mice.
Miura A, Ikeda S, Kono Y, Kawate K, Hosono T, Seki T
The Journal of biological chemistry 2026 Jan;302(1):110959
The Journal of biological chemistry 2026 Jan;302(1):110959
Histone H4K8 lactylation modulated immunosuppressive properties by promoting FAP transcription and ECM remodeling.
Huang C, Liu T, Zhao Y, Wang M, Wang D, Shen B, Zhu W, Sun L
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2026 Jan;29(1):70-82
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2026 Jan;29(1):70-82
20-hydroxyecdysone promotes brain development via upregulating MMP2 expression during metamorphosis in Helicoverpa armigera.
Tian C, Feng PY, Wang L, Liu TW, Li YX, Zhao XF
PLoS genetics 2026 Jan;22(1):e1012032
PLoS genetics 2026 Jan;22(1):e1012032
Periplocin and bufalin induce cardiotoxicity by regulating AMPK/SIRT1/PGC-1α pathway to inhibit energy metabolism and trigger autophagy.
Gao X, Zhang J, Lin Y, Tian K, Tu J, Wu Z, Lv X, Hu H, Liu X, Lin S, Zhu A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157688
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157688
Safranal accelerates diabetic wound healing by suppressing ferroptosis through modulation of transcription factor Forkhead Box O3.
Wang Z, Zhu Y, Chen L, Hu Z, Cheng B, Lin Z, Li K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157675
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157675
HDAC6 orchestrates metastatic and immunosuppressive programs in small cell lung cancer through S100A2-TGF-β/SMAD and CSF1R signaling.
Jiang Y, Yu J, Wang T, Du Q, Wang J, Lu Y, Xu Q, Liu H, Li X, Tong L, Qin T, Huang D
Molecular cancer 2026 Jan 7;25(1):33
Molecular cancer 2026 Jan 7;25(1):33
Dictamnine inhibited keratinocyte hyperproliferation and alleviated psoriasis-like dermatitis via blocking HIF1A-mediated ferroptotic pathway.
Wang W, Zhang J, Jiang SL, Rao ZM, Liu H, Wang L, Cai CL, Xu XC, Yu CH, Wang W
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120607
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120607
Autocatalytic Signal Amplification via Orthogonal Recognition of Dual Proteins on the Surface of Serum Extracellular Vesicles for Precise Diagnosis of Prostate Cancer.
Tao J, Yang L, Chen J, Yue S, Song C, Liang C, Zhou J, Wang H
ACS sensors 2026 Jan 23;11(1):181-189
ACS sensors 2026 Jan 23;11(1):181-189
The GC-derived exosomal LncRNA DARS-AS1 activates Wnt/β-catenin pathway to drive angiogenesis by regulating miR-605-5p/BCL9.
Gao X, Gao S, Yang Y, Xing D, Mao Z, Ren Y, Chen J
Journal of cancer research and clinical oncology 2026 Jan 21;152(1):42
Journal of cancer research and clinical oncology 2026 Jan 21;152(1):42
Betaine Inhibits Ferroptosis After Intracerebral Hemorrhage by Activating the Nrf2/HO-1 Pathway.
Chen J, Lu X, Liu S, Hu W, Zhou X, Wang Z
Antioxidants (Basel, Switzerland) 2026 Jan 21;15(1)
Antioxidants (Basel, Switzerland) 2026 Jan 21;15(1)
Defining the Critical Role of α-Gustducin for NF-κB Inhibition and Anti-Inflammatory Signal Transduction by Bitter Agonists in Lung Epithelium.
Fang Y, Wang Q, Wu S, He X, Wang S, Ma R, Zhao H, Zhao X, Wang X, Zhang Y
International journal of molecular sciences 2026 Jan 19;27(2)
International journal of molecular sciences 2026 Jan 19;27(2)
Narciclasine Alleviates Endothelial Inflammation and Atherosclerosis Initiation by Inhibiting Histone Lactylation-Mediated NF-κB Activation.
Wang Z, Zhang Z, Xin R, Ma M, Sun Z, Li Z, Zhang C, Liu L, Wu Z, Zhang Y, Chen Y
Inflammation 2026 Jan 16;49(1):49
Inflammation 2026 Jan 16;49(1):49
Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity.
Liu D, Zhou C, Wang X, Luo Z, Xu R, Huo S, Guo L, Luo X, Yang S, Click A, Vancil J, Barajas P, Mijares V, Baniasadi H, Yan N, Rehwinkel J, Hancks DC, Chen EH, Liang S, Zhong Z
Science (New York, N.Y.) 2026 Jan 15;391(6782):eadq9006
Science (New York, N.Y.) 2026 Jan 15;391(6782):eadq9006
O-GlcNAcylation of NONO mediates alternative splicing of SETMAR and facilitates NHEJ repair.
Li M, Tian H, Zhou Z, Jiang Y, Guo X, Qin W, Zhang H, Jiao Y, Guo S, Wu C
Genome biology 2026 Jan 14;27(1):26
Genome biology 2026 Jan 14;27(1):26
Wnt3a promotes in situ dentin formation through NKD1-MSX1 axis-mediated odontogenic differentiation of dental pulp stem cells.
Du H, Li Q, Zhou C, Xu J, Gao K, Li Z, Xu Y, Liu O, Li B, Xu J, Wang J, Kagami H, Li X, Chen S, Zhou J
International journal of oral science 2026 Jan 13;18(1):9
International journal of oral science 2026 Jan 13;18(1):9
Promoting the nuclear retention of HMGB1 attenuates astrocyte senescence.
Zhang N, Yang F, Shi J, Tang X, Fan A, Li W, Zhang F, Chai S, Chen Q, Wang C, Xu Y, Gong F, Lu Y, Zheng F
Journal of neuroinflammation 2026 Jan 12;23(1):55
Journal of neuroinflammation 2026 Jan 12;23(1):55
T-2 toxin exacerbates chondrocyte extracellular matrix degradation potentially through YAP/NLRP3/GSDMD-mediated pyroptosis.
Li H, Xing Z, Dong H, Qi F, Yu Q, Li J, Jiang H, Wang C, Li J, Zhang B, Yu J
International immunopharmacology 2026 Jan 1;168(Pt 2):115890
International immunopharmacology 2026 Jan 1;168(Pt 2):115890
SA supplementation during lactation promotes learning and memory by reducing H3K27me3 levels.
Huang C, Ai S, Wang M, Li C, Wang K, Nie M, Zhang H, Gu X, Wang HL
Journal of advanced research 2026 Feb;80:301-316
Journal of advanced research 2026 Feb;80:301-316
PXR ribosylation at E194 amplifies NAPQI in acetaminophen‒induced liver injury in mice, rescued by Schisandrin B.
Long JC, Liu CX, Wang MY, Liu CH, Zhang F, Liu ZQ, An L, Wang CY
Acta pharmacologica Sinica 2026 Feb;47(2):370-382
Acta pharmacologica Sinica 2026 Feb;47(2):370-382
Intranasal delivery of Odorranalectin-modified lipid nanoparticles for multi-targeted therapy of Alzheimer's disease.
Zhang Y, Yin C, Tian Y, Li X, Wang H, Han S, Chen H, Hou H
Materials today. Bio 2026 Feb;36:102764
Materials today. Bio 2026 Feb;36:102764
Mechano-matching hydrogel patch promotes myocardial infarction repair via YAP-Bcl-2 pathway activation.
Zhao Y, Shen J, Lin R, Huang J, Zou X, Hou H, Qiu X
Materials today. Bio 2026 Feb;36:102670
Materials today. Bio 2026 Feb;36:102670
Intestinal metabolite TMAO promotes CKD progression by stimulating macrophage M2 polarization through histone H4 lysine 12 lactylation.
Tang Y, Li Y, Yang X, Lu T, Wang X, Li Z, Liu J, Wang J
Cell death and differentiation 2026 Feb;33(2):314-326
Cell death and differentiation 2026 Feb;33(2):314-326
Cell death modulation dictates tissue-specific tropism of lumpy skin disease virus.
Wen Y, Wang T, Zhang S, Wang J, Li C, Liu C, Tang F, Dai J, Xue F
PLoS pathogens 2026 Feb;22(2):e1013982
PLoS pathogens 2026 Feb;22(2):e1013982
Endothelium-Treg Communication Through Extracellular Vesicle Transfer Exacerbates Acute Respiratory Distress Syndrome.
Liu X, Huang W, Zhang X, Li S, Wang H, Wu Z, Zi S, Wang L, Liu L, Yang Y, Xie J, Zheng M, Chao J, Qiu H
Journal of extracellular vesicles 2026 Feb;15(2):e70235
Journal of extracellular vesicles 2026 Feb;15(2):e70235
COL1A1 promotes clear cell renal cell carcinoma progression through the Wnt/β-catenin signaling pathway.
Ji X, Yun Y, Zhu Z, Wu T, Ruan M, Fan Y, Zhang Q
Cellular signalling 2026 Feb;138:112259
Cellular signalling 2026 Feb;138:112259
Icaritin Ameliorates Cisplatin-Induced Mitochondrial Metabolic Dysfunction-Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy.
Luo P, Chen J, An Y, Meng K, Zhou W, Li W, Liu J, Zhao W, He W, Cao T, Huang J, Feng S, Yang S, Hu H, Liao J, He H, Hao M, Zhang Q, Wang J, Gao Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(7):e06712
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(7):e06712
Histone lactylation increases CXCL1 expression for neutrophil infiltration and immune escape in pancreatic cancer.
Zhang P, Ma J, Wan Y, Li C, Liu L, He M, Zhang N, Ma Y, Hu J, Zhao L, Zhong Z, Lei X, Gong J, Zeng T, Ma J, Da Y, Zhou Z, Yang J, Wang X, Gong T, Zhang C
Nature communications 2026 Feb 9;17(1)
Nature communications 2026 Feb 9;17(1)
HSPA5 promotes YAP/TAZ stability independently of the Hippo pathway and induces proneural-to-mesenchymal transition in glioblastoma.
Gui S, Yu W, Song Z, Peng L, Luo H, Huang K, Xiao J, Xie J, Cai S, Yuan S, Tao Z, Cheng Z
Cell death & disease 2026 Feb 7;17(1):208
Cell death & disease 2026 Feb 7;17(1):208
Cuproptosis promotes inflammatory osteolysis via GYS1-mediated glycogen metabolism.
Zhou L, Mao H, Wen Y, Chen Z, Zhang L
International journal of oral science 2026 Feb 3;18(1):13
International journal of oral science 2026 Feb 3;18(1):13
The Mislocalization of TDP-43 to Mitochondria Impairs Myotube Maturation.
Wan Y, Yu Z, Yang J, Zhang W, Yu M, Meng L, Wang Z, Yuan Y, Ruan L, Deng J, Wang P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 28;40(4):e71603
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 28;40(4):e71603
Lactate Promotes Endothelial-Mesenchymal Transition via Mediating Twist1 Lactylation in Hypoxic Pulmonary Hypertension.
Li X, Wang F, Liu N, Liu Y, Yu W, Tang M
International journal of molecular sciences 2026 Feb 27;27(5)
International journal of molecular sciences 2026 Feb 27;27(5)
Matrix Metalloproteinase 7 Mediates Epithelial-Mesenchymal Transition to Promote Liver Fibrosis Through E-cadherin/β-catenin Pathway in Biliary Atresia.
Rong L, Tang J, Li X, Zhang M, Chi S, Zhou Y, Zhang X, Cao G, Li Y, Tang S
International journal of molecular sciences 2026 Feb 26;27(5)
International journal of molecular sciences 2026 Feb 26;27(5)
A novel molecule ZYZ329 targeting histone methyltransferase SMYD3 suppresses pathological angiogenesis via the driven mitochondrial ROS/HIF-1α/VEGFA axis.
Ye Q, Cai J, Lu X, Zhu Q, Li Q, Ren M, Ding Q, Mao Y, Zhu YZ
Journal of translational medicine 2026 Feb 24;24(1)
Journal of translational medicine 2026 Feb 24;24(1)
Alpha-Ketoglutarate Drives an Osteogenic and Extracellular Matrix Gene Program in Periodontal Ligament Fibroblasts via Selective Reduction of H3K27me3.
Hasegawa R, Suzuki S, Fahreza RR, Tsai SH, Daidouji Y, Omori M, Kajikawa T, Yamada S
Biology 2026 Feb 24;15(5)
Biology 2026 Feb 24;15(5)
Nicotinamide Mononucleotide Decreases Secretion of Proinflammatory Cytokines via the NAD (+) /SIRT1/p65 Axis.
Zhang D, Li Z, Meng X, Wang T, Miao Z, Deng H
ACS omega 2026 Feb 24;11(7):11511-11519
ACS omega 2026 Feb 24;11(7):11511-11519
PDHA1-acetylation signaling suppresses cuproptosis to attenuate anti-androgen effect in prostate cancer.
Zhuang R, Zhou Q, Cheng B, Peng S, Xiong Z, Xie Z, Lin W, Su T, Li Z, Yao K, Wu Z, Huang H, Li K
Cell death & disease 2026 Feb 23;17(1)
Cell death & disease 2026 Feb 23;17(1)
Aurkb deficiency disrupts microglial development, homeostasis and hinders remyelination following cuprizone-induced demyelination.
Yan W, Xiang D, Du L, Zhu D, Jia Q, Liu Y, Wang S, Liu L, Guan H, Zhao Y, Jiang G, Gao S, Wang H
iScience 2026 Feb 20;29(2):114718
iScience 2026 Feb 20;29(2):114718
Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer's disease pathogenesis.
Liu Y, Fan M, Ye Y, Cheng HY, Sun S, Qiu Z
bioRxiv : the preprint server for biology 2026 Feb 20;
bioRxiv : the preprint server for biology 2026 Feb 20;
Disruption of FGL2 induces TFEB-dependent lysosomal degradation of PD-L1 and enhances the efficacy of anti-PD1 therapy in hepatocellular carcinoma.
Han M, Guan Q, Yan F, Wang M, Xi D, Ning Q
Cell communication and signaling : CCS 2026 Feb 2;24(1)
Cell communication and signaling : CCS 2026 Feb 2;24(1)
Apoptotic vesicles from endothelial cells promote endothelial progenitor cell differentiation and angiogenesis via miR-30a-5p mediated activation of the EGFR/PI3K/AKT/VEGF pathway.
Lei S, Zhou J, Hu X, Xie J, Wang L, Kou T, Xu L, Wang J, Cheng Y, Zhao S, Zhang T, Lu D, Chen Y, Ying Y, Xin X, Xu X, Zhang Y, Wang J, Qiu C, Cheng G, Lyu Q, Lin M, Pan Y, Cao T
Stem cell research & therapy 2026 Feb 2;17(1)
Stem cell research & therapy 2026 Feb 2;17(1)
Targeting AARS1-dependent lactylation improves neuronal process plasticity and mitigates cognitive deficits in sepsis-associated encephalopathy.
Luo S, Lyu Z, Huang H, Zhao J, Li Y, Luo Y
Brain, behavior, and immunity 2026 Feb 17;135:106493
Brain, behavior, and immunity 2026 Feb 17;135:106493
Discovery of CZL-077 as a potent, selective, and orally active p300/CBP bromodomain inhibitor with improved in vivo antitumor efficacy.
Chen Z, Zhang Y, Shen H, Yang H, Zhang Y, Shi Q, Yang Y, Wang Y, Zhou R, Tan X, Wan H, Xu Y, Huang X, Li Y
European journal of medicinal chemistry 2026 Feb 15;304:118489
European journal of medicinal chemistry 2026 Feb 15;304:118489
KIF20A inhibits TRIM21-dependent ubiquitination of DHX9 to boost SOX2 stability, enhancing OSCC stemness and ferroptosis resistance.
Zhang Z, Li Y, Hu J, Tang X, Li Z, Sun X, Feng D, Yao Y, Mao C, Tao Y, Xie L, Luo H, Li Y, Yu X, Peng X, Cong L, Jiang Y
Cell death & disease 2026 Feb 11;17(1):218
Cell death & disease 2026 Feb 11;17(1):218
Structural characterization and anti-hepatic fibrosis effects of a novel polysaccharide from Astragalus complanatus seeds.
Zhu ZF, Wang SY, Liu XF, Liu N, Dong DC, Qi YC, Li N, Wang N, Tan J, Jia C, Cai RQ, Li XQ, Cao W
Carbohydrate polymers 2026 Feb 1;373:124661
Carbohydrate polymers 2026 Feb 1;373:124661
EP300 attenuates ferroptosis and stimulates proliferation, migration, and fibrosis of keloid fibroblasts via YY1/GPX4 axis.
Jin J, Wang K, Lu C, Yao C, Xie F
Cell cycle (Georgetown, Tex.) 2026 Dec;25(1):1-16
Cell cycle (Georgetown, Tex.) 2026 Dec;25(1):1-16
Apolipoprotein C3 exacerbates vascular calcification by promoting ferroptosis via the TLR2/AMPK pathway in vascular smooth muscle cells.
Zhou Z, Chen J, Wang H, Han Y, Liu C, Shen Q, Dong Z, Lu K, Zhai C, Xu Y, Zhang L, He L, Fang Y, Zhang L, Wang Y, Xian X, Yao L, Dong E, Huang W
Redox biology 2026 Apr;91:104088
Redox biology 2026 Apr;91:104088
An intelligent nanoliposome alleviates disc degeneration and discogenic pain by inhibiting neurovascular ingrowth via a "Soil-conditioning, seed-modulating, and weeds-suppressing" strategy.
Li F, Shi Y, Liu J, Yang Y, Yan C, Sun X, Zhang Z, Zhang B, Wang Q, Du M, Wang Z, Sun J, Xu X, Sun K, Sun J, Wang Y, Shi J
Bioactive materials 2026 Apr;58:157-182
Bioactive materials 2026 Apr;58:157-182
HMGA2 promotes hepatocellular carcinoma progression by regulating tumor-associated macrophage via Notch1/CCL2 signaling.
Xing Z, Xun J, Deng L
Molecular and cellular biochemistry 2026 Apr;481(4):1677-1693
Molecular and cellular biochemistry 2026 Apr;481(4):1677-1693
Electroacupuncture regulates neuronal ferroptosis and ferritinophagy through lysosomal-mediated TFEB activation in cerebral ischemia-reperfusion.
Tang B, Xu X, Zhao W, Zhou Q, Du G, Wang H
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2026 Apr;46(4):963-975
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2026 Apr;46(4):963-975
PMM2 interacts with TRIM28 to recruit E2F4 and promote KIFC3-mediated tumor glycolysis and colorectal cancer progression.
Peng Z, Ma B, Song Z, Zhao Y, Yang Y, Liu Y, Li C, Zhang Y
Oncogene 2026 Apr;45(12):1145-1160
Oncogene 2026 Apr;45(12):1145-1160
YAP Regulates Microglial Anti-Inflammatory Responses and Alleviates Cognitive Impairment Through the IL-33/ST2 Pathway after Traumatic Brain Injury.
Zhao R, Gao SQ, Wang X, Li T, Gao CC, Han YL, Qiu JY, Miao SH, Sun Y, Zheng XB, Jin WX, Zhou ML
Journal of neurotrauma 2026 Apr;43(7-8):641-659
Journal of neurotrauma 2026 Apr;43(7-8):641-659
Multifunctional hydrogel delivery of mesenchymal stem cell secretome suppresses neutrophil extracellular trap formation and promotes diabetic wound healing via PGE2/BMAL1 pathway.
Lin L, Liang X, Xu Z, Li Y, Guo Z, Liu L, Liu H, Cai Q, Chen Y, Yu Z, Li Y
Biomaterials 2026 Apr;327:123764
Biomaterials 2026 Apr;327:123764
ANGPT2/Tie2 Enhances H3K18la-Mediated Macrophage M2 Polarization to Promote Endothelial Cell Proliferation in the Chronically Ischaemic Brain.
Tai C, Ling C, Yang Y, Mo N, Yao C, Lv S, Zhang B, Wang H, Chen C
CNS neuroscience & therapeutics 2026 Apr;32(4):e70879
CNS neuroscience & therapeutics 2026 Apr;32(4):e70879
ANKRD62 Modulates NF-κB Signaling to Promote Proliferation and Migration in UCEC.
Hao C, Li Y, Li Z, Fu L, Lin S
Cancer medicine 2026 Apr;15(4):e71822
Cancer medicine 2026 Apr;15(4):e71822
Ascites circRNA ASCOR Drives Platinum Resistance of High-Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation.
Liu H, Zhu C, Yao X, Liu Y, Zhu J, Li Y, Xu H, Peng C, Shan G, Chen L, Zhou Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(23):e18922
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(23):e18922
Identification of A p300-SP1-BRD4 Transcriptional Axis as a Key Driver of AR Hyperactivation in Polycystic Ovarian Syndrome.
Zhu Z, Wang Y, Chen H, Yu X, Wang T, Weng Y, Guo M, Huang Y, Tao G, Cao W, Wang Y, Wang D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(23):e18185
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(23):e18185
Discovery of p300 histone acetyltransferase inhibitors bearing an imidazo[4,5-b]pyridine-2-one scaffold for the treatment of multiple myeloma.
Xiong Y, Tan X, Yang H, Wang Y, Shi Q, Zhang Y, Lei X, Li Y, Huang X, Chen Z
European journal of medicinal chemistry 2026 Apr 5;307:118646
European journal of medicinal chemistry 2026 Apr 5;307:118646
Mechanisms of Mechanical Stress-Induced Vascular Remodeling via the Lactate-PKM2 Axis and Implications for Microgravity Adaptation.
Li N, Liu L, Wang D, Wang J, Tie Y, Li X, Li J, Gao Y, Yang C, Wang Y
International journal of molecular sciences 2026 Apr 5;27(7)
International journal of molecular sciences 2026 Apr 5;27(7)
Free Nε-(carboxymethyl)-lysine promotes diabetic kidney disease progression via RAGE/NF-κB/NLRP3 pathway-mediated podocyte PANoptosis.
Zhang L, Chen L, Guo W, Cai L, Zeng X, Liu Y, Kang C, Huang X, Fu W
Free radical biology & medicine 2026 Apr 30;252:112-131
Free radical biology & medicine 2026 Apr 30;252:112-131
Engineered CAR-monocytes coordinate fibrosis clearance and cardiac regeneration following myocardial infarction.
Wu Z, Zou X, Chen C, Zhou M, Yue X, Guo D, Gao Y, Ma C, Han Q, Yang D, Zang D, Song R, Li Y, Pang S, Ren H, Zhang W, Zhang M, Zhang Y, Yang J, Jiang X, Zhang C
Cell stem cell 2026 Apr 24;
Cell stem cell 2026 Apr 24;
Porcine hemagglutinating encephalomyelitis virus nucleocapsid protein targets RIG-I and IRF3 to evade IFN immunity.
Mu S, Bai Y, Qiu R, Zhang F, Shi J, Lan Y, Gao F, He W, Li Z
Journal of virology 2026 Apr 21;100(4):e0211225
Journal of virology 2026 Apr 21;100(4):e0211225
LENG8 mediates RNA nuclear retention and degradation in eukaryotes.
Tian L, Liu L, Yoon Y, Soles LV, Valdez M, Jeong J, Yu C, Huang L, Shi Y
Molecular cell 2026 Apr 16;86(8):1478-1494.e8
Molecular cell 2026 Apr 16;86(8):1478-1494.e8
Transcription Factor StHRAV1 Negatively Regulates Thermotolerance by Modulating ROS Accumulation in Potato.
Chen X, Shang L, Zhang M, Wen S, Li Y, Li M, Jian H, Lv D
Journal of agricultural and food chemistry 2026 Apr 15;74(14):11418-11437
Journal of agricultural and food chemistry 2026 Apr 15;74(14):11418-11437
LTF regulates glioblastoma progression and temozolomide resistance via the NF-κB signaling pathway.
Gao L, Xiao H, Lu H, Ma J, Zhu H
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2025;58:e13821
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2025;58:e13821
PGC-1α agonist ZLN005 ameliorates OVA-induced asthma in BALB/c mice through modulating the NF-κB-p65/NLRP3 pathway.
Fang R, Cheng Y, Chen P, Hu J, Yang L
Iranian journal of basic medical sciences 2025;28(6):710-717
Iranian journal of basic medical sciences 2025;28(6):710-717
Sulforaphane alleviates membranous nephropathy by inhibiting oxidative stress-associated podocyte pyroptosis.
Lv D, Chu L, Du Y, Li C, Bao N, Su Y, Wang G, Zheng Y, Yu Y
Iranian journal of basic medical sciences 2025;28(2):237-244
Iranian journal of basic medical sciences 2025;28(2):237-244
Metformin Alleviates Liver Metabolic Dysfunction in Polycystic Ovary Syndrome by Activating the Ethe1/Keap1/PINK1 Pathway.
Xie Y, Tian Y, Huang J, Deng W, Li X, Liu Y, Liu H, Gao L, Xie Q, Yu Q
International journal of biological sciences 2025;21(8):3505-3526
International journal of biological sciences 2025;21(8):3505-3526
β-estradiol alleviates hypoxic-ischemic brain damage in neonatal rats through the GPER1-mediated AKT/NF-κB signaling pathway.
Zhang G, Yuan D, Lv T, Li H, Zhang Y, Ding Y, Cui J, Li M, Yu J, Chen J, Xu X
Archives of medical science : AMS 2025;21(4):1612-1630
Archives of medical science : AMS 2025;21(4):1612-1630
FKBP10 Promotes the Muscle Invasion of Bladder Cancer via Lamin A Dysregulation.
Zhao X, Wang J, Tian S, Tang L, Cao S, Ye J, Cai T, Xuan Y, Zhang X, Li X, Li H
International journal of biological sciences 2025;21(2):758-771
International journal of biological sciences 2025;21(2):758-771
TERT translocation as a Novel condition in Intrauterine Growth Restriction rats with early catch-up growth.
He GQ, Dai YL, Huang Z, Ling F, Li P
PloS one 2025;20(6):e0312221
PloS one 2025;20(6):e0312221
Chlorogenic acid inhibits NLRP3 inflammasome activation through Nrf2 activation in diabetic nephropathy.
Bao L, Gong Y, Xu W, Dao J, Rao J, Yang H
PloS one 2025;20(1):e0316615
PloS one 2025;20(1):e0316615
A Peptide Encoded by lncRNA HOXB-AS3 Promotes Cigarette Smoke-Induced Inflammation in Bronchial Epithelial Cells via EZH2-Mediated H3K27me3 Modification.
Lin M, Zhou X, Yang Y, Xie P, Li Q, He C, Lin Q, Wei X, Ding Y
International journal of chronic obstructive pulmonary disease 2025;20:1543-1553
International journal of chronic obstructive pulmonary disease 2025;20:1543-1553
Liver-specific Bcl3 Knockout Alleviates Acetaminophen-induced Liver Injury by Activating Nrf2 Pathway in Male Mice.
Gao J, Lu W, Xin Y, Ma H, Sheng X, Gao G, Kang X, Jiang S, Zhao Y, Lv Y, Niu Y, Liang Y, Wang H
Cellular and molecular gastroenterology and hepatology 2025;19(6):101483
Cellular and molecular gastroenterology and hepatology 2025;19(6):101483
Lobetyolin Suppressed Osteoclastogenesis and Alleviated Bone Loss in Ovariectomy-Induced Osteoporosis via Hindering p50/p65 Nuclear Translocation and Downstream NFATc1/c-Fos Expression.
Xiu C, Luo H, Huang W, Fan S, Yuan C, Chen J, Xu C, Yao C, Hong D, Zhang L
Drug design, development and therapy 2025;19:4689-4715
Drug design, development and therapy 2025;19:4689-4715
Unveiling the Novel Anti - Tumor Potential of Digitonin, a Steroidal Saponin, in Gastric Cancer: A Network Pharmacology and Experimental Validation Study.
Lu D, Huang L, Weng C
Drug design, development and therapy 2025;19:2653-2666
Drug design, development and therapy 2025;19:2653-2666
Remimazolam Suppresses Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury by Regulating AKT/GSK-3β/NRF2 Pathway.
Duan M, Yu N, Liu J, Zhao Y, Zhang J, Song S, Wang S
Drug design, development and therapy 2025;19:111-128
Drug design, development and therapy 2025;19:111-128
Effects of ADRM1 on osteoblast differentiation and mineralization in osteoporosis.
Zhuang H, Lin Y, Lin C, Zheng M, Yao X, Xu Y
American journal of translational research 2025;17(1):416-428
American journal of translational research 2025;17(1):416-428
COL6A2 drives clear cell renal cell carcinoma progression via integrin-dependent modulation of Wnt/β-catenin signaling.
Ji X, Yun Y, Zhu Z, Wu T, Ruan M, Fan Y, Zhang Q
Journal of Cancer 2025;16(15):4426-4439
Journal of Cancer 2025;16(15):4426-4439
NETs drive myocardial fibrosis in hypertension via an NF-κB/ferroptosis axis.
Tu Q, Gong X, Yuan X, Tang Y, Huang R, Jiang Q, Li W
Frontiers in immunology 2025;16:1712786
Frontiers in immunology 2025;16:1712786
GDF15 orchestrates mitochondrial-immune crosstalk via SMAD7-HIF-1α-PKM2 cascade to attenuate septic liver injury.
Kuang X, Niu Z, Liu W, Huang Z, Li S, Zhang Y, Wang L, Cai X, Wang F, Zhang P
Frontiers in immunology 2025;16:1712741
Frontiers in immunology 2025;16:1712741
Treatment With Schistosoma Japonicum Peptide SJMHE1 and SJMHE1-Loaded Hydrogel for the Mitigation of Psoriasis.
Liu X, Wang S, Jiang Y, Luo X, Yang Y, Huo L, Ye J, Zhou Y, Yang Z, Du F, Dong L, Mao C, Wang X
Psoriasis (Auckland, N.Z.) 2025;15:85-104
Psoriasis (Auckland, N.Z.) 2025;15:85-104
Histone lactylation exacerbates acute lung injury in septic mice by promoting ferroptosis in pulmonary microvascular endothelial cells.
Fang P, Li S, Lu ZQ, Xia DL, Xu MM, Pan JJ, Fu L, Sun GY, You QH
Burns & trauma 2025;13:tkaf056
Burns & trauma 2025;13:tkaf056
Flufenamic acid inhibits pyroptosis in ischemic flaps via the AMPK-TRPML1-Calcineurin signaling pathway.
Chen L, Yang N, Chen K, Huang Y, Liu X, Yu G, Wang F, Gou Y, Wang Y, Lu X, Wang Y, Zhu L, Gao W, Ding J
Burns & trauma 2025;13:tkaf007
Burns & trauma 2025;13:tkaf007
Protosappanin A protects against pathological cardiac hypertrophy by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis via activation of the Nrf2 signaling pathway.
He Q, Zheng Y, Yan X, Lv S, Yu B
Frontiers in cardiovascular medicine 2025;12:1682641
Frontiers in cardiovascular medicine 2025;12:1682641
Calycosin inhibits porcine reproductive and respiratory syndrome virus replication and activates RIG-I/IRF3 signaling pathway.
Chang Y, Li Z, Wang M, Pei K, Chang X, Ma J
Frontiers in veterinary science 2025;12:1674259
Frontiers in veterinary science 2025;12:1674259
Nutrients regulation of skin cells from canines and cats via Wnt/β-catenin signaling pathway.
Sun X, Ma Y, Gao Y, Li J, Li Y, Lv L
Frontiers in veterinary science 2025;12:1486201
Frontiers in veterinary science 2025;12:1486201
Sestrin2 Regulates Mitochondrial Function and Autophagy via Nrf2/SIRT3 Signaling to Ameliorate Hypoxia/Reoxygenation-Induced Rat's Cardiomyocyte Injury.
Liu T, Kong J, Li Z, Xi S, Liu L
Drug development research 2025 Sep;86(6):e70150
Drug development research 2025 Sep;86(6):e70150
KDM4C regulates trophoblast proliferation and migration in preeclampsia via the NFATc4/Wnt pathway.
Shao C, Jia Y, Qiao S, Gao Q, He T, Meng Y, He J, Shan Y
International journal of biological macromolecules 2025 Sep;321(Pt 3):146320
International journal of biological macromolecules 2025 Sep;321(Pt 3):146320
Benserazide‑mediated targeting hexokinase 2 enhances the cytotoxicity of cisplatin in non-small cell lung cancer cell models.
Wang K, Wang S, Shan W, Huang S, Fang T, Zhou Y, Liu L, Sha O, Tam KY
Biochemical pharmacology 2025 Sep;239:117071
Biochemical pharmacology 2025 Sep;239:117071
IFITM1 promotes proliferation, migration and macrophage-like transdifferentiation of vascular smooth muscle cells via c-Src/MAPK/GATA2/E2F2 pathway in atherosclerosis.
Huang QH, Tang XY, Huang QY, Zhi SB, Zheng XQ, Gan CY, Huang MF, Pan ZF, Zhong ZX
Biochemical pharmacology 2025 Sep;239:117014
Biochemical pharmacology 2025 Sep;239:117014
Alexidine dihydrochloride enhances the sensitivity of human hepatocellular carcinoma to disulfidptosis via ATF4-DDIT3 activation.
Li M, Xu J, Du K, Wang G, Feng Y, Liu P
Free radical biology & medicine 2025 Sep;237:585-599
Free radical biology & medicine 2025 Sep;237:585-599
Regulatory role of ATF2 in trophoblast ferroptosis via the PI3K/Akt/Nrf2 pathway in gestational diabetes mellitus.
Xia D, Zhang Y, Zhang C, Wang H
Journal of diabetes investigation 2025 Sep;16(9):1720-1732
Journal of diabetes investigation 2025 Sep;16(9):1720-1732
Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone-Glucocorticoid Receptor-LAMA5 Axis.
Zhang C, Song Y, Jin X, Xu Q, Ye H, Wu Z, Lin H, Hu J, Huang C, Zhou J, Lian J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e14659
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e14659
Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia-Reperfusion Injury.
Jin H, Li Z, Tan S, Xiao Q, Li Q, Ye J, Zhou Y, Wan Y, Liu Q, Menon BK, Hu B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e03722
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e03722
LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma.
Zhang Y, Zhou Y, Zhang Y, Lv J, Shen Y, Zhang D, Liu B, Zhao W, Ju J, Zhu Q, Wang K, Feng N
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e16809
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e16809
Topoisomerase I Inhibition in ETV4-overexpressed Non-Small Cell Lung Cancer Promotes Replication and Transcription Mediated R-Loop Accumulation and DNA Damage.
Zhang J, Wang Y, Cao S, Xie SM, Liu B, Li Y, Hou Y, Meng X, Ruan M, Bu D, Kang J, Li R, Lou L, Wang J, Xing L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e09307
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e09307
A Novel Nuclear-Localized Micropeptide, MP60, Promotes Hepatocellular Carcinoma Progression via the Epithelial-Mesenchymal Transition.
Li C, Hong X, Setrerrahmane S, Sun X, Zhang X, Xu H
Cancers 2025 Sep 7;17(17)
Cancers 2025 Sep 7;17(17)
Epigenetic reprogramming of HDAC2 in CA1 excitatory neurons determines Pb-induced non-spatial memory deficits.
Wang M, Huang C, Ai S, Xia Y, Li C, Zhi Y, Wang K, Nie M, Gu X, Xu Y, Zhang H, Wang HL
Journal of hazardous materials 2025 Sep 5;495:138818
Journal of hazardous materials 2025 Sep 5;495:138818
Ipriflavone Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection via RIG-I/IRF3-Mediated Interferon Signaling.
Chang Y, Li Z, Pei K, Wang M, Chang X
Animals : an open access journal from MDPI 2025 Sep 29;15(19)
Animals : an open access journal from MDPI 2025 Sep 29;15(19)
IRS2/FOXO1 mitigates osteoarthritis by regulating chondrocyte autophagy and mitochondrial function.
Qin C, Chen K, Sun Y, Wang C, Yu Y, Zhu H, Zou G
Molecular medicine (Cambridge, Mass.) 2025 Sep 26;31(1):293
Molecular medicine (Cambridge, Mass.) 2025 Sep 26;31(1):293
TRIM21 promotes colorectal cancer development through regulating DNA replication by TCF3/MCM2/5 axis.
Zhang X, Yao H, Hou Y, Zhou K, Liang Y, Hou L, Zhang X, Wang W, Du L, Yao M, Wang J, Meng X
Cell death discovery 2025 Sep 25;11(1):422
Cell death discovery 2025 Sep 25;11(1):422
C19orf12 inhibits mitochondrial function and enhances the antitumor effects of metformin in non-small cell lung cancer.
Liu R, Zhao M, Zhang X, Wu H, Ren L, Lv J, Liu Z, Wang Q, Yao Z
Cell reports 2025 Sep 23;44(9):116163
Cell reports 2025 Sep 23;44(9):116163
Fluzoparib disrupts Golgi apparatus to inhibit O-GlcNAcylation and nuclear translocation of β-catenin to attenuate ovarian cancer invasion and metastasis.
Peng J, Liu J, Ning M, Han W, Wang H, Wang Z, Hong L, Liu C
International immunopharmacology 2025 Sep 23;162:115158
International immunopharmacology 2025 Sep 23;162:115158
Uncovering the Anti-Atherosclerotic Effect of Isoquercitrin via Microbiome Metabolic Modulation and Network Pharmacology.
Chen YY, Guo J, Xue SL, Ding LL, Wei BY, Wen SY
Journal of agricultural and food chemistry 2025 Sep 17;73(37):23469-23485
Journal of agricultural and food chemistry 2025 Sep 17;73(37):23469-23485
FOXO3 Protects Lens Epithelial Cells From UVB-Induced Oxidative Stress via the AMPK/FOXO3 Signaling Pathway.
Sun Y, Hong Y, Ning L, Xiao B, Ainiwaer M, Jiang Y, Ji Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 15;39(17):e71039
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 15;39(17):e71039
Design and synthesis of CDK9/EZH2 dual-target inhibitors to achieve synergistic antitumor effects.
Tian L, Xiao J, Zeng Y, Li Y, Wei A, Shen Q, Han Y, Chen Y, Hu Y
European journal of medicinal chemistry 2025 Sep 15;294:117773
European journal of medicinal chemistry 2025 Sep 15;294:117773
The Outer Membrane Protein Tp92 of Treponema pallidum Induces BeWo Cells Apoptosis and Oxidative Stress via the Nrf2/keap1 Pathway.
Huang S, Zhao Y, Xiong S, Liu Z, Ding X, Yao J, Lin T, Yu H, Zhang X, Zhao F
ACS infectious diseases 2025 Sep 12;11(9):2500-2514
ACS infectious diseases 2025 Sep 12;11(9):2500-2514
Aberrant WDR5 promotes the progression of cervical cancer through the YAP1- CTGF pathway.
Ma X, Xu Z, Wang X, Sun S, Zhang J, Tang R, Ling L, Wei B, Hu L, Wang E
Life sciences 2025 Sep 1;376:123712
Life sciences 2025 Sep 1;376:123712
Arsenic-induced hepatotoxicity: Mechanistic insights into TNFAIP3-mediated regulation of the NF-κB p65/IAPs Signaling Pathway.
Jin B, Li H, Zhang H, Liu L, Wan S, Zheng X, Li X, Wang N, He R, Wang K
Ecotoxicology and environmental safety 2025 Sep 1;302:118642
Ecotoxicology and environmental safety 2025 Sep 1;302:118642
Early-life ketone body signalling promotes beige fat biogenesis through changes in histone acetylome and β-hydroxybutyrylome.
Jiang CL, Lai PH, Yang PC, Lien CJ, Chu HC, Lin JD, Lin SJ, Yu IS, Lin FJ
Nature metabolism 2025 Oct;7(10):2045-2066
Nature metabolism 2025 Oct;7(10):2045-2066
SFRS8 Regulates Memory by Modulating RNA Splicing of Synaptic Genes.
Ding Z, Liu Q, Zhang J
Molecular neurobiology 2025 Oct;62(10):12523-12538
Molecular neurobiology 2025 Oct;62(10):12523-12538
4-Octyl Itaconate Attenuates Postmenopausal Osteoporosis by Inhibiting Ferroptosis and Enhancing Osteogenesis via the Nrf2 Pathway.
Li Y, Li Y, Li P, Yang L, Li H
Inflammation 2025 Oct;48(5):3326-3339
Inflammation 2025 Oct;48(5):3326-3339
OTUD1 downregulates PD-L1 expression by deubiquitinating STAT3 and promotes the immune response in ccRCC.
Liang H, Liu X, Guo W, Xiong W, Ren D, Liu W
Cellular oncology (Dordrecht, Netherlands) 2025 Oct;48(5):1349-1361
Cellular oncology (Dordrecht, Netherlands) 2025 Oct;48(5):1349-1361
Dapagliflozin ameliorates high glucose-induced epithelial-mesenchymal transition via up-regulating ACE2 mediated by EZH2 in diabetic nephropathy.
Wang S, Zhang X, Chong N, Chen D, Shu J, Wang R, Wang Q, Xu Y
Journal of endocrinological investigation 2025 Oct;48(10):2499-2509
Journal of endocrinological investigation 2025 Oct;48(10):2499-2509
HOMER3 orchestrates SRC-YAP1 activity that promotes tumor cell growth and antagonizes anti-tumor immunotherapy in prostate cancer.
Tong T, Lei H, Huang M, Yang Z, Dai X, Zou H, Guo Y, Luo J, Teng Q, Cao F, Pang J, Li P
Oncogene 2025 Oct;44(41):3895-3908
Oncogene 2025 Oct;44(41):3895-3908
The SLCO4A1-Mediated Transmembrane Transport of Lysionotin Attenuates Acute Lung Injury Through Activating the AMPK/Nrf2 Signaling Pathway.
Xiong D, Lin M, Xie W, Zhang X, Huang L, Deng L, Huang X, Liu W, Tang S
Phytotherapy research : PTR 2025 Oct;39(10):4404-4427
Phytotherapy research : PTR 2025 Oct;39(10):4404-4427
The long noncoding RNA SNHG12 defines KEAP1 stability and ferroptosis susceptibility by targeting E3 ligase TRIM25.
Guo Y, Zhu S, Wu W, Cai Y, Sehgal SA, Huang F, Wu H
The Journal of biological chemistry 2025 Oct;301(10):110689
The Journal of biological chemistry 2025 Oct;301(10):110689
METTL3-dependent m(6)A modification of SNAP29 induces "autophagy-mitochondrial crisis" in the ischemic microenvironment after soft tissue transplantation.
Yang N, Lai Y, Yu G, Zhang X, Shi J, Xiang L, Zhang J, Wu Y, Jiang X, Zhang X, Yang L, Gao W, Ding J, Wang X, Xiao J, Zhou K
Autophagy 2025 Oct;21(10):2168-2191
Autophagy 2025 Oct;21(10):2168-2191
Liraglutide suppresses ferroptosis by upregulation NRF2 in type 2 diabetic cardiomyopathy.
Chen X, Wang T, Gao Y, Wang GA, Guan J, Dai H
Peptides 2025 Oct;192:171429
Peptides 2025 Oct;192:171429
MitoQ for vitiligo by mitigating PARP1 translocation aberrations: Network pharmacology and experimental validation.
Xiong R, Jin S, Li Y, Dong T, Song X, Guan C
Biochimica et biophysica acta. Molecular cell research 2025 Oct;1872(7):119995
Biochimica et biophysica acta. Molecular cell research 2025 Oct;1872(7):119995
Impact of gut microbiome on radiotherapy and immunotherapy efficacy in microsatellite-stable colorectal cancer: role of propionic acid and B. fragilis.
Yu L, Guo Q, Gu X, Wang Z, Li J, Wang X, Xu Z, Wang Y, Zhang Y, Zhang Y, Ding Y, Chen Z, Chen K, Ding Y
British journal of cancer 2025 Oct;133(7):956-969
British journal of cancer 2025 Oct;133(7):956-969
EP300-interacting inhibitor of differentiation 3 is required for spermatogenesis in mice.
Zhang P, Zhang L, Yu L, Zhou X, Chen X, Zhou Y, Wang N, Zhu H
Andrology 2025 Oct;13(7):1901-1912
Andrology 2025 Oct;13(7):1901-1912
PBAF/cBAF reorganization on H3.3 chromatin regulates BMAL1 activity in the absence of circadian negative feedback.
Letkova D, Peticca A, Sery D, Seki M, Suzuki Y, Padmanabhan K
Nature communications 2025 Oct 9;16(1):9000
Nature communications 2025 Oct 9;16(1):9000
Identification of human RNA Polymerase II interactors at early stages of transcription.
Ozer A, Kang JJ, Tang Y, Yugandhar K, Yu S, DeBerardine MD, Omar K, Lis JT, Yu H
bioRxiv : the preprint server for biology 2025 Oct 8;
bioRxiv : the preprint server for biology 2025 Oct 8;
Hippocampal CaMKII-α β-hydroxybutyrylation induces memory deficits in mice with type 1 diabetes mellitus.
Li H, Chen R, Wang H, Tian J, Zhao Y, Cen X
Communications biology 2025 Oct 7;8(1):1435
Communications biology 2025 Oct 7;8(1):1435
LncRNA-like MMP14 RNA facilitates colorectal cancer metastasis by suppressing H3K27cr at the STARD13 promoter region.
Li M, Gao Y, Sun X, Zheng W, Zhang M, Wang C, Chu W, Yang X, Wang L, Zheng M, Xue W, Dong F, Pei D, Liao M
Cellular & molecular biology letters 2025 Oct 6;30(1):115
Cellular & molecular biology letters 2025 Oct 6;30(1):115
KAT2A-H3K79succ-Mediated SH2B3 Upregulation Promotes TNBC Metastasis Through Diminishing the Ubiquitin-Dependent Degradation of Vimentin.
Shi X, Hao R, Yang Z, Wang X, Lu Y, Wang X, Ji H, Ma S, Liu X, Hu J, Qi Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 31;39(20):e71140
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 31;39(20):e71140
CFDP1 is required for histone variant H2A.Z deposition by the human SRCAP chromatin remodeling complex.
Moro N, Yang D, Butty VL, Levine SS, Peterson CL, Boyer LA, Watanabe S
bioRxiv : the preprint server for biology 2025 Oct 31;
bioRxiv : the preprint server for biology 2025 Oct 31;
IgD in nucleus of pro-B cells promotes pro-B cells proliferation by regulating E2F3 expression.
Zhang Y, Hou Y, Yu M, Zhang X, Zhang S, Zhu Z, Xu W, Huang J, Qiu X
Cell & bioscience 2025 Oct 29;15(1):149
Cell & bioscience 2025 Oct 29;15(1):149
Helicobacter pylori VacA modulates TRAF1-mediated 4-1BB/NF-kappaB axis to induce host apoptosis and chronic inflammatory damage.
Yuan L, Yao S, Qu N, Li X, Yang X, Deng A, Zhang M, Cai T, Liang L, Liu Z, Liu X, Wang F
Molecular medicine (Cambridge, Mass.) 2025 Oct 24;31(1):317
Molecular medicine (Cambridge, Mass.) 2025 Oct 24;31(1):317
Ginsenoside Ro Targets BCAT1/2 to Suppress Ferroptosis: A Novel Therapeutic Strategy for Ischemic Cardioprotection.
Liu J, Wang F, Bai J, Qu S, Tao S, Liu C, Wang Q, Ding W, Lai Q, Zhang J
Journal of agricultural and food chemistry 2025 Oct 22;73(42):26683-26699
Journal of agricultural and food chemistry 2025 Oct 22;73(42):26683-26699
TDP-43 dysfunction leads to impaired proteostasis and predisposes mice to worse neurological outcomes after brain injury.
Rotunno MS, Fowler-Magaw M, Zhong J, O'Hara K, Wiggin EA, Cameron D, Stallworth K, Bouley J, McEachern H, Anadolu MN, Nickerson JA, Tapper AR, Molas S, Massi F, Henninger N, King OD, Bosco DA
bioRxiv : the preprint server for biology 2025 Oct 22;
bioRxiv : the preprint server for biology 2025 Oct 22;
Linking the production of reactive oxygen species to the expression of antimicrobial peptides through aquaporin in an arthropod.
Wei Z, Liu PP, Wang WG, Wang XW
Proceedings of the National Academy of Sciences of the United States of America 2025 Oct 21;122(42):e2502570122
Proceedings of the National Academy of Sciences of the United States of America 2025 Oct 21;122(42):e2502570122
Sodium nitrate protects against metabolic syndrome by sialin-mediated macrophage rebalance.
Li S, Wang Y, Zhang Z, Xu H, Wu S, Jin H, Han X, Liu Y, Wen X, Wu Y, Zhang Z, Hu L, Hu L, Zhang C, Wang J, Yan R, Chen M, Xiao G, Sun G, Zhang D, Wang S
Signal transduction and targeted therapy 2025 Oct 2;10(1):323
Signal transduction and targeted therapy 2025 Oct 2;10(1):323
Targeting PURPL RNA enabled rejuvenation of senescence cells via epigenetic reprogramming.
Wang J, Yang X, Su X, Yi W, Sun W, Wei J, Ning YQ, Yan J
Journal of translational medicine 2025 Oct 17;23(1):1127
Journal of translational medicine 2025 Oct 17;23(1):1127
SAP30BP aggravates mitochondrial-related ferroptosis in diabetic cardiomyopathy by regulating MFN2-ACSL4 axis.
Zhao T, Chen C, Zhao W, Han J, Omar Jan M, Lou H, Chen Z, Liu X, Jing S
European journal of pharmacology 2025 Oct 15;1005:178046
European journal of pharmacology 2025 Oct 15;1005:178046
Characterization of Corneal Defects in ATG7-Deficient Mice.
Volatier T, Mourier A, Mann J, Meshko B, Hadrian K, Cursiefen C, Notara M
International journal of molecular sciences 2025 Oct 14;26(20)
International journal of molecular sciences 2025 Oct 14;26(20)
Nano-Self-Assembled Particles Loaded with Aldehyde Dehydrogenase 2 Agonist Inhibit Ischemia-Reperfusion Injury of Transplanted Kidneys.
Hu Q, Lu Z, Yasen K, Liu A, Shi X, Ye Q, Zhong Z
ACS nano 2025 Oct 14;19(40):35853-35870
ACS nano 2025 Oct 14;19(40):35853-35870
Engineered extracellular vesicles for targeted FGF20 delivery enhance neuroplasticity and functional recovery in ischemic stroke.
Guo S, Wang Z, Shi R, Huang P, Fang Y, Chen S, Huang M, Hu J, Lu Y, Xu X, Zou Y, Ruan L, Li X, Lin L, Wang X
Journal of controlled release : official journal of the Controlled Release Society 2025 Oct 10;386:114080
Journal of controlled release : official journal of the Controlled Release Society 2025 Oct 10;386:114080
H3K18 lactylation in cancer-associated fibroblasts drives malignant pleural effusion progression via TNFR2(+) T(reg) recruitment.
Ye L, Xiang X, Wang Z, Zhang S, Xue Q, Wei X, Liu Y, Wang H, Ai J, Yang B, Chen L, Niu Y, Peng W, Zhou Q
Experimental & molecular medicine 2025 Nov;57(11):2671-2685
Experimental & molecular medicine 2025 Nov;57(11):2671-2685
Lactate Prevents Glucose Deprivation-Induced Parthanatos in Gastric Cancer Cells Through Alleviating Intracellular Reactive Oxygen Species.
Niu D, Xia Y, Qin X, Zhang M, Pan S, Yuan X, Tang G, Ai W, Liang Y, Li Z, Xie Z
Cell biology international 2025 Nov;49(11):1441-1453
Cell biology international 2025 Nov;49(11):1441-1453
Acteoside-containing caffeic acid is bioactive functional group of antifibrotic effect by suppressing inflammation via inhibiting AHR nuclear translocation in chronic kidney disease.
Wang YN, Wu X, Shan QY, Yang Q, Yu XY, Yang JH, Miao H, Cao G, Zhao YY
Acta pharmacologica Sinica 2025 Nov;46(11):2975-2988
Acta pharmacologica Sinica 2025 Nov;46(11):2975-2988
SENP3 Promotes Hepatocyte Steatosis via De-SUMOylation of SREBP2.
Tang Q, Peng W, Jiang X, Hu Y, Chen L, Fu N
Cell biochemistry and function 2025 Nov;43(11):e70141
Cell biochemistry and function 2025 Nov;43(11):e70141
Quercetin Targets HSP90α and Regulates Keap1/Nrf2 Pathway to Inhibit Crosstalk between Apoptosis and Ferroptosis in Oxidatively Stressed Neurons.
Liu J, Zhang ZZ, Yu GR, Han X
Journal of biochemical and molecular toxicology 2025 Nov;39(11):e70583
Journal of biochemical and molecular toxicology 2025 Nov;39(11):e70583
AMPK upregulates SOCS1 to promote TFEB nuclear transfer, enhances autophagy, inhibits macrophage M1 polarization and relieves acute lung injury.
Nie W, Gong C, Liu Y, Yang J, Dai Q, Liao Y, Li F
Molecular immunology 2025 Nov;187:240-253
Molecular immunology 2025 Nov;187:240-253
Protocatechuic aldehyde promotes diabetic wound healing by enhancing angiogenesis via H3K18 lactylation-mediated Acvr1c expression.
Fan W, You Y, Qu Y, Liu G
Molecular immunology 2025 Nov;187:152-165
Molecular immunology 2025 Nov;187:152-165
A Novel EYA1 Splicing Mutation in a Chinese Family With Branchio-Oto Syndrome: A Functional Analysis and Reproductive Intervention.
Chen A, Jiang L, Nie Z, Song J, He C, Mei L, Liu Y
Clinical and experimental otorhinolaryngology 2025 Nov;18(4):306-317
Clinical and experimental otorhinolaryngology 2025 Nov;18(4):306-317
CLOCK promotes proliferation of glioblastoma cells through acetylating PRPS1/2.
Liu J, Meng Z, Wang R, Zhao G, Ma Q, Jiang H, Ma L, Zhang X, Lu Z, Fang J
Journal of neuro-oncology 2025 Nov;175(2):657-671
Journal of neuro-oncology 2025 Nov;175(2):657-671
Histone Lactylation-Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells.
Li J, Tang C, Zhang X, Xing R, Guo Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e03897
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e03897
EGFR Targeted Liposomal PROTAC Assisted With Epigenetic Regulation as an Efficient Strategy for Osimertinib-Resistant Lung Cancer Therapy.
Wang D, Liu Y, Chen Y, Dai C, Hu W, Han J, Li Z, Yin F, Zhang Y, Shi C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e10197
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e10197
TGFB2/IGFBP5 activated by transcription factors STAT2 and SMAD3 initiate granulosa cell degeneration and cause follicular atresia in chickens.
Zhang W, Huang S, Guo A, Zhao Z, Zhang B, Li F, Bao H, Zhang H
Poultry science 2025 Nov;104(11):105747
Poultry science 2025 Nov;104(11):105747
Hydrogen activated the Nrf2/HO pathway to alleviate the cognitive decline in PD Drosophila after long-term sevoflurane exposure.
Li M, Ma B, Liang S, Pan X, Xie J, Wang H, Guo J
Neurotoxicology and teratology 2025 Nov-Dec;112:107560
Neurotoxicology and teratology 2025 Nov-Dec;112:107560
Dexmedetomidine alleviates ferroptosis caused by traumatic brain injury via the NRF2/HO-1/GPX4 pathway.
Hao JJ, Fang XL, Chen YY, Meng ZJ, Dong FX, Yang XF, Chu Z, Kuai JX, Bao H
Metabolic brain disease 2025 Nov 5;40(8):306
Metabolic brain disease 2025 Nov 5;40(8):306
Histone H3K18 lactylation-dependent epigenetic activation of RUNX2 orchestrates PI3K/AKT oncogenic signaling in laryngeal squamous cell carcinoma.
Fu D, Huang X, Lin Y, Yu F, Wu H
Journal of molecular histology 2025 Nov 4;56(6):361
Journal of molecular histology 2025 Nov 4;56(6):361
Neutrophil extracellular traps-STC1 positive feedback loop promotes immune evasion and metastasis in bladder cancer.
Cai T, Feng T, Zhang W, Ge Q, Peng L, Wang Y, Xie J, Deng X, Zhu W, Jin S, Wang J, Ye D, Zhu Y
Journal for immunotherapy of cancer 2025 Nov 28;13(11)
Journal for immunotherapy of cancer 2025 Nov 28;13(11)
The Frog Skin-Derived Antimicrobial Peptide Suppresses Atherosclerosis by Modulating the KLF12/p300 Axis Through miR-590-5p.
Fan F, Li MM, Qiu ZP, Li ZJ, Shang DJ
International journal of molecular sciences 2025 Nov 27;26(23)
International journal of molecular sciences 2025 Nov 27;26(23)
Pulchinenoside E2: A dual-functional STAT3 and autophagy inhibitor with potent anti-metastatic activity in triple-negative breast cancer.
Zheng D, Shu J, Gao B, Yu H, Liu K, Zheng M, Liu X, Chen G, Lin Y, Li Q, Sun Y, Zheng Y, Li B, Yang X, Wang K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157485
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157485
Rosmarinic acid alleviates doxorubicin-induced cellular senescence and cardiotoxicity by targeting the 14-3-3/Foxo1 signaling axis.
Fan C, Wu J, Hu S, Xia Y, Wei Z, Tang H, Jin W, Zhang Z, An P, Luo J, Luo Y, Zhu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157482
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157482
Biochanin A alleviates endothelial cell senescence via epigenetic regulation of the HDAC1/H3K4me3/NFKB1 axis.
Wang X, Tu Q, Mao A, Meng K, Lv J, Li B, Zhang T, Zhang H, Ding Y, Cao Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157385
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157385
PURA protein mislocalisation in the nucleus: mechanistic basis for transcriptional dysregulation and DNA unwinding deficits in a model of the p.L148Wfs*77 PURA variant.
Wang Y, Wang P, He J, Wang H, Liu S
Journal of medical genetics 2025 Nov 21;62(12):812-821
Journal of medical genetics 2025 Nov 21;62(12):812-821
Multi-omics analysis of the HMGB2(+) tumor epithelial cells in lactylation subgroups in colorectal cancer.
Hu S, Lou J, Ding M, Chen Y, Qin J, Liu Z, Li Y, Xiao Q, Xu M, Sun H, Pan Y, Wang S
Cell & bioscience 2025 Nov 19;15(1):158
Cell & bioscience 2025 Nov 19;15(1):158
Pyruvate kinase M2 -mediated histone lactylation alters three-dimensional genomic architecture in polycystic ovary syndrome.
Yu C, Liu T, Wang Y, Guo X, Chen Y, Zhao Y, Liu X, Huang W, Zhao S, Mo J, Hu H, Lv P, Wang X, Yang Z, Pan J, Ding G, Sheng J, Liu X, Yang H, Huang HF
Signal transduction and targeted therapy 2025 Nov 19;10(1):376
Signal transduction and targeted therapy 2025 Nov 19;10(1):376
Luteolin protects against alcoholic liver injury by restoring NRF2 stability to suppress ACSS2 nuclear accumulation.
Cao L, Lei Q, Dong Y, Meng C, Qi Q, Li L, Liu H, Liu X, Wang M
NPJ science of food 2025 Nov 17;9(1):234
NPJ science of food 2025 Nov 17;9(1):234
BRD4 inhibition suppresses histone H4 UFMylation to increase ferroptosis sensitivity through TXNIP.
Yang Z, Wang B, Guo B, Sun S, Li Y, Lu J, Cao X, Wang H, Wang X, Guo Y, Wu T
Cell death & disease 2025 Nov 17;16(1):843
Cell death & disease 2025 Nov 17;16(1):843
Molecular basis for CSB stimulation of the SNM1A DNA repair nuclease.
Roddan R, Schaich MA, Nathan WJ, Kis I, Pierangelini A, Henderson LR, van Wee R, Martin L, El-Sagheer A, Kukura P, Brown T, O'Brien D, Newman JA, Wilson DM 3rd, Schofield CJ, Van Houten B, McHugh PJ
Research square 2025 Nov 17;
Research square 2025 Nov 17;
Truncated APC impairs innate immune response by targeting MAVS on mitochondria in colorectal cancer.
Li SY, Wang XY, Wang J, Cao JH, Lv YR, Xie D, Wang FW
Journal of translational medicine 2025 Nov 10;23(1):1252
Journal of translational medicine 2025 Nov 10;23(1):1252
The N-terminal region of HASPIN regulates phosphorylation of AURKA and meiotic progression in spermatocytes.
Li H, Xu Y, Jiang X, Ren J, Wang Y, Zhang X, Gao M, Zhang L, Wang Y, Li Z, Wang S, Wang T, Wang M, Situ C, Guo X, Zhu H
Molecular and cellular endocrinology 2025 Nov 1;609:112645
Molecular and cellular endocrinology 2025 Nov 1;609:112645
DHYZ modulates hippocampal cholinergic pathway acetylation to ameliorate cognitive deficits post-ischemic stroke in rats.
Liu Z, Shi X, Xu X, Hu Y, Wen Y, Wang X, Ye L, Gong J
Brain research 2025 Nov 1;1866:149926
Brain research 2025 Nov 1;1866:149926
Phospho-TRIM21 orchestrates RPA2 ubiquitination switch to promote homologous recombination and tumor radio/chemo-resistance.
Zhang J, Chen B, Xu F, Wang R, Zhao X, Yao Z, Zhang J, Zhou S, Xu A, Wu L, Zhao G
Oncogene 2025 May;44(16):1106-1117
Oncogene 2025 May;44(16):1106-1117
N-Acety-L-Cysteine Alleviates Isoflurane-Triggered Neuronal Cell Parthanatos by Suppressing Reactive Oxygen Species Accumulation Through the Induction of c-Jun N-Terminal Kinase Signaling Pathway Inhibition.
Liu N, Liu Y, Wang X, Liu M, Wang Y, Feng C, Piao M
Journal of biochemical and molecular toxicology 2025 May;39(5):e70268
Journal of biochemical and molecular toxicology 2025 May;39(5):e70268
Macelignan Improves Functional Recovery After Spinal Cord Injury by Augmenting Autophagy via the AKT-mTOR-TFEB Signaling Pathway.
Zhu Y, Yang S, Su S, Huang Y, Chen Y, Liang H, Miao J, Wu Z, Li X, Xiao J, Wang X
Phytotherapy research : PTR 2025 May;39(5):2091-2109
Phytotherapy research : PTR 2025 May;39(5):2091-2109
HDAC6 inhibition upregulates endothelial SOD3 expression via Sp1 acetylation and attenuates angiotensin II-induced hypertension.
Chi Z, Do VQ, Kausar R, Kim HK, Nguyen NTT, Le TPH, Lee J, Baek IJ, Lee SW, Kim JH, Lee SY
The FEBS journal 2025 May;292(10):2624-2644
The FEBS journal 2025 May;292(10):2624-2644
Cardiac PDK4 promotes neutrophilic PFKL methylation and drives the innate immune response in diabetic myocardial infarction.
Yang S, Yan L, Chen L, Su G, Yang L, Gong L, Liu L
Pharmacological research 2025 May;215:107731
Pharmacological research 2025 May;215:107731
UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling.
Lan W, Chen X, Yu H, Ruan J, Kang J, Nie X, Cao Y, Tang S, Ding C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2413709
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2413709
Targeting COPA to Enhance Erdafitinib Sensitivity in FGFR-Altered Bladder Cancer.
Zhao H, Gao X, Jiang Y, Yu Y, Wang L, Sun J, Wang M, Xiong X, Huang C, Zhang H, Jiang G
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(18):e2413209
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(18):e2413209
Tumor cell-intrinsic circular RNA circFNDC3B attenuates CD8(+) T cells infiltration in non-small cell lung cancer.
Wei X, Xiang X, Wang H, Wang Z, Xing S, Peng W, Ye L, Qu Y, Chen L, Yang B, Zhang S, Xue Q, Ai J, Jiang K, Zhou Q
Communications biology 2025 May 8;8(1):711
Communications biology 2025 May 8;8(1):711
Transglutaminase 2 nuclear localization enhances glioblastoma radiation resistance.
Sun C, Du Z, Yang W, Wang Q
Discover oncology 2025 May 30;16(1):952
Discover oncology 2025 May 30;16(1):952
hnRNPL phase separation activates PIK3CB transcription and promotes glycolysis in ovarian cancer.
Qin F, Wang Y, Yang C, Ren Y, Wei Q, Tang Y, Xu J, Wang H, Luo F, Luo Q, Luo X, Liu X, Yang D, Zuo X, Yang Y, Cheng C, Xu J, Wang W, Liu T, Yi P
Nature communications 2025 May 24;16(1):4828
Nature communications 2025 May 24;16(1):4828
Synergistic regulation of DACH1 stability by acetylation and deubiquitination promotes colorectal cancer progression.
Zhu L, Cheng C, Li H, Liu J, Wu Y, Wu L, Yao H
Cell death & disease 2025 May 19;16(1):400
Cell death & disease 2025 May 19;16(1):400
NSUN2-mediated HCV RNA m5C Methylation Facilitates Viral RNA Stability and Replication.
Li ZL, Xie Y, Wang Y, Wang J, Zhou X, Zhang XL
Genomics, proteomics & bioinformatics 2025 May 10;23(1)
Genomics, proteomics & bioinformatics 2025 May 10;23(1)
ZBP1 senses splicing aberration through Z-RNA to promote cell death.
Yang ZH, Wu P, Zhang BX, Yang CR, Huang J, Wu L, Guo SH, Zhou Y, Mao Y, Yin Y, Wu X, Cheng P, Li B, Zhou R, Shen HM, Nie S, Cai ZY, Mo W
Molecular cell 2025 May 1;85(9):1775-1789.e5
Molecular cell 2025 May 1;85(9):1775-1789.e5
Phase separation of MRG15 delays cellular senescence.
Li Y, Jin X, Yu C, Zuo M, Hong L, Wang M, Zhao C, Wu A, Wang J, Ju Z, Wang H
Communications biology 2025 May 1;8(1):688
Communications biology 2025 May 1;8(1):688
The differential impact of HNRNPA1 isoforms on gene expression and their relevance to dsRNA-mediated innate immune response.
Deshaies JE, Triassi V, Lacombe A, Gagné M, Ling K, Ghosh A, Labrecque M, Rigo F, Jafar-Nejad P, Tétreault M, Vande Velde C
Scientific reports 2025 May 1;15(1):15306
Scientific reports 2025 May 1;15(1):15306
Histone demethylase LSD1 promotes castration-resistant prostate cancer by causing widespread gene expression derangements.
Li H, Fan X, Fang X, Wang Y
IUBMB life 2025 Mar;77(3):e70011
IUBMB life 2025 Mar;77(3):e70011
Targeting Hsp90α to inhibit HMGB1-mediated renal inflammation and fibrosis.
Wei H, Ren J, Feng X, Zhao C, Zhang Y, Yuan H, Yang F, Li Q
Cell proliferation 2025 Mar;58(3):e13774
Cell proliferation 2025 Mar;58(3):e13774
Pleiotrophin Prevents H(2)O(2)-Induced Senescence of Dental Pulp Stem Cells.
Liu C, Lei W, Zhang L, Zhang C, Gao R, Jin L
Journal of oral rehabilitation 2025 Mar;52(3):391-400
Journal of oral rehabilitation 2025 Mar;52(3):391-400
ISRIB facilitates post-spinal cord injury recovery through attenuation of neuronal apoptosis and modulation of neuroinflammation.
Li Q, Zhang C, Qi E, Wu M, Sun H, Zhang T, Jiang Y, Li H, Jiang R, Li C, Zhao H, Zhou H, Feng S
Journal of orthopaedic translation 2025 Mar;51:119-131
Journal of orthopaedic translation 2025 Mar;51:119-131
H(2)S Donor SPRC Ameliorates Cardiac Aging by Suppression of JMJD3, a Histone Demethylase.
Li S, Li Q, Xiang H, Wang C, Zhu Q, Ruan D, Zhu YZ, Mao Y
Antioxidants & redox signaling 2025 Mar;42(7-9):301-320
Antioxidants & redox signaling 2025 Mar;42(7-9):301-320
Aldehyde dehydrogenase 2 attenuates renal injury through inhibiting CYP4A expression.
Chen H, Hu Q, Lu Z, Zhao J, Liu A, Liu Z, Luo J, Ye Q, Zhong Z
Translational research : the journal of laboratory and clinical medicine 2025 Mar;277:1-12
Translational research : the journal of laboratory and clinical medicine 2025 Mar;277:1-12
Early intervention with pericyte Fli-1 post-TBI attenuates hippocampal BBB disruption and subsequent neuroinflammation with neurological deficits.
Li J, Du M, Dong G, Hu D, Zhang H, Yu Z, Lu Y, Yang Y
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167671
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167671
Ubiquitin-specific peptidase 10 promotes renal interstitial fibrosis progression through deubiquitinating and stabilizing P53 protein.
Liu S, Yang Y, Li Q, Yu L, Zong Z, Zang R, Ji W, Sun S
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167660
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167660
Tumor exosomal RNPEP promotes lung metastasis of liver cancer via inducing cancer-associated fibroblast activation.
Chen Y, Pan G, Yang Y, Wu H, Weng M, Wu Q, Gao Y, Li W
Cancer science 2025 Mar;116(3):792-807
Cancer science 2025 Mar;116(3):792-807
Neutrophil-derived heparin-binding protein increases endothelial permeability in acute lung injury by promoting TRIM21 and the ubiquitination of P65.
Zhang J, Cao Y, Shu W, Dong S, Sun Y, Ma X
Cell biology and toxicology 2025 Mar 5;41(1):55
Cell biology and toxicology 2025 Mar 5;41(1):55
Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness.
Cui B, Luo H, He B, Liu X, Lv D, Zhang X, Su K, Zheng S, Lu J, Wang C, Yang Y, Zhao Z, Liu X, Wang X, Zhao Y, Nie X, Jiang Y, Zhang Z, Liu C, Chen X, Cai A, Lv Z, Liu Z, An F, Zhang Y, Yan Q, Kelley KW, Xu G, Xu L, Liu Q, Peng F
Signal transduction and targeted therapy 2025 Mar 5;10(1):79
Signal transduction and targeted therapy 2025 Mar 5;10(1):79
Photoinduced Actin Aggregation Involves Cell Death: A Mechanism of Cancer Cell Cytotoxicity after Near-Infrared Photoimmunotherapy.
Sato K, Okada T, Okada R, Yasui H, Yamada M, Isobe Y, Nishinaga Y, Shimizu M, Koike C, Fukushima R, Takahashi K, Taki S, Kato A, Sato M, Ogura T
ACS nano 2025 Mar 4;19(8):8338-8356
ACS nano 2025 Mar 4;19(8):8338-8356
BRD4 Mediates Cadmium-Induced Oxidative Stress and Kidney Injury in Mice via Disruption of Redox Homeostasis.
Chen J, Guo G, Wang X, Li Z, Ji T, Li Y, Dong H, Zhang H, Gao M
Toxics 2025 Mar 29;13(4)
Toxics 2025 Mar 29;13(4)
20-hydroxyecdysone via upregulating 4EBP expression and inhibiting its phosphorylation represses cell proliferation to permit insect larval molting.
Wang XP, Ye MZ, Tu WT, Zhao XF
Insect science 2025 Mar 26;
Insect science 2025 Mar 26;
Baicalein Ameliorates Experimental Ulcerative Colitis Recurrency by Downregulating Neonatal Fc Receptor via the NF-κB Signaling Pathway.
Hu H, Lu F, Guan X, Jiang X, Wen C, Wang L
ACS omega 2025 Mar 18;10(10):10701-10712
ACS omega 2025 Mar 18;10(10):10701-10712
Mechanism of ASF1 engagement by CDAN1.
Sedor SF, Shao S
Nature communications 2025 Mar 16;16(1):2599
Nature communications 2025 Mar 16;16(1):2599
Neuroprotective effect of apo-9'-fucoxanthinone against cerebral ischemia injury by targeting the PI3K/AKT/GSK-3β pathway.
Qi Y, Tang S, Jin S, Wang J, Zhang Y, Xu X, Zhu H, Zhang J, Xu X, Zhao M, Zhu H, Yan P
European journal of pharmacology 2025 Mar 15;991:177348
European journal of pharmacology 2025 Mar 15;991:177348
NNMT promotes acquired EGFR-TKI resistance by forming EGR1 and lactate-mediated double positive feedback loops in non-small cell lung cancer.
Dai J, Lu X, Zhang C, Qu T, Li W, Su J, Guo R, Yin D, Wu P, Han L, Zhang E
Molecular cancer 2025 Mar 15;24(1):79
Molecular cancer 2025 Mar 15;24(1):79
iPSC-derived cardiomyocytes and engineered heart tissues reveal suppressed JAK2/STAT3 signaling in LMNA-related emery-dreifuss muscular dystrophy.
Fan H, Yang Z, Ying H, Zhao J, Wang X, Gong J, Li L, Liu X, Gong T, Ke Q, Zhuang L, Liang P
Redox biology 2025 Jun;83:103638
Redox biology 2025 Jun;83:103638
Tyrosine and Phenylalanine Activate Neuronal DNA Repair but Exhibit Opposing Effects on Global Transcription and Adult Female Mice Are Resilient to TyrRS/YARS1 Depletion.
Jhanji M, Bhan A, Arrowood C, Yakout DW, Shroff A, McManus D, Gifford H, Vacharasin J, Lizarraga SB, Nazarko TY, Mabb AM, Sajish M
IUBMB life 2025 Jun;77(6):e70030
IUBMB life 2025 Jun;77(6):e70030
Tryptophan Metabolic Enzyme IL4I1 Inhibits Ferroptosis by Decreasing Ubiquitination of Nrf2 via I3P in Glioblastoma.
Xu Y, Hong Y, Yan T, Sun Q, Yuan F, Liang S, Ye L, Geng R, Qi Y, Ye Q, Chen Q
Cell proliferation 2025 Jun;58(6):e13816
Cell proliferation 2025 Jun;58(6):e13816
5-HT(7)R Deficiency Alleviates ADP-Heptose-Induced Cognitive Impairment via Inhibiting Ferroptosis and Neuroinflammation in Mice.
Zou X, Yang YX, Yue BJ, Yang HY, Yang YR, Li MY, Du O, Qiao G, Wu YJ, Du JR, Long FY
CNS neuroscience & therapeutics 2025 Jun;31(6):e70455
CNS neuroscience & therapeutics 2025 Jun;31(6):e70455
CuATSM Enhances Wound Repair Without Scarring via Hippo/YAP Signalling Pathway to Reduce Ferroptosis and Macrophage Polarisation.
Tang Y, Ye J, Xu T, Sun Y, Meng W, Zhu L, Jia Z, Wu Q, Chen D, Wu F
Journal of cellular and molecular medicine 2025 Jun;29(12):e70590
Journal of cellular and molecular medicine 2025 Jun;29(12):e70590
Rotenone adaptation promotes migration and invasion of p53-wild-type colon cancer through lipid metabolism.
Shi Y, Cao Z, Ge L, Lei L, Tao D, Zhong J, Xu D, Geng T, Li X, Li Z, Xing S, Wu X, Wang Z, Li L
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2025 Jun;27(6):2557-2567
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2025 Jun;27(6):2557-2567
Spatial alteration of metabolites in diabetic cortical cataracts: New insight into lactate.
Li P, Wu M, Wang R, Zhang G, Kang L, Guan H, Ji M
Experimental eye research 2025 Jun;255:110361
Experimental eye research 2025 Jun;255:110361
Glabridin ameliorates hemorrhagic shock induced acute kidney injury by activating Nrf2/HO-1 pathway.
Shu L, Zhang Z, Wang N, Yin Q, Chao Y, Ge X
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167810
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167810
Neferine reduces synovial inflammation and cardiac complications in a collagen-induced arthritis mouse model via inhibiting NF-κB/NLRP3 inflammasome axis.
Cao J, Zhang H, Ni Y, Ning X
Molecular immunology 2025 Jun;182:117-125
Molecular immunology 2025 Jun;182:117-125
OsPPR8, a pentatricopeptide repeat protein, regulates splicing of mitochondrial nad2 intron 3 to affect grain quality and high-temperature tolerance in rice.
Yuan H, Zeng J, Xu Z, Yuan M, Zhou X, Liu Y, Yan X, Diao X, Gong S, Yang F, Hu X, Zhong Y, Huang L, Wang H, Chen W, Tu B, Li T, Xiong J, Zhong Z, Wang Y, Ma B, Li S, Qin P
The Plant journal : for cell and molecular biology 2025 Jun;122(5):e70246
The Plant journal : for cell and molecular biology 2025 Jun;122(5):e70246
Mitochondrial oxidative stress inhibited Sirt3/Foxo3/PPARα pathway and aggravated copper and zinc co-deficiency-induced hepatic lipotoxicity in a fish model.
Zhong CC, Zhang X, Pantopoulos K, Song CC, Yang H, Wei XL, Luo Z
Cellular and molecular life sciences : CMLS 2025 Jun 5;82(1):226
Cellular and molecular life sciences : CMLS 2025 Jun 5;82(1):226
Elevated phenylacetylglutamine caused by gut dysbiosis associated with type 2 diabetes increases neutrophil extracellular traps formation and exacerbates brain infarction.
Wei M, Huang Q, Yu F, Luo YF, Feng X, Liao D, Li J, Zhang B, Liu ZY, Xia J
Clinical science (London, England : 1979) 2025 Jun 5;139(12):717-36
Clinical science (London, England : 1979) 2025 Jun 5;139(12):717-36
O-GlcNAcylation-mediated endothelial metabolic memory contributes to cardiac damage via small extracellular vesicles.
Ding M, Shi R, Du Y, Chang P, Gao T, De D, Chen Y, Li M, Li J, Li K, Cheng S, Gu X, Li J, Zhang S, Feng N, Liu J, Jia M, Fan R, Pei J, Gao C, Fu F
Cell metabolism 2025 Jun 3;37(6):1344-1363.e6
Cell metabolism 2025 Jun 3;37(6):1344-1363.e6
Reduced NRF2/Mfn2 activity promotes endoplasmic reticulum stress and senescence in adipose-derived mesenchymal stem cells in hypertrophic obese mice.
Fang J
World journal of stem cells 2025 Jun 26;17(6):104367
World journal of stem cells 2025 Jun 26;17(6):104367
Targeting the SP/KLF Transcriptional Regulatory Network Synergizes with HDAC Inhibition to Impede Progression of H3K27M Diffuse Intrinsic Pontine Glioma.
Kong Y, Wang F, Jing R, Zhao Q, Lv X, Zhao Y, Yuan Y, Xia X, Sun Y, Tong Y, Yan H, Li Q, Li T, Cao L, Liu D, Huo D, Sun SK, Morís F, Tang Y, Wu X
Cancer research 2025 Jun 2;85(11):2100-2116
Cancer research 2025 Jun 2;85(11):2100-2116
Inhibition of NR2F2 Attenuates Vascular Dysfunction in Diabetic Retinopathy by Alleviating Endoplasmic Reticulum Stress in Retinal Microvascular Endothelial Cells.
Zhang T, Yang Q, Chen J, Jiang J, Han J, Zhou Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70667
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70667
ATP7A Maintains Bactericidal Function of Neutrophils and Macrophages via Regulating the Formation and Activation of Phagolysosomes.
Jing Y, Shi J, Xie Z, Shen Z, Zhang J, Wang F, Li K, Su J, Liu JX
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70661
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70661
KLF4 mediates the contradictory effects of phenylethyl isothiocyanate in gastric cancer intervention.
Zhang Q, Yang C, Zhou B, Gao X, Zhong C, Shi Y, Cao H, Zhu M
Medical oncology (Northwood, London, England) 2025 Jun 12;42(7):253
Medical oncology (Northwood, London, England) 2025 Jun 12;42(7):253
Targeting NAT10 attenuates homologous recombination via destabilizing DNA:RNA hybrids and overcomes PARP inhibitor resistance in cancers.
Xu Z, Zhu M, Geng L, Zhang J, Xia J, Wang Q, An H, Xia A, Yu Y, Liu S, Tong J, Zhu WG, Jiang Y, Sun B
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2025 Jul;81:101241
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2025 Jul;81:101241
Changes in adrenoceptor expression level contribute to the cellular plasticity of glioblastoma cells.
Asaka Y, Masumoto T, Uneda A, Chin VD, Otani Y, Peña T, Katayama H, Itano T, Ando T, Huang R, Fujimura A
The journal of physiological sciences : JPS 2025 Jul;75(2):100016
The journal of physiological sciences : JPS 2025 Jul;75(2):100016
Testis-Specific PDHA2 Is Required for Proper Meiotic Recombination and Chromosome Organisation During Spermatogenesis.
Wang G, Fang K, Shang Y, Zhou X, Shao Q, Li S, Wang P, Chen CD, Zhang L, Wang S
Cell proliferation 2025 Jul;58(7):e70003
Cell proliferation 2025 Jul;58(7):e70003
The Trim32-DPEP2 axis is an inflammatory switch in macrophages during intestinal inflammation.
Zhan Z, Liang H, Zhao Z, Pan L, Li J, Chen Y, Xie Z, Yan Z, Xiang Y, Liu W, Hong L
Cell death and differentiation 2025 Jul;32(7):1336-1352
Cell death and differentiation 2025 Jul;32(7):1336-1352
Coriander-Derived Exosome-Like Nanovesicles Laden Hydrogel with Antioxidant Property Accelerates Wound Healing.
Wang T, Li Y, Hao L, Liu Y, Liu D, Zhang C, Yi H, Zhang J
Macromolecular bioscience 2025 Jul;25(7):e2400640
Macromolecular bioscience 2025 Jul;25(7):e2400640
Identification of cytochrome P450 2E1 as a novel target in neuroinflammation and development of its inhibitor Q11 as a treatment strategy.
Yang R, Deng MY, Yang LK, Wang GZ, Ma J, Wen Q, Gao N, Qiao HL
Free radical biology & medicine 2025 Jul;234:220-232
Free radical biology & medicine 2025 Jul;234:220-232
SARS-CoV-2 encoded ORF3a interacts with YY1 to promote latent HCMV reactivation.
Xia S, Huo X, Liu N, Liu X, Wang T, Guo M, Zeng C, Wan P, Chen J
PLoS pathogens 2025 Jul;21(7):e1013344
PLoS pathogens 2025 Jul;21(7):e1013344
Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration.
Tang Q, Tang K, Markby GR, Parys M, Phadwal K, MacRae VE, Corcoran BM
Autophagy 2025 Jul;21(7):1433-1455
Autophagy 2025 Jul;21(7):1433-1455
FTO-mediated m(6)A demethylation regulates IGFBP3 expression and AKT activation through IMP3-dependent P-body re-localisation in lung cancer.
Wang H, Peng H, Zhang Z, Abulimiti Y, Hu J, Zhou Y, Ji P, Li D
Clinical and translational medicine 2025 Jul;15(7):e70392
Clinical and translational medicine 2025 Jul;15(7):e70392
Neuronal FGF13 Inhibits Mitochondria-Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease.
Song N, Wang X, Ha L, Hu L, Mei S, Liang Y, Zhao Y, Yang X, Zhang Q, Zhou Y, Ding J, Liu Y, Zhou Q, Han F, Hu G, Lu M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(28):e2503579
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(28):e2503579
Role of PRC2 in the stochastic expression of Aire target genes and development of mimetic cells in the thymus.
Matsumoto M, Yoshida M, Oya T, Tsuneyama K, Matsumoto M, Yoshida H
The Journal of experimental medicine 2025 Jul 7;222(7)
The Journal of experimental medicine 2025 Jul 7;222(7)
Cardiac-specific overexpression of PRMT5 exacerbates pressure overload-induced hypertrophy and heart failure.
Katanasaka Y, Sunagawa Y, Sakurai R, Tojima M, Naruta R, Hojo Y, Kawase Y, Hamabe-Horiike T, Mori K, Hasegawa K, Morimoto T
Journal of biomedical science 2025 Jul 6;32(1):61
Journal of biomedical science 2025 Jul 6;32(1):61
Cancer cell type-specific derepression of transposable elements by inhibition of chromatin modifier enzymes.
Patel D, Tiusanen V, Karttunen K, Pihlajamaa P, Sahu B
Communications biology 2025 Jul 3;8(1):992
Communications biology 2025 Jul 3;8(1):992
Targeted degradation of sICOSL reverses cytotoxic T cells dysfunction.
Wu Z, Zheng P, Qi R, Xiao Y, Xi Z, Dai L, Chen T, Wang Q, Zhang F, Wang R, Tang Z, Zhao X, Tan J, Ming J, Lei P, Liu C, Huang T
Experimental hematology & oncology 2025 Jul 24;14(1):100
Experimental hematology & oncology 2025 Jul 24;14(1):100
Nuclear Lactate Dehydrogenase A Resists Cardiomyocyte Cell Cycle Arrest Induced by Oxidative Stress.
Cao M, Luo J, Fu K, Xu Y, Wang Y, Duan J, Chen R, Yuan W
Journal of cardiovascular development and disease 2025 Jul 21;12(7)
Journal of cardiovascular development and disease 2025 Jul 21;12(7)
Regulation of Mitochondrial Metabolism by Mfn1 Gene Encoding Mitofusin Affects Cellular Proliferation and Histone Modification.
Xu H, Zhao X, Yun Y, Gao Y, Bo C, Song L, Bai C, Yang L, Li G, Su G
Cells 2025 Jul 2;14(13)
Cells 2025 Jul 2;14(13)
Genome-wide CRISPR/Cas9 screening identifies PTGR2 as a potential therapeutic target for sunitinib resistance in clear cell renal cell carcinoma.
Chang W, Zhang B, Yang S, Zhang X, Zhang L, Zhang S, Lu J, Wang W, Shang P, Yue Z
Scientific reports 2025 Jul 19;15(1):26263
Scientific reports 2025 Jul 19;15(1):26263
Altered cofactor recruitment and nucleosome dynamics underlie bisphenol A's impact on ERα-mediated transcriptional bursting.
Day CR, Yaşar P, Adedoyin G, Bennett BD, Chow CC, Rodriguez J
iScience 2025 Jul 18;28(7):112864
iScience 2025 Jul 18;28(7):112864
KLF5-regulated ZDHHC8 reduces chemosensitivity in high-grade serous ovarian cancer through β-catenin signaling.
Xue Z, Li X, Zhou W, Teng Y
Scientific reports 2025 Jul 18;15(1):26176
Scientific reports 2025 Jul 18;15(1):26176
DHX9-mediated epigenetic silencing of BECN1 contributes to impaired autophagy and tumor progression in breast cancer via recruitment of HDAC5.
Li Z, Liu F, Li F, Zeng G, Wen X, Ding J, Zhou J
Cell death & disease 2025 Jul 14;16(1):524
Cell death & disease 2025 Jul 14;16(1):524
Bifidobacterium animalis subsp. Lactis BX-BC08 modulates gut microbiota and secretes alpha-Ketoglutaric acid to alleviate MC903-induced atopic dermatitis.
Zhao J, Kui L, Huang J, Deng J, Liu L, Zhu C, Shi Y, Li C, Xiao Y, Yu J, Li Q, Yang B, Leng B, Chan H
Journal of translational medicine 2025 Jul 10;23(1):768
Journal of translational medicine 2025 Jul 10;23(1):768
ACSS2 protects against alcohol-induced hepatocyte ferroptosis through regulation of hepcidin expression.
Wang M, Wen X, Feng Z, Choubey M, Chen S, Pan R, Gong K, Tirumalasetty MB, Gao F, Liao C, Yin Z, Zhang S, He Y, Chen H, Cao Y, Miao QR, Hu W, Duan Y
Nature communications 2025 Jul 1;16(1):5491
Nature communications 2025 Jul 1;16(1):5491
3-Oxo-11αH-germacra-1(10) E,4Z-dien-12,6α-olide, a sesquiterpene from Artemisia sieversiana, attenuates lipopolysaccharide-induced inflammation via NF-κB/MAPK pathways and oxidative stress via ROS pathway in RAW264.7 cells.
Ren Q, Wang L, Wang X, Min X, Dai X, Huang G, Cao J
Journal of natural medicines 2025 Jan;79(1):204-214
Journal of natural medicines 2025 Jan;79(1):204-214
The steroid hormone 20-hydroxyecdysone inhibits RAPTOR expression by repressing Hox gene transcription to induce autophagy.
Liu TW, Tian C, Li YX, Wang JX, Zhao XF
The Journal of biological chemistry 2025 Jan;301(1):108093
The Journal of biological chemistry 2025 Jan;301(1):108093
The translation initiation factor eIF2α regulates lipid homeostasis and metabolic aging.
Huang H, Liao Y, Li N, Qu X, Li C, Hou J
Aging cell 2025 Jan;24(1):e14348
Aging cell 2025 Jan;24(1):e14348
Manganese is a potent inducer of lysosomal activity that inhibits de novo HBV infection.
Yu L, Chang H, Xie W, Zheng Y, Yang L, Wu Q, Bu F, Zhu Y, Xie Y, Pan G, Lan K, Deng Q
PLoS pathogens 2025 Jan;21(1):e1012800
PLoS pathogens 2025 Jan;21(1):e1012800
PIEZO1 mediates matrix stiffness-induced tumor progression in kidney renal clear cell carcinoma by activating the Ca(2+)/Calpain/YAP pathway.
Zhu B, Li F, Yu J, Liang Z, Ke X, Wang Y, Song Z, Li Z, Li G, Guo Y
Biochimica et biophysica acta. Molecular cell research 2025 Jan;1872(1):119871
Biochimica et biophysica acta. Molecular cell research 2025 Jan;1872(1):119871
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway.
Duah M, Zheng F, Shen J, Xu Y, Cao S, Yan Z, Lan Q, Wang Y, Xu K, Pan B
Acta pharmaceutica Sinica. B 2025 Jan;15(1):224-238
Acta pharmaceutica Sinica. B 2025 Jan;15(1):224-238
Impaired Iron-Sulfur Cluster Synthesis Induces Mitochondrial PARthanatos in Diabetic Cardiomyopathy.
Wang M, Zhang S, Tian J, Yang F, Chen H, Bai S, Kang J, Pang K, Huang J, Dong M, Dong S, Tian Z, Fang S, Fan H, Lu F, Yu B, Li S, Zhang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(1):e2406695
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(1):e2406695
Long non-coding RNA LINC01224 plays an oncogenic role in endometrial cancer via miR-4673/TPX2 axis and activating Wnt/β-catenin signaling pathway.
Lv S, Zhang X, Lang F, Wu Y, Zhang C, Qi Q, Jiang J
BioFactors (Oxford, England) 2025 Jan-Feb;51(1):e2153
BioFactors (Oxford, England) 2025 Jan-Feb;51(1):e2153
Inhibition of mTOR/S6K1/Gli1 signaling alleviates morphine-induced thermal hyperalgesia and tolerance.
Wang XH, Wang L, Yang L, Bai Y, Xu LF, Li MM, Liu YC, Sun J, Liu S
Molecular pain 2025 Jan-Dec;21:17448069251376198
Molecular pain 2025 Jan-Dec;21:17448069251376198
Transplantation of engineered endothelial progenitor cells with H19 overexpression promotes arterial reendothelialization and inhibits neointimal hyperplasia.
Ye Y, Huang L, Wang K, Sun Y, Zhou Z, Deng T, Liu Y, Wang R, Wu R, Yao C
Journal of tissue engineering 2025 Jan-Dec;16:20417314251315959
Journal of tissue engineering 2025 Jan-Dec;16:20417314251315959
SIX1 aggravates the progression of spinal cord injury in mice by promoting M1 polarization of microglia.
Xu Z, Zhu M, Xie H, Zhu J, Zheng H, Liu X, Zhang Y, Liu J
Scientific reports 2025 Jan 8;15(1):1283
Scientific reports 2025 Jan 8;15(1):1283
Modulation of Abnormal Vasoconstriction Through 2-Hydroxyisobutyrylation of Tropomyosin 3 Lys141: Targeting Histone Deacetylase 3 as a Key Approach.
Pang PP, Liu JX, Su WB, Gao WC, Qiao GR, Yuan J, Zheng YT, Zheng CB
Journal of the American Heart Association 2025 Jan 7;14(1):e037400
Journal of the American Heart Association 2025 Jan 7;14(1):e037400
The cholesterol metabolite 25-hydroxycholesterol suppresses porcine deltacoronavirus via lipophagy inhibition and mTORC1 modulation.
Zhang JL, Wang XF, Li JL, Duan C, Wang JF
Veterinary research 2025 Jan 31;56(1):23
Veterinary research 2025 Jan 31;56(1):23
Cordycepin Extracted from Cordyceps militaris mitigated CUMS-induced depression of rats via targeting GSK3β/β-catenin signaling pathway.
Wang Y, Deng Y, Feng M, Chen J, Zhong M, Han Z, Zhang Q, Sun Y
Journal of ethnopharmacology 2025 Jan 31;340:119249
Journal of ethnopharmacology 2025 Jan 31;340:119249
Multi-platform analysis revealed the substance basis and mechanism of Wei-Tong-Xin in ameliorating ENS dysfunction for dyspepsia treatment.
Zhang X, Wang S, Xie J, Wang J, Gu Y, Wu B, Zhang Y, Yan T, Jia Y
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118875
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118875
Anionic polymer coating for enhanced delivery of Cas9 mRNA and sgRNA nanoplexes.
Chen S, Pinto Carneiro S, Merkel OM
Biomaterials science 2025 Jan 28;13(3):659-676
Biomaterials science 2025 Jan 28;13(3):659-676
SPHK1 enhances olaparib resistance in ovarian cancer through the NFκB/NRF2/ferroptosis pathway.
Teng K, Ma H, Gai P, Zhao X, Qi G
Cell death discovery 2025 Jan 28;11(1):29
Cell death discovery 2025 Jan 28;11(1):29
ADSCs-derived exosomes suppress macrophage ferroptosis via the SIRT1/NRF2 signaling axis to alleviate acute lung injury in sepsis.
Bai X, Liu Y, Liu J, Guo K, Guan H
International immunopharmacology 2025 Jan 27;146:113914
International immunopharmacology 2025 Jan 27;146:113914
Apaf-1 is an evolutionarily conserved DNA sensor that switches the cell fate between apoptosis and inflammation.
Ruan J, Wei X, Li S, Ye Z, Hu L, Zhuang R, Cao Y, Wang S, Wu S, Peng D, Chen S, Yuan S, Xu A
Cell discovery 2025 Jan 21;11(1):4
Cell discovery 2025 Jan 21;11(1):4
MARTRE family proteins negatively regulate CCR4-NOT activity to protect poly(A) tail length and promote translation of maternal mRNA.
Yang J, Bu J, Liu B, Liu Y, Zhang Z, Li Z, Lu F, Zhu B, Li Y
Nature communications 2025 Jan 2;16(1):248
Nature communications 2025 Jan 2;16(1):248
Loss of YTHDC1 m(6)A reading function promotes invasiveness in urothelial carcinoma of the bladder.
Xu J, Koch J, Schmidt C, Nientiedt M, Neuberger M, Erben P, Michel MS, Rodríguez-Paredes M, Lyko F
Experimental & molecular medicine 2025 Feb;57(1):118-130
Experimental & molecular medicine 2025 Feb;57(1):118-130
1,25(OH)(2)D(3) induces chondrocyte autophagy and reduces the loss of proteoglycans in osteoarthritis through inhibiting the NF-κB pathway.
Liu P, Zhou J, Cui H, Xu J, Ruan G, Ding C, Wang K
Clinical rheumatology 2025 Feb;44(2):811-822
Clinical rheumatology 2025 Feb;44(2):811-822
Organophosphate flame retardant triphenyl phosphate (TPhP) induced colonic fibrosis by bringing about epithelial-mesenchymal transition.
Peng C, Wang M, Zheng C, Zhang X, Chen Y, Wang L
Ecotoxicology and environmental safety 2025 Feb;291:117913
Ecotoxicology and environmental safety 2025 Feb;291:117913
Melittin suppresses ovarian cancer growth by regulating SREBP1-mediated lipid metabolism.
Wu R, Li N, Huang W, Yang Y, Zang R, Song H, Shi J, Zhu S, Liu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Feb;137:156367
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Feb;137:156367
PNPO-Mediated Oxidation of DVL3 Promotes Multiple Myeloma Malignancy and Osteoclastogenesis by Activating the Wnt/β-Catenin Pathway.
Deng Z, Sun S, Zhou N, Peng Y, Cheng L, Yu X, Yuan Y, Guo M, Xu M, Cheng Y, Zhou F, Li N, Yang Y, Gu C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2407681
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2407681
Mono-ubiquitination of TopBP1 by PHRF1 enhances ATR activation and genomic stability.
Zhao F, Cai C, Gao H, Moon J, Christyani G, Qin S, Hao Y, Liu T, Lou Z, Kim W
Nucleic acids research 2025 Feb 27;53(5)
Nucleic acids research 2025 Feb 27;53(5)
Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3.
Ye L, Shen S, Mao Q, Lu H, Liu H, Zhang P, Jiang Z, Ma W, Sun Y, Chu Y, Zhou Z, Liu R, Li J, Li ST, Gao P, Zhang H
Cell reports 2025 Feb 25;44(2):115250
Cell reports 2025 Feb 25;44(2):115250
Targeted temperature management alleviates post-resuscitation myocardial dysfunction by inhibiting ferroptosis.
Zhang Y, Du W, Kong T, Hua T, Ma H, Hu Y, Pan S, Ling B, Yang M, Cheng C
Cell death discovery 2025 Feb 21;11(1):71
Cell death discovery 2025 Feb 21;11(1):71
Targeting p38 MAPK signaling pathway and neutrophil extracellular traps: An important anti-inflammatory mechanism of Huangqin Qingre Chubi Capsule in rheumatoid arthritis.
Li Y, Liu J, Sun Y, Hu Y, Cong C, Chen Y, Fang Y
International immunopharmacology 2025 Feb 20;148:114112
International immunopharmacology 2025 Feb 20;148:114112
NINJ1-mediated plasma membrane rupture of pyroptotic endothelial cells exacerbates blood-brain barrier destruction caused by neutrophil extracellular traps in traumatic brain injury.
Zheng XB, Wang X, Gao SQ, Gao CC, Li T, Han YL, Zhao R, Sun Y, Miao SH, Qiu JY, Jin WX, Zhou ML
Cell death discovery 2025 Feb 20;11(1):69
Cell death discovery 2025 Feb 20;11(1):69
A glucose-enriched lung pre-metastatic niche triggered by matrix stiffness-tuned exosomal miRNAs in hepatocellular carcinoma.
Zhao Y, Yu H, Li J, Qian J, Li M, Zhang X, Wang M, Wang Y, Dong Y, You Y, Zhou Q, Gao D, Zhao Y, Liu B, Chen R, Ren Z, Wang Z, Zhang K, Cui J
Nature communications 2025 Feb 18;16(1):1736
Nature communications 2025 Feb 18;16(1):1736
PBX1 attenuates inflammation and apoptosis of trophoblast cells induced by LPS through downregulating the transcription of TMUB1: PBX1 ameliorates RSA development.
Zhang X, Wang S, Liang L, Hu F, Zhang X, Cui X, Zhang Z, Wu X
Journal of molecular histology 2025 Feb 17;56(2):91
Journal of molecular histology 2025 Feb 17;56(2):91
GLS1-mediated glutamine metabolism mitigates oxidative stress-induced matrix degradation, ferroptosis, and senescence in nucleus pulposus cells by modulating Fe(2+) homeostasis.
Wu J, Qin T, Han W, Zhang C, Zhang X, Huang Z, Wu Y, Xu Y, Xu K, Ye W
Free radical biology & medicine 2025 Feb 16;228:93-107
Free radical biology & medicine 2025 Feb 16;228:93-107
Role of the NuRD complex and altered proteostasis in cancer cell quiescence.
Jiang Q, Ertel M, Arrigo A, Sannino S, Goeckeler-Fried JL, Sagan A, Varghese BA, Brown DD, Stallaert W, Lee A, Clark AM, Brodsky JL, Osmanbeyoglu HU, Buckanovich RJ
bioRxiv : the preprint server for biology 2025 Feb 14;
bioRxiv : the preprint server for biology 2025 Feb 14;
Mettl3/Eed/Ythdc1 regulatory axis controls endometrial receptivity and function.
Hu X, Li J, Ding C, Jiang J, Xia W, Lu J, Su H, Zhang M, Li H, Liu JL, Lin Y, Meng Q, Huang B
Communications biology 2025 Feb 11;8(1):215
Communications biology 2025 Feb 11;8(1):215
SIRT6 inhibits endoplasmic reticulum stress-mediated ferroptosis by activating Nrf2/HO-1 signaling to alleviate osteoarthritis.
Shi J, Chen L, Wang X, Ma X
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Feb 10;74(1):35
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Feb 10;74(1):35
WWP2 Overexpression Represses NLRP3 Inflammasome Activation in Cerebral Ischemia/Reperfusion Injury Through the Degradation of MAVS.
Yu H, Li J, Lu T, Dai M, Wan X
Glia 2025 Dec;73(12):2445-2463
Glia 2025 Dec;73(12):2445-2463
AKR1B1 is Required for Maintaining Acute Leukemia Cell Survival by Epigenetic Silencing of Tumor Suppressor Genes.
Chen J, Xu L, Li W, Sun M, Chen Y, Qiu T, Wu Y, Lv X, Liu F, Fan H
Biochemical genetics 2025 Dec;63(6):5273-5293
Biochemical genetics 2025 Dec;63(6):5273-5293
Higenamine Hydrochloride Attenuates Neuroinflammation in Type I Diabetic Mice by Inhibiting the CRTC2-CREB Signaling Pathway via PAK4.
Li Y, Wang L, Cao Y, Lu H, Zhou J, Zhao P, Guan X, Dong Z
Molecular neurobiology 2025 Dec;62(12):16636-16658
Molecular neurobiology 2025 Dec;62(12):16636-16658
Pharmacological Activation of GPR68 Attenuates Ferroptosis in Spinal Cord Ischemia/Reperfusion Injury Through PI3K/Akt-Mediated Nrf2 Antioxidant Pathway.
Yang R, Ye J, Wang P, Liu T, Cheng B, Li F
Inflammation 2025 Dec;48(6):4289-4301
Inflammation 2025 Dec;48(6):4289-4301
RAB3A-mediated BAG6 translocation promotes non-small cell lung cancer tumorigenesis and progression.
Liu X, Wang W, Cao W, Li Z, Huang H, Liu F, Wang Y, Zhong Z, Zhang H, Pei X, Chen H
Cellular oncology (Dordrecht, Netherlands) 2025 Dec;48(6):2001-2015
Cellular oncology (Dordrecht, Netherlands) 2025 Dec;48(6):2001-2015
Tanshinone IIA alleviates LPS-induced acute kidney injury by inhibiting RIP3/Nrf2-mediated oxidative stress.
Zhang S, Dong X, Chen G, Wang C
Renal failure 2025 Dec;47(1):2593719
Renal failure 2025 Dec;47(1):2593719
Hypoxia-induced MT2A-tetrameric PKM2 interaction maintains PKM2 activity in a copper-ion-dependent manner.
Gao R, Li Q, Guo J, Peng Z, Gao C, Zhou Z, Hu H, Zhang J
Cell insight 2025 Dec;4(6):100277
Cell insight 2025 Dec;4(6):100277
CircRAB23 functions as miR-532-3p sponge to promote the malignant proliferation and metastasis of intrahepatic cholangiocarcinoma through HMGA2-EMT axis.
Zhang K, Chen J, Shen S, Zhang H, Xia J, Zhao Y, Yang P, Yan X, Liu C, Ge R, Wang N, Yang X
International journal of biological macromolecules 2025 Dec;332(Pt 2):148685
International journal of biological macromolecules 2025 Dec;332(Pt 2):148685
Apelin-13 Attenuates Blood-Brain Barrier Dysfunction Following Intracerebral Hemorrhage via Targeting the Keap1/Nrf2 Signaling.
Guo P, Siddique R, Qian J, Qi L, Yong VW, Xue M
CNS neuroscience & therapeutics 2025 Dec;31(12):e70706
CNS neuroscience & therapeutics 2025 Dec;31(12):e70706
TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD.
Joseph BJ, Marshall KA, Harley P, Mann JR, Alessandrini F, Vanoye CG, Chi W, Prudencio M, Simkin D, Kao TT, Desai RR, Keuss MJ, Barattucci S, Zanovello M, Mehta PR, DeKeyser JM, Limone F, Lee J, Brown AL, Leyton-Jaimes MF, Nash LA, Juan IGS, Aronica E, Wainger BJ, Shah M, Goswami A, Shneider NA, Dickson DW, Burrone J, Zhang C, Wichterle H, Petrucelli L, Watts JK, George AL Jr, Fratta P, Eggan K, Kiskinis E
Nature neuroscience 2025 Dec;28(12):2476-2492
Nature neuroscience 2025 Dec;28(12):2476-2492
WDR4 drives tumour-associated macrophage reprogramming and tumour progression via selective translation and membrane cholesterol efflux.
Liu J, Qu C, Liu Y, Gongye X, Zhang M, Ma T, He W, Wang H, Chen X, Xia P, Yuan Y
Nature cell biology 2025 Dec;27(12):2152-2166
Nature cell biology 2025 Dec;27(12):2152-2166
Pseudorabies virus gM protein and herpesvirus homologs block selective autophagy to enhance viral replication.
Zhou Q, Shi D, Tang YD, Zhang L, Liu H, Ye G, Zhang Z, Hu B, Huang L, Weng C
Autophagy 2025 Dec;21(12):2597-2613
Autophagy 2025 Dec;21(12):2597-2613
COL4A2 drives ECM remodeling and stiffness increasing to promote breast cancer metastasis via YAP signaling pathway in dECM induced models.
Peng J, Zhu W, Zhang C, Yin S, Ye J, Mao H, Li M, Zhao J
Biomaterials advances 2025 Dec;177:214430
Biomaterials advances 2025 Dec;177:214430
Naringenin boosts Parkin-mediated mitophagy via estrogen receptor alpha to maintain mitochondrial quality control and heal diabetic foot ulcer.
Zhou XM, Yang Y, Yu DJ, Xie T, Sun XL, Han YX, Tian HY, Liao QQ, Zhao YJ, Liou YC, Huang W, Xu Y, Kuang X, Sun XD, Zhang YY
Journal of pharmaceutical analysis 2025 Dec;15(12):101333
Journal of pharmaceutical analysis 2025 Dec;15(12):101333
A novel HDAC1-specific inhibitor prevents estrogen deficiency-induced osteoporosis in mice by inhibiting osteoclast function.
Yuan H, Bao Y, Li L, Luan Y, Li F
Archives of gerontology and geriatrics 2025 Dec;139:106020
Archives of gerontology and geriatrics 2025 Dec;139:106020
YAP regulates the hypertrophy and apoptosis of antler chondrocytes through maintaining calcium homeostasis and mitochondrial function.
Li BY, Yang ZQ, Xing YF, Zhang QL, Wang CH, Yue ZP, Guo B
Cellular signalling 2025 Dec;136:112137
Cellular signalling 2025 Dec;136:112137
Aloe-Emodin Targeting FOXC2 Disrupts NETs Formation and EMT-Driven Postoperative Peritoneal Adhesion Through TGF-β1-Smad2/3 Pathway.
Yang L, Fang Y, Lian Y, Kong Z, Miao J, Chen Y, Li W, Chen F, Zhang B, Chen Y, Bian Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(48):e11013
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(48):e11013
Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR-NFκB Pathway.
Chen J, Liu N, Tao Q, Wu J, Huang J, Lu C, Li Q, Shen L, Chen X, Peng C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(46):e06139
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(46):e06139
KDM6B induces demethylation of H3K27me3 in MFN1 to modulate aberrant mitophagy in sepsis-induced acute lung injury.
Deng H, Zhu S, Song X, Guo Y, Ding X
Scientific reports 2025 Dec 8;15(1):43339
Scientific reports 2025 Dec 8;15(1):43339
Cyclin B2 facilitates glycolysis and tumor progression in pancreatic ductal adenocarcinoma by promoting histone lactylation.
Ma B, Li X, Ma Z, Yin Z, Gao L, Wang Y, Shi J, Liu X, Chen H
BMC cancer 2025 Dec 7;26(1):63
BMC cancer 2025 Dec 7;26(1):63
OPRK1 drives SLC9A3R1 progression to neuroendocrine prostate cancer.
Liang L, Shen Z, Zhang Y, Cheng Y, Yao B, Feng N, Zhao R
Cell death & disease 2025 Dec 7;17(1):68
Cell death & disease 2025 Dec 7;17(1):68
Genetic depletion or pharmacological degradation of EZH2 attenuates renal fibrosis via suppressing Notch signaling.
Yu C, Yao L, Du X, Yu J, Wang Y, Hou X, Shen F, Liu N, Zhuang S
Clinical epigenetics 2025 Dec 6;18(1):12
Clinical epigenetics 2025 Dec 6;18(1):12
Lactylation-driven KRT19 promotes non-small cell lung cancer progression by suppressing cellular senescence.
Zhang C, Du Y, Ji Y, Ye X, Lian J, Zhou H, Gao Z, Xu H, Tang Y, Fan Y, Zheng L
Journal of experimental & clinical cancer research : CR 2025 Dec 4;45(1):13
Journal of experimental & clinical cancer research : CR 2025 Dec 4;45(1):13
SARS-CoV-2 nsp14 induces the m(7)G methylation and the sequestration of host RNAs in stress granules.
Li X, Huang W, Zhang S, Wang W, Lin J, Wang Z, Zeng Q, Zhang F, Cao M, Chen Y, Peng Z, Sun Q, Liang Z, Zhuang J, Yang H, Hou P, Zhao B, Chen Y, Cao L, Yang Z, Guo D, Pan JA, Peng X
Communications biology 2025 Dec 30;9(1):182
Communications biology 2025 Dec 30;9(1):182
SREBP1-mediated lipogenesis promotes dedifferentiation and senescence of vascular smooth muscle cells through epigenetic remodeling.
Li B, Zhou K, Yin A, Liu Y, Wang X, Cui Y, Liu F, Liu Q, Zheng H, Mu Z, Chen K, Wu Y, Chang Y, Bao J
Nature communications 2025 Dec 26;17(1):835
Nature communications 2025 Dec 26;17(1):835
SIRT7 Promotes Hepatitis B Virus Transcription via the Upregulation of DDB1 Expression and Facilitation of DDB1 Recruitment to Covalently Closed Circular DNA.
Cao F, Zhao Y, Zhong S, Chen L, Wang XY, Zheng A, Zuo J, Wu M, Cheng Q, Tang KF
Frontiers in bioscience (Landmark edition) 2025 Dec 25;30(12):46445
Frontiers in bioscience (Landmark edition) 2025 Dec 25;30(12):46445
IGF2BP3-STAT3-METTL3 axis promotes malignant progression in hepatocellular carcinoma (HCC).
Xu Y, Cao Y, Yang J, Yu X, Yang L, Xie Y, Zhao J, Zhang Y
Human genomics 2025 Dec 25;20(1):21
Human genomics 2025 Dec 25;20(1):21
DNA repair pathway-related proteins are involved in the circularization step of microDNA eccDNA(fib-L).
Tong X, Qiu Q, Hu X, Liu Z, Yin M, Li L, Lei C, Feng Y, Zhu M, Gong C
Communications biology 2025 Dec 19;9(1):111
Communications biology 2025 Dec 19;9(1):111
CCL8 suppresses ovarian cancer progression via M1 macrophage polarization and NF-κB-mediated apoptosis.
Fang J, Zhao X, Wang J, Yang Y, Xiao Y
Scientific reports 2025 Dec 17;16(1):2960
Scientific reports 2025 Dec 17;16(1):2960
Nucleosome assembly protein-like 1 degradation-dependent novel cardioprotection mechanism of Wnt2 against ischemia‒reperfusion injury.
Wang Y, Chen L, Lin J, Liu X, Jin K, Huang C, Wang H, Jia J, Wu J, Ding Z, Gao P, Ge J, Gong H, Zou Y
Signal transduction and targeted therapy 2025 Dec 16;10(1):403
Signal transduction and targeted therapy 2025 Dec 16;10(1):403
Conformational Dynamics of PKM2 Regulate Hypoxia-Induced Pathological Retinal Angiogenesis.
Zhu P, Chang H, Yang Q, Chen W, Chang Q
Investigative ophthalmology & visual science 2025 Dec 1;66(15):23
Investigative ophthalmology & visual science 2025 Dec 1;66(15):23
Cuspidatyl Ferulate, a Novel Phenolic Acid from Hyssopus cuspidatus Borris, Protects Hepatocytes Against Oxidative Damage via Keap1 Interaction.
Liu X, Zhang Z, Gao D, Yang X, Liu L, Wang G, Song Z, Fang W, Wang S
Antioxidants (Basel, Switzerland) 2025 Dec 1;14(12)
Antioxidants (Basel, Switzerland) 2025 Dec 1;14(12)
Integrated stress response activation induced by usnic acid alleviates BCL-2 inhibitor ABT-199 resistance in acute myeloid leukemia.
Wu D, Li M, Hong Y, Jin L, Liu Q, Sun C, Li L, Han X, Deng S, Feng Y, Shen Y, Kai G
Journal of advanced research 2025 Aug;74:621-635
Journal of advanced research 2025 Aug;74:621-635
tsRNA-08614 inhibits glycolysis and histone lactylation by ALDH1A3 to confer oxaliplatin sensitivity in colorectal cancer.
Chen Z, Zhang Y, Yan F, Zhao G, Wang Y
Translational oncology 2025 Aug;58:102427
Translational oncology 2025 Aug;58:102427
The lncRNA ST18-AS1 suppresses pancreatic cancer progression by enhancing ST18 mRNA stability through anchoring FUS in the cytoplasm.
Cheng L, Yu H, Qin Y, Wang R, Su T, Lyu G, Huang Z, Li H, Jin Y, Li Y, Wang G
Oncogene 2025 Aug;44(32):2850-2863
Oncogene 2025 Aug;44(32):2850-2863
SETD5 facilitates stemness and represses ferroptosis via m6A-mediating PKM2 stabilization in non-small cell lung cancer.
Liu X, Cui Y, Gong J, Yu X, Cui Y, Xuan Y
Oncogene 2025 Aug;44(29):2474-2489
Oncogene 2025 Aug;44(29):2474-2489
The transcription factor Y-box binding protein 3 contributes to mechanical allodynia and anxiety-like behavior in trigeminal neuralgia by transcriptionally triggering period circadian regulator 1 in primary sensory neurons.
Liu D, Wang W, Li H, Khan S, Wang Q, Xia C, Nasir A, Wang Z, Bai Q
International journal of biological macromolecules 2025 Aug;320(Pt 4):146097
International journal of biological macromolecules 2025 Aug;320(Pt 4):146097
MAP3K15 facilitates multiple viral genes expression in crustaceans via Dorsal-CC-CL-STAT axis besides the JNK/P38 pathway.
Ran XQ, Liu CC, Xu XM, Wu XM, Kang CJ
PLoS pathogens 2025 Aug;21(8):e1013349
PLoS pathogens 2025 Aug;21(8):e1013349
Mitochondrial Protease AFG3L2 Inhibits Ferroptosis of Intestinal Epithelial Cells through PPARA/GPX4 Signaling Pathway to Improve Experimental Enteritis.
Chen W, Xu Z, Jiang J, Feng W, Li B
The American journal of pathology 2025 Aug;195(8):1443-1456
The American journal of pathology 2025 Aug;195(8):1443-1456
USP5-Rich Apoptotic Extracellular Vesicles Regulate Nucleus Pulposus Cells Apoptosis and DNA Damage Repair by Preventing E2F1 Proteasomal Degradation.
Shi P, Gao H, Cheng Z, Wu W, Zhang A, Chen X, Wu W, Zhang Y
Journal of extracellular vesicles 2025 Aug;14(8):e70148
Journal of extracellular vesicles 2025 Aug;14(8):e70148
Pretreatment with dimethyl fumarate prevents chronic pain and its comorbidities via Nrf2 pathway in a rat model of neuropathic pain.
Le ACT, Fiuza-Fernandes J, Silva JM, Sampaio MT, Texeira-Castro A, Duarte-Silva S, Leite-Almeida H
Brain, behavior, and immunity 2025 Aug;128:725-736
Brain, behavior, and immunity 2025 Aug;128:725-736
Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8-AS1/GPX4 Axis in Intrahepatic Cholangiocarcinoma.
Chen ZW, Shan JJ, Chen M, Wu Z, Zhao YM, Zhu HX, Jin X, Wang YX, Wu YB, Xiang Z, Ding ZW, Lin ZH, Wang LR, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(30):e01042
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(30):e01042
ACSS2-Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7.
Yuan M, Chen S, Lin Z, Yu R, Chao K, Ye S, Li Q, Ke H, Zhang C, Huang J, Liang G, Hu T, Gao X, Lan P, Wu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(30):e00461
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(30):e00461
SETD2 drives METTL14-mediated m(6)A to suppress Piezo1 Attenuation and activate TGM2 to promote pulmonary hypertension.
Zhao SS, Yuan C, Liu JL, Wu QC, Zhou XL
Cellular and molecular life sciences : CMLS 2025 Aug 8;82(1):302
Cellular and molecular life sciences : CMLS 2025 Aug 8;82(1):302
Integrative Proteomics and Histone PTMomics Study on Anti-TNBC Effect of JIB-04.
Tao S, Guo J, Zhang J, Zhang M, Wang Z, Zhang J, Li M, Liu B, Yuan J, Tan M, Zhao W
Journal of the American Society for Mass Spectrometry 2025 Aug 6;36(8):1609-1620
Journal of the American Society for Mass Spectrometry 2025 Aug 6;36(8):1609-1620
Arachidonic acid triggers spermidine synthase secretion from primary tumor to induce skeletal muscle weakness upon irradiation.
Zhang X, Nie Z, Wang S, Ma Y, Han D, Hu T, Liu L, Men L, Zhang T, Wu X, Li X, Hu S, Yuan M, Liu L, Wang C, Xu P, Xiang L, Liu J, Zhang Y, Zhu D, Lei H, Zhang L, Li X, Zhao Y, Yan W
Cell metabolism 2025 Aug 5;37(8):1766-1782.e12
Cell metabolism 2025 Aug 5;37(8):1766-1782.e12
SERBP1-PCIF1 complex-controlled m6Am modification in glutamatergic neurons of the primary somatosensory cortex is required for neuropathic pain in mice.
Huang Y, Ma G, Xie S, Wei R, Liu Y, Zeng Y, Zhao Y, Wang Q, Yang L, Huang H, Hao L, Zhao X, Wang H, Shen W, Wong SSC, Cao JL, Tao YX, Pan ZQ
Nature communications 2025 Aug 5;16(1):7225
Nature communications 2025 Aug 5;16(1):7225
Histone H3K27 acetylation mediated by KAT8 maintains antiviral trained immunity in shrimp induced by inactivated white spot syndrome virus.
Lv LX, Zhang P, Ma Y, Sun Y, Wang H, Zhao XF, Wang JX
Communications biology 2025 Aug 30;8(1):1314
Communications biology 2025 Aug 30;8(1):1314
Xiaoyaosan alleviates chronic psychological stress-induced TH17/Treg imbalance via modulation of the FKBP5/NF-κB axis.
Zhang Y, Luo XR, Zhou YH, Xue QY, Wu SY, Xu JY, Li GH, Liu BP, Zhang MJ, Tong GD, Ao HQ, Liao MM
Journal of ethnopharmacology 2025 Aug 29;352:120184
Journal of ethnopharmacology 2025 Aug 29;352:120184
Insect dome receptor directly recognizes viral envelopes to activate JAK/STAT signaling and induce conserved antiviral viperin expression.
Chen S, Tang Y, Zhang C, Li Y, Jia D, Wei T
Cell reports 2025 Aug 26;44(8):116155
Cell reports 2025 Aug 26;44(8):116155
Extrachromosomal DNA biogenesis is dependent on DNA looping and religation by YY1-Lig3-PARylation complex.
Qin LN, Wu T, Zhen XT, Zhao YL, Zhou JS, Cheng SB, Wang KW, Qiao S, Huang DZ, Zhang H, Sun T
Molecular cell 2025 Aug 21;85(16):3090-3107.e11
Molecular cell 2025 Aug 21;85(16):3090-3107.e11
A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma.
Li J, Ma C, Cao P, Guo W, Wang P, Yang Y, Ding B, Yin F, Li Z, Wang Y, Li S, Huang C, Wang X, Zhou T, Chang A, Zhao L, Gao S, Zhao T, Wang H, Yu J, Xu J, Feng Y, Hao J
Cell reports. Medicine 2025 Aug 19;6(8):102292
Cell reports. Medicine 2025 Aug 19;6(8):102292
LENG8 mediates RNA nuclear retention and degradation in eukaryotes.
Tian L, Liu L, Yoon Y, Soles LV, Valdez M, Jeong J, Yu C, Huang L, Shi Y
bioRxiv : the preprint server for biology 2025 Aug 16;
bioRxiv : the preprint server for biology 2025 Aug 16;
MRO/HNRNPU/CCL5 feedback loop amplifies M2 macrophage and breast cancer cell crosstalk to drive progression.
Zeng Z, Bao X, Lei S, Tang W, Tai H, Wang L, Li D, Liu S, Chen T
Journal of translational medicine 2025 Aug 15;23(1):920
Journal of translational medicine 2025 Aug 15;23(1):920
MSC-derived exosomes alleviate oxidative stress-induced lysosomal membrane permeabilization damage in degenerated nucleus pulposus cells via promoting m6A demethylation of Nrf2.
Gao X, Jia S, Gao L, Chen S, Zhang Y, Liang X, Zhang L, Zhang B, Meng C
Free radical biology & medicine 2025 Aug 1;235:213-230
Free radical biology & medicine 2025 Aug 1;235:213-230
CIP2A promotes bronchiolitis obliterans by activating the NF‑κB pathway.
Zhou X, Zhao X, Li Y, Zhang B
Molecular medicine reports 2025 Apr;31(4)
Molecular medicine reports 2025 Apr;31(4)
Hydrogen sulfide sustains mitochondria functions via targeting mitochondria fission regulator 1 like protein to restore human cytotrophoblast invasion and migration.
Feng H, Tian C, Jiang W, Sun Z, Li Y, Han B, Chen L, Wang D, Xiang H, Zhu J, Song W, Li J, Cai Y, Wang S, Li Y
International journal of biological macromolecules 2025 Apr;299:140240
International journal of biological macromolecules 2025 Apr;299:140240
TGR5 attenuates DOCA-salt hypertension through regulating histone H3K4 methylation of ENaC in the kidney.
Xu L, Wu X, Long L, Li S, Huang M, Li M, Feng P, Levi M, Chen W, Wang L, Li C, Wang W
Metabolism: clinical and experimental 2025 Apr;165:156133
Metabolism: clinical and experimental 2025 Apr;165:156133
SAE1 promotes tumor cell malignancy via SUMOylation and liquid-liquid phase separation facilitated nuclear export of p27.
Wang L, Min J, Qian J, Huang X, Yu X, Cao Y, Sun S, Ke M, Lv X, Su W, Guo M, Li N, Qi S, Huang H, Gu C, Yang Y
Acta pharmaceutica Sinica. B 2025 Apr;15(4):1991-2007
Acta pharmaceutica Sinica. B 2025 Apr;15(4):1991-2007
GRK2 activates TRAF2-NF-κB signalling to promote hyperproliferation of fibroblast-like synoviocytes in rheumatoid arthritis.
Han C, Jiang L, Wang W, Zuo S, Gu J, Chen L, Chen Z, Kuai J, Yang X, Xu L, Ma Y, Wei W
Acta pharmaceutica Sinica. B 2025 Apr;15(4):1956-1973
Acta pharmaceutica Sinica. B 2025 Apr;15(4):1956-1973
Lipid Droplets Metabolism Mediated by ANXA7-PPARγ Signaling Axis Regulates Spinal Cord Injury Repair in Mice.
Chen L, Liu H, Jiang L, Wang Z, Chang Y, Li N, Feng S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2417326
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2417326
Positive Feedback Regulation between KLF5 and XPO1 Promotes Cell Cycle Progression of Basal like Breast Cancer.
Tang Y, Liu R, Zhu J, He Q, Pan C, Zhou Z, Sun J, Li F, Zhang L, Shi Y, Yao J, Jiang D, Chen C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2412096
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2412096
CK2B Induces CD8(+) T-Cell Exhaustion through HDAC8-Mediated Epigenetic Reprogramming to Limit the Efficacy of Anti-PD-1 Therapy in Non-Small-Cell Lung Cancer.
Liu S, Ma S, Liu G, Hou L, Guan Y, Liu L, Meng Y, Yu W, Liu T, Zhou L, Yuan Z, Pang S, Zhang S, Li J, Ren X, Sun Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2411053
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2411053
The highly expressed GOLPH3 in colorectal cancer cells activates smoothened to drive glycolysis and promote cancer cell growth and radiotherapy resistance.
Zhu K, Fan J, Cai H, Zhou C, Gong Z, Li Z, Yu J
Journal of gastrointestinal oncology 2025 Apr 30;16(2):415-434
Journal of gastrointestinal oncology 2025 Apr 30;16(2):415-434
Oxidized low-density lipoprotein induced ferroptosis in nucleus pulposus cell contributes to intervertebral disc degeneration via LOX-1/NF-κB/NOX signal.
Liu Z, Li X, Pan J, Qi D, Wang D, Huang Y, Wu D, Li L
International immunopharmacology 2025 Apr 24;153:114455
International immunopharmacology 2025 Apr 24;153:114455
Neutrophil extracellular traps induced by neoadjuvant chemotherapy of breast cancer promotes vascular endothelial damage.
Kong L, Hu S, Zhao Y, Huang Y, Xiang X, Yu Y, Mao X, Xie K, Zhu X, Xu P
Breast cancer research : BCR 2025 Apr 23;27(1):61
Breast cancer research : BCR 2025 Apr 23;27(1):61
Nicotinamide mononucleotide promotes female germline stem cell proliferation by activating the H4K16ac-Hmgb1-Fyn-PLD signaling pathway through epigenetic remodeling.
Zhou H, Liu Y, Tian GG, Wu J
Cell & bioscience 2025 Apr 17;15(1):48
Cell & bioscience 2025 Apr 17;15(1):48
The dual HDAC/PI3K inhibitor CUDC-907 inhibits the growth and proliferation of MYC-driven Group 3 medulloblastoma.
Gou P, Fang C, Xu M, Zhang D, Wu X, Zhang L, Li X, Li M, Gan L, Luo J, Cui H, Liang P
Cell death discovery 2025 Apr 14;11(1):172
Cell death discovery 2025 Apr 14;11(1):172
Epigenetic modulation of RIPK3 by transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis.
Vecchio A, Colasuonno F, Occhigrossi L, Pitolli C, Bellanca V, Ciccarone F, D'Eletto M, Di Sano F, Pagliarini V, Sette C, Piacentini M, Rossin F
Cellular and molecular life sciences : CMLS 2025 Apr 10;82(1):154
Cellular and molecular life sciences : CMLS 2025 Apr 10;82(1):154
miR-32-5p suppresses the progression of hepatocellular carcinoma by regulating the GSK3β/NF-κB signaling.
Wang G, Yang Q, Han Y, Zhang Y, Pan W, Ma Z, Tian H, Qu X
Acta biochimica et biophysica Sinica 2025 Apr 1;57(7):1125-1138
Acta biochimica et biophysica Sinica 2025 Apr 1;57(7):1125-1138
AP001885.4 promotes the proliferation of esophageal squamous cell carcinoma cells by histone lactylation- and NF-κB (p65)-dependent transcription activation and METTL3-mediated mRNA stability of c-myc.
Fu C, Jiang W, Wang C, Song SJ, Tao H, Zhang XG, Li WT, Jin X, Yu BB, Hao JJ, Sun WJ, Bai J, Shi ZZ
Animal cells and systems 2024;28(1):536-550
Animal cells and systems 2024;28(1):536-550
Catalpol alleviates amyloid- generation and neuronal oxidative stress injury via activating the Keap1-Nrf2/ARE signaling pathway in the immortalized lymphocytes from patients with late-onset Alzheimer's disease and SKNMC cells co-culture model.
Xiang C, Lu Y, Hao R, Wei Y, Hu Y, Yu G
Iranian journal of basic medical sciences 2024;27(12):1547-1557
Iranian journal of basic medical sciences 2024;27(12):1547-1557
Dietary Fiber-Derived Microbial Butyrate Suppresses ILC2-Dependent Airway Inflammation in COPD.
Jiang M, Wang J, Li Z, Xu D, Jing J, Li F, Ding J, Li Q
Mediators of inflammation 2024;2024:6263447
Mediators of inflammation 2024;2024:6263447
The m6A modification-mediated positive feedback between glycolytic lncRNA SLC2A1-DT and c-Myc promotes tumorigenesis of hepatocellular carcinoma.
Zeng Z, Wang J, Xu F, Hu P, Hu Y, Zhuo W, Chen D, Han S, Wang F, Zhao Y, Huang Y, Zhao G
International journal of biological sciences 2024;20(5):1744-1762
International journal of biological sciences 2024;20(5):1744-1762
KMT2D mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-induced regulatory T cell trafficking via FBXW7-NOTCH-MYC/TGF-β1 axis.
Liu QX, Zhu Y, Yi HM, Shen YG, Wang L, Cheng S, Xu PP, Xu HM, Zhou LT, Huang YH, Huang CX, Fu D, Ji MM, Wang CF, Zhao WL
International journal of biological sciences 2024;20(10):3972-3985
International journal of biological sciences 2024;20(10):3972-3985
RASSF4 Attenuates Metabolic Dysfunction-Associated Steatotic Liver Disease Progression via Hippo Signaling and Suppresses Hepatocarcinogenesis.
Xu C, Fang T, Qu J, Miao Y, Tian L, Zhang M, Zhuang H, Sun B, Chen L
Cellular and molecular gastroenterology and hepatology 2024;18(2):101348
Cellular and molecular gastroenterology and hepatology 2024;18(2):101348
MicroRNA-204-5p Ameliorates Renal Injury via Regulating Keap1/Nrf2 Pathway in Diabetic Kidney Disease.
Dong J, Liu M, Bian Y, Zhang W, Yuan C, Wang D, Zhou Z, Li Y, Shi Y
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:75-92
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:75-92
Puerarin ameliorates non-alcoholic fatty liver disease by inhibiting lipid metabolism through FMO5.
Li Z, Cao W, Zhang Y, Lai S, Ye Y, Bao J, Fu A
Frontiers in pharmacology 2024;15:1423634
Frontiers in pharmacology 2024;15:1423634
Staphylococcus aureus wraps around Candida albicans and synergistically escapes from Neutrophil extracellular traps.
Jing Q, Liu R, Jiang Q, Liu Y, He J, Zhou X, Yu OY, Chu CH, Cheng L, Ren B, Li M
Frontiers in immunology 2024;15:1422440
Frontiers in immunology 2024;15:1422440
Placental mesenchymal stem cells suppress inflammation and promote M2-like macrophage polarization through the IL-10/STAT3/NLRP3 axis in acute lung injury.
Nie Z, Fan Q, Jiang W, Wei S, Luo R, Hu H, Liu G, Lei Y, Xie S
Frontiers in immunology 2024;15:1422355
Frontiers in immunology 2024;15:1422355
Extracellular putrescine can augment the epithelial-mesenchymal transition of gastric cancer cells by promoting MAL2 expression by elevating H3K27ac in its promoter region.
Bi C, Li C, Xing L, Lu Z, Liu H, Hu T, Wang B, Liu C
American journal of cancer research 2024;14(6):2805-2822
American journal of cancer research 2024;14(6):2805-2822
Methyl-CpG-binding 2 K271 lactylation-mediated M2 macrophage polarization inhibits atherosclerosis.
Chen L, Zhang M, Yang X, Wang Y, Huang T, Li X, Ban Y, Li Q, Yang Q, Zhang Y, Zheng Y, Wang D, Wang X, Shi X, Zhang M, Sun Y, Wu J
Theranostics 2024;14(11):4256-4277
Theranostics 2024;14(11):4256-4277
Full-length GSDME mediates pyroptosis independent from cleavage.
Zhou B, Jiang ZH, Dai MR, Ai YL, Xiao L, Zhong CQ, Wu LZ, Chen QT, Chen HZ, Wu Q
Nature cell biology 2024 Sep;26(9):1545-1557
Nature cell biology 2024 Sep;26(9):1545-1557
Moxibustion ameliorates ovarian function in premature ovarian insufficiency rats by activating cAMP/PKA/CREB to promote steroidogenesis in ovarian granulosa cells.
Zhao R, Ran L, Yao H, He Y, Lu X, Zhu W, Zhang Y, Zhang T, Shi S, Luo Z, Zhang C
The Journal of steroid biochemistry and molecular biology 2024 Sep;242:106547
The Journal of steroid biochemistry and molecular biology 2024 Sep;242:106547
Puerarin suppresses macrophage M1 polarization to alleviate renal inflammatory injury through antagonizing TLR4/MyD88-mediated NF-κB p65 and JNK/FoxO1 activation.
Hu Z, Chen D, Yan P, Zheng F, Zhu H, Yuan Z, Yang X, Zuo Y, Chen C, Lu H, Wu L, Lyu J, Bai Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155813
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155813
NSD2-mediated H3K36me2 exacerbates osteoporosis via activation of hoxa2 in bone marrow mesenchymal stem cells.
He G, Ke Y, Yuan J, Zhang B, Dai L, Liu J, Zhang X
Cellular signalling 2024 Sep;121:111294
Cellular signalling 2024 Sep;121:111294
Uremic Toxin Receptor AhR Facilitates Renal Senescence and Fibrosis via Suppressing Mitochondrial Biogenesis.
Xie H, Yang N, Lu L, Sun X, Li J, Wang X, Guo H, Zhou L, Liu J, Wu H, Yu C, Zhang W, Lu L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(33):e2402066
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(33):e2402066
Design, Synthesis, and Biological Evaluation of HDAC Inhibitors Containing Natural Product-Inspired N-Linked 2-Acetylpyrrole Cap.
Zhang H, Shen Q, Hu Z, Wu PQ, Chen Y, Zhao JX, Yue JM
Molecules (Basel, Switzerland) 2024 Sep 30;29(19)
Molecules (Basel, Switzerland) 2024 Sep 30;29(19)
Indoxyl sulfate induces retinal microvascular injury via COX-2/PGE(2) activation in diabetic retinopathy.
Zhou L, Sun H, Chen G, Li C, Liu D, Wang X, Meng T, Jiang Z, Yang S, Yang MM
Journal of translational medicine 2024 Sep 27;22(1):870
Journal of translational medicine 2024 Sep 27;22(1):870
Qin-Yu-Qing-Chang decoction reshapes colonic metabolism by activating PPAR-γ signaling to inhibit facultative anaerobes against DSS-induced colitis.
Xu F, Hu J, Li Y, Cheng C, Au R, Tong Y, Wu Y, Cui Y, Fang Y, Chen H, Zhu L, Shen H
Chinese medicine 2024 Sep 26;19(1):130
Chinese medicine 2024 Sep 26;19(1):130
Transient splicing inhibition causes persistent DNA damage and chemotherapy vulnerability in triple-negative breast cancer.
Caggiano C, Petrera V, Ferri M, Pieraccioli M, Cesari E, Di Leone A, Sanchez MA, Fabi A, Masetti R, Naro C, Sette C
Cell reports 2024 Sep 24;43(9):114751
Cell reports 2024 Sep 24;43(9):114751
PICKLE-mediated nucleosome condensing drives H3K27me3 spreading for the inheritance of Polycomb memory during differentiation.
Liang Z, Zhu T, Yu Y, Wu C, Huang Y, Hao Y, Song X, Fu W, Yuan L, Cui Y, Huang S, Li C
Molecular cell 2024 Sep 19;84(18):3438-3454.e8
Molecular cell 2024 Sep 19;84(18):3438-3454.e8
Forkhead box protein FOXK1 disrupts the circadian rhythm to promote breast tumorigenesis in response to insulin resistance.
Zhang Z, Zhao M, Wang Q, Wang X, Wang Y, Ge Y, Wu Z, Wang W, Shan L
Cancer letters 2024 Sep 1;599:217147
Cancer letters 2024 Sep 1;599:217147
Exogenous thyroxine increases cardiac GLUT4 translocation in insulin resistant OLETF rats.
Mendez DA, Soñanez-Organis JG, Yang X, Vazquez-Anaya G, Nishiyama A, Ortiz RM
Molecular and cellular endocrinology 2024 Sep 1;590:112254
Molecular and cellular endocrinology 2024 Sep 1;590:112254
Loss of Malignancy of Super-Methotrexate-resistant Osteosarcoma Cells Is Associated With an Increase of Methylated Histone Marks H3K9me3 and H3K27me3.
Aoki Y, Kubota Y, Masaki N, Obara K, Tome Y, Bouvet M, Nishida K, Hoffman RM
Anticancer research 2024 Oct;44(10):4213-4218
Anticancer research 2024 Oct;44(10):4213-4218
ATR/Chk1 interacting lncRNA modulates DNA damage response to induce breast cancer chemoresistance.
Luo R, Wu J, Chen X, Liu Y, Liu D, Song E, Luo ML
Cell insight 2024 Oct;3(5):100183
Cell insight 2024 Oct;3(5):100183
UBE2S facilitates glioblastoma progression through activation of the NF-κB pathway via attenuating K11-linked ubiquitination of AKIP1.
Han Z, Xu L, Wang A, Wang B, Liu Q, Liu H, Liu Q, Gang Z, Yu S, Mu L, Weng C, Lin Z, Hu L
International journal of biological macromolecules 2024 Oct;278(Pt 1):134426
International journal of biological macromolecules 2024 Oct;278(Pt 1):134426
Corilagin alleviates ferroptosis in diabetic retinopathy by activating the Nrf2 signaling pathway.
Shi W, Dong Y, Liu S, Li F, Zhu C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117409
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117409
S100A2 activation promotes interstitial fibrosis in kidneys by FoxO1-mediated epithelial-mesenchymal transition.
Yang X, Zheng F, Yan P, Liu X, Chen X, Du X, Zhang Y, Wang P, Chen C, Lu H, Bai Y
Cell biology and toxicology 2024 Oct 9;40(1):86
Cell biology and toxicology 2024 Oct 9;40(1):86
Characterizations of Protein Arginine Deiminase 1 as a Substrate of NTMT1: Implications of Nα-Methylation in Protein Stability and Interaction.
Meng Y, Li Z, He M, Zhang Q, Deng Y, Wang Y, Huang R
Journal of proteome research 2024 Oct 4;23(10):4589-4600
Journal of proteome research 2024 Oct 4;23(10):4589-4600
Protective effect of 8-Gingerol, a potent constituent of ginger, on acute lung injury following hemorrhagic shock in rats.
Lian P, Huan Z, Wang Y, Yao H, Han S, Ge X
Experimental animals 2024 Oct 23;73(4):446-457
Experimental animals 2024 Oct 23;73(4):446-457
Cecal necroptosis triggers lethal cardiac dysfunction in TNF-induced severe SIRS.
Wu J, Ai T, He P, Shi Q, Li Y, Zhang Z, Chen M, Huang Z, Wu S, Chen W, Han J
Cell reports 2024 Oct 22;43(10):114778
Cell reports 2024 Oct 22;43(10):114778
Reduced expression of NUPR1 alleviates epilepsy progression via attenuating ER stress.
Cui Y, Yang G, Li H, Sun J, Liu X, Xia X
Biochemical and biophysical research communications 2024 Oct 20;730:150365
Biochemical and biophysical research communications 2024 Oct 20;730:150365
KLF4 regulates trophoblast function and associates with unexplained recurrent spontaneous abortion.
Tan Y, Wang J, Liu C, Wu S, Zhou M, Zhang Y, Yin T, Yang J
Journal of translational medicine 2024 Oct 10;22(1):922
Journal of translational medicine 2024 Oct 10;22(1):922
Acetate utilization promotes hormone therapy resistance in prostate cancer through neuroendocrine differentiation.
Gao D, Shen Y, Xu L, Sun Y, Hu H, Xu B, Wang Z, Xu H
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Nov;77:101158
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Nov;77:101158
Geniposidic Acid Attenuates Chronic Tubulointerstitial Nephropathy Through Regulation of the NF-ƙB/Nrf2 Pathway Via Aryl Hydrocarbon Receptor Signaling.
Wang YN, Li XJ, Wang WF, Zou L, Miao H, Zhao YY
Phytotherapy research : PTR 2024 Nov;38(11):5441-5457
Phytotherapy research : PTR 2024 Nov;38(11):5441-5457
The PRMT6/STAT1/ACSL1 axis promotes ferroptosis in diabetic nephropathy.
Hong J, Li X, Hao Y, Xu H, Yu L, Meng Z, Zhang J, Zhu M
Cell death and differentiation 2024 Nov;31(11):1561-1575
Cell death and differentiation 2024 Nov;31(11):1561-1575
The highly conserved region within exonuclease III-like in PML-I regulates the cytoplasmic localization of PML-NBs.
Liang X, Chen J, Yan P, Chen Z, Gao C, Bai R, Tang J
The Journal of biological chemistry 2024 Nov;300(11):107872
The Journal of biological chemistry 2024 Nov;300(11):107872
Sirt6 Mono-ADP-Ribosylates YY1 to Promote Dystrophin Expression for Neuromuscular Transmission.
Zhang W, Bai L, Xu W, Liu J, Chen Y, Lin W, Lu H, Wang B, Luo B, Peng G, Zhang K, Shen C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(44):e2406390
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(44):e2406390
Lung-Targeted Lipid Nanoparticle-Delivered siUSP33 Attenuates SARS-CoV-2 Replication and Virulence by Promoting Envelope Degradation.
Zhou Y, Liao Y, Fan L, Wei X, Huang Q, Yang C, Feng W, Wu Y, Gao X, Shen X, Zhou J, Xia Z, Zhang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(42):e2406211
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(42):e2406211
Unveiling Smyd-2's Role in Cytoplasmic Nrf-2 Sequestration and Ferroptosis Induction in Hippocampal Neurons After Cerebral Ischemia/Reperfusion.
Liu D, Zhu Y
Cells 2024 Nov 28;13(23)
Cells 2024 Nov 28;13(23)
Mitochondrial miRNAs and fibromyalgia: new biomarker candidates.
Rasulova K, Dilek B, Kavak DE, Pehlivan M, Kizildag S
Molecular biology reports 2024 Nov 26;52(1):16
Molecular biology reports 2024 Nov 26;52(1):16
Biliverdin improved angiogenesis and suppressed apoptosis via PI3K/Akt-mediated Nrf2 antioxidant system to promote ischemic flap survival.
Yao Z, Xue K, Chen J, Zhang Y, Zhang G, Zheng Z, Li Z, Li Z, Wang F, Sun X, Shen L, Mao C, Lin C
Free radical biology & medicine 2024 Nov 20;225:35-52
Free radical biology & medicine 2024 Nov 20;225:35-52
Impaired mitochondrial oxidative phosphorylation induces CD8(+) T cell exhaustion.
Liu M, Fu X, Yi Q, Xu E, Dong L
Biochemical and biophysical research communications 2024 Nov 19;734:150738
Biochemical and biophysical research communications 2024 Nov 19;734:150738
Effects on Synaptic Plasticity Markers in Fetal Mice and HT22 Neurons upon F-53B Exposure: The Role of PKA Cytoplasmic Retention.
Li SP, Zeng HX, Qin SJ, Li QQ, Wu LY, Wu QZ, Lin LZ, Dong GH, Zeng XW
Environment & health (Washington, D.C.) 2024 Nov 15;2(11):776-785
Environment & health (Washington, D.C.) 2024 Nov 15;2(11):776-785
Alarmin-loaded extracellular lipid droplets induce airway neutrophil infiltration during type 2 inflammation.
Rao Z, Liu S, Li Z, Wang Q, Gao F, Peng H, Ren D, Zang Y, Li H, Li Y, Hu Q, He D, Xu H
Immunity 2024 Nov 12;57(11):2514-2529.e7
Immunity 2024 Nov 12;57(11):2514-2529.e7
TIRR regulates mRNA export and association with P-bodies in response to DNA damage.
Glossop MS, Chelysheva I, Ketley RF, Alagia A, Gullerova M
Nucleic acids research 2024 Nov 11;52(20):12633-12649
Nucleic acids research 2024 Nov 11;52(20):12633-12649
HACE1 exerts a neuroprotective role against oxidative stress in cerebral ischemia-reperfusion injury by activating the PI3K/AKT/Nrf2 pathway.
Zhang X, Wang X, Yin L, Wang D, Jiao H, Liu X, Zheng J
Neuroscience 2024 Nov 1;559:249-262
Neuroscience 2024 Nov 1;559:249-262
TIPE2 aggravates experimental colitis and disrupts intestinal epithelial barrier integrity by activating JAK2/STAT3/SOCS3 signal pathway.
Zeng L, Wang Y, Shen J, Wei X, Wu Y, Chi X, Zheng X, Yu X, Shi Y, Liu W
Experimental cell research 2024 Nov 1;443(1):114287
Experimental cell research 2024 Nov 1;443(1):114287
Syk-dependent homologous recombination activation promotes cancer resistance to DNA targeted therapy.
Zhou Q, Tu X, Hou X, Yu J, Zhao F, Huang J, Kloeber J, Olson A, Gao M, Luo K, Zhu S, Wu Z, Zhang Y, Sun C, Zeng X, Schoolmeester KJ, Weroha JS, Hu X, Jiang Y, Wang L, Mutter RW, Lou Z
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 May;74:101085
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 May;74:101085
Synaptic vesicle protein 2A mitigates parthanatos via apoptosis-inducing factor in a rat model of pharmacoresistant epilepsy.
Li C, Wang Z, Ren M, Ren S, Wu G, Wang L
CNS neuroscience & therapeutics 2024 May;30(5):e14778
CNS neuroscience & therapeutics 2024 May;30(5):e14778
m(6)A-induced TRIB3 regulates Hippo pathway through interacting with LATS1 to promote the progression of lung adenocarcinoma.
Wu J, Yi T, Zhuo C, Wang D, Zhang M, Hu R, Wu D, Hou G, Xing Y
Journal of cellular physiology 2024 May;239(5):e31220
Journal of cellular physiology 2024 May;239(5):e31220
Apoptosis-inducing factor 1 mediates Vibrio splendidus-induced coelomocyte apoptosis via importin β dependent nuclear translocation in Apostichopus japonicus.
Qian Z, Chen K, Yang L, Li C
Fish & shellfish immunology 2024 May;148:109491
Fish & shellfish immunology 2024 May;148:109491
Pirfenidone alleviates fibrosis by acting on tumour-stroma interplay in pancreatic cancer.
Lei Y, Xu J, Xiao M, Wu D, Xu H, Yang J, Mao X, Pan H, Yu X, Shi S
British journal of cancer 2024 May;130(9):1505-1516
British journal of cancer 2024 May;130(9):1505-1516
NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors.
Wang Y, Liu X, Zuo X, Wang C, Zhang Z, Zhang H, Zeng T, Chen S, Liu M, Chen H, Song Q, Li Q, Yang C, Le Y, Xing J, Zhang H, An J, Jia W, Kang L, Zhang H, Xie H, Ye J, Wu T, He F, Zhang X, Li Y, Zhou G
Cell genomics 2024 May 8;4(5):100550
Cell genomics 2024 May 8;4(5):100550
Cynarin alleviates acetaminophen-induced acute liver injury through the activation of Keap1/Nrf2-mediated lipid peroxidation defense via the AMPK/SIRT3 signaling pathway.
Zhao L, Zhang X, Chen Z, Lai Y, Xu J, Zhou R, Ma P, Cai W, Zeng Y, Wu X, Ying H, Yu F
Food & function 2024 May 7;15(9):4954-4969
Food & function 2024 May 7;15(9):4954-4969
D-mannose alleviates intervertebral disc degeneration through glutamine metabolism.
Dong ZL, Jiao X, Wang ZG, Yuan K, Yang YQ, Wang Y, Li YT, Wang TC, Kan TY, Wang J, Tao HR
Military Medical Research 2024 May 6;11(1):28
Military Medical Research 2024 May 6;11(1):28
Microglial Pdcd4 deficiency mitigates neuroinflammation-associated depression via facilitating Daxx mediated PPARγ/IL-10 signaling.
Li Y, Zhan B, Zhuang X, Zhao M, Chen X, Wang Q, Liu Q, Zhang L
Journal of neuroinflammation 2024 May 31;21(1):143
Journal of neuroinflammation 2024 May 31;21(1):143
Medical ozone alleviates acute lung injury by enhancing phagocytosis targeting NETs via AMPK/SR-A1 axis.
Yan C, Zhang Y, Jin L, Liu X, Zhu X, Li Q, Wang Y, Hu L, He X, Bao H, Zhu X, Wang Q, Liu WT
Journal of biomedical research 2024 May 29;38(6):569-584
Journal of biomedical research 2024 May 29;38(6):569-584
PRMT1 promotes epigenetic reprogramming associated with acquired chemoresistance in pancreatic cancer.
Nguyen CDK, Colón-Emeric BA, Murakami S, Shujath MNY, Yi C
Cell reports 2024 May 28;43(5):114176
Cell reports 2024 May 28;43(5):114176
Excessive proliferating cell nuclear antigen attenuates endometrial adhesive capacity and decidualization in patients with recurrent implantation failure.
Zhao H, Yu M, Li Q, Chen G, Liu X, Bao H
Human reproduction (Oxford, England) 2024 May 23;
Human reproduction (Oxford, England) 2024 May 23;
Mycobacterial CpsA activates type I IFN signaling in macrophages via cGAS-mediated pathway.
Ding Y, Tong J, Luo G, Sun R, Bei C, Feng Z, Meng L, Wang F, Zhou J, Chen Z, Li D, Fan Y, Song S, Wang D, Feng CG, Liu H, Chen Q, Yan B, Gao Q
iScience 2024 May 17;27(5):109807
iScience 2024 May 17;27(5):109807
Synergistic effect of mesenchymal stem cell-derived extracellular vesicle and miR-137 alleviates autism-like behaviors by modulating the NF-κB pathway.
Qin Q, Shan Z, Xing L, Jiang Y, Li M, Fan L, Zeng X, Ma X, Zheng D, Wang H, Wang H, Liu H, Liang S, Wu L, Liang S
Journal of translational medicine 2024 May 13;22(1):446
Journal of translational medicine 2024 May 13;22(1):446
Deubiquitinase USP4 suppresses antitumor immunity by inhibiting IRF3 activation and tumor cell-intrinsic interferon response in colorectal cancer.
Zhou Y, Li H, Zhang Y, Zhao E, Huang C, Pan X, Shu F, Liu Z, Tang N, Li F, Liao W
Cancer letters 2024 May 1;589:216836
Cancer letters 2024 May 1;589:216836
Single-cell transcriptome analysis reveals the association between histone lactylation and cisplatin resistance in bladder cancer.
Li F, Zhang H, Huang Y, Li D, Zheng Z, Xie K, Cao C, Wang Q, Zhao X, Huang Z, Chen S, Chen H, Fan Q, Deng F, Hou L, Deng X, Tan W
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Mar;73:101059
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Mar;73:101059
KAT8 is upregulated and recruited to the promoter of Atg8 by FOXO to induce H4 acetylation for autophagy under 20-hydroxyecdysone regulation.
Liu TW, Zhao YM, Jin KY, Wang JX, Zhao XF
The Journal of biological chemistry 2024 Mar;300(3):105704
The Journal of biological chemistry 2024 Mar;300(3):105704
Glucose-derived glutamate drives neuronal terminal differentiation in vitro.
D'Andrea L, Audano M, Pedretti S, Pelucchi S, Stringhi R, Imperato G, De Cesare G, Cambria C, Laporte MH, Zamboni N, Antonucci F, Di Luca M, Mitro N, Marcello E
EMBO reports 2024 Mar;25(3):991-1021
EMBO reports 2024 Mar;25(3):991-1021
Chemical Proteomics Reveals N(ε)-Fatty-Acylation of Septins by Rho Inactivation Domain (RID) of the Vibrio MARTX Toxin to Alter Septin Localization and Organization.
Xu Y, Ding K, Peng T
Molecular & cellular proteomics : MCP 2024 Mar;23(3):100730
Molecular & cellular proteomics : MCP 2024 Mar;23(3):100730
EHMT2 promotes tumorigenesis in GNAQ/11-mutant uveal melanoma via ARHGAP29-mediated RhoA pathway.
Li Y, Zhu T, Yang J, Zhang Q, Xu S, Ge S, Jia R, Zhang J, Fan X
Acta pharmaceutica Sinica. B 2024 Mar;14(3):1187-1203
Acta pharmaceutica Sinica. B 2024 Mar;14(3):1187-1203
Chicken speckle-type POZ protein (SPOP) negatively regulates MyD88/NF-κB signaling pathway mediated proinflammatory cytokine production to promote the replication of Newcastle disease virus.
Meng Z, Wang Y, Kong X, Cen M, Duan Z
Poultry science 2024 Mar;103(3):103461
Poultry science 2024 Mar;103(3):103461
Antagonizing roles of SHP1 in the pathogenesis of Helicobacter pylori infection.
Chen S, Zhao H, Tian Y, Wu Q, Zhang J, Liu S, Zhang Y, Wu Y, Li B, Chen S, Wang Z, Xiao R, Ji X
Helicobacter 2024 Mar-Apr;29(2):e13066
Helicobacter 2024 Mar-Apr;29(2):e13066
Histone lactylation promotes malignant progression by facilitating USP39 expression to target PI3K/AKT/HIF-1α signal pathway in endometrial carcinoma.
Wei S, Zhang J, Zhao R, Shi R, An L, Yu Z, Zhang Q, Zhang J, Yao Y, Li H, Wang H
Cell death discovery 2024 Mar 8;10(1):121
Cell death discovery 2024 Mar 8;10(1):121
Macrophage-derived exosomal HMGB3 regulates silica-induced pulmonary inflammation by promoting M1 macrophage polarization and recruitment.
Qin X, Niu Z, Chen H, Hu Y
Particle and fibre toxicology 2024 Mar 7;21(1):12
Particle and fibre toxicology 2024 Mar 7;21(1):12
CDKL1 potentiates the antitumor efficacy of radioimmunotherapy by binding to transcription factor YBX1 and blocking PD-L1 expression in lung cancer.
Li Z, Xue H, Li J, Zheng Z, Liu Z, Dong X, Wang H, Chen J, Xu S
Journal of experimental & clinical cancer research : CR 2024 Mar 22;43(1):89
Journal of experimental & clinical cancer research : CR 2024 Mar 22;43(1):89
Interaction between the SFTSV envelope glycoprotein Gn and STING inhibits the formation of the STING-TBK1 complex and suppresses the NF-κB signaling pathway.
Jia Y, Li F, Liu Z, Liu S, Huang M, Gao X, Su X, Wang Z, Wang T
Journal of virology 2024 Mar 19;98(3):e0181523
Journal of virology 2024 Mar 19;98(3):e0181523
L-Theanine alleviates heat stress through modulation of gut microbiota and immunity.
Liu S, Wang B, Lin L, Xu W, Gong ZH, Xiao WJ
Journal of the science of food and agriculture 2024 Mar 15;104(4):2059-2072
Journal of the science of food and agriculture 2024 Mar 15;104(4):2059-2072
MRE11A: a novel negative regulator of human DNA mismatch repair.
Du D, Yang Y, Zhang Y, Wang G, Chen L, Guan X, Rasmussen LJ, Liu D
Cellular & molecular biology letters 2024 Mar 14;29(1):37
Cellular & molecular biology letters 2024 Mar 14;29(1):37
Alistipes indistinctus-derived hippuric acid promotes intestinal urate excretion to alleviate hyperuricemia.
Xu YX, Liu LD, Zhu JY, Zhu SS, Ye BQ, Yang JL, Huang JY, Huang ZH, You Y, Li WK, He JL, Xia M, Liu Y
Cell host & microbe 2024 Mar 13;32(3):366-381.e9
Cell host & microbe 2024 Mar 13;32(3):366-381.e9
Ammonia stress-induced heat shock factor 1 enhances white spot syndrome virus infection by targeting the interferon-like system in shrimp.
Wang X-X, Zhang H, Gao J, Wang X-W
mBio 2024 Mar 13;15(3):e0313623
mBio 2024 Mar 13;15(3):e0313623
Echinacoside alleviates glucocorticoid induce osteonecrosis of femoral head in rats through PI3K/AKT/FOXO1 pathway.
Huang LK, Zeng XS, Jiang ZW, Peng H, Sun F
Chemico-biological interactions 2024 Mar 1;391:110893
Chemico-biological interactions 2024 Mar 1;391:110893
Ponicidin-induced conformational changes of HSP90 regulates the MAPK pathway to relieve ulcerative colitis.
Zhang X, Xu Y, Fan M, Lv X, Long J, Yang R, Zhang R, Liu Z, Gu J, Wu P, Wang C
Journal of ethnopharmacology 2024 Mar 1;321:117483
Journal of ethnopharmacology 2024 Mar 1;321:117483
Lysine specific demethylase 1 inhibits sodium arsenite activation of HSCs by regulating SESN2/AMPK/ULK1 signaling pathway activity.
Zhang Y, Tian T, Liang C, Wang J, Zhang J, Tian S, Xie R, Yang T, Han B
Environmental toxicology 2024 Jun;39(6):3563-3577
Environmental toxicology 2024 Jun;39(6):3563-3577
Celastrol enhances the viability of random-pattern skin flaps by regulating autophagy through the AMPK-mTOR-TFEB axis.
Gu M, Li C, Deng Q, Chen X, Lei R
Phytotherapy research : PTR 2024 Jun;38(6):3020-3036
Phytotherapy research : PTR 2024 Jun;38(6):3020-3036
The antidepressant effects of protein arginine methyltransferase 2 involve neuroinflammation.
Liu S, Zhang B, Guo H, Ding Z, Hou W, Hu X, Wang Y, Tan W, Zhou S
Neurochemistry international 2024 Jun;176:105728
Neurochemistry international 2024 Jun;176:105728
Dihydromyricetin regulates KEAP1-Nrf2 pathways to enhance the survival of ischemic flap.
Tao X, Pan X, Zhao G, Xue M, Rui Y
Food science & nutrition 2024 Jun;12(6):3893-3909
Food science & nutrition 2024 Jun;12(6):3893-3909
Experimental verification about treatment of Bu-Shen-Yi-Jing-Fang in Alzheimer's disease by the analysis of the feasible signaling pathway of network pharmacology.
Hu Y, Hao R, Li D, Lu Y, Yu G
BMC complementary medicine and therapies 2024 Jun 8;24(1):222
BMC complementary medicine and therapies 2024 Jun 8;24(1):222
Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal Transition.
Li T, Wei L, Zhang X, Fu B, Zhou Y, Yang M, Cao M, Chen Y, Tan Y, Shi Y, Wu L, Xuan C, Du Q, Hu R
Molecular cancer research : MCR 2024 Jun 4;22(6):538-554
Molecular cancer research : MCR 2024 Jun 4;22(6):538-554
PPIA dictates NRF2 stability to promote lung cancer progression.
Lu W, Cui J, Wang W, Hu Q, Xue Y, Liu X, Gong T, Lu Y, Ma H, Yang X, Feng B, Wang Q, Zhang N, Xu Y, Liu M, Nussinov R, Cheng F, Ji H, Huang J
Nature communications 2024 Jun 3;15(1):4703
Nature communications 2024 Jun 3;15(1):4703
YZL-51N functions as a selective inhibitor of SIRT7 by NAD(+) competition to impede DNA damage repair.
Kang TS, Yan YM, Tian Y, Zhang J, Zhang M, Shu Y, Huang J, He J, Tao CT, Zhu Q, Gu J, Lu X, Cheng YX, Zhu WG
iScience 2024 Jun 21;27(6):110014
iScience 2024 Jun 21;27(6):110014
TERC promotes non-small cell lung cancer progression by facilitating the nuclear localization of TERT.
Sun H, Li X, Long Q, Wang X, Zhu W, Chen E, Zhou W, Yang H, Huang C, Deng W, Chen M
iScience 2024 Jun 21;27(6):109869
iScience 2024 Jun 21;27(6):109869
Low PDE4A expression promoted the progression of ovarian cancer by inducing Snail nuclear translocation.
Wang J, Gu Q, Liu Y, Huang X, Zhang J, Liu B, Li R, Linghu H
Experimental cell research 2024 Jun 15;439(2):114100
Experimental cell research 2024 Jun 15;439(2):114100
Sodium arsenite induces hepatic stellate cells activation by m(6)A modification of TGF-β1 during liver fibrosis.
Qiu T, Hou K, Zhang J, Wang N, Yao X, Yang G, Jiang L, Dong J, Miao M, Bai J, Sun X
Ecotoxicology and environmental safety 2024 Jun 15;278:116435
Ecotoxicology and environmental safety 2024 Jun 15;278:116435
Cell surface CD55 traffics to the nucleus leading to cisplatin resistance and stemness by inducing PRC2 and H3K27 trimethylation on chromatin in ovarian cancer.
Bharti R, Dey G, Khan D, Myers A, Huffman OG, Saygin C, Braley C, Richards E, Sangwan N, Willard B, Lathia JD, Fox PL, Lin F, Jha BK, Brown JM, Yu JS, Dwidar M, Joehlin-Price A, Vargas R, Michener CM, Longworth MS, Reizes O
Molecular cancer 2024 Jun 10;23(1):121
Molecular cancer 2024 Jun 10;23(1):121
GITR exacerbates lysophosphatidylcholine-induced macrophage pyroptosis in sepsis via posttranslational regulation of NLRP3.
Liang S, Zhou J, Cao C, Liu Y, Ming S, Liu X, Shang Y, Lao J, Peng Q, Yang J, Wu M
Cellular & molecular immunology 2024 Jul;21(7):674-688
Cellular & molecular immunology 2024 Jul;21(7):674-688
Platelet-Derived TGF-β1 Promotes Deep Vein Thrombosis.
Zhang S, Li Y, Zhang J, Sun Y, Chu X, Gui X, Tong H, Ding Y, Ju W, Xu M, Li Z, Zeng L, Xu K, Qiao J
Thrombosis and haemostasis 2024 Jul;124(7):641-648
Thrombosis and haemostasis 2024 Jul;124(7):641-648
CircUGGT2 facilitates progression and cisplatin resistance of bladder cancer through nonhomologous end-joining pathway.
Lyu F, Huang S, Yan Z, He Q, Liu C, Cheng L, Cong Y, Chen K, Song Y, Xing Y
Cellular signalling 2024 Jul;119:111164
Cellular signalling 2024 Jul;119:111164
Absence of PD-L1 signaling hinders macrophage defense against Mycobacterium tuberculosis via upregulating STAT3/IL-6 pathway.
Qu P, Li X, Liu W, Zhou F, Xu X, Tang J, Sun M, Li J, Li H, Han Y, Hu C, Lei Y, Pan Q, Zhan L
Microbes and infection 2024 Jul-Aug;26(5-6):105352
Microbes and infection 2024 Jul-Aug;26(5-6):105352
Nuclear translocation of ISG15 regulated by PPP2R2B inhibits cisplatin resistance of bladder cancer.
Huang G, Liu J, Yu A, Luo C, Zhu J, Wang Y, Dai Z, Zhang L, Feng Z, Lu J, Dong Z, Luo J, Chen W, Chen Z
Cellular and molecular life sciences : CMLS 2024 Jul 8;81(1):292
Cellular and molecular life sciences : CMLS 2024 Jul 8;81(1):292
PRMT5-mediated arginine methylation of FXR1 is essential for RNA binding in cancer cells.
Vijayakumar A, Majumder M, Yin S, Brobbey C, Karam J, Howley B, Howe PH, Berto S, Madan LK, Gan W, Palanisamy V
Nucleic acids research 2024 Jul 8;52(12):7225-7244
Nucleic acids research 2024 Jul 8;52(12):7225-7244
Human cytomegalovirus infection impairs neural differentiation via repressing sterol regulatory element binding protein 2-mediated cholesterol biosynthesis.
Li J, Sun J, Xu M, Yang L, Yang N, Deng J, Ma Y, Qi Y, Liu Z, Ruan Q, Liu Y, Huang Y
Cellular and molecular life sciences : CMLS 2024 Jul 6;81(1):289
Cellular and molecular life sciences : CMLS 2024 Jul 6;81(1):289
Puerarin enhances TFEB-mediated autophagy and attenuates ROS-induced pyroptosis after ischemic injury of random-pattern skin flaps.
Lai Y, Yang N, Shi D, Ma X, Huang Y, Lu J, Zhang X, Zhou H, Gao W, Mao C, Wang L
European journal of pharmacology 2024 Jul 5;974:176621
European journal of pharmacology 2024 Jul 5;974:176621
A role for YAP/FOXM1/Nrf2 axis in oxidative stress and apoptosis of cataract induced by UVB irradiation.
Hong Y, Sun Y, Ainiwaer M, Xiao B, Zhang S, Ning L, Zhu X, Ji Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 31;38(14):e23832
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 31;38(14):e23832
Esaxerenone Attenuates Aldosterone-Induced Mitochondrial Damage-Mediated Pyroptosis in Mouse Aorta and Rat Vascular Smooth Muscle Cells.
Xian Y, Wang X, Chang Y, Qiang P, Han Y, Hao J, Gao X, Shimosawa T, Xu Q, Yang F
Life (Basel, Switzerland) 2024 Jul 31;14(8)
Life (Basel, Switzerland) 2024 Jul 31;14(8)
Screening and identification of miRNAs negatively regulating FAM83A/Wnt/β-catenin signaling pathway in non-small cell lung cancer.
Yuan W, Liu W, Huang H, Chen X, Zhang R, Lyu H, Xiao S, Guo D, Zhang Q, Ali DW, Michalak M, Chen XZ, Zhou C, Tang J
Scientific reports 2024 Jul 29;14(1):17394
Scientific reports 2024 Jul 29;14(1):17394
Podophyllotoxin via SIRT1/PPAR /NF-κB axis induced cardiac injury in rats based on the toxicological evidence chain (TEC) concept.
Jiang T, Sun L, Wang Y, Zhang F, Guo J, Sun L, Jiang Y, Xue J, Duan J, Liu C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155655
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155655
METTL1-modulated LSM14A facilitates proliferation and migration in glioblastoma via the stabilization of DDX5.
Wang C, He Y, Fang X, Zhang D, Huang J, Zhao S, Li L, Li G
iScience 2024 Jul 19;27(7):110225
iScience 2024 Jul 19;27(7):110225
TAPI-1 Exhibits Anti-tumor Efficacy in Human Esophageal Squamous Cell Carcinoma Cells via Suppression of NF-κB Signaling Pathway.
Gao L, Li L, Zhang D, Qiu J, Qian J, Liu H
Digestive diseases and sciences 2024 Jan;69(1):81-94
Digestive diseases and sciences 2024 Jan;69(1):81-94
Honokiol Attenuates Choroidal Neovascularization by Inhibiting the Hypoxia-Inducible Factor-α/Vascular Endothelial Growth Factor Axis via Nuclear Transcription Factor-Kappa B Activation.
Pan N, Shi J, Du S, Qiu Z, Ran Q, Guo Y, Ma A, Zhang Q, Sang A, Yang X
Current eye research 2024 Jan;49(1):88-96
Current eye research 2024 Jan;49(1):88-96
New mode of action of curcumin on prostate cancer cells: Modulation of endoplasmic reticulum-associated degradation mechanism and estrogenic signaling.
Erzurumlu Y, Dogan HK, Catakli D
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23636
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23636
CircDYM attenuates microglial apoptosis via CEBPB/ZC3H4 axis in LPS-induced mouse model of depression.
Zhou Z, Ye Q, Ren H, Zhang Y, Han B, Yao H, Bai Y
International journal of biological macromolecules 2024 Jan;254(Pt 3):127922
International journal of biological macromolecules 2024 Jan;254(Pt 3):127922
Lactobacillus species ameliorate membranous nephropathy through inhibiting the aryl hydrocarbon receptor pathway via tryptophan-produced indole metabolites.
Miao H, Wang YN, Yu XY, Zou L, Guo Y, Su W, Liu F, Cao G, Zhao YY
British journal of pharmacology 2024 Jan;181(1):162-179
British journal of pharmacology 2024 Jan;181(1):162-179
SH3RF2 contributes to cisplatin resistance in ovarian cancer cells by promoting RBPMS degradation.
Gong TT, Liu FH, Xiao Q, Li YZ, Wei YF, Xu HL, Cao F, Sun ML, Jiang FL, Tao T, Ma QP, Qin X, Song Y, Gao S, Wu L, Zhao YH, Huang DH, Wu QJ
Communications biology 2024 Jan 9;7(1):67
Communications biology 2024 Jan 9;7(1):67
CLIC3 interacts with NAT10 to inhibit N4-acetylcytidine modification of p21 mRNA and promote bladder cancer progression.
Shuai Y, Zhang H, Liu C, Wang J, Jiang Y, Sun J, Gao X, Bo X, Xiao X, Liao X, Huang C, Chen H, Jiang G
Cell death & disease 2024 Jan 5;15(1):9
Cell death & disease 2024 Jan 5;15(1):9
Knockdown of Smox protects the integrity of the blood-brain barrier through antioxidant effect and Nrf2 pathway activation in stroke.
Wang G, Li Z, Lin P, Zhang H, Wang Y, Zhang T, Wang H, Li H, Lin L, Zhao Y, Jia L, Chen Y, Ji H, Zhao W, Fu Z, Zhong Z
International immunopharmacology 2024 Jan 5;126:111183
International immunopharmacology 2024 Jan 5;126:111183
BCL7A and BCL7B potentiate SWI/SNF-complex-mediated chromatin accessibility to regulate gene expression and vegetative phase transition in plants.
Lei Y, Yu Y, Fu W, Zhu T, Wu C, Zhang Z, Yu Z, Song X, Xu J, Liang Z, Lü P, Li C
Nature communications 2024 Jan 31;15(1):935
Nature communications 2024 Jan 31;15(1):935
Monotropein induces autophagy through activation of the NRF2/PINK axis, thereby alleviating sepsis-induced colonic injury.
Qiang J, Yang R, Li X, Xu X, Zhou M, Ji X, Lu Y, Dong Z
International immunopharmacology 2024 Jan 25;127:111432
International immunopharmacology 2024 Jan 25;127:111432
Mesencephalic astrocyte-derived neurotrophic factor (MANF) alleviates cerebral ischemia/reperfusion injury in mice by regulating microglia polarization via A20/NF-κB pathway.
Zhao X, Wang Z, Wang J, Xu F, Zhang Y, Han D, Fang W
International immunopharmacology 2024 Jan 25;127:111396
International immunopharmacology 2024 Jan 25;127:111396
LRP11 promotes stem-like T cells via MAPK13-mediated TCF1 phosphorylation, enhancing anti-PD1 immunotherapy.
Sun L, Ma Z, Zhao X, Tan X, Tu Y, Wang J, Chen L, Chen Z, Chen G, Lan P
Journal for immunotherapy of cancer 2024 Jan 25;12(1)
Journal for immunotherapy of cancer 2024 Jan 25;12(1)
MiR-31-5p regulates the neuroinflammatory response via TRAF6 in neuropathic pain.
Liu Y, Wang L, Zhou C, Yuan Y, Fang B, Lu K, Xu F, Chen L, Huang L
Biology direct 2024 Jan 24;19(1):10
Biology direct 2024 Jan 24;19(1):10
YAP represses intestinal inflammation through epigenetic silencing of JMJD3.
Zhu H, Lu J, Fu M, Chen P, Yu Y, Chen M, Zhao Q, Wu M, Ye M
Clinical epigenetics 2024 Jan 20;16(1):14
Clinical epigenetics 2024 Jan 20;16(1):14
The SOX4/EZH2/SLC7A11 signaling axis mediates ferroptosis in calcium oxalate crystal deposition-induced kidney injury.
Yan X, Xia Y, Li B, Ye Z, Li L, Yuan T, Song B, Yu W, Rao T, Ning J, Lin F, Mei S, Mao Z, Zhou X, Li W, Cheng F
Journal of translational medicine 2024 Jan 2;22(1):9
Journal of translational medicine 2024 Jan 2;22(1):9
Metabolic regulation of homologous recombination repair by MRE11 lactylation.
Chen Y, Wu J, Zhai L, Zhang T, Yin H, Gao H, Zhao F, Wang Z, Yang X, Jin M, Huang B, Ding X, Li R, Yang J, He Y, Wang Q, Wang W, Kloeber JA, Li Y, Hao B, Zhang Y, Wang J, Tan M, Li K, Wang P, Lou Z, Yuan J
Cell 2024 Jan 18;187(2):294-311.e21
Cell 2024 Jan 18;187(2):294-311.e21
The P286R mutation of DNA polymerase ε activates cancer-cell-intrinsic immunity and suppresses endometrial tumorigenesis via the cGAS-STING pathway.
Tang M, Yin S, Zeng H, Huang A, Huang Y, Hu Z, Shah AR, Zhang S, Li H, Chen G
Cell death & disease 2024 Jan 18;15(1):69
Cell death & disease 2024 Jan 18;15(1):69
Ochratoxin A-enhanced glycolysis induces inflammatory responses in human gastric epithelium cells through mTOR/HIF-1α signaling pathway.
Wang Y, Zhao M, Cui J, Lian H, Hao Z, Lou L, Jia X, Zhao W, Shen H, Xing L, Zhang X
Ecotoxicology and environmental safety 2024 Jan 15;270:115868
Ecotoxicology and environmental safety 2024 Jan 15;270:115868
Celastrol-loaded bovine serum albumin nanoparticles target inflamed neutrophils for improved rheumatoid arthritis therapy.
Liu S, Liu M, Xiu J, Zhang T, Zhang B, Cun D, Yang C, Li K, Zhang J, Zhao X
Acta biomaterialia 2024 Jan 15;174:345-357
Acta biomaterialia 2024 Jan 15;174:345-357
Amyloid aggregates induced by the p53-R280T mutation lead to loss of p53 function in nasopharyngeal carcinoma.
Li J, Guo M, Chen L, Chen Z, Fu Y, Chen Y
Cell death & disease 2024 Jan 11;15(1):35
Cell death & disease 2024 Jan 11;15(1):35
ALA-PDT promotes the death and contractile capacity of hypertrophic scar fibroblasts through inhibiting the TGF-β1/Smad2/3/4 signaling pathway.
Qu Z, Chen Y, Du K, Qiao J, Chen L, Chen J, Wei L
Photodiagnosis and photodynamic therapy 2024 Feb;45:103915
Photodiagnosis and photodynamic therapy 2024 Feb;45:103915
Targeting CD38/ ADP-ribosyl cyclase as a novel therapeutic strategy for identification of three potent agonists for leukopenia treatment.
Liu Y, Zhang L, Wang L, Tang X, Wan S, Huang Q, Ran M, Shen H, Yang Y, Chiampanichayakul S, Tima S, Anuchapreeda S, Wu J
Pharmacological research 2024 Feb;200:107068
Pharmacological research 2024 Feb;200:107068
Inhibition of SIRT7 promotes STAT1 activation and STAT1-dependent signaling in hepatocellular carcinoma.
Dong L, Wei X, Yu L, Li Y, Chen L
Cellular signalling 2024 Feb;114:111005
Cellular signalling 2024 Feb;114:111005
The Interplay Between HIF-1α and EZH2 in Lung Cancer and Dual-Targeted Drug Therapy.
Wang J, Yang C, Xu H, Fan X, Jia L, Du Y, Liu S, Wang W, Zhang J, Zhang Y, Wang X, Liu Z, Bao J, Li S, Yang J, Wu C, Tang J, Chen G, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2303904
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2303904
Epigenetic drug screening for trophoblast syncytialization reveals a novel role for MLL1 in regulating fetoplacental growth.
Wu J, Qin C, Tian F, Liu X, Hu J, Wu F, Chen C, Lin Y
BMC medicine 2024 Feb 5;22(1):57
BMC medicine 2024 Feb 5;22(1):57
Altered nuclear envelope homeostasis is a key pathogenic event in C9ORF72-linked ALS/FTD.
Sirtori R, Gregoire M, Collins A, Santangelo S, Chatragadda B, Cullen R, Ratti A, Fallini C
bioRxiv : the preprint server for biology 2024 Feb 4;
bioRxiv : the preprint server for biology 2024 Feb 4;
Rosavin Alleviates LPS-Induced Acute Lung Injure by Modulating the TLR-4/NF-κB/MAPK Singnaling Pathways.
Liu QH, Zhang K, Feng SS, Zhang LJ, Li SY, Wang HY, Wang JH
International journal of molecular sciences 2024 Feb 3;25(3)
International journal of molecular sciences 2024 Feb 3;25(3)
YTHDF2-mediated circYAP1 drives immune escape and cancer progression through activating YAP1/TCF4-PD-L1 axis.
Chen Z, Wang W, Hu S, Sun H, Chen C, Zhang Z, Sun X, Jia B, Hu J, Wang C, Liu Y, Sun Z
iScience 2024 Feb 16;27(2):108779
iScience 2024 Feb 16;27(2):108779
Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers.
Liu C, Chen L, Cong Y, Cheng L, Shuai Y, Lv F, Chen K, Song Y, Xing Y
Cell death & disease 2024 Feb 16;15(2):149
Cell death & disease 2024 Feb 16;15(2):149
Eriocalyxin B alleviated ischemic cerebral injury by limiting microglia-mediated excessive neuroinflammation in mice.
Chen Y, Zhang C, Zhao L, Chen R, Zhang P, Li J, Zhang X, Zhang X
Experimental animals 2024 Feb 14;73(1):124-135
Experimental animals 2024 Feb 14;73(1):124-135
MAPRE3 as an epigenetic target of EZH2 restricts ovarian cancer proliferation in vitro and in vivo.
Zhang Y, Liu F, Zheng J, Jiang K, Ai H, Liu L, Mao D
Experimental cell research 2024 Feb 1;435(1):113913
Experimental cell research 2024 Feb 1;435(1):113913
Salivary-secreted vitellogenin suppresses H(2)O(2) burst of plants facilitating Recilia dorsalis leafhopper feeding.
Lu C, Zhang Y, Xu Y, Wei T, Chen Q
Pest management science 2024 Dec;80(12):6222-6235
Pest management science 2024 Dec;80(12):6222-6235
Insulin-Like Growth Factor-Binding Protein 5 Promotes the Cell Proliferation and Osteogenic Potential of Dental Pulp Stem Cells Dependent on Its Nuclear Localisation Sequence.
Sun Z, Li J, Liu H, Fan Z
Journal of oral rehabilitation 2024 Dec;51(12):2664-2674
Journal of oral rehabilitation 2024 Dec;51(12):2664-2674
Targeting CA9 restricts pancreatic cancer progression through pH regulation and ROS production.
Yang J, Tong X, Wang W, Yu X, Xu J, Shi S
Cellular oncology (Dordrecht, Netherlands) 2024 Dec;47(6):2367-2382
Cellular oncology (Dordrecht, Netherlands) 2024 Dec;47(6):2367-2382
SETD2 deficiency in peripheral sensory neurons induces allodynia by promoting NMDA receptor expression through NFAT5 in rodent models.
Chen G, Gu P, Wu W, Yin Y, Pan L, Huang S, Lin W, Deng M
International journal of biological macromolecules 2024 Dec;282(Pt 5):136767
International journal of biological macromolecules 2024 Dec;282(Pt 5):136767
New TIPARP inhibitor rescues mitochondrial function and brain injury in ischemic stroke.
Cai Y, Gu H, Li L, Liu X, Bai Y, Shen L, Han B, Xu Y, Yao H
Pharmacological research 2024 Dec;210:107508
Pharmacological research 2024 Dec;210:107508
TRPV4-β-catenin axis is a novel therapeutic target for dry skin-induced chronic itch.
Tang Y, Zhou Y, Ren J, Wang Y, Li X, Qi M, Yang Y, Zhu C, Wang C, Ma Y, Tang Z, Yu G
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167491
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167491
Design, synthesis, and biological evaluation of novel AAK1/HDACs dual inhibitors against SARS-CoV-2 entry.
Mao ND, Xu Y, Yao X, Gao Y, Hui Z, Che H, Wang C, Lu J, Yu J, Hu S, Zhang H, Ye XY
Bioorganic chemistry 2024 Dec;153:107973
Bioorganic chemistry 2024 Dec;153:107973
Key role of PPAR-γ-mediated suppression of the NFκB signaling pathway in rutin's antidepressant effect.
Yin SY, Shao XX, Shen SY, Zhang JR, Shen ZQ, Liang LF, Chen C, Yue N, Fu XJ, Yu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156178
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156178
4-Hydroxydictyolactone alleviates cerebral ischemia injury by regulating neuroinflammation and autophagy via AMPK signaling pathway.
Qi Y, Zhu H, Chen Y, Zhang Y, Jin S, Xu X, Ma X, Chen L, Zhao M, Zhu H, Yan P
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156157
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156157
Obacunone improves dihydrotestosterone-induced androgen alopecia by inhibiting androgen receptor dimerization.
Liu J, Chen S, Yan W, Liu J, Jin Q, Zhang Y, Zhang F, Pan Y, Hu W, Jin L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156042
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156042
Adropin regulates macrophage phenotype via PPARγ signalling: A preliminary study of adropin and Crohn's disease.
Zeng L, Chen J, Xie H, Liu W, Wang C
Scandinavian journal of immunology 2024 Dec;100(6):e13415
Scandinavian journal of immunology 2024 Dec;100(6):e13415
The miR-6240 target gene Igf2bp3 promotes myoblast fusion by enhancing myomaker mRNA stability.
Huang Y, Wang W, Fan X, Liu X, Liu W, Wang Z, Li Y, Yang Y, Tang Z
Cellular & molecular biology letters 2024 Dec 5;29(1):152
Cellular & molecular biology letters 2024 Dec 5;29(1):152
Monotropein alleviates septic acute liver injury by restricting oxidative stress, inflammation, and apoptosis via the AKT (Ser473)/GSK3β (Ser9)/Fyn/NRF2 pathway.
Xie K, Wang F, Yang Y, Pan S, Wang J, Xiao N, Wang X, Ma Z, Xu X, Dong Z
International immunopharmacology 2024 Dec 5;142(Pt B):113178
International immunopharmacology 2024 Dec 5;142(Pt B):113178
Palmatine attenuates MYH9 mediated nuclear localization of AURKA to induce G2/M phase arrest in colorectal cancer cells.
Tang W, Li J, Zhou Y, Li J, Ma Z, Li X, Wang H, Xiong M, Chen X, Li X, Chen W, Ma H, Ye X
International immunopharmacology 2024 Dec 25;143(Pt 3):113615
International immunopharmacology 2024 Dec 25;143(Pt 3):113615
Neuregulin-1 reduces Doxorubicin-induced cardiotoxicity by upregulating YAP to inhibit senescence.
Shi H, Zou Y, Li Y, Li Y, Liu B
International immunopharmacology 2024 Dec 25;143(Pt 1):113278
International immunopharmacology 2024 Dec 25;143(Pt 1):113278
Mutation on JmjC domain of UTX impaired its antitumor effects in pancreatic cancer via inhibiting G0S2 expression and activating the Toll-like signaling pathway.
Shen XH, Xiong SP, Wang SP, Lu S, Wan YY, Zhang HQ
Molecular medicine (Cambridge, Mass.) 2024 Dec 20;30(1):258
Molecular medicine (Cambridge, Mass.) 2024 Dec 20;30(1):258
Targeting TRAF6/IRF3 axis to inhibit NF-κB-p65 nuclear translocation enhances the chemosensitivity of 5-FU and reverses the proliferation of gastric cancer.
Chen S, Zhang D, Du Y, Shi J, Gu S, Zhou X, Yu H, Wang F, Chen J, Cui H
Cell death & disease 2024 Dec 20;15(12):924
Cell death & disease 2024 Dec 20;15(12):924
Lactate Dehydrogenase Inhibition Protects against Hepatic Fibrosis by Regulating Metabolic Reprogramming of Hepatic Stellate Cells.
Li L, Lei Q, Zhen Y, Cao L, Dong Y, Liu X, Wang M
Journal of agricultural and food chemistry 2024 Dec 18;72(50):27953-27964
Journal of agricultural and food chemistry 2024 Dec 18;72(50):27953-27964
myCAF-derived exosomal PWAR6 accelerates CRC liver metastasis via altering glutamine availability and NK cell function in the tumor microenvironment.
Fang H, Dai W, Gu R, Zhang Y, Li J, Luo W, Tong S, Han L, Wang Y, Jiang C, Wang X, Wang R, Cai G
Journal of hematology & oncology 2024 Dec 18;17(1):126
Journal of hematology & oncology 2024 Dec 18;17(1):126
RRM1 promotes homologous recombination and radio/chemo-sensitivity via enhancing USP11 and E2F1-mediated RAD51AP1 transcription.
Yang S, Wang R, Liu L, Xu F, Zhao X, Yao Z, Zhang J, Cheng X, Xu A, Wu L, Zhao G
Cell death discovery 2024 Dec 18;10(1):496
Cell death discovery 2024 Dec 18;10(1):496
Soyasaponin Bb/Gelatin-Methacryloyl Hydrogel for Cartilage Inflammation Inhibition.
Jiang Y, Li T, Liu B, Tian Y, Wang Y, Li T, Zhang D
ACS omega 2024 Dec 17;9(50):49597-49608
ACS omega 2024 Dec 17;9(50):49597-49608
Pharmacodynamic insights into maresin 1: Enhancing flap viability via the keap1/Nrf2 axis to control ROS-driven apoptosis and ferroptosis.
Fang P, Cheng S, Lai Y, Ma X, Lu K, Lu J, Li G, Yang E, Yang N, Gao W, Jiang R
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2024 Dec 1;203:106923
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2024 Dec 1;203:106923
Downregulation of chemoresistance by claudin-14 silencing in human colorectal cancer cells.
Mizukami Y, Ito A, Hashimoto S, Ando T, Ishikawa Y, Eguchi H, Yoshino Y, Matsunaga T, Ikari A
Archives of biochemistry and biophysics 2024 Aug;758:110075
Archives of biochemistry and biophysics 2024 Aug;758:110075
Sweroside alleviates pressure overload-induced heart failure through targeting CaMKⅡδ to inhibit ROS-mediated NF-κB/NLRP3 in cardiomyocytes.
Wang D, Yu X, Gao K, Li F, Li X, Pu H, Zhang P, Guo S, Wang W
Redox biology 2024 Aug;74:103223
Redox biology 2024 Aug;74:103223
Curcumin inhibits PAT-induced renal ferroptosis via the p62/Keap1/Nrf2 signalling pathway.
Zhai J, Chen Z, Zhu Q, Guo Z, Sun X, Jiang L, Li J, Wang N, Yao X, Zhang C, Deng H, Wang S, Yang G
Toxicology 2024 Aug;506:153863
Toxicology 2024 Aug;506:153863
CRHR1 antagonist alleviated depression-like behavior by downregulating p62 in a rat model of post-stroke depression.
Liu H, Zhang Y, Hou X, Zhu C, Yang Q, Li K, Fan L, Zhang X, Jiang X, Jin X, Lei H, Chen T, Zhang F, Zhang Z, Song J
Experimental neurology 2024 Aug;378:114822
Experimental neurology 2024 Aug;378:114822
Nrf2 activation by pyrroloquinoline quinone inhibits natural aging-related intervertebral disk degeneration in mice.
Xue Q, Li J, Qin R, Li M, Li Y, Zhang J, Wang R, Goltzman D, Miao D, Yang R
Aging cell 2024 Aug;23(8):e14202
Aging cell 2024 Aug;23(8):e14202
Ubiquitin-specific peptidase 15 regulates the TFAP4/PCGF1 axis facilitating liver metastasis of colorectal cancer and cell stemness.
Yin H, Wu D, Qu Q, Li Z, Zhao L
Biochemical pharmacology 2024 Aug;226:116319
Biochemical pharmacology 2024 Aug;226:116319
Extracellular vesicles miR-31-5p promotes pancreatic cancer chemoresistance via regulating LATS2-Hippo pathway and promoting SPARC secretion from pancreatic stellate cells.
Qin C, Zhao B, Wang Y, Li Z, Li T, Zhao Y, Wang W, Zhao Y
Journal of extracellular vesicles 2024 Aug;13(8):e12488
Journal of extracellular vesicles 2024 Aug;13(8):e12488
The Compromised Fanconi Anemia Pathway in Prelamin A-Expressing Cells Contributes to Replication Stress-Induced Genomic Instability.
Nie P, Zhang C, Wu F, Chen S, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2307751
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2307751
Insect ribosome-rescuer Pelo-Hbs1 complex on sperm surface mediates paternal arbovirus transmission.
Sun X, Du Y, Cheng Y, Guan W, Li Y, Chen H, Jia D, Wei T
Nature communications 2024 Aug 9;15(1):6817
Nature communications 2024 Aug 9;15(1):6817
Discovery of Potent and Selective G9a Degraders for the Treatment of Pancreatic Cancer.
Shi Y, Shen Q, Long R, Mao Y, Tong S, Yang Y, Gao J, Zhou H, Chen Y, Zhou B
Journal of medicinal chemistry 2024 Aug 8;67(15):13271-13285
Journal of medicinal chemistry 2024 Aug 8;67(15):13271-13285
The extracellular matrix integrates mitochondrial homeostasis.
Zhang H, Tsui CK, Garcia G, Joe LK, Wu H, Maruichi A, Fan W, Pandovski S, Yoon PH, Webster BM, Durieux J, Frankino PA, Higuchi-Sanabria R, Dillin A
Cell 2024 Aug 8;187(16):4289-4304.e26
Cell 2024 Aug 8;187(16):4289-4304.e26
The WDR11 complex is a receptor for acidic-cluster-containing cargo proteins.
Deng H, Jia G, Li P, Tang Y, Zhao L, Yang Q, Zhao J, Wang J, Tu Y, Yong X, Zhang S, Mo X, Billadeau DD, Su Z, Jia D
Cell 2024 Aug 8;187(16):4272-4288.e20
Cell 2024 Aug 8;187(16):4272-4288.e20
Mechanism of ASF1 Inhibition by CDAN1.
Sedor SF, Shao S
bioRxiv : the preprint server for biology 2024 Aug 8;
bioRxiv : the preprint server for biology 2024 Aug 8;
Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer.
Jiang Y, Wang Y, Chen G, Sun F, Wu Q, Huang Q, Zeng D, Qiu W, Wang J, Yao Z, Liang B, Li S, Wu J, Huang N, Wang Y, Chen J, Zhai X, Huang L, Xu B, Yamamoto M, Tsukamoto T, Nomura S, Liao W, Shi M
Cell metabolism 2024 Aug 6;36(8):1806-1822.e11
Cell metabolism 2024 Aug 6;36(8):1806-1822.e11
PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson's disease.
Cao B, Chen X, Li Y, Zhou T, Chen N, Guo Y, Zhao M, Guo C, Shi Y, Wang Q, Du X, Zhang L, Li Y
NPJ Parkinson's disease 2024 Aug 6;10(1):146
NPJ Parkinson's disease 2024 Aug 6;10(1):146
KAT7 serves as an oncogenic gene and regulates CCL3 expression via STAT1 signaling in osteosarcoma.
Yuan Q, Wu Y, Xue C, Zhao D, Wang H, Shen Y
Biochemical and biophysical research communications 2024 Aug 30;722:150156
Biochemical and biophysical research communications 2024 Aug 30;722:150156
Cryptotanshinone alleviates liver fibrosis via inhibiting STAT3/CPT1A-dependent fatty acid oxidation in hepatic stellate cells.
Li Z, Zheng Y, Zhang L, Xu E
Chemico-biological interactions 2024 Aug 25;399:111119
Chemico-biological interactions 2024 Aug 25;399:111119
Discovery of Novel Imidazo[1,2-a]pyridine-Based HDAC6 Inhibitors as an Anticarcinogen with a Cardioprotective Effect.
Yang FF, Liu JJ, Xu XL, Hu T, Liu JQ, He ZX, Zhao GY, Wei B, Ma LY
Journal of medicinal chemistry 2024 Aug 22;67(16):14345-14369
Journal of medicinal chemistry 2024 Aug 22;67(16):14345-14369
Two-polarized roles of transcription factor FOSB in lung cancer progression and prognosis: dependent on p53 status.
Zhang H, Zhang G, Xiao M, Cui S, Jin C, Yang J, Wu S, Lu X
Journal of experimental & clinical cancer research : CR 2024 Aug 21;43(1):237
Journal of experimental & clinical cancer research : CR 2024 Aug 21;43(1):237
The cellular Notch1 protein promotes KSHV reactivation in an Rta-dependent manner.
DeCotiis-Mauro J, Han SM, Mello H, Goyeneche C, Marchesini-Tovar G, Jin L, Bellofatto V, Lukac DM
Journal of virology 2024 Aug 20;98(8):e0078824
Journal of virology 2024 Aug 20;98(8):e0078824
Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damage.
Kan T, Li H, Hou L, Cui J, Wang Y, Sun L, Wang L, Yan M, Yu Z
iScience 2024 Aug 16;27(8):110507
iScience 2024 Aug 16;27(8):110507
CDK4/6 Alters TBK1 Phosphorylation to Inhibit the STING Signaling Pathway in Prostate Cancer.
Li W, Guo F, Zeng R, Liang H, Wang Y, Xiong W, Wu H, Yang C, Jin X
Cancer research 2024 Aug 15;84(16):2588-2606
Cancer research 2024 Aug 15;84(16):2588-2606
Regulation of Hippo/YAP axis in colon cancer progression by the deubiquitinase JOSD1.
Sun Y, Liu D, Zhang X, Su P, Li X, Li Z, Gai Y, Li J, Yang Z, Ding Y, Zhu J, Tan X
Cell death discovery 2024 Aug 14;10(1):365
Cell death discovery 2024 Aug 14;10(1):365
Revealing the mechanism of ethyl acetate extracts of Semen Impatientis against prostate cancer based on network pharmacology and transcriptomics.
Hu B, Wang C, Wu Y, Han C, Liu J, Chen R, Wang T
Journal of ethnopharmacology 2024 Aug 10;330:118228
Journal of ethnopharmacology 2024 Aug 10;330:118228
Hypoxia conduces the glioma progression by inducing M2 macrophage polarization via elevating TNFSF9 level in a histone-lactylation-dependent manner.
Li M, Sun P, Tu B, Deng G, Li D, He W
American journal of physiology. Cell physiology 2024 Aug 1;327(2):C487-C504
American journal of physiology. Cell physiology 2024 Aug 1;327(2):C487-C504
CUDC-907 exhibits potent antitumor effects against ovarian cancer through multiple in vivo and in vitro mechanisms.
Wang Y, Wen J, Sun X, Sun Y, Liu Y, Cheng X, Wu W, Liu Q, Ren F
Cancer chemotherapy and pharmacology 2024 Apr;93(4):295-306
Cancer chemotherapy and pharmacology 2024 Apr;93(4):295-306
A novel 2-iminobenzimidazole compound, XYA1353, displays in vitro and in vivo anti-myeloma activity via targeting NF-κB signaling.
Gao J, Zhou J, Zhang M, Zhang Y, Zeng Y, Li S, Xu K, Yao R
Molecular and cellular biochemistry 2024 Apr;479(4):843-857
Molecular and cellular biochemistry 2024 Apr;479(4):843-857
STING deficiency alleviates ferroptosis through FPN1 stabilization in diabetic kidney disease.
Zhao QX, Yan SB, Wang F, Li XX, Shang GK, Zheng ZJ, Xiao J, Lin ZW, Li CB, Ji XP
Biochemical pharmacology 2024 Apr;222:116102
Biochemical pharmacology 2024 Apr;222:116102
A snake cathelicidin enhances transcription factor EB-mediated autophagy and alleviates ROS-induced pyroptosis after ischaemia-reperfusion injury of island skin flaps.
Yang N, Yu G, Lai Y, Zhao J, Chen Z, Chen L, Fu Y, Fang P, Gao W, Cai Y, Li Z, Xiao J, Zhou K, Ding J
British journal of pharmacology 2024 Apr;181(7):1068-1090
British journal of pharmacology 2024 Apr;181(7):1068-1090
Genetically encoded bioorthogonal tryptophan decaging in living cells.
Zhu Y, Ding W, Chen Y, Shan Y, Liu C, Fan X, Lin S, Chen PR
Nature chemistry 2024 Apr;16(4):533-542
Nature chemistry 2024 Apr;16(4):533-542
Mitochondrial dysfunction induced by HIF-1α under hypoxia contributes to the development of gastric mucosal lesions.
Xiao Y, Liu X, Xie K, Luo J, Zhang Y, Huang X, Luo J, Tan S
Clinical and translational medicine 2024 Apr;14(4):e1653
Clinical and translational medicine 2024 Apr;14(4):e1653
The BAS chromatin remodeler determines brassinosteroid-induced transcriptional activation and plant growth in Arabidopsis.
Zhu T, Wei C, Yu Y, Zhang Z, Zhu J, Liang Z, Song X, Fu W, Cui Y, Wang ZY, Li C
Developmental cell 2024 Apr 8;59(7):924-939.e6
Developmental cell 2024 Apr 8;59(7):924-939.e6
Rewiring of a KNOXI regulatory network mediated by UFO underlies the compound leaf development in Medicago truncatula.
Lu Z, Zhang J, Wang H, Zhang K, Gu Z, Xu Y, Zhang J, Wang M, Han L, Xiang F, Zhou C
Nature communications 2024 Apr 6;15(1):2988
Nature communications 2024 Apr 6;15(1):2988
Neuroprotective effects of takinib on an experimental traumatic brain injury rat model via inhibition of transforming growth factor beta-activated kinase 1.
Hao S, Yuan S, Liu Z, Hou B, Feng S, Zhang D
Heliyon 2024 Apr 30;10(8):e29484
Heliyon 2024 Apr 30;10(8):e29484
Diphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects.
Shi Y, Huang D, Song C, Cao R, Wang Z, Wang D, Zhao L, Xu X, Lu C, Xiong F, Zhao H, Li S, Zhou Q, Luo S, Hu D, Zhang Y, Wang C, Shen Y, Su W, Wu Y, Schmitz K, Wei S, Song W
Nature communications 2024 Apr 26;15(1):3301
Nature communications 2024 Apr 26;15(1):3301
Ginsenoside Rg1 attenuates lipopolysaccharide-induced chronic liver damage by activating Nrf2 signaling and inhibiting inflammasomes in hepatic cells.
Zhou H, Liu Y, Su Y, Ji P, Kong L, Sun R, Zhang D, Xu H, Li W, Li W
Journal of ethnopharmacology 2024 Apr 24;324:117794
Journal of ethnopharmacology 2024 Apr 24;324:117794
hnRNPU is required for spermatogonial stem cell pool establishment in mice.
Wen Y, Zhou S, Gui Y, Li Z, Yin L, Xu W, Feng S, Ma X, Gan S, Xiong M, Dong J, Cheng K, Wang X, Yuan S
Cell reports 2024 Apr 23;43(4):114113
Cell reports 2024 Apr 23;43(4):114113
Depletion of Mettl3 in cholinergic neurons causes adult-onset neuromuscular degeneration.
Dermentzaki G, Furlan M, Tanaka I, Leonardi T, Rinchetti P, Passos PMS, Bastos A, Ayala YM, Hanna JH, Przedborski S, Bonanomi D, Pelizzola M, Lotti F
Cell reports 2024 Apr 23;43(4):113999
Cell reports 2024 Apr 23;43(4):113999
Interaction with B-type lamin reveals the function of Drosophila Keap1 xenobiotic response factor in nuclear architecture.
Carlson J, Neidviecky E, Cook I, Cross B, Deng H
Molecular biology reports 2024 Apr 20;51(1):556
Molecular biology reports 2024 Apr 20;51(1):556
Urolithin B reduces cartilage degeneration and alleviates osteoarthritis by inhibiting inflammation.
Xue H, Zhou H, Lou Q, Yuan P, Feng Z, Qiao L, Zhang J, Xie H, Shen Y, Ma Q, Wang S, Zhang B, Ye H, Cheng J, Sun X, Shi P
Food & function 2024 Apr 2;15(7):3552-3565
Food & function 2024 Apr 2;15(7):3552-3565
Inhibition of autophagy-related protein 7 enhances anti-tumor immune response and improves efficacy of immune checkpoint blockade in microsatellite instability colorectal cancer.
Zhang W, Chen L, Liu J, Chen B, Shi H, Chen H, Qi H, Wu Z, Mao X, Wang X, Huang Y, Li J, Yu Z, Zhong M, Wang T, Li Q
Journal of experimental & clinical cancer research : CR 2024 Apr 16;43(1):114
Journal of experimental & clinical cancer research : CR 2024 Apr 16;43(1):114
Fosl2 Deficiency Predisposes Mice to Osteopetrosis, Leading to Bone Marrow Failure.
Chen J, Wen Y, Lin L, Cui Y, Chen Z, Gao J, Zhuang Y, Chen Q
Journal of immunology (Baltimore, Md. : 1950) 2024 Apr 1;212(7):1081-1093
Journal of immunology (Baltimore, Md. : 1950) 2024 Apr 1;212(7):1081-1093
Baicalin Ameliorates Lung Injury in Rats by Inhibiting NLRP3 Inflammasome Activation via NF-[Formula: see text]B Signaling Pathway.
Yang X, Han J, Huan Z, Xu C, Wang Q, Ge X
The American journal of Chinese medicine 2023;51(4):979-996
The American journal of Chinese medicine 2023;51(4):979-996
Maslinic Acid Ameliorates Myocardial Ischemia Reperfusion Injury-Induced Oxidative Stress via Activating Nrf2 and Inhibiting NF-[Formula: see text]B Pathways.
Li Q, Li Z, Liu C, Xu M, Li T, Wang Y, Feng J, Yin X, Du X, Lu C
The American journal of Chinese medicine 2023;51(4):929-951
The American journal of Chinese medicine 2023;51(4):929-951
Identification of the H3K36me3 reader LEDGF/p75 in the pancancer landscape and functional exploration in clear cell renal cell carcinoma.
Zhang Y, Guo W, Feng Y, Yang L, Lin H, Zhou P, Zhao K, Jiang L, Yao B, Feng N
Computational and structural biotechnology journal 2023;21:4134-4148
Computational and structural biotechnology journal 2023;21:4134-4148
ESRG is critical to maintain the cell survival and self-renewal/pluripotency of hPSCs by collaborating with MCM2 to suppress p53 pathway.
Li S, Liu H, Liu W, Shi N, Zhao M, Wanggou S, Luo W, Wang L, Zhu B, Zuo X, Xie W, Zhao C, Zhou Y, Luo L, Gao X, Jiang X, Ren C
International journal of biological sciences 2023;19(3):916-935
International journal of biological sciences 2023;19(3):916-935
Low expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis.
Wang X, Chen Q, Bing Z, Zhou S, Xu Z, Hou Y, Zhao Y, Zhao S, Wang T
International journal of biological sciences 2023;19(14):4672-4688
International journal of biological sciences 2023;19(14):4672-4688
FGF2 Alleviates Microvascular Ischemia-Reperfusion Injury by KLF2-mediated Ferroptosis Inhibition and Antioxidant Responses.
Chen F, Zhan J, Liu M, Mamun AA, Huang S, Tao Y, Zhao J, Zhang Y, Xu Y, He Z, Du S, Lu W, Li X, Chen Z, Xiao J
International journal of biological sciences 2023;19(13):4340-4359
International journal of biological sciences 2023;19(13):4340-4359
Glycolysis mediates neuron specific histone acetylation in valproic acid-induced human excitatory neuron differentiation.
Chen A, Wang M, Xu C, Zhao Y, Xian P, Li Y, Zheng W, Yi X, Wu S, Wang Y
Frontiers in molecular neuroscience 2023;16:1151162
Frontiers in molecular neuroscience 2023;16:1151162
Inhibition of Non-small Cell Lung Cancer by Ferroptosis and Apoptosis Induction through P53 and GSK-3β/Nrf2 Signal Pathways using Qingrehuoxue Formula.
Xu F, Zhang J, Ji L, Cui W, Cui J, Tang Z, Sun N, Zhang G, Guo M, Liu B, Dong J
Journal of Cancer 2023;14(3):336-349
Journal of Cancer 2023;14(3):336-349
IL-37 counteracts inflammatory injury in the temporomandibular joint via the intracellular pathway.
Li J, Peng S, Yan Y, Yan S, Cao X, Li Y, Zhu L, Xu J
Frontiers in pharmacology 2023;14:1250216
Frontiers in pharmacology 2023;14:1250216
ALDH2 attenuates myocardial pyroptosis through breaking down Mitochondrion-NLRP3 inflammasome pathway in septic shock.
Zhang Y, Lv Y, Zhang Q, Wang X, Han Q, Liang Y, He S, Yuan Q, Zheng J, Xu C, Zhang X, Wang Z, Yu H, Xue L, Wang J, Xu F, Pang J, Chen Y
Frontiers in pharmacology 2023;14:1125866
Frontiers in pharmacology 2023;14:1125866
Histone H3K27 methyltransferase EZH2 regulates apoptotic and inflammatory responses in sepsis-induced AKI.
Li B, Xia Y, Mei S, Ye Z, Song B, Yan X, Lin F, Rao T, Yu W, Mei C, Lv J, Wu M, Mao Z, Zhou X, Cheng F
Theranostics 2023;13(6):1860-1875
Theranostics 2023;13(6):1860-1875
Development of triazole-based PKC-inhibitors to overcome resistance to EGFR inhibitors in EGFR-mutant lung cancers.
Lee PC, Kumar V, Sivakumar G, Tseng TY, Li YC, Jiang YC, Hsiao YC, Lin HW, Chang CS, Hung MC
American journal of cancer research 2023;13(10):4693-4707
American journal of cancer research 2023;13(10):4693-4707
DOT1L promotes cell proliferation and invasion by epigenetically regulating STAT5B in renal cell carcinoma.
Hou Y, Huang S, Liu J, Wang L, Yuan Y, Liu H, Weng X, Chen Z, Hu J, Liu X
American journal of cancer research 2023;13(1):276-292
American journal of cancer research 2023;13(1):276-292
Lysine methylation of PPP1CA by the methyltransferase SUV39H2 disrupts TFEB-dependent autophagy and promotes intervertebral disc degeneration.
Liang H, Luo R, Li G, Zhang W, Zhu D, Wu D, Zhou X, Tong B, Wang B, Feng X, Wang K, Song Y, Yang C
Cell death and differentiation 2023 Sep;30(9):2135-2150
Cell death and differentiation 2023 Sep;30(9):2135-2150
Ghrelin promotes cardiomyocyte differentiation of adipose tissue‑derived mesenchymal stem cells by DDX17‑mediated regulation of the SFRP4/Wnt/β‑catenin axis.
Liu GB, Cheng YX, Li HM, Liu Y, Sun LX, Wu Q, Guo SF, Li TT, Dong CL, Sun G
Molecular medicine reports 2023 Sep;28(3)
Molecular medicine reports 2023 Sep;28(3)
Pan-cancer integrated bioinformatic analysis of RNA polymerase subunits reveal RNA Pol I member CD3EAP regulates cell growth by modulating autophagy.
Bhandari N, Acharya D, Chatterjee A, Mandve L, Kumar P, Pratap S, Malakar P, Shukla SK
Cell cycle (Georgetown, Tex.) 2023 Sep;22(18):1986-2002
Cell cycle (Georgetown, Tex.) 2023 Sep;22(18):1986-2002
Estrogens drive the endoplasmic reticulum-associated degradation and promote proto-oncogene c-Myc expression in prostate cancer cells by androgen receptor/estrogen receptor signaling.
Erzurumlu Y, Dogan HK, Catakli D, Aydogdu E, Muhammed MT
Journal of cell communication and signaling 2023 Sep;17(3):793-811
Journal of cell communication and signaling 2023 Sep;17(3):793-811
Degradation of histone deacetylase 6 alleviates ROS-mediated apoptosis in renal ischemia-reperfusion injury.
Xia K, Qiu T, Jian Y, Liu H, Chen H, Liu X, Chen Z, Wang L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115128
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115128
METTL3-mediated N6-methyladenosine exacerbates ferroptosis via m6A-IGF2BP2-dependent mitochondrial metabolic reprogramming in sepsis-induced acute lung injury.
Zhang H, Wu D, Wang Y, Guo K, Spencer CB, Ortoga L, Qu M, Shi Y, Shao Y, Wang Z, Cata JP, Miao C
Clinical and translational medicine 2023 Sep;13(9):e1389
Clinical and translational medicine 2023 Sep;13(9):e1389
Triiodothyronine positively regulates endoplasmic reticulum-associated degradation (ERAD) and promotes androgenic signaling in androgen-dependent prostate cancer cells.
Erzurumlu Y, Muhammed MT
Cellular signalling 2023 Sep;109:110745
Cellular signalling 2023 Sep;109:110745
CD8 T Cell-Derived Exosomal miR-186-5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis.
Xu X, Qu S, Zhang C, Zhang M, Qin W, Ren G, Bao H, Li L, Zen K, Liu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(25):e2301492
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(25):e2301492
GART Functions as a Novel Methyltransferase in the RUVBL1/β-Catenin Signaling Pathway to Promote Tumor Stemness in Colorectal Cancer.
Tang C, Ke M, Yu X, Sun S, Luo X, Liu X, Zhou Y, Wang Z, Cui X, Gu C, Yang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(25):e2301264
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(25):e2301264
ECSIT Is a Critical Factor for Controlling Intestinal Homeostasis and Tumorigenesis through Regulating the Translation of YAP Protein.
Jiang Y, Ma C, Hu Y, Yang Y, Ma C, Wu C, Liu L, Wen S, Moynagh PN, Wang B, Yang S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(25):e2205180
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(25):e2205180
FBL promotes cancer cell resistance to DNA damage and BRCA1 transcription via YBX1.
Sun X, Gao C, Xu X, Li M, Zhao X, Wang Y, Wang Y, Zhang S, Yan Z, Liu X, Wu C
EMBO reports 2023 Sep 6;24(9):e56230
EMBO reports 2023 Sep 6;24(9):e56230
LINC00460 promotes angiogenesis by enhancing NF-κB-mediated VEGFA expression in cervical cancer cells.
Li F, Zhu W
Biochemical and biophysical research communications 2023 Sep 3;671:146-152
Biochemical and biophysical research communications 2023 Sep 3;671:146-152
Antidiabetic Effect of Collagen Peptides from Harpadon nehereus Bones in Streptozotocin-Induced Diabetes Mice by Regulating Oxidative Stress and Glucose Metabolism.
Lin Q, Guo Y, Li J, He S, Chen Y, Jin H
Marine drugs 2023 Sep 29;21(10)
Marine drugs 2023 Sep 29;21(10)
Krüppel-like Factor 15 Suppresses Ferroptosis by Activating an NRF2/GPX4 Signal to Protect against Folic Acid-Induced Acute Kidney Injury.
Yang X, Dong S, Fan Y, Xia Y, Yang F, Chen Z, Chen D, Zhang M, Liang D, Zeng C
International journal of molecular sciences 2023 Sep 26;24(19)
International journal of molecular sciences 2023 Sep 26;24(19)
CXXC finger protein 1 (CFP1) bridges the reshaping of genomic H3K4me3 signature to the advancement of lung adenocarcinoma.
Fan T, Xiao C, Liu H, Liu Y, Wang L, Tian H, Li C, He J
Signal transduction and targeted therapy 2023 Sep 21;8(1):369
Signal transduction and targeted therapy 2023 Sep 21;8(1):369
Ketogenic diet and β-Hydroxybutyrate alleviate ischemic brain injury in mice via an IRAKM-dependent pathway.
Lin C, Wang S, Xie J, Zhu J, Xu J, Liu K, Chen J, Yu M, Zhong H, Huang K, Pan S
European journal of pharmacology 2023 Sep 15;955:175933
European journal of pharmacology 2023 Sep 15;955:175933
An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption.
Zhang F, Zhang B, Wang Y, Jiang R, Liu J, Wei Y, Gao X, Zhu Y, Wang X, Sun M, Kang J, Liu Y, You G, Wei D, Xin J, Bao J, Wang M, Gu Y, Wang Z, Ye J, Guo S, Huang H, Sun Q
Nature 2023 Oct;622(7984):834-841
Nature 2023 Oct;622(7984):834-841
PAQR5 inhibits the growth and metastasis of clear cell renal cell carcinoma by suppressing the JAK/STAT3 signaling pathway.
Wang L, Yue Y, Zhang L, Jing M, Ma M, Liu C, Li Y, Xu S, Wang K, Wang X, Fan J, Zhang M
Cellular oncology (Dordrecht, Netherlands) 2023 Oct;46(5):1317-1332
Cellular oncology (Dordrecht, Netherlands) 2023 Oct;46(5):1317-1332
Dysregulation of iron homeostasis by TfR-1 renders EZH2 wild type diffuse large B-cell lymphoma resistance to EZH2 inhibition.
Yu L, Wang YF, Xiao J, Shen QQ, Chi SS, Gao YL, Lin DZ, Ding J, Fang YF, Chen Y
Acta pharmacologica Sinica 2023 Oct;44(10):2113-2124
Acta pharmacologica Sinica 2023 Oct;44(10):2113-2124
Cav3.2 T-Type calcium channels downregulation attenuates bone cancer pain induced by inhibiting IGF-1/HIF-1α signaling pathway in the rat spinal cord.
Liu Q, Lu Z, Ren H, Fu L, Wang Y, Bu H, Ma M, Ma L, Huang C, Wang J, Zang W, Cao J, Fan X
Journal of bone oncology 2023 Oct;42:100495
Journal of bone oncology 2023 Oct;42:100495
SEMA3B-AS1 suppresses colorectal carcinoma progression by inhibiting Semaphorin 3B-dependent VEGF signaling pathway activation.
Wang YQ, Chen H, Xu S, Liao CR, Xu A, Han Y, Yang MH, Zhao L, Hu SS, Wang L, Li QY, Zhan LY, Ding YQ, Wang S
MedComm 2023 Oct;4(5):e365
MedComm 2023 Oct;4(5):e365
Filamin A facilitates NLRP3 inflammasome activation during arsenic-induced nonalcoholic steatohepatitis.
Shi Y, Qiu T, Wu C, Yuan W, Yao X, Jiang L, Wang N, Wang L, Han Q, Yang G, Liu X, Sun X
Environmental science and pollution research international 2023 Oct;30(49):107703-107715
Environmental science and pollution research international 2023 Oct;30(49):107703-107715
3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis.
Mu M, Zhang Q, Zhao C, Li X, Chen Z, Sun X, Yu J
Cancer gene therapy 2023 Oct;30(10):1414-1425
Cancer gene therapy 2023 Oct;30(10):1414-1425
Multiple sevoflurane exposures during mid-trimester induce neurotoxicity in the developing brain initiated by 15LO2-Mediated ferroptosis.
Jiang Q, Wang C, Gao Q, Wu Z, Zhao P
CNS neuroscience & therapeutics 2023 Oct;29(10):2972-2985
CNS neuroscience & therapeutics 2023 Oct;29(10):2972-2985
SAFB associates with nascent RNAs and can promote gene expression in mouse embryonic stem cells.
Cherney RE, Eberhard QE, Giri G, Mills CA, Porrello A, Zhang Z, White D, Trotman JB, Herring LE, Dominguez D, Calabrese JM
RNA (New York, N.Y.) 2023 Oct;29(10):1535-1556
RNA (New York, N.Y.) 2023 Oct;29(10):1535-1556
Metformin Promotes Proliferation of Mouse Female Germline Stem Cells by Histone Acetylation Modification of Traf2.
Chen J, Wang L, Tian GG, Wang X, Li X, Wu J
Stem cell reviews and reports 2023 Oct;19(7):2329-2340
Stem cell reviews and reports 2023 Oct;19(7):2329-2340
The PRX-1/TLR4 axis promotes hypoxia-induced radiotherapy resistance in non-small cell lung cancer by targeting the NF-κB/p65 pathway.
Hao J, Song Z, Su J, Li L, Zou L, Zou K
Cellular signalling 2023 Oct;110:110806
Cellular signalling 2023 Oct;110:110806
NKRF in Cardiac Fibroblasts Protects against Cardiac Remodeling Post-Myocardial Infarction via Human Antigen R.
Guo C, Ji W, Yang W, Deng Q, Zheng T, Wang Z, Sui W, Zhai C, Yu F, Xi B, Yu X, Xu F, Zhang Q, Zhang W, Kong J, Zhang M, Zhang C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(30):e2303283
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(30):e2303283
LINC00922 decoys SIRT3 to facilitate the metastasis of colorectal cancer through up-regulation the H3K27 crotonylation of ETS1 promoter.
Liao M, Sun X, Zheng W, Wu M, Wang Y, Yao J, Ma Y, Gao S, Pei D
Molecular cancer 2023 Oct 4;22(1):163
Molecular cancer 2023 Oct 4;22(1):163
Identification of RECK as a protective prognostic indicator and a tumor suppressor through regulation of the ERK/MAPK signaling pathway in gastric cancer.
Qi F, Wang Y, Yu B, Li F
Journal of translational medicine 2023 Oct 30;21(1):766
Journal of translational medicine 2023 Oct 30;21(1):766
Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.
Wang M, Tang J, Zhang S, Pang K, Zhao Y, Liu N, Huang J, Kang J, Dong S, Li H, Tian Z, Duan B, Lu F, Zhang W
Cell death discovery 2023 Oct 24;9(1):394
Cell death discovery 2023 Oct 24;9(1):394
The ubiquitin E3 ligase MDM2 induces chemoresistance in colorectal cancer by degradation of ING3.
Zhang L, Zhu D, Jiang J, Min Z, Fa Z
Carcinogenesis 2023 Oct 20;44(7):562-575
Carcinogenesis 2023 Oct 20;44(7):562-575
A mitochondrial EglN1-AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress.
Jiang W, Zhang M, Gao C, Yan C, Gao R, He Z, Wei X, Xiong J, Ruan Z, Yang Q, Li J, Li Q, Zhong Z, Zhang M, Yuan Q, Hu H, Wang S, Hu MM, Cai C, Wu GS, Jiang C, Zhang YL, Zhang CS, Zhang J
The EMBO journal 2023 Oct 16;42(20):e113743
The EMBO journal 2023 Oct 16;42(20):e113743
Ginsenoside Rg5 promotes wound healing in diabetes by reducing the negative regulation of SLC7A11 on the efferocytosis of dendritic cells.
Xia W, Zhu Z, Xiang S, Yang Y
Journal of ginseng research 2023 Nov;47(6):784-794
Journal of ginseng research 2023 Nov;47(6):784-794
Targeting histone deacetylase suppresses tumor growth through eliciting METTL14-modified m(6) A RNA methylation in ocular melanoma.
Zhuang A, Gu X, Ge T, Wang S, Ge S, Chai P, Jia R, Fan X
Cancer communications (London, England) 2023 Nov;43(11):1185-1206
Cancer communications (London, England) 2023 Nov;43(11):1185-1206
SIRT6 mediated histone H3K9ac deacetylation involves myocardial remodelling through regulating myocardial energy metabolism in TAC mice.
Wu S, Zhang J, Peng C, Ma Y, Tian X
Journal of cellular and molecular medicine 2023 Nov;27(22):3451-3464
Journal of cellular and molecular medicine 2023 Nov;27(22):3451-3464
Knockdown of repulsive guidance molecule a promotes polarization of microglia into an anti-inflammatory phenotype after oxygen-glucose deprivation-reoxygenation in vitro.
Shen G, Xiao H, Huang S, Yuan X, Rongrong Z, Ma Y, Qin X
Neurochemistry international 2023 Nov;170:105546
Neurochemistry international 2023 Nov;170:105546
A Novel EYA1 Mutation Causing Alternative RNA Splicing in a Chinese Family With Branchio-Oto Syndrome: Implications for Molecular Diagnosis and Clinical Application.
Chen A, Ling J, Peng X, Liu X, Mao S, Chen Y, Qin M, Zhang S, Bai Y, Song J, Feng Z, Ma L, He D, Mei L, He C, Feng Y
Clinical and experimental otorhinolaryngology 2023 Nov;16(4):342-358
Clinical and experimental otorhinolaryngology 2023 Nov;16(4):342-358
A large-scale transcriptional analysis reveals herb-derived ginsenoside F2 suppressing hepatocellular carcinoma via inhibiting STAT3.
Tan X, Ma X, Dai Y, An J, Yu X, Li S, Liao Y, Pei T, Tang Y, Gui Y, Zhou S, Guo D, Deng Y, Hu K, Wang D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Nov;120:155031
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Nov;120:155031
KLF5/MDM2 Axis Modulates Oxidative Stress and Epithelial-Mesenchymal Transition in Human Lens Epithelial Cells: The Role in Diabetic Cataract.
Li X, Chen D, Ouyang B, Wang S, Li Y, Li L, Zhu S, Zheng G
Laboratory investigation; a journal of technical methods and pathology 2023 Nov;103(11):100226
Laboratory investigation; a journal of technical methods and pathology 2023 Nov;103(11):100226
Design, synthesis, and bioactivity evaluation of novel amide/sulfonamide derivatives as potential anti-inflammatory agents against acute lung injury and ulcerative colitis.
Chen P, Yang J, Zhou Y, Li X, Zou Y, Zheng Z, Guo M, Chen Z, Cho WJ, Chattipakorn N, Wu W, Tang Q, Liang G
European journal of medicinal chemistry 2023 Nov 5;259:115706
European journal of medicinal chemistry 2023 Nov 5;259:115706
Covalent Peptide LSD1 Inhibitor Specifically Recognizes Cys360 in the Enzyme-Active Region.
Luo Q, Ma Y, Liang H, Feng Y, Liu N, Lian C, Zhu L, Ye Y, Liu Z, Hou Z, Chen S, Wang Y, Dai C, Song C, Zhang M, He Z, Xing Y, Zhong W, Li S, Wu J, Lu F, Yin F, Li Z
Journal of medicinal chemistry 2023 Nov 23;66(22):15409-15423
Journal of medicinal chemistry 2023 Nov 23;66(22):15409-15423
Small molecule activates citrullination through targeting PAD2.
Zhang X, Shen M, Zhu H, Zhang J, Yang M, Su K, Zhang Y, Fu W, Ke X, Qu Y
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2023 Nov 20;378(1890):20220248
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2023 Nov 20;378(1890):20220248
Inhibiting MEK1 R189 citrullination enhances the chemosensitivity of docetaxel to multiple tumour cells.
Xue T, Fei S, Gu J, Li N, Zhang P, Liu X, Thompson PR, Zhang X
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2023 Nov 20;378(1890):20220246
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2023 Nov 20;378(1890):20220246
Cinnamaldehyde Alleviates Bone Loss by Targeting Oxidative Stress and Mitochondrial Damage via the Nrf2/HO-1 Pathway in BMSCs and Ovariectomized Mice.
Lin BH, Ma RX, Wu JT, Du SQ, Lv YY, Yu HN, Zhang W, Mao SM, Liu GY, Bu YT, Chen ZH, Jin C, Wu ZY, Yang L
Journal of agricultural and food chemistry 2023 Nov 2;
Journal of agricultural and food chemistry 2023 Nov 2;
Regulation of the Hippo/YAP axis by CXCR7 in the tumorigenesis of gastric cancer.
Wang T, Wang D, Sun Y, Zhuang T, Li X, Yang H, Zang Y, Liu Z, Yang P, Zhang C, Cui J, Fu M, Zhang S, Su P, Li Z, Zhu J, Ding Y
Journal of experimental & clinical cancer research : CR 2023 Nov 10;42(1):297
Journal of experimental & clinical cancer research : CR 2023 Nov 10;42(1):297
MAGL inhibition relieves synovial inflammation and pain via regulating NOX4-Nrf2 redox balance in osteoarthritis.
Li X, Tao H, Zhou J, Zhang L, Shi Y, Zhang C, Sun W, Chu M, Chen K, Gu C, Yang X, Geng D, Hao Y
Free radical biology & medicine 2023 Nov 1;208:13-25
Free radical biology & medicine 2023 Nov 1;208:13-25
Silencing of adipocyte enhancer-binding protein 1 (AEBP1) alleviates renal fibrosis in vivo and in vitro via inhibition of the β-catenin signaling pathway.
Liu N, Liu D, Cao S, Lei J
Human cell 2023 May;36(3):972-986
Human cell 2023 May;36(3):972-986
Novel insights into the angiogenic function of JMJD2B in diabetic hind limb ischemia: involvement of activating Wnt/β-catenin pathway.
Wang Z, Li M, Liu Y, Qiao Z, Zu X, Cao T, Bai T
Human cell 2023 May;36(3):1011-1023
Human cell 2023 May;36(3):1011-1023
Lycopene inhibits endothelial-to-mesenchymal transition of choroidal vascular endothelial cells in laser-induced mouse choroidal neovascularization.
Li L, Cao X, Huang L, Huang X, Gu J, Yu X, Zhu Y, Zhou Y, Song Y, Zhu M
Journal of cellular and molecular medicine 2023 May;27(10):1327-1340
Journal of cellular and molecular medicine 2023 May;27(10):1327-1340
N6-Methyladenosine-Mediated Up-Regulation of FZD10 Regulates Liver Cancer Stem Cells' Properties and Lenvatinib Resistance Through WNT/β-Catenin and Hippo Signaling Pathways.
Wang J, Yu H, Dong W, Zhang C, Hu M, Ma W, Jiang X, Li H, Yang P, Xiang D
Gastroenterology 2023 May;164(6):990-1005
Gastroenterology 2023 May;164(6):990-1005
NSD3, a member of nuclear receptor-binding SET domain family, is a potential prognostic biomarker for pancreatic cancer.
Xiong Q, Zhou Y, Zhang S, Zhang Y, Xu Y, Yang Y, Zhou C, Zeng Z, Han J, Zhu Q
Cancer medicine 2023 May;12(9):10961-10978
Cancer medicine 2023 May;12(9):10961-10978
PcEiger links the Imd/Relish pathway to ROS production in the intestine of the red swamp crayfish.
Wang H, Liu PP, Wei Z, Wang XW
EMBO reports 2023 May 4;24(5):e55903
EMBO reports 2023 May 4;24(5):e55903
Anti-Neuroinflammatory Meroterpenoids from a Chinese Collection of the Brown Alga Sargassum siliquastrum.
Qi Y, Wang Z, Zhang J, Tang S, Zhu H, Jiang B, Li X, Wang J, Sun Z, Zhao M, Zhu H, Yan P
Journal of natural products 2023 May 26;86(5):1284-1293
Journal of natural products 2023 May 26;86(5):1284-1293
Metformin promotes female germline stem cell proliferation by upregulating Gata-binding protein 2 with histone β-hydroxybutyrylation.
Wang X, Tian GG, Cheng W, Yu X, Li X, Wu J
Stem cell research & therapy 2023 May 26;14(1):144
Stem cell research & therapy 2023 May 26;14(1):144
Wei-Tong-Xin ameliorated cisplatin-induced mitophagy and apoptosis in gastric antral mucosa by activating the Nrf2/HO-1 pathway.
Zhang X, Wang S, Jin Y, Wang J, Wang R, Yang X, Zhang S, Yan T, Jia Y
Journal of ethnopharmacology 2023 May 23;308:116253
Journal of ethnopharmacology 2023 May 23;308:116253
Hepatocyte ferroptosis contributes to anti-tuberculosis drug-induced liver injury: Involvement of the HIF-1α/SLC7A11/GPx4 axis.
Liu Y, Chen W, Cen Y, Zhao X, Chen Z, Liang Y, Huang Z, He X, Yang G
Chemico-biological interactions 2023 May 1;376:110439
Chemico-biological interactions 2023 May 1;376:110439
Eosinophils protect against pulmonary hypertension through 14-HDHA and 17-HDHA.
Shu T, Zhang J, Zhou Y, Chen Z, Li J, Tang Q, Lei W, Xing Y, Wang J, Wang C
The European respiratory journal 2023 Mar;61(3)
The European respiratory journal 2023 Mar;61(3)
A Physiologically Responsive Nanocomposite Hydrogel for Treatment of Head and Neck Squamous Cell Carcinoma via Proteolysis-Targeting Chimeras Enhanced Immunotherapy.
Wu Y, Chang X, Yang G, Chen L, Wu Q, Gao J, Tian R, Mu W, Gooding JJ, Chen X, Sun S
Advanced materials (Deerfield Beach, Fla.) 2023 Mar;35(12):e2210787
Advanced materials (Deerfield Beach, Fla.) 2023 Mar;35(12):e2210787
Abamectin causes cardiac dysfunction in carp via inhibiting redox equilibrium and resulting in immune inflammatory response and programmed cell death.
Zhao P, Wang Y, Yang Q, Yu G, Ma F, Dong J
Environmental science and pollution research international 2023 Mar;30(11):29494-29509
Environmental science and pollution research international 2023 Mar;30(11):29494-29509
Neuroprotective effect of a Keap1-Nrf2 Protein-Protein Inter-action inhibitor on cerebral Ischemia/Reperfusion injury.
Qi Z, Tong Y, Luo H, Chen M, Zhou N, Chen L
Bioorganic chemistry 2023 Mar;132:106350
Bioorganic chemistry 2023 Mar;132:106350
1,25(OH)(2) D(3) induced vitamin D receptor signaling negatively regulates endoplasmic reticulum-associated degradation (ERAD) and androgen receptor signaling in human prostate cancer cells.
Erzurumlu Y, Aydogdu E, Dogan HK, Catakli D, Muhammed MT, Buyuksandic B
Cellular signalling 2023 Mar;103:110577
Cellular signalling 2023 Mar;103:110577
PABPN1 regulates mRNA alternative polyadenylation to inhibit bladder cancer progression.
Chen L, Dong W, Zhou M, Yang C, Xiong M, Kazobinka G, Chen Z, Xing Y, Hou T
Cell & bioscience 2023 Mar 6;13(1):45
Cell & bioscience 2023 Mar 6;13(1):45
9-Butyl-Harmol Exerts Antiviral Activity against Newcastle Disease Virus through Targeting GSK-3β and HSP90β.
Wang C, Wang T, Hu R, Duan L, Hou Q, Han Y, Dai J, Wang W, Ren S, Liu H, Wang X, Xiao S, Li N, Wang J, Yang Z
Journal of virology 2023 Mar 30;97(3):e0198422
Journal of virology 2023 Mar 30;97(3):e0198422
Nuclear PD-L1 promotes EGR1-mediated angiogenesis and accelerates tumorigenesis.
Yu J, Zhuang A, Gu X, Hua Y, Yang L, Ge S, Ruan J, Chai P, Jia R, Fan X
Cell discovery 2023 Mar 28;9(1):33
Cell discovery 2023 Mar 28;9(1):33
Baicalin facilitates remyelination and suppresses neuroinflammation in rats with chronic cerebral hypoperfusion by activating Wnt/β-catenin and inhibiting NF-κB signaling.
Xiao Y, Guan T, Yang X, Xu J, Zhang J, Qi Q, Teng Z, Dong Y, Gao Y, Li M, Meng N, Lv P
Behavioural brain research 2023 Mar 28;442:114301
Behavioural brain research 2023 Mar 28;442:114301
Evolutionarily distinct and sperm-specific supersized chromatin loops are marked by Helitron transposons in Xenopus tropicalis.
Shi Z, Xu J, Niu L, Shen W, Yan S, Tan Y, Quan X, Cheung E, Huang K, Chen Y, Li L, Hou C
Cell reports 2023 Mar 28;42(3):112151
Cell reports 2023 Mar 28;42(3):112151
Selective Targeting of Class I HDAC Reduces Microglial Inflammation in the Entorhinal Cortex of Young APP/PS1 Mice.
Wang C, Shen D, Hu Y, Chen J, Liu J, Huang Y, Yu X, Chu H, Zhang C, Yin L, Liu Y, Ma H
International journal of molecular sciences 2023 Mar 2;24(5)
International journal of molecular sciences 2023 Mar 2;24(5)
LNX2 involves in the role of ghrelin to promote the neuronal differentiation of adipose tissue-derived mesenchymal stem cells.
Liu GB, Zhan T, Pan YM, Zhang DW, Zheng HZ, Xu B, Li TT, Dong CL, Cheng YX
Journal of bioenergetics and biomembranes 2023 Jun;55(3):195-205
Journal of bioenergetics and biomembranes 2023 Jun;55(3):195-205
Atorvastatin prevents endoplasmic reticulum stress-mediated apoptosis via the Nrf2/HO-1 signaling pathway in TBI mice.
Feng Y, Lang J, Sun B, Yan Z, Zhao Z, Sun G
Neurological research 2023 Jun;45(6):590-602
Neurological research 2023 Jun;45(6):590-602
Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells.
Li ZB, Jiang L, Ni JD, Xu YH, Liu F, Liu WM, Wang SG, Liu ZQ, Wang CY
Acta pharmacologica Sinica 2023 Jun;44(6):1191-1205
Acta pharmacologica Sinica 2023 Jun;44(6):1191-1205
Targeting HMGA1 contributes to immunotherapy in aggressive breast cancer while suppressing EMT.
Chang X, Liu J, Yang Q, Gao Y, Ding X, Zhao J, Li Y, Liu Z, Li Z, Wu Y, Zuo D
Biochemical pharmacology 2023 Jun;212:115582
Biochemical pharmacology 2023 Jun;212:115582
Nuciferine improves random skin flap survival via TFEB-mediated activation of autophagy-lysosomal pathway.
Xue K, Zhang G, Zhou Y, Wang K, Yao Z, Chen J, Zhang Y, Li Z, Li Z, Zheng Z, Feng Y, Mao C, Lin C, Xia W
International immunopharmacology 2023 Jun;119:110204
International immunopharmacology 2023 Jun;119:110204
Syk-dependent alternative homologous recombination activation promotes cancer resistance to DNA targeted therapy.
Zhou Q, Tu X, Hou X, Yu J, Zhao F, Huang J, Kloeber J, Olson A, Gao M, Luo K, Zhu S, Wu Z, Zhang Y, Sun C, Zeng X, Schoolmeester K, Weroha J, Wang L, Mutter R, Lou Z
Research square 2023 Jun 9;
Research square 2023 Jun 9;
Discovery of a New-Generation S-Adenosylmethionine-Noncompetitive Covalent Inhibitor Targeting the Lysine Methyltransferase Enhancer of Zeste Homologue 2.
Zhang Y, Yang H, Li B, Li J, Li H, Shi Q, Li B, Wang Z, Zheng J, Zhang Y, Dong H, Huang X, Wang Y
Journal of medicinal chemistry 2023 Jun 8;66(11):7629-7644
Journal of medicinal chemistry 2023 Jun 8;66(11):7629-7644
TRIM5α recruits HDAC1 to p50 and Sp1 and promotes H3K9 deacetylation at the HIV-1 LTR.
Ran XH, Zhu JW, Ni RZ, Zheng YT, Chen YY, Zheng WH, Mu D
Nature communications 2023 Jun 8;14(1):3343
Nature communications 2023 Jun 8;14(1):3343
Identification of the E2F1-RAD51AP1 axis as a key factor in MGMT-methylated GBM TMZ resistance.
Zhou J, Tong F, Zhao J, Cui X, Wang Y, Wang G, Kang C, Liu X, Wang Q
Cancer biology & medicine 2023 Jun 5;20(5):385-400
Cancer biology & medicine 2023 Jun 5;20(5):385-400
20-hydroxyecdysone reprograms amino acid metabolism to support the metamorphic development of Helicoverpa armigera.
Wang XP, Sun SP, Li YX, Wang L, Dong DJ, Wang JX, Zhao XF
Cell reports 2023 Jun 27;42(6):112644
Cell reports 2023 Jun 27;42(6):112644
Organization, genomic targeting, and assembly of three distinct SWI/SNF chromatin remodeling complexes in Arabidopsis.
Fu W, Yu Y, Shu J, Yu Z, Zhong Y, Zhu T, Zhang Z, Liang Z, Cui Y, Chen C, Li C
The Plant cell 2023 Jun 26;35(7):2464-2483
The Plant cell 2023 Jun 26;35(7):2464-2483
Structural basis of the interaction between BCL9-Pygo and LDB-SSBP complexes in assembling the Wnt enhanceosome.
Wang H, Bienz M, Yan XX, Xu W
Nature communications 2023 Jun 22;14(1):3702
Nature communications 2023 Jun 22;14(1):3702
SMYD2 inhibition-mediated hypomethylation of Ku70 contributes to impaired nonhomologous end joining repair and antitumor immunity.
Tang M, Chen G, Tu B, Hu Z, Huang Y, DuFort CC, Wan X, Mao Z, Liu Y, Zhu WG, Lu W
Science advances 2023 Jun 16;9(24):eade6624
Science advances 2023 Jun 16;9(24):eade6624
Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis.
Guo T, Hu S, Xu W, Zhou J, Chen F, Gao T, Qu W, Chen F, Lv Z, Lu L
iScience 2023 Jun 16;26(6):106882
iScience 2023 Jun 16;26(6):106882
Kinsenoside alleviates oxidative stress-induced blood-brain barrier dysfunction via promoting Nrf2/HO-1 pathway in ischemic stroke.
Qiao N, An Z, Fu Z, Chen X, Tong Q, Zhang Y, Ren H
European journal of pharmacology 2023 Jun 15;949:175717
European journal of pharmacology 2023 Jun 15;949:175717
Fibroblast growth factor 21 (FGF21) attenuates tacrolimus-induced hepatic lipid accumulation through transcription factor EB (TFEB)-regulated lipophagy.
Zhang Z, Xu L, Qiu X, Yang X, Lian Z, Wei X, Lu D, Xu X
Journal of Zhejiang University. Science. B 2023 Jun 15;24(6):485-495
Journal of Zhejiang University. Science. B 2023 Jun 15;24(6):485-495
Epstein-Barr Virus Envelope Glycoprotein gp110 Inhibits IKKi-Mediated Activation of NF-κB and Promotes the Degradation of β-Catenin.
Guo Y, Pan L, Wang L, Wang S, Fu J, Luo W, Wang K, Li X, Huang C, Liu Y, Kang H, Zeng Q, Fu X, Huang Z, Li W, He Y, Li L, Peng T, Yang H, Li M, Xiao B, Cai M
Microbiology spectrum 2023 Jun 15;11(3):e0032623
Microbiology spectrum 2023 Jun 15;11(3):e0032623
Inhibiting HIF-1 signaling alleviates HTRA1-induced RPE senescence in retinal degeneration.
Xu W, Liu X, Han W, Wu K, Zhao M, Mei T, Shang B, Wu J, Luo J, Lai Y, Yang B, Zhuo Y, Lu L, Liu Y, Tian XL, Zhao L
Cell communication and signaling : CCS 2023 Jun 14;21(1):134
Cell communication and signaling : CCS 2023 Jun 14;21(1):134
Karyopherin Subunit Alpha 1 Enhances the Malignant Behaviors of Colon Cancer Cells via Promoting Nuclear Factor-κB p65 Nuclear Translocation.
Zhao L, Wu D, Qu Q, Li Z, Yin H
Digestive diseases and sciences 2023 Jul;68(7):3018-3031
Digestive diseases and sciences 2023 Jul;68(7):3018-3031
Mangiferin Protects DNase 2 Abundance via Nrf2 Activation to Prevent Cytosolic mtDNA Accumulation during Liver Injury.
Li L, Zhen Y, Chen X, Cao L, Song J, Liu X, Wang M
Molecular nutrition & food research 2023 Jul;67(14):e2200885
Molecular nutrition & food research 2023 Jul;67(14):e2200885
Direct Knockdown of PDZ and LIM Domain 1 Using an Adenoviral Delivery System Accelerates Osteogenesis and Fracture Healing in Mice.
Chen Z, Zhao Q, Zhang R, Chen L, Gao S, Wang Y, Li T, Xue J
Human gene therapy 2023 Jul;34(13-14):649-661
Human gene therapy 2023 Jul;34(13-14):649-661
Radiation resistance of cancer cells caused by mitochondrial dysfunction depends on SIRT3-mediated mitophagy.
Wei Y, Xiao G, Xu H, Sun X, Shi Y, Wang F, Kang J, Peng J, Zhou F
The FEBS journal 2023 Jul;290(14):3629-3645
The FEBS journal 2023 Jul;290(14):3629-3645
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity.
Lei Y, VanPortfliet JJ, Chen YF, Bryant JD, Li Y, Fails D, Torres-Odio S, Ragan KB, Deng J, Mohan A, Wang B, Brahms ON, Yates SD, Spencer M, Tong CW, Bosenberg MW, West LC, Shadel GS, Shutt TE, Upton JW, Li P, West AP
Cell 2023 Jul 6;186(14):3013-3032.e22
Cell 2023 Jul 6;186(14):3013-3032.e22
Dark repair of sunlight-inactivated tetracycline-resistant bacteria: Mechanisms and important role of bacteria in viable but non-culturable state.
Zhang T, Cheng F, Chen X, Zhang YN, Qu J, Chen J, Peijnenburg WJGM
Journal of hazardous materials 2023 Jul 15;454:131560
Journal of hazardous materials 2023 Jul 15;454:131560
The inhibition of FKBP5 protects β-cell survival under inflammation stress via AKT/FOXO1 signaling.
Liu N, Li R, Cao J, Song X, Ma W, Liu T, Wang L, Zou J, Zhang B, Liu Z, Liang R, Zheng R, Wang S
Cell death discovery 2023 Jul 14;9(1):247
Cell death discovery 2023 Jul 14;9(1):247
The Novel Role of Zfp296 in Mammalian Embryonic Genome Activation as an H3K9me3 Modulator.
Gao L, Zhang Z, Zheng X, Wang F, Deng Y, Zhang Q, Wang G, Zhang Y, Liu X
International journal of molecular sciences 2023 Jul 12;24(14)
International journal of molecular sciences 2023 Jul 12;24(14)
USP15 promotes pulmonary vascular remodeling in pulmonary hypertension in a YAP1/TAZ-dependent manner.
Wu Z, Zhu L, Nie X, Wei L, Qi Y
Experimental & molecular medicine 2023 Jan;55(1):183-195
Experimental & molecular medicine 2023 Jan;55(1):183-195
The novel sustained 3-hydroxybutyrate donor poly-D-3-hydroxybutyric acid prevents inflammatory bowel disease through upregulation of regulatory T-cells.
Suzuki R, Mishima M, Nagane M, Mizugaki H, Suzuki T, Komuro M, Shimizu T, Fukuyama T, Takeda S, Ogata M, Miyamoto T, Aihara N, Kamiie J, Kamisuki S, Yokaryo H, Yamashita T, Satoh T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Jan;37(1):e22708
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Jan;37(1):e22708
Halofuginone ameliorates systemic lupus erythematosus by targeting Blk in myeloid-derived suppressor cells.
Ni J, Li X, Tu X, Zhu H, Wang S, Hou Y, Dou H
International immunopharmacology 2023 Jan;114:109487
International immunopharmacology 2023 Jan;114:109487
Yishen-Qingli-Huoxue formula attenuates renal fibrosis by inhibiting indoxyl sulfate via AhR/snai1 signaling.
Chen C, Sun S, Zhao J, Wu Q, He W, Sun W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154546
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154546
Zhen Wu decoction represses renal fibrosis by invigorating tubular NRF2 and TFAM to fuel mitochondrial bioenergetics.
Zheng M, Hu Z, Wang Y, Wang C, Zhong C, Cui W, You J, Gao B, Sun X, La L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154495
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154495
DOT1L Epigenetically Regulates Autophagy and Mitochondria Fusion in Cell Lines of Renal Cancer.
Hou Y, Liu J, Huang S, Wang L, Hu J, Liu X
Technology in cancer research & treatment 2023 Jan-Dec;22:15330338231167249
Technology in cancer research & treatment 2023 Jan-Dec;22:15330338231167249
A Novel in Duck Myoblasts: The Transcription Factor Retinoid X Receptor Alpha (RXRA) Inhibits Lipid Accumulation by Promoting CD36 Expression.
Pan Z, Chen X, Wu D, Li X, Gao W, Li G, Du G, Zhang C, Jin S, Geng Z
International journal of molecular sciences 2023 Jan 7;24(2)
International journal of molecular sciences 2023 Jan 7;24(2)
Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression.
Hu Z, Wei F, Su Y, Wang Y, Shen Y, Fang Y, Ding J, Chen Y
Signal transduction and targeted therapy 2023 Jan 6;8(1):11
Signal transduction and targeted therapy 2023 Jan 6;8(1):11
ER stress-enhanced HMGA2 plays an important role in Cr (VI)-induced glycolysis and inhibited oxidative phosphorylation by targeting the transcription of ATF4.
Luo S, Zhang C, Gao Z, Jiang L, Li Q, Shi X, Kong Y, Cao J
Chemico-biological interactions 2023 Jan 5;369:110293
Chemico-biological interactions 2023 Jan 5;369:110293
SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.
Cheng L, He Q, Liu B, Chen L, Lv F, Li X, Li Y, Liu C, Song Y, Xing Y
Cell death & disease 2023 Jan 31;14(1):74
Cell death & disease 2023 Jan 31;14(1):74
Low-Dose Sodium Salicylate Promotes Ovulation by Regulating Steroids via CYP17A1.
Li T, Ren X, Li T, Yu L, Teng M, Zheng Y, Lei A
International journal of molecular sciences 2023 Jan 30;24(3)
International journal of molecular sciences 2023 Jan 30;24(3)
FTO-dependent m(6)A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.
Li B, Xi W, Bai Y, Liu X, Zhang Y, Li L, Bian L, Liu C, Tang Y, Shen L, Yang L, Gu X, Xie J, Zhou Z, Wang Y, Yu X, Wang J, Chao J, Han B, Yao H
Nature communications 2023 Jan 30;14(1):489
Nature communications 2023 Jan 30;14(1):489
Discovery of IHMT-337 as a potent irreversible EZH2 inhibitor targeting CDK4 transcription for malignancies.
Mei H, Wu H, Yang J, Zhou B, Wang A, Hu C, Qi S, Jiang Z, Zou F, Wang B, Liu F, Chen Y, Wang W, Liu J, Liu Q
Signal transduction and targeted therapy 2023 Jan 16;8(1):18
Signal transduction and targeted therapy 2023 Jan 16;8(1):18
Embryonic 6:2 FTOH exposure causes reproductive toxicity by disrupting the formation of the blood-testis barrier in offspring mice.
Xia Y, Hao L, Li Y, Li Y, Chen J, Li L, Han X, Liu Y, Wang X, Li D
Ecotoxicology and environmental safety 2023 Jan 15;250:114497
Ecotoxicology and environmental safety 2023 Jan 15;250:114497
Glioma-derived LRIG3 interacts with NETO2 in tumor-associated macrophages to modulate microenvironment and suppress tumor growth.
Li Y, Wang W, Hou X, Huang W, Zhang P, He Y, Wang B, Duan Q, Mao F, Guo D
Cell death & disease 2023 Jan 13;14(1):28
Cell death & disease 2023 Jan 13;14(1):28
FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.
Xi H, Hu Z, Han S, Liu X, Wang L, Hu J
Theriogenology 2023 Jan 1;195:103-114
Theriogenology 2023 Jan 1;195:103-114
Novel lncRNA-prader willi/angelman region RNA, SNRPN neighbour (PWARSN) aggravates tubular epithelial cell pyroptosis by regulating TXNIP via dual way in diabetic kidney disease.
Song Y, Guo F, Zhao YY, Ma XJ, Wu LN, Yu JF, Ji HF, Shao MW, Huang FJ, Zhao L, Fan XJ, Xu YN, Wang QZ, Qin GJ
Cell proliferation 2023 Feb;56(2):e13349
Cell proliferation 2023 Feb;56(2):e13349
Progesterone regulates the endoplasmic reticulum-associated degradation and Unfolded Protein Response axis by mimicking the androgenic stimulation in prostate cancer cells.
Erzurumlu Y, Dogan HK, Catakli D
Molecular biology reports 2023 Feb;50(2):1253-1265
Molecular biology reports 2023 Feb;50(2):1253-1265
Catalpol Ameliorates Oxidative Stress and Neuroinflammation after Traumatic Brain Injury in Rats.
Ni H, Rui Q, Kan X, Gao R, Zhang L, Zhang B
Neurochemical research 2023 Feb;48(2):681-695
Neurochemical research 2023 Feb;48(2):681-695
TRIM24 is critical for the cellular response to DNA double-strand breaks through regulating the recruitment of MRN complex.
Wang Y, Yao Y, Wei Q, Long S, Chen Y, Xie J, Tan R, Jiang W, Zhang Q, Wu D, Xiao S, Wan F, Fu K
Oncogene 2023 Feb;42(8):586-600
Oncogene 2023 Feb;42(8):586-600
SPON2 promotes the bone metastasis of lung adenocarcinoma via activation of the NF-κB signaling pathway.
Wu M, Kong D, Zhang Y
Bone 2023 Feb;167:116630
Bone 2023 Feb;167:116630
NF-κB p65 and SETDB1 expedite lipopolysaccharide-induced intestinal inflammation in mice by inducing IRF7/NLR-dependent macrophage M1 polarization.
Chen L, Dai M, Zuo W, Dai Y, Yang Q, Yu S, Huang M, Liu H
International immunopharmacology 2023 Feb;115:109554
International immunopharmacology 2023 Feb;115:109554
Isothiocyanates attenuate immune checkpoint blockage therapy in gastric cancer via induction of PD-L1 expression.
Zhang Q, Cao W, Yang C, Hong L, Geng S, Han H, Zhong C
The Journal of nutritional biochemistry 2023 Feb;112:109226
The Journal of nutritional biochemistry 2023 Feb;112:109226
LIM and Cysteine-Rich Domains 1 Promotes Transforming Growth Factor β1-Induced Epithelial-Mesenchymal Transition in Human Kidney 2 Cells.
Yu R, Wu Y, He P, Bai Y, Zhang Y, Bian X, Sun G, Zhang B
Laboratory investigation; a journal of technical methods and pathology 2023 Feb;103(2):100016
Laboratory investigation; a journal of technical methods and pathology 2023 Feb;103(2):100016
Non-Esterified Fatty Acid-Induced Apoptosis in Bovine Granulosa Cells via ROS-Activated PI3K/AKT/FoxO1 Pathway.
Lei Z, Ali I, Yang M, Yang C, Li Y, Li L
Antioxidants (Basel, Switzerland) 2023 Feb 9;12(2)
Antioxidants (Basel, Switzerland) 2023 Feb 9;12(2)
Aryl hydrocarbon receptor dependent anti-inflammation and neuroprotective effects of tryptophan metabolites on retinal ischemia/reperfusion injury.
Yang Y, Wang N, Xu L, Liu Y, Huang L, Gu M, Wu Y, Guo W, Sun H
Cell death & disease 2023 Feb 8;14(2):92
Cell death & disease 2023 Feb 8;14(2):92
Multi-Omics Approaches for Revealing the Epigenetic Regulation of Histone H3.1 during Spermatogonial Stem Cell Differentiation In Vitro.
Liu L, Li H, Wang M, Zhang X, Ren J, Yuan Y, Sha J, Guo X
International journal of molecular sciences 2023 Feb 7;24(4)
International journal of molecular sciences 2023 Feb 7;24(4)
Upregulated GPRC5A disrupting the Hippo pathway promotes the proliferation and migration of pancreatic cancer cells via the cAMP-CREB axis.
Fang W, Yu X, Deng J, Yu B, Xiong J, Ma M
Discover oncology 2023 Feb 3;14(1):17
Discover oncology 2023 Feb 3;14(1):17
TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
Zheng W, Zhou Z, Rui Y, Ye R, Xia F, Guo F, Liu X, Su J, Lou M, Yu XF
Signal transduction and targeted therapy 2023 Feb 24;8(1):79
Signal transduction and targeted therapy 2023 Feb 24;8(1):79
Atf7ip Inhibits Osteoblast Differentiation via Negative Regulation of the Sp7 Transcription Factor.
Hu G, Shi X, Qu X, Han C, Hu A, Jia Z, Yang J, Liu H, Wu Y
International journal of molecular sciences 2023 Feb 21;24(5)
International journal of molecular sciences 2023 Feb 21;24(5)
PSAT1 positively regulates the osteogenic lineage differentiation of periodontal ligament stem cells through the ATF4/PSAT1/Akt/GSK3β/β-catenin axis.
Jia L, Li D, Wang YN, Zhang D, Xu X
Journal of translational medicine 2023 Feb 2;21(1):70
Journal of translational medicine 2023 Feb 2;21(1):70
Exendin-4 alleviates myocardial ischemia reperfusion injury by enhancing autophagy through promoting nuclear translocation of TFEB.
He W, Tong G, Fan H, Zhen C, Zeng L, Xue L, Chen J, Sun Z, He P
Experimental cell research 2023 Feb 15;423(2):113469
Experimental cell research 2023 Feb 15;423(2):113469
2-Undecanone alleviates asthma by inhibiting NF-κB pathway.
Song G, Yu S, Zhang Y, Sun M, Zhang B, Peng M
Biochemistry and cell biology = Biochimie et biologie cellulaire 2023 Feb 1;101(1):101-111
Biochemistry and cell biology = Biochimie et biologie cellulaire 2023 Feb 1;101(1):101-111
Dimethyl fumarate ameliorates erectile dysfunction in bilateral cavernous nerve injury rats by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis of nerve via activation of Nrf2/HO-1 signaling pathway.
Song G, Wang J, Liu J, Ruan Y
Redox biology 2023 Dec;68:102938
Redox biology 2023 Dec;68:102938
BDH1-mediated LRRC31 regulation dependent on histone lysine β-hydroxybutyrylation to promote lung adenocarcinoma progression.
Huang J, Liang L, Jiang S, Liu Y, He H, Sun X, Li Y, Xie L, Tao Y, Cong L, Jiang Y
MedComm 2023 Dec;4(6):e449
MedComm 2023 Dec;4(6):e449
Curcumin Alleviates Hepatic Ischemia-Reperfusion Injury by Inhibiting Neutrophil Extracellular Traps Formation.
Zhu C, Shi S, Jiang P, Huang X, Zhao J, Jin Y, Shen Y, Zhou X, Liu H, Cai J
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2023 Dec;36(1):2164813
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2023 Dec;36(1):2164813
HIF-1α promotes astrocytic production of macrophage migration inhibitory factor following spinal cord injury.
Hao H, Hou Y, Li A, Niu L, Li S, He B, Zhang X, Song H, Cai R, Zhou Y, Yao C, Wang Y, Wang Y
CNS neuroscience & therapeutics 2023 Dec;29(12):3802-3814
CNS neuroscience & therapeutics 2023 Dec;29(12):3802-3814
Brusatol enhances MEF2A expression to inhibit RCC progression through the Wnt signalling pathway in renal cell carcinoma.
Wang T, Zhou Y, Bao H, Liu B, Wang M, Wang L, Pan T
Journal of cellular and molecular medicine 2023 Dec;27(23):3897-3910
Journal of cellular and molecular medicine 2023 Dec;27(23):3897-3910
Delineating the early dissemination mechanisms of acral melanoma by integrating single-cell and spatial transcriptomic analyses.
Wei C, Sun W, Shen K, Zhong J, Liu W, Gao Z, Xu Y, Wang L, Hu T, Ren M, Li Y, Zhu Y, Zheng S, Zhu M, Luo R, Yang Y, Hou Y, Qi F, Zhou Y, Chen Y, Gu J
Nature communications 2023 Dec 8;14(1):8119
Nature communications 2023 Dec 8;14(1):8119
The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells.
Claude-Taupin A, Isnard P, Bagattin A, Kuperwasser N, Roccio F, Ruscica B, Goudin N, Garfa-Traoré M, Regnier A, Turinsky L, Burtin M, Foretz M, Pontoglio M, Morel E, Viollet B, Terzi F, Codogno P, Dupont N
Nature communications 2023 Dec 5;14(1):8056
Nature communications 2023 Dec 5;14(1):8056
E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC.
Tang F, Lu C, He X, Lin W, Xie B, Gao X, Peng Y, Yang D, Sun L, Weng L
Cell reports 2023 Dec 26;42(12):113477
Cell reports 2023 Dec 26;42(12):113477
H2O2-dependent oxidation of the transcription factor GmNTL1 promotes salt tolerance in soybean.
Zhang W, Zhi W, Qiao H, Huang J, Li S, Lu Q, Wang N, Li Q, Zhou Q, Sun J, Bai Y, Zheng X, Bai M, Van Breusegem F, Xiang F
The Plant cell 2023 Dec 21;36(1):112-135
The Plant cell 2023 Dec 21;36(1):112-135
m(6)A methylation-mediated PGC-1α contributes to ferroptosis via regulating GSTK1 in arsenic-induced hepatic insulin resistance.
Zhang J, Song J, Liu S, Zhang Y, Qiu T, Jiang L, Bai J, Yao X, Wang N, Yang G, Sun X
The Science of the total environment 2023 Dec 20;905:167202
The Science of the total environment 2023 Dec 20;905:167202
Histone demethylase KDM4B accelerates the progression of glioblastoma via the epigenetic regulation of MYC stability.
Wang Z, Cai H, Li Z, Sun W, Zhao E, Cui H
Clinical epigenetics 2023 Dec 13;15(1):192
Clinical epigenetics 2023 Dec 13;15(1):192
Squalene epoxidase promotes breast cancer progression by regulating CCNB1 protein stability.
Tuluhong D, Gao H, Li X, Wang L, Zhu Y, Xu C, Wang J, Li H, Li Q, Wang S
Experimental cell research 2023 Dec 1;433(1):113805
Experimental cell research 2023 Dec 1;433(1):113805
Cyclic helix B peptide alleviates proinflammatory cell death and improves functional recovery after traumatic spinal cord injury.
Xu Y, Geng Y, Wang H, Zhang H, Qi J, Li F, Hu X, Chen Y, Si H, Li Y, Wang X, Xu H, Kong J, Cai Y, Wu A, Ni W, Xiao J, Zhou K
Redox biology 2023 Aug;64:102767
Redox biology 2023 Aug;64:102767
O‑GlcNAcylation mediates endometrial cancer progression by regulating the Hippo‑YAP pathway.
Zhai L, Yang X, Dong J, Qian L, Gao Y, Lv Y, Chen L, Chen B, Zhou F
International journal of oncology 2023 Aug;63(2)
International journal of oncology 2023 Aug;63(2)
Glutamine metabolic microenvironment drives M2 macrophage polarization to mediate trastuzumab resistance in HER2-positive gastric cancer.
Hu X, Ma Z, Xu B, Li S, Yao Z, Liang B, Wang J, Liao W, Lin L, Wang C, Zheng S, Wu Q, Huang Q, Yu L, Wang F, Shi M
Cancer communications (London, England) 2023 Aug;43(8):909-937
Cancer communications (London, England) 2023 Aug;43(8):909-937
Adenosine receptor A2b confers ovarian cancer survival and PARP inhibitor resistance through IL-6-STAT3 signalling.
Chi L, Huan L, Zhang C, Wang H, Lu J
Journal of cellular and molecular medicine 2023 Aug;27(15):2150-2164
Journal of cellular and molecular medicine 2023 Aug;27(15):2150-2164
Lnc-PPP2R1B Mediates the Alternative Splicing of PPP2R1B by Interacting and Stabilizing HNRNPLL and Promotes Osteogenesis of MSCs.
Peng S, He T, Liu Y, Zheng L, Zhong Y, Niu Z, Zhang M, Yang S
Stem cell reviews and reports 2023 Aug;19(6):1981-1993
Stem cell reviews and reports 2023 Aug;19(6):1981-1993
Novel treatment and insight for irradiation-induced injuries: Dibucaine ameliorates irradiation-induced testicular injury by inhibiting fatty acid oxidation in primary Leydig cells.
Ran L, Chen Q, Lu X, Gao Z, Cui F, Liu X, Xue B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114903
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114903
AKBA alleviates experimental pancreatitis by inhibiting oxidative stress in Macrophages through the Nrf2/HO-1 pathway.
Yuan C, Dong X, Xu S, Zhu Q, Xu X, Zhang J, Gong W, Ding Y, Pan J, Lu G, Chen W, Xie T, Li B, Xiao W
International immunopharmacology 2023 Aug;121:110501
International immunopharmacology 2023 Aug;121:110501
LMCD1 is involved in tubulointerstitial inflammation in the early phase of renal fibrosis by promoting NFATc1-mediated NLRP3 activation.
Bai Y, Tian M, He P, Zhang Y, Chen J, Zhao Z, Lan J, Zhang B
International immunopharmacology 2023 Aug;121:110362
International immunopharmacology 2023 Aug;121:110362
NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.
Qiu D, Song S, Chen N, Bian Y, Yuan C, Zhang W, Duan H, Shi Y
Cellular signalling 2023 Aug;108:110712
Cellular signalling 2023 Aug;108:110712
Mitochondrial carrier 1 (MTCH1) governs ferroptosis by triggering the FoxO1-GPX4 axis-mediated retrograde signaling in cervical cancer cells.
Wang X, Ji Y, Qi J, Zhou S, Wan S, Fan C, Gu Z, An P, Luo Y, Luo J
Cell death & disease 2023 Aug 8;14(8):508
Cell death & disease 2023 Aug 8;14(8):508
Loss of N-acetylglucosaminyl transferase V is involved in the impaired osteogenic differentiation of bone marrow mesenchymal stem cells.
Liu XP, Li JQ, Li RY, Cao GL, Feng YB, Zhang W
Experimental animals 2023 Aug 7;72(3):413-424
Experimental animals 2023 Aug 7;72(3):413-424
Transcriptional variation in Babesia gibsoni (Wuhan isolate) between in vivo and in vitro cultures in blood stage.
Han Z, Zheng Y, Shi Y, Chen F, Wu C, Wang L, Lu S, Li D, Guan X, He L, Zhao J
Parasites & vectors 2023 Aug 7;16(1):268
Parasites & vectors 2023 Aug 7;16(1):268
Tumor-Associated Extracellular Microvesicles with Fluorine-Modified Carbohydrate Antigens Trigger a Stronger Antitumor Immune Response.
Mo J, Zou Y, Li BH, Li G, Zheng XJ, Liu Y, Ye XS
ACS applied materials & interfaces 2023 Aug 30;15(34):40201-40212
ACS applied materials & interfaces 2023 Aug 30;15(34):40201-40212
LncRNA DGCR5-encoded polypeptide RIP aggravates SONFH by repressing nuclear localization of β-catenin in BMSCs.
Jiang W, Chen Y, Sun M, Huang X, Zhang H, Fu Z, Wang J, Zhang S, Lian C, Tang B, Xiang D, Wang Y, Zhang Y, Jian C, Yang C, Zhang J, Zhang D, Chen T, Zhang J
Cell reports 2023 Aug 29;42(8):112969
Cell reports 2023 Aug 29;42(8):112969
ATF7IP2, a meiosis-specific partner of SETDB1, is required for proper chromosome remodeling and crossover formation during spermatogenesis.
Shao Q, Zhang Y, Liu Y, Shang Y, Li S, Liu L, Wang G, Zhou X, Wang P, Gao J, Zhou J, Zhang L, Wang S
Cell reports 2023 Aug 29;42(8):112953
Cell reports 2023 Aug 29;42(8):112953
Subcellular localization shapes the fate of RNA polymerase III.
Tian K, Wang R, Huang J, Wang H, Ji X
Cell reports 2023 Aug 29;42(8):112941
Cell reports 2023 Aug 29;42(8):112941
POGZ suppresses 2C transcriptional program and retrotransposable elements.
Sun X, Zhang T, Tong B, Cheng L, Jiang W, Sun Y
Cell reports 2023 Aug 29;42(8):112867
Cell reports 2023 Aug 29;42(8):112867
Targeted deletion of von-Hippel-Lindau in the proximal tubule conditions the kidney against early diabetic kidney disease.
Kunke M, Knöfler H, Dahlke E, Zanon Rodriguez L, Böttner M, Larionov A, Saudenova M, Ohrenschall GM, Westermann M, Porubsky S, Bernardes JP, Häsler R, Magnin JL, Koepsell H, Jouret F, Theilig F
Cell death & disease 2023 Aug 26;14(8):562
Cell death & disease 2023 Aug 26;14(8):562
Inhibition of VCP modulates NF-κB signaling pathway to suppress multiple myeloma cell proliferation and osteoclast differentiation.
Wei R, Cao Y, Wu H, Liu X, Jiang M, Luo X, Deng Z, Wang Z, Ke M, Zhu Y, Chen S, Gu C, Yang Y
Aging 2023 Aug 21;15(16):8220-8236
Aging 2023 Aug 21;15(16):8220-8236
HOXA1 participates in VSMC-to-macrophage-like cell transformation via regulation of NF-κB p65 and KLF4: a potential mechanism of atherosclerosis pathogenesis.
Han Z, Hu H, Yin M, Lin Y, Yan Y, Han P, Liu B, Jing B
Molecular medicine (Cambridge, Mass.) 2023 Aug 1;29(1):104
Molecular medicine (Cambridge, Mass.) 2023 Aug 1;29(1):104
Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.
Chang T, Lian Z, Ma S, Liang Z, Ma X, Wen X, Wang Y, Liu R
The Prostate 2023 Apr;83(5):470-486
The Prostate 2023 Apr;83(5):470-486
Muscone promotes functional recovery by facilitating microglia polarization into M2 phenotype through PPAR-γ pathway after ischemic stroke.
Liu F, Cao L, Hu S, Ye H, Wu Q, Wu L
Cellular immunology 2023 Apr;386:104704
Cellular immunology 2023 Apr;386:104704
Loss of RAGE prevents chronic intermittent hypoxia-induced nonalcoholic fatty liver disease via blockade of NF-кB pathway.
Tan H, Hu J, Zuo W, Huang Y, Cui J, Gong F, Bai W
Gene therapy 2023 Apr;30(3-4):278-287
Gene therapy 2023 Apr;30(3-4):278-287
HMGCL-induced β-hydroxybutyrate production attenuates hepatocellular carcinoma via DPP4-mediated ferroptosis susceptibility.
Cui X, Yun X, Sun M, Li R, Lyu X, Lao Y, Qin X, Yu W
Hepatology international 2023 Apr;17(2):377-392
Hepatology international 2023 Apr;17(2):377-392
LINC00669 promotes lung adenocarcinoma growth by stimulating the Wnt/β-catenin signaling pathway.
Zhu J, Cao K, Zhang P, Ma J
Cancer medicine 2023 Apr;12(7):9005-9023
Cancer medicine 2023 Apr;12(7):9005-9023
Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3β/Nrf2 signaling-mediated ferroptosis in vivo and in vitro.
Dong C, Song C, He Z, Song Q, Song T, Liu J, Xiong Y, Su X, Zhou J, Yang S, Liao W
International immunopharmacology 2023 Apr;117:110042
International immunopharmacology 2023 Apr;117:110042
rFGF4 alleviates lipopolysaccharide-induced acute lung injury by inhibiting the TLR4/NF-κB signaling pathway.
Wang X, Zhou L, Ye S, Liu S, Chen L, Cheng Z, Huang Y, Wang B, Pan M, Wang D, Wang L, Lei Z, Im YJ, Li X
International immunopharmacology 2023 Apr;117:109923
International immunopharmacology 2023 Apr;117:109923
YTHDF1 phase separation triggers the fate transition of spermatogonial stem cells by activating the IκB-NF-κB-CCND1 axis.
Fang Q, Tian GG, Wang Q, Liu M, He L, Li S, Wu J
Cell reports 2023 Apr 25;42(4):112403
Cell reports 2023 Apr 25;42(4):112403
Nuclear translocation of cGAS orchestrates VEGF-A-mediated angiogenesis.
Luo J, Lu C, Chen Y, Wu X, Zhu C, Cui W, Yu S, Li N, Pan Y, Zhao W, Yang Q, Yang X
Cell reports 2023 Apr 25;42(4):112328
Cell reports 2023 Apr 25;42(4):112328
Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis.
Ji W, Zhang L, Ma C, Xu X, Li S, Xia H, Zhou W, Liu X
Cell reports 2023 Apr 25;42(4):112327
Cell reports 2023 Apr 25;42(4):112327
A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA.
Lu P, Yang J, Li M, Wen S, Zhang T, Yan C, Liu R, Xiao Y, Wang X, Jiang W
Genome biology 2023 Apr 24;24(1):92
Genome biology 2023 Apr 24;24(1):92
A neuroprotective role of Ufmylation through Atg9 in the aging brain of Drosophila.
Li H, Yu Z, Niu Z, Cheng Y, Wei Z, Cai Y, Ma F, Hu L, Zhu J, Zhang W
Cellular and molecular life sciences : CMLS 2023 Apr 22;80(5):129
Cellular and molecular life sciences : CMLS 2023 Apr 22;80(5):129
Asparagine starvation suppresses histone demethylation through iron depletion.
Jiang J, Srivastava S, Liu S, Seim G, Claude R, Zhong M, Cao S, Davé U, Kapur R, Mosley AL, Zhang C, Wan J, Fan J, Zhang J
iScience 2023 Apr 21;26(4):106425
iScience 2023 Apr 21;26(4):106425
Neofunctionalization of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes.
Ewerling A, Maissl V, Wickstead B, May-Simera HL
iScience 2023 Apr 21;26(4):106410
iScience 2023 Apr 21;26(4):106410
RNA Pol II preferentially regulates ribosomal protein expression by trapping disassociated subunits.
Li Y, Huang J, Bao L, Zhu J, Duan W, Zheng H, Wang H, Jiang Y, Liu W, Zhang M, Yu Y, Yi C, Ji X
Molecular cell 2023 Apr 20;83(8):1280-1297.e11
Molecular cell 2023 Apr 20;83(8):1280-1297.e11
Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma.
Kuang C, Xia M, An G, Liu C, Hu C, Zhang J, Liu Z, Meng B, Su P, Xia J, Guo J, Zhu Y, Liu X, Wu X, Shen Y, Feng X, He Y, Li J, Qiu L, Zhou J, Zhou W
Nature communications 2023 Apr 13;14(1):2093
Nature communications 2023 Apr 13;14(1):2093
Effects of Spatial Expression of Activating Transcription Factor 4 on the Pathogenicity of Two Phenotypes of Bovine Viral Diarrhea Virus by Regulating the Endoplasmic Reticulum-Mediated Autophagy Process.
Wang J, Chen KY, Wang SH, Liu Y, Zhao YQ, Yang L, Yang GH, Wang XJ, Zhu YH, Yin JH, Wang JF
Microbiology spectrum 2023 Apr 13;11(2):e0422522
Microbiology spectrum 2023 Apr 13;11(2):e0422522
Berberine promotes IGF2BP3 ubiquitination by TRIM21 to induce G1/S phase arrest in colorectal cancer cells.
Gui Z, Li J, Li J, Li X, Chen L, Ma Z, Tang X, Gong X, Chai X, Lu F, Li M, Ma H, Li X, Ye X
Chemico-biological interactions 2023 Apr 1;374:110408
Chemico-biological interactions 2023 Apr 1;374:110408
CCPG1 recognizes endoplasmic reticulum luminal proteins for selective ER-phagy.
Ishii S, Chino H, Ode KL, Kurikawa Y, Ueda HR, Matsuura A, Mizushima N, Itakura E
Molecular biology of the cell 2023 Apr 1;34(4):ar29
Molecular biology of the cell 2023 Apr 1;34(4):ar29
Fructose Induces Insulin Resistance of Gestational Diabetes Mellitus in Mice via the NLRP3 Inflammasome Pathway.
Liu Y, Wei Y, Wu L, Lin X, Sun R, Chen H, Shen S, Deng G
Frontiers in nutrition 2022;9:839174
Frontiers in nutrition 2022;9:839174
Guanxinping Tablets Inhibit ET-1-Induced Proliferation and Migration of MOVAS by Suppressing Activated PI3K/Akt/NF-κB Signaling Cascade.
Wu YY, Huang YL, Dai B, Liu JW, Han X
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9485463
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9485463
Qingfei Tongluo Formula Mitigates Mycoplasma pneumoniae Infection via the PERK Signaling Pathway.
Liu X, Wang M, Kan Q, Lin Y, Jiang Z
Disease markers 2022;2022:9340353
Disease markers 2022;2022:9340353
Inhibition of APE1 Expression Enhances the Antitumor Activity of Olaparib in Triple-Negative Breast Cancer.
Jian D, Li XM, Dai N, Liang DD, Zhang G, Mao CY, Wang D, Song GB, Li MX, Luo H
Evidence-based complementary and alternative medicine : eCAM 2022;2022:6048017
Evidence-based complementary and alternative medicine : eCAM 2022;2022:6048017
Deletion of ACLY Disrupts Histone Acetylation and IL-10 Secretion in Trophoblasts, Which Inhibits M2 Polarization of Macrophages: A Possible Role in Recurrent Spontaneous Abortion.
Chen X, Song QL, Li ZH, Ji R, Wang JY, Ge C, Xiao ZN, Guo DY, Yang J
Oxidative medicine and cellular longevity 2022;2022:5216786
Oxidative medicine and cellular longevity 2022;2022:5216786
Maltol Promotes Mitophagy and Inhibits Oxidative Stress via the Nrf2/PINK1/Parkin Pathway after Spinal Cord Injury.
Mao Y, Du J, Chen X, Al Mamun A, Cao L, Yang Y, Mubwandarikwa J, Zaeem M, Zhang W, Chen Y, Dai Y, Xiao J, Ye K
Oxidative medicine and cellular longevity 2022;2022:1337630
Oxidative medicine and cellular longevity 2022;2022:1337630
Downregulation of lncRNA APCDD1L-AS1 due to DNA hypermethylation and loss of VHL protein expression promotes the progression of clear cell renal cell carcinoma.
Yang W, Zhou J, Zhang Z, Zhang K, Xu Y, Li L, Cai L, Gong Y, Gong K
International journal of biological sciences 2022;18(6):2583-2596
International journal of biological sciences 2022;18(6):2583-2596
Yap is essential for uterine decidualization through Rrm2/GSH/ROS pathway in response to Bmp2.
Yu HF, Yang ZQ, Xu MY, Huang JC, Yue ZP, Guo B
International journal of biological sciences 2022;18(6):2261-2276
International journal of biological sciences 2022;18(6):2261-2276
HB-EGF induces mitochondrial dysfunction via estrogen hypersecretion in granulosa cells dependent on cAMP-PKA-JNK/ERK-Ca(2+)-FOXO1 pathway.
Huang JC, Duan CC, Jin S, Sheng CB, Wang YS, Yue ZP, Guo B
International journal of biological sciences 2022;18(5):2047-2059
International journal of biological sciences 2022;18(5):2047-2059
Caspase-1-mediated extracellular vesicles derived from pyroptotic alveolar macrophages promote inflammation in acute lung injury.
Qin X, Zhou Y, Jia C, Chao Z, Qin H, Liang J, Liu X, Liu Z, Sun T, Yuan Y, Zhang H
International journal of biological sciences 2022;18(4):1521-1538
International journal of biological sciences 2022;18(4):1521-1538
B16 Membrane-Coated Vesicles for Combined Photodynamic Therapy and Immunotherapy Shift Immune Microenvironment of Melanoma.
Wang Y, Zhao Z, Liu C, Hao M, Kong C, Zhao X, Gao Y, Zhang Y, Cui W, Zhang C, Jiang J
International journal of nanomedicine 2022;17:855-868
International journal of nanomedicine 2022;17:855-868
Superparamagnetic Iron Oxide Nanoparticles Protect Human Gingival Fibroblasts from Porphyromonas gingivalis Invasion and Inflammatory Stimulation.
Chen Y, Zhang Q, Qin X, Li J, Zhao Y, Xia Y
International journal of nanomedicine 2022;17:45-60
International journal of nanomedicine 2022;17:45-60
CCL25 Inhibition Alleviates Sepsis-Induced Acute Lung Injury and Inflammation.
Xia D, Wang S, Liu A, Li L, Zhou P, Xu S
Infection and drug resistance 2022;15:3309-3321
Infection and drug resistance 2022;15:3309-3321
DNA 6mA Demethylase ALKBH1 Orchestrates Fatty Acid Metabolism and Suppresses Diet-Induced Hepatic Steatosis.
Luo L, Liu Y, Nizigiyimana P, Ye M, Xiao Y, Guo Q, Su T, Luo X, Huang Y, Zhou H
Cellular and molecular gastroenterology and hepatology 2022;14(6):1213-1233
Cellular and molecular gastroenterology and hepatology 2022;14(6):1213-1233
Resveratrol reduces inflammatory response and detrimental effects in chronic cerebral hypoperfusion by down-regulating stimulator of interferon genes/TANK-binding kinase 1/interferon regulatory factor 3 signaling.
Kang N, Shi Y, Song J, Gao F, Fan M, Jin W, Gao Y, Lv P
Frontiers in aging neuroscience 2022;14:868484
Frontiers in aging neuroscience 2022;14:868484
Transcriptional and H3K27ac related genome profiles in oral squamous cell carcinoma cells treated with metformin.
Liu S, Shi C, Hou X, Tian X, Li C, Ma X, Wang X, Gao P
Journal of Cancer 2022;13(6):1859-1870
Journal of Cancer 2022;13(6):1859-1870
The BcLAE1 is involved in the regulation of ABA biosynthesis in Botrytis cinerea TB-31.
Wei Z, Shu D, Sun Q, Chen DB, Li ZM, Luo D, Yang J, Tan H
Frontiers in microbiology 2022;13:969499
Frontiers in microbiology 2022;13:969499
Loss of Cep72 affects the morphology of spermatozoa in mice.
Chen Z, Xu Y, Ma D, Li C, Yu Z, Liu C, Jin T, Du Z, Li Z, Sun Q, Xu Y, Liu R, Wu Y, Luo M
Frontiers in physiology 2022;13:948965
Frontiers in physiology 2022;13:948965
EST12 regulates Myc expression and enhances anti-mycobacterial inflammatory response via RACK1-JNK-AP1-Myc immune pathway.
Wu J, Luo FL, Xie Y, Xiong H, Gao Y, Liu G, Zhang XL
Frontiers in immunology 2022;13:943174
Frontiers in immunology 2022;13:943174
Acetyl-11-Keto-Beta Boswellic Acid (AKBA) Protects Lens Epithelial Cells Against H(2)O(2)-Induced Oxidative Injury and Attenuates Cataract Progression by Activating Keap1/Nrf2/HO-1 Signaling.
Yang T, Lin X, Li H, Zhou X, Fan F, Yang J, Luo Y, Liu X
Frontiers in pharmacology 2022;13:927871
Frontiers in pharmacology 2022;13:927871
GSK3β-dependent lysosome biogenesis: An effective pathway to mitigate renal fibrosis with LM49.
Ren J, Wei H, Sun J, Feng X, Zhang Y, Yuan H, Miao J, Qi X, Qiao Y, Xiao B, Li Q
Frontiers in pharmacology 2022;13:925489
Frontiers in pharmacology 2022;13:925489
Cyclophosphamide Induces the Ferroptosis of Tumor Cells Through Heme Oxygenase-1.
Shi H, Hou B, Li H, Zhou H, Du B
Frontiers in pharmacology 2022;13:839464
Frontiers in pharmacology 2022;13:839464
Characterization and subcellular localization of Alongshan virus proteins.
Zhao Y, Wu P, Liu L, Ma B, Pan M, Huang Y, Du N, Yu H, Sui L, Wang ZD, Hou Z, Liu Q
Frontiers in microbiology 2022;13:1000322
Frontiers in microbiology 2022;13:1000322
PPAR-γ integrates obesity and adipocyte clock through epigenetic regulation of Bmal1.
Wang S, Lin Y, Gao L, Yang Z, Lin J, Ren S, Li F, Chen J, Wang Z, Dong Z, Sun P, Wu B
Theranostics 2022;12(4):1589-1606
Theranostics 2022;12(4):1589-1606
Reversion of methionine addiction of osteosarcoma cells to methionine independence results in loss of malignancy, modulation of the epithelial-mesenchymal phenotype and alteration of histone-H3 lysine-methylation.
Aoki Y, Han Q, Tome Y, Yamamoto J, Kubota Y, Masaki N, Obara K, Hamada K, Wang JD, Inubushi S, Bouvet M, Clarke SG, Nishida K, Hoffman RM
Frontiers in oncology 2022;12:1009548
Frontiers in oncology 2022;12:1009548
Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway.
Sun F, Zhou JL, Wei SX, Jiang ZW, Peng H
PeerJ 2022;10:e13319
PeerJ 2022;10:e13319
Stimulator of Interferon Genes (STING) Promotes Staphylococcus aureus-Induced Extracellular Traps Formation via the ROS-ERK Signaling Pathway.
Liu ZZ, Chen W, Zhou CK, Ma K, Gao Y, Yang YJ
Frontiers in cell and developmental biology 2022;10:836880
Frontiers in cell and developmental biology 2022;10:836880
Manganese-Induced Oxidative Stress Contributes to Intestinal Lipid Deposition via the Deacetylation of PPARγ at K339 by SIRT1.
Lv WH, Zhao T, Pantopoulos K, Chen GH, Wei XL, Zhang DG, Luo Z
Antioxidants & redox signaling 2022 Sep;37(7-9):417-436
Antioxidants & redox signaling 2022 Sep;37(7-9):417-436
Biosynthesis of a water solubility-enhanced succinyl glucoside derivative of luteolin and its neuroprotective effect.
Chen L, Chang S, Zhao L, Li B, Zhang S, Yun C, Wu X, Meng J, Li G, Guo S, Duan J
Microbial biotechnology 2022 Sep;15(9):2401-2410
Microbial biotechnology 2022 Sep;15(9):2401-2410
Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.
Shen Y, Fan X, Qu Y, Tang M, Huang Y, Peng Y, Fu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154339
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154339
TRIM36 inhibits tumorigenesis through the Wnt/β-catenin pathway and promotes caspase-dependent apoptosis in hepatocellular carcinoma.
Tong Q, Yi M, Kong P, Xu L, Huang W, Niu Y, Gan X, Zhan H, Tian R, Yan D
Cancer cell international 2022 Sep 6;22(1):278
Cancer cell international 2022 Sep 6;22(1):278
TRIM46 aggravated high glucose-induced hyper permeability and inflammatory response in human retinal capillary endothelial cells by promoting IκBα ubiquitination.
Shen H, Gong Q, Zhang J, Wang H, Qiu Q, Zhang J, Luo D
Eye and vision (London, England) 2022 Sep 5;9(1):35
Eye and vision (London, England) 2022 Sep 5;9(1):35
The transcriptional repressors VAL1 and VAL2 mediate genome-wide recruitment of the CHD3 chromatin remodeler PICKLE in Arabidopsis.
Liang Z, Yuan L, Xiong X, Hao Y, Song X, Zhu T, Yu Y, Fu W, Lei Y, Xu J, Liu J, Li JF, Li C
The Plant cell 2022 Sep 27;34(10):3915-3935
The Plant cell 2022 Sep 27;34(10):3915-3935
Fatostatin inhibits SREBP2-mediated cholesterol uptake via LDLR against selective estrogen receptor α modulator-induced hepatic lipid accumulation.
Li M, Lu Q, Zhu Y, Fan X, Zhao W, Zhang L, Jiang Z, Yu Q
Chemico-biological interactions 2022 Sep 25;365:110091
Chemico-biological interactions 2022 Sep 25;365:110091
Role of PARP-1 in Human Cytomegalovirus Infection and Functional Partners Encoded by This Virus.
Zhang W, Guo J, Chen Q
Viruses 2022 Sep 15;14(9)
Viruses 2022 Sep 15;14(9)
1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42) inhibits cell proliferation and induces apoptosis via inhibiting ALK and its downstream pathways in Karpas299 cells.
Chang X, Wang J, Bian J, Liu Z, Guo M, Li Z, Wu Y, Zhai X, Zuo D
Toxicology and applied pharmacology 2022 Sep 1;450:116156
Toxicology and applied pharmacology 2022 Sep 1;450:116156
MCTR1 inhibits ferroptosis by promoting NRF2 expression to attenuate hepatic ischemia-reperfusion injury.
Ye J, Peng J, Liu K, Zhang T, Huang W
American journal of physiology. Gastrointestinal and liver physiology 2022 Sep 1;323(3):G283-G293
American journal of physiology. Gastrointestinal and liver physiology 2022 Sep 1;323(3):G283-G293
Notch4 affects the proliferation and differentiation of deer antler chondrocytes through the Smad3/lncRNA27785.1 axis.
Chen DY, Yang M, Sun ZT, Song MM, Yao HB, Long GH, Hu W
Cellular signalling 2022 Oct;98:110429
Cellular signalling 2022 Oct;98:110429
A novel O(2)- (2,4-dinitrophenyl) diazeniumdiolate inhibits hepatocellular carcinoma migration, invasion, and EMT through the Wnt/β-catenin pathway.
Xing Y, Hu Y, Zou H, Xie H, Jiang T, Liu L
Toxicology in vitro : an international journal published in association with BIBRA 2022 Oct;84:105456
Toxicology in vitro : an international journal published in association with BIBRA 2022 Oct;84:105456
MARCH1 promotes the growth and maintaining of stem cell-like characteristics of gastric cancer cells by activating the Wnt/β-catenin signaling pathway.
Liang W, Zhang T, Huo J, Yang J
Tissue & cell 2022 Oct;78:101895
Tissue & cell 2022 Oct;78:101895
Sestrin2 attenuates renal damage by regulating Hippo pathway in diabetic nephropathy.
Bian Y, Shi C, Song S, Mu L, Wu M, Qiu D, Dong J, Zhang W, Yuan C, Wang D, Zhou Z, Dong X, Shi Y
Cell and tissue research 2022 Oct;390(1):93-112
Cell and tissue research 2022 Oct;390(1):93-112
SAC3D1 activates Wnt/β‑catenin signalling in hepatocellular carcinoma.
Wang H, Shi X
Molecular medicine reports 2022 Oct;26(4)
Molecular medicine reports 2022 Oct;26(4)
Effect of propiconazole on neutrophil extracellular traps formation: Assessing the role of autophagy.
Ma Y, Li S, Ye S, Hu D, Luo S, Wei L, Xiao F
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Oct;168:113354
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Oct;168:113354
Fucoidan inhibits EGFR redistribution and potentiates sorafenib to overcome sorafenib-resistant hepatocellular carcinoma.
Luo J, Li L, Zhu Z, Chang B, Deng F, Wang D, Lu X, Zuo D, Chen Q, Zhou J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113602
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113602
CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment.
Pan Z, Xu T, Bao L, Hu X, Jin T, Chen J, Chen J, Qian Y, Lu X, Li L, Zheng G, Zhang Y, Zou X, Song F, Zheng C, Jiang L, Wang J, Tan Z, Huang P, Ge M
Molecular cancer 2022 Oct 3;21(1):190
Molecular cancer 2022 Oct 3;21(1):190
ITGA2 overexpression inhibits DNA repair and confers sensitivity to radiotherapies in pancreatic cancer.
Zhou C, Li S, Bin K, Qin G, Pan P, Ren D, Zhao Y, Xia W, Chen J, Liu J, Wu H, Zhou Y
Cancer letters 2022 Oct 28;547:215855
Cancer letters 2022 Oct 28;547:215855
An assembly-inducing PDC enabling the efficient nuclear delivery of nucleic acid for cancer stem-like cell suppression.
Wang D, Tian Y, Zhang Y, Sun X, Wu Y, Liu R, Zeng F, Du J, Hu K
Nanoscale 2022 Oct 27;14(41):15384-15392
Nanoscale 2022 Oct 27;14(41):15384-15392
RBCK1 is an endogenous inhibitor for triple negative breast cancer via hippo/YAP axis.
Li Z, Su P, Ding Y, Gao H, Yang H, Li X, Yang X, Xia Y, Zhang C, Fu M, Wang D, Zhang Y, Zhuo S, Zhu J, Zhuang T
Cell communication and signaling : CCS 2022 Oct 24;20(1):164
Cell communication and signaling : CCS 2022 Oct 24;20(1):164
Malvidin protects against lipopolysaccharide-induced acute liver injury in mice via regulating Nrf2 and NLRP3 pathways and suppressing apoptosis and autophagy.
Fan H, Cui J, Liu F, Zhang W, Yang H, He N, Dong Z, Dong J
European journal of pharmacology 2022 Oct 15;933:175252
European journal of pharmacology 2022 Oct 15;933:175252
The Effect of Circumscribed Exposure to the Pan-Aurora Kinase Inhibitor VX-680 on Proliferating Euploid Cells.
Liu X, Shi Q, Choudhry N, Zhang T, Liu H, Zhang S, Zhang J, Yang D
International journal of molecular sciences 2022 Oct 11;23(20)
International journal of molecular sciences 2022 Oct 11;23(20)
CGG repeat expansion in NOTCH2NLC causes mitochondrial dysfunction and progressive neurodegeneration in Drosophila model.
Yu J, Liufu T, Zheng Y, Xu J, Meng L, Zhang W, Yuan Y, Hong D, Charlet-Berguerand N, Wang Z, Deng J
Proceedings of the National Academy of Sciences of the United States of America 2022 Oct 11;119(41):e2208649119
Proceedings of the National Academy of Sciences of the United States of America 2022 Oct 11;119(41):e2208649119
Difenoconazole disrupts the blood-brain barrier and results in neurotoxicity in carp by inhibiting the Nrf2 pathway mediated ROS accumulation.
Liu F, Wang Y, Chen L, Bello BK, Zhang T, Yang H, Li X, Pan E, Feng H, Dong J
Ecotoxicology and environmental safety 2022 Oct 1;244:114081
Ecotoxicology and environmental safety 2022 Oct 1;244:114081
CircNFIX regulates chondrogenesis and cartilage homeostasis by targeting the miR758-3p/KDM6A axis.
Liao H, Tu Q, Kang Y, Mao G, Li Z, Hu S, Sheng P, Wang X, Xu Y, Long D, Xu Y, Kang Y, Zhang Z
Cell proliferation 2022 Nov;55(11):e13302
Cell proliferation 2022 Nov;55(11):e13302
Stabilizing and upregulating Axin with tankyrase inhibitor reverses 5-fluorouracil chemoresistance and proliferation by targeting the WNT/caveolin-1 axis in colorectal cancer cells.
Luo F, Li J, Liu J, Liu K
Cancer gene therapy 2022 Nov;29(11):1707-1719
Cancer gene therapy 2022 Nov;29(11):1707-1719
Small immune effectors coordinate peptidoglycan-derived immunity to regulate intestinal bacteria in shrimp.
Liu PP, Wei Z, Cheng ZH, Wang XW
PLoS pathogens 2022 Nov;18(11):e1010967
PLoS pathogens 2022 Nov;18(11):e1010967
A systems biological analysis of the ATF4-GADD34-CHOP regulatory triangle upon endoplasmic reticulum stress.
Márton M, Bánhegyi G, Gyöngyösi N, Kálmán EÉ, Pettkó-Szandtner A, Káldi K, Kapuy O
FEBS open bio 2022 Nov;12(11):2065-2082
FEBS open bio 2022 Nov;12(11):2065-2082
Grossamide attenuates inflammation by balancing macrophage polarization through metabolic reprogramming of macrophages in mice.
Zhao W, Xu D, Hong W, Zhang L, Wu Q, Gao M, Wang J
International immunopharmacology 2022 Nov;112:109190
International immunopharmacology 2022 Nov;112:109190
Capsaicin suppresses hepatocarcinogenesis by inhibiting the stemness of hepatic progenitor cells via SIRT1/SOX2 signaling pathway.
Xie ZQ, Li HX, Hou XJ, Huang MY, Zhu ZM, Wei LX, Tang CX
Cancer medicine 2022 Nov;11(22):4283-4296
Cancer medicine 2022 Nov;11(22):4283-4296
Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling.
Gao S, Yang Q, Liu Z, Kong W, Chen J, Li X, Peng Y, Bao M, Bian X, Zhang Y, Jiang Q, Li Z, Zhang Y, Yan F, Ye J
Clinical science (London, England : 1979) 2022 Nov 30;136(22):1711-1730
Clinical science (London, England : 1979) 2022 Nov 30;136(22):1711-1730
Regulation of ZO-1 on β-catenin mediates sulforaphane suppressed colorectal cancer stem cell properties in colorectal cancer.
Chen Y, Tang L, Ye X, Chen Y, Shan E, Han H, Zhong C
Food & function 2022 Nov 28;13(23):12363-12370
Food & function 2022 Nov 28;13(23):12363-12370
Taurine stimulates protein synthesis and proliferation of C2C12 myoblast cells through the PI3K-ARID4B-mTOR pathway.
Hao Q, Wang L, Zhang M, Wang Z, Li M, Gao X
The British journal of nutrition 2022 Nov 28;128(10):1875-1886
The British journal of nutrition 2022 Nov 28;128(10):1875-1886
O-GlcNAcylation of SIRT1 Protects against Cold Stress-Induced Skeletal Muscle Damage via Amelioration of Mitochondrial Homeostasis.
Cao Y, Zhang M, Li Y, Lu J, Zhou W, Li X, Shi H, Xu B, Li S
International journal of molecular sciences 2022 Nov 22;23(23)
International journal of molecular sciences 2022 Nov 22;23(23)
Naringenin Promotes Myotube Formation and Maturation for Cultured Meat Production.
Yan Q, Fei Z, Li M, Zhou J, Du G, Guan X
Foods (Basel, Switzerland) 2022 Nov 22;11(23)
Foods (Basel, Switzerland) 2022 Nov 22;11(23)
Deficiency of CD93 exacerbates inflammation-induced activation and migration of BV2 microglia by regulating the TAK1/NF-κB pathway.
Hong X, Xia M, Zhang Q, Zhao T, Zhang Y, Qian Z, Bao J, Li H
Neuroscience letters 2022 Nov 20;791:136914
Neuroscience letters 2022 Nov 20;791:136914
Overexpression of Tfap2a in Mouse Oocytes Impaired Spindle and Chromosome Organization.
Lin J, Ji Z, Di Z, Zhang Y, Yan C, Zeng S
International journal of molecular sciences 2022 Nov 19;23(22)
International journal of molecular sciences 2022 Nov 19;23(22)
The H2A.Z-KDM1A complex promotes tumorigenesis by localizing in the nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells.
Wang Q, Qi Y, Xiong F, Wang D, Wang B, Chen Y
BMC cancer 2022 Nov 11;22(1):1166
BMC cancer 2022 Nov 11;22(1):1166
Leonurine inhibits the TXNIP/NLRP3 and NF-κB pathways via Nrf2 activation to alleviate carrageenan-induced pleurisy in mice.
Yan K, Hu J, Hou T, Ci X, Peng L
Phytotherapy research : PTR 2022 May;36(5):2161-2172
Phytotherapy research : PTR 2022 May;36(5):2161-2172
Mitochondrial transcription factor B2 overexpression increases M2 macrophage infiltration via cytosolic mitochondrial DNA-stimulated Interleukin-6 secretion in ovarian cancer.
Wu W, Zhou S, Liu T, Liang D
Bioengineered 2022 May;13(5):12211-12223
Bioengineered 2022 May;13(5):12211-12223
Characterization of the Eimeria tenella rhoptry protein with a nuclear localization sequence (EtROP30).
Bingxiang W, Ningning Z, Yakun W, Lingyu S, Hongmei L, Zhang X, Zhao X
Parasitology research 2022 May;121(5):1507-1516
Parasitology research 2022 May;121(5):1507-1516
Genome-wide gain-of-function screening identifies EZH2 mediating resistance to PI3Kα inhibitors in oesophageal squamous cell carcinoma.
Xing H, Gao M, Wang Y, Zhang X, Shi J, Wang X, Liu X, Ma Q, Kong X, Yang C, Ding J, Meng L
Clinical and translational medicine 2022 May;12(5):e835
Clinical and translational medicine 2022 May;12(5):e835
POU6F1 cooperates with RORA to suppress the proliferation of lung adenocarcinoma by downregulation HIF1A signaling pathway.
Xiao W, Geng W, Zhou M, Xu J, Wang S, Huang Q, Sun Y, Li Y, Yang G, Jin Y
Cell death & disease 2022 May 3;13(5):427
Cell death & disease 2022 May 3;13(5):427
Isoleucine stimulates mTOR and SREBP-1c gene expression for milk synthesis in mammary epithelial cells through BRG1-mediated chromatin remodelling.
Hao Q, Wang Z, Wang L, Han M, Zhang M, Gao X
The British journal of nutrition 2022 May 20;:1-11
The British journal of nutrition 2022 May 20;:1-11
Dysregulated lipid metabolism blunts the sensitivity of cancer cells to EZH2 inhibitor.
Zhang T, Guo Z, Huo X, Gong Y, Li C, Huang J, Wang Y, Feng H, Ma X, Jiang C, Yin Q, Xue L
EBioMedicine 2022 Mar;77:103872
EBioMedicine 2022 Mar;77:103872
Attenuation of Activated eIF2α Signaling by ISRIB Treatment After Spinal Cord Injury Improves Locomotor Function.
Chang L, Liu X, Chen J, Liu H, Wang G, Wang G, Liao X, Shen X
Journal of molecular neuroscience : MN 2022 Mar;72(3):585-597
Journal of molecular neuroscience : MN 2022 Mar;72(3):585-597
iASPP is essential for HIF-1α stabilization to promote angiogenesis and glycolysis via attenuating VHL-mediated protein degradation.
Zhao D, Zheng S, Wang X, Liu H, Zhao K, Li L, Hu Y
Oncogene 2022 Mar;41(13):1944-1958
Oncogene 2022 Mar;41(13):1944-1958
DNA damage-induced translocation of mitochondrial factor HIGD1A into the nucleus regulates homologous recombination and radio/chemo-sensitivity.
Chen B, Xu F, Gao Y, Hu G, Zhu K, Lu H, Xu A, Chen S, Wu L, Zhao G
Oncogene 2022 Mar;41(13):1918-1930
Oncogene 2022 Mar;41(13):1918-1930
Inhibition of translocator protein 18 kDa suppressed the progression of glioma via the ELAV-like RNA-binding protein 1/MAPK-activated protein kinase 3 axis.
Wang J, Ren P, Zeng Z, Ma L, Li Y, Zhang H, Guo W
Bioengineered 2022 Mar;13(3):7457-7470
Bioengineered 2022 Mar;13(3):7457-7470
Methionine and leucine induce ARID1A degradation to promote mTOR expression and milk synthesis in mammary epithelial cells.
Qi H, Wang L, Zhang M, Wang Z, Gao X, Li M
The Journal of nutritional biochemistry 2022 Mar;101:108924
The Journal of nutritional biochemistry 2022 Mar;101:108924
Gut microbiota shapes social dominance through modulating HDAC2 in the medial prefrontal cortex.
Wang T, Xu J, Xu Y, Xiao J, Bi N, Gu X, Wang HL
Cell reports 2022 Mar 8;38(10):110478
Cell reports 2022 Mar 8;38(10):110478
Bisphenol A drives di(2-ethylhexyl) phthalate promoting thyroid tumorigenesis via regulating HDAC6/PTEN and c-MYC signaling.
Zhang X, Guo N, Jin H, Liu R, Zhang Z, Cheng C, Fan Z, Zhang G, Xiao M, Wu S, Zhao Y, Lu X
Journal of hazardous materials 2022 Mar 5;425:127911
Journal of hazardous materials 2022 Mar 5;425:127911
LPS/Bcl3/YAP1 signaling promotes Sox9(+)HNF4α(+) hepatocyte-mediated liver regeneration after hepatectomy.
Shao C, Jing Y, Zhao S, Yang X, Hu Y, Meng Y, Huang Y, Ye F, Gao L, Liu W, Sheng D, Li R, Zhang X, Wei L
Cell death & disease 2022 Mar 28;13(3):277
Cell death & disease 2022 Mar 28;13(3):277
HMGB3 promotes PARP inhibitor resistance through interacting with PARP1 in ovarian cancer.
Ma H, Qi G, Han F, Lu W, Peng J, Li R, Yan S, Yuan C, Kong B
Cell death & disease 2022 Mar 24;13(3):263
Cell death & disease 2022 Mar 24;13(3):263
Targeting macrophage TFEB-14-3-3 epsilon Interface by naringenin inhibits abdominal aortic aneurysm.
Jia Y, Zhang L, Liu Z, Mao C, Ma Z, Li W, Yu F, Wang Y, Huang Y, Zhang W, Zheng J, Wang X, Xu Q, Zhang J, Feng W, Yun C, Liu C, Sun J, Fu Y, Cui Q, Kong W
Cell discovery 2022 Mar 1;8(1):21
Cell discovery 2022 Mar 1;8(1):21
Recruitment of DNA to tumor-derived microvesicles.
Clancy JW, Sheehan CS, Boomgarden AC, D'Souza-Schorey C
Cell reports 2022 Mar 1;38(9):110443
Cell reports 2022 Mar 1;38(9):110443
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix.
Kay EJ, Paterson K, Riera-Domingo C, Sumpton D, Däbritz JHM, Tardito S, Boldrini C, Hernandez-Fernaud JR, Athineos D, Dhayade S, Stepanova E, Gjerga E, Neilson LJ, Lilla S, Hedley A, Koulouras G, McGregor G, Jamieson C, Johnson RM, Park M, Kirschner K, Miller C, Kamphorst JJ, Loayza-Puch F, Saez-Rodriguez J, Mazzone M, Blyth K, Zagnoni M, Zanivan S
Nature metabolism 2022 Jun;4(6):693-710
Nature metabolism 2022 Jun;4(6):693-710
Overexpression of G Protein-Coupled Receptor 40 Protects Obesity-Induced Cardiomyopathy Through the SIRT1/LKB1/AMPK Pathway.
Li SN, Yu YL, Wang BY, Qiao SY, Hu MM, Wang H, Fu CN, Dong B
Human gene therapy 2022 Jun;33(11-12):598-613
Human gene therapy 2022 Jun;33(11-12):598-613
Mammalian PERIOD2 regulates H2A.Z incorporation in chromatin to orchestrate circadian negative feedback.
Tartour K, Andriani F, Folco EG, Letkova D, Schneider R, Saidi I, Sato T, Welz PS, Benitah SA, Allier C, Padmanabhan K
Nature structural & molecular biology 2022 Jun;29(6):549-562
Nature structural & molecular biology 2022 Jun;29(6):549-562
Deacetylation of Caveolin-1 by Sirt6 induces autophagy and retards high glucose-stimulated LDL transcytosis and atherosclerosis formation.
Zhao Y, Jia X, Yang X, Bai X, Lu Y, Zhu L, Cheng W, Shu M, Zhu Y, Du X, Wang L, Shu Y, Song Y, Jin S
Metabolism: clinical and experimental 2022 Jun;131:155162
Metabolism: clinical and experimental 2022 Jun;131:155162
Dietary curcumin supplementation ameliorates placental inflammation in rats with intra-uterine growth retardation by inhibiting the NF-κB signaling pathway.
Qi L, Jiang J, Yu G, Zhang X, Qi X, Zhang J, Zhang L, Wang T
The Journal of nutritional biochemistry 2022 Jun;104:108973
The Journal of nutritional biochemistry 2022 Jun;104:108973
A novel ALG10/TGF-β positive regulatory loop contributes to the stemness of colorectal cancer.
Xu X, Wang H, Li X, Duan X, Wang Y
Aging 2022 Jun 9;14(11):4858-4873
Aging 2022 Jun 9;14(11):4858-4873
Interaction of Nucleolin with the Fusion Protein of Avian Metapneumovirus Subgroup C Contributes to Viral Replication.
Wang D, Hou L, Zhu N, Yang X, Zhou J, Cui Y, Guo J, Feng X, Liu J
Viruses 2022 Jun 27;14(7)
Viruses 2022 Jun 27;14(7)
Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival.
Chen Z, Wu H, Yang J, Li B, Ding J, Cheng S, Bsoul N, Zhang C, Li J, Liu H, Lin D, Gao W
Communications biology 2022 Jun 22;5(1):616
Communications biology 2022 Jun 22;5(1):616
The PRMT5-LSD1 axis confers Slug dual transcriptional activities and promotes breast cancer progression.
Zhang J, Fan X, Zhou Y, Chen L, Rao H
Journal of experimental & clinical cancer research : CR 2022 Jun 2;41(1):191
Journal of experimental & clinical cancer research : CR 2022 Jun 2;41(1):191
Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress.
Lu J, Fu S, Dai J, Hu J, Li S, Ji H, Wang Z, Yu J, Bao J, Xu B, Guo J, Yang H
Journal of Zhejiang University. Science. B 2022 Jun 15;23(6):461-480
Journal of Zhejiang University. Science. B 2022 Jun 15;23(6):461-480
TAZ ameliorates the microglia-mediated inflammatory response via the Nrf2-ROS-NF-κB pathway.
Huang JC, Yue ZP, Yu HF, Yang ZQ, Wang YS, Guo B
Molecular therapy. Nucleic acids 2022 Jun 14;28:435-449
Molecular therapy. Nucleic acids 2022 Jun 14;28:435-449
Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration.
Jhanji M, Rao CN, Massey JC, Hope MC 3rd, Zhou X, Keene CD, Ma T, Wyatt MD, Stewart JA, Sajish M
Nature communications 2022 Jun 10;13(1):3244
Nature communications 2022 Jun 10;13(1):3244
Treatment of Membranous Nephropathy by Disulfiram through Inhibition of Podocyte Pyroptosis.
Lv D, Jiang S, Zhang M, Zhu X, Yang F, Wang H, Li S, Liu F, Zeng C, Qin W, Li L, Liu Z
Kidney diseases (Basel, Switzerland) 2022 Jul;8(4):308-318
Kidney diseases (Basel, Switzerland) 2022 Jul;8(4):308-318
NLRP3 inflammasome triggers interleukin-37 release from human monocytes.
Gritsenko A, Díaz-Pino R, López-Castejón G
European journal of immunology 2022 Jul;52(7):1141-1157
European journal of immunology 2022 Jul;52(7):1141-1157
Berberine protects against palmitate induced beta cell injury via promoting mitophagy.
Li M, She J, Ma L, Ma L, Ma X, Zhai J
Genes & genomics 2022 Jul;44(7):867-878
Genes & genomics 2022 Jul;44(7):867-878
Vibrio splendidus flagellin C binds tropomodulin to induce p38 MAPK-mediated p53-dependent coelomocyte apoptosis in Echinodermata.
Dai F, Guo M, Shao Y, Li C
The Journal of biological chemistry 2022 Jul;298(7):102091
The Journal of biological chemistry 2022 Jul;298(7):102091
Procyanidins and its metabolites by gut microbiome improves insulin resistance in gestational diabetes mellitus mice model via regulating NF-κB and NLRP3 inflammasome pathway.
Liu Y, Sun R, Lin X, Wu L, Chen H, Shen S, Li Y, Wei Y, Deng G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113078
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113078
Design, synthesis and biological evaluation of (R)-5-methylpyrrolidin-2-ones as p300 bromodomain inhibitors with Anti-Tumor activities in multiple tumor lines.
Liu R, Yang H, Chen Z, Zhou K, Shi Q, Li J, Huang Y, Huang X, Li Y
Bioorganic chemistry 2022 Jul;124:105803
Bioorganic chemistry 2022 Jul;124:105803
Maackiain protects against sepsis via activating AMPK/Nrf2/HO-1 pathway.
Bai X, Zhu Y, Jie J, Li D, Song L, Luo J
International immunopharmacology 2022 Jul;108:108710
International immunopharmacology 2022 Jul;108:108710
The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice.
Zhang XZ, Wei LL, Jin HJ, Zhang XH, Chen SR
Cell reports 2022 Jul 5;40(1):111049
Cell reports 2022 Jul 5;40(1):111049
T-2 Toxin Induces Apoptotic Cell Death and Protective Autophagy in Mouse Microglia BV2 Cells.
Sun T, Zhang Q, Li M, Tang S, Dai C
Journal of fungi (Basel, Switzerland) 2022 Jul 22;8(8)
Journal of fungi (Basel, Switzerland) 2022 Jul 22;8(8)
Alphaherpesvirus US3 protein-mediated inhibition of the m6A mRNA methyltransferase complex.
Jansens RJJ, Verhamme R, Mirza AH, Olarerin-George A, Van Waesberghe C, Jaffrey SR, Favoreel HW
Cell reports 2022 Jul 19;40(3):111107
Cell reports 2022 Jul 19;40(3):111107
Andrographolide protects bone marrow mesenchymal stem cells against glucose and serum deprivation under hypoxia via the NRF2 signaling pathway.
Sun Y, Xu H, Tan B, Yi Q, Liu H, Chen T, Xiang H, Wang R, Xie Q, Tian J, Zhu J
Stem cell research & therapy 2022 Jul 18;13(1):326
Stem cell research & therapy 2022 Jul 18;13(1):326
HDAC inhibitor quisinostat prevents estrogen deficiency-induced bone loss by suppressing bone resorption and promoting bone formation in mice.
Sun S, Xiu C, Chai L, Chen X, Zhang L, Liu Q, Chen J, Zhou H
European journal of pharmacology 2022 Jul 15;927:175073
European journal of pharmacology 2022 Jul 15;927:175073
CCL20/CCR6 axis mediates macrophages to promote proliferation and migration of ESCs by blocking autophagic flux in endometriosis.
Tan J, Xu T, Gou Y, Wang H, Liang Z, Cao Y, Wang H, Yu Y, Jiao N, Zhang Z
Stem cell research & therapy 2022 Jul 15;13(1):294
Stem cell research & therapy 2022 Jul 15;13(1):294
NRF2 Serves a Critical Role in Regulation of Immune Checkpoint Proteins (ICPs) During Trophoblast Differentiation.
Hong K, Muralimanoharan S, Kwak YT, Mendelson CR
Endocrinology 2022 Jul 1;163(7)
Endocrinology 2022 Jul 1;163(7)
Effects of bamboo leaf extract intervention on the growth performance, antioxidant capacity, and hepatic apoptosis in suckling piglets.
Yu G, Ji S, Yun Y, Cheng K, Zhang H, Jia P, Wang T, Zhang L
Journal of animal science 2022 Jul 1;100(7)
Journal of animal science 2022 Jul 1;100(7)
miR‑30a‑5p induces the adipogenic differentiation of bone marrow mesenchymal stem cells by targeting FAM13A/Wnt/β‑catenin signaling in aplastic anemia.
Wang E, Zhang Y, Ding R, Wang X, Zhang S, Li X
Molecular medicine reports 2022 Jan;25(1)
Molecular medicine reports 2022 Jan;25(1)
Shoc2 recognizes bacterial flagellin and mediates antibacterial Erk/Stat signaling in an invertebrate.
Zhao BR, Wang XX, Wang XW
PLoS pathogens 2022 Jan;18(1):e1010253
PLoS pathogens 2022 Jan;18(1):e1010253
Cyclic helix B peptide promotes random-pattern skin flap survival via TFE3-mediated enhancement of autophagy and reduction of ROS levels.
Lou J, Zhang H, Qi J, Xu Y, Wang X, Jiang J, Hu X, Ni L, Cai Y, Wang X, Gao W, Xiao J, Zhou K
British journal of pharmacology 2022 Jan;179(2):301-321
British journal of pharmacology 2022 Jan;179(2):301-321
Wilforlide A ameliorates the progression of rheumatoid arthritis by inhibiting M1 macrophage polarization.
Cao Y, Liu J, Huang C, Tao Y, Wang Y, Chen X, Huang D
Journal of pharmacological sciences 2022 Jan;148(1):116-124
Journal of pharmacological sciences 2022 Jan;148(1):116-124
Irisin lowers blood pressure in Zucker diabetic rats by regulating the functions of renal angiotensin II type 1 receptor via the inhibition of the NF-κB signaling pathway.
Huang Y, Chen Q, Jiang Q, Zhao Z, Fang J, Chen L
Peptides 2022 Jan;147:170688
Peptides 2022 Jan;147:170688
Nuclear accumulation of KPNA2 impacts radioresistance through positive regulation of the PLSCR1-STAT1 loop in lung adenocarcinoma.
Liao WC, Lin TJ, Liu YC, Wei YS, Chen GY, Feng HP, Chang YF, Chang HT, Wang CL, Chi HC, Wang CI, Lin KH, Ou Yang WT, Yu CJ
Cancer science 2022 Jan;113(1):205-220
Cancer science 2022 Jan;113(1):205-220
Extracellular vesicle-mediated delivery of circDYM alleviates CUS-induced depressive-like behaviours.
Yu X, Bai Y, Han B, Ju M, Tang T, Shen L, Li M, Yang L, Zhang Z, Hu G, Chao J, Zhang Y, Yao H
Journal of extracellular vesicles 2022 Jan;11(1):e12185
Journal of extracellular vesicles 2022 Jan;11(1):e12185
Extent and Instability of Trimethylation of Histone H3 Lysine Increases With Degree of Malignancy and Methionine Addiction.
Yamamoto J, Aoki Y, Inubushi S, Han Q, Hamada K, Tashiro Y, Miyake K, Matsuyama R, Bouvet M, Clarke SG, Endo I, Hoffman RM
Cancer genomics & proteomics 2022 Jan-Feb;19(1):12-18
Cancer genomics & proteomics 2022 Jan-Feb;19(1):12-18
Immobilized Titanium (IV) Ion Affinity Chromatography Contributes to Efficient Proteomics Analysis of Cellular Nucleic Acid-Binding Proteins.
Wang H, Qian L, Shang Z, Wang Z, Zhang Y, Cao C, Xiao H
Journal of proteome research 2022 Jan 7;21(1):220-231
Journal of proteome research 2022 Jan 7;21(1):220-231
ERK/p38/ROS burst responses to environmentally relevant concentrations of diphenyl phosphate-evoked neutrophil extracellular traps formation: Assessing the role of autophagy.
Li S, Ma Y, Ye S, Hu D, Xiao F
Journal of hazardous materials 2022 Jan 5;421:126758
Journal of hazardous materials 2022 Jan 5;421:126758
Bclaf1 regulates c-FLIP expression and protects cells from TNF-induced apoptosis and tissue injury.
Zhang R, Xue T, Shao A, Lang Y, Qin C, Zhao M, Kuang Y, Yu Z, Geng Y, Zhao C, Tang J
EMBO reports 2022 Jan 5;23(1):e52702
EMBO reports 2022 Jan 5;23(1):e52702
Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.
Zhou GQ, Chen G, Yang J, Qin WY, Ping J
Journal of ethnopharmacology 2022 Jan 30;283:114707
Journal of ethnopharmacology 2022 Jan 30;283:114707
Nrf2 loss of function exacerbates endoplasmic reticulum stress-induced apoptosis in TBI mice.
Sun G, Zhao Z, Lang J, Sun B, Zhao Q
Neuroscience letters 2022 Jan 23;770:136400
Neuroscience letters 2022 Jan 23;770:136400
SETDB1 Regulates Porcine Spermatogonial Adhesion and Proliferation through Modulating MMP3/10 Transcription.
Liu R, Liu Z, Guo M, Zeng W, Zheng Y
Cells 2022 Jan 22;11(3)
Cells 2022 Jan 22;11(3)
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
Li W, Huang BS, Xiong YY, Yang LJ, Wu LX
Cancer cell international 2022 Jan 18;22(1):32
Cancer cell international 2022 Jan 18;22(1):32
Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN.
Ji R, Jia FY, Chen X, Wang ZH, Jin WY, Yang J
Archives of biochemistry and biophysics 2022 Jan 15;715:109094
Archives of biochemistry and biophysics 2022 Jan 15;715:109094
FSH inhibits autophagy and lysosomal biogenesis to regulate protein degradation in cultured goat Sertoli cells.
Xi H, Ren F, Li Y, Xian M, Wang L, Hu J
Molecular and cellular endocrinology 2022 Jan 15;540:111505
Molecular and cellular endocrinology 2022 Jan 15;540:111505
Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation.
Xie Z, Hou L, Shen S, Wu Y, Wang J, Jie Z, Zhao X, Li X, Zhang X, Chen J, Xu W, Ning L, Ma Q, Wang S, Wang H, Yuan P, Fang X, Qin A, Fan S
Nature communications 2022 Jan 10;13(1):50
Nature communications 2022 Jan 10;13(1):50
SPOCK1 promotes metastasis in pancreatic cancer via NF-κB-dependent epithelial-mesenchymal transition by interacting with IκB-α.
Cui X, Wang Y, Lan W, Wang S, Cui Y, Zhang X, Lin Z, Piao J
Cellular oncology (Dordrecht, Netherlands) 2022 Feb;45(1):69-84
Cellular oncology (Dordrecht, Netherlands) 2022 Feb;45(1):69-84
The role of junctional adhesion molecule-C in trophoblast differentiation and function during normal pregnancy and preeclampsia.
Cao C, Dai Y, Wang Z, Zhao G, Duan H, Zhu X, Wang J, Zheng M, Weng Q, Wang L, Gou W, Zhang H, Li C, Liu D, Hu Y
Placenta 2022 Feb;118:55-65
Placenta 2022 Feb;118:55-65
Copper (Cu) induced changes of lipid metabolism through oxidative stress-mediated autophagy and Nrf2/PPARγ pathways.
Zhong CC, Zhao T, Hogstrand C, Chen F, Song CC, Luo Z
The Journal of nutritional biochemistry 2022 Feb;100:108883
The Journal of nutritional biochemistry 2022 Feb;100:108883
Toddalolactone protects against osteoarthritis by ameliorating chondrocyte inflammation and suppressing osteoclastogenesis.
Xu Y, Xue S, Zhang T, Jin X, Wang C, Lu H, Zhong Y, Chen H, Zhu L, Ma J, Sang W
Chinese medicine 2022 Feb 5;17(1):18
Chinese medicine 2022 Feb 5;17(1):18
TJ-M2010-5, A self-developed MyD88 inhibitor, attenuates liver fibrosis by inhibiting the NF-κB pathway.
Xie Y, Du D, Zhang L, Yang Y, Zou Z, Li Z, Zhou L, Shang R, Zhou P
Chemico-biological interactions 2022 Feb 25;354:109839
Chemico-biological interactions 2022 Feb 25;354:109839
The HDAC inhibitor GCJ-490A suppresses c-Met expression through IKKα and overcomes gefitinib resistance in non-small cell lung cancer.
He T, Gao Y, Fang Y, Zhang Y, Zhang S, Nan F, Ding J, Chen Y
Cancer biology & medicine 2022 Feb 22;19(8):1172-92
Cancer biology & medicine 2022 Feb 22;19(8):1172-92
Blocking iASPP/Nrf2/M-CSF axis improves anti-cancer effect of chemotherapy-induced senescence by attenuating M2 polarization.
Liu H, Zhao D, Li H, Zhang W, Lin Q, Wang X, Zheng S, Zhang L, Li L, Hu S, Hu Y
Cell death & disease 2022 Feb 21;13(2):166
Cell death & disease 2022 Feb 21;13(2):166
Acquired temozolomide resistance in MGMT(low) gliomas is associated with regulation of homologous recombination repair by ROCK2.
Zhang X, Li T, Yang M, Du Q, Wang R, Fu B, Tan Y, Cao M, Chen Y, Wang Q, Hu R
Cell death & disease 2022 Feb 10;13(2):138
Cell death & disease 2022 Feb 10;13(2):138
Dietary Selenium Alleviated Mouse Liver Oxidative Stress and NAFLD Induced by Obesity by Regulating the KEAP1/NRF2 Pathway.
Wang Y, Liu B, Wu P, Chu Y, Gui S, Zheng Y, Chen X
Antioxidants (Basel, Switzerland) 2022 Feb 10;11(2)
Antioxidants (Basel, Switzerland) 2022 Feb 10;11(2)
Liquidambaric acid inhibits Wnt/β-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2.
Yan R, Zhu H, Huang P, Yang M, Shen M, Pan Y, Zhang C, Zhou X, Li H, Ke X, Zhang W, Hao P, Qu Y
Cell reports 2022 Feb 1;38(5):110319
Cell reports 2022 Feb 1;38(5):110319
Blockade of Nuclear β-Catenin Signaling via Direct Targeting of RanBP3 with NU2058 Induces Cell Senescence to Suppress Colorectal Tumorigenesis.
Zheng CC, Liao L, Liu YP, Yang YM, He Y, Zhang GG, Li SJ, Liu T, Xu WW, Li B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Dec;9(34):e2202528
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Dec;9(34):e2202528
Kynurenine/Aryl Hydrocarbon Receptor Modulates Mitochondria-Mediated Oxidative Stress and Neuronal Apoptosis in Experimental Intracerebral Hemorrhage.
Ren R, Fang Y, Sherchan P, Lu Q, Lenahan C, Zhang JH, Zhang J, Tang J
Antioxidants & redox signaling 2022 Dec;37(16-18):1111-1129
Antioxidants & redox signaling 2022 Dec;37(16-18):1111-1129
Combined HASPIN and mTOR inhibition is synergistic against KRAS-driven carcinomas.
Xu C, Gao Q, Wu Z, Lou W, Li X, Wang M, Wang N, Li Q
Translational oncology 2022 Dec;26:101540
Translational oncology 2022 Dec;26:101540
Regulation of host factor γ-H2AX level and location by enterovirus A71 for viral replication.
Yu J, Zhang W, Huo W, Meng X, Zhong T, Su Y, Liu Y, Liu J, Wang Z, Song F, Zhang S, Li Z, Yu X, Yu X, Hua S
Virulence 2022 Dec;13(1):241-257
Virulence 2022 Dec;13(1):241-257
D-Mannose ameliorates DNCB-induced atopic dermatitis in mice and TNF-α-induced inflammation in human keratinocytes via mTOR/NF-κB pathway.
Luo J, Li Y, Zhai Y, Liu Y, Zeng J, Wang D, Li L, Zhu Z, Chang B, Deng F, Zhang J, Zhou J, Sun L
International immunopharmacology 2022 Dec;113(Pt A):109378
International immunopharmacology 2022 Dec;113(Pt A):109378
Gut dysbacteriosis attenuates resistance to Mycobacterium bovis infection by decreasing cyclooxygenase 2 to inhibit endoplasmic reticulum stress.
Wang H, Yao J, Chen Y, Wang Y, Liu Y, Liao Y, Liang Z, Dong YH, Qu M, Ge X, Zhou X
Emerging microbes & infections 2022 Dec;11(1):1806-1818
Emerging microbes & infections 2022 Dec;11(1):1806-1818
The A-to-I editing of KPC1 promotes intrahepatic cholangiocarcinoma by attenuating proteasomal processing of NF-κB1 p105 to p50.
Gao C, Zhou G, Shi J, Shi P, Jin L, Li Y, Wang X, Liao S, Yan H, Wu J, Lu Y, Zhai Y, Zhang J, Zhang H, Zhang H, Yang C, Cao P, Cheng S, Zhou G
Journal of experimental & clinical cancer research : CR 2022 Dec 8;41(1):338
Journal of experimental & clinical cancer research : CR 2022 Dec 8;41(1):338
The RNA polymerase of cytoplasmically replicating Zika virus binds with chromatin DNA in nuclei and regulates host gene transcription.
Li P, Wu J, Liu S, Lu R, Jiang H, Wang N, Luo M, Guo L, Xiao J, Bu L, Liu L, Xing F, Peng H, Li C, Ma L, Zhao B, Zhou Z, Guo D
Proceedings of the National Academy of Sciences of the United States of America 2022 Dec 6;119(49):e2205013119
Proceedings of the National Academy of Sciences of the United States of America 2022 Dec 6;119(49):e2205013119
Nucleophagic Degradation of Progerin Ameliorates Defenestration in Liver Sinusoidal Endothelium Due to SIRT1-Mediated Deacetylation of Nuclear LC3.
Bai Y, Liu J, Jiang X, Li X, Zhang B, Luo X
Cells 2022 Dec 3;11(23)
Cells 2022 Dec 3;11(23)
RNF31 represses cell progression and immune evasion via YAP/PD-L1 suppression in triple negative breast Cancer.
Yang H, Xue M, Su P, Zhou Y, Li X, Li Z, Xia Y, Zhang C, Fu M, Zheng X, Luo G, Wei T, Wang X, Ding Y, Zhu J, Zhuang T
Journal of experimental & clinical cancer research : CR 2022 Dec 29;41(1):364
Journal of experimental & clinical cancer research : CR 2022 Dec 29;41(1):364
MALAT1 modulates alternative splicing by cooperating with the splicing factors PTBP1 and PSF.
Miao H, Wu F, Li Y, Qin C, Zhao Y, Xie M, Dai H, Yao H, Cai H, Wang Q, Song X, Li L
Science advances 2022 Dec 23;8(51):eabq7289
Science advances 2022 Dec 23;8(51):eabq7289
Deficiency of CFB attenuates renal tubulointerstitial damage by inhibiting ceramide synthesis in diabetic kidney disease.
Sun ZJ, Chang DY, Chen M, Zhao MH
JCI insight 2022 Dec 22;7(24)
JCI insight 2022 Dec 22;7(24)
Proteomic Comparison of Three Wild-Type Pseudorabies Virus Strains and the Attenuated Bartha Strain Reveals Reduced Incorporation of Several Tegument Proteins in Bartha Virions.
Delva JL, Daled S, Van Waesberghe C, Almey R, Jansens RJJ, Deforce D, Dhaenens M, Favoreel HW
Journal of virology 2022 Dec 21;96(24):e0115822
Journal of virology 2022 Dec 21;96(24):e0115822
Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Targeting the Gut Microbiota Accompanied by the TLR4/NF-κB/NLRP3 Cascade Response In Vivo.
Xia X, Lin H, Luo F, Wu X, Zhu L, Chen S, Luo H, Ye F, Peng X, Zhang Y, Yang G, Lin Q
Journal of agricultural and food chemistry 2022 Dec 21;70(50):15747-15762
Journal of agricultural and food chemistry 2022 Dec 21;70(50):15747-15762
Verteporfin inhibits the dedifferentiation of tubular epithelial cells via TGF-β1/Smad pathway but induces podocyte loss in diabetic nephropathy.
Qi C, Hu Y, Zeng M, Chen H, Shi J, Jue H, Zhao Z, Liu J, Zhang Z, Xu Y, Wu H
Life sciences 2022 Dec 15;311(Pt B):121186
Life sciences 2022 Dec 15;311(Pt B):121186
Melatonin attenuates bone cancer pain via the SIRT1/HMGB1 pathway.
Yang C, Kang F, Huang X, Zhang W, Wang S, Han M, Zhang Z, Li J
Neuropharmacology 2022 Dec 1;220:109254
Neuropharmacology 2022 Dec 1;220:109254
circNup188/miR-760-3p/Map3k8 axis regulates inflammation in cerebral ischemia.
Zhang H, Deng J, Huang K, He Y, Cai Z, He Y
Molecular and cellular probes 2022 Aug;64:101830
Molecular and cellular probes 2022 Aug;64:101830
MgIG exerts therapeutic effects on crizotinib-induced hepatotoxicity by limiting ROS-mediated autophagy and pyroptosis.
Li M, Wang C, Yu Z, Lan Q, Xu S, Ye Z, Li R, Ying L, Zhang X, Zhou Z
Journal of cellular and molecular medicine 2022 Aug;26(16):4492-4505
Journal of cellular and molecular medicine 2022 Aug;26(16):4492-4505
GPR108 is required for gambogic acid inhibiting NF-κB signaling in cancer.
Lyu S, Zhang X, Tu Z, Zhou H, Ke X, Qu Y
Pharmacological research 2022 Aug;182:106279
Pharmacological research 2022 Aug;182:106279
KSHV RTA antagonizes SMC5/6 complex-induced viral chromatin compaction by hijacking the ubiquitin-proteasome system.
Han C, Zhang D, Gui C, Huang L, Chang S, Dong L, Bai L, Wu S, Lan K
PLoS pathogens 2022 Aug;18(8):e1010744
PLoS pathogens 2022 Aug;18(8):e1010744
Potential dual protective effects of melatonin on spermatogonia against hexavalent chromium.
Li T, Zheng Y, Li T, Guo M, Wu X, Liu R, Liu Q, You X, Zeng W, Lv Y
Reproductive toxicology (Elmsford, N.Y.) 2022 Aug;111:92-105
Reproductive toxicology (Elmsford, N.Y.) 2022 Aug;111:92-105
RP105 protects against ischemic and septic acute kidney injury via suppressing TLR4/NF-κB signaling pathways.
Zhu J, Zhang Y, Shi L, Xia Y, Zha H, Li H, Song Z
International immunopharmacology 2022 Aug;109:108904
International immunopharmacology 2022 Aug;109:108904
Global phosphoproteomic analysis identified key kinases regulating male meiosis in mouse.
Li H, Chen H, Zhang X, Qi Y, Wang B, Cui Y, Ren J, Zhao Y, Chen Y, Zhu T, Wang Y, Yao L, Guo Y, Zhu H, Li Y, Situ C, Guo X
Cellular and molecular life sciences : CMLS 2022 Aug 5;79(8):467
Cellular and molecular life sciences : CMLS 2022 Aug 5;79(8):467
MicroRNA-363-3p/sphingosine-1-phosphate receptor 1 axis inhibits sepsis-induced acute lung injury via the inactivation of nuclear factor kappa-B ligand signaling.
Meng S, Kang K, Fei D, Yang S, Pan S, Yu K, Zhao M
Experimental animals 2022 Aug 5;71(3):305-315
Experimental animals 2022 Aug 5;71(3):305-315
Motoneurons innervation determines the distinct gene expressions in multinucleated myofibers.
Bai L, Tu WY, Xiao Y, Zhang K, Shen C
Cell & bioscience 2022 Aug 30;12(1):140
Cell & bioscience 2022 Aug 30;12(1):140
Cornuside Is a Potential Agent against Alzheimer's Disease via Orchestration of Reactive Astrocytes.
Shi JZ, Zheng XM, Zhou YF, Yun LY, Luo DM, Hao JJ, Liu PF, Zhang WK, Xu JK, Yan Y, Xie XM, He YY, Pang XB
Nutrients 2022 Aug 3;14(15)
Nutrients 2022 Aug 3;14(15)
Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer's disease.
Dong Y, Yu H, Li X, Bian K, Zheng Y, Dai M, Feng X, Sun Y, He Y, Yu B, Zhang H, Wu J, Yu X, Wu H, Kong W
Journal of neuroinflammation 2022 Aug 15;19(1):205
Journal of neuroinflammation 2022 Aug 15;19(1):205
Protective Effect of Cardiomyocyte-Specific Prolyl-4-Hydroxylase 2 Inhibition on Ischemic Injury in a Mouse MI Model.
Pradeep SR, Lim ST, Thirunavukkarasu M, Joshi M, Cernuda B, Palesty JA, Maulik N
Journal of the American College of Surgeons 2022 Aug 1;235(2):240-254
Journal of the American College of Surgeons 2022 Aug 1;235(2):240-254
Flavonoid 4,4'-dimethoxychalcone induced ferroptosis in cancer cells by synergistically activating Keap1/Nrf2/HMOX1 pathway and inhibiting FECH.
Yang C, Wang T, Zhao Y, Meng X, Ding W, Wang Q, Liu C, Deng H
Free radical biology & medicine 2022 Aug 1;188:14-23
Free radical biology & medicine 2022 Aug 1;188:14-23
MiR-200c-3p inhibits LPS-induced M1 polarization of BV2 cells by targeting RIP2.
Zhao L, Liu X, Yang J, Wang X, Liu X, Wu J, Li C, Xu D, Hu Y
Genes & genomics 2022 Apr;44(4):477-486
Genes & genomics 2022 Apr;44(4):477-486
HDAC3 inhibition improves urinary-concentrating defect in hypokalaemia by promoting AQP2 transcription.
Xu L, Xie H, Hu S, Zhao X, Han M, Liu Q, Feng P, Wang W, Li C
Acta physiologica (Oxford, England) 2022 Apr;234(4):e13802
Acta physiologica (Oxford, England) 2022 Apr;234(4):e13802
Tumor-promoting mechanisms of macrophage-derived extracellular vesicles-enclosed microRNA-660 in breast cancer progression.
Li C, Li R, Hu X, Zhou G, Jiang G
Breast cancer research and treatment 2022 Apr;192(2):353-368
Breast cancer research and treatment 2022 Apr;192(2):353-368
Hepatoprotective Effects of Albumin-Encapsulated Nanoparticles of a Curcumin Derivative COP-22 against Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Injury in Mice.
Mu W, Wang Q, Jia M, Dong S, Li S, Yang J, Liu G
International journal of molecular sciences 2022 Apr 28;23(9)
International journal of molecular sciences 2022 Apr 28;23(9)
Linkage of methionine addiction, histone lysine hypermethylation, and malignancy.
Yamamoto J, Inubushi S, Han Q, Tashiro Y, Sugisawa N, Hamada K, Aoki Y, Miyake K, Matsuyama R, Bouvet M, Clarke SG, Endo I, Hoffman RM
iScience 2022 Apr 15;25(4):104162
iScience 2022 Apr 15;25(4):104162
Mitochondrial Proteins Unveil the Mechanism by Which Physical Exercise Ameliorates Memory, Learning and Motor Activity in Hypoxic Ischemic Encephalopathy Rat Model.
Gendi F, Pei F, Wang Y, Li H, Fu J, Chang C
International journal of molecular sciences 2022 Apr 11;23(8)
International journal of molecular sciences 2022 Apr 11;23(8)
Histone chaperone HIRA complex regulates retrotransposons in embryonic stem cells.
Zhang M, Zhao X, Feng X, Hu X, Zhao X, Lu W, Lu X
Stem cell research & therapy 2022 Apr 1;13(1):137
Stem cell research & therapy 2022 Apr 1;13(1):137
GLIS Family Zinc Finger 1 was First Linked With Preaxial Polydactyly I in Humans by Stepwise Genetic Analysis.
Jin JY, Wu PF, Luo FM, Guo BB, Zeng L, Fan LL, Tang JY, Xiang R
Frontiers in cell and developmental biology 2021;9:781388
Frontiers in cell and developmental biology 2021;9:781388
NAP1L5 Promotes Nucleolar Hypertrophy and Is Required for Translation Activation During Cardiomyocyte Hypertrophy.
Guo N, Zheng D, Sun J, Lv J, Wang S, Fang Y, Zhao Z, Zeng S, Guo Q, Tong J, Wang Z
Frontiers in cardiovascular medicine 2021;8:791501
Frontiers in cardiovascular medicine 2021;8:791501
GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation.
Xu Y, Hu X, Li F, Zhang H, Lou J, Wang X, Wang H, Yin L, Ni W, Kong J, Wang X, Li Y, Zhou K, Xu H
Oxidative medicine and cellular longevity 2021;2021:8186877
Oxidative medicine and cellular longevity 2021;2021:8186877
Tanshinone I Mitigates Steroid-Induced Osteonecrosis of the Femoral Head and Activates the Nrf2 Signaling Pathway in Rats.
Xu X, Shen Y, Lv H, Zhao J, Li X, Gao L, Ren S, Zhang X
Evidence-based complementary and alternative medicine : eCAM 2021;2021:8002161
Evidence-based complementary and alternative medicine : eCAM 2021;2021:8002161
Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo.
Lu S, Song Y, Luo R, Li S, Li G, Wang K, Liao Z, Wang B, Ke W, Xiang Q, Chen C, Wu X, Zhang Y, Ling L, Yang C
Oxidative medicine and cellular longevity 2021;2021:6670497
Oxidative medicine and cellular longevity 2021;2021:6670497
Attenuated lncRNA NKILA Enhances the Secretory Function of Airway Epithelial Cells Stimulated by Mycoplasma pneumoniae via NF-κB.
Zhang F, Zhang J, Liu F, Zhou Y, Guo Y, Duan Q, Zhu Y, Zhao D, Gu H
BioMed research international 2021;2021:6656298
BioMed research international 2021;2021:6656298
Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.
Zhu X, Hu X, Lou J, Li J, Xu Y, Yu G, Wu C, Ding J, Gao W, Xiao J, Zhou K, Jia C
Oxidative medicine and cellular longevity 2021;2021:6610603
Oxidative medicine and cellular longevity 2021;2021:6610603
Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway.
Lin Y, Xie Y, Hao Z, Bi H, Liu Y, Yang X, Xia Y
Journal of immunology research 2021;2021:5151168
Journal of immunology research 2021;2021:5151168
miRNA-27a Transcription Activated by c-Fos Regulates Myocardial Ischemia-Reperfusion Injury by Targeting ATAD3a.
Bao Y, Qiao Y, Yu H, Zhang Z, Yang H, Xin X, Chen Y, Guo Y, Wu N, Jia D
Oxidative medicine and cellular longevity 2021;2021:2514947
Oxidative medicine and cellular longevity 2021;2021:2514947
Buyang Huanwu Decoction Enhances Revascularization via Akt/GSK3β/NRF2 Pathway in Diabetic Hindlimb Ischemia.
Bao XY, Deng LH, Huang ZJ, Daror AS, Wang ZH, Jin WJ, Zhuang Z, Tong Q, Zheng GQ, Wang Y
Oxidative medicine and cellular longevity 2021;2021:1470829
Oxidative medicine and cellular longevity 2021;2021:1470829
Identification of Histone Modifications Reveals a Role of H2b Monoubiquitination in Transcriptional Regulation of dmrt1 in Monopterus albus.
Lai F, Cheng Y, Zou J, Wang H, Zhu W, Wang X, Cheng H, Zhou R
International journal of biological sciences 2021;17(8):2009-2020
International journal of biological sciences 2021;17(8):2009-2020
GABAB receptor inhibits tumor progression and epithelial-mesenchymal transition via the regulation of Hippo/YAP1 pathway in colorectal cancer.
Wang H, Zhang H, Sun Z, Chen W, Miao C
International journal of biological sciences 2021;17(8):1953-1962
International journal of biological sciences 2021;17(8):1953-1962
ITGB1 enhances the Radioresistance of human Non-small Cell Lung Cancer Cells by modulating the DNA damage response and YAP1-induced Epithelial-mesenchymal Transition.
Li Y, Sun C, Tan Y, Zhang H, Li Y, Zou H
International journal of biological sciences 2021;17(2):635-650
International journal of biological sciences 2021;17(2):635-650
Discovery of a novel HDACi structure that inhibits the proliferation of ovarian cancer cells in vivo and in vitro.
Bai M, Cui M, Li M, Yao X, Wu Y, Zheng L, Sun L, Song Q, Wang S, Liu L, Yu C, Huang Y
International journal of biological sciences 2021;17(13):3493-3507
International journal of biological sciences 2021;17(13):3493-3507
Psychostimulants and opioids differentially influence the epigenetic modification of histone acetyltransferase and histone deacetylase in astrocytes.
Doke M, Pendyala G, Samikkannu T
PloS one 2021;16(6):e0252895
PloS one 2021;16(6):e0252895
ADAM17 and NF-κB p65 form a positive feedback loop that facilitates human esophageal squamous cell carcinoma cell viability.
Gao L, Liu H, Xu R, Qiu J, Peng X, Yang Y, Zhang D, Qian J
International journal of clinical and experimental pathology 2021;14(7):845-854
International journal of clinical and experimental pathology 2021;14(7):845-854
Lovastatin Alleviates α-Synuclein Aggregation and Phosphorylation in Cellular Models of Synucleinopathy.
Dai L, Wang J, He M, Xiong M, Tian Y, Liu C, Zhang Z
Frontiers in molecular neuroscience 2021;14:682320
Frontiers in molecular neuroscience 2021;14:682320
Clock Gene Nr1d1 Alleviates Retinal Inflammation Through Repression of Hmga2 in Microglia.
Wang Z, Huang Y, Chu F, Ji S, Liao K, Cui Z, Chen J, Tang S
Journal of inflammation research 2021;14:5901-5918
Journal of inflammation research 2021;14:5901-5918
Ulinastatin protects against acetaminophen-induced liver injury by alleviating ferroptosis via the SIRT1/NRF2/HO-1 pathway.
Wang C, Liu T, Tong Y, Cui R, Qu K, Liu C, Zhang J
American journal of translational research 2021;13(6):6031-6042
American journal of translational research 2021;13(6):6031-6042
Calcitriol Alleviates MPP(+)- and MPTP-Induced Parthanatos Through the VDR/PARP1 Pathway in the Model of Parkinson's Disease.
Hu J, Wu J, Wan F, Kou L, Yin S, Sun Y, Li Y, Zhou Q, Wang T
Frontiers in aging neuroscience 2021;13:657095
Frontiers in aging neuroscience 2021;13:657095
Shenkang Injection and Its Three Anthraquinones Ameliorates Renal Fibrosis by Simultaneous Targeting IƙB/NF-ƙB and Keap1/Nrf2 Signaling Pathways.
Luo LP, Suo P, Ren LL, Liu HJ, Zhang Y, Zhao YY
Frontiers in pharmacology 2021;12:800522
Frontiers in pharmacology 2021;12:800522
Chinese Herbal Preparation SaiLuoTong Alleviates Brain Ischemia via Nrf2 Antioxidation Pathway-Dependent Cerebral Microvascular Protection.
Fan XD, Yao MJ, Yang B, Han X, Zhang YH, Wang GR, Li P, Xu L, Liu JX
Frontiers in pharmacology 2021;12:748568
Frontiers in pharmacology 2021;12:748568
TAS2R16 Activation Suppresses LPS-Induced Cytokine Expression in Human Gingival Fibroblasts.
Zhou Z, Xi R, Liu J, Peng X, Zhao L, Zhou X, Li J, Zheng X, Xu X
Frontiers in immunology 2021;12:726546
Frontiers in immunology 2021;12:726546
Neutrophil Extracellular Traps Caused by Gut Leakage Trigger the Autoimmune Response in Nonobese Diabetic Mice.
You Q, Shen Y, Wu Y, Li Y, Liu C, Huang F, Gu HF, Wu J
Frontiers in immunology 2021;12:711423
Frontiers in immunology 2021;12:711423
Ras-Related C3 Botulinum Toxin Substrate 1 Combining With the Mixed Lineage Kinase 3- Mitogen-Activated Protein Kinase 7- c-Jun N-Terminal Kinase Signaling Module Accelerates Diabetic Nephropathy.
Ying C, Dai J, Fan G, Zhou Z, Gan T, Zhang Y, Song Y, Zhou X
Frontiers in physiology 2021;12:679166
Frontiers in physiology 2021;12:679166
Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.
Zheng T, Yang J, Zhang J, Yang C, Fan Z, Li Q, Zhai Y, Liu H, Yang J
Frontiers in pharmacology 2021;12:669146
Frontiers in pharmacology 2021;12:669146
Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway.
Zhou F, Zhang X, Jiang L, Li S, Chen Y, Wu J
Frontiers in pharmacology 2021;12:667524
Frontiers in pharmacology 2021;12:667524
Propofol Inhibits Ischemia/Reperfusion-Induced Cardiotoxicity Through the Protein Kinase C/Nuclear Factor Erythroid 2-Related Factor Pathway.
Li S, Lei Z, Zhao M, Hou Y, Wang D, Xu X, Lin X, Li J, Tang S, Yu J, Meng T
Frontiers in pharmacology 2021;12:655726
Frontiers in pharmacology 2021;12:655726
Dietary Inorganic Nitrate Protects Hepatic Ischemia-Reperfusion Injury Through NRF2-Mediated Antioxidative Stress.
Li S, Jin H, Sun G, Zhang C, Wang J, Xu H, Zhang D, Wang S
Frontiers in pharmacology 2021;12:634115
Frontiers in pharmacology 2021;12:634115
Proteomic analysis of lung cancer cells reveals a critical role of BCAT1 in cancer cell metastasis.
Mao L, Chen J, Lu X, Yang C, Ding Y, Wang M, Zhang Y, Tian Y, Li X, Fu Y, Yang Y, Gu Y, Gao F, Huang J, Liao L
Theranostics 2021;11(19):9705-9720
Theranostics 2021;11(19):9705-9720
Phenethyl Isothiocyanate Enhances the Cytotoxic Effects of PARP Inhibitors in High-Grade Serous Ovarian Cancer Cells.
Jia Y, Wang M, Sang X, Liu P, Gao J, Jiang K, Cheng H
Frontiers in oncology 2021;11:812264
Frontiers in oncology 2021;11:812264
Nox2 impairs VEGF-A-induced angiogenesis in placenta via mitochondrial ROS-STAT3 pathway.
Hu C, Wu Z, Huang Z, Hao X, Wang S, Deng J, Yin Y, Tan C
Redox biology 2021 Sep;45:102051
Redox biology 2021 Sep;45:102051
The scaffold protein IQGAP1 links heat-induced stress signals to alternative splicing regulation in gastric cancer cells.
Birladeanu AM, Rogalska M, Potiri M, Papadaki V, Andreadou M, Kontoyiannis DL, Lewis JD, Erpapazoglou Z, Kafasla P
Oncogene 2021 Sep;40(36):5518-5532
Oncogene 2021 Sep;40(36):5518-5532
Exogenous H(2) S prevents the nuclear translocation of PDC-E1 and inhibits vascular smooth muscle cell proliferation in the diabetic state.
Zhang L, Jiang X, Liu N, Li M, Kang J, Chen L, Tang J, Dong S, Lu F, Zhang W
Journal of cellular and molecular medicine 2021 Sep;25(17):8201-8214
Journal of cellular and molecular medicine 2021 Sep;25(17):8201-8214
OGT regulated O-GlcNacylation promotes migration and invasion by activating IL-6/STAT3 signaling in NSCLC cells.
Ge X, Peng X, Li M, Ji F, Chen J, Zhang D
Pathology, research and practice 2021 Sep;225:153580
Pathology, research and practice 2021 Sep;225:153580
Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca(2+)](m)-PDP1-PDH-histone acetylation retrograde signaling.
Shi Y, Wang Y, Jiang H, Sun X, Xu H, Wei X, Wei Y, Xiao G, Song Z, Zhou F
Cell death & disease 2021 Sep 6;12(9):837
Cell death & disease 2021 Sep 6;12(9):837
Interferon functional analog activates antiviral Jak/Stat signaling through integrin in an arthropod.
Gao J, Zhao BR, Zhang H, You YL, Li F, Wang XW
Cell reports 2021 Sep 28;36(13):109761
Cell reports 2021 Sep 28;36(13):109761
Lactobacillus johnsonii L531 Alleviates the Damage Caused by Salmonella Typhimurium via Inhibiting TLR4, NF-κB, and NLRP3 Inflammasome Signaling Pathways.
Chen S, Li Y, Chu B, Yuan L, Liu N, Zhu Y, Wang J
Microorganisms 2021 Sep 17;9(9)
Microorganisms 2021 Sep 17;9(9)
Yixin-Fumai granules improve sick sinus syndrome in aging mice through Nrf-2/HO-1 pathway: A new target for sick sinus syndrome.
Zhang H, Li L, Hao M, Chen K, Lu Y, Qi J, Chen W, Ren L, Cai X, Chen C, Liu Z, Zhao B, Li Z, Hou P
Journal of ethnopharmacology 2021 Sep 15;277:114254
Journal of ethnopharmacology 2021 Sep 15;277:114254
Lactobacillus casei relieves liver injury by regulating immunity and suppression of the enterogenic endotoxin-induced inflammatory response in rats cotreated with alcohol and iron.
Li X, Han J, Liu Y, Liang H
Food science & nutrition 2021 Oct;9(10):5391-5401
Food science & nutrition 2021 Oct;9(10):5391-5401
Activation of the Hippocampal LXRβ Improves Sleep-Deprived Cognitive Impairment by Inhibiting Neuroinflammation.
Qiu C, Wang M, Yu W, Rong Z, Zheng HS, Sun T, Liu SB, Zhao MG, Wu YM
Molecular neurobiology 2021 Oct;58(10):5272-5288
Molecular neurobiology 2021 Oct;58(10):5272-5288
Role of Intracellular Distribution of Feline and Bovine SAMHD1 Proteins in Lentiviral Restriction.
Wang C, Meng L, Wang J, Zhang K, Duan S, Ren P, Wei Y, Fu X, Yu B, Wu J, Yu X
Virologica Sinica 2021 Oct;36(5):981-996
Virologica Sinica 2021 Oct;36(5):981-996
PML Suppresses Influenza Virus Replication by Promoting FBXW7 Expression.
Yan HY, Wang HQ, Zhong M, Wu S, Yang L, Li K, Li YH
Virologica Sinica 2021 Oct;36(5):1154-1164
Virologica Sinica 2021 Oct;36(5):1154-1164
The p38 MAPK/NF-κB pathway mediates GLT-1 up-regulation during cerebral ischemic preconditioning-induced brain ischemic tolerance in rats.
Sun YW, Zhang LY, Gong SJ, Hu YY, Zhang JG, Xian XH, Li WB, Zhang M
Brain research bulletin 2021 Oct;175:224-233
Brain research bulletin 2021 Oct;175:224-233
SGLT2 promotes pancreatic cancer progression by activating the Hippo signaling pathway via the hnRNPK-YAP1 axis.
Ren D, Sun Y, Zhang D, Li D, Liu Z, Jin X, Wu H
Cancer letters 2021 Oct 28;519:277-288
Cancer letters 2021 Oct 28;519:277-288
Hsa_circ_0004296 inhibits metastasis of prostate cancer by interacting with EIF4A3 to prevent nuclear export of ETS1 mRNA.
Mao S, Zhang W, Yang F, Guo Y, Wang H, Wu Y, Wang R, Maskey N, Zheng Z, Li C, Ma W, Zhang J, Yan Y, Yao X
Journal of experimental & clinical cancer research : CR 2021 Oct 25;40(1):336
Journal of experimental & clinical cancer research : CR 2021 Oct 25;40(1):336
Hexavalent chromium inhibits the formation of neutrophil extracellular traps and promotes the apoptosis of neutrophils via AMPK signaling pathway.
Ma Y, Li S, Ye S, Tang S, Hu D, Wei L, Xiao F
Ecotoxicology and environmental safety 2021 Oct 15;223:112614
Ecotoxicology and environmental safety 2021 Oct 15;223:112614
Harpagide alleviate neuronal apoptosis and blood-brain barrier leakage by inhibiting TLR4/MyD88/NF-κB signaling pathway in Angiotensin II-induced microglial activation in vitro.
Lu Y, Hao R, Hu Y, Wei Y, Xie Y, Shen Y, Rui Q, Yu G
Chemico-biological interactions 2021 Oct 1;348:109653
Chemico-biological interactions 2021 Oct 1;348:109653
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.
Wang J, Su Q, Wu Q, Chen K, Ullah A, Ghauri MA, Zhang Y
Archives of pharmacal research 2021 Nov;44(11):1025-1036
Archives of pharmacal research 2021 Nov;44(11):1025-1036
Over-methylation of Histone H3 Lysines Is a Common Molecular Change Among the Three Major Types of Soft-tissue Sarcoma in Patient-derived Xenograft (PDX) Mouse Models.
Aoki Y, Yamamoto J, Tome Y, Hamada K, Masaki N, Inubushi S, Tashiro Y, Bouvet M, Endo I, Nishida K, Hoffman RM
Cancer genomics & proteomics 2021 Nov-Dec;18(6):715-721
Cancer genomics & proteomics 2021 Nov-Dec;18(6):715-721
Discovery of Phenolic Glycoside from Hyssopus cuspidatus Attenuates LPS-Induced Inflammatory Responses by Inhibition of iNOS and COX-2 Expression through Suppression of NF-κB Activation.
Liu X, Su J, Wang G, Zheng L, Wang G, Sun Y, Bao Y, Wang S, Huang Y
International journal of molecular sciences 2021 Nov 9;22(22)
International journal of molecular sciences 2021 Nov 9;22(22)
LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome.
Wang G, Jin S, Huang W, Li Y, Wang J, Ling X, Huang Y, Hu Y, Li C, Meng Y, Li X
Cell death discovery 2021 Nov 6;7(1):337
Cell death discovery 2021 Nov 6;7(1):337
Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo.
Liu Y, Zhou J, Luo Y, Li J, Shang L, Zhou F, Yang S
Chinese medicine 2021 Nov 29;16(1):127
Chinese medicine 2021 Nov 29;16(1):127
Establishment of an Efficient Immortalization Strategy Using HMEJ-Based bTERT Insertion for Bovine Cells.
Zhang Z, Han Z, Guo Y, Liu X, Gao Y, Zhang Y
International journal of molecular sciences 2021 Nov 21;22(22)
International journal of molecular sciences 2021 Nov 21;22(22)
Scutellarin alleviates depression-like behaviors induced by LPS in mice partially through inhibition of astrocyte-mediated neuroinflammation.
Lu L, Yang LK, Yue J, Wang XS, Qi JY, Yang F, Feng B, Liu SB
Neuroscience letters 2021 Nov 20;765:136284
Neuroscience letters 2021 Nov 20;765:136284
Kaempferide enhances antioxidant capacity to promote osteogenesis through FoxO1/β-catenin signaling pathway.
Ma X, Tian Y, Xue K, Huai Y, Patil S, Deng X, Hao Q, Li D, Miao Z, Zhang W, Qian A
European journal of pharmacology 2021 Nov 15;911:174555
European journal of pharmacology 2021 Nov 15;911:174555
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
Chen M, Sun X, Wei W, Cucarella C, Martín-Sanz P, Casado M, Pi L, Ren B, Cao Q
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
Li J, Chen H, Lou J, Bao G, Wu C, Lou Z, Wang X, Ding J, Li Z, Xiao J, Xu H, Gao W, Zhou K
Journal of cellular physiology 2021 May;236(5):3641-3659
Journal of cellular physiology 2021 May;236(5):3641-3659
BCL7C suppresses ovarian cancer growth by inactivating mutant p53.
Huang C, Hao Q, Shi G, Zhou X, Zhang Y
Journal of molecular cell biology 2021 May 7;13(2):141-150
Journal of molecular cell biology 2021 May 7;13(2):141-150
BATF Regulates T Regulatory Cell Functional Specification and Fitness of Triglyceride Metabolism in Restraining Allergic Responses.
Xu C, Fu Y, Liu S, Trittipo J, Lu X, Qi R, Du H, Yan C, Zhang C, Wan J, Kaplan MH, Yang K
Journal of immunology (Baltimore, Md. : 1950) 2021 May 1;206(9):2088-2100
Journal of immunology (Baltimore, Md. : 1950) 2021 May 1;206(9):2088-2100
Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress-induced premature senescence.
Luo X, Bai Y, He S, Sun S, Jiang X, Yang Z, Lu D, Wei P, Liang Y, Peng C, Wang Y, Sheng R, Han S, Li X, Zhang B
Cell proliferation 2021 Mar;54(3):e12991
Cell proliferation 2021 Mar;54(3):e12991
Nucleolar and spindle‑associated protein 1 promotes non‑small cell lung cancer progression and serves as an effector of myocyte enhancer factor 2D.
Ling B, Wei P, Xiao J, Cen B, Wei H, Feng X, Ye G, Li S, Zhang Z, Liang W, Huang S, Huang W
Oncology reports 2021 Mar;45(3):1044-1058
Oncology reports 2021 Mar;45(3):1044-1058
Hepatocyte growth factor overexpression promotes osteoclastogenesis and exacerbates bone loss in CIA mice.
Huang C, Zheng Y, Bai J, Shi C, Shi X, Shan H, Zhou X
Journal of orthopaedic translation 2021 Mar;27:9-16
Journal of orthopaedic translation 2021 Mar;27:9-16
Bluetongue virus non-structural protein 3 (NS3) and NS4 coordinatively antagonize type Ⅰ interferon signaling by targeting STAT1.
Li Z, Lu D, Yang H, Li Z, Zhu P, Xie J, Liao D, Zheng Y, Li H
Veterinary microbiology 2021 Mar;254:108986
Veterinary microbiology 2021 Mar;254:108986
Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy.
Zhang T, Yang X, Xu W, Wang J, Wu D, Hong Z, Yuan S, Zeng Z, Jia X, Lu S, Safadi R, Han S, Yang Z, Neckers LM, Liangpunsakul S, Zhou W, Lu Y
Cancer biology & medicine 2021 Mar 25;18(3):693-704
Cancer biology & medicine 2021 Mar 25;18(3):693-704
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
Guo H, Wang Y, Jia W, Liu L
Physiological research 2021 Mar 17;70(1):67-78
Physiological research 2021 Mar 17;70(1):67-78
Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.
Li X, Zhang J, Li D, He C, He K, Xue T, Wan L, Zhang C, Liu Q
Neuron 2021 Mar 17;109(6):957-970.e8
Neuron 2021 Mar 17;109(6):957-970.e8
New insights into Vitamin C function: Vitamin C induces JAK2 activation through its receptor-like transporter SVCT2.
Han Z, Zhang Z, Guan Y, Chen B, Yu M, Zhang L, Fang J, Gao Y, Guo Z
International journal of biological macromolecules 2021 Mar 15;173:379-398
International journal of biological macromolecules 2021 Mar 15;173:379-398
A phase-separated nuclear GBPL circuit controls immunity in plants.
Huang S, Zhu S, Kumar P, MacMicking JD
Nature 2021 Jun;594(7863):424-429
Nature 2021 Jun;594(7863):424-429
Mutual dependency between lncRNA LETN and protein NPM1 in controlling the nucleolar structure and functions sustaining cell proliferation.
Wang X, Hu X, Song W, Xu H, Xiao Z, Huang R, Bai Q, Zhang F, Chen Y, Liu Y, Fang J, Li X, Shen Q, Zhao H, Yang X
Cell research 2021 Jun;31(6):664-683
Cell research 2021 Jun;31(6):664-683
Dioscin inhibits SCC15 cell proliferation via the RASSF1A/MST2/YAP axis.
Tian H, Chen X, Zhang Y, Wang Y, Fu X, Gu W, Wen Y
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
Cellular FADD-like IL-1β-converting enzyme-inhibitory protein attenuates myocardial ischemia/reperfusion injury via suppressing apoptosis and autophagy simultaneously.
Liu D, Wu H, Li YZ, Yang J, Yang J, Ding JW, Zhou G, Zhang J, Wang X, Fan ZX
Nutrition, metabolism, and cardiovascular diseases : NMCD 2021 Jun 7;31(6):1916-1928
Nutrition, metabolism, and cardiovascular diseases : NMCD 2021 Jun 7;31(6):1916-1928
Bromodomain-containing proteins BRD1, BRD2, and BRD13 are core subunits of SWI/SNF complexes and vital for their genomic targeting in Arabidopsis.
Yu Y, Fu W, Xu J, Lei Y, Song X, Liang Z, Zhu T, Liang Y, Hao Y, Yuan L, Li C
Molecular plant 2021 Jun 7;14(6):888-904
Molecular plant 2021 Jun 7;14(6):888-904
Long noncoding RNA DGCR5 involves in tumorigenesis of esophageal squamous cell carcinoma via SRSF1-mediated alternative splicing of Mcl-1.
Duan Y, Jia Y, Wang J, Liu T, Cheng Z, Sang M, Lv W, Qin J, Liu L
Cell death & disease 2021 Jun 7;12(6):587
Cell death & disease 2021 Jun 7;12(6):587
Cisplatin remodels the tumor immune microenvironment via the transcription factor EB in ovarian cancer.
Liu W, Wang Y, Xie Y, Dai T, Fan M, Li C, Zou Y
Cell death discovery 2021 Jun 5;7(1):136
Cell death discovery 2021 Jun 5;7(1):136
Ischemic heart injury leads to HIF1-dependent differential splicing of CaMK2γ.
Williams AL, Walton CB, Pinell B, Khadka VS, Dunn B, Lee K, Anagaran MCT, Avelar A, Shohet RV
Scientific reports 2021 Jun 23;11(1):13116
Scientific reports 2021 Jun 23;11(1):13116
OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair.
Cui Y, Xie R, Zhang X, Liu Y, Hu Y, Li Y, Liu X, Yu X, Wu C
Cell death & disease 2021 Jun 16;12(7):622
Cell death & disease 2021 Jun 16;12(7):622
Resveratrol and its derivative pterostilbene ameliorate intestine injury in intrauterine growth-retarded weanling piglets by modulating redox status and gut microbiota.
Chen Y, Zhang H, Chen Y, Jia P, Ji S, Zhang Y, Wang T
Journal of animal science and biotechnology 2021 Jun 10;12(1):70
Journal of animal science and biotechnology 2021 Jun 10;12(1):70
Caspase-1 inhibits IFN-β production via cleavage of cGAS during M. bovis infection.
Liao Y, Liu C, Wang J, Song Y, Sabir N, Hussain T, Yao J, Luo L, Wang H, Cui Y, Yang L, Zhao D, Zhou X
Veterinary microbiology 2021 Jul;258:109126
Veterinary microbiology 2021 Jul;258:109126
Activation of microglial G‑protein-coupled receptor 30 protects neurons against excitotoxicity through NF-κB/MAPK pathways.
Yang LK, Lu L, Yue J, Wang XS, Qi JY, Yang F, Liu SB
Brain research bulletin 2021 Jul;172:22-30
Brain research bulletin 2021 Jul;172:22-30
Identification of small molecules that mitigate vincristine-induced neurotoxicity while sensitizing leukemia cells to vincristine.
Diouf B, Wing C, Panetta JC, Eddins D, Lin W, Yang W, Fan Y, Pei D, Cheng C, Delaney SM, Zhang W, Bonten EJ, Crews KR, Paugh SW, Li L, Freeman BB 3rd, Autry RJ, Beard JA, Ferguson DC, Janke LJ, Ness KK, Chen T, Zakharenko SS, Jeha S, Pui CH, Relling MV, Eileen Dolan M, Evans WE
Clinical and translational science 2021 Jul;14(4):1490-1504
Clinical and translational science 2021 Jul;14(4):1490-1504
PP1 regulatory subunit NIPP1 regulates transcription of E2F1 target genes following DNA damage.
Hanaki S, Habara M, Masaki T, Maeda K, Sato Y, Nakanishi M, Shimada M
Cancer science 2021 Jul;112(7):2739-2752
Cancer science 2021 Jul;112(7):2739-2752
Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson's Disease Models.
Verma DK, Seo BA, Ghosh A, Ma SX, Hernandez-Quijada K, Andersen JK, Ko HS, Kim YH
Cells 2021 Jul 5;10(7)
Cells 2021 Jul 5;10(7)
Core Histones Are Constituents of the Perinuclear Theca of Murid Spermatozoa: An Assessment of Their Synthesis and Assembly during Spermiogenesis and Function after Gametic Fusion.
Hamilton LE, Lion M, Aguila L, Suzuki J, Acteau G, Protopapas N, Xu W, Sutovsky P, Baker M, Oko R
International journal of molecular sciences 2021 Jul 29;22(15)
International journal of molecular sciences 2021 Jul 29;22(15)
HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity.
Luo W, Li J, Li Z, Lin T, Zhang L, Yang W, Mai Y, Liu R, Chen M, Dai C, Yang H, Lu J, Li H, Guan G, Huang M, Liu P, Li Z
Cell death & disease 2021 Jul 26;12(8):738
Cell death & disease 2021 Jul 26;12(8):738
Induction of mitochondrial apoptosis pathway mediated through caspase-8 and c-Jun N-terminal kinase by cadmium-activated Fas in rat cortical neurons.
Wen S, Wang L, Zhang W, Xu M, Song R, Zou H, Gu J, Bian J, Yuan Y, Liu Z
Metallomics : integrated biometal science 2021 Jul 12;13(7)
Metallomics : integrated biometal science 2021 Jul 12;13(7)
Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans.
Liu C, Liu H, Zhang H, Wang L, Li M, Cai F, Wang X, Wang L, Zhang R, Yang S, Liu W, Liang Y, Wang L, Song X, Su S, Gao H, Jiang J, Li J, Luo M, Gao F, Chen Q, Li W, Chen ZJ
The EMBO journal 2021 Jul 1;40(13):e106864
The EMBO journal 2021 Jul 1;40(13):e106864
miR-937-5p targets SOX17 to modulate breast cancer cell cycle and cell proliferation through the Wnt signaling pathway.
Xiong X, Xu W, Gong J, Wang L, Dai M, Chen G, Yuan L
Cellular signalling 2021 Jan;77:109818
Cellular signalling 2021 Jan;77:109818
Expression, Localization, and Function of the Nucleolar Protein BOP1 in Prostate Cancer Progression.
Vellky JE, Ricke EA, Huang W, Ricke WA
The American journal of pathology 2021 Jan;191(1):168-179
The American journal of pathology 2021 Jan;191(1):168-179
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
Guo H, Wang Y, Jia W, Liu L
Physiological research 2021 Jan 14;70(1)
Physiological research 2021 Jan 14;70(1)
CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis.
Huang YH, Cai K, Xu PP, Wang L, Huang CX, Fang Y, Cheng S, Sun XJ, Liu F, Huang JY, Ji MM, Zhao WL
Signal transduction and targeted therapy 2021 Jan 11;6(1):10
Signal transduction and targeted therapy 2021 Jan 11;6(1):10
The transcriptional repressors VAL1 and VAL2 recruit PRC2 for genome-wide Polycomb silencing in Arabidopsis.
Yuan L, Song X, Zhang L, Yu Y, Liang Z, Lei Y, Ruan J, Tan B, Liu J, Li C
Nucleic acids research 2021 Jan 11;49(1):98-113
Nucleic acids research 2021 Jan 11;49(1):98-113
Protective Effects of Fisetin on Hepatic Ischemia-reperfusion Injury Through Alleviation of Apoptosis and Oxidative Stress.
Li Z, Wang Y, Zhang Y, Wang X, Gao B, Li Y, Li R, Wang J
Archives of medical research 2021 Feb;52(2):163-173
Archives of medical research 2021 Feb;52(2):163-173
Paeonol ameliorates CFA-induced inflammatory pain by inhibiting HMGB1/TLR4/NF-κB p65 pathway.
Qiu C, Yang LD, Yu W, Tian DD, Gao MR, Wang WJ, Li XB, Wu YM, Wang M
Metabolic brain disease 2021 Feb;36(2):273-283
Metabolic brain disease 2021 Feb;36(2):273-283
Panax notoginseng saponins promote endothelial progenitor cell angiogenesis via the Wnt/β-catenin pathway.
Zhu P, Jiang W, He S, Zhang T, Liao F, Liu D, An X, Huang X, Zhou N
BMC complementary medicine and therapies 2021 Feb 8;21(1):53
BMC complementary medicine and therapies 2021 Feb 8;21(1):53
p53 induces ARTS to promote mitochondrial apoptosis.
Hao Q, Chen J, Liao J, Huang Y, Gan Y, Larisch S, Zeng SX, Lu H, Zhou X
Cell death & disease 2021 Feb 24;12(2):204
Cell death & disease 2021 Feb 24;12(2):204
HDAC9 in the Injury of Vascular Endothelial Cell Mediated by P38 MAPK Pathway.
Kuang X, Chen S, Lao J, Chen Y, Jia D, Tu L, Ma L, Liao X, Zhao W, Li Q
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2021 Dec;41(12):439-449
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2021 Dec;41(12):439-449
ChREBP deficiency alleviates apoptosis by inhibiting TXNIP/oxidative stress in diabetic nephropathy.
Chen N, Song S, Yang Z, Wu M, Mu L, Zhou T, Shi Y
Journal of diabetes and its complications 2021 Dec;35(12):108050
Journal of diabetes and its complications 2021 Dec;35(12):108050
Histone H3 lysine-trimethylation markers are decreased by recombinant methioninase and increased by methotrexate at concentrations which inhibit methionine-addicted osteosarcoma cell proliferation.
Aoki Y, Tome Y, Han Q, Yamamoto J, Hamada K, Masaki N, Bouvet M, Nishida K, Hoffman RM
Biochemistry and biophysics reports 2021 Dec;28:101177
Biochemistry and biophysics reports 2021 Dec;28:101177
Stress-induced phosphoprotein 1 restrains spinal cord ischaemia-reperfusion injury by modulating NF-κB signalling.
Jin H, Ge X, Huan Z, Yao H, Xu C, Cai J
Journal of cellular and molecular medicine 2021 Dec;25(24):11075-11084
Journal of cellular and molecular medicine 2021 Dec;25(24):11075-11084
NOD2-mediated P2Y(12) upregulation increases platelet activation and thrombosis in sepsis.
Zhong H, Waresi M, Zhang W, Han L, Zhao Y, Chen Y, Zhou P, Chang L, Pan G, Wu B, Li J, Zhang S, Shi H, Luo X, Gao W, Qi Z, Ding Z
Biochemical pharmacology 2021 Dec;194:114822
Biochemical pharmacology 2021 Dec;194:114822
Pretreatment of Indobufen and Aspirin and their Combinations with Clopidogrel or Ticagrelor Alleviates Inflammasome Mediated Pyroptosis Via Inhibiting NF-κB/NLRP3 Pathway in Ischemic Stroke.
Li F, Xu D, Hou K, Gou X, Lv N, Fang W, Li Y
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2021 Dec;16(4):835-853
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2021 Dec;16(4):835-853
Pentagalloylglucose reduces AGE-induced inflammation by activating Nrf2/HO-1 and inhibiting the JAK2/STAT3 pathway in mesangial cells.
Tong J, Fang J, Zhu T, Xiang P, Shang J, Chen L, Zhao J, Wang Y, Tong L, Sun M
Journal of pharmacological sciences 2021 Dec;147(4):305-314
Journal of pharmacological sciences 2021 Dec;147(4):305-314
Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia.
Li M, Lu H, Wang X, Duan C, Zhu X, Zhang Y, Ge X, Ji F, Wang X, Su J, Zhang D
Molecular immunology 2021 Dec;140:250-266
Molecular immunology 2021 Dec;140:250-266
Peony seed oil ameliorates neuroinflammation-mediated cognitive deficits by suppressing microglial activation through inhibition of NF-κB pathway in presenilin 1/2 conditional double knockout mice.
Gao J, Wang L, Zhao C, Wu Y, Lu Z, Gu Y, Ba Z, Wang X, Wang J, Xu Y
Journal of leukocyte biology 2021 Dec;110(6):1005-1022
Journal of leukocyte biology 2021 Dec;110(6):1005-1022
miR-140-3p enhanced the osteo/odontogenic differentiation of DPSCs via inhibiting KMT5B under hypoxia condition.
Zheng H, Wang N, Li L, Ge L, Jia H, Fan Z
International journal of oral science 2021 Dec 7;13(1):41
International journal of oral science 2021 Dec 7;13(1):41
Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer.
Huang D, Chowdhury S, Wang H, Savage SR, Ivey RG, Kennedy JJ, Whiteaker JR, Lin C, Hou X, Oberg AL, Larson MC, Eskandari N, Delisi DA, Gentile S, Huntoon CJ, Voytovich UJ, Shire ZJ, Yu Q, Gygi SP, Hoofnagle AN, Herbert ZT, Lorentzen TD, Calinawan A, Karnitz LM, Weroha SJ, Kaufmann SH, Zhang B, Wang P, Birrer MJ, Paulovich AG
Cell reports. Medicine 2021 Dec 21;2(12):100471
Cell reports. Medicine 2021 Dec 21;2(12):100471
Curcumin hinders PBDE-47-induced neutrophil extracellular traps release via Nrf2-associated ROS inhibition.
Ye S, Li S, Ma Y, Hu D, Xiao F
Ecotoxicology and environmental safety 2021 Dec 1;225:112779
Ecotoxicology and environmental safety 2021 Dec 1;225:112779
Protective effects of oridonin against cerebral ischemia/reperfusion injury by inhibiting the NLRP3 inflammasome activation.
Jia Y, Tong Y, Min L, Li Y, Cheng Y
Tissue & cell 2021 Aug;71:101514
Tissue & cell 2021 Aug;71:101514
Histone H2B ubiquitination mediated chromatin relaxation is essential for the induction of somatic cell reprogramming.
Wang L, Xu Z, Wang L, Liu C, Wei H, Zhang R, Chen Y, Wang L, Liu W, Xiao S, Li W, Li W
Cell proliferation 2021 Aug;54(8):e13080
Cell proliferation 2021 Aug;54(8):e13080
Glutaredoxin 1 protects neurons from oxygen-glucose deprivation/reoxygenation (OGD/R)-induced apoptosis and oxidative stress via the modulation of GSK-3β/Nrf2 signaling.
Qiu Z, Li X, Duan C, Li R, Han L
Journal of bioenergetics and biomembranes 2021 Aug;53(4):369-379
Journal of bioenergetics and biomembranes 2021 Aug;53(4):369-379
PLK2 protects retinal ganglion cells from oxidative stress by potentiating Nrf2 signaling via GSK-3β.
Fan Y, Wang J, He N, Feng H
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22815
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22815
Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage.
Dai C, Wu B, Chen Y, Li X, Bai Y, Du Y, Pang Y, Wang YT, Dong Z
Cell death and differentiation 2021 Aug;28(8):2367-2384
Cell death and differentiation 2021 Aug;28(8):2367-2384
CDDO-Im exerts antidepressant-like effects via the Nrf2/ARE pathway in a rat model of post-stroke depression.
Hou X, Liu H, Ping Y, Zhang F, Zhi L, Jiang X, Zhang F, Song C, Zhang Z, Song J
Brain research bulletin 2021 Aug;173:74-81
Brain research bulletin 2021 Aug;173:74-81
Virtual screening identified natural Keap1-Nrf2 PPI inhibitor alleviates inflammatory osteoporosis through Nrf2-mir214-Traf3 axis.
Hong J, Shi Z, Li C, Ji X, Li S, Chen Y, Jiang G, Shi M, Wang W, Zhang Y, Hu B, Yan S
Free radical biology & medicine 2021 Aug 1;171:365-378
Free radical biology & medicine 2021 Aug 1;171:365-378
Downregulation of miR-497-5p prevents liver ischemia-reperfusion injury in association with MED1/TIMP-2 axis and the NF-κB pathway.
Wu K, Tao G, Xu T, An Y, Yu X, Wang Y, Wang S, Guo W, Ma L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Apr;35(4):e21180
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Apr;35(4):e21180
GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis.
Yang X, Cong T, He H, Wang J
Blood science (Baltimore, Md.) 2021 Apr;3(2):40-47
Blood science (Baltimore, Md.) 2021 Apr;3(2):40-47
Programmed cell death 4 modulates lysosomal function by inhibiting TFEB translation.
Chen X, Guan Y, Zhang Y, Jia Y, Li W, Guo C, Li Y, Wang X, Shi Y, Wang Q, Zhu F, Li Y, Zhang L
Cell death and differentiation 2021 Apr;28(4):1237-1250
Cell death and differentiation 2021 Apr;28(4):1237-1250
Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis.
Zhang Y, Huang W, Zheng Z, Wang W, Yuan Y, Hong Q, Lin J, Li X, Meng Y
Free radical biology & medicine 2021 Apr;166:116-127
Free radical biology & medicine 2021 Apr;166:116-127
ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H(+)-ATPases is essential for brain development in humans and mice.
Aoto K, Kato M, Akita T, Nakashima M, Mutoh H, Akasaka N, Tohyama J, Nomura Y, Hoshino K, Ago Y, Tanaka R, Epstein O, Ben-Haim R, Heyman E, Miyazaki T, Belal H, Takabayashi S, Ohba C, Takata A, Mizuguchi T, Miyatake S, Miyake N, Fukuda A, Matsumoto N, Saitsu H
Nature communications 2021 Apr 8;12(1):2107
Nature communications 2021 Apr 8;12(1):2107
Impaired 26S Proteasome Assembly Precedes Neuronal Loss in Mutant UBQLN2 Rats.
Zhang W, Huang B, Gao L, Huang C
International journal of molecular sciences 2021 Apr 21;22(9)
International journal of molecular sciences 2021 Apr 21;22(9)
5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats.
Liu L, Zhang P, Zhang Z, Liang Y, Chen H, He Z, Sun X, Guo Z, Deng Y
Aging 2021 Apr 20;13(8):11752-11761
Aging 2021 Apr 20;13(8):11752-11761
Glaucocalyxin A induces cell cycle arrest and apoptosis via inhibiting NF-κB/p65 signaling pathway in melanoma cells.
Chen J, Zhang W, Pan C, Fan J, Zhong X, Tang S
Life sciences 2021 Apr 15;271:119185
Life sciences 2021 Apr 15;271:119185
Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA-cGAS-STING Signaling Axis.
Torres-Odio S, Lei Y, Gispert S, Maletzko A, Key J, Menissy SS, Wittig I, Auburger G, West AP
Journal of immunology (Baltimore, Md. : 1950) 2021 Apr 15;206(8):1890-1900
Journal of immunology (Baltimore, Md. : 1950) 2021 Apr 15;206(8):1890-1900
PD-L1 lncRNA splice isoform promotes lung adenocarcinoma progression via enhancing c-Myc activity.
Qu S, Jiao Z, Lu G, Yao B, Wang T, Rong W, Xu J, Fan T, Sun X, Yang R, Wang J, Yao Y, Xu G, Yan X, Wang T, Liang H, Zen K
Genome biology 2021 Apr 13;22(1):104
Genome biology 2021 Apr 13;22(1):104
S-allyl cysteine ameliorates heat stress-induced oxidative stress by activating Nrf2/HO-1 signaling pathway in BMECs.
Wang Y, Wang HL, Xing GD, Qian Y, Zhong JF, Chen KL
Toxicology and applied pharmacology 2021 Apr 1;416:115469
Toxicology and applied pharmacology 2021 Apr 1;416:115469
Laminar Flow Protects Vascular Endothelial Tight Junctions and Barrier Function via Maintaining the Expression of Long Non-coding RNA MALAT1.
Yang F, Zhang Y, Zhu J, Wang J, Jiang Z, Zhao C, Yang Q, Huang Y, Yao W, Pang W, Han L, Zhou J
Frontiers in bioengineering and biotechnology 2020;8:647
Frontiers in bioengineering and biotechnology 2020;8:647
MiR-146a-5p Mimic Inhibits NLRP3 Inflammasome Downstream Inflammatory Factors and CLIC4 in Neonatal Necrotizing Enterocolitis.
Chen J, Chen T, Zhou J, Zhao X, Sheng Q, Lv Z
Frontiers in cell and developmental biology 2020;8:594143
Frontiers in cell and developmental biology 2020;8:594143
miR-766-3p Targeting BCL9L Suppressed Tumorigenesis, Epithelial-Mesenchymal Transition, and Metastasis Through the β-Catenin Signaling Pathway in Osteosarcoma Cells.
Zhang S, Chen H, Liu W, Fang L, Qian Z, Kong R, Zhang Q, Li J, Cao X
Frontiers in cell and developmental biology 2020;8:594135
Frontiers in cell and developmental biology 2020;8:594135
LncRNA MALAT1 Affects Mycoplasma pneumoniae Pneumonia via NF-κB Regulation.
Gu H, Zhu Y, Zhou Y, Huang T, Zhang S, Zhao D, Liu F
Frontiers in cell and developmental biology 2020;8:563693
Frontiers in cell and developmental biology 2020;8:563693
A Novel STAT3-Mediated GATA6 Pathway Contributes to tert-Butylhydroquinone- (tBHQ-) Protected TNFα-Activated Vascular Cell Adhesion Molecule 1 (VCAM-1) in Vascular Endothelium.
Zhou L, Ning H, Wei H, Xu T, Zhao X, Fu A, Qian Q, Yang Z, Dou X, Li S
Oxidative medicine and cellular longevity 2020;2020:6584059
Oxidative medicine and cellular longevity 2020;2020:6584059
CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor.
Li T, Cai X, Wang X, Zhang X, Zhang H, Xu B, Li S, Hu J, Wu Q
Journal of diabetes research 2020;2020:2789209
Journal of diabetes research 2020;2020:2789209
MFP-FePt-GO Nanocomposites Promote Radiosensitivity of Non-Small Cell Lung Cancer Via Activating Mitochondrial-Mediated Apoptosis and Impairing DNA Damage Repair.
Peng S, Sun Y, Luo Y, Ma S, Sun W, Tang G, Li S, Zhang N, Ren J, Xiao Y, Liu X, Zhang J, Gong Y, Xie C
International journal of biological sciences 2020;16(12):2145-2158
International journal of biological sciences 2020;16(12):2145-2158
Sevoflurane Exposure Induces Neuronal Cell Parthanatos Initiated by DNA Damage in the Developing Brain via an Increase of Intracellular Reactive Oxygen Species.
Piao M, Wang Y, Liu N, Wang X, Chen R, Qin J, Ge P, Feng C
Frontiers in cellular neuroscience 2020;14:583782
Frontiers in cellular neuroscience 2020;14:583782
RGFP966 Suppresses Tumor Growth and Migration Through Inhibition of EGFR Expression in Hepatocellular Carcinoma Cells in vitro.
Yu X, Yang F, Jiang H, Fan L
Drug design, development and therapy 2020;14:121-128
Drug design, development and therapy 2020;14:121-128
Spinal N-Cadherin/CREB Signaling Contributes to Chronic Alcohol Consumption-Enhanced Postsurgical Pain.
Ma Y, Zhang X, Li C, Liu S, Xing Y, Tao F
Journal of pain research 2020;13:2065-2072
Journal of pain research 2020;13:2065-2072
lncRNA PCBP1-AS1 Aggravates the Progression of Hepatocellular Carcinoma via Regulating PCBP1/PRL-3/AKT Pathway.
Luo T, Gao Y, Zhangyuan G, Xu X, Xue C, Jin L, Zhang W, Zhu C, Sun B, Qin X
Cancer management and research 2020;12:5395-5408
Cancer management and research 2020;12:5395-5408
NFE2L3 promotes malignant behavior and EMT of human hepatocellular carcinoma (HepG2) cells via Wnt/β‑catenin pathway.
Ren Y, Wang Y, Hao S, Yang Y, Xiong W, Qiu L, Tao J, Tang A
Journal of Cancer 2020;11(23):6939-6949
Journal of Cancer 2020;11(23):6939-6949
Oxymatrine Inhibits Renal Cell Carcinoma Progression by Suppressing β-Catenin Expression.
Jin Y, Liu J, Liu Y, Liu Y, Guo G, Yu S, An R
Frontiers in pharmacology 2020;11:808
Frontiers in pharmacology 2020;11:808
Oxymatrine Attenuates Dopaminergic Neuronal Damage and Microglia-Mediated Neuroinflammation Through Cathepsin D-Dependent HMGB1/TLR4/NF-κB Pathway in Parkinson's Disease.
Gan P, Ding L, Hang G, Xia Q, Huang Z, Ye X, Qian X
Frontiers in pharmacology 2020;11:776
Frontiers in pharmacology 2020;11:776
TRIM59 Protects Mice From Sepsis by Regulating Inflammation and Phagocytosis in Macrophages.
Jin Z, Zhu Z, Liu S, Hou Y, Tang M, Zhu P, Tian Y, Li D, Yan D, Zhu X
Frontiers in immunology 2020;11:263
Frontiers in immunology 2020;11:263
Poricoic acid A as a modulator of TPH-1 expression inhibits renal fibrosis via modulating protein stability of β-catenin and β-catenin-mediated transcription.
Chen DQ, Wu XQ, Chen L, Hu HH, Wang YN, Zhao YY
Therapeutic advances in chronic disease 2020;11:2040622320962648
Therapeutic advances in chronic disease 2020;11:2040622320962648
MicroRNA-34a Inhibition Alleviates Lung Injury in Cecal Ligation and Puncture Induced Septic Mice.
Chen S, Ding R, Hu Z, Yin X, Xiao F, Zhang W, Yan S, Lv C
Frontiers in immunology 2020;11:1829
Frontiers in immunology 2020;11:1829
Extracellular Vesicles From Adipose Tissue-Derived Stem Cells Affect Notch-miR148a-3p Axis to Regulate Polarization of Macrophages and Alleviate Sepsis in Mice.
Bai X, Li J, Li L, Liu M, Liu Y, Cao M, Tao K, Xie S, Hu D
Frontiers in immunology 2020;11:1391
Frontiers in immunology 2020;11:1391
Antiviral Activity of Feline BCA2 Is Mainly Dependent on Its Interference With Proviral Transcription Rather Than Degradation of FIV Gag.
Qu M, Wang W, Li W, Cao J, Zhang X, Wang C, Wu J, Yu B, Zhang H, Wu H, Kong W, Yu X
Frontiers in microbiology 2020;11:1230
Frontiers in microbiology 2020;11:1230
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.
Zhou K, Zheng Z, Li Y, Han W, Zhang J, Mao Y, Chen H, Zhang W, Liu M, Xie L, Zhang H, Xu H, Xiao J
Theranostics 2020;10(20):9280-9302
Theranostics 2020;10(20):9280-9302
N(6)-Methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2.
Li Y, Xia L, Tan K, Ye X, Zuo Z, Li M, Xiao R, Wang Z, Liu X, Deng M, Cui J, Yang M, Luo Q, Liu S, Cao X, Zhu H, Liu T, Hu J, Shi J, Xiao S, Xia L
Nature genetics 2020 Sep;52(9):870-877
Nature genetics 2020 Sep;52(9):870-877
HMGB1 Inhibits HNF1A to Modulate Liver Fibrogenesis via p65/miR-146b Signaling.
Ge S, Wu X, Xiong Y, Xie J, Liu F, Zhang W, Yang L, Zhang S, Lai L, Huang J, Li M, Yu YQ
DNA and cell biology 2020 Sep;39(9):1711-1722
DNA and cell biology 2020 Sep;39(9):1711-1722
Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis.
Wang H, Wang N, Xu D, Ma Q, Chen Y, Xu S, Xia Q, Zhang Y, Prehn JHM, Wang G, Ying Z
Autophagy 2020 Sep;16(9):1683-1696
Autophagy 2020 Sep;16(9):1683-1696
CLPTM1L induces estrogen receptor β signaling-mediated radioresistance in non-small cell lung cancer cells.
Li H, Che J, Jiang M, Cui M, Feng G, Dong J, Zhang S, Lu L, Liu W, Fan S
Cell communication and signaling : CCS 2020 Sep 17;18(1):152
Cell communication and signaling : CCS 2020 Sep 17;18(1):152
Camptothecin induced DDX5 degradation increased the camptothecin resistance of osteosarcoma.
Zhao X, Bao M, Zhang F, Wang W
Experimental cell research 2020 Sep 15;394(2):112148
Experimental cell research 2020 Sep 15;394(2):112148
FERMT1 promotes gastric cancer progression by activating the NF-κB pathway and predicts poor prognosis.
Fan H, Zhang S, Zhang Y, Liang W, Cao B
Cancer biology & therapy 2020 Sep 1;21(9):815-825
Cancer biology & therapy 2020 Sep 1;21(9):815-825
The interaction of lead exposure and CCM3 defect plays an important role in regulating angiogenesis through eNOS/NO pathway.
Sun Y, Zhao Z, Zhang H, Li J, Chen J, Luan X, Min W, He Y
Environmental toxicology and pharmacology 2020 Oct;79:103407
Environmental toxicology and pharmacology 2020 Oct;79:103407
An NF-κB-driven lncRNA orchestrates colitis and circadian clock.
Wang S, Lin Y, Li F, Qin Z, Zhou Z, Gao L, Yang Z, Wang Z, Wu B
Science advances 2020 Oct;6(42)
Science advances 2020 Oct;6(42)
Zbtb20 deficiency causes cardiac contractile dysfunction in mice.
Ren AJ, Chen C, Zhang S, Liu M, Wei C, Wang K, Ma X, Song Y, Wang R, Zhang H, Chen YX, Wu H, Xie Z, Zhang Y, Zhang WJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Oct;34(10):13862-13876
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Oct;34(10):13862-13876
Emodin inhibiting neutrophil elastase-induced epithelial-mesenchymal transition through Notch1 signalling in alveolar epithelial cells.
Zhou L, Gao R, Hong H, Li X, Yang J, Shen W, Wang Z, Yang J
Journal of cellular and molecular medicine 2020 Oct;24(20):11998-12007
Journal of cellular and molecular medicine 2020 Oct;24(20):11998-12007
Mechanisms by which electroacupuncture‑mediated histone acetylation mitigates bone loss in rats with ovariectomy‑induced osteoporosis.
Shu Q, Shao Y, Liu R, Hu Y, Peng Z, Tian J
Molecular medicine reports 2020 Oct;22(4):3453-3463
Molecular medicine reports 2020 Oct;22(4):3453-3463
Histone chaperone FACT represses retrotransposon MERVL and MERVL-derived cryptic promoters.
Chen F, Zhang W, Xie D, Gao T, Dong Z, Lu X
Nucleic acids research 2020 Oct 9;48(18):10211-10225
Nucleic acids research 2020 Oct 9;48(18):10211-10225
Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation.
Wu L, Lin W, Liao Q, Wang H, Lin C, Tang L, Lian W, Chen Z, Li K, Xu L, Zhou R, Ding Y, Zhao L
Cell reports 2020 Oct 27;33(4):108327
Cell reports 2020 Oct 27;33(4):108327
Rosmarinic Acid Alleviates Inflammation, Apoptosis, and Oxidative Stress through Regulating miR-155-5p in a Mice Model of Parkinson's Disease.
Lv R, Du L, Zhou F, Yuan X, Liu X, Zhang L
ACS chemical neuroscience 2020 Oct 21;11(20):3259-3266
ACS chemical neuroscience 2020 Oct 21;11(20):3259-3266
Ochratoxin A induces reprogramming of glucose metabolism by switching energy metabolism from oxidative phosphorylation to glycolysis in human gastric epithelium GES-1 cells in vitro.
Wang Y, Zhao M, Cui J, Wu X, Li Y, Wu W, Zhang X
Toxicology letters 2020 Oct 15;333:232-241
Toxicology letters 2020 Oct 15;333:232-241
Echinacea polysaccharide alleviates LPS-induced lung injury via inhibiting inflammation, apoptosis and activation of the TLR4/NF-κB signal pathway.
Zhang H, Lang W, Wang S, Li B, Li G, Shi Q
International immunopharmacology 2020 Nov;88:106974
International immunopharmacology 2020 Nov;88:106974
The molecular basis of tight nuclear tethering and inactivation of cGAS.
Zhao B, Xu P, Rowlett CM, Jing T, Shinde O, Lei Y, West AP, Liu WR, Li P
Nature 2020 Nov;587(7835):673-677
Nature 2020 Nov;587(7835):673-677
Berberine protects against diabetic retinopathy by inhibiting cell apoptosis via deactivation of the NF‑κB signaling pathway.
Zhai J, Li Z, Zhang H, Ma L, Ma Z, Zhang Y, Zou J, Li M, Ma L, Wang X, Li X
Molecular medicine reports 2020 Nov;22(5):4227-4235
Molecular medicine reports 2020 Nov;22(5):4227-4235
Insulin Promotes Corneal Nerve Repair and Wound Healing in Type 1 Diabetic Mice by Enhancing Wnt/β-Catenin Signaling.
Yang S, Zhang Y, Zhang Z, Dan J, Zhou Q, Wang X, Li W, Zhou L, Yang L, Xie L
The American journal of pathology 2020 Nov;190(11):2237-2250
The American journal of pathology 2020 Nov;190(11):2237-2250
Interaction of BACH2 with FUS promotes malignant progression of glioma cells via the TSLNC8-miR-10b-5p-WWC3 pathway.
Yang Y, Liu X, Zheng J, Xue Y, Liu L, Ma J, Wang P, Yang C, Wang D, Shao L, Ruan X, Liu Y
Molecular oncology 2020 Nov;14(11):2936-2959
Molecular oncology 2020 Nov;14(11):2936-2959
Active Peptide KF-8 from Rice Bran Attenuates Oxidative Stress in a Mouse Model of Aging Induced by d-Galactose.
Wang Y, Cui X, Lin Q, Cai J, Tang L, Liang Y
Journal of agricultural and food chemistry 2020 Nov 4;68(44):12271-12283
Journal of agricultural and food chemistry 2020 Nov 4;68(44):12271-12283
Acetylharpagide Protects Mice from Staphylococcus Aureus-Induced Acute Lung Injury by Inhibiting NF-κB Signaling Pathway.
Zhang Z, Wang Y, Shan Y, Yin W
Molecules (Basel, Switzerland) 2020 Nov 25;25(23)
Molecules (Basel, Switzerland) 2020 Nov 25;25(23)
Targeting the NCOA3-SP1-TERT axis for tumor growth in hepatocellular carcinoma.
Li W, Yan Y, Zheng Z, Zhu Q, Long Q, Sui S, Luo M, Chen M, Li Y, Hua Y, Deng W, Lai R, Li L
Cell death & disease 2020 Nov 25;11(11):1011
Cell death & disease 2020 Nov 25;11(11):1011
ARID1A-dependent permissive chromatin accessibility licenses estrogen-receptor signaling to regulate circadian rhythms genes in endometrial cancer.
Hu H, Chen Z, Ji L, Wang Y, Yang M, Lai R, Zhong Y, Zhang X, Wang L
Cancer letters 2020 Nov 1;492:162-173
Cancer letters 2020 Nov 1;492:162-173
PIGU promotes hepatocellular carcinoma progression through activating NF-κB pathway and increasing immune escape.
Wei X, Yang W, Zhang F, Cheng F, Rao J, Lu L
Life sciences 2020 Nov 1;260:118476
Life sciences 2020 Nov 1;260:118476
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Wang Y, Chen J, Li S, Zhang X, Guo Z, Hu J, Shao X, Song N, Zhao Y, Li H, Yang G, Xu C, Wei C
Redox biology 2020 May;32:101514
Redox biology 2020 May;32:101514
Valproic acid targets HDAC1/2 and HDAC1/PTEN/Akt signalling to inhibit cell proliferation via the induction of autophagy in gastric cancer.
Sun J, Piao J, Li N, Yang Y, Kim KY, Lin Z
The FEBS journal 2020 May;287(10):2118-2133
The FEBS journal 2020 May;287(10):2118-2133
Functional analysis of MTF-1 and MT promoters and their transcriptional response to zinc (Zn) and copper (Cu) in yellow catfish Pelteobagrus fulvidraco.
Chen GH, Lv W, Xu YH, Wei XL, Xu YC, Luo Z
Chemosphere 2020 May;246:125792
Chemosphere 2020 May;246:125792
Pseudorabies Virus Infection of Epithelial Cells Leads to Persistent but Aberrant Activation of the NF-κB Pathway, Inhibiting Hallmark NF-κB-Induced Proinflammatory Gene Expression.
Romero N, Van Waesberghe C, Favoreel HW
Journal of virology 2020 May 4;94(10)
Journal of virology 2020 May 4;94(10)
The bromodomain containing protein BRD-9 orchestrates RAD51-RAD54 complex formation and regulates homologous recombination-mediated repair.
Zhou Q, Huang J, Zhang C, Zhao F, Kim W, Tu X, Zhang Y, Nowsheen S, Zhu Q, Deng M, Chen Y, Qin B, Luo K, Liu B, Lou Z, Mutter RW, Yuan J
Nature communications 2020 May 26;11(1):2639
Nature communications 2020 May 26;11(1):2639
USP38 regulates the stemness and chemoresistance of human colorectal cancer via regulation of HDAC3.
Zhan W, Liao X, Liu J, Tian T, Yu L, Li R
Oncogenesis 2020 May 13;9(5):48
Oncogenesis 2020 May 13;9(5):48
Comprehensive identification of signaling pathways for idiopathic pulmonary arterial hypertension.
Liu B, Zhu L, Yuan P, Marsboom G, Hong Z, Liu J, Zhang P, Hu Q
American journal of physiology. Cell physiology 2020 May 1;318(5):C913-C930
American journal of physiology. Cell physiology 2020 May 1;318(5):C913-C930
δ-Catenin regulates proliferation and apoptosis in renal cell carcinoma via promoting β-catenin nuclear localization and activating its downstream target genes.
Ju L, Shan L, Yin B, Song Y
Cancer medicine 2020 Mar;9(6):2201-2212
Cancer medicine 2020 Mar;9(6):2201-2212
Bclaf1 is a direct target of HIF-1 and critically regulates the stability of HIF-1α under hypoxia.
Shao A, Lang Y, Wang M, Qin C, Kuang Y, Mei Y, Lin D, Zhang S, Tang J
Oncogene 2020 Mar;39(13):2807-2818
Oncogene 2020 Mar;39(13):2807-2818
The Wnt/β-catenin/VASP positive feedback loop drives cell proliferation and migration in breast cancer.
Li K, Zhang J, Tian Y, He Y, Xu X, Pan W, Gao Y, Chen F, Wei L
Oncogene 2020 Mar;39(11):2258-2274
Oncogene 2020 Mar;39(11):2258-2274
NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.
He X, Yang W, Zeng Z, Wei Y, Gao J, Zhang B, Li L, Liu L, Wan Y, Zeng Q, Gong Z, Liu L, Zhang H, Li Y, Yang S, Hu T, Wu L, Masliah E, Huang S, Cao H
Cellular & molecular immunology 2020 Mar;17(3):283-299
Cellular & molecular immunology 2020 Mar;17(3):283-299
TGFB1-induced autophagy affects the pattern of pancreatic cancer progression in distinct ways depending on SMAD4 status.
Liang C, Xu J, Meng Q, Zhang B, Liu J, Hua J, Zhang Y, Shi S, Yu X
Autophagy 2020 Mar;16(3):486-500
Autophagy 2020 Mar;16(3):486-500
LYW-6, a novel cryptotanshinone derived STAT3 targeting inhibitor, suppresses colorectal cancer growth and metastasis.
Wang H, Liu Z, Guan L, Li J, Chen S, Yu W, Lai M
Pharmacological research 2020 Mar;153:104661
Pharmacological research 2020 Mar;153:104661
Notch signal deficiency alleviates hypertrophic scar formation after wound healing through the inhibition of inflammation.
He T, Bai X, Jing J, Liu Y, Wang H, Zhang W, Li X, Li Y, Wang L, Xie S, Hu D
Archives of biochemistry and biophysics 2020 Mar 30;682:108286
Archives of biochemistry and biophysics 2020 Mar 30;682:108286
Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition.
Fan C, Zhong T, Yang H, Yang Y, Wang D, Yang X, Xu Y, Fan Y
European journal of medicinal chemistry 2020 Mar 15;190:112108
European journal of medicinal chemistry 2020 Mar 15;190:112108
ABA-responsive ABRE-BINDING FACTOR3 activates DAM3 expression to promote bud dormancy in Asian pear.
Yang Q, Yang B, Li J, Wang Y, Tao R, Yang F, Wu X, Yan X, Ahmad M, Shen J, Bai S, Teng Y
Plant, cell & environment 2020 Jun;43(6):1360-1375
Plant, cell & environment 2020 Jun;43(6):1360-1375
Inhibition of PIM1 attenuates the stem cell-like traits of breast cancer cells by promoting RUNX3 nuclear retention.
Liu H, Chen C, Ma D, Li Y, Yin Q, Li Q, Xiang C
Journal of cellular and molecular medicine 2020 Jun;24(11):6308-6323
Journal of cellular and molecular medicine 2020 Jun;24(11):6308-6323
Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway.
Dong X, Wu D, Zhang Y, Jia L, Pan X, Sun J, Pan LL
Antioxidants (Basel, Switzerland) 2020 Jun 5;9(6)
Antioxidants (Basel, Switzerland) 2020 Jun 5;9(6)
The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor.
Ouyang L, Yan B, Liu Y, Mao C, Wang M, Liu N, Wang Z, Liu S, Shi Y, Chen L, Wang X, Cheng Y, Cao Y, Xiao D, Zhang L, Liu S, Tao Y
Signal transduction and targeted therapy 2020 Jun 17;5(1):78
Signal transduction and targeted therapy 2020 Jun 17;5(1):78
Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways.
Ma Z, Lu Y, Yang F, Li S, He X, Gao Y, Zhang G, Ren E, Wang Y, Kang X
Toxicology and applied pharmacology 2020 Jun 15;397:115014
Toxicology and applied pharmacology 2020 Jun 15;397:115014
Non-Esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway.
Wang Y, Li C, Li J, Wang G, Li L
Antioxidants (Basel, Switzerland) 2020 Jun 14;9(6)
Antioxidants (Basel, Switzerland) 2020 Jun 14;9(6)
Deletion of newly described pro-survival molecule Pellino-1 increases oxidative stress, downregulates cIAP2/NF-κB cell survival pathway, reduces angiogenic response, and thereby aggravates tissue function in mouse ischemic models.
Selvaraju V, Thirunavukkarasu M, Joshi M, Oriowo B, Shaikh IA, Rishi MT, Tapias L, Coca-Soliz V, Saad I, Campbell J, Pradeep SR, Swaminathan S, Yee SP, McFadden DW, Alexander Palesty J, Maulik N
Basic research in cardiology 2020 Jun 14;115(4):45
Basic research in cardiology 2020 Jun 14;115(4):45
CaCBL1 Acts as a Positive Regulator in Pepper Response to Ralstonia solanacearum.
Shen L, Yang S, Yang F, Guan D, He S
Molecular plant-microbe interactions : MPMI 2020 Jul;33(7):945-957
Molecular plant-microbe interactions : MPMI 2020 Jul;33(7):945-957
EHF promotes colorectal carcinoma progression by activating TGF-β1 transcription and canonical TGF-β signaling.
Wang L, Ai M, Nie M, Zhao L, Deng G, Hu S, Han Y, Zeng W, Wang Y, Yang M, Wang S
Cancer science 2020 Jul;111(7):2310-2324
Cancer science 2020 Jul;111(7):2310-2324
mTORC1-dependent TFEB nucleus translocation and pro-survival autophagy induced by zeolitic imidazolate framework-8.
Ding H, Song Y, Huang X, Wang L, Luo S, Zhang H, Pan H, Jiang W, Qian J, Yao G, Wen L, Zhang Y
Biomaterials science 2020 Jul 28;8(15):4358-4369
Biomaterials science 2020 Jul 28;8(15):4358-4369
(Pro)renin receptor contributes to hypoxia/reoxygenation-induced apoptosis and autophagy in myocardial cells via the beta-catenin signaling pathway.
Gao X, Zhang S, Wang D, Cheng Y, Jiang Y, Liu Y
Physiological research 2020 Jul 16;69(3):427-438
Physiological research 2020 Jul 16;69(3):427-438
Intracellular expression of arginine deiminase activates the mitochondrial apoptosis pathway by inhibiting cytosolic ferritin and inducing chromatin autophagy.
Feng Q, Bian X, Liu X, Wang Y, Zhou H, Ma X, Quan C, Yao Y, Zheng Z
BMC cancer 2020 Jul 16;20(1):665
BMC cancer 2020 Jul 16;20(1):665
TCF7L2 rs290487 C allele aberrantly enhances hepatic gluconeogenesis through allele-specific changes in transcription and chromatin binding.
Zhang X, Ye P, Huang H, Wang B, Dong F, Ling Q
Aging 2020 Jul 10;12(13):13365-13387
Aging 2020 Jul 10;12(13):13365-13387
Loganin and catalpol exert cooperative ameliorating effects on podocyte apoptosis upon diabetic nephropathy by targeting AGEs-RAGE signaling.
Chen Y, Chen J, Jiang M, Fu Y, Zhu Y, Jiao N, Liu L, Du Q, Wu H, Xu H, Sun J
Life sciences 2020 Jul 1;252:117653
Life sciences 2020 Jul 1;252:117653
Karyopherin α 2 promotes proliferation, migration and invasion through activating NF-κB/p65 signaling pathways in melanoma cells.
Yang F, Li S, Cheng Y, Li J, Han X
Life sciences 2020 Jul 1;252:117611
Life sciences 2020 Jul 1;252:117611
A Noncoding Regulatory RNAs Network Driven by Circ-CDYL Acts Specifically in the Early Stages Hepatocellular Carcinoma.
Wei Y, Chen X, Liang C, Ling Y, Yang X, Ye X, Zhang H, Yang P, Cui X, Ren Y, Xin X, Li H, Wang R, Wang W, Jiang F, Liu S, Ding J, Zhang B, Li L, Wang H
Hepatology (Baltimore, Md.) 2020 Jan;71(1):130-147
Hepatology (Baltimore, Md.) 2020 Jan;71(1):130-147
PCNA and GSK3β interact with each other to regulate H1299 lung adenocarcinoma cells apoptosis.
Liu XH, Tang DE, Dai Y, Gao XJ, Liu LX
Neoplasma 2020 Jan;67(1):15-26
Neoplasma 2020 Jan;67(1):15-26
CHK2-FOXK axis promotes transcriptional control of autophagy programs.
Chen Y, Wu J, Liang G, Geng G, Zhao F, Yin P, Nowsheen S, Wu C, Li Y, Li L, Kim W, Zhou Q, Huang J, Liu J, Zhang C, Guo G, Deng M, Tu X, Gao X, Liu Z, Chen Y, Lou Z, Luo K, Yuan J
Science advances 2020 Jan;6(1):eaax5819
Science advances 2020 Jan;6(1):eaax5819
MiR-146a down-regulates inflammatory response by targeting TLR3 and TRAF6 in Coxsackievirus B infection.
Fei Y, Chaulagain A, Wang T, Chen Y, Liu J, Yi M, Wang Y, Huang Y, Lin L, Chen S, Xu W, Tong L, Wu X, Zhao D, Zhang F, Zhao W, Zhong Z
RNA (New York, N.Y.) 2020 Jan;26(1):91-100
RNA (New York, N.Y.) 2020 Jan;26(1):91-100
RNA binding protein FXR1-miR301a-3p axis contributes to p21WAF1 degradation in oral cancer.
Majumder M, Palanisamy V
PLoS genetics 2020 Jan;16(1):e1008580
PLoS genetics 2020 Jan;16(1):e1008580
GSPE alleviates renal fibrosis by inhibiting the activation of C3/ HMGB1/ TGF-β1 pathway.
Wang K, Wei H, Zhan J, Liang X, Zhang C, Liu Y, Xu G
Chemico-biological interactions 2020 Jan 25;316:108926
Chemico-biological interactions 2020 Jan 25;316:108926
Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt/Nrf2 signaling pathway.
Jia L, Xiong Y, Zhang W, Ma X, Xu X
Experimental cell research 2020 Jan 15;386(2):111717
Experimental cell research 2020 Jan 15;386(2):111717
Curcumin Protects Human Trophoblast HTR8/SVneo Cells from H(2)O(2)-Induced Oxidative Stress by Activating Nrf2 Signaling Pathway.
Qi L, Jiang J, Zhang J, Zhang L, Wang T
Antioxidants (Basel, Switzerland) 2020 Feb 1;9(2)
Antioxidants (Basel, Switzerland) 2020 Feb 1;9(2)
GDF15 induced by compressive force contributes to osteoclast differentiation in human periodontal ligament cells.
Li S, Li Q, Zhu Y, Hu W
Experimental cell research 2020 Feb 1;387(1):111745
Experimental cell research 2020 Feb 1;387(1):111745
GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.
Lang L, Xu B, Yuan J, Li S, Lian S, Chen Y, Guo J, Yang H
International immunopharmacology 2020 Dec;89(Pt B):106908
International immunopharmacology 2020 Dec;89(Pt B):106908
Protective effect of hydrogen sulfide on endothelial cells through Sirt1-FoxO1-mediated autophagy.
Zhu L, Duan W, Wu G, Zhang D, Wang L, Chen D, Chen Z, Yang B
Annals of translational medicine 2020 Dec;8(23):1586
Annals of translational medicine 2020 Dec;8(23):1586
Novel poricoic acids attenuate renal fibrosis through regulating redox signalling and aryl hydrocarbon receptor activation.
Wang M, Hu HH, Chen YY, Chen L, Wu XQ, Zhao YY
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Dec;79:153323
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Dec;79:153323
Exogenous CGRP Regulates Apoptosis and Autophagy to Alleviate Traumatic Brain Injury Through Akt/mTOR Signalling Pathway.
Tian J, Yang L, Wang P, Yang L, Fan Z
Neurochemical research 2020 Dec;45(12):2926-2938
Neurochemical research 2020 Dec;45(12):2926-2938
Glutathione S-transferases P1-mediated interleukin-6 in tumor-associated macrophages augments drug-resistance in MCF-7 breast cancer.
Dong X, Sun R, Wang J, Yu S, Cui J, Guo Z, Pan X, Sun J, Yang J, Pan LL
Biochemical pharmacology 2020 Dec;182:114289
Biochemical pharmacology 2020 Dec;182:114289
Silibinin ameliorats H(2)O(2)-induced cell apoptosis and oxidative stress response by activating Nrf2 signaling in trophoblast cells.
Guo H, Wang Y, Liu D
Acta histochemica 2020 Dec;122(8):151620
Acta histochemica 2020 Dec;122(8):151620
lncMGPF is a novel positive regulator of muscle growth and regeneration.
Lv W, Jin J, Xu Z, Luo H, Guo Y, Wang X, Wang S, Zhang J, Zuo H, Bai W, Peng Y, Tang J, Zhao S, Zuo B
Journal of cachexia, sarcopenia and muscle 2020 Dec;11(6):1723-1746
Journal of cachexia, sarcopenia and muscle 2020 Dec;11(6):1723-1746
Daphnetin ameliorates glucocorticoid-induced osteoporosis via activation of Wnt/GSK-3β/β-catenin signaling.
Wang Y, Chen J, Chen J, Dong C, Yan X, Zhu Z, Lu P, Song Z, Liu H, Chen S
Toxicology and applied pharmacology 2020 Dec 15;409:115333
Toxicology and applied pharmacology 2020 Dec 15;409:115333
Effects of taraxasterol against ethanol and high-fat diet-induced liver injury by regulating TLR4/MyD88/NF-κB and Nrf2/HO-1 signaling pathways.
Li Z, Lian Y, Wei R, Jin L, Cao H, Zhao T, Ma X, Zhong M, Gao Y, Zhang K
Life sciences 2020 Dec 1;262:118546
Life sciences 2020 Dec 1;262:118546
BRAHMA-interacting proteins BRIP1 and BRIP2 are core subunits of Arabidopsis SWI/SNF complexes.
Yu Y, Liang Z, Song X, Fu W, Xu J, Lei Y, Yuan L, Ruan J, Chen C, Fu W, Cui Y, Huang S, Li C
Nature plants 2020 Aug;6(8):996-1007
Nature plants 2020 Aug;6(8):996-1007
TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents.
Yang H, Chen Y, Jiang Y, Wang D, Yan J, Zhou Z
Experimental and therapeutic medicine 2020 Aug;20(2):1415-1422
Experimental and therapeutic medicine 2020 Aug;20(2):1415-1422
Hsa-miR-425-5p promotes tumor growth and metastasis by activating the CTNND1-mediated β-catenin pathway and EMT in colorectal cancer.
Liu D, Zhang H, Cui M, Chen C, Feng Y
Cell cycle (Georgetown, Tex.) 2020 Aug;19(15):1917-1927
Cell cycle (Georgetown, Tex.) 2020 Aug;19(15):1917-1927
AKT/FOXO1 axis links cross-talking of endothelial cell and pericyte in TIE2-mutated venous malformations.
Si Y, Huang J, Li X, Fu Y, Xu R, Du Y, Cheng J, Jiang H
Cell communication and signaling : CCS 2020 Aug 31;18(1):139
Cell communication and signaling : CCS 2020 Aug 31;18(1):139
Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease.
Sun B, Wang X, Liu X, Wang L, Ren F, Wang X, Leng X
Antioxidants (Basel, Switzerland) 2020 Aug 25;9(9)
Antioxidants (Basel, Switzerland) 2020 Aug 25;9(9)
1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells.
Jia Z, Zhang Y, Yan A, Wang M, Han Q, Wang K, Wang J, Qiao C, Pan Z, Chen C, Hu D, Ding X
Cell death & disease 2020 Aug 20;11(8):670
Cell death & disease 2020 Aug 20;11(8):670
Computational repositioning of dimethyl fumarate for treating alcoholic liver disease.
Zhang Y, Zhao S, Fu Y, Yan L, Feng Y, Chen Y, Wu Y, Deng Y, Zhang G, Chen Z, Chen Y, Liu T
Cell death & disease 2020 Aug 18;11(8):641
Cell death & disease 2020 Aug 18;11(8):641
Capsaicin suppressed activity of prostate cancer stem cells by inhibition of Wnt/β-catenin pathway.
Zhu M, Yu X, Zheng Z, Huang J, Yang X, Shi H
Phytotherapy research : PTR 2020 Apr;34(4):817-824
Phytotherapy research : PTR 2020 Apr;34(4):817-824
WISP-2, an upregulated gene in hip cartilage from the DDH model rats, induces chondrocyte apoptosis through PPARγ in vitro.
Ji X, Liu T, Zhao S, Li J, Li L, Wang E
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):4904-4917
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):4904-4917
C9orf72 associates with inactive Rag GTPases and regulates mTORC1-mediated autophagosomal and lysosomal biogenesis.
Wang M, Wang H, Tao Z, Xia Q, Hao Z, Prehn JHM, Zhen X, Wang G, Ying Z
Aging cell 2020 Apr;19(4):e13126
Aging cell 2020 Apr;19(4):e13126
PGN and LTA from Staphylococcus aureus Induced Inflammation and Decreased Lactation through Regulating DNA Methylation and Histone H3 Acetylation in Bovine Mammary Epithelial Cells.
Wu Y, Chen J, Sun Y, Dong X, Wang Z, Chen J, Dong G
Toxins 2020 Apr 9;12(4)
Toxins 2020 Apr 9;12(4)
Interaction between p53 and Ras signaling controls cisplatin resistance via HDAC4- and HIF-1α-mediated regulation of apoptosis and autophagy.
Zhang X, Qi Z, Yin H, Yang G
Theranostics 2019;9(4):1096-1114
Theranostics 2019;9(4):1096-1114
Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation.
Huang S, Wang LL, Xue NN, Li C, Guo HH, Ren TK, Zhan Y, Li WB, Zhang J, Chen XG, Han YX, Zhang JL, Jiang JD
Theranostics 2019;9(23):6745-6763
Theranostics 2019;9(23):6745-6763
Identification of RE1-Silencing Transcription Factor as a Promoter of Metastasis in Pancreatic Cancer.
Jin H, Liu P, Kong L, Fei X, Gao Y, Wu T, Sun D, Tan X
Frontiers in oncology 2019;9:291
Frontiers in oncology 2019;9:291
Role of Antioxidants in the Protection from Aging-Related Diseases.
Monti DM, Rigano MM, Monti SM, Peixoto HS
Oxidative medicine and cellular longevity 2019;2019:7450693
Oxidative medicine and cellular longevity 2019;2019:7450693
Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3K/AKT and Nrf2 Pathways.
Zhao K, Li Y, Wang Z, Han N, Wang Y
BioMed research international 2019;2019:4348973
BioMed research international 2019;2019:4348973
Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR.
Leng B, Zhang Y, Liu X, Zhang Z, Liu Y, Wang H, Lu M
Mediators of inflammation 2019;2019:1082497
Mediators of inflammation 2019;2019:1082497
Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.
Xue M, Liang H, Ji X, Liu Y, Ge Y, Hou L, Sun T
Nutrition & metabolism 2019;16:87
Nutrition & metabolism 2019;16:87
Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway.
Wu H, Ding J, Li S, Lin J, Jiang R, Lin C, Dai L, Xie C, Lin D, Xu H, Gao W, Zhou K
International journal of biological sciences 2019;15(2):325-340
International journal of biological sciences 2019;15(2):325-340
Liraglutide Improves Non-Alcoholic Fatty Liver Disease In Diabetic Mice By Modulating Inflammatory Signaling Pathways.
Luo Y, Yang P, Li Z, Luo Y, Shen J, Li R, Zheng H, Liang Y, Xia N
Drug design, development and therapy 2019;13:4065-4074
Drug design, development and therapy 2019;13:4065-4074
TFEB Probably Involved in Midazolam-Disturbed Lysosomal Homeostasis and Its Induced β-Amyloid Accumulation.
Cheng D, Tan Q, Zhu Q, Zhang J, Han X, Fang P, Jin W, Liu X
Frontiers in human neuroscience 2019;13:108
Frontiers in human neuroscience 2019;13:108
β-elemene inhibits radiation and hypoxia-induced macrophages infiltration via Prx-1/NF-κB/HIF-1α signaling pathway.
Yu X, Li Z, Zhang Y, Xu M, Che Y, Tian X, Wang R, Zou K, Zou L
OncoTargets and therapy 2019;12:4203-4211
OncoTargets and therapy 2019;12:4203-4211
Dl-3-n-Butylphthalide Exerts Dopaminergic Neuroprotection Through Inhibition of Neuroinflammation.
Chen Y, Wu T, Li H, Li X, Li Q, Zhu X, Yu M, Kuo SH, Huang F, Wu YC
Frontiers in aging neuroscience 2019;11:44
Frontiers in aging neuroscience 2019;11:44
Propofol Alleviates DNA Damage Induced by Oxygen Glucose Deprivation and Reperfusion via FoxO1 Nuclear Translocation in H9c2 Cells.
Zhou D, Zhuang J, Wang Y, Zhao D, Zhao L, Zhu S, Pu J, Yin M, Zhang H, Wang Z, Hong J
Frontiers in physiology 2019;10:223
Frontiers in physiology 2019;10:223
The Therapeutic Effects of Treadmill Exercise on Osteoarthritis in Rats by Inhibiting the HDAC3/NF-KappaB Pathway in vivo and in vitro.
Zhang H, Ji L, Yang Y, Wei Y, Zhang X, Gang Y, Lu J, Bai L
Frontiers in physiology 2019;10:1060
Frontiers in physiology 2019;10:1060
CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation.
Lu MC, Zhao J, Liu YT, Liu T, Tao MM, You QD, Jiang ZY
Redox biology 2019 Sep;26:101266
Redox biology 2019 Sep;26:101266
Bavachinin exhibits antitumor activity against non‑small cell lung cancer by targeting PPARγ.
Ge LN, Yan L, Li C, Cheng K
Molecular medicine reports 2019 Sep;20(3):2805-2811
Molecular medicine reports 2019 Sep;20(3):2805-2811
Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay.
Fish L, Navickas A, Culbertson B, Xu Y, Nguyen HCB, Zhang S, Hochman M, Okimoto R, Dill BD, Molina H, Najafabadi HS, Alarcón C, Ruggero D, Goodarzi H
Molecular cell 2019 Sep 5;75(5):967-981.e9
Molecular cell 2019 Sep 5;75(5):967-981.e9
Sirtuin 7 promotes 45S pre-rRNA cleavage at site 2 and determines the processing pathway.
Sirri V, Grob A, Berthelet J, Jourdan N, Roussel P
Journal of cell science 2019 Sep 2;132(17)
Journal of cell science 2019 Sep 2;132(17)
MD-2 Homologue Recognizes the White Spot Syndrome Virus Lipid Component and Induces Antiviral Molecule Expression in Shrimp.
Gao J, Wang JX, Wang XW
Journal of immunology (Baltimore, Md. : 1950) 2019 Sep 1;203(5):1131-1141
Journal of immunology (Baltimore, Md. : 1950) 2019 Sep 1;203(5):1131-1141
Naringin mitigates myocardial strain and the inflammatory response in sepsis-induced myocardial dysfunction through regulation of PI3K/AKT/NF-κB pathway.
Sun LJ, Qiao W, Xiao YJ, Cui L, Wang X, Ren WD
International immunopharmacology 2019 Oct;75:105782
International immunopharmacology 2019 Oct;75:105782
MiR-26a promotes fracture healing of nonunion rats possibly by targeting SOSTDC1 and further activating Wnt/β-catenin signaling pathway.
Sun L, Li Z, Xue H, Ma T, Ren C, Li M, Lu Y, Sun H, Zhang K
Molecular and cellular biochemistry 2019 Oct;460(1-2):165-173
Molecular and cellular biochemistry 2019 Oct;460(1-2):165-173
Chrysophanol attenuates airway inflammation and remodeling through nuclear factor-kappa B signaling pathway in asthma.
Song G, Zhang Y, Yu S, Lv W, Guan Z, Sun M, Wang J
Phytotherapy research : PTR 2019 Oct;33(10):2702-2713
Phytotherapy research : PTR 2019 Oct;33(10):2702-2713
Wnt7a, frequently silenced by CpG methylation, inhibits tumor growth and metastasis via suppressing epithelial-mesenchymal transition in gastric cancer.
Liu Y, Qiao Y, Zhang H, Li W, Zheng J
Journal of cellular biochemistry 2019 Oct;120(10):18142-18151
Journal of cellular biochemistry 2019 Oct;120(10):18142-18151
CyclinD1 inhibits dicer and crucial miRNA expression by chromatin modification to promote the progression of intrahepatic cholangiocarcinoma.
Qi Y, Wang D, Huang W, Wang B, Huang D, Xiong F, Chen X, Chen Y
Journal of experimental & clinical cancer research : CR 2019 Oct 7;38(1):413
Journal of experimental & clinical cancer research : CR 2019 Oct 7;38(1):413
The therapeutic effect of verapamil in lipopolysaccharide-induced acute lung injury.
Song Z, Li S, Zhang C, Yuan L, Han L, Liu Y
Biochemical and biophysical research communications 2019 Oct 1;517(4):648-654
Biochemical and biophysical research communications 2019 Oct 1;517(4):648-654
NEDD4 protects vascular endothelial cells against Angiotensin II-induced cell death via enhancement of XPO1-mediated nuclear export.
Xu J, Sheng Z, Li F, Wang S, Yuan Y, Wang M, Yu Z
Experimental cell research 2019 Oct 1;383(1):111505
Experimental cell research 2019 Oct 1;383(1):111505
Trans-cinnamaldehyde improves neuroinflammation-mediated NMDA receptor dysfunction and memory deficits through blocking NF-κB pathway in presenilin1/2 conditional double knockout mice.
Zhao Y, Deng H, Li K, Wang L, Wu Y, Dong X, Wang X, Chen Y, Xu Y
Brain, behavior, and immunity 2019 Nov;82:45-62
Brain, behavior, and immunity 2019 Nov;82:45-62
SIRT4 enhances the sensitivity of ER-positive breast cancer to tamoxifen by inhibiting the IL-6/STAT3 signal pathway.
Xing J, Li J, Fu L, Gai J, Guan J, Li Q
Cancer medicine 2019 Nov;8(16):7086-7097
Cancer medicine 2019 Nov;8(16):7086-7097
Ginkgolide B and bilobalide promote the growth and increase β-catenin expression in hair follicle dermal papilla cells of American minks.
Zhang H, Shi Q, Nan W, Wang Y, Wang S, Yang F, Li G
BioFactors (Oxford, England) 2019 Nov;45(6):950-958
BioFactors (Oxford, England) 2019 Nov;45(6):950-958
PI3K p110α inhibition sensitizes cervical cancer cells with aberrant PI3K signaling activation to PARP inhibitor BMN673.
Cao P, Wang Y, Lv Y, Jiang N, Zhong L, Ma X, Xiao X, Ding D, Gu J, Lin L, Li S
Oncology reports 2019 Nov;42(5):2097-2107
Oncology reports 2019 Nov;42(5):2097-2107
Clematichinenoside Facilitates Recovery of Neurological and Motor Function in Rats after Cerebral Ischemic Injury through Inhibiting Notch/NF-κB Pathway.
Xu D, Xia N, Hou K, Li F, Chen S, Hu Y, Fang W, Li Y
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2019 Nov;28(11):104288
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2019 Nov;28(11):104288
LncRNA HOTAIRM1 promotes osteogenesis by controlling JNK/AP-1 signalling-mediated RUNX2 expression.
Fu L, Peng S, Wu W, Ouyang Y, Tan D, Fu X
Journal of cellular and molecular medicine 2019 Nov;23(11):7517-7524
Journal of cellular and molecular medicine 2019 Nov;23(11):7517-7524
Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus.
Gao P, Chai Y, Song J, Liu T, Chen P, Zhou L, Ge X, Guo X, Han J, Yang H
PLoS pathogens 2019 Nov;15(11):e1008169
PLoS pathogens 2019 Nov;15(11):e1008169
ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex.
Kim W, Zhao F, Wu R, Qin S, Nowsheen S, Huang J, Zhou Q, Chen Y, Deng M, Guo G, Luo K, Lou Z, Yuan J
Nature communications 2019 Nov 22;10(1):5304
Nature communications 2019 Nov 22;10(1):5304
FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival.
Zhou K, Chen H, Lin J, Xu H, Wu H, Bao G, Li J, Deng X, Shui X, Gao W, Ding J, Xiao J, Xu H
Cell death & disease 2019 Nov 18;10(12):872
Cell death & disease 2019 Nov 18;10(12):872
TFEB Mediates Immune Evasion and Resistance to mTOR Inhibition of Renal Cell Carcinoma via Induction of PD-L1.
Zhang C, Duan Y, Xia M, Dong Y, Chen Y, Zheng L, Chai S, Zhang Q, Wei Z, Liu N, Wang J, Sun C, Tang Z, Cheng X, Wu J, Wang G, Zheng F, Laurence A, Li B, Yang XP
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Nov 15;25(22):6827-6838
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Nov 15;25(22):6827-6838
Micro-RNA-27a/b negatively regulates hepatic gluconeogenesis by targeting FOXO1.
Wang S, Ai H, Liu L, Zhang X, Gao F, Zheng L, Yi J, Sun L, Yu C, Zhao H, Li Y
American journal of physiology. Endocrinology and metabolism 2019 Nov 1;317(5):E911-E924
American journal of physiology. Endocrinology and metabolism 2019 Nov 1;317(5):E911-E924
CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression.
Fu XH, Zhang X, Yang H, Xu XW, Hu ZL, Yan J, Zheng XL, Wei RR, Zhang ZQ, Tang SR, Geng MY, Huang X
Acta pharmacologica Sinica 2019 May;40(5):677-688
Acta pharmacologica Sinica 2019 May;40(5):677-688
HepaCAM Regulates Warburg Effect of Renal Cell Carcinoma via HIF-1α/NF-κB Signaling Pathway.
Fan Y, Ou L, Fan J, Li L, Wu X, Luo C, Gao Y, Niu L
Urology 2019 May;127:61-67
Urology 2019 May;127:61-67
Nonmuscle Myosin Heavy Chain IIA Recognizes Sialic Acids on Sialylated RNA Viruses To Suppress Proinflammatory Responses via the DAP12-Syk Pathway.
Liu Y, Li R, Chen XX, Zhi Y, Deng R, Zhou EM, Qiao S, Zhang G
mBio 2019 May 7;10(3)
mBio 2019 May 7;10(3)
Abnormal expression of TBX4 during anorectal development in rat embryos with ethylenethiourea-induced anorectal malformations.
Li M, Zhang H, Liu H, Tian H, Tang X, Bai Y, Wang W
Biological research 2019 May 4;52(1):27
Biological research 2019 May 4;52(1):27
Stella protein facilitates DNA demethylation by disrupting the chromatin association of the RING finger-type E3 ubiquitin ligase UHRF1.
Du W, Dong Q, Zhang Z, Liu B, Zhou T, Xu RM, Wang H, Zhu B, Li Y
The Journal of biological chemistry 2019 May 31;294(22):8907-8917
The Journal of biological chemistry 2019 May 31;294(22):8907-8917
Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway.
Wang H, Wei W, Lan X, Liu N, Li Y, Ma H, Sun T, Peng X, Zhuang C, Yu J
ACS chemical neuroscience 2019 May 15;10(5):2276-2286
ACS chemical neuroscience 2019 May 15;10(5):2276-2286
Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation.
Yang P, Zhou Y, Xia Q, Yao L, Chang X
Biological & pharmaceutical bulletin 2019 May 1;42(5):721-727
Biological & pharmaceutical bulletin 2019 May 1;42(5):721-727
Diminished membrane recruitment of Akt is instrumental in alcohol-associated osteopenia via the PTEN/Akt/GSK-3β/β-catenin axis.
Chen YX, Zhu DY, Gao J, Xu ZL, Tao SC, Yin WJ, Zhang YL, Gao YS, Zhang CQ
The FEBS journal 2019 Mar;286(6):1101-1119
The FEBS journal 2019 Mar;286(6):1101-1119
Blockade of YAP alleviates hepatic fibrosis through accelerating apoptosis and reversion of activated hepatic stellate cells.
Yu HX, Yao Y, Bu FT, Chen Y, Wu YT, Yang Y, Chen X, Zhu Y, Wang Q, Pan XY, Meng XM, Huang C, Li J
Molecular immunology 2019 Mar;107:29-40
Molecular immunology 2019 Mar;107:29-40
The selective HDAC6 inhibitor Nexturastat A induces apoptosis, overcomes drug resistance and inhibits tumor growth in multiple myeloma.
Sun X, Xie Y, Sun X, Yao Y, Li H, Li Z, Yao R, Xu K
Bioscience reports 2019 Mar 29;39(3)
Bioscience reports 2019 Mar 29;39(3)
Suppression of puerarin on polymethylmethacrylate-induced lesion of peri-implant by inhibiting NF-κB activation in vitro and in vivo.
Yan B, Zhou H, Chu J, Cao X
Pathology, research and practice 2019 Jun;215(6):152372
Pathology, research and practice 2019 Jun;215(6):152372
MicroRNA-126 Regulates Angiogenesis and Neurogenesis in a Mouse Model of Focal Cerebral Ischemia.
Qu M, Pan J, Wang L, Zhou P, Song Y, Wang S, Jiang L, Geng J, Zhang Z, Wang Y, Tang Y, Yang GY
Molecular therapy. Nucleic acids 2019 Jun 7;16:15-25
Molecular therapy. Nucleic acids 2019 Jun 7;16:15-25
Tempol alleviates chronic intermittent hypoxia-induced pancreatic injury through repressing inflammation and apoptosis.
Wang Y, Ai L, Hai B, Cao Y, Li R, Li H, Li Y
Physiological research 2019 Jun 30;68(3):445-455
Physiological research 2019 Jun 30;68(3):445-455
Epigenetic suppression of liver X receptor β in anterior cingulate cortex by HDAC5 drives CFA-induced chronic inflammatory pain.
Li YJ, Zhang K, Sun T, Wang J, Guo YY, Yang L, Yang Q, Li YJ, Liu SB, Zhao MG, Wu YM
Journal of neuroinflammation 2019 Jun 29;16(1):132
Journal of neuroinflammation 2019 Jun 29;16(1):132
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
Xu B, Lang LM, Li SZ, Guo JR, Wang JF, Wang D, Zhang LP, Yang HM, Lian S
Cells 2019 Jun 18;8(6)
Cells 2019 Jun 18;8(6)
LXA4 ameliorates cerebrovascular endothelial dysfunction by reducing acute inflammation after subarachnoid hemorrhage in rats.
Liu L, Zhang P, Zhang Z, Hu Q, He J, Liu H, Zhao J, Liang Y, He Z, Li X, Sun X, Guo Z
Neuroscience 2019 Jun 1;408:105-114
Neuroscience 2019 Jun 1;408:105-114
The perforatorium and postacrosomal sheath of rat spermatozoa share common developmental origins and protein constituents†.
Protopapas N, Hamilton LE, Warkentin R, Xu W, Sutovsky P, Oko R
Biology of reproduction 2019 Jun 1;100(6):1461-1472
Biology of reproduction 2019 Jun 1;100(6):1461-1472
Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors.
Wang Y, Zhang J, Ren S, Sun D, Huang HY, Wang H, Jin Y, Li F, Zheng C, Yang L, Deng L, Jiang Z, Jiang T, Han X, Hou S, Guo C, Li F, Gao D, Qin J, Gao D, Chen L, Lin SH, Wong KK, Li C, Hu L, Zhou C, Ji H
Cell reports 2019 Jul 9;28(2):512-525.e6
Cell reports 2019 Jul 9;28(2):512-525.e6
A novel, highly-water-soluble apigenin derivative provides neuroprotection following ischemia in male rats by regulating the ERK/Nrf2/HO-1 pathway.
Zhang S, Xu S, Duan H, Zhu Z, Yang Z, Cao J, Zhao Y, Huang Z, Wu Q, Duan J
European journal of pharmacology 2019 Jul 15;855:208-215
European journal of pharmacology 2019 Jul 15;855:208-215
In the human sperm nucleus, nucleosomes form spatially restricted domains consistent with programmed nucleosome positioning.
Zhang MZ, Cao XM, Xu FQ, Liang XW, Fu LL, Li B, Liu WG, Li SG, Sun FZ, Huang XY, Huang WH
Biology open 2019 Jul 10;8(7)
Biology open 2019 Jul 10;8(7)
OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice.
Yuan C, Guo X, Zhou Q, Du F, Jiang W, Zhou X, Liu P, Chi T, Ji X, Gao J, Chen C, Lang H, Xu J, Liu D, Yang Y, Qiu S, Tang X, Chen G, Zou L
Biochimica et biophysica acta. Molecular basis of disease 2019 Jan;1865(1):161-180
Biochimica et biophysica acta. Molecular basis of disease 2019 Jan;1865(1):161-180
Bclaf1 critically regulates the type I interferon response and is degraded by alphaherpesvirus US3.
Qin C, Zhang R, Lang Y, Shao A, Xu A, Feng W, Han J, Wang M, He W, Yu C, Tang J
PLoS pathogens 2019 Jan;15(1):e1007559
PLoS pathogens 2019 Jan;15(1):e1007559
HSPA12A Is a Novel Player in Nonalcoholic Steatohepatitis via Promoting Nuclear PKM2-Mediated M1 Macrophage Polarization.
Kong Q, Li N, Cheng H, Zhang X, Cao X, Qi T, Dai L, Zhang Z, Chen X, Li C, Li Y, Xue B, Fang L, Liu L, Ding Z
Diabetes 2019 Feb;68(2):361-376
Diabetes 2019 Feb;68(2):361-376
Activation of brain endothelium by Escherichia coli K1 virulence factor cglD promotes polymorphonuclear leukocyte transendothelial migration.
Zhang K, Shi MJ, Niu Z, Chen X, Wei JY, Miao ZW, Zhao WD, Chen YH
Medical microbiology and immunology 2019 Feb;208(1):59-68
Medical microbiology and immunology 2019 Feb;208(1):59-68
CP-25 combined with MTX/ LEF ameliorates the progression of adjuvant-induced arthritis by the inhibition on GRK2 translocation.
Yang X, Zhao Y, Jia X, Wang C, Wu Y, Zhang L, Chang Y, Wei W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Feb;110:834-843
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Feb;110:834-843
Milk fat globule-epidermal growth factor 8 (MFG-E8) attenuates sepsis-induced acute kidney injury by inhibiting NF-κB signaling pathway1.
Zhao Y, Wang Q, Zang B
Acta cirurgica brasileira 2019 Feb 28;34(2):e201900209
Acta cirurgica brasileira 2019 Feb 28;34(2):e201900209
m(6)A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner.
Wu R, Liu Y, Zhao Y, Bi Z, Yao Y, Liu Q, Wang F, Wang Y, Wang X
Cell death & disease 2019 Feb 20;10(3):171
Cell death & disease 2019 Feb 20;10(3):171
Protective effects of a neurokinin 1 receptor antagonist on airway epithelial mitochondria dysfunction in asthmatic mice via Nrf2/HO-1 activation.
Wang Z, Li M, Zhou Q, Shang Y
International immunopharmacology 2019 Dec;77:105952
International immunopharmacology 2019 Dec;77:105952
AZD9291 inactivates the PRC2 complex to mediate tumor growth inhibition.
Zhang KL, Shen QQ, Fang YF, Sun YM, Ding J, Chen Y
Acta pharmacologica Sinica 2019 Dec;40(12):1587-1595
Acta pharmacologica Sinica 2019 Dec;40(12):1587-1595
Peroxisome proliferator-activated receptor gamma participates in the acquisition of brain ischemic tolerance induced by ischemic preconditioning via glial glutamate transporter 1 in vivo and in vitro.
Zhao CC, Jiang MY, Zhang LY, Hu YY, Hu ZJ, Zhang MY, Qi J, Su AC, Lou N, Xian XH, Zhang JG, Li WB, Zhang M
Journal of neurochemistry 2019 Dec;151(5):608-625
Journal of neurochemistry 2019 Dec;151(5):608-625
Endogenous ET-1 promotes ANP secretion through activation of COX2-L-PGDS-PPARγ signaling in hypoxic beating rat atria.
Li X, Han ZN, Liu Y, Hong L, Cui BR, Cui X
Peptides 2019 Dec;122:170150
Peptides 2019 Dec;122:170150
Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer.
Yang L, Lei Q, Li L, Yang J, Dong Z, Cui H
Clinical epigenetics 2019 Dec 30;11(1):199
Clinical epigenetics 2019 Dec 30;11(1):199
Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis.
Huang X, Ni B, Xi Y, Chu X, Zhang R, You H
Aging 2019 Dec 16;11(24):12532-12545
Aging 2019 Dec 16;11(24):12532-12545
Bilirubin alleviates alum-induced peritonitis through inactivation of NLRP3 inflammasome.
Lin Y, Wang S, Yang Z, Gao L, Zhou Z, Yu P, Wu B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Aug;116:108973
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Aug;116:108973
TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells.
He R, Wang M, Zhao C, Shen M, Yu Y, He L, Zhao Y, Chen H, Shi X, Zhou M, Pan S, Liu Y, Guo X, Li X, Qin R
Journal of experimental & clinical cancer research : CR 2019 Aug 6;38(1):340
Journal of experimental & clinical cancer research : CR 2019 Aug 6;38(1):340
Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure.
Xu B, Lang LM, Li SZ, Guo JR, Wang JF, Yang HM, Lian S
Biomolecules 2019 Aug 30;9(9)
Biomolecules 2019 Aug 30;9(9)
Calcium-sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor-β signaling to promote breast cancer metastasis.
Miao Y, Shen Q, Zhang S, Huang H, Meng X, Zheng X, Yao Z, He Z, Lu S, Cai C, Zou F
Breast cancer research : BCR 2019 Aug 29;21(1):99
Breast cancer research : BCR 2019 Aug 29;21(1):99
PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis.
Jiang Y, Liu F, Zou F, Zhang Y, Wang B, Zhang Y, Lian A, Han X, Liu Z, Liu X, Jin M, Wang D, Li G, Liu J
Stem cell research & therapy 2019 Aug 23;10(1):268
Stem cell research & therapy 2019 Aug 23;10(1):268
KMT2D deficiency enhances the anti-cancer activity of L48H37 in pancreatic ductal adenocarcinoma.
Li SS, Jiang WL, Xiao WQ, Li K, Zhang YF, Guo XY, Dai YQ, Zhao QY, Jiang MJ, Lu ZJ, Wan R
World journal of gastrointestinal oncology 2019 Aug 15;11(8):599-621
World journal of gastrointestinal oncology 2019 Aug 15;11(8):599-621
HO-1 reduces heat stress-induced apoptosis in bovine granulosa cells by suppressing oxidative stress.
Wang Y, Yang C, Elsheikh NAH, Li C, Yang F, Wang G, Li L
Aging 2019 Aug 12;11(15):5535-5547
Aging 2019 Aug 12;11(15):5535-5547
Regulation of position effect variegation at pericentric heterochromatin by Drosophila Keap1-Nrf2 xenobiotic response factors.
Carlson J, Swisse T, Smith C, Deng H
Genesis (New York, N.Y. : 2000) 2019 Apr;57(4):e23290
Genesis (New York, N.Y. : 2000) 2019 Apr;57(4):e23290
Knockdown of cathepsin D protects dopaminergic neurons against neuroinflammation-mediated neurotoxicity through inhibition of NF-κB signalling pathway in Parkinson's disease model.
Gan P, Xia Q, Hang G, Zhou Y, Qian X, Wang X, Ding L
Clinical and experimental pharmacology & physiology 2019 Apr;46(4):337-349
Clinical and experimental pharmacology & physiology 2019 Apr;46(4):337-349
SRT1720 retards renal fibrosis via inhibition of HIF1A/GLUT1 in diabetic nephropathy.
Han W, Wang C, Yang Z, Mu L, Wu M, Chen N, Du C, Duan H, Shi Y
The Journal of endocrinology 2019 Apr;241(1):85-98
The Journal of endocrinology 2019 Apr;241(1):85-98
5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress.
Xu LL, Wu YF, Yan F, Li CC, Dai Z, You QD, Jiang ZY, Di B
Free radical biology & medicine 2019 Apr;134:288-303
Free radical biology & medicine 2019 Apr;134:288-303
Stabilized Peptide HDAC Inhibitors Derived from HDAC1 Substrate H3K56 for the Treatment of Cancer Stem-Like Cells In Vivo.
Wang D, Li W, Zhao R, Chen L, Liu N, Tian Y, Zhao H, Xie M, Lu F, Fang Q, Liang W, Yin F, Li Z
Cancer research 2019 Apr 15;79(8):1769-1783
Cancer research 2019 Apr 15;79(8):1769-1783
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Huang Y, Su R, Sheng Y, Dong L, Dong Z, Xu H, Ni T, Zhang ZS, Zhang T, Li C, Han L, Zhu Z, Lian F, Wei J, Deng Q, Wang Y, Wunderlich M, Gao Z, Pan G, Zhong D, Zhou H, Zhang N, Gan J, Jiang H, Mulloy JC, Qian Z, Chen J, Yang CG
Cancer cell 2019 Apr 15;35(4):677-691.e10
Cancer cell 2019 Apr 15;35(4):677-691.e10
Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF-κB signaling pathway in a mouse model of Parkinson's disease.
Lv R, Du L, Liu X, Zhou F, Zhang Z, Zhang L
Life sciences 2019 Apr 15;223:158-165
Life sciences 2019 Apr 15;223:158-165
miR-203 Inhibits Alcohol-Induced Hepatic Steatosis by Targeting Lipin1.
Cheng XY, Liu JD, Lu XY, Yan X, Huang C, Meng XM, Li J
Frontiers in pharmacology 2018;9:275
Frontiers in pharmacology 2018;9:275
Aryl hydrocarbon receptor activated by benzo (a) pyrene promotes SMARCA6 expression in NSCLC.
Mao C, Wang M, Qian B, Ouyang L, Shi Y, Liu N, Chen L, Xiao D, Wang X, Cao Y, Liu S, Tao Y, Liu W
American journal of cancer research 2018;8(7):1214-1227
American journal of cancer research 2018;8(7):1214-1227
Adipocytes fuel gastric cancer omental metastasis via PITPNC1-mediated fatty acid metabolic reprogramming.
Tan Y, Lin K, Zhao Y, Wu Q, Chen D, Wang J, Liang Y, Li J, Hu J, Wang H, Liu Y, Zhang S, He W, Huang Q, Hu X, Yao Z, Liang B, Liao W, Shi M
Theranostics 2018;8(19):5452-5468
Theranostics 2018;8(19):5452-5468
Flavonoid-Rich Ethanol Extract from the Leaves of Diospyros kaki Attenuates D-Galactose-Induced Oxidative Stress and Neuroinflammation-Mediated Brain Aging in Mice.
Ma Y, Ma B, Shang Y, Yin Q, Wang D, Xu S, Hong Y, Hou X, Liu X
Oxidative medicine and cellular longevity 2018;2018:8938207
Oxidative medicine and cellular longevity 2018;2018:8938207
3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation.
Xu LL, Liu T, Wang L, Li L, Wu YF, Li CC, Di B, You QD, Jiang ZY
Oxidative medicine and cellular longevity 2018;2018:3271617
Oxidative medicine and cellular longevity 2018;2018:3271617
Lithium chloride inhibits cell survival, overcomes drug resistance, and triggers apoptosis in multiple myeloma via activation of the Wnt/β-catenin pathway.
Yao R, Sun X, Xie Y, Liu L, Han D, Yao Y, Li H, Li Z, Xu K
American journal of translational research 2018;10(8):2610-2618
American journal of translational research 2018;10(8):2610-2618
Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.
Li Y, Qian W, Wang D, Meng Y, Wang X, Chen Y, Li X, Xie C, Zhong C, Fu S
Journal of applied toxicology : JAT 2018 Sep;38(9):1251-1261
Journal of applied toxicology : JAT 2018 Sep;38(9):1251-1261
Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury.
He J, Liu H, Zhong J, Guo Z, Wu J, Zhang H, Huang Z, Jiang L, Li H, Zhang Z, Liu L, Wu Y, Qi L, Sun X, Cheng C
Neurobiology of disease 2018 Sep;117:114-124
Neurobiology of disease 2018 Sep;117:114-124
Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors.
Huang X, Yan J, Zhang M, Wang Y, Chen Y, Fu X, Wei R, Zheng XL, Liu Z, Zhang X, Yang H, Hao B, Shen YY, Su Y, Cong X, Huang M, Tan M, Ding J, Geng M
Cell 2018 Sep 20;175(1):186-199.e19
Cell 2018 Sep 20;175(1):186-199.e19
XPO1-mediated nuclear export of RNF146 protects from angiotensin II-induced endothelial cellular injury.
Sheng Z, Xu Y, Wang S, Yuan Y, Huang T, Lu P
Biochemical and biophysical research communications 2018 Sep 10;503(3):1544-1549
Biochemical and biophysical research communications 2018 Sep 10;503(3):1544-1549
REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis.
Wang S, Lin Y, Yuan X, Li F, Guo L, Wu B
Nature communications 2018 Oct 12;9(1):4246
Nature communications 2018 Oct 12;9(1):4246
Isopsoralen Enhanced Osteogenesis by Targeting AhR/ERα.
Ge L, Cui Y, Cheng K, Han J
Molecules (Basel, Switzerland) 2018 Oct 11;23(10)
Molecules (Basel, Switzerland) 2018 Oct 11;23(10)
BRMS1L suppresses ovarian cancer metastasis via inhibition of the β-catenin-wnt pathway.
Cao P, Zhao S, Sun Z, Jiang N, Shang Y, Wang Y, Gu J, Li S
Experimental cell research 2018 Oct 1;371(1):214-221
Experimental cell research 2018 Oct 1;371(1):214-221
Regulation of osteogenesis by micro/nano hierarchical titanium surfaces through a Rock-Wnt5a feedback loop.
Yu Y, Shen X, Liu J, Hu Y, Ran Q, Mu C, Cai K
Colloids and surfaces. B, Biointerfaces 2018 Oct 1;170:1-10
Colloids and surfaces. B, Biointerfaces 2018 Oct 1;170:1-10
Inhibition of microRNA-143-3p attenuates myocardial hypertrophy by inhibiting inflammatory response.
Yu B, Zhao Y, Zhang H, Xie D, Nie W, Shi K
Cell biology international 2018 Nov;42(11):1584-1593
Cell biology international 2018 Nov;42(11):1584-1593
Citrus Tangeretin Improves Skeletal Muscle Mitochondrial Biogenesis via Activating the AMPK-PGC1-α Pathway In Vitro and In Vivo: A Possible Mechanism for Its Beneficial Effect on Physical Performance.
Kou G, Li Z, Wu C, Liu Y, Hu Y, Guo L, Xu X, Zhou Z
Journal of agricultural and food chemistry 2018 Nov 14;66(45):11917-11925
Journal of agricultural and food chemistry 2018 Nov 14;66(45):11917-11925
Small molecules capable of activating DNA methylation-repressed genes targeted by the p38 mitogen-activated protein kinase pathway.
Li X, Shang E, Dong Q, Li Y, Zhang J, Xu S, Zhao Z, Shao W, Lv C, Zheng Y, Wang H, Lei X, Zhu B, Zhang Z
The Journal of biological chemistry 2018 May 11;293(19):7423-7436
The Journal of biological chemistry 2018 May 11;293(19):7423-7436
Mitotic Phosphorylation of SENP3 Regulates DeSUMOylation of Chromosome-Associated Proteins and Chromosome Stability.
Wei B, Huang C, Liu B, Wang Y, Xia N, Fan Q, Chen GQ, Cheng J
Cancer research 2018 May 1;78(9):2171-2178
Cancer research 2018 May 1;78(9):2171-2178
Sphingosine-1-phosphate ameliorates the cardiac hypertrophic response through inhibiting the activity of histone deacetylase-2.
Yan H, Yi S, Zhuang H, Wu L, Wang DW, Jiang J
International journal of molecular medicine 2018 Mar;41(3):1704-1714
International journal of molecular medicine 2018 Mar;41(3):1704-1714
Key Role of TFEB Nucleus Translocation for Silver Nanoparticle-Induced Cytoprotective Autophagy.
Lin J, Liu Y, Wu H, Huang Z, Ma J, Guo C, Gao F, Jin P, Wei P, Zhang Y, Liu L, Zhang R, Qiu L, Gu N, Wen L
Small (Weinheim an der Bergstrasse, Germany) 2018 Mar;14(13):e1703711
Small (Weinheim an der Bergstrasse, Germany) 2018 Mar;14(13):e1703711
The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1.
Zhao Y, Liu Y, Lin L, Huang Q, He W, Zhang S, Dong S, Wen Z, Rao J, Liao W, Shi M
Molecular cancer 2018 Mar 6;17(1):69
Molecular cancer 2018 Mar 6;17(1):69
JMJD3 is involved in neutrophil membrane proteinase 3 overexpression during the hyperinflammatory response in early sepsis.
Chen Y, Liu Z, Pan T, Chen E, Mao E, Chen Y, Tan R, Wang X, Tian R, Liu J, Qu H
International immunopharmacology 2018 Jun;59:40-46
International immunopharmacology 2018 Jun;59:40-46
Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.
He W, Ye S, Zeng C, Xue S, Hu X, Zhang X, Gao S, Xiong Y, He X, Vivalda S, Li L, Wang Y, Ye Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 5;:fj201800028RR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 5;:fj201800028RR
Integrin αvβ3-associated DAAM1 is essential for collagen-induced invadopodia extension and cell haptotaxis in breast cancer cells.
Yan T, Zhang A, Shi F, Chang F, Mei J, Liu Y, Zhu Y
The Journal of biological chemistry 2018 Jun 29;293(26):10172-10185
The Journal of biological chemistry 2018 Jun 29;293(26):10172-10185
The histone methyltransferase SETD2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice.
Zuo X, Rong B, Li L, Lv R, Lan F, Tong MH
The Journal of biological chemistry 2018 Jun 15;293(24):9188-9197
The Journal of biological chemistry 2018 Jun 15;293(24):9188-9197
The Role of the RhoA/ROCK Signaling Pathway in Mechanical Strain-Induced Scleral Myofibroblast Differentiation.
Yuan Y, Li M, To CH, Lam TC, Wang P, Yu Y, Chen Q, Hu X, Ke B
Investigative ophthalmology & visual science 2018 Jul 2;59(8):3619-3629
Investigative ophthalmology & visual science 2018 Jul 2;59(8):3619-3629
Ubiquitin-Specific Protease USP6 Regulates the Stability of the c-Jun Protein.
Li L, Yang H, He Y, Li T, Feng J, Chen W, Ao L, Shi X, Lin Y, Liu H, Zheng E, Lin Q, Bu J, Zeng Y, Zheng M, Xu Y, Liao Z, Lin J, Lin D
Molecular and cellular biology 2018 Jan 15;38(2)
Molecular and cellular biology 2018 Jan 15;38(2)
6-Hydroxydopamine induces autophagic flux dysfunction by impairing transcription factor EB activation and lysosomal function in dopaminergic neurons and SH-SY5Y cells.
He X, Yuan W, Li Z, Hou Y, Liu F, Feng J
Toxicology letters 2018 Feb;283:58-68
Toxicology letters 2018 Feb;283:58-68
CDK5-mediated phosphorylation of Sirt2 contributes to depressive-like behavior induced by social defeat stress.
Zhang Z, Zhang P, Qi GJ, Jiao FJ, Wang QZ, Yan JG, He F, Zhang Q, Lv ZX, Peng X, Cai HW, Chen X, Sun N, Tian B
Biochimica et biophysica acta. Molecular basis of disease 2018 Feb;1864(2):533-541
Biochimica et biophysica acta. Molecular basis of disease 2018 Feb;1864(2):533-541
Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway.
Yuan G, Chen X, Liu Z, Wei W, Shu Q, Abou-Hamdan H, Jiang L, Li X, Chen R, Désaubry L, Zhou F, Xie D
Journal of experimental & clinical cancer research : CR 2018 Feb 7;37(1):21
Journal of experimental & clinical cancer research : CR 2018 Feb 7;37(1):21
Yes-Associated Protein Promotes Angiogenesis via Signal Transducer and Activator of Transcription 3 in Endothelial Cells.
He J, Bao Q, Zhang Y, Liu M, Lv H, Liu Y, Yao L, Li B, Zhang C, He S, Zhai G, Zhu Y, Liu X, Zhang K, Wang XJ, Zou MH, Zhu Y, Ai D
Circulation research 2018 Feb 16;122(4):591-605
Circulation research 2018 Feb 16;122(4):591-605
Modulation of autophagy in the protective effect of resveratrol on PM2.5-induced pulmonary oxidative injury in mice.
Li Y, Fu S, Li E, Sun X, Xu H, Meng Y, Wang X, Chen Y, Xie C, Geng S, Wu J, Zhong C, Xu P
Phytotherapy research : PTR 2018 Dec;32(12):2480-2486
Phytotherapy research : PTR 2018 Dec;32(12):2480-2486
Tempol relieves lung injury in a rat model of chronic intermittent hypoxia via suppression of inflammation and oxidative stress.
Wang Y, Hai B, Ai L, Cao Y, Li R, Li H, Li Y
Iranian journal of basic medical sciences 2018 Dec;21(12):1238-1244
Iranian journal of basic medical sciences 2018 Dec;21(12):1238-1244
DNase-1 Treatment Exerts Protective Effects in a Rat Model of Intestinal Ischemia-Reperfusion Injury.
Wang S, Xie T, Sun S, Wang K, Liu B, Wu X, Ding W
Scientific reports 2018 Dec 12;8(1):17788
Scientific reports 2018 Dec 12;8(1):17788
Anticancer effect of histone deacetylase inhibitor scriptaid as a single agent for hepatocellular carcinoma.
Liu L, Sun X, Xie Y, Zhuang Y, Yao R, Xu K
Bioscience reports 2018 Aug 31;38(4)
Bioscience reports 2018 Aug 31;38(4)
Thymol alleviates lipopolysaccharide-stimulated inflammatory response via downregulation of RhoA-mediated NF-κB signalling pathway in human peritoneal mesothelial cells.
Wang Q, Cheng F, Xu Y, Zhang J, Qi J, Liu X, Wang R
European journal of pharmacology 2018 Aug 15;833:210-220
European journal of pharmacology 2018 Aug 15;833:210-220
Role of Peroxiredoxin 2 in the Protection Against Ferrous Sulfate-Induced Oxidative and Inflammatory Injury in PC12 Cells.
Xu W, Li F, Xu Z, Sun B, Cao J, Liu Y
Cellular and molecular neurobiology 2018 Apr;38(3):735-745
Cellular and molecular neurobiology 2018 Apr;38(3):735-745
27-Hydroxycholesterol Inhibits Sterol Regulatory Element-Binding Protein 1 Activation and Hepatic Lipid Accumulation in Mice.
Li D, Long W, Huang R, Chen Y, Xia M
Obesity (Silver Spring, Md.) 2018 Apr;26(4):713-722
Obesity (Silver Spring, Md.) 2018 Apr;26(4):713-722
Anti-Proliferative Activity of HPOB against Multiple Myeloma Cells via p21 Transcriptional Activation.
Liu L, Sun X, Xie Y, Zhuang Y, Yao R, Xu K
Molecules (Basel, Switzerland) 2018 Apr 30;23(5)
Molecules (Basel, Switzerland) 2018 Apr 30;23(5)
Neurochondrin interacts with the SMN protein suggesting a novel mechanism for spinal muscular atrophy pathology.
Thompson LW, Morrison KD, Shirran SL, Groen EJN, Gillingwater TH, Botting CH, Sleeman JE
Journal of cell science 2018 Apr 17;131(8)
Journal of cell science 2018 Apr 17;131(8)
Epstein-Barr Virus miR-BART6-3p Inhibits the RIG-I Pathway.
Lu Y, Qin Z, Wang J, Zheng X, Lu J, Zhang X, Wei L, Peng Q, Zheng Y, Ou C, Ye Q, Xiong W, Li G, Fu Y, Yan Q, Ma J
Journal of innate immunity 2017;9(6):574-586
Journal of innate immunity 2017;9(6):574-586
EGFRwt/vIII-PKM2-β-catenin cascade affects proliferation and chemo-sensitivity in head and neck squamous cell carcinoma.
Jing C, Qu X, Li Z, Wu C, Zhao M, Wang Y, Sun S, Zhang S, Chen J, Qiao Y, Hu X, Yao X, Jin R, Wang X, Zhang L, Zhou X
American journal of cancer research 2017;7(12):2491-2502
American journal of cancer research 2017;7(12):2491-2502
trans-Cinnamaldehyde Inhibits Microglial Activation and Improves Neuronal Survival against Neuroinflammation in BV2 Microglial Cells with Lipopolysaccharide Stimulation.
Fu Y, Yang P, Zhao Y, Zhang L, Zhang Z, Dong X, Wu Z, Xu Y, Chen Y
Evidence-based complementary and alternative medicine : eCAM 2017;2017:4730878
Evidence-based complementary and alternative medicine : eCAM 2017;2017:4730878
Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis.
Zhao Z, Zhang L, Guo XD, Cao LL, Xue TF, Zhao XJ, Yang DD, Yang J, Ji J, Huang JY, Sun XL
Frontiers in molecular neuroscience 2017;10:293
Frontiers in molecular neuroscience 2017;10:293
TSPAN31 is a critical regulator on transduction of survival and apoptotic signals in hepatocellular carcinoma cells.
Wang J, Zhou Y, Li D, Sun X, Deng Y, Zhao Q
FEBS letters 2017 Sep;591(18):2905-2918
FEBS letters 2017 Sep;591(18):2905-2918
MicroRNA-27b inhibition promotes Nrf2/ARE pathway activation and alleviates intracerebral hemorrhage-induced brain injury.
Xu W, Li F, Liu Z, Xu Z, Sun B, Cao J, Liu Y
Oncotarget 2017 Sep 19;8(41):70669-70684
Oncotarget 2017 Sep 19;8(41):70669-70684
An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.
Liu J, Wang L, Du Y, Liu S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2017 Oct;4(10):1700089
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2017 Oct;4(10):1700089
Triptolide induces DNA breaks, activates caspase-3-dependent apoptosis and sensitizes B-cell lymphoma to poly(ADP-ribose) polymerase 1 and phosphoinositide 3-kinase inhibitors.
Guan J, Zhao Q, Lv J, Zhang Z, Sun S, Mao W
Oncology letters 2017 Oct;14(4):4965-4970
Oncology letters 2017 Oct;14(4):4965-4970
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathway.
Yan S, Wei X, Xu S, Sun H, Wang W, Liu L, Jiang X, Zhang Y, Che Y
Oncotarget 2017 Oct 6;8(46):80909-80922
Oncotarget 2017 Oct 6;8(46):80909-80922
Involvement of aberrantly activated HOTAIR/EZH2/miR-193a feedback loop in progression of prostate cancer.
Ling Z, Wang X, Tao T, Zhang L, Guan H, You Z, Lu K, Zhang G, Chen S, Wu J, Qian J, Liu H, Xu B, Chen M
Journal of experimental & clinical cancer research : CR 2017 Nov 15;36(1):159
Journal of experimental & clinical cancer research : CR 2017 Nov 15;36(1):159
YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63-GPX2 Axis and ROS Accumulation.
Huang H, Zhang W, Pan Y, Gao Y, Deng L, Li F, Li F, Ma X, Hou S, Xu J, Li P, Li X, Hu G, Li C, Chen H, Zhang L, Ji H
Cancer research 2017 Nov 1;77(21):5769-5781
Cancer research 2017 Nov 1;77(21):5769-5781
Shp2 promotes liver cancer stem cell expansion by augmenting β-catenin signaling and predicts chemotherapeutic response of patients.
Xiang D, Cheng Z, Liu H, Wang X, Han T, Sun W, Li X, Yang W, Chen C, Xia M, Liu N, Yin S, Jin G, Lee T, Dong L, Hu H, Wang H, Ding J
Hepatology (Baltimore, Md.) 2017 May;65(5):1566-1580
Hepatology (Baltimore, Md.) 2017 May;65(5):1566-1580
Hypoxia induces oncogene yes-associated protein 1 nuclear translocation to promote pancreatic ductal adenocarcinoma invasion via epithelial-mesenchymal transition.
Wei H, Xu Z, Liu F, Wang F, Wang X, Sun X, Li J
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 May;39(5):1010428317691684
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 May;39(5):1010428317691684
Early-Life Social Isolation-Induced Depressive-Like Behavior in Rats Results in Microglial Activation and Neuronal Histone Methylation that Are Mitigated by Minocycline.
Wang HT, Huang FL, Hu ZL, Zhang WJ, Qiao XQ, Huang YQ, Dai RP, Li F, Li CQ
Neurotoxicity research 2017 May;31(4):505-520
Neurotoxicity research 2017 May;31(4):505-520
Aspirin suppresses the abnormal lipid metabolism in liver cancer cells via disrupting an NFκB-ACSL1 signaling.
Yang G, Wang Y, Feng J, Liu Y, Wang T, Zhao M, Ye L, Zhang X
Biochemical and biophysical research communications 2017 May 6;486(3):827-832
Biochemical and biophysical research communications 2017 May 6;486(3):827-832
miR-181a-5p, an inducer of Wnt-signaling, facilitates cell proliferation in acute lymphoblastic leukemia.
Lyu X, Li J, Yun X, Huang R, Deng X, Wang Y, Chen Y, Xiao G
Oncology reports 2017 Mar;37(3):1469-1476
Oncology reports 2017 Mar;37(3):1469-1476
BTP2, a Store-Operated Calcium Channel Inhibitor, Attenuates Lung Ischemia-Reperfusion Injury in Rats.
Zhang W, Qi Z, Wang Y
Inflammation 2017 Jun;40(3):778-787
Inflammation 2017 Jun;40(3):778-787
Long noncoding RNA CRNDE stabilized by hnRNPUL2 accelerates cell proliferation and migration in colorectal carcinoma via activating Ras/MAPK signaling pathways.
Jiang H, Wang Y, Ai M, Wang H, Duan Z, Wang H, Zhao L, Yu J, Ding Y, Wang S
Cell death & disease 2017 Jun 8;8(6):e2862
Cell death & disease 2017 Jun 8;8(6):e2862
RACK1 promotes lung cancer cell growth via an MCM7/RACK1/ Akt signaling complex.
Fei L, Ma Y, Zhang M, Liu X, Luo Y, Wang C, Zhang H, Zhang W, Han Y
Oncotarget 2017 Jun 20;8(25):40501-40513
Oncotarget 2017 Jun 20;8(25):40501-40513
Quinocetone induces mitochondrial apoptosis in HepG2 cells through ROS-dependent promotion of VDAC1 oligomerization and suppression of Wnt1/β-catenin signaling pathway.
Yang X, Tang S, Dai C, Li D, Zhang S, Deng S, Zhou Y, Xiao X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Jul;105:161-176
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Jul;105:161-176
CDK5-mediated phosphorylation of XBP1s contributes to its nuclear translocation and activation in MPP(+)-induced Parkinson's disease model.
Jiao FJ, Wang QZ, Zhang P, Yan JG, Zhang Z, He F, Zhang Q, Lv ZX, Peng X, Cai HW, Tian B
Scientific reports 2017 Jul 17;7(1):5622
Scientific reports 2017 Jul 17;7(1):5622
Dicer promotes tumorigenesis by translocating to nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells.
Cheng W, Qi Y, Tian L, Wang B, Huang W, Chen Y
Cell death & disease 2017 Feb 23;8(2):e2628
Cell death & disease 2017 Feb 23;8(2):e2628
Rabphilin 3A: A novel target for the treatment of levodopa-induced dyskinesias.
Stanic J, Mellone M, Napolitano F, Racca C, Zianni E, Minocci D, Ghiglieri V, Thiolat ML, Li Q, Longhi A, De Rosa A, Picconi B, Bezard E, Calabresi P, Di Luca M, Usiello A, Gardoni F
Neurobiology of disease 2017 Dec;108:54-64
Neurobiology of disease 2017 Dec;108:54-64
Kaiso protects human umbilical vein endothelial cells against apoptosis by differentially regulating the expression of B-cell CLL/lymphoma 2 family members.
Xue X, Zhang J, Lan H, Xu Y, Wang H
Scientific reports 2017 Aug 2;7(1):7116
Scientific reports 2017 Aug 2;7(1):7116
Tert-butylhydroquinone protects PC12 cells against ferrous sulfate-induced oxidative and inflammatory injury via the Nrf2/ARE pathway.
Xu W, Li F, Xu Z, Sun B, Cao J, Liu Y
Chemico-biological interactions 2017 Aug 1;273:28-36
Chemico-biological interactions 2017 Aug 1;273:28-36
Targeting NF-kB signaling with polymeric hybrid micelles that co-deliver siRNA and dexamethasone for arthritis therapy.
Wang Q, Jiang H, Li Y, Chen W, Li H, Peng K, Zhang Z, Sun X
Biomaterials 2017 Apr;122:10-22
Biomaterials 2017 Apr;122:10-22
Transcription factors regulate GPR91-mediated expression of VEGF in hypoxia-induced retinopathy.
Li T, Hu J, Gao F, Du X, Chen Y, Wu Q
Scientific reports 2017 Apr 4;7:45807
Scientific reports 2017 Apr 4;7:45807
Loss of Polycomb Group Protein Pcgf1 Severely Compromises Proper Differentiation of Embryonic Stem Cells.
Yan Y, Zhao W, Huang Y, Tong H, Xia Y, Jiang Q, Qin J
Scientific reports 2017 Apr 10;7:46276
Scientific reports 2017 Apr 10;7:46276
Daphnetin Protects against Cerebral Ischemia/Reperfusion Injury in Mice via Inhibition of TLR4/NF-κB Signaling Pathway.
Liu J, Chen Q, Jian Z, Xiong X, Shao L, Jin T, Zhu X, Wang L
BioMed research international 2016;2016:2816056
BioMed research international 2016;2016:2816056
Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.
Gao Z, Han Y, Hu Y, Wu X, Wang Y, Zhang X, Fu J, Zou X, Zhang J, Chen X, Jose PA, Lu X, Zeng C
PloS one 2016;11(2):e0149032
PloS one 2016;11(2):e0149032
Compositional Analysis of Asymmetric and Symmetric Dimethylated H3R2 Using Liquid Chromatography-Tandem Mass Spectrometry-Based Targeted Proteomics.
Xu Q, Xu F, Liu L, Chen Y
Analytical chemistry 2016 Sep 6;88(17):8441-9
Analytical chemistry 2016 Sep 6;88(17):8441-9
Anticancer effect of SZC015 on lung cancer cells through ROS-dependent apoptosis and autophagy induction mechanisms in vitro.
Sun B, Gao L, Ahsan A, Chu P, Song Y, Li H, Zhang Z, Lin Y, Peng J, Song Z, Wang S, Tang Z
International immunopharmacology 2016 Nov;40:400-409
International immunopharmacology 2016 Nov;40:400-409
Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents.
Zhang PY, Li G, Deng ZJ, Liu LY, Chen L, Tang JZ, Wang YQ, Cao ST, Fang YX, Wen F, Xu Y, Chen X, Shi KQ, Li WF, Xie C, Tang KF
Nucleic acids research 2016 May 5;44(8):3629-42
Nucleic acids research 2016 May 5;44(8):3629-42
S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
Jayaram H, Hoelper D, Jain SU, Cantone N, Lundgren SM, Poy F, Allis CD, Cummings R, Bellon S, Lewis PW
Proceedings of the National Academy of Sciences of the United States of America 2016 May 31;113(22):6182-7
Proceedings of the National Academy of Sciences of the United States of America 2016 May 31;113(22):6182-7
TGF-β1 activates the canonical NF-κB signaling to promote cell survival and proliferation in dystrophic muscle fibroblasts in vitro.
Ma ZY, Zhong ZG, Qiu MY, Zhong YH, Zhang WX
Biochemical and biophysical research communications 2016 Mar 18;471(4):576-81
Biochemical and biophysical research communications 2016 Mar 18;471(4):576-81
Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus.
Dinamarca MC, Guzzetti F, Karpova A, Lim D, Mitro N, Musardo S, Mellone M, Marcello E, Stanic J, Samaddar T, Burguière A, Caldarelli A, Genazzani AA, Perroy J, Fagni L, Canonico PL, Kreutz MR, Gardoni F, Di Luca M
eLife 2016 Mar 15;5:e12430
eLife 2016 Mar 15;5:e12430
New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.
Ding C, Zhao Y, Shi X, Zhang N, Zu G, Li Z, Zhou J, Gao D, Lv L, Tian X, Yao J
Scientific reports 2016 Jun 27;6:28734
Scientific reports 2016 Jun 27;6:28734
HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis.
Chen Y, Pan K, Wang P, Cao Z, Wang W, Wang S, Hu N, Xue J, Li H, Jiang W, Li G, Zhang X
The Journal of biological chemistry 2016 Jun 10;291(24):12688-12705
The Journal of biological chemistry 2016 Jun 10;291(24):12688-12705
Downregulation of HP1α suppresses proliferation of cholangiocarcinoma by restoring SFRP1 expression.
Cheng W, Tian L, Wang B, Qi Y, Huang W, Li H, Chen YJ
Oncotarget 2016 Jul 26;7(30):48107-48119
Oncotarget 2016 Jul 26;7(30):48107-48119
Downregulation of vimentin expression increased drug resistance in ovarian cancer cells.
Huo Y, Zheng Z, Chen Y, Wang Q, Zhang Z, Deng H
Oncotarget 2016 Jul 19;7(29):45876-45888
Oncotarget 2016 Jul 19;7(29):45876-45888
Downregulation of ACE2/Ang-(1-7)/Mas axis promotes breast cancer metastasis by enhancing store-operated calcium entry.
Yu C, Tang W, Wang Y, Shen Q, Wang B, Cai C, Meng X, Zou F
Cancer letters 2016 Jul 1;376(2):268-77
Cancer letters 2016 Jul 1;376(2):268-77
SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
Wu J, Yang C, Guo C, Li X, Yang N, Zhao L, Hang H, Liu S, Chu P, Sun Z, Sun B, Lin Y, Peng J, Han G, Wang S, Tang Z
Chemico-biological interactions 2016 Jan 25;244:94-104
Chemico-biological interactions 2016 Jan 25;244:94-104
IL-17 intensifies IFN-γ-induced NOS2 upregulation in RAW 264.7 cells by further activating STAT1 and NF-κB.
Gao Q, Liu Y, Wu Y, Zhao Q, Wang L, Gao S, Wen W, Zhang W, Guo N, Zhou J, Yuan Z
International journal of molecular medicine 2016 Feb;37(2):347-58
International journal of molecular medicine 2016 Feb;37(2):347-58
Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells.
Gao L, Xu Z, Wang Y, Sun B, Song Z, Yang B, Liu X, Lin Y, Peng J, Han G, Wang S, Tang Z
Oncology reports 2016 Feb;35(2):1101-8
Oncology reports 2016 Feb;35(2):1101-8
The HIF/PHF8/AR axis promotes prostate cancer progression.
Tong D, Liu Q, Liu G, Yuan W, Wang L, Guo Y, Lan W, Zhang D, Dong S, Wang Y, Xiao H, Mu J, Mao C, Wong J, Jiang J
Oncogenesis 2016 Dec 19;5(12):e283
Oncogenesis 2016 Dec 19;5(12):e283
Genetic variants in microRNAs predict non-small cell lung cancer prognosis in Chinese female population in a prospective cohort study.
Lingzi X, Zhihua Y, Xuelian L, Yangwu R, Haibo Z, Yuxia Z, Baosen Z
Oncotarget 2016 Dec 13;7(50):83101-83114
Oncotarget 2016 Dec 13;7(50):83101-83114
Molecular similarity guided optimization of novel Nrf2 activators with 1,2,4-oxadiazole core.
Xu LL, Zhang X, Jiang ZY, You QD
Bioorganic & medicinal chemistry 2016 Aug 15;24(16):3540-7
Bioorganic & medicinal chemistry 2016 Aug 15;24(16):3540-7
Early ketamine exposure results in cardiac enlargement and heart dysfunction in Xenopus embryos.
Guo R, Liu G, Du M, Shi Y, Jiang P, Liu X, Liu L, Liu J, Xu Y
BMC anesthesiology 2016 Apr 18;16:23
BMC anesthesiology 2016 Apr 18;16:23
FUS Interacts with HSP60 to Promote Mitochondrial Damage.
Deng J, Yang M, Chen Y, Chen X, Liu J, Sun S, Cheng H, Li Y, Bigio EH, Mesulam M, Xu Q, Du S, Fushimi K, Zhu L, Wu JY
PLoS genetics 2015 Sep;11(9):e1005357
PLoS genetics 2015 Sep;11(9):e1005357
The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer.
Li H, Liu Q, Wang Z, Fang R, Shen Y, Cai X, Gao Y, Li Y, Zhang X, Ye L
The Journal of biological chemistry 2015 Sep 11;290(37):22649-61
The Journal of biological chemistry 2015 Sep 11;290(37):22649-61
The Steroid Hormone 20-Hydroxyecdysone Up-regulates Ste-20 Family Serine/Threonine Kinase Hippo to Induce Programmed Cell Death.
Dong DJ, Jing YP, Liu W, Wang JX, Zhao XF
The Journal of biological chemistry 2015 Oct 9;290(41):24738-46
The Journal of biological chemistry 2015 Oct 9;290(41):24738-46
Mulberry fruit prevents LPS-induced NF-κB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice.
Qian Z, Wu Z, Huang L, Qiu H, Wang L, Li L, Yao L, Kang K, Qu J, Wu Y, Luo J, Liu JJ, Yang Y, Yang W, Gou D
Scientific reports 2015 Nov 30;5:17348
Scientific reports 2015 Nov 30;5:17348
Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.
Xu LL, Zhu JF, Xu XL, Zhu J, Li L, Xi MY, Jiang ZY, Zhang MY, Liu F, Lu MC, Bao QC, Li Q, Zhang C, Wei JL, Zhang XJ, Zhang LS, You QD, Sun HP
Journal of medicinal chemistry 2015 Jul 23;58(14):5419-36
Journal of medicinal chemistry 2015 Jul 23;58(14):5419-36
Scutellarein inhibits cancer cell metastasis in vitro and attenuates the development of fibrosarcoma in vivo.
Shi X, Chen G, Liu X, Qiu Y, Yang S, Zhang Y, Fang X, Zhang C, Liu X
International journal of molecular medicine 2015 Jan;35(1):31-8
International journal of molecular medicine 2015 Jan;35(1):31-8
SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells.
Gao L, Wang Y, Xu Z, Li X, Wu J, Liu S, Chu P, Sun Z, Sun B, Lin Y, Peng J, Han G, Wang S, Tang Z
Apoptosis : an international journal on programmed cell death 2015 Dec;20(12):1636-50
Apoptosis : an international journal on programmed cell death 2015 Dec;20(12):1636-50
O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.
Liao H, Bao X, Zhu J, Qu J, Sun Y, Ma X, Wang E, Guo X, Kang Q, Zhen Y
Chemico-biological interactions 2015 Dec 5;242:91-8
Chemico-biological interactions 2015 Dec 5;242:91-8
Histone methyltransferase G9a and H3K9 dimethylation inhibit the self-renewal of glioma cancer stem cells.
Tao H, Li H, Su Y, Feng D, Wang X, Zhang C, Ma H, Hu Q
Molecular and cellular biochemistry 2014 Sep;394(1-2):23-30
Molecular and cellular biochemistry 2014 Sep;394(1-2):23-30
Role of NSD1 in H2O2-induced GSTM3 suppression.
Chu G, Li Y, Dong X, Liu J, Zhao Y
Cellular signalling 2014 Dec;26(12):2757-64
Cellular signalling 2014 Dec;26(12):2757-64
Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability.
Tian D, Qiu Y, Zhan Y, Li X, Zhi X, Wang X, Yin L, Ning Y
Cardiovascular diabetology 2012 Nov 21;11:144
Cardiovascular diabetology 2012 Nov 21;11:144
CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells.
Gong K, Xie J, Yi H, Li W
The Biochemical journal 2012 May 1;443(3):735-46
The Biochemical journal 2012 May 1;443(3):735-46
The oncoprotein HBXIP uses two pathways to up-regulate S100A4 in promotion of growth and migration of breast cancer cells.
Liu S, Li L, Zhang Y, Zhang Y, Zhao Y, You X, Lin Z, Zhang X, Ye L
The Journal of biological chemistry 2012 Aug 31;287(36):30228-39
The Journal of biological chemistry 2012 Aug 31;287(36):30228-39
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 17168-1-AP(Histone-H3 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Histone-H3 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human Histone-H3. This antibody recognizes human,mouse,rat antigen. The Histone-H3 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
