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- References [4]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 24746-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- FAM8A1 antibody
- Antibody type
- Polyclonal
- Description
- FAM8A1 antibody (Cat. #24746-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core Complex.
A small molecule VDAC ligand inhibits ERAD and induces selective cancer cell death via disruption of calcium homeostasis.
Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders.
SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex.
Lin LL, Maldosevic E, Zhou LE, Jomaa A, Qi L
Nature communications 2026 Jan 27;17(1)
Nature communications 2026 Jan 27;17(1)
A small molecule VDAC ligand inhibits ERAD and induces selective cancer cell death via disruption of calcium homeostasis.
Yan W, Talley DC, Syam A, Danchik C, Zhong Y, Zhang X, Liu X, Baljinnyam B, Kales SC, Cyr MG, Fang Y, Zakharov AV, Hu X, Niehoff T, Xu T, Qu Y, Yang A, Courouble VV, Yao Q, Simeonov A, Huang R, Rostovtseva TK, Bezrukov SM, LeClair CA, Egan JM, Wang H, Tao D, Rai G, Henderson MJ, Fang S
Nature communications 2026 Jan 17;17(1):1058
Nature communications 2026 Jan 17;17(1):1058
Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders.
Wang HH, Lin LL, Li ZJ, Wei X, Askander O, Cappuccio G, Hashem MO, Hubert L, Munnich A, Alqahtani M, Pang Q, Burmeister M, Lu Y, Poirier K, Besmond C, Sun S, Brunetti-Pierri N, Alkuraya FS, Qi L
The Journal of clinical investigation 2024 Jan 16;134(2)
The Journal of clinical investigation 2024 Jan 16;134(2)
SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex.
Lin LL, Wang HH, Pederson B, Wei X, Torres M, Lu Y, Li ZJ, Liu X, Mao H, Wang H, Zhou LE, Zhao Z, Sun S, Qi L
Nature communications 2024 Feb 16;15(1):1440
Nature communications 2024 Feb 16;15(1):1440
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 24746-1-AP( FAM8A1 Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FAM8A1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human FAM8A1. This antibody recognizes human, mouse antigen. The FAM8A1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
