66545-1-Ig

antibody from Proteintech Group

Targeting: STAT1 ISGF-3, STAT91

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66545-1-Ig

Provider

Proteintech Group

Product name

STAT1 antibody

Antibody type

Monoclonal

Description

KD/KO validated STAT1 antibody (Cat. #66545-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, rat, mouse and has been validated for the following applications: IHC, WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

1F7C6

Vial size

20ul, 150ul

References

Submitted references

IGF2BP2 Drives Thyroid Cancer Dedifferentiation Through m6A-Dependent STAT1 mRNA Destabilization.

Chen R, Li YX, Lu WL, Wu KF, Wang YX, Wang ZW, Li YH, Yang HY, Zhang X, Shi L, Zhou D, Wang Y, Ding Q
International journal of biological sciences 2026;22(2):622-640

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TEAD1 Enhances Exosome Secretion and Promotes Exosome-Mediated Tissue Regeneration.

Pu Y, Wan Y, Shi W, Li B, Zhang H, Wu J, Li L, Guo W, Ding C, Yang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(25):e14104

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Novel Dual-Pharmacophore TrxR Inhibitors Integrating Ferroptosis and Antitumor Immunity: A Closed-Loop Strategy for TIME Remodeling.

Xu Z, Yang Z, Lv L, Yang J, Liu W
Journal of medicinal chemistry 2026 May 14;69(9):10811-10827

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TGEV activates RIG-I/IFN-β/STAT1 axis to promote NLRC5-mediated SLA-I upregulation.

Wang W, Ma M, Bai H, Sun Y, Liu B, Gao A, Pan Q, Zheng D, Li M, Jiang W, Ma S, Wei Z, Zhang H, Zheng L
Veterinary research 2026 Mar 9;57(1)

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Ursodeoxycholic acid inhibits pneumonia caused by PRCV through the activation of TLR4-IRF3 mediated type Ⅰ interferon pathway.

Zhang X, Liao G, Ding J, Sun Z, Zhong Y, Song Y, Li Y, Song Z
Veterinary research 2026 Mar 2;57(1)

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ST6Gal1 influences the esophageal squamous cell carcinoma resistance to IFN-γ by regulating the expression of IFN-γ receptor 1.

Zhang K, Zhang N, Zhang Y, Zhao W, Chen S, Song W, Li W
Biochimica et biophysica acta. General subjects 2026 Jun;1870(6):130941

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Type I Interferons Induce CD8(+) T Cell Chemotaxis Through Regulating Melanocyte but Not Keratinocyte CXCL9/10/11 Secretion in the Initiation of Vitiligo.

Wang D, Yang L, Zhang Y, Zhang H, Yang L, Chen L, Katayama I, Li Y, Chen K, Wu H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 28;40(4):e71575

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Targeting the ZDHHC9-mediated STAT1 palmitoylation-phosphorylation conversion inhibits gastric cancer progression.

Bai X, Guo YR, Zhang WC, Shi ZH, Dai DQ
Journal of gastroenterology 2026 Apr;61(4):369-385

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USP13 stabilizes SOCS1 to reverse αPD-1 resistance in MSI-H colorectal cancer.

Zheng Z, Ni Y, Wu M, Ding L, Li H, Zhang N, Jin X, Zheng H, Jiang B, Wang S, Xu W, Wang Q, Fu J
Oncogene 2026 Apr 18;

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The Tumor-Promoting Role of ADM in Bladder Cancer and its Mediated Mechanisms of Cell Death via PKR and STAT1.

Sun X, Qi Q, Ding X, Wang X, Shao S, Ding D, Liu Y
Applied biochemistry and biotechnology 2026 Apr 14;

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Calycosin inhibits porcine reproductive and respiratory syndrome virus replication and activates RIG-I/IRF3 signaling pathway.

Chang Y, Li Z, Wang M, Pei K, Chang X, Ma J
Frontiers in veterinary science 2025;12:1674259

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Ipriflavone Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection via RIG-I/IRF3-Mediated Interferon Signaling.

Chang Y, Li Z, Pei K, Wang M, Chang X
Animals : an open access journal from MDPI 2025 Sep 29;15(19)

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TSN Disrupts Fanconi Anemia Pathway Activation Through JAK/STAT1-Mediated Transcriptional Repression of FA Core Subunits in Bladder Cancer.

Zhao W, Xie Z, Zhu L, Li W
Dose-response : a publication of International Hormesis Society 2025 Oct-Dec;23(4):15593258251406039

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Multimodal characterization of the responsiveness of eight hepatitis D virus genotype isolates to interferon-alpha treatment.

Ding Y, Li Q, Sha Y, Si R, Feng C, Liu M, Feng Z, Ding X, Li Y, Fu H, Liang S, Yao Q, Zhang Z, Li F, Urban S, Guo H, Wang W
Journal of virology 2025 Oct 23;99(10):e0128025

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Intrinsic errors in mitochondrial translation trigger a decline in cell fitness.

Bal GL, Ng KY, Berzell E, Akpinar A, Ekvik AE, Koludarova L, Naddafi S, Raths C, Vane-Tempest T, VanPortfliet JJ, O'Keefe S, Najumudeen AK, Nyman TA, Stewart JB, West AP, Battersby BJ
bioRxiv : the preprint server for biology 2025 Oct 15;

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Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer's disease.

Song Z, Xie X, Chen Y, Zhang B, Li X, Yang Y, Mo W, Zhang J, Xu D
Immunity 2025 Oct 14;58(10):2574-2592.e9

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TLR-4Ab and IFNγAb with exogenous IL-10 treated LPS induced mice shown differential inflammatory response upon RANKL-M-CSF stimulation in resident bone marrow cells.

Mukherjee G, Samanta S, Bishayi B
Microbial pathogenesis 2025 May;202:107416

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Bone marrow mesenchymal stem cells alleviate liver fibrosis after rat liver transplantation through JAK1/STAT5 pathway.

Si Z, Zhao S, Zhang Z, Chen T, Wang R, Dong C, Wang K, Sun C, Song Z, Shen Z, Gao W
Stem cell research & therapy 2025 May 1;16(1):217

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The effect and mechanism of sanguinarine against PCV2 based on the analysis of network pharmacology and TMT quantitative proteomics.

Zhang S, Li H, Wang X, Sun P, Zhang H, Yin W, Fan K, Yang H, Zhang Z, Zhong J, Sun Y, Sun N
International journal of biological macromolecules 2025 Mar;296:139767

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STAT1 mediates the pro-inflammatory role of GBP5 in colitis.

Li Y, Wang W, Zhu R, Zhu X, Sun M, Huang Y, Chen W, Gao S, Jiao N, Lin X, Ke J, Xu T, Hou L, Lan P, Zhu L
Communications biology 2025 Mar 7;8(1):385

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Spontaneous Bacterial Peritonitis in Advanced Cirrhosis: Diagnosis by Tm Mapping and Inflammatory Profiles of Extracellular Vesicles.

Murayama A, Tajiri K, Muraishi N, Hayashi Y, Minemura M, Niimi H, Yasuda I
Journal of clinical medicine 2025 Jul 17;14(14)

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Exploring the anti-inflammatory mechanism of geniposide in rheumatoid arthritis via network pharmacology and experimental validation.

Huang M, Jiang J, Li YJ, Jiang MY, Yang M, Deng H, Wu YG, Wu LJ, Leng X, Chen JL, Sun WK
Scientific reports 2025 Jul 10;15(1):24812

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Integrated proteogenomic characterization of ampullary adenocarcinoma.

Zhang Q, Xu X, Jiang D, Wang Y, Wang H, Zhu J, Tang S, Wang R, Zhao S, Li K, Feng J, Xiang H, Yao Z, Xu N, Fang R, Guo W, Liu Y, Hou Y, Ding C
Cell discovery 2025 Jan 7;11(1):2

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The antiviral activity of myricetin against pseudorabies virus through regulation of the type I interferon signaling pathway.

Song Y, Zhao X, Chen Y, Yu X, Su T, Wang J, He T, Yin Z, Jia R, Zhao X, Zhou X, Li L, Zou Y, Li M, Zhang D, Zhang Y, Song X
Journal of virology 2025 Jan 31;99(1):e0156724

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Dual neutralization of TGF-β and IL-21 regulates Th17/Treg balance by suppressing inflammatory signalling in the splenic lymphocytes of Staphylococcus aureus infection-induced septic arthritic mice.

Pramanik R, Chattopadhyay S, Bishayi B
Immunologic research 2025 Jan 20;73(1):38

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A novel Cdc42-YAP-fibronectin signaling axis regulates ameloblast differentiation during early enamel formation.

Zhang J, Gao J, Zeng X, Wang Z, Chen C, Rong C, Li S, Cai L, Wang L, Zhang L, Tian Z
Biochimica et biophysica acta. Molecular basis of disease 2025 Feb;1871(2):167570

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4D-DIA-based proteomics analysis reveals the protective effects of Pidanjiangtang granules in IGT rat model.

Xie Y, Fan Y, Liu X, Li Z, Liu S
Journal of ethnopharmacology 2025 Feb 10;338(Pt 1):119012

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Human cytomegalovirus UL23 inhibits immune cell migration and blocks antiviral immune cell responses by reducing the expression of chemokines CCL2 and CCL5.

Wang H, Zhang C, Li M, Zhao W, Wang J, Ran Y, Yang X, Deng Z, Chen J, Li H
Virulence 2025 Dec;16(1):2500493

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Steroid Receptor Coactivator-1 Drives Tumor-Associated Macrophage Reprogramming by Mediating MMP12 Transcription in Pancreatic Cancer Perineural Invasion.

Cheng K, Liu L, Gong M, Ji Y, Bai C, Guo X, Chen H, Pan J, Zhang Y, Yuan Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e16575

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Pathogenesis of impaired glucose tolerance in rats based on transcriptome analysis.

Yi R, Xie Y, Fan Y, Liu X, Yang Z, Liu S
Scientific reports 2025 Dec 29;15(1):44908

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Tanshinone IIA ameliorates septic immunosuppression by balancing the Th17/Treg cell ratio and modulating Treg function after induction of autophagy.

Ou H, Sun B, Jiang Y, Gao M
Archives of biochemistry and biophysics 2025 Aug;770:110451

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Effect and underlying mechanism of Huangjing Qianshi decoction in pre-diabetes mouse model.

Cai J, Zhu Y, Deng G, Ouyang L, Xiao W, Zhou F, Han Y, Yuan F, Huang L, Li X
BMC complementary medicine and therapies 2025 Apr 23;25(1):151

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TLR4/TNFR1 blockade suppresses STAT1/STAT3 expression and increases SOCS3 expression in modulation of LPS-induced macrophage responses.

Sawoo R, Bishayi B
Immunobiology 2024 Sep;229(5):152840

---

Persistent tailoring of MSC activation through genetic priming.

Beauregard MA, Bedford GC, Brenner DA, Sanchez Solis LD, Nishiguchi T, Abhimanyu, Longlax SC, Mahata B, Veiseh O, Wenzel PL, DiNardo AR, Hilton IB, Diehl MR
Molecular therapy. Methods & clinical development 2024 Sep 12;32(3):101316

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Cordycepin inhibits glioma growth by downregulating PD-L1 expression via the NOD-like receptor/NFKB1/STAT1 axis.

Chen J, Liang RS, Zhuang BB, Chen HD, Liu S, Zhang GL, Shi SS
Chemico-biological interactions 2024 Sep 1;400:111178

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TRIM32 inhibits Venezuelan equine encephalitis virus infection by targeting a late step in viral entry.

Xie Y, Cao J, Gan S, Xu L, Zhang D, Qian S, Xu F, Ding Q, Schoggins JW, Fan W
PLoS pathogens 2024 Nov;20(11):e1012312

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IRF7 from the black flying fox induces a STAT1-independent ISG response in unstimulated cell lines that protects against diverse RNA viruses.

Cruz-Rivera PC, Eitson JL, Schoggins JW
bioRxiv : the preprint server for biology 2024 May 5;

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Verapamil and tangeretin enhances the M1 macrophages to M2 type in lipopolysaccharide-treated mice and inhibits the P-glycoprotein expression by downregulating STAT1/STAT3 and upregulating SOCS3.

Kundu A, Ghosh P, Bishayi B
International immunopharmacology 2024 May 30;133:112153

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Resveratrol-loaded sulfated Hericium erinaceus β-glucan-chitosan nanoparticles: Preparation, characterization and synergistic anti-inflammatory effects.

Zhang Z, Ge M, Wu D, Li W, Chen W, Liu P, Zhang H, Yang Y
Carbohydrate polymers 2024 May 15;332:121916

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Histone lysine demethylase KDM5B facilitates proliferation and suppresses apoptosis in human acute myeloid leukemia cells through the miR-140-3p/BCL2 axis.

Huang J, Jin S, Guo R, Wu W, Yang C, Qin Y, Chen Q, He X, Qu J, Yang Z
RNA (New York, N.Y.) 2024 Mar 18;30(4):435-447

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TRIM32 inhibits Venezuelan Equine Encephalitis Virus Infection by targeting a late step in viral entry.

Xie Y, Cao J, Gan S, Xu L, Zhang D, Qian S, Xu F, Ding Q, Schoggins JW, Fan W
bioRxiv : the preprint server for biology 2024 Jun 4;

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Classical swine fever virus non-structural protein 4A recruits dihydroorotate dehydrogenase to facilitate viral replication.

Zhao B-q, Chen J, Chen J-X, Cheng Y, Zhou J-f, Bai J-s, Mao D-y, Zhou B
Journal of virology 2024 Jun 13;98(6):e0049424

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RACK1 enhances STAT3 stability and promotes T follicular helper cell development and function during blood-stage Plasmodium infection in mice.

Cheng Q, Yang X, Zou T, Sun L, Zhang X, Deng L, Wu M, Gai W, Jiang H, Guo T, Lu Y, Dong J, Niu C, Pan W, Zhang J
PLoS pathogens 2024 Jul;20(7):e1012352

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Intermittent hypoxia exacerbates anxiety in high-fat diet-induced diabetic mice by inhibiting TREM2-regulated IFNAR1 signaling.

Ni W, Niu Y, Cao S, Fan C, Fan J, Zhu L, Wang X
Journal of neuroinflammation 2024 Jul 2;21(1):166

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IL-21-armored B7H3 CAR-iNKT cells exert potent antitumor effects.

Liu Y, Dang Y, Zhang C, Liu L, Cai W, Li L, Fang L, Wang M, Xu S, Wang G, Zheng J, Li H
iScience 2024 Jan 19;27(1):108597

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Endogenous blocking of TLR2 along with TNF-α and IL-1β ameliorates the severity of the S. aureus arthritis via modulating STAT3/SOCS3 expressions in tissue resident macrophages.

Ghosh R, Bishayi B
Microbial pathogenesis 2024 Feb;187:106518

---

Persistent tailoring of MSC activation through genetic priming.

Beauregard MA, Bedford GC, Brenner DA, Sanchez Solis LD, Nishiguchi T, Abhimanyu, Longlax SC, Mahata B, Veiseh O, Wenzel PL, DiNardo AR, Hilton IB, Diehl MR
bioRxiv : the preprint server for biology 2024 Feb 7;

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Single cell analysis reveals the roles and regulatory mechanisms of type-I interferons in Parkinson's disease.

Quan P, Li X, Si Y, Sun L, Ding FF, Fan Y, Liu H, Wei C, Li R, Zhao X, Yang F, Yao L
Cell communication and signaling : CCS 2024 Apr 2;22(1):212

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Interferon inhibits a model RNA virus via a limited set of inducible effector genes.

McDougal MB, De Maria AM, Ohlson MB, Kumar A, Xing C, Schoggins JW
EMBO reports 2023 Sep 6;24(9):e56901

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IL-17 promotes melanoma through TRAF2 as a scaffold protein recruiting PIAS2 and ELAVL1 to induce EPHA5.

Du J, Du Y, Chen L, Liu H
Biochimica et biophysica acta. Molecular cell research 2023 Oct;1870(7):119547

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Silencing SIRT1 promotes the anti-HBV action of IFN-α by regulating Pol expression and activating the JAK-STAT signaling pathway.

Tang Q, Meng C, Liu Y, Cheng Y, Liu Y, Long Y, Sun S, Feng F
International immunopharmacology 2023 Nov;124(Pt B):110939

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GSTM2 alleviates heart failure by inhibiting DNA damage in cardiomyocytes.

Xu H, Wang Z, Wang Y, Pan S, Zhao W, Chen M, Chen X, Tao T, Ma L, Ni Y, Li W
Cell & bioscience 2023 Nov 30;13(1):220

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POR overexpression induces tamoxifen-resistance in breast cancer through the STAT1/c-Myc pathway.

Chen S, Wu D, Liu Q, Jin F, Yao F, Fang Y
Molecular carcinogenesis 2023 Feb;62(2):249-260

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Retinoic Acid Prevents α-Synuclein Preformed Fibrils-Induced Toxicity via Inhibiting STAT1-PARP1 Signaling.

Zhou L, Ma Z, Gao X
Molecular neurobiology 2023 Aug;60(8):4828-4841

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Free ISG15 inhibits Pseudorabies virus infection by positively regulating type I IFN signaling.

Liu H, Li C, He W, Chen J, Yang G, Chen L, Chang H
PLoS pathogens 2022 Oct;18(10):e1010921

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Proteome-centric cross-omics characterization and integrated network analyses of triple-negative breast cancer.

Gong TQ, Jiang YZ, Shao C, Peng WT, Liu MW, Li DQ, Zhang BY, Du P, Huang Y, Li FF, Li MY, Han ZL, Jin X, Ma D, Xiao Y, Yang PY, Qin J, Shao ZM, Zhu W
Cell reports 2022 Mar 1;38(9):110460

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lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions.

Zhao B, Li J, Liu M, Hu S, Yang N, Liang S, Zhang X, Dai Y, Bao Z, Chen Y, Wu X
Cells 2022 Aug 6;11(15)

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Panax notoginseng saponins prevent colitis-associated colorectal cancer via inhibition IDO1 mediated immune regulation.

Li XM, Yuan DY, Liu YH, Zhu L, Qin HK, Yang YB, Li Y, Yan F, Wang YJ
Chinese journal of natural medicines 2022 Apr;20(4):258-269

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Dual Inhibition of Endoplasmic Reticulum Stress and Oxidation Stress Manipulates the Polarization of Macrophages under Hypoxia to Sensitize Immunotherapy.

Jiang M, Li X, Zhang J, Lu Y, Shi Y, Zhu C, Liu Y, Qin B, Luo Z, Du Y, Luo L, Peng L, You J
ACS nano 2021 Sep 28;15(9):14522-14534

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Comparative proteomics reveals Cryptosporidium parvum manipulation of the host cell molecular expression and immune response.

Li T, Liu H, Jiang N, Wang Y, Wang Y, Zhang J, Shen Y, Cao J
PLoS neglected tropical diseases 2021 Nov;15(11):e0009949

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Statins attenuate antiviral IFN-β and ISG expression via inhibition of IRF3 and JAK/STAT signaling in poly(I:C)-treated hyperlipidemic mice and macrophages.

Koike A, Tsujinaka K, Fujimori K
The FEBS journal 2021 Jul;288(14):4249-4266

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Increased expression of IFN-γ in preeclampsia impairs human trophoblast invasion via a SOCS1/JAK/STAT1 feedback loop.

Liu H, Wang W, Liu C
Experimental and therapeutic medicine 2021 Feb;21(2):112

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Bicarbonate enhances the inflammatory response by activating JAK/STAT signalling in LPS + IFN-γ-stimulated macrophages.

Kawakami T, Koike A, Maehara T, Hayashi T, Fujimori K
Journal of biochemistry 2020 Jun 1;167(6):623-631

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Rhein attenuates renal inflammatory injury of uric acid nephropathy via lincRNA-Cox2/miR-150-5p/STAT1 axis.

Hu J, Yang Z, Wu H, Wang D
International immunopharmacology 2020 Aug;85:106620

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E2F2 directly regulates the STAT1 and PI3K/AKT/NF-κB pathways to exacerbate the inflammatory phenotype in rheumatoid arthritis synovial fibroblasts and mouse embryonic fibroblasts.

Wang S, Wang L, Wu C, Sun S, Pan JH
Arthritis research & therapy 2018 Oct 4;20(1):225