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antibody from GeneTex
Targeting: NBN
AT-V1, AT-V2, ATV, NBS, NBS1
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- Antigen structure
- References [5]
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- Validations
- Western blot [2]
- Immunocytochemistry [2]
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- Product number
- GTX30125 - Provider product page
- Provider
- GeneTex
- Proper citation
- GeneTex Cat#GTX30125, RRID:AB_386040
- Product name
- NBS1 antibody
- Antibody type
- Polyclonal
- Reactivity
- Human, Mouse, Hamster, Simian
- Host
- Rabbit
Submitted references The UBC Domain Is Required for BRUCE to Promote BRIT1/MCPH1 Function in DSB Signaling and Repair Post Formation of BRUCE-USP8-BRIT1 Complex.
BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1.
Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients.
Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest.
Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome.
Ge C, Che L, Du C
PloS one 2015;10(12):e0144957
PloS one 2015;10(12):e0144957
BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1.
Ge C, Che L, Ren J, Pandita RK, Lu J, Li K, Pandita TK, Du C
Proceedings of the National Academy of Sciences of the United States of America 2015 Mar 17;112(11):E1210-9
Proceedings of the National Academy of Sciences of the United States of America 2015 Mar 17;112(11):E1210-9
Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients.
Siwicki JK, Degerman S, Chrzanowska KH, Roos G
Experimental cell research 2003 Jul 1;287(1):178-89
Experimental cell research 2003 Jul 1;287(1):178-89
Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest.
Franchitto A, Pichierri P
The Journal of cell biology 2002 Apr 1;157(1):19-30
The Journal of cell biology 2002 Apr 1;157(1):19-30
Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome.
Harfst E, Cooper S, Neubauer S, Distel L, Grawunder U
Molecular immunology 2000 Oct;37(15):915-29
Molecular immunology 2000 Oct;37(15):915-29
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Enhanced validation
Supportive validation
- Submitted by
- GeneTex (provider)
- Enhanced method
- Genetic validation
- Main image
- Experimental details
- Western Blot: NBS1 Antibody (GTX30125) - Detection of NBS1 in Human Bone Osteosarcoma Epithelial Cells (U2OS whole cell lysate) using GTX30125 at a dilution of 1/1000. Specificity was confirmed using a siRNA anti-NBS1 (targeting sequence: GGAAGAAACGμgAACUCAA).
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Western Blot: NBS1 Antibody (GTX30125) - Detection of human NBS1 using GTX30125.
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Indirect immunofluorescence to detect localisation of NBS1 in normal lymphoblastoid cells. (Panel D - negative control).
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Immunocytochemistry/Immunofluorescence: NBS1 Antibody (GTX30125) - ICC staining of Hela cells using GTX30125 anti-NBS1.
