Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations [0]
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- Product number
- 613802 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#613802, RRID:AB_2149251
- Product name
- Purified anti-NBS1
- Antibody type
- Polyclonal
- Antigen
- Recombinant (partial), C-terminal
- Description
- NBS1 (Nijmegen breakage syndrome 1, p95 protein of the MRE11/RAD50 complex) is a 95 kD nuclear protein that contains a FHA domain and BRCT domain. NBS1 is involved in DNA double-strand break repair, and DNA damage-induced checkpoint activation. NBS1 mutations are associated with Nijmegen breakage syndrome, characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. This protein is activated by irradiation, upregulated by c-Myc, and modified by phosphorylation. NBS1 is a component of the double-strand break repair complex consisting of DNL IV/XRCC4, Ku, MRE11, and RAD50. NBS1 has also been shown to associate with FANCD2. The Poly6138 antibody recognizes the C-terminal region of human and mouse NBS1 and has been shown to be useful for Western blotting.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Vial size
- 200 µl
- Storage
- Upon receipt, store frozen at -20° C.
Submitted references Human T-lymphotropic type 1 virus p30 inhibits homologous recombination and favors unfaithful DNA repair.
Baydoun HH, Pancewicz J, Nicot C
Blood 2011 Jun 2;117(22):5897-906
Blood 2011 Jun 2;117(22):5897-906
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