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- References [21]
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- Product number
- 55025-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#55025-1-AP, RRID:AB_10858928
- Product name
- NBS1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NBS1 antibody (Cat. #55025-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Saikosaponin D Mitigates Radioresistance in Triple-Negative Breast Cancer by Inducing MRE11 De-Lactylation via HIF1α/HDAC5 Pathway.
Phase separation of ERCC6L2-CtIP regulates the extent of DNA end resection.
m(6)A Reader hnRNPA2B1 Modulates Late Pachytene Progression in Male Meiosis Through Post-Transcriptional Control.
HAT1 functions as a lactyltransferase and mediates RPA1 lactylation to promote DNA repair and radioresistance in lung adenocarcinoma.
CNOT7 facilitates radiation resistance in colorectal cancer through TRIM21/XRCC6-mediated non-homologous end joining repair.
Adolescent cetylpyridinium chloride exposure impairs homologous recombination repair and induces granulosa cell apoptosis and follicular atresia via FOXM1/CREBBP complex suppression.
NBS1 dePARylation by NUDT16 is critical for DNA double-strand break repair.
NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors.
PKCδ Regulates Chromatin Remodeling and DNA Repair through SIRT6.
PKCδ regulates chromatin remodeling and DNA repair through SIRT6.
TRIM24 is critical for the cellular response to DNA double-strand breaks through regulating the recruitment of MRN complex.
Phosphorylated Hsp27 promotes adriamycin resistance in breast cancer cells through regulating dual phosphorylation of c-Myc.
Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin.
FOXO3a Mediates Homologous Recombination Repair (HRR) via Transcriptional Activation of MRE11, BRCA1, BRIP1, and RAD50.
cGAS regulates the DNA damage response to maintain proliferative signaling in gastric cancer cells.
LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma.
NBS1 is required for SPO11-linked DNA double-strand break repair in male meiosis.
C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex.
Reprogramming and differentiation-dependent transcriptional alteration of DNA damage response and apoptosis genes in human induced pluripotent stem cells.
MiR-34s negatively regulate homologous recombination through targeting RAD51.
LncRNA lnc-RI regulates homologous recombination repair of DNA double-strand breaks by stabilizing RAD51 mRNA as a competitive endogenous RNA.
Li J, Feng L, Zhang L, Zhang W, Zhang Y, Liu X, Cai Q, Zhao W, Huang G, Lu C
Theranostics 2025;15(17):8935-8951
Theranostics 2025;15(17):8935-8951
Phase separation of ERCC6L2-CtIP regulates the extent of DNA end resection.
Yin Y, Lin J, Cai X, Nie R, Lin J, Li S, Xiang Z, Ling Y, Zhang Y, Zhou J, Chen J, Lin W, Duan J, Zheng X, Xie D, Cai M
Nature cell biology 2025 Oct;27(10):1771-1784
Nature cell biology 2025 Oct;27(10):1771-1784
m(6)A Reader hnRNPA2B1 Modulates Late Pachytene Progression in Male Meiosis Through Post-Transcriptional Control.
Yin L, Zhang Y, Zhang B, Zhang J, Xiong M, Jiang N, Xiao J, Gao H, Xiong W, Wang X, Wang F, Yuan S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e06600
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e06600
HAT1 functions as a lactyltransferase and mediates RPA1 lactylation to promote DNA repair and radioresistance in lung adenocarcinoma.
He J, Lai T, Zhao Y, Zhou Z, Zhou L, Tao D, Yang H, Li N, He Y, Yang S, Tang Z, Zeng S, Munai E, Liu Y, Tan Y, Zhou W, Wu Y
Cell death & disease 2025 Nov 21;16(1):851
Cell death & disease 2025 Nov 21;16(1):851
CNOT7 facilitates radiation resistance in colorectal cancer through TRIM21/XRCC6-mediated non-homologous end joining repair.
Li Y, Cui L, Wang S, Zhao Q, Du F, Du S, Yu C, Xia M, Zhao S, Luan T, Liu Y, Cui B
Cell death & disease 2025 Nov 17;16(1):833
Cell death & disease 2025 Nov 17;16(1):833
Adolescent cetylpyridinium chloride exposure impairs homologous recombination repair and induces granulosa cell apoptosis and follicular atresia via FOXM1/CREBBP complex suppression.
Ma L, Yin X, Zhang Y, Ma Y, Geng Y, Mu X, Gao R, Chen X, He J
Ecotoxicology and environmental safety 2025 May;296:118193
Ecotoxicology and environmental safety 2025 May;296:118193
NBS1 dePARylation by NUDT16 is critical for DNA double-strand break repair.
Zhang Z, Samsa WE, Gong Z
Molecular and cellular biochemistry 2025 Apr;480(4):2595-2609
Molecular and cellular biochemistry 2025 Apr;480(4):2595-2609
NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors.
Wang Y, Liu X, Zuo X, Wang C, Zhang Z, Zhang H, Zeng T, Chen S, Liu M, Chen H, Song Q, Li Q, Yang C, Le Y, Xing J, Zhang H, An J, Jia W, Kang L, Zhang H, Xie H, Ye J, Wu T, He F, Zhang X, Li Y, Zhou G
Cell genomics 2024 May 8;4(5):100550
Cell genomics 2024 May 8;4(5):100550
PKCδ Regulates Chromatin Remodeling and DNA Repair through SIRT6.
Affandi T, Haas A, Ohm AM, Wright GM, Black JC, Reyland ME
Molecular cancer research : MCR 2024 Feb 1;22(2):181-196
Molecular cancer research : MCR 2024 Feb 1;22(2):181-196
PKCδ regulates chromatin remodeling and DNA repair through SIRT6.
Affandi T, Haas A, Ohm AM, Wright GM, Black JC, Reyland ME
bioRxiv : the preprint server for biology 2023 May 24;
bioRxiv : the preprint server for biology 2023 May 24;
TRIM24 is critical for the cellular response to DNA double-strand breaks through regulating the recruitment of MRN complex.
Wang Y, Yao Y, Wei Q, Long S, Chen Y, Xie J, Tan R, Jiang W, Zhang Q, Wu D, Xiao S, Wan F, Fu K
Oncogene 2023 Feb;42(8):586-600
Oncogene 2023 Feb;42(8):586-600
Phosphorylated Hsp27 promotes adriamycin resistance in breast cancer cells through regulating dual phosphorylation of c-Myc.
Bi X, Zhang M, Zhou J, Yan X, Cheng L, Luo L, Huang C, Yin Z
Cellular signalling 2023 Dec;112:110913
Cellular signalling 2023 Dec;112:110913
Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin.
Zhang T, Yang H, Zhou Z, Bai Y, Wang J, Wang W
Nature communications 2022 Sep 1;13(1):5133
Nature communications 2022 Sep 1;13(1):5133
FOXO3a Mediates Homologous Recombination Repair (HRR) via Transcriptional Activation of MRE11, BRCA1, BRIP1, and RAD50.
Inci G, Warkad MS, Kang BG, Lee NK, Suh HW, Lim SS, Kim J, Kim SC, Lee JY
Molecules (Basel, Switzerland) 2022 Dec 6;27(23)
Molecules (Basel, Switzerland) 2022 Dec 6;27(23)
cGAS regulates the DNA damage response to maintain proliferative signaling in gastric cancer cells.
Liu B, Liu H, Ren F, Liu H, Bukhari I, Fu Y, Wu W, Zhao M, Zhu S, Mo H, Li F, Zheng MB, Tang Y, Zheng P, Mi Y
Oncology research 2021;29(2):87-103
Oncology research 2021;29(2):87-103
LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma.
Guo Z, Wang YH, Xu H, Yuan CS, Zhou HH, Huang WH, Wang H, Zhang W
Cell death & disease 2021 Jan 4;12(1):69
Cell death & disease 2021 Jan 4;12(1):69
NBS1 is required for SPO11-linked DNA double-strand break repair in male meiosis.
Zhang B, Tang Z, Li L, Lu LY
Cell death and differentiation 2020 Jul;27(7):2176-2190
Cell death and differentiation 2020 Jul;27(7):2176-2190
C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex.
Bai Y, Wang W, Li S, Zhan J, Li H, Zhao M, Zhou XA, Li S, Li X, Huo Y, Shen Q, Zhou M, Zhang H, Luo J, Sung P, Zhu WG, Xu X, Wang J
Molecular cell 2019 Sep 19;75(6):1299-1314.e6
Molecular cell 2019 Sep 19;75(6):1299-1314.e6
Reprogramming and differentiation-dependent transcriptional alteration of DNA damage response and apoptosis genes in human induced pluripotent stem cells.
Shimada M, Tsukada K, Kagawa N, Matsumoto Y
Journal of radiation research 2019 Nov 22;60(6):719-728
Journal of radiation research 2019 Nov 22;60(6):719-728
MiR-34s negatively regulate homologous recombination through targeting RAD51.
Chen S, Liu R, Wang Q, Qi Z, Hu Y, Zhou P, Wang Z
Archives of biochemistry and biophysics 2019 May 15;666:73-82
Archives of biochemistry and biophysics 2019 May 15;666:73-82
LncRNA lnc-RI regulates homologous recombination repair of DNA double-strand breaks by stabilizing RAD51 mRNA as a competitive endogenous RNA.
Shen L, Wang Q, Liu R, Chen Z, Zhang X, Zhou P, Wang Z
Nucleic acids research 2018 Jan 25;46(2):717-729
Nucleic acids research 2018 Jan 25;46(2):717-729
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NBN antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human NBN. This antibody recognizes human, mouse, rat antigen. The NBN antibody has been validated for the following applications: ELISA, WB analysis.
