CCRL2

This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]

Description

C-C motif chemokine receptor like 2

Tissue specificity

Low tissue specificity

Predicted location

Membrane

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

3 (46407166 - 46412997)

Ensembl ID

ENSG00000121797  (ver. 103.38)

Orthologs

Mouse Ccrl2: ENSMUSG00000043953

UniProt

O00421

neXtProt

NX_O00421

Human splice variants
Mouse splice variants

Protein structure