Antibody data
- Antibody Data
- Antigen structure
- References [12]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 11214-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11214-1-AP, RRID:AB_2173235
- Product name
- PTPN2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PTPN2 antibody (Cat. #11214-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references An immune signature to predict the prognosis of ATRX-wildtype glioma patients and guide immune checkpoint blockade therapy.
Oral squamous cell carcinoma-derived EVs promote tumor progression by regulating inflammatory cytokines and the IL-17A-induced signaling pathway.
Hypoxia disrupts the nasal epithelial barrier by inhibiting PTPN2 in chronic rhinosinusitis with nasal polyps.
Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance.
Protein tyrosine phosphatase PTPN2 regulates TGF-β signaling through Smad4 dephosphorylation.
Overexpression of TC-PTP in murine epidermis attenuates skin tumor formation.
ERBB2 and PTPN2 gene copy numbers as prognostic factors in HER2-positive metastatic breast cancer treated with trastuzumab.
PTPN2 deficiency along with activation of nuclear Akt predict endocrine resistance in breast cancer.
The effects of PTPN2 loss on cell signalling and clinical outcome in relation to breast cancer subtype.
Cryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation.
Targeted disruption of TC-PTP in the proliferative compartment augments STAT3 and AKT signaling and skin tumor development.
An Ehrlichia chaffeensis tandem repeat protein interacts with multiple host targets involved in cell signaling, transcriptional regulation, and vesicle trafficking.
Cao W, Sun P, Luo S, Zeng Z, Xiao C, Yu W, Lei S
Aging 2023 Oct 6;15(19):10453-10472
Aging 2023 Oct 6;15(19):10453-10472
Oral squamous cell carcinoma-derived EVs promote tumor progression by regulating inflammatory cytokines and the IL-17A-induced signaling pathway.
Li R, Zhou Y, Zhang M, Xie R, Duan N, Liu H, Qin Y, Ma J, Li Z, Ye P, Wang W, Wang X
International immunopharmacology 2023 May;118:110094
International immunopharmacology 2023 May;118:110094
Hypoxia disrupts the nasal epithelial barrier by inhibiting PTPN2 in chronic rhinosinusitis with nasal polyps.
Zhang M, Xiong Y, Tu J, Tang B, Zhang Z, Yu J, Shen L, Luo Q, Ye J
International immunopharmacology 2023 May;118:110054
International immunopharmacology 2023 May;118:110054
Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance.
Gao X, Wu Y, Chick JM, Abbott A, Jiang B, Wang DJ, Comte-Walters S, Johnson RH, Oberholtzer N, Nishimura MI, Gygi SP, Mehta A, Guttridge DC, Ball L, Mehrotra S, Sicinski P, Yu XZ, Wang H
Cell reports 2023 Apr 25;42(4):112314
Cell reports 2023 Apr 25;42(4):112314
Protein tyrosine phosphatase PTPN2 regulates TGF-β signaling through Smad4 dephosphorylation.
Shi S, Xu D, Gu S, Xu N, Xu P, Cao J, Feng XH
American journal of cancer research 2022;12(12):5516-5531
American journal of cancer research 2022;12(12):5516-5531
Overexpression of TC-PTP in murine epidermis attenuates skin tumor formation.
Kim M, Morales LD, Lee CJ, Olivarez SA, Kim WJ, Hernandez J, Mummidi S, Jenkinson C, Tsin AT, Jang IS, Slaga TJ, Kim DJ
Oncogene 2020 May;39(21):4241-4256
Oncogene 2020 May;39(21):4241-4256
ERBB2 and PTPN2 gene copy numbers as prognostic factors in HER2-positive metastatic breast cancer treated with trastuzumab.
Ellegård S, Veenstra C, Pérez-Tenorio G, Fagerström V, Gårsjö J, Gert K, Sundquist M, Malmström A, Wingren S, Elander NO, Hallbeck AL, Stål O
Oncology letters 2019 Mar;17(3):3371-3381
Oncology letters 2019 Mar;17(3):3371-3381
PTPN2 deficiency along with activation of nuclear Akt predict endocrine resistance in breast cancer.
Karlsson E, Veenstra C, Gårsjö J, Nordenskjöld B, Fornander T, Stål O
Journal of cancer research and clinical oncology 2019 Mar;145(3):599-607
Journal of cancer research and clinical oncology 2019 Mar;145(3):599-607
The effects of PTPN2 loss on cell signalling and clinical outcome in relation to breast cancer subtype.
Veenstra C, Karlsson E, Mirwani SM, Nordenskjöld B, Fornander T, Pérez-Tenorio G, Stål O
Journal of cancer research and clinical oncology 2019 Jul;145(7):1845-1856
Journal of cancer research and clinical oncology 2019 Jul;145(7):1845-1856
Cryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation.
Lu L, Zhang S, Li C, Zhou C, Li D, Liu P, Huang M, Shen X
Cell death & disease 2017 May 11;8(5):e2767
Cell death & disease 2017 May 11;8(5):e2767
Targeted disruption of TC-PTP in the proliferative compartment augments STAT3 and AKT signaling and skin tumor development.
Lee H, Kim M, Baek M, Morales LD, Jang IS, Slaga TJ, DiGiovanni J, Kim DJ
Scientific reports 2017 Mar 21;7:45077
Scientific reports 2017 Mar 21;7:45077
An Ehrlichia chaffeensis tandem repeat protein interacts with multiple host targets involved in cell signaling, transcriptional regulation, and vesicle trafficking.
Wakeel A, Kuriakose JA, McBride JW
Infection and immunity 2009 May;77(5):1734-45
Infection and immunity 2009 May;77(5):1734-45
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse thymus tissue were subjected to SDS PAGE followed by western blot with 11214-1-AP(PTPN2 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PTPN2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PTPN2. This antibody recognizes human, mouse antigen. The PTPN2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.