14906-1-AP

antibody from Proteintech Group

Targeting: FADD GIG3, MORT1

Provider product page for 14906-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [63]
Comments [0]
Validations
Western blot [1]
Immunoprecipitation [1]
Immunohistochemistry [2]

Submit

Product number: 14906-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14906-1-AP, RRID:AB_2100486
Product name: FADD antibody
Antibody type: Polyclonal
Description: FADD antibody (Cat. #14906-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

FADD protein structure - 14906-1-AP shown in red.

Submitted references NLK facilitates Caspase-8 activation to drive macrophage PANoptosis in sepsis.

Xia Y, Yao RQ, Liu HF, Jing GQ, Aidebaike D, Zuo J, Wan SQ, Wu D, Zhao PY, Gong HL, Wang X, Zhou HM, Dong N, Wu Y, Liu S, Wu XJ, Yao YM, Song XM
Clinical and translational medicine 2026 Feb;16(2):e70616

Curcumol alleviates endometriosis via correcting the aberrant activation of Fas/RIPK1-mediated PANoptosis.

Ni W, Wu X, Feng L, Xu M, Tian Y
Frontiers in pharmacology 2025;16:1691279

Acetylated Dendrobium huoshanense polysaccharide: a novel inducer of apoptosis in colon cancer cells via Fas-FasL pathway activation and metabolic reprogramming.

Yao L, Gu C, Ge R, Zhang X, Meng X, Wang L, Peng D, Li G
Frontiers in oncology 2025;15:1529868

Caspase-8 drove apoptosis of BMECs to promote neutrophil infiltration and DE205B clearance in meningitis.

Wang X, Lin W, Ye L, Chen X, Ren J, Xue F, Dai J, Tang F
Microbiological research 2025 Sep;298:128223

Active compounds of licorice ameliorate microplastics-induced intestinal damage by targeting FADD.

Xue W, Fan X, Hui Y, Yu J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115570

Evaluation of PANoptosis activation in irreversible pulpitis: An in vitro study based on human tissue samples.

Yang B, Fu Y, Lai L, He J, Li X, Hou J
Archives of oral biology 2025 Sep;177:106305

Ampelopsis grossedentata protects against ethanol-induced acute duodenal injury by inhibiting TNF-triggered caspases-dependent apoptosis in mice.

Sun CY, Li WQ, Lu JW, Zhang AY, Chu QX, Tang L, Gao W, Cai JJ, Lu Y, Liu D
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120462

CPNE5 overexpression inhibits cardiomyocytes apoptosis by promoting the degradation of FAS receptor.

Zhao T, Bai Y, Fei Y, Wei Z, Yao P, Che Q, Zhang Y, Yan J, Chen K, Wu Z, Qiu J, Wang Y, Li W, Wang Q, Li Y
iScience 2025 Sep 19;28(9):113302

MicroRNA-106a regulates the apoptosis and oxidative stress of porcine trabecular meshwork cells by targeting FAS.

Lai J, Tan C, Qiao Y, Sun X, Chen J
Experimental eye research 2025 May;254:110313

Multi-omics revealed activation of TNF-α induced apoptosis signaling pathway in testis of DEHP treated prepubertal male rat.

Fang Z, Jin Z, Zhao Q, Weng J, Zhang Z, Yang Y, Jiang H
Reproductive toxicology (Elmsford, N.Y.) 2025 Mar;132:108758

Ionized Angelica polysaccharides derivatives slow tumor growth in vivo and induce the apoptosis of HepG2 cells via mitochondria death receptor-mediated pathways in vitro.

Yang Y, Wang J, Zhang Y, Xue W, Chen Y, Yue J, Wen Y, Feng R, Tan C
International journal of biological macromolecules 2025 Jun;315(Pt 1):144297

Ilicicolin C suppresses the progression of prostate cancer by inhibiting PI3K/AKT/mTOR pathway.

Gan X, Luo X, Chen J, Fang W, Nie M, Lu H, Liu Y, Wang X
Molecular and cellular biochemistry 2025 Feb;480(2):1089-1104

Hypoxia-mediated SUMOylation of FADD exacerbates endothelial cell injury via the RIPK1-RIPK3-MLKL signaling axis.

Yang L, Wen Y, Yuan Z, Zhao D, Weng P, Li Y, Chen Q, Zhang W, Hu H, Yu C
Cell death & disease 2025 Feb 21;16(1):121

Ox-LDL Induces Neuron Apoptosis and Worsens Neurological Outcomes in aSAH via Fas/FADD Pathway.

Song Y, Yu C, Bo D, Sun J, Wang Y, Chen P, Wu H, Hong L, Ye Z, Zhang L, Zhou D
Molecular neurobiology 2025 Aug;62(8):10296-10309

MLCK inhibition induces synthetic lethality in MYC-driven cancer.

Sun Z, Wu R, Liang X, Shi T, Zhang Y, Pan Z, Zhang W, Luan X
Cancer letters 2025 Aug 10;625:217803

Mitochondrial Dysfunction by FADDosome Promotes Gastric Mucosal Injury in Portal Hypertensive Gastropathy.

Xiao Y, Zhang Y, Xie K, Huang X, Liu X, Luo J, Tan S
International journal of biological sciences 2024;20(7):2658-2685

FADD promotes type I interferon production to suppress porcine reproductive and respiratory syndrome virus infection.

Chang X, Wang M, Li Z, Wang L, Zhang G, Chang Y, Hu J
Frontiers in veterinary science 2024;11:1380144

Deubiquitinase USP5 regulates RIPK1 driven pyroptosis in response to myocardial ischemic reperfusion injury.

Sun W, Lu H, Ma L, Ding C, Wang H, Chu Y
Cell communication and signaling : CCS 2024 Sep 30;22(1):466

LncRNA H19/miR-107 regulates endothelial progenitor cell pyroptosis and promotes flow recovery of lower extremity ischemia through targeting FADD.

Huang L, Ye Y, Sun Y, Zhou Z, Deng T, Liu Y, Wu R, Wang K, Yao C
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167323

Buyang huanwu decoction alleviates stroke-induced immunosuppression in MCAO mice by reducing splenic T cell apoptosis triggered by AIM2 inflammasome.

Fu R, Guo Y, Zhao L, Cheng X, Qin X, Xu W, Zhang Y, Shi R, Zhang Z, Xu S
Journal of ethnopharmacology 2024 Oct 28;333:118474

Dingxian pill alleviates hippocampal neuronal apoptosis in epileptic mice through TNF-α/TNFR1 signaling pathway inhibition.

Wang Q, Qin B, Yu H, Yu H, Zhang X, Li M, Zhou Y, Diao L, Liu H
Journal of ethnopharmacology 2024 Nov 15;334:118579

Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency.

Oda H, Manthiram K, Chavan PP, Rieser E, Veli Ö, Kaya Ö, Rauch C, Nakabo S, Kuehn HS, Swart M, Wang Y, Çelik NI, Molitor A, Ziaee V, Movahedi N, Shahrooei M, Parvaneh N, Alipour-Olyei N, Carapito R, Xu Q, Preite S, Beck DB, Chae JJ, Nehrebecky M, Ombrello AK, Hoffmann P, Romeo T, Deuitch NT, Matthíasardóttir B, Mullikin J, Komarow H, Stoddard J, Niemela J, Dobbs K, Sweeney CL, Anderton H, Lawlor KE, Yoshitomi H, Yang D, Boehm M, Davis J, Mudd P, Randazzo D, Tsai WL, Gadina M, Kaplan MJ, Toguchida J, Mayer CT, Rosenzweig SD, Notarangelo LD, Iwai K, Silke J, Schwartzberg PL, Boisson B, Casanova JL, Bahram S, Rao AP, Peltzer N, Walczak H, Lalaoui N, Aksentijevich I, Kastner DL
Nature immunology 2024 May;25(5):764-777

TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.

Deng B, Wang J, Yang T, Deng Z, Yuan J, Zhang B, Zhou Z, Chen F, Fang L, Liang C, Yan B, Ai Y
The Journal of cell biology 2024 Mar 4;223(3)

Co-exposure of microcystin and nitrite enhanced spermatogenic disorders: The role of mtROS-mediated pyroptosis and apoptosis.

Liu H, Du X, Zhang Z, Ge K, Chen X, Losiewicz MD, Guo H, Zhang H
Environment international 2024 Jun;188:108771

ZBP1-mediated PANoptosis: A possible novel mechanism underlying the therapeutic effects of penehyclidine hydrochloride on myocardial ischemia-reperfusion injury.

Cui B, Qi Z, Liu W, Zhang G, Lin D
International immunopharmacology 2024 Aug 20;137:112373

MiR-21 attenuates FAS-mediated cardiomyocyte apoptosis by regulating HIPK3 expression.

Wang X, Zhang T, Zhai J, Wang Z, Wang Y, He L, Ma S, Xing H, Guo Y
Bioscience reports 2023 Sep 27;43(9)

Identification of A novel anoikis-related genes-based signature for non-small cell lung cancer.

Lei J, Guo G, Liang D, Gong L, Zhang L, Wang X
Biochemical and biophysical research communications 2023 Sep 17;673:137-144

Quizartinib inhibits necroptosis by targeting receptor-interacting serine/threonine protein kinase 1.

Li M, Wei J, Zhu G, Fu S, He X, Hu X, Yu Y, Mou Y, Wang J, You X, Xiao X, Gu T, Ye Z, Zha Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23178

PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism.

Lin H, Han H, Yang M, Wen Z, Chen Q, Ma Y, Wang X, Wang C, Yin T, Wang X, Lu G, Chen H, Qi J, Yang Y
European journal of medicinal chemistry 2023 Mar 5;249:115166

Low-density small extracellular vesicles in bovine follicular fluid carrying let-7i target FASLG to inhibit granulosa cells apoptosis.

Zhao Y, Wang Y, Ling Z, Xue Y, Luan D, Kang J, Zhang Y, Quan F
Theriogenology 2023 Mar 15;199:121-130

Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.

Wang W, Gu Y, Ni H, Quan Q, Guo L
Experimental biology and medicine (Maywood, N.J.) 2023 Jun;248(12):1043-1055

Effects of Treadmill Exercise on Liver Apoptosis in Fluoride-Exposed Mice.

Liu K, Chai L, Zhao T, Zhang S, Wang J, Yu Y, Niu R, Sun Z
Biological trace element research 2023 Dec;201(12):5734-5746

EGFR-TNFR1 pathway in endothelial cell facilitates acute lung injury by NF-κB/MAPK-mediated inflammation and RIP3-dependent necroptosis.

Zhang H, Zhang X, Ling C, Liu C, Hua S, Xiong Z, Zhao H, Feng Q, Feng Z, Tang J, Hong X
International immunopharmacology 2023 Apr;117:109902

Structural Characterization and Anti-breast Cancer Activity in vitro of a Novel Polysaccharide From Cymbopogon citratus.

Chen Y, Qiao S, Liu H, Xing H, Chen P
Frontiers in nutrition 2022;9:911838

Fructose Induces Insulin Resistance of Gestational Diabetes Mellitus in Mice via the NLRP3 Inflammasome Pathway.

Liu Y, Wei Y, Wu L, Lin X, Sun R, Chen H, Shen S, Deng G
Frontiers in nutrition 2022;9:839174

Mannan-Binding Lectin Deficiency Limits Inflammation-induced Myeloid-Derived Suppressor Cells Expansion via Modulating Tumor Necrosis Factor Alpha-triggered Apoptosis.

Dong L, Jiang H, Chen K, Xie J, An Q, Deng F, Sun Z, Liu Y, Zhou J, Zhang L, Lu X, Wang M, Chen Z, Zou X, Zuo D
International journal of biological sciences 2022;18(4):1580-1593

A causal variant rs3769823 in 2q33.1 involved in apoptosis pathway leading to a decreased risk of non-small cell lung cancer.

Zhang X, Qin N, Fan J, Zhang C, Sun Q, Gu Y, Zhu M, Zhang E, Dai J, Jin G, Ma H, Hu Z, Shen H
Cancer biology & medicine 2022 Sep 2;19(9):1385-96

Astragaloside IV Inhibits the Proliferation of Human Uterine Leiomyomas by Targeting IDO1.

Qiu T, Li D, Liu Y, Ren H, Yang X, Luo W
Cancers 2022 Sep 12;14(18)

N-acetylserotonin protects PC12 cells from hydrogen peroxide induced damage through ROS mediated PI3K / AKT pathway.

Kang J, Wang Y, Guo X, He X, Liu W, Chen H, Wang Z, Lin A, Kang X
Cell cycle (Georgetown, Tex.) 2022 Nov;21(21):2268-2282

Human breast milk-derived exosomes through inhibiting AT II cell apoptosis to prevent bronchopulmonary dysplasia in rat lung.

Zhou Y, Liu Y, Xu G, Liu L, Li H, Li Y, Yin J, Wang X, Yu Z
Journal of cellular and molecular medicine 2022 Aug;26(15):4169-4182

Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy.

Miyashita H, Oikawa D, Terawaki S, Kabata D, Shintani A, Tokunaga F
Frontiers in immunology 2021;12:635475

The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8.

Zhang JY, Zhou B, Sun RY, Ai YL, Cheng K, Li FN, Wang BR, Liu FJ, Jiang ZH, Wang WJ, Zhou D, Chen HZ, Wu Q
Cell research 2021 Sep;31(9):980-997

MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIP(L).

Nakabayashi O, Takahashi H, Moriwaki K, Komazawa-Sakon S, Ohtake F, Murai S, Tsuchiya Y, Koyahara Y, Saeki Y, Yoshida Y, Yamazaki S, Tokunaga F, Sawasaki T, Nakano H
Communications biology 2021 Jan 19;4(1):80

Calcium alleviates fluoride-induced kidney damage via FAS/FASL, TNFR/TNF, DR5/TRAIL pathways in rats.

Li H, Fan J, Zhao Y, Yang J, Xu H, Manthari RK, Cheng X, Wang J, Wang J
Ecotoxicology and environmental safety 2021 Dec 15;226:112851

Nuclear respiratory factor 1 protects H9C2 cells against hypoxia-induced apoptosis via the death receptor pathway and mitochondrial pathway.

Li H, Niu N, Yang J, Dong F, Zhang T, Li S, Zhao W
Cell biology international 2021 Aug;45(8):1784-1796

A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5.

Zhang Y, Huang K, Zhang Y, Han T, Li L, Ruan C, Sun YH, Shi W, Han W, Wu SQ, Song J, Liu J, Han J
PLoS biology 2021 Aug;19(8):e3001304

ROS-mediated PERK-eIF2α-ATF4 pathway plays an important role in arsenite-induced L-02 cells apoptosis via regulating CHOP-DR5 signaling.

Liu C, Zhang A
Environmental toxicology 2020 Oct;35(10):1100-1113

Protective effect of astaxanthin against SnS(2) nanoflowers induced testes toxicity by suppressing RIPK1-RIPK3-MLKL signaling in mice.

Yuan L, Liang P, Qu Y, An T, Wang J, Deng X, Bai L, Shen P, Bai D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Nov;145:111736

Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA.

Liu X, Zhang Y, Wu S, Xu M, Shen Y, Yu M, Fan J, Wei S, Xu C, Huang L, Zhao H, Li X, Ye X
Biochemical pharmacology 2020 May;175:113933

Hic-5 deficiency attenuates hepatic ischemia reperfusion injury through TLR4/NF-κB signaling pathways.

Gao L, Qian B, Chen H, Wang A, Li Q, Li J, Tan P, Xia X, Du Y, Fu W
Life sciences 2020 May 15;249:117517

Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.

Zhao Q, Zhu HP, Xie X, Mao Q, Liu YQ, He XH, Peng C, Jiang QL, Huang W
International journal of molecular sciences 2020 Mar 7;21(5)

Synergetic inhibition of daidzein and regular exercise on breast cancer in bearing-4T1 mice by regulating NK cells and apoptosis pathway.

Wang B, Xu H, Hu X, Ma W, Zhang J, Li Y, Yu M, Zhang Y, Li X, Ye X
Life sciences 2020 Mar 15;245:117387

Aconitine induces cardiomyocyte damage by mitigating BNIP3-dependent mitophagy and the TNFα-NLRP3 signalling axis.

Peng F, Zhang N, Wang C, Wang X, Huang W, Peng C, He G, Han B
Cell proliferation 2020 Jan;53(1):e12701

Long noncoding RNA UBE2R2-AS1 promotes glioma cell apoptosis via targeting the miR-877-3p/TLR4 axis.

Xu W, Hu GQ, Da Costa C, Tang JH, Li QR, Du L, Pan YW, Lv SQ
OncoTargets and therapy 2019;12:3467-3480

SPOP inhibits mice pancreatic stellate cell activation by promoting FADD degradation in cerulein-induced chronic pancreatitis.

Tan P, Wang A, Chen H, Du Y, Qian B, Shi H, Zhang Y, Xia X, Fu W
Experimental cell research 2019 Nov 1;384(1):111606

Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLAR(L) and inhibit apoptosis in human non-small cell lung cancer cells.

An W, Yao S, Sun X, Hou Z, Lin Y, Su L, Liu X
Journal of experimental & clinical cancer research : CR 2019 May 2;38(1):181

A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer.

Zhan Y, Zhang H, Dai B, Zhang Y, Zhang J, He L
Oncology reports 2018 Aug;40(2):1064-1072

Protective effect of mild-induced hypothermia against moderate traumatic brain injury in rats involved in necroptotic and apoptotic pathways.

Zhang HB, Cheng SX, Tu Y, Zhang S, Hou SK, Yang Z
Brain injury 2017;31(3):406-415

Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways.

Jiang Z, Song F, Li Y, Xue D, Zhao N, Zhang J, Deng G, Li M, Liu X, Wang Y
Oxidative medicine and cellular longevity 2017;2017:6175841

TRAIL Deletion Prevents Liver, but Not Adipose Tissue, Inflammation during Murine Diet-Induced Obesity.

Hirsova P, Weng P, Salim W, Bronk SF, Griffith TS, Ibrahim SH, Gores GJ
Hepatology communications 2017 Sep;1(7):648-662

Non-hemolytic enterotoxin of Bacillus cereus induces apoptosis in Vero cells.

Liu X, Ding S, Shi P, Dietrich R, Märtlbauer E, Zhu K
Cellular microbiology 2017 Apr;19(4)

Dynamic quantitative proteomics characterization of TNF-α-induced necroptosis.

Wang Y, Huang ZH, Li YJ, He GW, Yu RY, Yang J, Liu WT, Li B, He QY
Apoptosis : an international journal on programmed cell death 2016 Dec;21(12):1438-1446

miR-155 inhibits oxidized low-density lipoprotein-induced apoptosis of RAW264.7 cells.

Zhu GF, Yang LX, Guo RW, Liu H, Shi YK, Wang H, Ye JS, Yang ZH, Liang X
Molecular and cellular biochemistry 2013 Oct;382(1-2):253-61

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HT-1080 cells were subjected to SDS PAGE followed by western blot with 14906-1-AP( FADD Antibody) at dilution of 1:300
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-FADD (IP:14906-1-AP, 3ug; Detection:14906-1-AP 1:200) with A549 cells lysate 1200ug.
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human lung cancer using 14906-1-AP(FADD antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The FADD antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FADD. This antibody recognizes human,mouse,rat antigen. The FADD antibody has been validated for the following applications: ELISA, IHC, IP, WB analysis.
Appendix: 14906-1-AP.pdf

: Show more