Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations [0]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 60153PE - Provider product page
- Provider
- STEMCELL Technologies Inc
- Product name
- Anti-Human CD25 Antibody, Clone 2A3, PE
- Antibody type
- Monoclonal
- Description
- The 2A3 antibody reacts with human CD25, a 55 kDa type I integral transmembrane glycoprotein also known as low-affinity interleukin 2 receptor alpha chain (IL-2R?) or Tac antigen. CD25 is present on activated T and B cells, monocytes, macrophages, and regulatory T cells. CD25 has role in T lymphocyte activations and identification of T cell subsets in viral infections like HIV and HTLV. CD25 associates with IL-2 receptor ? (CD122) and common ? (CD132) chains to form a high affinity IL-2R complex. The 2A3 antibody binds to an epitope on p55 at or near the IL-2 binding site and prevents high-affinity IL-2 binding to T lymphocytes. Daclizumab, a therapeutic humanised monoclonal antibody, blocks the binding of 2A3 antibody.
- Reactivity
- Human
- Host
- Human
- Isotype
- IgG
- Vial size
- 50 Tests
- Storage
- 2 - 8°C
No comments: Submit comment
No validations: Submit validation data