ABIN968245

antibody from antibodies-online

Targeting: NCF2 NOXA2, p67phox

Western blot (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Antibody Data

Product number

ABIN968245

Provider

antibodies-online

Product name

anti-Neutrophil Cytosolic Factor 2 (NCF2) (AA 317-469) antibody

Antibody type

Monoclonal

Antigen

Human p67 [phox]

Reactivity

Human

Host

Mouse

Isotype

IgG

Antibody clone number

29

Vial size

50 µg

Concentration

250 µg/ml

Storage

Store undiluted at -20° C.

References

Submitted references

Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47(phox). Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby activating the oxidase.

Ago T, Nunoi H, Ito T, Sumimoto H
The Journal of biological chemistry 1999 Nov 19;274(47):33644-53

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Phosphorylation of the respiratory burst oxidase subunit p67(phox) during human neutrophil activation. Regulation by protein kinase C-dependent and independent pathways.

Benna JE, Dang PM, Gaudry M, Fay M, Morel F, Hakim J, Gougerot-Pocidalo MA
The Journal of biological chemistry 1997 Jul 4;272(27):17204-8

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NADPH oxidase activity is independent of p47phox in vitro.

Freeman JL, Lambeth JD
The Journal of biological chemistry 1996 Sep 13;271(37):22578-82

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Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets.

Leto TL, Adams AG, de Mendez I
Proceedings of the National Academy of Sciences of the United States of America 1994 Oct 25;91(22):10650-4

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Cloning of a 67-kD neutrophil oxidase factor with similarity to a noncatalytic region of p60c-src.

Leto TL, Lomax KJ, Volpp BD, Nunoi H, Sechler JM, Nauseef WM, Clark RA, Gallin JI, Malech HL
Science (New York, N.Y.) 1990 May 11;248(4956):727-30