Antibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 12695-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12695-1-AP, RRID:AB_2136253
- Product name
- LIG4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated LIG4 antibody (Cat. #12695-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references C9orf72 functions in the nucleus to regulate DNA damage repair.
Antitumor efficacy of a recombinant EGFR-targeted fusion protein conjugate that induces telomere shortening and telomerase downregulation.
CSB Regulates Pathway Choice in Response to DNA Replication Stress Induced by Camptothecin.
Comparison of DNA stability and its related genes of neurons derived from induced pluripotent stem cells and primary retinal neurons.
Inhibition of ATM Induces Hypersensitivity to Proton Irradiation by Upregulating Toxic End Joining.
CRISPR/Cas9 library screening uncovered methylated PKP2 as a critical driver of lung cancer radioresistance by stabilizing β-catenin.
Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling.
Long noncoding RNA lnc-RI regulates DNA damage repair and radiation sensitivity of CRC cells through NHEJ pathway.
MiR-1587 Regulates DNA Damage Repair and the Radiosensitivity of CRC Cells via Targeting LIG4.
MiR-34s negatively regulate homologous recombination through targeting RAD51.
RNase L facilitates the repair of DNA double-strand breaks through the nonhomologous end-joining pathway.
Retinal Neuron Is More Sensitive to Blue Light-Induced Damage than Glia Cell Due to DNA Double-Strand Breaks.
Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy.
XRCC4, which is inhibited by PFDA, regulates DNA damage repair and cell chemosensitivity.
Exosome-packaged miR-1246 contributes to bystander DNA damage by targeting LIG4.
Berberine activates caspase-9/cytochrome c-mediated apoptosis to suppress triple-negative breast cancer cells in vitro and in vivo.
XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency.
Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.
Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway.
Regenerative capacity of old muscle stem cells declines without significant accumulation of DNA damage.
Differences in sensitivity to DNA-damaging Agents between XRCC4- and Artemis-deficient human cells.
Cellular DNA ligase I is recruited to cytoplasmic vaccinia virus factories and masks the role of the vaccinia ligase in viral DNA replication.
He L, Liang J, Chen C, Chen J, Shen Y, Sun S, Li L
Cell death and differentiation 2023 Mar;30(3):716-730
Cell death and differentiation 2023 Mar;30(3):716-730
Antitumor efficacy of a recombinant EGFR-targeted fusion protein conjugate that induces telomere shortening and telomerase downregulation.
Tao HY, He SM, Zhao CY, Wang Y, Sheng WJ, Zhen YS
International journal of biological macromolecules 2023 Jan 31;226:1088-1099
International journal of biological macromolecules 2023 Jan 31;226:1088-1099
CSB Regulates Pathway Choice in Response to DNA Replication Stress Induced by Camptothecin.
Batenburg NL, Walker JR, Zhu XD
International journal of molecular sciences 2023 Aug 4;24(15)
International journal of molecular sciences 2023 Aug 4;24(15)
Comparison of DNA stability and its related genes of neurons derived from induced pluripotent stem cells and primary retinal neurons.
Yu N, Qiu J, Li K, Luo Q, Liu X, Yang Y, Jiang Z, He S, He A, Chen S, Chen X, Li Y, Ge J, Zhuang J, Yu K
Cell biology international 2022 Oct;46(10):1625-1636
Cell biology international 2022 Oct;46(10):1625-1636
Inhibition of ATM Induces Hypersensitivity to Proton Irradiation by Upregulating Toxic End Joining.
Zhou Q, Howard ME, Tu X, Zhu Q, Denbeigh JM, Remmes NB, Herman MG, Beltran CJ, Yuan J, Greipp PT, Boughey JC, Wang L, Johnson N, Goetz MP, Sarkaria JN, Lou Z, Mutter RW
Cancer research 2021 Jun 15;81(12):3333-3346
Cancer research 2021 Jun 15;81(12):3333-3346
CRISPR/Cas9 library screening uncovered methylated PKP2 as a critical driver of lung cancer radioresistance by stabilizing β-catenin.
Cheng C, Pei X, Li SW, Yang J, Li C, Tang J, Hu K, Huang G, Min WP, Sang Y
Oncogene 2021 Apr;40(16):2842-2857
Oncogene 2021 Apr;40(16):2842-2857
Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling.
Guo G, Gao M, Gao X, Zhu B, Huang J, Tu X, Kim W, Zhao F, Zhou Q, Zhu S, Wu Z, Yan Y, Zhang Y, Zeng X, Zhu Q, Yin P, Luo K, Sun J, Deng M, Lou Z
Nature communications 2021 Apr 12;12(1):2187
Nature communications 2021 Apr 12;12(1):2187
Long noncoding RNA lnc-RI regulates DNA damage repair and radiation sensitivity of CRC cells through NHEJ pathway.
Liu R, Zhang Q, Shen L, Chen S, He J, Wang D, Wang Q, Qi Z, Zhou M, Wang Z
Cell biology and toxicology 2020 Oct;36(5):493-507
Cell biology and toxicology 2020 Oct;36(5):493-507
MiR-1587 Regulates DNA Damage Repair and the Radiosensitivity of CRC Cells via Targeting LIG4.
Liu R, Shen L, Lin C, He J, Wang Q, Qi Z, Zhang Q, Zhou M, Wang Z
Dose-response : a publication of International Hormesis Society 2020 Apr-Jun;18(2):1559325820936906
Dose-response : a publication of International Hormesis Society 2020 Apr-Jun;18(2):1559325820936906
MiR-34s negatively regulate homologous recombination through targeting RAD51.
Chen S, Liu R, Wang Q, Qi Z, Hu Y, Zhou P, Wang Z
Archives of biochemistry and biophysics 2019 May 15;666:73-82
Archives of biochemistry and biophysics 2019 May 15;666:73-82
RNase L facilitates the repair of DNA double-strand breaks through the nonhomologous end-joining pathway.
Zhong Y, Pan B, Zhu J, Fu H, Zheng X
FEBS letters 2019 Jun;593(11):1190-1200
FEBS letters 2019 Jun;593(11):1190-1200
Retinal Neuron Is More Sensitive to Blue Light-Induced Damage than Glia Cell Due to DNA Double-Strand Breaks.
Chen P, Lai Z, Wu Y, Xu L, Cai X, Qiu J, Yang P, Yang M, Zhou P, Zhuang J, Ge J, Yu K, Zhuang J
Cells 2019 Jan 18;8(1)
Cells 2019 Jan 18;8(1)
Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy.
Khattar E, Maung KZY, Chew CL, Ghosh A, Mok MMH, Lee P, Zhang J, Chor WHJ, Cildir G, Wang CQ, Mohd-Ismail NK, Chin DWL, Lee SC, Yang H, Shin YJ, Nam DH, Chen L, Kumar AP, Deng LW, Ikawa M, Gunaratne J, Osato M, Tergaonkar V
Nature communications 2019 Dec 13;10(1):5349
Nature communications 2019 Dec 13;10(1):5349
XRCC4, which is inhibited by PFDA, regulates DNA damage repair and cell chemosensitivity.
Liu F, Fan Z, Song N, Han M, Yan M, Guo LH, Jihui J, Liu S
Journal of cellular biochemistry 2019 Aug;120(8):12665-12676
Journal of cellular biochemistry 2019 Aug;120(8):12665-12676
Exosome-packaged miR-1246 contributes to bystander DNA damage by targeting LIG4.
Mo LJ, Song M, Huang QH, Guan H, Liu XD, Xie DF, Huang B, Huang RX, Zhou PK
British journal of cancer 2018 Aug;119(4):492-502
British journal of cancer 2018 Aug;119(4):492-502
Berberine activates caspase-9/cytochrome c-mediated apoptosis to suppress triple-negative breast cancer cells in vitro and in vivo.
Zhao Y, Jing Z, Lv J, Zhang Z, Lin J, Cao X, Zhao Z, Liu P, Mao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Nov;95:18-24
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Nov;95:18-24
XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency.
Guo C, Nakazawa Y, Woodbine L, Björkman A, Shimada M, Fawcett H, Jia N, Ohyama K, Li TS, Nagayama Y, Mitsutake N, Pan-Hammarström Q, Gennery AR, Lehmann AR, Jeggo PA, Ogi T
The Journal of allergy and clinical immunology 2015 Oct;136(4):1007-17
The Journal of allergy and clinical immunology 2015 Oct;136(4):1007-17
Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.
Dong H, Shi Q, Song X, Fu J, Hu L, Xu D, Su C, Xia X, Song E, Song Y
Toxicology and applied pharmacology 2015 Jul 1;286(1):10-6
Toxicology and applied pharmacology 2015 Jul 1;286(1):10-6
Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway.
Xing M, Yang M, Huo W, Feng F, Wei L, Jiang W, Ning S, Yan Z, Li W, Wang Q, Hou M, Dong C, Guo R, Gao G, Ji J, Zha S, Lan L, Liang H, Xu D
Nature communications 2015 Feb 11;6:6233
Nature communications 2015 Feb 11;6:6233
Regenerative capacity of old muscle stem cells declines without significant accumulation of DNA damage.
Cousin W, Ho ML, Desai R, Tham A, Chen RY, Kung S, Elabd C, Conboy IM
PloS one 2013;8(5):e63528
PloS one 2013;8(5):e63528
Differences in sensitivity to DNA-damaging Agents between XRCC4- and Artemis-deficient human cells.
Katsube T, Mori M, Tsuji H, Shiomi T, Shiomi N, Onoda M
Journal of radiation research 2011;52(4):415-24
Journal of radiation research 2011;52(4):415-24
Cellular DNA ligase I is recruited to cytoplasmic vaccinia virus factories and masks the role of the vaccinia ligase in viral DNA replication.
Paran N, De Silva FS, Senkevich TG, Moss B
Cell host & microbe 2009 Dec 17;6(6):563-9
Cell host & microbe 2009 Dec 17;6(6):563-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse testis tissue were subjected to SDS PAGE followed by western blot with 12695-1-AP(LIG4 antibody) at dilution of 1:600
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The LIG4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human LIG4. This antibody recognizes human, mouse antigen. The LIG4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.