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Targeting: MRE11
ATLD, MRE11A
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ELISA Immunocytochemistry Immunoprecipitation Immunohistochemistry Functional assay Proximity ligation assayAntibody data
- Antibody Data
- Antigen structure
- References [137]
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- Western blot [8]
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- Product number
- GTX70212 - Provider product page
- Provider
- GeneTex
- Proper citation
- GeneTex Cat#GTX70212, RRID:AB_372398
- Product name
- Mre11 antibody [12D7]
- Antibody type
- Monoclonal
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
Submitted references Inhibiting homologous recombination decreases extrachromosomal amplification but has no effect on intrachromosomal amplification in methotrexate-resistant colon cancer cells.
Mechanism of Adenovirus E4-ORF3-Mediated SUMO Modifications.
Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks.
Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells.
CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress.
β1-Integrin Impacts Rad51 Stability and DNA Double-Strand Break Repair by Homologous Recombination.
Therapeutic Effect of Quinacrine, an Antiprotozoan Drug, by Selective Suppression of p-CHK1/2 in p53-Negative Malignant Cancers.
Homeodomain Proteins Directly Regulate ATM Kinase Activity.
Precise and Predictable CRISPR Chromosomal Rearrangements Reveal Principles of Cas9-Mediated Nucleotide Insertion.
Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.
AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway.
Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus.
Differentiation of Human Induced Pluripotent or Embryonic Stem Cells Decreases the DNA Damage Repair by Homologous Recombination.
DEK is required for homologous recombination repair of DNA breaks.
The Rb binding domain of HPV31 E7 is required to maintain high levels of DNA repair factors in infected cells.
Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling.
MCL-1 Depletion Impairs DNA Double-Strand Break Repair and Reinitiation of Stalled DNA Replication Forks.
Reactive Oxygen Species (ROS)-Activated ATM-Dependent Phosphorylation of Cytoplasmic Substrates Identified by Large-Scale Phosphoproteomics Screen.
Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells.
An Intrinsically Disordered Region of the DNA Repair Protein Nbs1 Is a Species-Specific Barrier to Herpes Simplex Virus 1 in Primates.
Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair.
ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.
The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers.
Activation of DNA Damage Response Pathways during Lytic Replication of KSHV.
FGFR2 regulates Mre11 expression and double-strand break repair via the MEK-ERK-POU1F1 pathway in breast tumorigenesis.
NKX3.1 Suppresses TMPRSS2-ERG Gene Rearrangement and Mediates Repair of Androgen Receptor-Induced DNA Damage.
Nonlinear ionizing radiation-induced changes in eye lens cell proliferation, cyclin D1 expression and lens shape.
Activity of CEP-9722, a poly (ADP-ribose) polymerase inhibitor, in urothelial carcinoma correlates inversely with homologous recombination repair response to DNA damage.
BRCA1 haploinsufficiency for replication stress suppression in primary cells.
Protective role of RAD50 on chromatin bridges during abnormal cytokinesis.
Functional deficiency of NBN, the Nijmegen breakage syndrome protein, in a p.R215W mutant breast cancer cell line.
Quantitation of DNA double-strand break resection intermediates in human cells.
Distinct functions of human cohesin-SA1 and cohesin-SA2 in double-strand break repair.
Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1.
Two sequential cleavage reactions on cruciform DNA structures cause palindrome-mediated chromosomal translocations.
Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.
A patient-derived olfactory stem cell disease model for ataxia-telangiectasia.
Host DNA damage response facilitates African swine fever virus infection.
Adenovirus regulates sumoylation of Mre11-Rad50-Nbs1 components through a paralog-specific mechanism.
A requirement for polymerized actin in DNA double-strand break repair.
Discordance between phosphorylation and recruitment of 53BP1 in response to DNA double-strand breaks.
Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions.
ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.
Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway.
NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis.
Novel regulatory role for Kaposi's sarcoma-associated herpesvirus-encoded vFLIP in chemosensitization to bleomycin.
Adenovirus core protein VII protects the viral genome from a DNA damage response at early times after infection.
Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection.
Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly.
Autophosphorylation and ATM activation: additional sites add to the complexity.
Human T-lymphotropic type 1 virus p30 inhibits homologous recombination and favors unfaithful DNA repair.
Bocavirus infection induces a DNA damage response that facilitates viral DNA replication and mediates cell death.
CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors.
The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection.
Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication.
Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response.
Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex.
Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex.
ATM activation in the presence of oxidative stress.
ATM activation in the presence of oxidative stress.
Unique DNA repair gene variations and potential associations with the primary antibody deficiency syndromes IgAD and CVID.
Adeno-associated virus and adenovirus coinfection induces a cellular DNA damage and repair response via redundant phosphatidylinositol 3-like kinase pathways.
Suppressing the high-level expression and function of ATM in advanced-stage melanomas does not sensitize the cells to ionizing radiation.
Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation.
High resolution imaging of changes in the structure and spatial organization of chromatin, gamma-H2A.X and the MRN complex within etoposide-induced DNA repair foci.
Clinical variability and expression of the NBN c.657del5 allele in Nijmegen Breakage Syndrome.
Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.
Temporal regulation of the Mre11-Rad50-Nbs1 complex during adenovirus infection.
MRE11 complex links RECQ5 helicase to sites of DNA damage.
Altered states of telomere deprotection and the two-stage mechanism of replicative aging.
Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection.
Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase.
DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression.
The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses.
MicroRNA regulation of DNA repair gene expression in hypoxic stress.
MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair.
DNA ligase I and Nbs1 proteins associate in a complex and colocalize at replication factories.
Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation.
A glycine-arginine domain in control of the human MRE11 DNA repair protein.
Characterization of mre11 loss following HSV-1 infection.
DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B.
PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites.
Processing of recombinant AAV genomes occurs in specific nuclear structures that overlap with foci of DNA-damage-response proteins.
Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells.
The effects of 41 degrees C hyperthermia on the DNA repair protein, MRE11, correlate with radiosensitization in four human tumor cell lines.
Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes.
Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone.
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.
Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export.
Cancer incidence in Nijmegen breakage syndrome is modulated by the amount of a variant NBS protein.
The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication.
Mre11 expression in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
Inhibition of hsp90 compromises the DNA damage response to radiation.
FLASH is required for histone transcription and S-phase progression.
FLASH is an essential component of Cajal bodies.
Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
DDB1 maintains genome integrity through regulation of Cdt1.
Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype.
Mild Nijmegen breakage syndrome phenotype due to alternative splicing.
The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres.
Involvement of novel autophosphorylation sites in ATM activation.
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks.
hMRE11 deficiency leads to microsatellite instability and defective DNA mismatch repair.
Analysis of ionizing radiation-induced foci of DNA damage repair proteins.
The adenovirus E4orf6 protein inhibits DNA double strand break repair and radiosensitizes human tumor cells in an E1B-55K-independent manner.
Evidence for the direct binding of phosphorylated p53 to sites of DNA breaks in vivo.
Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells.
DNA repair proteins affect the lifecycle of herpes simplex virus 1.
Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.
Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage response.
Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression.
BLM and the FANC proteins collaborate in a common pathway in response to stalled replication forks.
Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forks.
Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability.
Slow progression of ataxia-telangiectasia with double missense and in frame splice mutations.
Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation.
The Mason-Pfizer monkey virus PPPY and PSAP motifs both contribute to virus release.
NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors.
Requirement of the MRN complex for ATM activation by DNA damage.
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage.
NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways.
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.
Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.
MDC1 is a mediator of the mammalian DNA damage checkpoint.
The Mre11 complex is required for ATM activation and the G2/M checkpoint.
Radiosensitization of heat resistant human tumour cells by 1 hour at 41.1 degrees C and its effect on DNA repair.
Evidence for a direct association of hMRE11 with the human mismatch repair protein hMLH1.
DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein.
Specific recruitment of human cohesin to laser-induced DNA damage.
Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex.
UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization.
Interaction of FANCD2 and NBS1 in the DNA damage response.
hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage.
Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome.
ATM-dependent phosphorylation of nibrin in response to radiation exposure.
Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres.
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Cai M, Zhang H, Hou L, Gao W, Song Y, Cui X, Li C, Guan R, Ma J, Wang X, Han Y, Lv Y, Chen F, Wang P, Meng X, Fu S
International journal of cancer 2019 Mar 1;144(5):1037-1048
International journal of cancer 2019 Mar 1;144(5):1037-1048
Mechanism of Adenovirus E4-ORF3-Mediated SUMO Modifications.
Sohn SY, Hearing P
mBio 2019 Feb 26;10(1)
mBio 2019 Feb 26;10(1)
Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks.
Burger K, Schlackow M, Gullerova M
Nucleic acids research 2019 Apr 23;47(7):3467-3484
Nucleic acids research 2019 Apr 23;47(7):3467-3484
Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells.
Fujiwara C, Muramatsu Y, Nishii M, Tokunaka K, Tahara H, Ueno M, Yamori T, Sugimoto Y, Seimiya H
Scientific reports 2018 Oct 4;8(1):14827
Scientific reports 2018 Oct 4;8(1):14827
CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress.
Przetocka S, Porro A, Bolck HA, Walker C, Lezaja A, Trenner A, von Aesch C, Himmels SF, D'Andrea AD, Ceccaldi R, Altmeyer M, Sartori AA
Molecular cell 2018 Nov 1;72(3):568-582.e6
Molecular cell 2018 Nov 1;72(3):568-582.e6
β1-Integrin Impacts Rad51 Stability and DNA Double-Strand Break Repair by Homologous Recombination.
Ahmed KM, Pandita RK, Singh DK, Hunt CR, Pandita TK
Molecular and cellular biology 2018 May 1;38(9)
Molecular and cellular biology 2018 May 1;38(9)
Therapeutic Effect of Quinacrine, an Antiprotozoan Drug, by Selective Suppression of p-CHK1/2 in p53-Negative Malignant Cancers.
Park S, Oh AY, Cho JH, Yoon MH, Woo TG, Kang SM, Lee HY, Jung YJ, Park BJ
Molecular cancer research : MCR 2018 Jun;16(6):935-946
Molecular cancer research : MCR 2018 Jun;16(6):935-946
Homeodomain Proteins Directly Regulate ATM Kinase Activity.
Johnson TE, Lee JH, Myler LR, Zhou Y, Mosley TJ, Yang SH, Bio-Bricks for Molecular Machines FRI Stream, Uprety N, Kim J, Paull TT
Cell reports 2018 Aug 7;24(6):1471-1483
Cell reports 2018 Aug 7;24(6):1471-1483
Precise and Predictable CRISPR Chromosomal Rearrangements Reveal Principles of Cas9-Mediated Nucleotide Insertion.
Shou J, Li J, Liu Y, Wu Q
Molecular cell 2018 Aug 16;71(4):498-509.e4
Molecular cell 2018 Aug 16;71(4):498-509.e4
Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.
Taglialatela A, Alvarez S, Leuzzi G, Sannino V, Ranjha L, Huang JW, Madubata C, Anand R, Levy B, Rabadan R, Cejka P, Costanzo V, Ciccia A
Molecular cell 2017 Oct 19;68(2):414-430.e8
Molecular cell 2017 Oct 19;68(2):414-430.e8
AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway.
Lou J, Chen H, Han J, He H, Huen MSY, Feng XH, Liu T, Huang J
Nature communications 2017 Oct 17;8(1):985
Nature communications 2017 Oct 17;8(1):985
Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus.
Hollingworth R, Horniblow RD, Forrest C, Stewart GS, Grand RJ
Journal of virology 2017 Nov 15;91(22)
Journal of virology 2017 Nov 15;91(22)
Differentiation of Human Induced Pluripotent or Embryonic Stem Cells Decreases the DNA Damage Repair by Homologous Recombination.
Mujoo K, Pandita RK, Tiwari A, Charaka V, Chakraborty S, Singh DK, Hambarde S, Hittelman WN, Horikoshi N, Hunt CR, Khanna KK, Kots AY, Butler EB, Murad F, Pandita TK
Stem cell reports 2017 Nov 14;9(5):1660-1674
Stem cell reports 2017 Nov 14;9(5):1660-1674
DEK is required for homologous recombination repair of DNA breaks.
Smith EA, Gole B, Willis NA, Soria R, Starnes LM, Krumpelbeck EF, Jegga AG, Ali AM, Guo H, Meetei AR, Andreassen PR, Kappes F, Vinnedge LM, Daniel JA, Scully R, Wiesmüller L, Wells SI
Scientific reports 2017 Mar 20;7:44662
Scientific reports 2017 Mar 20;7:44662
The Rb binding domain of HPV31 E7 is required to maintain high levels of DNA repair factors in infected cells.
Johnson BA, Aloor HL, Moody CA
Virology 2017 Jan;500:22-34
Virology 2017 Jan;500:22-34
Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling.
Henrich SM, Usadel C, Werwein E, Burdova K, Janscak P, Ferrari S, Hess D, Klempnauer KH
Scientific reports 2017 Jan 27;7:41663
Scientific reports 2017 Jan 27;7:41663
MCL-1 Depletion Impairs DNA Double-Strand Break Repair and Reinitiation of Stalled DNA Replication Forks.
Mattoo AR, Pandita RK, Chakraborty S, Charaka V, Mujoo K, Hunt CR, Pandita TK
Molecular and cellular biology 2017 Feb 1;37(3)
Molecular and cellular biology 2017 Feb 1;37(3)
Reactive Oxygen Species (ROS)-Activated ATM-Dependent Phosphorylation of Cytoplasmic Substrates Identified by Large-Scale Phosphoproteomics Screen.
Kozlov SV, Waardenberg AJ, Engholm-Keller K, Arthur JW, Graham ME, Lavin M
Molecular & cellular proteomics : MCP 2016 Mar;15(3):1032-47
Molecular & cellular proteomics : MCP 2016 Mar;15(3):1032-47
Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells.
Renaud E, Barascu A, Rosselli F
Nucleic acids research 2016 Jan 29;44(2):648-56
Nucleic acids research 2016 Jan 29;44(2):648-56
An Intrinsically Disordered Region of the DNA Repair Protein Nbs1 Is a Species-Specific Barrier to Herpes Simplex Virus 1 in Primates.
Lou DI, Kim ET, Meyerson NR, Pancholi NJ, Mohni KN, Enard D, Petrov DA, Weller SK, Weitzman MD, Sawyer SL
Cell host & microbe 2016 Aug 10;20(2):178-88
Cell host & microbe 2016 Aug 10;20(2):178-88
Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair.
Nakajima NI, Hagiwara Y, Oike T, Okayasu R, Murakami T, Nakano T, Shibata A
PloS one 2015;10(3):e0122582
PloS one 2015;10(3):e0122582
ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.
Kijas AW, Lim YC, Bolderson E, Cerosaletti K, Gatei M, Jakob B, Tobias F, Taucher-Scholz G, Gueven N, Oakley G, Concannon P, Wolvetang E, Khanna KK, Wiesmüller L, Lavin MF
Nucleic acids research 2015 Sep 30;43(17):8352-67
Nucleic acids research 2015 Sep 30;43(17):8352-67
The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers.
Harten SK, Oey H, Bourke LM, Bharti V, Isbel L, Daxinger L, Faou P, Robertson N, Matthews JM, Whitelaw E
BMC biology 2015 Mar 26;13:21
BMC biology 2015 Mar 26;13:21
Activation of DNA Damage Response Pathways during Lytic Replication of KSHV.
Hollingworth R, Skalka GL, Stewart GS, Hislop AD, Blackbourn DJ, Grand RJ
Viruses 2015 Jun 5;7(6):2908-27
Viruses 2015 Jun 5;7(6):2908-27
FGFR2 regulates Mre11 expression and double-strand break repair via the MEK-ERK-POU1F1 pathway in breast tumorigenesis.
Huang YL, Chou WC, Hsiung CN, Hu LY, Chu HW, Shen CY
Human molecular genetics 2015 Jun 15;24(12):3506-17
Human molecular genetics 2015 Jun 15;24(12):3506-17
NKX3.1 Suppresses TMPRSS2-ERG Gene Rearrangement and Mediates Repair of Androgen Receptor-Induced DNA Damage.
Bowen C, Zheng T, Gelmann EP
Cancer research 2015 Jul 1;75(13):2686-98
Cancer research 2015 Jul 1;75(13):2686-98
Nonlinear ionizing radiation-induced changes in eye lens cell proliferation, cyclin D1 expression and lens shape.
Markiewicz E, Barnard S, Haines J, Coster M, van Geel O, Wu W, Richards S, Ainsbury E, Rothkamm K, Bouffler S, Quinlan RA
Open biology 2015 Apr;5(4):150011
Open biology 2015 Apr;5(4):150011
Activity of CEP-9722, a poly (ADP-ribose) polymerase inhibitor, in urothelial carcinoma correlates inversely with homologous recombination repair response to DNA damage.
Jian W, Xu HG, Chen J, Xu ZX, Levitt JM, Stanley JA, Yang ES, Lerner SP, Sonpavde G
Anti-cancer drugs 2014 Sep;25(8):878-86
Anti-cancer drugs 2014 Sep;25(8):878-86
BRCA1 haploinsufficiency for replication stress suppression in primary cells.
Pathania S, Bade S, Le Guillou M, Burke K, Reed R, Bowman-Colin C, Su Y, Ting DT, Polyak K, Richardson AL, Feunteun J, Garber JE, Livingston DM
Nature communications 2014 Nov 17;5:5496
Nature communications 2014 Nov 17;5:5496
Protective role of RAD50 on chromatin bridges during abnormal cytokinesis.
Schröder-Heurich B, Wieland B, Lavin MF, Schindler D, Dörk T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Mar;28(3):1331-41
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Mar;28(3):1331-41
Functional deficiency of NBN, the Nijmegen breakage syndrome protein, in a p.R215W mutant breast cancer cell line.
Schröder-Heurich B, Bogdanova N, Wieland B, Xie X, Noskowicz M, Park-Simon TW, Hillemanns P, Christiansen H, Dörk T
BMC cancer 2014 Jun 13;14:434
BMC cancer 2014 Jun 13;14:434
Quantitation of DNA double-strand break resection intermediates in human cells.
Zhou Y, Caron P, Legube G, Paull TT
Nucleic acids research 2014 Feb;42(3):e19
Nucleic acids research 2014 Feb;42(3):e19
Distinct functions of human cohesin-SA1 and cohesin-SA2 in double-strand break repair.
Kong X, Ball AR Jr, Pham HX, Zeng W, Chen HY, Schmiesing JA, Kim JS, Berns M, Yokomori K
Molecular and cellular biology 2014 Feb;34(4):685-98
Molecular and cellular biology 2014 Feb;34(4):685-98
Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1.
O'Sullivan RJ, Arnoult N, Lackner DH, Oganesian L, Haggblom C, Corpet A, Almouzni G, Karlseder J
Nature structural & molecular biology 2014 Feb;21(2):167-74
Nature structural & molecular biology 2014 Feb;21(2):167-74
Two sequential cleavage reactions on cruciform DNA structures cause palindrome-mediated chromosomal translocations.
Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, Emanuel BS, Kurahashi H
Nature communications 2013;4:1592
Nature communications 2013;4:1592
Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.
Lee JH, Mand MR, Deshpande RA, Kinoshita E, Yang SH, Wyman C, Paull TT
The Journal of biological chemistry 2013 May 3;288(18):12840-51
The Journal of biological chemistry 2013 May 3;288(18):12840-51
A patient-derived olfactory stem cell disease model for ataxia-telangiectasia.
Stewart R, Kozlov S, Matigian N, Wali G, Gatei M, Sutharsan R, Bellette B, Wraith-Kijas A, Cochrane J, Coulthard M, Perry C, Sinclair K, Mackay-Sim A, Lavin MF
Human molecular genetics 2013 Jun 15;22(12):2495-509
Human molecular genetics 2013 Jun 15;22(12):2495-509
Host DNA damage response facilitates African swine fever virus infection.
Simões M, Martins C, Ferreira F
Veterinary microbiology 2013 Jul 26;165(1-2):140-7
Veterinary microbiology 2013 Jul 26;165(1-2):140-7
Adenovirus regulates sumoylation of Mre11-Rad50-Nbs1 components through a paralog-specific mechanism.
Sohn SY, Hearing P
Journal of virology 2012 Sep;86(18):9656-65
Journal of virology 2012 Sep;86(18):9656-65
A requirement for polymerized actin in DNA double-strand break repair.
Andrin C, McDonald D, Attwood KM, Rodrigue A, Ghosh S, Mirzayans R, Masson JY, Dellaire G, Hendzel MJ
Nucleus (Austin, Tex.) 2012 Jul 1;3(4):384-95
Nucleus (Austin, Tex.) 2012 Jul 1;3(4):384-95
Discordance between phosphorylation and recruitment of 53BP1 in response to DNA double-strand breaks.
Harding SM, Bristow RG
Cell cycle (Georgetown, Tex.) 2012 Apr 1;11(7):1432-44
Cell cycle (Georgetown, Tex.) 2012 Apr 1;11(7):1432-44
Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions.
Tomimatsu N, Mukherjee B, Deland K, Kurimasa A, Bolderson E, Khanna KK, Burma S
DNA repair 2012 Apr 1;11(4):441-8
DNA repair 2012 Apr 1;11(4):441-8
ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.
Gatei M, Jakob B, Chen P, Kijas AW, Becherel OJ, Gueven N, Birrell G, Lee JH, Paull TT, Lerenthal Y, Fazry S, Taucher-Scholz G, Kalb R, Schindler D, Waltes R, Dörk T, Lavin MF
The Journal of biological chemistry 2011 Sep 9;286(36):31542-56
The Journal of biological chemistry 2011 Sep 9;286(36):31542-56
Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway.
Della-Maria J, Zhou Y, Tsai MS, Kuhnlein J, Carney JP, Paull TT, Tomkinson AE
The Journal of biological chemistry 2011 Sep 30;286(39):33845-53
The Journal of biological chemistry 2011 Sep 30;286(39):33845-53
NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis.
Yanagihara H, Kobayashi J, Tateishi S, Kato A, Matsuura S, Tauchi H, Yamada K, Takezawa J, Sugasawa K, Masutani C, Hanaoka F, Weemaes CM, Mori T, Zou L, Komatsu K
Molecular cell 2011 Sep 2;43(5):788-97
Molecular cell 2011 Sep 2;43(5):788-97
Novel regulatory role for Kaposi's sarcoma-associated herpesvirus-encoded vFLIP in chemosensitization to bleomycin.
Masuda Y, Noguchi K, Segawa H, Tanaka N, Katayama K, Mitsuhashi J, Sugimoto Y
Biochemical and biophysical research communications 2011 Nov 18;415(2):305-12
Biochemical and biophysical research communications 2011 Nov 18;415(2):305-12
Adenovirus core protein VII protects the viral genome from a DNA damage response at early times after infection.
Karen KA, Hearing P
Journal of virology 2011 May;85(9):4135-42
Journal of virology 2011 May;85(9):4135-42
Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection.
Forrester NA, Sedgwick GG, Thomas A, Blackford AN, Speiseder T, Dobner T, Byrd PJ, Stewart GS, Turnell AS, Grand RJ
Journal of virology 2011 Mar;85(5):2201-11
Journal of virology 2011 Mar;85(5):2201-11
Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly.
Matsumoto Y, Miyamoto T, Sakamoto H, Izumi H, Nakazawa Y, Ogi T, Tahara H, Oku S, Hiramoto A, Shiiki T, Fujisawa Y, Ohashi H, Sakemi Y, Matsuura S
DNA repair 2011 Mar 7;10(3):314-21
DNA repair 2011 Mar 7;10(3):314-21
Autophosphorylation and ATM activation: additional sites add to the complexity.
Kozlov SV, Graham ME, Jakob B, Tobias F, Kijas AW, Tanuji M, Chen P, Robinson PJ, Taucher-Scholz G, Suzuki K, So S, Chen D, Lavin MF
The Journal of biological chemistry 2011 Mar 18;286(11):9107-19
The Journal of biological chemistry 2011 Mar 18;286(11):9107-19
Human T-lymphotropic type 1 virus p30 inhibits homologous recombination and favors unfaithful DNA repair.
Baydoun HH, Pancewicz J, Nicot C
Blood 2011 Jun 2;117(22):5897-906
Blood 2011 Jun 2;117(22):5897-906
Bocavirus infection induces a DNA damage response that facilitates viral DNA replication and mediates cell death.
Luo Y, Chen AY, Qiu J
Journal of virology 2011 Jan;85(1):133-45
Journal of virology 2011 Jan;85(1):133-45
CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors.
Anderson VE, Walton MI, Eve PD, Boxall KJ, Antoni L, Caldwell JJ, Aherne W, Pearl LH, Oliver AW, Collins I, Garrett MD
Cancer research 2011 Jan 15;71(2):463-72
Cancer research 2011 Jan 15;71(2):463-72
The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection.
Orazio NI, Naeger CM, Karlseder J, Weitzman MD
Journal of virology 2011 Feb;85(4):1887-92
Journal of virology 2011 Feb;85(4):1887-92
Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication.
Adeyemi RO, Landry S, Davis ME, Weitzman MD, Pintel DJ
PLoS pathogens 2010 Oct 7;6(10):e1001141
PLoS pathogens 2010 Oct 7;6(10):e1001141
Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response.
Cha H, Lowe JM, Li H, Lee JS, Belova GI, Bulavin DV, Fornace AJ Jr
Cancer research 2010 May 15;70(10):4112-22
Cancer research 2010 May 15;70(10):4112-22
Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex.
Chailleux C, Tyteca S, Papin C, Boudsocq F, Puget N, Courilleau C, Grigoriev M, Canitrot Y, Trouche D
The Biochemical journal 2010 Feb 24;426(3):365-71
The Biochemical journal 2010 Feb 24;426(3):365-71
Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex.
Balasubramanian N, Bai P, Buchek G, Korza G, Weller SK
Journal of virology 2010 Dec;84(24):12504-14
Journal of virology 2010 Dec;84(24):12504-14
ATM activation in the presence of oxidative stress.
Guo Z, Deshpande R, Paull TT
Cell cycle (Georgetown, Tex.) 2010 Dec 15;9(24):4805-11
Cell cycle (Georgetown, Tex.) 2010 Dec 15;9(24):4805-11
ATM activation in the presence of oxidative stress.
Guo Z, Deshpande R, Paull TT
Cell cycle (Georgetown, Tex.) 2010 Dec 15;9(24):4805-11
Cell cycle (Georgetown, Tex.) 2010 Dec 15;9(24):4805-11
Unique DNA repair gene variations and potential associations with the primary antibody deficiency syndromes IgAD and CVID.
Offer SM, Pan-Hammarström Q, Hammarström L, Harris RS
PloS one 2010 Aug 18;5(8):e12260
PloS one 2010 Aug 18;5(8):e12260
Adeno-associated virus and adenovirus coinfection induces a cellular DNA damage and repair response via redundant phosphatidylinositol 3-like kinase pathways.
Collaco RF, Bevington JM, Bhrigu V, Kalman-Maltese V, Trempe JP
Virology 2009 Sep 15;392(1):24-33
Virology 2009 Sep 15;392(1):24-33
Suppressing the high-level expression and function of ATM in advanced-stage melanomas does not sensitize the cells to ionizing radiation.
Moschos SJ, Dodd NR, Jukic DM, Fayewicz SL, Wang X, Becker D
Cancer biology & therapy 2009 Oct;8(19):1815-25
Cancer biology & therapy 2009 Oct;8(19):1815-25
Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation.
Moody CA, Laimins LA
PLoS pathogens 2009 Oct;5(10):e1000605
PLoS pathogens 2009 Oct;5(10):e1000605
High resolution imaging of changes in the structure and spatial organization of chromatin, gamma-H2A.X and the MRN complex within etoposide-induced DNA repair foci.
Dellaire G, Kepkay R, Bazett-Jones DP
Cell cycle (Georgetown, Tex.) 2009 Nov 15;8(22):3750-69
Cell cycle (Georgetown, Tex.) 2009 Nov 15;8(22):3750-69
Clinical variability and expression of the NBN c.657del5 allele in Nijmegen Breakage Syndrome.
Lins S, Kim R, Krüger L, Chrzanowska KH, Seemanova E, Digweed M
Gene 2009 Nov 1;447(1):12-7
Gene 2009 Nov 1;447(1):12-7
Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.
Waltes R, Kalb R, Gatei M, Kijas AW, Stumm M, Sobeck A, Wieland B, Varon R, Lerenthal Y, Lavin MF, Schindler D, Dörk T
American journal of human genetics 2009 May;84(5):605-16
American journal of human genetics 2009 May;84(5):605-16
Temporal regulation of the Mre11-Rad50-Nbs1 complex during adenovirus infection.
Karen KA, Hoey PJ, Young CS, Hearing P
Journal of virology 2009 May;83(9):4565-73
Journal of virology 2009 May;83(9):4565-73
MRE11 complex links RECQ5 helicase to sites of DNA damage.
Zheng L, Kanagaraj R, Mihaljevic B, Schwendener S, Sartori AA, Gerrits B, Shevelev I, Janscak P
Nucleic acids research 2009 May;37(8):2645-57
Nucleic acids research 2009 May;37(8):2645-57
Altered states of telomere deprotection and the two-stage mechanism of replicative aging.
Zou Y, Misri S, Shay JW, Pandita TK, Wright WE
Molecular and cellular biology 2009 May;29(9):2390-7
Molecular and cellular biology 2009 May;29(9):2390-7
Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection.
Carson CT, Orazio NI, Lee DV, Suh J, Bekker-Jensen S, Araujo FD, Lakdawala SS, Lilley CE, Bartek J, Lukas J, Weitzman MD
The EMBO journal 2009 Mar 18;28(6):652-62
The EMBO journal 2009 Mar 18;28(6):652-62
Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase.
Schwartz RA, Carson CT, Schuberth C, Weitzman MD
Journal of virology 2009 Jun;83(12):6269-78
Journal of virology 2009 Jun;83(12):6269-78
DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression.
Carlessi L, De Filippis L, Lecis D, Vescovi A, Delia D
Cell death and differentiation 2009 Jun;16(6):795-806
Cell death and differentiation 2009 Jun;16(6):795-806
The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses.
Turaga RV, Paquet ER, Sild M, Vignard J, Garand C, Johnson FB, Masson JY, Lebel M
Cell cycle (Georgetown, Tex.) 2009 Jul 1;8(13):2080-92
Cell cycle (Georgetown, Tex.) 2009 Jul 1;8(13):2080-92
MicroRNA regulation of DNA repair gene expression in hypoxic stress.
Crosby ME, Kulshreshtha R, Ivan M, Glazer PM
Cancer research 2009 Feb 1;69(3):1221-9
Cancer research 2009 Feb 1;69(3):1221-9
MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair.
Roques C, Coulombe Y, Delannoy M, Vignard J, Grossi S, Brodeur I, Rodrigue A, Gautier J, Stasiak AZ, Stasiak A, Constantinou A, Masson JY
The EMBO journal 2009 Aug 19;28(16):2400-13
The EMBO journal 2009 Aug 19;28(16):2400-13
DNA ligase I and Nbs1 proteins associate in a complex and colocalize at replication factories.
Vago R, Leva V, Biamonti G, Montecucco A
Cell cycle (Georgetown, Tex.) 2009 Aug 15;8(16):2600-7
Cell cycle (Georgetown, Tex.) 2009 Aug 15;8(16):2600-7
Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation.
Lakdawala SS, Schwartz RA, Ferenchak K, Carson CT, McSharry BP, Wilkinson GW, Weitzman MD
Journal of virology 2008 Sep;82(17):8362-72
Journal of virology 2008 Sep;82(17):8362-72
A glycine-arginine domain in control of the human MRE11 DNA repair protein.
Déry U, Coulombe Y, Rodrigue A, Stasiak A, Richard S, Masson JY
Molecular and cellular biology 2008 May;28(9):3058-69
Molecular and cellular biology 2008 May;28(9):3058-69
Characterization of mre11 loss following HSV-1 infection.
Gregory DA, Bachenheimer SL
Virology 2008 Mar 30;373(1):124-36
Virology 2008 Mar 30;373(1):124-36
DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B.
Palii SS, Van Emburgh BO, Sankpal UT, Brown KD, Robertson KD
Molecular and cellular biology 2008 Jan;28(2):752-71
Molecular and cellular biology 2008 Jan;28(2):752-71
PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites.
Haince JF, McDonald D, Rodrigue A, Déry U, Masson JY, Hendzel MJ, Poirier GG
The Journal of biological chemistry 2008 Jan 11;283(2):1197-208
The Journal of biological chemistry 2008 Jan 11;283(2):1197-208
Processing of recombinant AAV genomes occurs in specific nuclear structures that overlap with foci of DNA-damage-response proteins.
Cervelli T, Palacios JA, Zentilin L, Mano M, Schwartz RA, Weitzman MD, Giacca M
Journal of cell science 2008 Feb 1;121(Pt 3):349-57
Journal of cell science 2008 Feb 1;121(Pt 3):349-57
Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells.
Murakawa Y, Sonoda E, Barber LJ, Zeng W, Yokomori K, Kimura H, Niimi A, Lehmann A, Zhao GY, Hochegger H, Boulton SJ, Takeda S
Cancer research 2007 Sep 15;67(18):8536-43
Cancer research 2007 Sep 15;67(18):8536-43
The effects of 41 degrees C hyperthermia on the DNA repair protein, MRE11, correlate with radiosensitization in four human tumor cell lines.
Xu M, Myerson RJ, Xia Y, Whitehead T, Moros EG, Straube WL, Roti JL
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2007 Jun;23(4):343-51
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2007 Jun;23(4):343-51
Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes.
Fleisig HB, Orazio NI, Liang H, Tyler AF, Adams HP, Weitzman MD, Nagarajan L
Oncogene 2007 Jul 19;26(33):4797-805
Oncogene 2007 Jul 19;26(33):4797-805
Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone.
Bentle MS, Reinicke KE, Dong Y, Bey EA, Boothman DA
Cancer research 2007 Jul 15;67(14):6936-45
Cancer research 2007 Jul 15;67(14):6936-45
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.
Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K
The Journal of biological chemistry 2007 Jul 13;282(28):20395-406
The Journal of biological chemistry 2007 Jul 13;282(28):20395-406
Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export.
Woo JL, Berk AJ
Journal of virology 2007 Jan;81(2):575-87
Journal of virology 2007 Jan;81(2):575-87
Cancer incidence in Nijmegen breakage syndrome is modulated by the amount of a variant NBS protein.
Krüger L, Demuth I, Neitzel H, Varon R, Sperling K, Chrzanowska KH, Seemanova E, Digweed M
Carcinogenesis 2007 Jan;28(1):107-11
Carcinogenesis 2007 Jan;28(1):107-11
The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication.
Schwartz RA, Palacios JA, Cassell GD, Adam S, Giacca M, Weitzman MD
Journal of virology 2007 Dec;81(23):12936-45
Journal of virology 2007 Dec;81(23):12936-45
Mre11 expression in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
Nakanishi K, Kumaki F, Hiroi S, Mukai M, Ikeda E, Kawai T
Archives of pathology & laboratory medicine 2006 Sep;130(9):1330-4
Archives of pathology & laboratory medicine 2006 Sep;130(9):1330-4
Inhibition of hsp90 compromises the DNA damage response to radiation.
Dote H, Burgan WE, Camphausen K, Tofilon PJ
Cancer research 2006 Sep 15;66(18):9211-20
Cancer research 2006 Sep 15;66(18):9211-20
FLASH is required for histone transcription and S-phase progression.
Barcaroli D, Bongiorno-Borbone L, Terrinoni A, Hofmann TG, Rossi M, Knight RA, Matera AG, Melino G, De Laurenzi V
Proceedings of the National Academy of Sciences of the United States of America 2006 Oct 3;103(40):14808-12
Proceedings of the National Academy of Sciences of the United States of America 2006 Oct 3;103(40):14808-12
FLASH is an essential component of Cajal bodies.
Barcaroli D, Dinsdale D, Neale MH, Bongiorno-Borbone L, Ranalli M, Munarriz E, Sayan AE, McWilliam JM, Smith TM, Fava E, Knight RA, Melino G, De Laurenzi V
Proceedings of the National Academy of Sciences of the United States of America 2006 Oct 3;103(40):14802-7
Proceedings of the National Academy of Sciences of the United States of America 2006 Oct 3;103(40):14802-7
Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y
The Journal of biological chemistry 2006 Oct 13;281(41):30814-23
The Journal of biological chemistry 2006 Oct 13;281(41):30814-23
DDB1 maintains genome integrity through regulation of Cdt1.
Lovejoy CA, Lock K, Yenamandra A, Cortez D
Molecular and cellular biology 2006 Nov;26(21):7977-90
Molecular and cellular biology 2006 Nov;26(21):7977-90
Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype.
Gueven N, Becherel OJ, Birrell G, Chen P, DelSal G, Carney JP, Grattan-Smith P, Lavin MF
Cancer research 2006 Mar 15;66(6):2907-12
Cancer research 2006 Mar 15;66(6):2907-12
Mild Nijmegen breakage syndrome phenotype due to alternative splicing.
Varon R, Dutrannoy V, Weikert G, Tanzarella C, Antoccia A, Stöckl L, Spadoni E, Krüger LA, di Masi A, Sperling K, Digweed M, Maraschio P
Human molecular genetics 2006 Mar 1;15(5):679-89
Human molecular genetics 2006 Mar 1;15(5):679-89
The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres.
Chai W, Sfeir AJ, Hoshiyama H, Shay JW, Wright WE
EMBO reports 2006 Feb;7(2):225-30
EMBO reports 2006 Feb;7(2):225-30
Involvement of novel autophosphorylation sites in ATM activation.
Kozlov SV, Graham ME, Peng C, Chen P, Robinson PJ, Lavin MF
The EMBO journal 2006 Aug 9;25(15):3504-14
The EMBO journal 2006 Aug 9;25(15):3504-14
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks.
Bekker-Jensen S, Lukas C, Kitagawa R, Melander F, Kastan MB, Bartek J, Lukas J
The Journal of cell biology 2006 Apr 24;173(2):195-206
The Journal of cell biology 2006 Apr 24;173(2):195-206
hMRE11 deficiency leads to microsatellite instability and defective DNA mismatch repair.
Vo AT, Zhu F, Wu X, Yuan F, Gao Y, Gu L, Li GM, Lee TH, Her C
EMBO reports 2005 May;6(5):438-44
EMBO reports 2005 May;6(5):438-44
Analysis of ionizing radiation-induced foci of DNA damage repair proteins.
van Veelen LR, Cervelli T, van de Rakt MW, Theil AF, Essers J, Kanaar R
Mutation research 2005 Jul 1;574(1-2):22-33
Mutation research 2005 Jul 1;574(1-2):22-33
The adenovirus E4orf6 protein inhibits DNA double strand break repair and radiosensitizes human tumor cells in an E1B-55K-independent manner.
Hart LS, Yannone SM, Naczki C, Orlando JS, Waters SB, Akman SA, Chen DJ, Ornelles D, Koumenis C
The Journal of biological chemistry 2005 Jan 14;280(2):1474-81
The Journal of biological chemistry 2005 Jan 14;280(2):1474-81
Evidence for the direct binding of phosphorylated p53 to sites of DNA breaks in vivo.
Al Rashid ST, Dellaire G, Cuddihy A, Jalali F, Vaid M, Coackley C, Folkard M, Xu Y, Chen BP, Chen DJ, Lilge L, Prise KM, Bazett Jones DP, Bristow RG
Cancer research 2005 Dec 1;65(23):10810-21
Cancer research 2005 Dec 1;65(23):10810-21
Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells.
Kim JS, Krasieva TB, Kurumizaka H, Chen DJ, Taylor AM, Yokomori K
The Journal of cell biology 2005 Aug 1;170(3):341-7
The Journal of cell biology 2005 Aug 1;170(3):341-7
DNA repair proteins affect the lifecycle of herpes simplex virus 1.
Lilley CE, Carson CT, Muotri AR, Gage FH, Weitzman MD
Proceedings of the National Academy of Sciences of the United States of America 2005 Apr 19;102(16):5844-9
Proceedings of the National Academy of Sciences of the United States of America 2005 Apr 19;102(16):5844-9
Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.
Zhang X, Succi J, Feng Z, Prithivirajsingh S, Story MD, Legerski RJ
Molecular and cellular biology 2004 Oct;24(20):9207-20
Molecular and cellular biology 2004 Oct;24(20):9207-20
Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage response.
Wilkinson DE, Weller SK
Journal of virology 2004 May;78(9):4783-96
Journal of virology 2004 May;78(9):4783-96
Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression.
Fan R, Kumaravel TS, Jalali F, Marrano P, Squire JA, Bristow RG
Cancer research 2004 Dec 1;64(23):8526-33
Cancer research 2004 Dec 1;64(23):8526-33
BLM and the FANC proteins collaborate in a common pathway in response to stalled replication forks.
Pichierri P, Franchitto A, Rosselli F
The EMBO journal 2004 Aug 4;23(15):3154-63
The EMBO journal 2004 Aug 4;23(15):3154-63
Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forks.
Robison JG, Elliott J, Dixon K, Oakley GG
The Journal of biological chemistry 2004 Aug 13;279(33):34802-10
The Journal of biological chemistry 2004 Aug 13;279(33):34802-10
Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability.
Giannini G, Rinaldi C, Ristori E, Ambrosini MI, Cerignoli F, Viel A, Bidoli E, Berni S, D'Amati G, Scambia G, Frati L, Screpanti I, Gulino A
Oncogene 2004 Apr 8;23(15):2640-7
Oncogene 2004 Apr 8;23(15):2640-7
Slow progression of ataxia-telangiectasia with double missense and in frame splice mutations.
Dörk T, Bendix-Waltes R, Wegner RD, Stumm M
American journal of medical genetics. Part A 2004 Apr 30;126A(3):272-7
American journal of medical genetics. Part A 2004 Apr 30;126A(3):272-7
Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation.
Horejsí Z, Falck J, Bakkenist CJ, Kastan MB, Lukas J, Bartek J
Oncogene 2004 Apr 15;23(17):3122-7
Oncogene 2004 Apr 15;23(17):3122-7
The Mason-Pfizer monkey virus PPPY and PSAP motifs both contribute to virus release.
Gottwein E, Bodem J, Müller B, Schmechel A, Zentgraf H, Kräusslich HG
Journal of virology 2003 Sep;77(17):9474-85
Journal of virology 2003 Sep;77(17):9474-85
NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors.
Xu X, Stern DF
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003 Oct;17(13):1842-8
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003 Oct;17(13):1842-8
Requirement of the MRN complex for ATM activation by DNA damage.
Uziel T, Lerenthal Y, Moyal L, Andegeko Y, Mittelman L, Shiloh Y
The EMBO journal 2003 Oct 15;22(20):5612-21
The EMBO journal 2003 Oct 15;22(20):5612-21
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage.
Lukas C, Falck J, Bartkova J, Bartek J, Lukas J
Nature cell biology 2003 Mar;5(3):255-60
Nature cell biology 2003 Mar;5(3):255-60
NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways.
Xu X, Stern DF
The Journal of biological chemistry 2003 Mar 7;278(10):8795-803
The Journal of biological chemistry 2003 Mar 7;278(10):8795-803
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.
Celeste A, Fernandez-Capetillo O, Kruhlak MJ, Pilch DR, Staudt DW, Lee A, Bonner RF, Bonner WM, Nussenzweig A
Nature cell biology 2003 Jul;5(7):675-9
Nature cell biology 2003 Jul;5(7):675-9
Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.
Lee JH, Xu B, Lee CH, Ahn JY, Song MS, Lee H, Canman CE, Lee JS, Kastan MB, Lim DS
Molecular cancer research : MCR 2003 Jul;1(9):674-81
Molecular cancer research : MCR 2003 Jul;1(9):674-81
MDC1 is a mediator of the mammalian DNA damage checkpoint.
Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ
Nature 2003 Feb 27;421(6926):961-6
Nature 2003 Feb 27;421(6926):961-6
The Mre11 complex is required for ATM activation and the G2/M checkpoint.
Carson CT, Schwartz RA, Stracker TH, Lilley CE, Lee DV, Weitzman MD
The EMBO journal 2003 Dec 15;22(24):6610-20
The EMBO journal 2003 Dec 15;22(24):6610-20
Radiosensitization of heat resistant human tumour cells by 1 hour at 41.1 degrees C and its effect on DNA repair.
Xu M, Myerson RJ, Straube WL, Moros EG, Lagroye I, Wang LL, Lee JT, Roti Roti JL
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2002 Sep-Oct;18(5):385-403
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2002 Sep-Oct;18(5):385-403
Evidence for a direct association of hMRE11 with the human mismatch repair protein hMLH1.
Her C, Vo AT, Wu X
DNA repair 2002 Sep 4;1(9):719-29
DNA repair 2002 Sep 4;1(9):719-29
DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein.
Pichierri P, Averbeck D, Rosselli F
Human molecular genetics 2002 Oct 1;11(21):2531-46
Human molecular genetics 2002 Oct 1;11(21):2531-46
Specific recruitment of human cohesin to laser-induced DNA damage.
Kim JS, Krasieva TB, LaMorte V, Taylor AM, Yokomori K
The Journal of biological chemistry 2002 Nov 22;277(47):45149-53
The Journal of biological chemistry 2002 Nov 22;277(47):45149-53
Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex.
Stracker TH, Carson CT, Weitzman MD
Nature 2002 Jul 18;418(6895):348-52
Nature 2002 Jul 18;418(6895):348-52
UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization.
Limoli CL, Giedzinski E, Bonner WM, Cleaver JE
Proceedings of the National Academy of Sciences of the United States of America 2002 Jan 8;99(1):233-8
Proceedings of the National Academy of Sciences of the United States of America 2002 Jan 8;99(1):233-8
Interaction of FANCD2 and NBS1 in the DNA damage response.
Nakanishi K, Taniguchi T, Ranganathan V, New HV, Moreau LA, Stotsky M, Mathew CG, Kastan MB, Weaver DT, D'Andrea AD
Nature cell biology 2002 Dec;4(12):913-20
Nature cell biology 2002 Dec;4(12):913-20
hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage.
Richie CT, Peterson C, Lu T, Hittelman WN, Carpenter PB, Legerski RJ
Molecular and cellular biology 2002 Dec;22(24):8635-47
Molecular and cellular biology 2002 Dec;22(24):8635-47
Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome.
Harfst E, Cooper S, Neubauer S, Distel L, Grawunder U
Molecular immunology 2000 Oct;37(15):915-29
Molecular immunology 2000 Oct;37(15):915-29
ATM-dependent phosphorylation of nibrin in response to radiation exposure.
Gatei M, Young D, Cerosaletti KM, Desai-Mehta A, Spring K, Kozlov S, Lavin MF, Gatti RA, Concannon P, Khanna K
Nature genetics 2000 May;25(1):115-9
Nature genetics 2000 May;25(1):115-9
Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres.
Lombard DB, Guarente L
Cancer research 2000 May 1;60(9):2331-4
Cancer research 2000 May 1;60(9):2331-4
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J
Genes & development 2000 Apr 15;14(8):927-39
Genes & development 2000 Apr 15;14(8):927-39
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- Non-transfected (¡V) and transfected (+) HeLa whole cell extracts (30 ?g) were separated by 7.5% SDS-PAGE, and the membrane was blotted with Mre11 antibody [12D7] (GTX70212) diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
Supportive validation
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- GeneTex (provider)
- Main image
- Experimental details
- Analysis of human MRE11 expression by western blot in HeLa (1) and Raji (2) whole cell extracts using anti-MRE11 [12D7] monoclonal antibody (GTX70212). The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
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- GeneTex (provider)
- Main image
- Experimental details
- Mre11 antibody [12D7] detects Mre11 protein by western blot analysis.A. 30 ?g Jurkat whole cell extract B. 30 ?g Raji whole cell extract C. 30 ?g NCI-H929 whole cell extract7.5% SDS-PAGEMre11 antibody [12D7] (GTX70212) dilution: 1:1000The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
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- GeneTex (provider)
- Main image
- Experimental details
- Mre11 antibody [12D7] detects Mre11 protein by western blot analysis.A. 30 ?g 293T whole cell extract B. 30 ?g whole cell extract of human Mre11-transfected 293T cells7.5% SDS-PAGEMre11 antibody [12D7] (GTX70212) dilution: 1:1000The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Mre11 antibody [12D7] detects Mre11 protein by western blot analysis.A. 30 ?g HeLa whole cell extract7.5 % SDS-PAGEMre11 antibody [12D7] (GTX70212) dilution: 1:1000
- Validation comment
- WB
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Whole cell extract (30 ?g) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Mre11 antibody [12D7] (GTX70212) diluted at 1:1000.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Whole cell extract (30 ?g) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Mre11 antibody [12D7] (GTX70212) diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Non-transfected (¡V) and transfected (+) HeLa whole cell extracts (30 ?g) were separated by 7.5% SDS-PAGE, and the membrane was blotted with Mre11 antibody [12D7] (GTX70212) diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
