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Protein structure
MRE11
MRE11 homolog, double strand break repair nucleaseATLD, MRE11A
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| GeneTex |  GTX70212 |
137 references | Monoclonal |
WB
EL
ICC
IP
IHC
FA
PLA
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| Novus Biologicals | NB100-142 |
181 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC
ChIP
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| antibodies-online | ABIN151076 |
150 references | Polyclonal |
WB
ICC
IP
IHC
FC
ChIP
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| Proteintech Group | 10744-1-AP |
9 references | Polyclonal |
WB
EL
IP
IHC
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| LSBio | LS-C352549 |
Polyclonal |
WB
ICC
IP
IHC
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