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- References [20]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 10744-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10744-1-AP, RRID:AB_2145118
- Product name
- MRE11 antibody
- Antibody type
- Polyclonal
- Description
- MRE11 antibody (Cat. #10744-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references HAT1 functions as a lactyltransferase and mediates RPA1 lactylation to promote DNA repair and radioresistance in lung adenocarcinoma.
CNOT7 facilitates radiation resistance in colorectal cancer through TRIM21/XRCC6-mediated non-homologous end joining repair.
Adolescent cetylpyridinium chloride exposure impairs homologous recombination repair and induces granulosa cell apoptosis and follicular atresia via FOXM1/CREBBP complex suppression.
Senataxin and DNA-PKcs redundantly promote non-homologous end joining repair of DNA double strand breaks during V(D)J recombination.
Alpha-synuclein mutations mislocalize cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition.
Gonadal sex and temperature independently influence germ cell differentiation and meiotic progression in Trachemys scripta.
MRE11-independent effects of Mirin on mitochondrial DNA integrity and cellular immune responses.
LncRNA FTX promotes colorectal cancer radioresistance through disturbing redox balance and inhibiting ferroptosis via miR-625-5p/SCL7A11 axis.
Senataxin and DNA-PKcs Redundantly Promote Non-Homologous End Joining Repair of DNA Double Strand Breaks During V(D)J Recombination.
NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors.
MRE11A: a novel negative regulator of human DNA mismatch repair.
Guanosine diphosphate-mannose suppresses homologous recombination repair and potentiates antitumor immunity in triple-negative breast cancer.
UFL1 triggers replication fork degradation by MRE11 in BRCA1/2-deficient cells.
Ibuprofen modulates macrophage polarization by downregulating poly (ADP-ribose) polymerase 1.
TRIM24 is critical for the cellular response to DNA double-strand breaks through regulating the recruitment of MRN complex.
Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin.
Acquired temozolomide resistance in MGMT(low) gliomas is associated with regulation of homologous recombination repair by ROCK2.
A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress.
Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats.
MiR-34s negatively regulate homologous recombination through targeting RAD51.
He J, Lai T, Zhao Y, Zhou Z, Zhou L, Tao D, Yang H, Li N, He Y, Yang S, Tang Z, Zeng S, Munai E, Liu Y, Tan Y, Zhou W, Wu Y
Cell death & disease 2025 Nov 21;16(1):851
Cell death & disease 2025 Nov 21;16(1):851
CNOT7 facilitates radiation resistance in colorectal cancer through TRIM21/XRCC6-mediated non-homologous end joining repair.
Li Y, Cui L, Wang S, Zhao Q, Du F, Du S, Yu C, Xia M, Zhao S, Luan T, Liu Y, Cui B
Cell death & disease 2025 Nov 17;16(1):833
Cell death & disease 2025 Nov 17;16(1):833
Adolescent cetylpyridinium chloride exposure impairs homologous recombination repair and induces granulosa cell apoptosis and follicular atresia via FOXM1/CREBBP complex suppression.
Ma L, Yin X, Zhang Y, Ma Y, Geng Y, Mu X, Gao R, Chen X, He J
Ecotoxicology and environmental safety 2025 May;296:118193
Ecotoxicology and environmental safety 2025 May;296:118193
Senataxin and DNA-PKcs redundantly promote non-homologous end joining repair of DNA double strand breaks during V(D)J recombination.
Chen BR, Pham T, Reynolds LD, Dang N, Zhang Y, Manalang K, Matos-Rodrigues G, Neidigk JR, Nussenzweig A, Tyler JK, Sleckman BP
Science advances 2025 Jun 20;11(25):eads5272
Science advances 2025 Jun 20;11(25):eads5272
Alpha-synuclein mutations mislocalize cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition.
Son SM, Siddiqi FH, Lopez A, Ansari R, Tyrkalska SD, Park SJ, Kunath T, Metzakopian E, Fleming A, Rubinsztein DC
Neuron 2025 Jun 18;113(12):1908-1924.e13
Neuron 2025 Jun 18;113(12):1908-1924.e13
Gonadal sex and temperature independently influence germ cell differentiation and meiotic progression in Trachemys scripta.
Hatkevich T, Tezak BM, Acemel RD, Yee Chung VW, Lupiáñez DG, Capel B
Proceedings of the National Academy of Sciences of the United States of America 2025 Jan 7;122(1):e2413191121
Proceedings of the National Academy of Sciences of the United States of America 2025 Jan 7;122(1):e2413191121
MRE11-independent effects of Mirin on mitochondrial DNA integrity and cellular immune responses.
Aasumets K, Hangas A, Fragkoulis G, Bader CPJ, Erdinc D, Wanrooij S, Wanrooij PH, Goffart S, Pohjoismäki JLO
Molecular biology of the cell 2025 Feb 1;36(2):ar11
Molecular biology of the cell 2025 Feb 1;36(2):ar11
LncRNA FTX promotes colorectal cancer radioresistance through disturbing redox balance and inhibiting ferroptosis via miR-625-5p/SCL7A11 axis.
Dai Q, Qu TY, Yang JL, Leng J, Fang L, Zhu QQ, Wu KB, Wu J, Ma JJ, Yu HF
World journal of gastroenterology 2025 Apr 28;31(16):104305
World journal of gastroenterology 2025 Apr 28;31(16):104305
Senataxin and DNA-PKcs Redundantly Promote Non-Homologous End Joining Repair of DNA Double Strand Breaks During V(D)J Recombination.
Chen BR, Pham T, Reynolds LD, Dang N, Zhang Y, Manalang K, Matos-Rodrigues G, Neidigk JR, Nussenzweig A, Tyler JK, Sleckman BP
bioRxiv : the preprint server for biology 2024 Sep 26;
bioRxiv : the preprint server for biology 2024 Sep 26;
NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors.
Wang Y, Liu X, Zuo X, Wang C, Zhang Z, Zhang H, Zeng T, Chen S, Liu M, Chen H, Song Q, Li Q, Yang C, Le Y, Xing J, Zhang H, An J, Jia W, Kang L, Zhang H, Xie H, Ye J, Wu T, He F, Zhang X, Li Y, Zhou G
Cell genomics 2024 May 8;4(5):100550
Cell genomics 2024 May 8;4(5):100550
MRE11A: a novel negative regulator of human DNA mismatch repair.
Du D, Yang Y, Zhang Y, Wang G, Chen L, Guan X, Rasmussen LJ, Liu D
Cellular & molecular biology letters 2024 Mar 14;29(1):37
Cellular & molecular biology letters 2024 Mar 14;29(1):37
Guanosine diphosphate-mannose suppresses homologous recombination repair and potentiates antitumor immunity in triple-negative breast cancer.
Ding JH, Xiao Y, Yang F, Song XQ, Xu Y, Ding XH, Ding R, Shao ZM, Di GH, Jiang YZ
Science translational medicine 2024 Jan 3;16(728):eadg7740
Science translational medicine 2024 Jan 3;16(728):eadg7740
UFL1 triggers replication fork degradation by MRE11 in BRCA1/2-deficient cells.
Tian T, Chen J, Zhao H, Li Y, Xia F, Huang J, Han J, Liu T
Nature chemical biology 2024 Dec;20(12):1650-1661
Nature chemical biology 2024 Dec;20(12):1650-1661
Ibuprofen modulates macrophage polarization by downregulating poly (ADP-ribose) polymerase 1.
Wang PH, Wang Y, Guo YY, Ma ZH, Wu C, Xing L
International immunopharmacology 2024 Dec 25;143(Pt 3):113502
International immunopharmacology 2024 Dec 25;143(Pt 3):113502
TRIM24 is critical for the cellular response to DNA double-strand breaks through regulating the recruitment of MRN complex.
Wang Y, Yao Y, Wei Q, Long S, Chen Y, Xie J, Tan R, Jiang W, Zhang Q, Wu D, Xiao S, Wan F, Fu K
Oncogene 2023 Feb;42(8):586-600
Oncogene 2023 Feb;42(8):586-600
Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin.
Zhang T, Yang H, Zhou Z, Bai Y, Wang J, Wang W
Nature communications 2022 Sep 1;13(1):5133
Nature communications 2022 Sep 1;13(1):5133
Acquired temozolomide resistance in MGMT(low) gliomas is associated with regulation of homologous recombination repair by ROCK2.
Zhang X, Li T, Yang M, Du Q, Wang R, Fu B, Tan Y, Cao M, Chen Y, Wang Q, Hu R
Cell death & disease 2022 Feb 10;13(2):138
Cell death & disease 2022 Feb 10;13(2):138
A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress.
Griffin WC, McKinzey DR, Klinzing KN, Baratam R, Eliyapura A, Trakselis MA
Nature communications 2022 Aug 30;13(1):5090
Nature communications 2022 Aug 30;13(1):5090
Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats.
Aiken CE, Tarry-Adkins JL, Spiroski AM, Nuzzo AM, Ashmore TJ, Rolfo A, Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE
The Journal of physiology 2019 May;597(9):2391-2401
The Journal of physiology 2019 May;597(9):2391-2401
MiR-34s negatively regulate homologous recombination through targeting RAD51.
Chen S, Liu R, Wang Q, Qi Z, Hu Y, Zhou P, Wang Z
Archives of biochemistry and biophysics 2019 May 15;666:73-82
Archives of biochemistry and biophysics 2019 May 15;666:73-82
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A431 cells were subjected to SDS PAGE followed by western blot with 10744-1-AP(MRE11A antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MRE11 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MRE11. This antibody recognizes human,mouse,rat antigen. The MRE11 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
