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- Product number
- ABIN151920 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified
- Reactivity
- Human, Mouse
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 12D7
- Vial size
- 100 μL
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906.
MRE11 complex links RECQ5 helicase to sites of DNA damage.
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.
MRE11 expression is impaired in gastric cancer with microsatellite instability.
Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability.
NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors.
Requirement of the MRN complex for ATM activation by DNA damage.
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage.
NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways.
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.
Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.
MDC1 is a mediator of the mammalian DNA damage checkpoint.
Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex.
UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization.
Interaction of FANCD2 and NBS1 in the DNA damage response.
Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome.
ATM-dependent phosphorylation of nibrin in response to radiation exposure.
Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres.
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response.
The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance.
The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.
Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95.
Soares DG, Battistella A, Rocca CJ, Matuo R, Henriques JA, Larsen AK, Escargueil AE
The Biochemical journal 2011 Jul 1;437(1):63-73
The Biochemical journal 2011 Jul 1;437(1):63-73
MRE11 complex links RECQ5 helicase to sites of DNA damage.
Zheng L, Kanagaraj R, Mihaljevic B, Schwendener S, Sartori AA, Gerrits B, Shevelev I, Janscak P
Nucleic acids research 2009 May;37(8):2645-57
Nucleic acids research 2009 May;37(8):2645-57
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.
Helmink BA, Bredemeyer AL, Lee BS, Huang CY, Sharma GG, Walker LM, Bednarski JJ, Lee WL, Pandita TK, Bassing CH, Sleckman BP
The Journal of experimental medicine 2009 Mar 16;206(3):669-79
The Journal of experimental medicine 2009 Mar 16;206(3):669-79
MRE11 expression is impaired in gastric cancer with microsatellite instability.
Ottini L, Falchetti M, Saieva C, De Marco M, Masala G, Zanna I, Paglierani M, Giannini G, Gulino A, Nesi G, Mariani Costantini R, Palli D
Carcinogenesis 2004 Dec;25(12):2337-43
Carcinogenesis 2004 Dec;25(12):2337-43
Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability.
Giannini G, Rinaldi C, Ristori E, Ambrosini MI, Cerignoli F, Viel A, Bidoli E, Berni S, D'Amati G, Scambia G, Frati L, Screpanti I, Gulino A
Oncogene 2004 Apr 8;23(15):2640-7
Oncogene 2004 Apr 8;23(15):2640-7
NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors.
Xu X, Stern DF
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003 Oct;17(13):1842-8
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003 Oct;17(13):1842-8
Requirement of the MRN complex for ATM activation by DNA damage.
Uziel T, Lerenthal Y, Moyal L, Andegeko Y, Mittelman L, Shiloh Y
The EMBO journal 2003 Oct 15;22(20):5612-21
The EMBO journal 2003 Oct 15;22(20):5612-21
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage.
Lukas C, Falck J, Bartkova J, Bartek J, Lukas J
Nature cell biology 2003 Mar;5(3):255-60
Nature cell biology 2003 Mar;5(3):255-60
NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways.
Xu X, Stern DF
The Journal of biological chemistry 2003 Mar 7;278(10):8795-803
The Journal of biological chemistry 2003 Mar 7;278(10):8795-803
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.
Celeste A, Fernandez-Capetillo O, Kruhlak MJ, Pilch DR, Staudt DW, Lee A, Bonner RF, Bonner WM, Nussenzweig A
Nature cell biology 2003 Jul;5(7):675-9
Nature cell biology 2003 Jul;5(7):675-9
Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.
Lee JH, Xu B, Lee CH, Ahn JY, Song MS, Lee H, Canman CE, Lee JS, Kastan MB, Lim DS
Molecular cancer research : MCR 2003 Jul;1(9):674-81
Molecular cancer research : MCR 2003 Jul;1(9):674-81
MDC1 is a mediator of the mammalian DNA damage checkpoint.
Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ
Nature 2003 Feb 27;421(6926):961-6
Nature 2003 Feb 27;421(6926):961-6
Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex.
Stracker TH, Carson CT, Weitzman MD
Nature 2002 Jul 18;418(6895):348-52
Nature 2002 Jul 18;418(6895):348-52
UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization.
Limoli CL, Giedzinski E, Bonner WM, Cleaver JE
Proceedings of the National Academy of Sciences of the United States of America 2002 Jan 8;99(1):233-8
Proceedings of the National Academy of Sciences of the United States of America 2002 Jan 8;99(1):233-8
Interaction of FANCD2 and NBS1 in the DNA damage response.
Nakanishi K, Taniguchi T, Ranganathan V, New HV, Moreau LA, Stotsky M, Mathew CG, Kastan MB, Weaver DT, D'Andrea AD
Nature cell biology 2002 Dec;4(12):913-20
Nature cell biology 2002 Dec;4(12):913-20
Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome.
Harfst E, Cooper S, Neubauer S, Distel L, Grawunder U
Molecular immunology 2000 Oct;37(15):915-29
Molecular immunology 2000 Oct;37(15):915-29
ATM-dependent phosphorylation of nibrin in response to radiation exposure.
Gatei M, Young D, Cerosaletti KM, Desai-Mehta A, Spring K, Kozlov S, Lavin MF, Gatti RA, Concannon P, Khanna K
Nature genetics 2000 May;25(1):115-9
Nature genetics 2000 May;25(1):115-9
Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres.
Lombard DB, Guarente L
Cancer research 2000 May 1;60(9):2331-4
Cancer research 2000 May 1;60(9):2331-4
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J
Genes & development 2000 Apr 15;14(8):927-39
Genes & development 2000 Apr 15;14(8):927-39
Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response.
Zhong Q, Chen CF, Li S, Chen Y, Wang CC, Xiao J, Chen PL, Sharp ZD, Lee WH
Science (New York, N.Y.) 1999 Jul 30;285(5428):747-50
Science (New York, N.Y.) 1999 Jul 30;285(5428):747-50
The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance.
Moreau S, Ferguson JR, Symington LS
Molecular and cellular biology 1999 Jan;19(1):556-66
Molecular and cellular biology 1999 Jan;19(1):556-66
The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.
Carney JP, Maser RS, Olivares H, Davis EM, Le Beau M, Yates JR 3rd, Hays L, Morgan WF, Petrini JH
Cell 1998 May 1;93(3):477-86
Cell 1998 May 1;93(3):477-86
Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95.
Trujillo KM, Yuan SS, Lee EY, Sung P
The Journal of biological chemistry 1998 Aug 21;273(34):21447-50
The Journal of biological chemistry 1998 Aug 21;273(34):21447-50
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